CR2Cancer

Summary
Symbol	ATF2
Name	activating transcription factor 2
Aliases	TREB7; CRE-BP1; HB16; cAMP responsive element binding protein 2; activating transcription factor 2 splice va ......
Location	2q31.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Domain, Function and Classification > Gene Ontology > KEGG and Reactome Pathway

> Domain, Function and Classification

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Domain

PF00170 bZIP transcription factor

Function

Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA-3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA-3'). In the nucleus, contributes to global transcription and the DNA damage response, in addition to specific transcriptional activities that are related to cell development, proliferation and death. In the cytoplasm, interacts with and perturbs HK1- and VDAC1-containing complexes at the mitochondrial outer membrane, thereby impairing mitochondrial membrane potential, inducing mitochondrial leakage and promoting cell death. The phosphorylated form (mediated by ATM) plays a role in the DNA damage response and is involved in the ionizing radiation (IR)-induced S phase checkpoint control and in the recruitment of the MRN complex into the IR-induced foci (IRIF). Exhibits histone acetyltransferase (HAT) activity which specifically acetylates histones H2B and H4 in vitro. In concert with CUL3 and RBX1, promotes the degradation of KAT5 thereby attenuating its ability to acetylate and activate ATM. Can elicit oncogenic or tumor suppressor activities depending on the tissue or cell type.

Classification

Class	Modification	Substrate	Product	PubMed
Histone modification write	Histone acetylation	H2B, H4, DNA motif	#	10821277

> Gene Ontology [ TOP ]
Biological Process	GO:0000075 cell cycle checkpoint GO:0000077 DNA damage checkpoint GO:0001101 response to acid chemical GO:0001819 positive regulation of cytokine production GO:0003007 heart morphogenesis GO:0003151 outflow tract morphogenesis GO:0006473 protein acetylation GO:0006475 internal protein amino acid acetylation GO:0006839 mitochondrial transport GO:0006970 response to osmotic stress GO:0007006 mitochondrial membrane organization GO:0007093 mitotic cell cycle checkpoint GO:0007346 regulation of mitotic cell cycle GO:0007507 heart development GO:0008637 apoptotic mitochondrial changes GO:0009414 response to water deprivation GO:0009415 response to water GO:0010035 response to inorganic substance GO:0016570 histone modification GO:0016573 histone acetylation GO:0018205 peptidyl-lysine modification GO:0018393 internal peptidyl-lysine acetylation GO:0018394 peptidyl-lysine acetylation GO:0031570 DNA integrity checkpoint GO:0031573 intra-S DNA damage checkpoint GO:0032906 transforming growth factor beta2 production GO:0032909 regulation of transforming growth factor beta2 production GO:0032915 positive regulation of transforming growth factor beta2 production GO:0035794 positive regulation of mitochondrial membrane permeability GO:0042475 odontogenesis of dentin-containing tooth GO:0042476 odontogenesis GO:0043523 regulation of neuron apoptotic process GO:0043525 positive regulation of neuron apoptotic process GO:0043543 protein acylation GO:0044773 mitotic DNA damage checkpoint GO:0044774 mitotic DNA integrity checkpoint GO:0045444 fat cell differentiation GO:0045786 negative regulation of cell cycle GO:0045930 negative regulation of mitotic cell cycle GO:0046902 regulation of mitochondrial membrane permeability GO:0050673 epithelial cell proliferation GO:0050678 regulation of epithelial cell proliferation GO:0050680 negative regulation of epithelial cell proliferation GO:0051090 regulation of sequence-specific DNA binding transcription factor activity GO:0051091 positive regulation of sequence-specific DNA binding transcription factor activity GO:0051402 neuron apoptotic process GO:0060612 adipose tissue development GO:0061448 connective tissue development GO:0070997 neuron death GO:0071604 transforming growth factor beta production GO:0071634 regulation of transforming growth factor beta production GO:0071636 positive regulation of transforming growth factor beta production GO:0090559 regulation of membrane permeability GO:0097186 amelogenesis GO:1901214 regulation of neuron death GO:1901216 positive regulation of neuron death GO:1902108 regulation of mitochondrial membrane permeability involved in apoptotic process GO:1902110 positive regulation of mitochondrial membrane permeability involved in apoptotic process GO:1902686 mitochondrial outer membrane permeabilization involved in programmed cell death
Molecular Function	GO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding GO:0000982 transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding GO:0001076 transcription factor activity, RNA polymerase II transcription factor binding GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding GO:0001085 RNA polymerase II transcription factor binding GO:0001102 RNA polymerase II activating transcription factor binding GO:0001158 enhancer sequence-specific DNA binding GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding GO:0003682 chromatin binding GO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding GO:0003713 transcription coactivator activity GO:0004402 histone acetyltransferase activity GO:0008080 N-acetyltransferase activity GO:0008134 transcription factor binding GO:0008140 cAMP response element binding protein binding GO:0016407 acetyltransferase activity GO:0016410 N-acyltransferase activity GO:0016746 transferase activity, transferring acyl groups GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups GO:0033613 activating transcription factor binding GO:0034212 peptide N-acetyltransferase activity GO:0035326 enhancer binding GO:0035497 cAMP response element binding GO:0046982 protein heterodimerization activity GO:0061733 peptide-lysine-N-acetyltransferase activity
Cellular Component	GO:0005741 mitochondrial outer membrane GO:0019867 outer membrane GO:0031968 organelle outer membrane GO:0035861 site of double-strand break

> KEGG and Reactome Pathway [ TOP ]
KEGG	hsa04010 MAPK signaling pathway hsa04022 cGMP-PKG signaling pathway hsa04151 PI3K-Akt signaling pathway hsa04261 Adrenergic signaling in cardiomyocytes hsa04668 TNF signaling pathway hsa04728 Dopaminergic synapse hsa04911 Insulin secretion hsa04915 Estrogen signaling pathway hsa04918 Thyroid hormone synthesis hsa04922 Glucagon signaling pathway
Reactome	R-HSA-166054: Activated TLR4 signalling R-HSA-450341: Activation of the AP-1 family of transcription factors R-HSA-3247509: Chromatin modifying enzymes R-HSA-4839726: Chromatin organization R-HSA-400253: Circadian Clock R-HSA-74160: Gene Expression R-HSA-212436: Generic Transcription Pathway R-HSA-3214847: HATs acetylate histones R-HSA-168256: Immune System R-HSA-168249: Innate Immune System R-HSA-450294: MAP kinase activation in TLR cascade R-HSA-450282: MAPK targets/ Nuclear events mediated by MAP kinases R-HSA-1592230: Mitochondrial biogenesis R-HSA-975871: MyD88 cascade initiated on plasma membrane R-HSA-975155: MyD88 dependent cascade initiated on endosome R-HSA-166166: MyD88-independent TLR3/TLR4 cascade R-HSA-166058: MyD88 R-HSA-1852241: Organelle biogenesis and maintenance R-HSA-6796648: TP53 Regulates Transcription of DNA Repair Genes R-HSA-168180: TRAF6 Mediated Induction of proinflammatory cytokines R-HSA-975138: TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-937061: TRIF-mediated TLR3/TLR4 signaling R-HSA-168142: Toll Like Receptor 10 (TLR10) Cascade R-HSA-181438: Toll Like Receptor 2 (TLR2) Cascade R-HSA-168164: Toll Like Receptor 3 (TLR3) Cascade R-HSA-166016: Toll Like Receptor 4 (TLR4) Cascade R-HSA-168176: Toll Like Receptor 5 (TLR5) Cascade R-HSA-168181: Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168138: Toll Like Receptor 9 (TLR9) Cascade R-HSA-168179: Toll Like Receptor TLR1 R-HSA-168188: Toll Like Receptor TLR6 R-HSA-168898: Toll-Like Receptors Cascades R-HSA-3700989: Transcriptional Regulation by TP53 R-HSA-2151201: Transcriptional activation of mitochondrial biogenesis

> KEGG and Reactome Pathway

[ TOP ]

KEGG

hsa04010 MAPK signaling pathway
hsa04022 cGMP-PKG signaling pathway
hsa04151 PI3K-Akt signaling pathway
hsa04261 Adrenergic signaling in cardiomyocytes
hsa04668 TNF signaling pathway
hsa04728 Dopaminergic synapse
hsa04911 Insulin secretion
hsa04915 Estrogen signaling pathway
hsa04918 Thyroid hormone synthesis
hsa04922 Glucagon signaling pathway

Reactome

R-HSA-166054: Activated TLR4 signalling
R-HSA-450341: Activation of the AP-1 family of transcription factors
R-HSA-3247509: Chromatin modifying enzymes
R-HSA-4839726: Chromatin organization
R-HSA-400253: Circadian Clock
R-HSA-74160: Gene Expression
R-HSA-212436: Generic Transcription Pathway
R-HSA-3214847: HATs acetylate histones
R-HSA-168256: Immune System
R-HSA-168249: Innate Immune System
R-HSA-450294: MAP kinase activation in TLR cascade
R-HSA-450282: MAPK targets/ Nuclear events mediated by MAP kinases
R-HSA-1592230: Mitochondrial biogenesis
R-HSA-975871: MyD88 cascade initiated on plasma membrane
R-HSA-975155: MyD88 dependent cascade initiated on endosome
R-HSA-166166: MyD88-independent TLR3/TLR4 cascade
R-HSA-166058: MyD88
R-HSA-1852241: Organelle biogenesis and maintenance
R-HSA-6796648: TP53 Regulates Transcription of DNA Repair Genes
R-HSA-168180: TRAF6 Mediated Induction of proinflammatory cytokines
R-HSA-975138: TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
R-HSA-937061: TRIF-mediated TLR3/TLR4 signaling
R-HSA-168142: Toll Like Receptor 10 (TLR10) Cascade
R-HSA-181438: Toll Like Receptor 2 (TLR2) Cascade
R-HSA-168164: Toll Like Receptor 3 (TLR3) Cascade
R-HSA-166016: Toll Like Receptor 4 (TLR4) Cascade
R-HSA-168176: Toll Like Receptor 5 (TLR5) Cascade
R-HSA-168181: Toll Like Receptor 7/8 (TLR7/8) Cascade
R-HSA-168138: Toll Like Receptor 9 (TLR9) Cascade
R-HSA-168179: Toll Like Receptor TLR1
R-HSA-168188: Toll Like Receptor TLR6
R-HSA-168898: Toll-Like Receptors Cascades
R-HSA-3700989: Transcriptional Regulation by TP53
R-HSA-2151201: Transcriptional activation of mitochondrial biogenesis

Summary
Symbol	ATF2
Name	activating transcription factor 2
Aliases	TREB7; CRE-BP1; HB16; cAMP responsive element binding protein 2; activating transcription factor 2 splice va ......
Location	2q31.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Mutation landscape in primary tumor tissue from TCGA > Mutation landscape in cancer cell line from CCLE > All mutations from COSMIC database V81 > Variations from text mining

> The Cancer Genome Atlas (TCGA) [ TOP ]

> Cancer Cell Line Encyclopedia (CCLE) [ TOP ]

> Catalogue of Somatic Mutations in Cancer (COSMIC)

[ TOP ]

COSMIC ID	CDS change	AA change	Mutation Type	Anatomical Site
COSM3709083	c.228G>A	p.L76L	Substitution - coding silent	Liver
COSM1401400	c.1367C>T	p.S456L	Substitution - Missense	Large_intestine
COSM1009808	c.730G>A	p.A244T	Substitution - Missense	Endometrium
COSM5727948	c.859C>T	p.P287S	Substitution - Missense	Skin
COSM1401400	c.1367C>T	p.S456L	Substitution - Missense	Skin
COSM1401405	c.132C>T	p.V44V	Substitution - coding silent	Large_intestine
COSM3787897	c.217A>G	p.T73A	Substitution - Missense	Pancreas
COSM717676	c.688G>T	p.A230S	Substitution - Missense	Lung
COSM84646	c.314A>C	p.K105T	Substitution - Missense	Pancreas
COSM95695	c.32+1G>T	p.?	Unknown	Lung
COSM3895375	c.1313C>T	p.S438L	Substitution - Missense	Skin
COSM4086885	c.944T>A	p.L315*	Substitution - Nonsense	Stomach
COSM3709083	c.228G>A	p.L76L	Substitution - coding silent	Liver
COSM441531	c.1501C>A	p.Q501K	Substitution - Missense	Breast
COSM2894235	c.321G>A	p.M107I	Substitution - Missense	Oesophagus
COSM5190781	c.1185G>T	p.Q395H	Substitution - Missense	Large_intestine
COSM5039122	c.681G>T	p.M227I	Substitution - Missense	Liver
COSM1291357	c.431C>T	p.T144I	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM84646	c.314A>C	p.K105T	Substitution - Missense	Pancreas
COSM1325749	c.877G>C	p.D293H	Substitution - Missense	Ovary
COSM3570155	c.862C>T	p.P288S	Substitution - Missense	Skin
COSM1305869	c.591A>G	p.V197V	Substitution - coding silent	Urinary_tract
COSM1009804	c.1359G>T	p.Q453H	Substitution - Missense	Endometrium
COSM3837454	c.1306G>A	p.D436N	Substitution - Missense	Breast
COSM2894209	c.1263C>T	p.T421T	Substitution - coding silent	Large_intestine
COSM1186056	c.806C>A	p.P269Q	Substitution - Missense	Lung
COSM5041348	c.1156G>C	p.D386H	Substitution - Missense	Liver
COSM4451296	c.1148A>T	p.K383I	Substitution - Missense	Skin
COSM3787897	c.217A>G	p.T73A	Substitution - Missense	Pancreas
COSM4748089	c.621_626+1delAATTGTG	p.?	Unknown	Stomach
COSM717678	c.1432A>T	p.T478S	Substitution - Missense	Lung
COSM1727041	c.667A>G	p.N223D	Substitution - Missense	Liver
COSM1009813	c.26C>A	p.S9Y	Substitution - Missense	Endometrium
COSM4968267	c.741+1G>C	p.?	Unknown	Adrenal_gland
COSM3895376	c.121C>T	p.H41Y	Substitution - Missense	Skin
COSM1660656	c.472C>T	p.Q158*	Substitution - Nonsense	Kidney
COSM3391136	c.1309A>G	p.S437G	Substitution - Missense	Pancreas
COSM4086887	c.133C>A	p.H45N	Substitution - Missense	Stomach
COSM717677	c.922G>C	p.E308Q	Substitution - Missense	Lung
COSM2894230	c.528T>C	p.L176L	Substitution - coding silent	Upper_aerodigestive_tract
COSM2894235	c.321G>A	p.M107I	Substitution - Missense	Large_intestine
COSM4567453	c.71_72CC>TT	p.P24L	Substitution - Missense	Skin
COSM1168906	c.373G>A	p.E125K	Substitution - Missense	Pancreas
COSM5058273	c.1081C>T	p.R361*	Substitution - Nonsense	Stomach
COSM2894227	c.548T>C	p.V183A	Substitution - Missense	Large_intestine
COSM5707873	c.901G>T	p.G301*	Substitution - Nonsense	Haematopoietic_and_lymphoid_tissue
COSM4855674	c.1082G>A	p.R361Q	Substitution - Missense	Cervix
COSM5887661	c.976C>T	p.P326S	Substitution - Missense	Upper_aerodigestive_tract
COSM1471323	c.23A>T	p.N8I	Substitution - Missense	Prostate
COSM1401403	c.935C>T	p.P312L	Substitution - Missense	Kidney
COSM476241	c.888A>G	p.K296K	Substitution - coding silent	Kidney
COSM2894230	c.528T>C	p.L176L	Substitution - coding silent	Upper_aerodigestive_tract
COSM5605554	c.409C>T	p.P137S	Substitution - Missense	Lung
COSM32726	c.1054G>C	p.D352H	Substitution - Missense	Breast
COSM136288	c.272C>T	p.P91L	Substitution - Missense	Skin
COSM2894231	c.489T>C	p.I163I	Substitution - coding silent	Upper_aerodigestive_tract
COSM4086886	c.816A>G	p.S272S	Substitution - coding silent	Stomach
COSM5653236	c.499G>T	p.A167S	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM1293129	c.266C>T	p.A89V	Substitution - Missense	Large_intestine
COSM2894204	c.1332G>A	p.P444P	Substitution - coding silent	Large_intestine
COSM3837455	c.474G>C	p.Q158H	Substitution - Missense	Breast
COSM3771154	c.201T>G	p.D67E	Substitution - Missense	Pancreas
COSM3570154	c.929C>T	p.S310F	Substitution - Missense	Skin
COSM5092196	c.1292-4C>A	p.?	Unknown	Large_intestine
COSM3379865	c.1331C>A	p.P444Q	Substitution - Missense	Pancreas
COSM1009811	c.241G>T	p.E81*	Substitution - Nonsense	Endometrium
COSM2894225	c.561G>A	p.Q187Q	Substitution - coding silent	Upper_aerodigestive_tract
COSM5817140	c.336C>T	p.S112S	Substitution - coding silent	Liver
COSM1613720	c.33-2A>C	p.?	Unknown	Liver
COSM2894226	c.558G>A	p.Q186Q	Substitution - coding silent	Upper_aerodigestive_tract
COSM4186530	c.1246A>G	p.K416E	Substitution - Missense	Kidney
COSM1733616	c.1477G>A	p.V493I	Substitution - Missense	Breast
COSM2894217	c.933A>G	p.R311R	Substitution - coding silent	Large_intestine
COSM2894204	c.1332G>A	p.P444P	Substitution - coding silent	Stomach
COSM1009812	c.85G>T	p.A29S	Substitution - Missense	Endometrium
COSM1009809	c.705T>C	p.I235I	Substitution - coding silent	Endometrium
COSM1641709	c.318delA	p.M107fs*3	Deletion - Frameshift	Stomach
COSM1193921	c.794C>T	p.S265F	Substitution - Missense	Lung
COSM5601062	c.1476C>T	p.I492I	Substitution - coding silent	Skin
COSM476240	c.1000C>G	p.P334A	Substitution - Missense	Kidney
COSM392773	c.1119delG	p.V375fs*6	Deletion - Frameshift	Lung
COSM3570153	c.1088G>A	p.R363K	Substitution - Missense	Skin
COSM5137235	c.1231C>T	p.L411F	Substitution - Missense	Large_intestine
COSM1733616	c.1477G>A	p.V493I	Substitution - Missense	Pancreas
COSM1641709	c.318delA	p.M107fs*3	Deletion - Frameshift	Large_intestine
COSM4982251	c.221G>C	p.R74T	Substitution - Missense	Oesophagus
COSM3837456	c.225C>A	p.F75L	Substitution - Missense	Breast
COSM1009810	c.617G>T	p.R206M	Substitution - Missense	Endometrium
COSM1401404	c.772G>T	p.V258F	Substitution - Missense	Large_intestine
COSM4827481	c.1177C>T	p.Q393*	Substitution - Nonsense	Cervix
COSM5885340	c.744C>T	p.L248L	Substitution - coding silent	Urinary_tract
COSM271115	c.1398C>A	p.T466T	Substitution - coding silent	Large_intestine
COSM1401403	c.935C>T	p.P312L	Substitution - Missense	Large_intestine
COSM5605554	c.409C>T	p.P137S	Substitution - Missense	Skin
COSM5628461	c.1203G>T	p.L401L	Substitution - coding silent	Oesophagus
COSM4086888	c.114C>T	p.N38N	Substitution - coding silent	Stomach
COSM4572522	c.771T>G	p.S257R	Substitution - Missense	Skin
COSM336171	c.1517G>T	p.*506L	Nonstop extension	Lung
COSM2894227	c.548T>C	p.V183A	Substitution - Missense	Large_intestine
COSM5418323	c.59G>C	p.S20T	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM3570156	c.779G>A	p.G260E	Substitution - Missense	Skin
COSM1009807	c.799C>T	p.P267S	Substitution - Missense	Endometrium
COSM4401837	c.1248A>G	p.K416K	Substitution - coding silent	Skin
COSM4491465	c.380C>T	p.S127F	Substitution - Missense	Skin
COSM1325748	c.248G>A	p.G83D	Substitution - Missense	Ovary
COSM3709083	c.228G>A	p.L76L	Substitution - coding silent	Liver
COSM331277	c.317A>G	p.K106R	Substitution - Missense	Lung
COSM4627945	c.656T>C	p.L219S	Substitution - Missense	Large_intestine
COSM5736262	c.1005G>T	p.Q335H	Substitution - Missense	Small_intestine
COSM1613720	c.33-2A>C	p.?	Unknown	Liver
COSM5417715	c.88C>A	p.P30T	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM1009805	c.1241C>T	p.A414V	Substitution - Missense	Endometrium
COSM5649901	c.977C>T	p.P326L	Substitution - Missense	Oesophagus
COSM5620323	c.42G>T	p.K14N	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM1009806	c.931C>T	p.R311*	Substitution - Nonsense	Endometrium
COSM2894218	c.932G>A	p.R311Q	Substitution - Missense	Soft_tissue
COSM3731386	c.1117delA	p.R373fs*8	Deletion - Frameshift	Stomach
COSM5614978	c.991C>T	p.H331Y	Substitution - Missense	Lung

> Text Mining based Variations [ TOP ]
There is no record for ATF2.

Summary
Symbol	ATF2
Name	activating transcription factor 2
Aliases	TREB7; CRE-BP1; HB16; cAMP responsive element binding protein 2; activating transcription factor 2 splice va ......
Location	2q31.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Post-translational modification (PTM)

> Post-translational modification (PTM)

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Filter By:

Uniprot ID	Position	Amino Acid	Description	Upstream Enzyme	Affected By Mutation	Amino Acid Sequence Variant
P15336	62	S	Phosphoserine	VRK1	No	None detected
P15336	69	T	Phosphothreonine	MAPK11 and MAPK14	No	None detected
P15336	71	T	Phosphothreonine	MAPK1, MAPK3, MAPK11, MAPK12, MAPK14 and PLK3	No	None detected
P15336	73	T	Phosphothreonine	VRK1	No	None detected
P15336	90	S	Phosphoserine	-	No	None detected
P15336	112	S	Phosphoserine	-	No	None detected
P15336	116	T	Phosphothreonine	-	No	None detected
P15336	121	S	Phosphoserine	PKC/PRKCA and PKC/PRKCB	No	None detected
P15336	136	S	Phosphoserine	-	No	None detected
P15336	328	S	Phosphoserine	-	No	None detected
P15336	340	S	Phosphoserine	PKC/PRKCA and PKC/PRKCB	No	None detected
P15336	357	K	N6-acetyllysine	-	No	None detected
P15336	367	S	Phosphoserine	PKC/PRKCA and PKC/PRKCB	No	None detected
P15336	374	K	N6-acetyllysine	-	No	None detected
P15336	442	S	Phosphoserine	-	No	None detected
P15336	446	S	Phosphoserine	-	No	None detected
P15336	490	S	Phosphoserine	ATM	No	None detected
P15336	498	S	Phosphoserine	ATM	No	None detected

Summary
Symbol	ATF2
Name	activating transcription factor 2
Aliases	TREB7; CRE-BP1; HB16; cAMP responsive element binding protein 2; activating transcription factor 2 splice va ......
Location	2q31.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Expression analysis in primary tumor tissue from TCGA > Expression level in cancer cell line from CCLE > Expression level in human normal tissue from HPA > Text mining based expression change

> The Cancer Genome Atlas (TCGA)

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Differential expression analysis for cancers with more than 10 normal samples

Cancer	Full Name	# N	# T	Median (N)	Median (T)	LogFC	Adj. P	Status
BLCA	Bladder urothelial carcinoma	19	408	4.072	3.557	-0.363	0.14	NS
BRCA	Breast invasive carcinoma	112	1100	4.977	4.672	-0.353	2.52e-05	NS
CESC	Cervical and endocervical cancers	3	306	3.892	3.821	NA	NA	NA
COAD	Colon adenocarcinoma	41	459	4.314	4.078	-0.3	0.000465	NS
ESCA	Esophageal carcinoma	11	185	5.016	4.858	-0.018	0.942	NS
GBM	Glioblastoma multiforme	5	166	5.264	4.645	NA	NA	NA
HNSC	Head and Neck squamous cell carcinoma	44	522	3.825	4.069	0.152	0.353	NS
KIRC	Kidney renal clear cell carcinoma	72	534	5.106	4.89	-0.401	3.89e-05	NS
KIRP	Kidney renal papillary cell carcinoma	32	291	4.763	4.254	-0.7	0.000832	Under
LAML	Acute Myeloid Leukemia	0	173	NA	5.676	NA	NA	NA
LGG	Brain Lower Grade Glioma	0	530	NA	4.832	NA	NA	NA
LIHC	Liver hepatocellular carcinoma	50	373	3.572	3.344	-0.23	0.214	NS
LUAD	Lung adenocarcinoma	59	517	4.312	4.535	0.136	0.103	NS
LUSC	Lung squamous cell carcinoma	51	501	4.375	4.501	0.1	0.196	NS
OV	Ovarian serous cystadenocarcinoma	0	307	NA	4.863	NA	NA	NA
PAAD	Pancreatic adenocarcinoma	4	179	4.197	4.281	NA	NA	NA
PCPG	Pheochromocytoma and Paraganglioma	3	184	4.154	4.139	NA	NA	NA
PRAD	Prostate adenocarcinoma	52	498	4.804	4.292	-0.553	8.06e-05	NS
READ	Rectum adenocarcinoma	10	167	4.188	4.035	-0.232	0.25	NS
SARC	Sarcoma	2	263	2.595	3.765	NA	NA	NA
SKCM	Skin Cutaneous Melanoma	1	472	4.067	4.328	NA	NA	NA
STAD	Stomach adenocarcinoma	35	415	4.853	4.925	0.001	0.995	NS
TGCT	Testicular Germ Cell Tumors	0	156	NA	4.036	NA	NA	NA
THCA	Thyroid carcinoma	59	509	5.158	4.449	-0.733	6.3e-08	Under
THYM	Thymoma	2	120	4.41	3.519	NA	NA	NA
UCEC	Uterine Corpus Endometrial Carcinoma	35	546	4.324	3.922	-0.465	0.00455	NS

> Cancer Cell Line Encyclopedia (CCLE)

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Tissue	Cell Line	Expression Level (Microarray)
Autonomic ganglia	CHP126	7.5
Autonomic ganglia	CHP212	5.6
Autonomic ganglia	IMR32	6.2
Autonomic ganglia	KELLY	7
Autonomic ganglia	KPNRTBM1	6.3
Autonomic ganglia	KPNSI9S	6.2
Autonomic ganglia	KPNYN	5.8
Autonomic ganglia	MHHNB11	9.6
Autonomic ganglia	NB1	7.5
Autonomic ganglia	NH6	5.5
Autonomic ganglia	SHSY5Y	7
Autonomic ganglia	SIMA	7.7
Autonomic ganglia	SKNAS	6.2
Autonomic ganglia	SKNBE2	5.6
Autonomic ganglia	SKNDZ	6.1
Autonomic ganglia	SKNFI	6.7
Autonomic ganglia	SKNSH	6.1
Biliary tract	HUCCT1	6.2
Biliary tract	HUH28	6.2
Biliary tract	SNU1079	6.1
Biliary tract	SNU1196	6.9
Biliary tract	SNU245	5.5
Biliary tract	SNU308	5.8
Biliary tract	SNU478	6
Bone	143B	6.1
Bone	A673	6.6
Bone	CADOES1	7.2
Bone	CAL78	6.5
Bone	G292CLONEA141B1	5.8
Bone	HOS	6.3
Bone	HS706T	6.5
Bone	HS737T	6
Bone	HS819T	5.9
Bone	HS821T	7.3
Bone	HS822T	5.1
Bone	HS863T	6.9
Bone	HS870T	6.2
Bone	HS888T	7.5
Bone	MG63	6.2
Bone	MHHES1	7.6
Bone	OUMS27	6.8
Bone	RDES	6.3
Bone	SJSA1	5.7
Bone	SKES1	6.9
Bone	SKNMC	6.7
Bone	SW1353	6
Bone	T173	6.2
Bone	TC71	6.4
Bone	U2OS	7.2
Breast	AU565	5.5
Breast	BT20	7.3
Breast	BT474	6
Breast	BT483	7.2
Breast	BT549	5.9
Breast	CAL120	6.7
Breast	CAL148	6.2
Breast	CAL51	7.8
Breast	CAL851	5
Breast	CAMA1	5
Breast	DU4475	6.3
Breast	EFM192A	5.8
Breast	EFM19	5.3
Breast	EVSAT	6.1
Breast	HCC1143	5.8
Breast	HCC1187	6.7
Breast	HCC1395	7.9
Breast	HCC1419	6.8
Breast	HCC1428	6.7
Breast	HCC1500	5.9
Breast	HCC1569	6
Breast	HCC1599	6.6
Breast	HCC1806	6.4
Breast	HCC1937	6.1
Breast	HCC1954	6.2
Breast	HCC202	4.7
Breast	HCC2157	4.9
Breast	HCC2218	4.2
Breast	HCC38	5.9
Breast	HCC70	5.9
Breast	HDQP1	6
Breast	HMC18	6.5
Breast	HS274T	7.5
Breast	HS281T	7.2
Breast	HS343T	7.3
Breast	HS578T	7.1
Breast	HS606T	5.9
Breast	HS739T	5.7
Breast	HS742T	5.9
Breast	JIMT1	5.4
Breast	KPL1	6.1
Breast	MCF7	5.9
Breast	MDAMB134VI	7.1
Breast	MDAMB157	7.2
Breast	MDAMB175VII	4.6
Breast	MDAMB231	5.8
Breast	MDAMB361	6
Breast	MDAMB415	5.3
Breast	MDAMB436	7.5
Breast	MDAMB453	6.2
Breast	MDAMB468	6.6
Breast	SKBR3	5
Breast	T47D	5.4
Breast	UACC812	4.8
Breast	UACC893	6.9
Breast	YMB1	5.4
Breast	ZR751	5.5
Breast	ZR7530	6.8
Central nervous system	1321N1	6.5
Central nervous system	42MGBA	7.4
Central nervous system	8MGBA	7
Central nervous system	A172	6.2
Central nervous system	AM38	6.9
Central nervous system	BECKER	6.2
Central nervous system	CAS1	6.2
Central nervous system	CCFSTTG1	6.1
Central nervous system	D283MED	6.9
Central nervous system	D341MED	6.1
Central nervous system	DAOY	6.6
Central nervous system	DBTRG05MG	5.6
Central nervous system	DKMG	5.7
Central nervous system	GAMG	6.5
Central nervous system	GB1	6.4
Central nervous system	GI1	6.2
Central nervous system	GMS10	6.3
Central nervous system	GOS3	5.9
Central nervous system	H4	6.7
Central nervous system	HS683	5.8
Central nervous system	KALS1	5.4
Central nervous system	KG1C	5.7
Central nervous system	KNS42	7.3
Central nervous system	KNS60	6.2
Central nervous system	KNS81	6.1
Central nervous system	KS1	6.4
Central nervous system	LN18	7.3
Central nervous system	LN229	5.9
Central nervous system	M059K	6.4
Central nervous system	MOGGCCM	5.9
Central nervous system	MOGGUVW	6.3
Central nervous system	NMCG1	5.7
Central nervous system	ONS76	5.8
Central nervous system	SF126	6.4
Central nervous system	SF295	5.8
Central nervous system	SNB19	6.6
Central nervous system	SNU1105	6.5
Central nervous system	SNU201	6.2
Central nervous system	SNU466	5.8
Central nervous system	SNU489	7.1
Central nervous system	SNU626	5.6
Central nervous system	SNU738	5.9
Central nervous system	SW1088	6.1
Central nervous system	SW1783	5.3
Central nervous system	T98G	7.9
Central nervous system	TM31	6.5
Central nervous system	U118MG	7.3
Central nervous system	U138MG	6.9
Central nervous system	U251MG	6.6
Central nervous system	U87MG	6.5
Central nervous system	YH13	6.4
Central nervous system	YKG1	5.8
Endometrium	AN3CA	5.9
Endometrium	COLO684	7.8
Endometrium	EFE184	4.6
Endometrium	EN	6.4
Endometrium	ESS1	6.2
Endometrium	HEC108	6.3
Endometrium	HEC151	5.6
Endometrium	HEC1A	5.6
Endometrium	HEC1B	7
Endometrium	HEC251	6.4
Endometrium	HEC265	5.4
Endometrium	HEC50B	6.7
Endometrium	HEC59	5.1
Endometrium	HEC6	7.3
Endometrium	ISHIKAWAHERAKLIO02ER	6
Endometrium	JHUEM1	6.5
Endometrium	JHUEM2	7.1
Endometrium	JHUEM3	5.4
Endometrium	KLE	6
Endometrium	MFE280	5.5
Endometrium	MFE296	6.5
Endometrium	MFE319	5.4
Endometrium	RL952	5.3
Endometrium	SNGM	6.6
Endometrium	SNU1077	6.6
Endometrium	SNU685	7.2
Endometrium	TEN	6.3
Haematopoietic and lymphoid	697	8.1
Haematopoietic and lymphoid	A3KAW	7.5
Haematopoietic and lymphoid	A4FUK	7.1
Haematopoietic and lymphoid	ALLSIL	7.1
Haematopoietic and lymphoid	AML193	6.2
Haematopoietic and lymphoid	AMO1	7.6
Haematopoietic and lymphoid	BCP1	7.3
Haematopoietic and lymphoid	BDCM	6.4
Haematopoietic and lymphoid	BL41	6.6
Haematopoietic and lymphoid	BL70	6
Haematopoietic and lymphoid	BV173	8.3
Haematopoietic and lymphoid	CA46	6.7
Haematopoietic and lymphoid	CI1	6.6
Haematopoietic and lymphoid	CMK115	7.3
Haematopoietic and lymphoid	CMK86	7.8
Haematopoietic and lymphoid	CMK	7.1
Haematopoietic and lymphoid	CMLT1	7.4
Haematopoietic and lymphoid	COLO775	8.3
Haematopoietic and lymphoid	DAUDI	7
Haematopoietic and lymphoid	DB	6.2
Haematopoietic and lymphoid	DEL	7.9
Haematopoietic and lymphoid	DND41	7.7
Haematopoietic and lymphoid	DOHH2	6.6
Haematopoietic and lymphoid	EB1	6.8
Haematopoietic and lymphoid	EB2	7.1
Haematopoietic and lymphoid	EHEB	7.1
Haematopoietic and lymphoid	EJM	8.4
Haematopoietic and lymphoid	EM2	8.2
Haematopoietic and lymphoid	EOL1	6.9
Haematopoietic and lymphoid	F36P	8
Haematopoietic and lymphoid	GA10	6.6
Haematopoietic and lymphoid	GDM1	7
Haematopoietic and lymphoid	GRANTA519	7.3
Haematopoietic and lymphoid	HDLM2	6.7
Haematopoietic and lymphoid	HDMYZ	6.1
Haematopoietic and lymphoid	HEL9217	7.3
Haematopoietic and lymphoid	HEL	6.8
Haematopoietic and lymphoid	HH	6.4
Haematopoietic and lymphoid	HL60	4.7
Haematopoietic and lymphoid	HPBALL	7.5
Haematopoietic and lymphoid	HS604T	5.8
Haematopoietic and lymphoid	HS611T	6.6
Haematopoietic and lymphoid	HS616T	6.1
Haematopoietic and lymphoid	HS751T	5.8
Haematopoietic and lymphoid	HT	7.5
Haematopoietic and lymphoid	HTK	7.2
Haematopoietic and lymphoid	HUNS1	6.2
Haematopoietic and lymphoid	HUT102	6.5
Haematopoietic and lymphoid	HUT78	5.5
Haematopoietic and lymphoid	JEKO1	6.2
Haematopoietic and lymphoid	JK1	6.5
Haematopoietic and lymphoid	JM1	6.6
Haematopoietic and lymphoid	JURKAT	8
Haematopoietic and lymphoid	JURLMK1	7.5
Haematopoietic and lymphoid	JVM2	7.5
Haematopoietic and lymphoid	JVM3	7.3
Haematopoietic and lymphoid	K562	7
Haematopoietic and lymphoid	KARPAS299	6.7
Haematopoietic and lymphoid	KARPAS422	7.4
Haematopoietic and lymphoid	KARPAS620	7.1
Haematopoietic and lymphoid	KASUMI1	6.5
Haematopoietic and lymphoid	KASUMI2	7.3
Haematopoietic and lymphoid	KASUMI6	7.5
Haematopoietic and lymphoid	KCL22	7.8
Haematopoietic and lymphoid	KE37	7.1
Haematopoietic and lymphoid	KE97	6.6
Haematopoietic and lymphoid	KG1	6.6
Haematopoietic and lymphoid	KHM1B	5.6
Haematopoietic and lymphoid	KIJK	6.7
Haematopoietic and lymphoid	KMH2	7.4
Haematopoietic and lymphoid	KMM1	6.9
Haematopoietic and lymphoid	KMS11	7
Haematopoietic and lymphoid	KMS12BM	6.6
Haematopoietic and lymphoid	KMS18	6.5
Haematopoietic and lymphoid	KMS20	7
Haematopoietic and lymphoid	KMS21BM	6.9
Haematopoietic and lymphoid	KMS26	6.8
Haematopoietic and lymphoid	KMS27	6.6
Haematopoietic and lymphoid	KMS28BM	6.3
Haematopoietic and lymphoid	KMS34	6.3
Haematopoietic and lymphoid	KO52	6.5
Haematopoietic and lymphoid	KOPN8	6.5
Haematopoietic and lymphoid	KU812	7.4
Haematopoietic and lymphoid	KYO1	7.5
Haematopoietic and lymphoid	L1236	6
Haematopoietic and lymphoid	L363	7.7
Haematopoietic and lymphoid	L428	8.2
Haematopoietic and lymphoid	L540	7.8
Haematopoietic and lymphoid	LAMA84	7.2
Haematopoietic and lymphoid	LOUCY	6.6
Haematopoietic and lymphoid	LP1	6
Haematopoietic and lymphoid	M07E	7.5
Haematopoietic and lymphoid	MC116	6.5
Haematopoietic and lymphoid	ME1	5.7
Haematopoietic and lymphoid	MEC1	8
Haematopoietic and lymphoid	MEC2	7.5
Haematopoietic and lymphoid	MEG01	6.9
Haematopoietic and lymphoid	MHHCALL2	7.5
Haematopoietic and lymphoid	MHHCALL3	7.1
Haematopoietic and lymphoid	MHHCALL4	7.3
Haematopoietic and lymphoid	MINO	7.5
Haematopoietic and lymphoid	MJ	6.9
Haematopoietic and lymphoid	MM1S	6.7
Haematopoietic and lymphoid	MOLM13	6.5
Haematopoietic and lymphoid	MOLM16	7.5
Haematopoietic and lymphoid	MOLM6	7.2
Haematopoietic and lymphoid	MOLP2	6.9
Haematopoietic and lymphoid	MOLP8	8.4
Haematopoietic and lymphoid	MOLT13	7.8
Haematopoietic and lymphoid	MOLT16	7.3
Haematopoietic and lymphoid	MOLT4	7.8
Haematopoietic and lymphoid	MONOMAC1	7
Haematopoietic and lymphoid	MONOMAC6	7.3
Haematopoietic and lymphoid	MOTN1	7.3
Haematopoietic and lymphoid	MUTZ5	7.2
Haematopoietic and lymphoid	MV411	6.2
Haematopoietic and lymphoid	NALM19	7.6
Haematopoietic and lymphoid	NALM1	7.6
Haematopoietic and lymphoid	NALM6	7.6
Haematopoietic and lymphoid	NAMALWA	6.7
Haematopoietic and lymphoid	NB4	8.2
Haematopoietic and lymphoid	NCIH929	5.8
Haematopoietic and lymphoid	NCO2	6.8
Haematopoietic and lymphoid	NOMO1	6.6
Haematopoietic and lymphoid	NUDHL1	7
Haematopoietic and lymphoid	NUDUL1	7.1
Haematopoietic and lymphoid	OCIAML2	7.3
Haematopoietic and lymphoid	OCIAML3	7.4
Haematopoietic and lymphoid	OCIAML5	6.9
Haematopoietic and lymphoid	OCILY10	6.8
Haematopoietic and lymphoid	OCILY19	7.9
Haematopoietic and lymphoid	OCILY3	6.5
Haematopoietic and lymphoid	OCIM1	8.2
Haematopoietic and lymphoid	OPM2	8
Haematopoietic and lymphoid	P12ICHIKAWA	8
Haematopoietic and lymphoid	P31FUJ	5.8
Haematopoietic and lymphoid	P3HR1	6.1
Haematopoietic and lymphoid	PCM6	7.7
Haematopoietic and lymphoid	PEER	7
Haematopoietic and lymphoid	PF382	8
Haematopoietic and lymphoid	PFEIFFER	7.6
Haematopoietic and lymphoid	PL21	7.1
Haematopoietic and lymphoid	RAJI	6.2
Haematopoietic and lymphoid	RCHACV	7.6
Haematopoietic and lymphoid	REC1	6.2
Haematopoietic and lymphoid	REH	6.8
Haematopoietic and lymphoid	RI1	6.3
Haematopoietic and lymphoid	RL	6.8
Haematopoietic and lymphoid	RPMI8226	6.2
Haematopoietic and lymphoid	RPMI8402	8.2
Haematopoietic and lymphoid	RS411	6.2
Haematopoietic and lymphoid	SEM	6
Haematopoietic and lymphoid	SET2	7.4
Haematopoietic and lymphoid	SIGM5	7.7
Haematopoietic and lymphoid	SKM1	6.3
Haematopoietic and lymphoid	SKMM2	7.6
Haematopoietic and lymphoid	SR786	7.8
Haematopoietic and lymphoid	ST486	6.5
Haematopoietic and lymphoid	SUDHL10	7.1
Haematopoietic and lymphoid	SUDHL1	6.9
Haematopoietic and lymphoid	SUDHL4	6.3
Haematopoietic and lymphoid	SUDHL5	7.4
Haematopoietic and lymphoid	SUDHL6	7.7
Haematopoietic and lymphoid	SUDHL8	6.7
Haematopoietic and lymphoid	SUPB15	6.2
Haematopoietic and lymphoid	SUPHD1	6.9
Haematopoietic and lymphoid	SUPM2	6.6
Haematopoietic and lymphoid	SUPT11	7.5
Haematopoietic and lymphoid	SUPT1	6.9
Haematopoietic and lymphoid	TALL1	7.3
Haematopoietic and lymphoid	TF1	8
Haematopoietic and lymphoid	THP1	7.2
Haematopoietic and lymphoid	TO175T	5.8
Haematopoietic and lymphoid	TOLEDO	6.3
Haematopoietic and lymphoid	U266B1	7.2
Haematopoietic and lymphoid	U937	7
Haematopoietic and lymphoid	UT7	7.2
Haematopoietic and lymphoid	WSUDLCL2	7.6
Kidney	769P	6.9
Kidney	786O	6.8
Kidney	A498	6.8
Kidney	A704	7.2
Kidney	ACHN	6.6
Kidney	BFTC909	7.7
Kidney	CAKI1	6.6
Kidney	CAKI2	6.5
Kidney	CAL54	7
Kidney	KMRC1	6.8
Kidney	KMRC20	6.6
Kidney	KMRC2	6.1
Kidney	KMRC3	5.8
Kidney	OSRC2	5.9
Kidney	RCC10RGB	6.7
Kidney	SNU1272	6.1
Kidney	SNU349	7.4
Kidney	TUHR10TKB	6.8
Kidney	TUHR14TKB	6.1
Kidney	TUHR4TKB	6.1
Kidney	VMRCRCW	6.7
Kidney	VMRCRCZ	8.1
Large intestine	C2BBE1	6.7
Large intestine	CCK81	6.3
Large intestine	CL11	6.9
Large intestine	CL14	6.3
Large intestine	CL34	7.2
Large intestine	CL40	5.7
Large intestine	COLO205	5.6
Large intestine	COLO320	7.3
Large intestine	COLO678	6.1
Large intestine	CW2	6.2
Large intestine	DLD1	6.3
Large intestine	GP2D	5.6
Large intestine	HCC56	5
Large intestine	HCT116	6.1
Large intestine	HCT15	6.2
Large intestine	HS675T	5.8
Large intestine	HS698T	7
Large intestine	HT115	5.3
Large intestine	HT29	6.3
Large intestine	HT55	5.9
Large intestine	KM12	7.2
Large intestine	LOVO	5.9
Large intestine	LS1034	5.2
Large intestine	LS123	5.1
Large intestine	LS180	5.8
Large intestine	LS411N	6.3
Large intestine	LS513	4.7
Large intestine	MDST8	6.6
Large intestine	NCIH508	5.6
Large intestine	NCIH716	6.1
Large intestine	NCIH747	4.7
Large intestine	OUMS23	5.9
Large intestine	RCM1	5.4
Large intestine	RKO	5.6
Large intestine	SKCO1	5.4
Large intestine	SNU1040	5.8
Large intestine	SNU1197	5.8
Large intestine	SNU175	6.4
Large intestine	SNU283	5.4
Large intestine	SNU407	6.4
Large intestine	SNU503	5.7
Large intestine	SNU61	6
Large intestine	SNU81	6.5
Large intestine	SNUC1	4.3
Large intestine	SNUC2A	4.6
Large intestine	SNUC4	5.6
Large intestine	SNUC5	6
Large intestine	SW1116	4.8
Large intestine	SW1417	5.9
Large intestine	SW1463	5.1
Large intestine	SW403	5.4
Large intestine	SW480	5.7
Large intestine	SW48	5.8
Large intestine	SW620	6.5
Large intestine	SW837	5.3
Large intestine	SW948	5.9
Large intestine	T84	5.2
Liver	ALEXANDERCELLS	6.2
Liver	C3A	6.9
Liver	HEP3B217	6.8
Liver	HEPG2	7.6
Liver	HLE	5.6
Liver	HLF	6
Liver	HUH1	7.3
Liver	HUH6	6.4
Liver	HUH7	7.2
Liver	JHH1	5.5
Liver	JHH2	6.4
Liver	JHH4	6.1
Liver	JHH5	6.7
Liver	JHH6	7.3
Liver	JHH7	6.1
Liver	LI7	5.8
Liver	PLCPRF5	6.8
Liver	SKHEP1	5.9
Liver	SNU182	6.8
Liver	SNU387	7.1
Liver	SNU398	7.6
Liver	SNU423	6.7
Liver	SNU449	6.5
Liver	SNU475	6.7
Liver	SNU761	5.8
Liver	SNU878	7.2
Liver	SNU886	7.9
Lung	A549	5.6
Lung	ABC1	5.2
Lung	BEN	8
Lung	CAL12T	5.7
Lung	CALU1	6.4
Lung	CALU3	7.2
Lung	CALU6	6.3
Lung	CHAGOK1	6.3
Lung	COLO668	6.5
Lung	COLO699	6.5
Lung	CORL105	6.3
Lung	CORL23	5.6
Lung	CORL24	7.1
Lung	CORL279	7.8
Lung	CORL311	6.8
Lung	CORL47	6.5
Lung	CORL51	6.6
Lung	CORL88	7.3
Lung	CORL95	6.4
Lung	CPCN	5.4
Lung	DMS114	5.7
Lung	DMS153	5.9
Lung	DMS273	6.5
Lung	DMS454	7
Lung	DMS53	6.8
Lung	DMS79	7.3
Lung	DV90	5.4
Lung	EBC1	5
Lung	EPLC272H	5.8
Lung	HARA	6.4
Lung	HCC1171	6.1
Lung	HCC1195	5.6
Lung	HCC15	6.4
Lung	HCC2279	6.8
Lung	HCC2935	7.1
Lung	HCC33	6.5
Lung	HCC366	6.8
Lung	HCC4006	7
Lung	HCC44	5.4
Lung	HCC78	5.1
Lung	HCC827	6.7
Lung	HCC95	5.5
Lung	HLC1	6.1
Lung	HLFA	6.2
Lung	HS229T	6.3
Lung	HS618T	6
Lung	IALM	6.5
Lung	KNS62	6
Lung	LC1F	5.9
Lung	LC1SQSF	6.8
Lung	LCLC103H	7.6
Lung	LCLC97TM1	7.1
Lung	LK2	6.7
Lung	LOUNH91	6
Lung	LU65	6.2
Lung	LU99	6.9
Lung	LUDLU1	6.3
Lung	LXF289	7.1
Lung	MORCPR	6
Lung	NCIH1048	5.4
Lung	NCIH1092	5.9
Lung	NCIH1105	6.8
Lung	NCIH1155	6.6
Lung	NCIH1184	6.2
Lung	NCIH1299	6.2
Lung	NCIH1339	7.3
Lung	NCIH1341	6.2
Lung	NCIH1355	6.2
Lung	NCIH1373	5.4
Lung	NCIH1385	7.6
Lung	NCIH1395	5.3
Lung	NCIH1435	6.8
Lung	NCIH1436	7.1
Lung	NCIH1437	5.9
Lung	NCIH146	5.8
Lung	NCIH1563	6.5
Lung	NCIH1568	5.8
Lung	NCIH1573	6.2
Lung	NCIH1581	6.4
Lung	NCIH1618	5.8
Lung	NCIH1623	5.1
Lung	NCIH1648	4.6
Lung	NCIH1650	5.8
Lung	NCIH1651	6.2
Lung	NCIH1666	5.2
Lung	NCIH1693	7.3
Lung	NCIH1694	6.5
Lung	NCIH1703	7.1
Lung	NCIH1734	5.8
Lung	NCIH1755	6.6
Lung	NCIH1781	5.7
Lung	NCIH1792	5.3
Lung	NCIH1793	6.8
Lung	NCIH1836	6
Lung	NCIH1838	5.6
Lung	NCIH1869	6.7
Lung	NCIH1876	6.4
Lung	NCIH1915	7.7
Lung	NCIH1930	6.4
Lung	NCIH1944	8
Lung	NCIH1963	6.2
Lung	NCIH196	7.4
Lung	NCIH1975	6.6
Lung	NCIH2009	7.2
Lung	NCIH2023	5.2
Lung	NCIH2029	6.2
Lung	NCIH2030	8.1
Lung	NCIH2066	6.1
Lung	NCIH2081	6.4
Lung	NCIH2085	6.7
Lung	NCIH2087	6.1
Lung	NCIH209	6.6
Lung	NCIH2106	7.8
Lung	NCIH2110	5.9
Lung	NCIH211	7
Lung	NCIH2122	5.2
Lung	NCIH2126	6.3
Lung	NCIH2141	7.3
Lung	NCIH2170	6.1
Lung	NCIH2171	7
Lung	NCIH2172	6.2
Lung	NCIH2196	6.6
Lung	NCIH2227	6.2
Lung	NCIH2228	6.1
Lung	NCIH226	6.1
Lung	NCIH2286	6.7
Lung	NCIH2291	5
Lung	NCIH2342	6.8
Lung	NCIH2347	5.3
Lung	NCIH23	6.2
Lung	NCIH2405	7.3
Lung	NCIH2444	5.9
Lung	NCIH292	6.5
Lung	NCIH322	5.5
Lung	NCIH3255	6.5
Lung	NCIH358	6.6
Lung	NCIH441	6.6
Lung	NCIH446	7.1
Lung	NCIH460	5.5
Lung	NCIH510	7.5
Lung	NCIH520	6.6
Lung	NCIH522	7
Lung	NCIH524	6.2
Lung	NCIH526	6.4
Lung	NCIH596	7.4
Lung	NCIH647	6.6
Lung	NCIH650	6.8
Lung	NCIH661	6.4
Lung	NCIH69	5.5
Lung	NCIH727	7.8
Lung	NCIH810	6.2
Lung	NCIH82	7.6
Lung	NCIH838	7.8
Lung	NCIH841	7.3
Lung	NCIH854	6.5
Lung	NCIH889	6.6
Lung	PC14	6
Lung	RERFLCAD1	6.2
Lung	RERFLCAD2	5.2
Lung	RERFLCAI	6.3
Lung	RERFLCKJ	5.4
Lung	RERFLCMS	6.3
Lung	RERFLCSQ1	6.7
Lung	SBC5	7.1
Lung	SCLC21H	8.5
Lung	SHP77	6.6
Lung	SKLU1	5.3
Lung	SKMES1	6.8
Lung	SQ1	6.3
Lung	SW1271	7
Lung	SW1573	6.2
Lung	SW900	6.4
Lung	VMRCLCD	8
Lung	VMRCLCP	6.2
Oesophagus	COLO680N	6.7
Oesophagus	ECGI10	6.6
Oesophagus	KYSE140	5.1
Oesophagus	KYSE150	5.8
Oesophagus	KYSE180	5.2
Oesophagus	KYSE270	5.3
Oesophagus	KYSE30	5.5
Oesophagus	KYSE410	5.7
Oesophagus	KYSE450	6
Oesophagus	KYSE510	6.7
Oesophagus	KYSE520	6.6
Oesophagus	KYSE70	6.1
Oesophagus	OE19	5.8
Oesophagus	OE33	5.4
Oesophagus	TE10	6.3
Oesophagus	TE11	6
Oesophagus	TE14	6
Oesophagus	TE15	5.7
Oesophagus	TE1	5.7
Oesophagus	TE4	5.5
Oesophagus	TE5	5.9
Oesophagus	TE6	5.5
Oesophagus	TE8	5.4
Oesophagus	TE9	5.8
Oesophagus	TT	6.6
Ovary	59M	8
Ovary	A2780	7.6
Ovary	CAOV3	7.2
Ovary	CAOV4	6.2
Ovary	COLO704	7.2
Ovary	COV318	6.8
Ovary	COV362	7.2
Ovary	COV434	6.4
Ovary	COV504	6.7
Ovary	COV644	5.8
Ovary	EFO21	7.1
Ovary	EFO27	6.5
Ovary	ES2	5.9
Ovary	FUOV1	6.2
Ovary	HEYA8	6.1
Ovary	HS571T	6.6
Ovary	IGROV1	7.1
Ovary	JHOC5	7.3
Ovary	JHOM1	5.7
Ovary	JHOM2B	6.9
Ovary	JHOS2	6.6
Ovary	JHOS4	6.2
Ovary	KURAMOCHI	8.2
Ovary	MCAS	6.5
Ovary	NIHOVCAR3	5.5
Ovary	OAW28	6.1
Ovary	OAW42	6.2
Ovary	OC314	5.9
Ovary	OC316	6.1
Ovary	ONCODG1	5.9
Ovary	OV56	6.7
Ovary	OV7	6.5
Ovary	OV90	5.8
Ovary	OVCAR4	5.3
Ovary	OVCAR8	5.9
Ovary	OVISE	4.6
Ovary	OVK18	6.3
Ovary	OVKATE	7.1
Ovary	OVMANA	6.5
Ovary	OVSAHO	6.7
Ovary	OVTOKO	6.6
Ovary	RMGI	6.4
Ovary	RMUGS	5.9
Ovary	SKOV3	6.6
Ovary	SNU119	6.3
Ovary	SNU840	6.3
Ovary	SNU8	6.1
Ovary	TOV112D	7
Ovary	TOV21G	6.3
Ovary	TYKNU	7.2
Pancreas	ASPC1	7.6
Pancreas	BXPC3	5.8
Pancreas	CAPAN1	5.5
Pancreas	CAPAN2	7.1
Pancreas	CFPAC1	6.5
Pancreas	DANG	5.6
Pancreas	HPAC	6.5
Pancreas	HPAFII	5.8
Pancreas	HS766T	6.1
Pancreas	HUPT3	5.2
Pancreas	HUPT4	5.9
Pancreas	KCIMOH1	6.8
Pancreas	KLM1	6.7
Pancreas	KP2	6.4
Pancreas	KP3	7.1
Pancreas	KP4	6.9
Pancreas	L33	6.6
Pancreas	MIAPACA2	6.5
Pancreas	PANC0203	5.8
Pancreas	PANC0213	5.9
Pancreas	PANC0327	5.3
Pancreas	PANC0403	6.3
Pancreas	PANC0504	5.5
Pancreas	PANC0813	5.8
Pancreas	PANC1005	6.7
Pancreas	PANC1	6.3
Pancreas	PATU8902	6
Pancreas	PATU8988S	5.1
Pancreas	PATU8988T	6.8
Pancreas	PK1	5.8
Pancreas	PK45H	6.2
Pancreas	PK59	5.9
Pancreas	PL45	5.6
Pancreas	PSN1	5.8
Pancreas	QGP1	5.9
Pancreas	SNU213	6.3
Pancreas	SNU324	6
Pancreas	SNU410	6.3
Pancreas	SU8686	6.6
Pancreas	SUIT2	6
Pancreas	SW1990	6.8
Pancreas	T3M4	5.2
Pancreas	TCCPAN2	7.2
Pancreas	YAPC	6.2
Pleura	ACCMESO1	7.5
Pleura	DM3	6.2
Pleura	ISTMES1	6.1
Pleura	ISTMES2	6.4
Pleura	JL1	7.5
Pleura	MPP89	6.6
Pleura	MSTO211H	5.6
Pleura	NCIH2052	7
Pleura	NCIH2452	5.7
Pleura	NCIH28	6.3
Prostate	22RV1	4.9
Prostate	DU145	5.9
Prostate	LNCAPCLONEFGC	6.1
Prostate	MDAPCA2B	6
Prostate	NCIH660	4.7
Prostate	PC3	5.5
Prostate	VCAP	5.9
Salivary gland	A253	6
Salivary gland	YD15	6.6
Skin	A101D	6.1
Skin	A2058	7.3
Skin	A375	5.8
Skin	C32	5.3
Skin	CHL1	7.2
Skin	CJM	6.3
Skin	COLO679	6.5
Skin	COLO741	5.9
Skin	COLO783	6.7
Skin	COLO792	4.9
Skin	COLO800	6.2
Skin	COLO818	6.3
Skin	COLO829	6.3
Skin	COLO849	5.5
Skin	G361	5.8
Skin	GRM	6.5
Skin	HMCB	7.8
Skin	HS294T	6.3
Skin	HS600T	5.7
Skin	HS688AT	5.8
Skin	HS695T	6.4
Skin	HS839T	5.4
Skin	HS852T	6.7
Skin	HS895T	5.9
Skin	HS934T	7.3
Skin	HS936T	5.4
Skin	HS939T	6.3
Skin	HS940T	5.8
Skin	HS944T	6.2
Skin	HT144	6
Skin	IGR1	6.1
Skin	IGR37	6
Skin	IGR39	5.7
Skin	IPC298	6.8
Skin	K029AX	6.4
Skin	LOXIMVI	7.4
Skin	MALME3M	6.1
Skin	MDAMB435S	7
Skin	MELHO	5.5
Skin	MELJUSO	5.5
Skin	MEWO	7.1
Skin	RPMI7951	7.4
Skin	RVH421	5.6
Skin	SH4	5.7
Skin	SKMEL1	5.6
Skin	SKMEL24	6.5
Skin	SKMEL28	6.2
Skin	SKMEL2	5.3
Skin	SKMEL30	6.2
Skin	SKMEL31	5.3
Skin	SKMEL3	6.3
Skin	SKMEL5	5.8
Skin	UACC257	6.1
Skin	UACC62	6.2
Skin	WM115	6.3
Skin	WM1799	6.8
Skin	WM2664	6.3
Skin	WM793	7.1
Skin	WM88	6.9
Skin	WM983B	6.3
Small intestine	HUTU80	6.1
Soft tissue	A204	5.9
Soft tissue	G401	7.1
Soft tissue	G402	6.8
Soft tissue	GCT	7.3
Soft tissue	HS729	5.4
Soft tissue	HT1080	6.1
Soft tissue	KYM1	5.9
Soft tissue	MESSA	7.1
Soft tissue	RD	7.6
Soft tissue	RH30	6.1
Soft tissue	RH41	7.2
Soft tissue	RKN	6.1
Soft tissue	S117	7.4
Soft tissue	SJRH30	5.9
Soft tissue	SKLMS1	5.3
Soft tissue	SKUT1	6.5
Soft tissue	TE125T	7.1
Soft tissue	TE159T	4.7
Soft tissue	TE441T	7.2
Soft tissue	TE617T	6.6
Stomach	2313287	7
Stomach	AGS	6.5
Stomach	AZ521	6.5
Stomach	ECC10	6.5
Stomach	ECC12	7.1
Stomach	FU97	7.2
Stomach	GCIY	5.5
Stomach	GSS	7
Stomach	GSU	5.7
Stomach	HGC27	7
Stomach	HS746T	6.4
Stomach	HUG1N	6.2
Stomach	IM95	6.4
Stomach	KATOIII	5.1
Stomach	KE39	7.3
Stomach	LMSU	6.7
Stomach	MKN1	6.4
Stomach	MKN45	6.9
Stomach	MKN74	6.5
Stomach	MKN7	7.1
Stomach	NCCSTCK140	6.7
Stomach	NCIN87	5.6
Stomach	NUGC2	6
Stomach	NUGC3	6.8
Stomach	NUGC4	6.1
Stomach	OCUM1	5.8
Stomach	RERFGC1B	6
Stomach	SH10TC	6.1
Stomach	SNU16	5.3
Stomach	SNU1	5.5
Stomach	SNU216	7.3
Stomach	SNU520	6.1
Stomach	SNU5	6.6
Stomach	SNU601	6.9
Stomach	SNU620	5.1
Stomach	SNU668	7.7
Stomach	SNU719	6.6
Stomach	TGBC11TKB	6.3
Thyroid	8305C	7.1
Thyroid	8505C	7.2
Thyroid	BCPAP	7.7
Thyroid	BHT101	7.1
Thyroid	CAL62	7.3
Thyroid	CGTHW1	6.3
Thyroid	FTC133	5.9
Thyroid	FTC238	5.5
Thyroid	ML1	7.8
Thyroid	SW579	6.3
Thyroid	TT2609C02	7.4
Thyroid	TT	7.1
Upper aerodigestive tract	BHY	5.9
Upper aerodigestive tract	BICR16	6.3
Upper aerodigestive tract	BICR18	4.9
Upper aerodigestive tract	BICR22	4.8
Upper aerodigestive tract	BICR31	5.8
Upper aerodigestive tract	BICR56	5.4
Upper aerodigestive tract	BICR6	5.2
Upper aerodigestive tract	CAL27	6.7
Upper aerodigestive tract	CAL33	6.8
Upper aerodigestive tract	DETROIT562	7.8
Upper aerodigestive tract	FADU	7.3
Upper aerodigestive tract	HS840T	6.1
Upper aerodigestive tract	HSC2	6.1
Upper aerodigestive tract	HSC3	6.1
Upper aerodigestive tract	HSC4	6
Upper aerodigestive tract	PECAPJ15	5.9
Upper aerodigestive tract	PECAPJ34CLONEC12	5.9
Upper aerodigestive tract	PECAPJ41CLONED2	6.9
Upper aerodigestive tract	PECAPJ49	6.7
Upper aerodigestive tract	SCC15	6.3
Upper aerodigestive tract	SCC25	6.1
Upper aerodigestive tract	SCC4	6.6
Upper aerodigestive tract	SCC9	5.2
Upper aerodigestive tract	SNU1076	5.6
Upper aerodigestive tract	SNU1214	5.4
Upper aerodigestive tract	SNU46	7.1
Upper aerodigestive tract	SNU899	6
Upper aerodigestive tract	YD10B	5.6
Upper aerodigestive tract	YD38	6.4
Upper aerodigestive tract	YD8	7
Urinary tract	5637	4.5
Urinary tract	639V	7.4
Urinary tract	647V	6.9
Urinary tract	BC3C	7.9
Urinary tract	BFTC905	6.5
Urinary tract	CAL29	6.4
Urinary tract	HS172T	7.3
Urinary tract	HT1197	4.8
Urinary tract	HT1376	5.5
Urinary tract	J82	6
Urinary tract	JMSU1	6.3
Urinary tract	KMBC2	6.3
Urinary tract	KU1919	7
Urinary tract	RT11284	6
Urinary tract	RT112	5.6
Urinary tract	RT4	5.2
Urinary tract	SCABER	6.3
Urinary tract	SW1710	7.2
Urinary tract	SW780	5.5
Urinary tract	T24	6.8
Urinary tract	TCCSUP	7.2
Urinary tract	UMUC1	6.3
Urinary tract	UMUC3	5.5
Urinary tract	VMCUB1	6.3

> The Human Protein Atlas (HPA)

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Tissue	Expression Level (TPM)
Adipose tissue	18.7
Adrenal gland	26.7
Appendix	21.1
Bone marrow	10.5
Breast	23.9
Cerebral cortex	42
Cervix, uterine	38.7
Colon	15.3
Duodenum	13.4
Endometrium	36.2
Epididymis	25.8
Esophagus	15.9
Fallopian tube	30.4
Gallbladder	28.2
Heart muscle	8.3
Kidney	23.9
Liver	14.1
Lung	23
Lymph node	22.9
Ovary	31.9
Pancreas	4
Parathyroid gland	36.2
Placenta	28.9
Prostate	28.9
Rectum	17.5
Salivary gland	7.6
Seminal vesicle	24.6
Skeletal muscle	4.3
Skin	11.9
Small intestine	15.2
Smooth muscle	26.2
Spleen	24.5
Stomach	13.2
Testis	38.7
Thyroid gland	53.7
Tonsil	20
Urinary bladder	21.1

> Text Mining based Expression

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PMID	Expression	Cancer	Evidence
27377902	overexpression	Renal Cell Carcinoma	Moreover, ATF2 was shown to be highly expressed in RCC tissues, especially in tumors with metastases.
26870280	overexpression	Non-Small Cell Lung Carcinoma	The results demonstrated that ATF2 was markedly overexpressed in the NSCLC cells and significantly overexpressed in the fresh NSCLC tissues compared with the control cells and samples (86 paraffin-embedded tissue sections), respectively (P<0.01).
26645581	overexpression	Melanoma	In contrast, increased expression of the gene encoding PKCε and abundance of phosphorylated, transcriptionally active ATF2 were observed in advanced-stage melanomas and correlated with decreased FUK expression, decreased cellular protein fucosylation, attenuated cell adhesion, and increased cell motility.
25961580	overexpression	Skin Neoplasm	In a promotable skin cell model, the nuclear levels of ATF2 were increased during tumor promotion, whereas this increase was inhibited by shikonin.
25359574	overexpression	Non-Small Cell Lung Carcinoma	Furthermore, in NSCLC cell lines, ATF2 expression levels were evaluated and correlated to platinum (CDDP) resistance.
24968707	overexpression	Hepatocellular Carcinoma	In the present study, ATF2 exhibited a higher expression level in the nucleus in tumoral tissues of HCC as detected by immunohistochemistry.
24289970	overexpression	Spindle Cell Sarcoma	High nuclear ATF2 expression was mainly observed in translocation-associated and/or spindle cell sarcomas including synovial sarcoma, desmoplastic small round cell tumor, endometrial stromal sarcoma, gastrointestinal stromal tumor, malignant peripheral nerve sheath tumor, and solitary fibrous tumor.
23416976	overexpression	B-Cell Non-Hodgkin Lymphoma	In samples of human B-cell lymphomas as well as Eμ-Myc-driven mouse B-cell lymphomas, we find that ATF2 as well as MAP kinase c-Jun N-terminal kinase (JNK) are significantly up-regulated compared with normal human B-cell lines and mouse B cells, respectively.
18700251	aberrant expression	Lobular Hemangioma	P-ATF2 was expressed in 13 out of 14 CAS and in all of 19 PG.
17786276	overexpression	Chronic Lymphocytic Leukemia	Significance analysis of microarray (SAM) identified 27 differentially expressed genes between these two subgroups with significant overexpression of ATF5 and underexpression of CDC16, PCDH8, SLAM, MNDA and ATF2 in CLL patients with poor outcome.
15185015	overexpression	Burkitt Lymphoma	Next, we showed by immunohistochemistry that the activated form of ATF2 (ATF-2pp) was highly expressed in six different BL samples.
28337266	altered expression	Prostate Carcinoma	Long non-coding RNA UCA1 promotes cell progression by acting as a competing endogenous RNA of ATF2 in prostate cancer. UCA1 directly interacted with miR-204 and decreased the binding of miR-204 to ATF2 3'UTR, which suppressed the degradation of ATF2 mRNA by miR-204.
28318081	Overexpression	Pancreatic Carcinoma	The results of our study showed that the ATF2 level in the pancreatic cancer tissues was higher than that in the adjacent non-tumorous tissues.

Summary
Symbol	ATF2
Name	activating transcription factor 2
Aliases	TREB7; CRE-BP1; HB16; cAMP responsive element binding protein 2; activating transcription factor 2 splice va ......
Location	2q31.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Somatic copy number alteration in primary tomur tissue

> The Cancer Genome Atlas (TCGA)

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Correlation between expression and SCNA as well as percentage of patients in different status.

Cancer	Full Name	# Sample	R	P	% Loss	% Neutral	% Gain	Status
BLCA	Bladder urothelial carcinoma	404	0.276	1.74e-08	25.7	60.1	14.1	Neutral
BRCA	Breast invasive carcinoma	1075	0.211	2.91e-12	21.8	69.5	8.7	Neutral
CESC	Cervical and endocervical cancers	292	0.316	3.51e-08	14.4	71.9	13.7	Neutral
COAD	Colon adenocarcinoma	449	0.294	2e-10	3.1	78.6	18.3	Neutral
ESCA	Esophageal carcinoma	183	0.468	2.46e-11	10.9	56.8	32.2	Neutral
GBM	Glioblastoma multiforme	147	0.173	0.0363	6.1	87.8	6.1	Neutral
HNSC	Head and Neck squamous cell carcinoma	514	0.379	4.97e-19	8.9	69.6	21.4	Neutral
KIRC	Kidney renal clear cell carcinoma	525	0.219	4.01e-07	2.9	81.5	15.6	Neutral
KIRP	Kidney renal papillary cell carcinoma	288	0.168	0.0043	1.4	80.2	18.4	Neutral
LAML	Acute Myeloid Leukemia	166	0.163	0.036	0	100	0	Neutral
LGG	Brain Lower Grade Glioma	513	0.015	0.726	4.9	93	2.1	Neutral
LIHC	Liver hepatocellular carcinoma	364	0.186	0.000368	11.3	74.7	14	Neutral
LUAD	Lung adenocarcinoma	512	0.33	1.91e-14	5.7	64.3	30.1	Neutral
LUSC	Lung squamous cell carcinoma	498	0.411	1e-21	9	58.6	32.3	Neutral
OV	Ovarian serous cystadenocarcinoma	300	0.543	2.12e-24	9	48.7	42.3	Gain
PAAD	Pancreatic adenocarcinoma	177	0.167	0.026	2.8	84.7	12.4	Neutral
PCPG	Pheochromocytoma and Paraganglioma	162	0.14	0.0753	8	90.7	1.2	Neutral
PRAD	Prostate adenocarcinoma	491	0.184	4.29e-05	11.6	86.4	2	Neutral
READ	Rectum adenocarcinoma	164	0.317	3.5e-05	6.1	68.3	25.6	Neutral
SARC	Sarcoma	255	0.229	0.000222	29	60.4	10.6	Neutral
SKCM	Skin Cutaneous Melanoma	367	0.267	2.02e-07	15	65.4	19.6	Neutral
STAD	Stomach adenocarcinoma	413	0.262	6.63e-08	9.9	71.7	18.4	Neutral
TGCT	Testicular Germ Cell Tumors	150	0.281	0.000494	3.3	66	30.7	Neutral
THCA	Thyroid carcinoma	497	0.001	0.987	2	97.8	0.2	Neutral
THYM	Thymoma	119	0.13	0.16	2.5	97.5	0	Neutral
UCEC	Uterine Corpus Endometrial Carcinoma	537	0.159	0.000213	3.5	79.1	17.3	Neutral

Summary
Symbol	ATF2
Name	activating transcription factor 2
Aliases	TREB7; CRE-BP1; HB16; cAMP responsive element binding protein 2; activating transcription factor 2 splice va ......
Location	2q31.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Methylation level in the promoter region of CR

> Methylation level in the promoter region of CR

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Correlation between expression and methylation as well as differential methylation analysis.

Cancer	Full Name	R	P	# N	# T	Delta beta (T vs N)	P value (T vs N)	Status
BLCA	Bladder urothelial carcinoma	-0.105	0.0299	17	408	0.001	0.268	NS/NA
BRCA	Breast invasive carcinoma	-0.182	6.9e-08	83	785	0.005	0.365	NS/NA
CESC	Cervical and endocervical cancers	-0.094	0.0982	3	306	NA	NA	NS/NA
COAD	Colon adenocarcinoma	-0.019	0.735	19	297	-0.009	0.803	NS/NA
ESCA	Esophageal carcinoma	-0.021	0.768	9	185	NA	NA	NS/NA
GBM	Glioblastoma multiforme	0.054	0.669	1	64	NA	NA	NS/NA
HNSC	Head and Neck squamous cell carcinoma	-0.067	0.117	20	522	-0.021	9.34e-06	NS/NA
KIRC	Kidney renal clear cell carcinoma	-0.069	0.202	24	319	0.052	2.27e-06	NS/NA
KIRP	Kidney renal papillary cell carcinoma	-0.024	0.682	23	275	-0.004	0.221	NS/NA
LAML	Acute Myeloid Leukemia	-0.159	0.0384	0	170	NA	NA	NS/NA
LGG	Brain Lower Grade Glioma	0.016	0.705	0	530	NA	NA	NS/NA
LIHC	Liver hepatocellular carcinoma	-0.072	0.142	41	373	0.008	0.00829	NS/NA
LUAD	Lung adenocarcinoma	-0.068	0.136	21	456	0.01	0.657	NS/NA
LUSC	Lung squamous cell carcinoma	-0.12	0.02	8	370	NA	NA	NS/NA
OV	Ovarian serous cystadenocarcinoma	0.217	0.581	0	9	NA	NA	NS/NA
PAAD	Pancreatic adenocarcinoma	-0.082	0.267	4	179	NA	NA	NS/NA
PCPG	Pheochromocytoma and Paraganglioma	-0.233	0.00137	3	184	NA	NA	NS/NA
PRAD	Prostate adenocarcinoma	-0.044	0.307	35	498	-0.008	0.038	NS/NA
READ	Rectum adenocarcinoma	-0.019	0.849	2	99	NA	NA	NS/NA
SARC	Sarcoma	-0.118	0.0561	0	263	NA	NA	NS/NA
SKCM	Skin Cutaneous Melanoma	-0.041	0.372	1	471	NA	NA	NS/NA
STAD	Stomach adenocarcinoma	-0.153	0.00307	0	372	NA	NA	NS/NA
TGCT	Testicular Germ Cell Tumors	-0.109	0.177	0	156	NA	NA	NS/NA
THCA	Thyroid carcinoma	-0.057	0.18	50	509	0.004	0.269	NS/NA
THYM	Thymoma	-0.098	0.282	2	120	NA	NA	NS/NA
UCEC	Uterine Corpus Endometrial Carcinoma	-0.081	0.0793	34	431	0.012	0.065	NS/NA

Summary
Symbol	ATF2
Name	activating transcription factor 2
Aliases	TREB7; CRE-BP1; HB16; cAMP responsive element binding protein 2; activating transcription factor 2 splice va ......
Location	2q31.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Primary tumor tissue from TCGA > Normal tumor tissue from HPA

>The Cancer Genome Atlas (TCGA) [ TOP ]
There is no record.

> The Human Protein Atlas (HPA)

[ TOP ]

Tissue	Level	Level Name
Adrenal gland	3	High
Bone marrow	3	High
Breast	3	High
Bronchus	2	Medium
Caudate	2	Medium
Cerebellum	3	High
Cerebral cortex	3	High
Cervix, uterine	2	Medium
Colon	2	Medium
Duodenum	3	High
Endometrium	3	High
Epididymis	2	Medium
Esophagus	2	Medium
Fallopian tube	2	Medium
Gallbladder	2	Medium
Heart muscle	1	Low
Hippocampus	3	High
Kidney	2	Medium
Liver	2	Medium
Lung	2	Medium
Lymph node	2	Medium
Nasopharynx	2	Medium
Oral mucosa	1	Low
Ovary	2	Medium
Pancreas	3	High
Parathyroid gland	2	Medium
Placenta	3	High
Prostate	3	High
Rectum	3	High
Salivary gland	3	High
Seminal vesicle	2	Medium
Skeletal muscle	0	Not detected
Skin	2	Medium
Small intestine	2	Medium
Smooth muscle	2	Medium
Soft tissue	2	Medium
Spleen	2	Medium
Stomach	1	Low
Testis	2	Medium
Thyroid gland	3	High
Tonsil	2	Medium
Urinary bladder	2	Medium
Vagina	1	Low

Summary
Symbol	ATF2
Name	activating transcription factor 2
Aliases	TREB7; CRE-BP1; HB16; cAMP responsive element binding protein 2; activating transcription factor 2 splice va ......
Location	2q31.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Association between expresson and subtype > Overall survival analysis based on expression > Association between expresson and stage > Association between expresson and grade

> Subtype

[ TOP ]

Association between expresson and subtype.

Cancer	Full Name	# Patients	P Value (Kruskal-Wallis)	Association	Source
BLCA	Bladder urothelial carcinoma	128	0.225	NS	24476821
BRCA	Breast invasive carcinoma	521	0.00604	Significant	23000897
COAD	Colon adenocarcinoma	149	0.123	NS	22810696
GBM	Glioblastoma multiforme	157	0.913	NS	26824661
HNSC	Head and Neck squamous cell carcinoma	279	4.63e-05	Significant	25631445
KIRP	Kidney renal papillary cell carcinoma	161	0.000196	Significant	26536169
LGG	Brain Lower Grade Glioma	513	0.000545	Significant	26824661
LUAD	Lung adenocarcinoma	230	0.000782	Significant	25079552
LUSC	Lung squamous cell carcinoma	178	0.139	NS	22960745
OV	Ovarian serous cystadenocarcinoma	287	0.532	NS	21720365
PRAD	Prostate adenocarcinoma	333	0.0121	Significant	26544944
READ	Rectum adenocarcinoma	67	0.399	NS	22810696
SKCM	Skin Cutaneous Melanoma	315	0.0284	Significant	26091043
STAD	Stomach adenocarcinoma	277	0.392	NS	25079317
THCA	Thyroid carcinoma	391	0.0971	NS	25417114
UCEC	Uterine Corpus Endometrial Carcinoma	232	0.774	NS	23636398

> Overall survival

[ TOP ]

Overall survival analysis based on expression.

Cancer	Full Name	# Patients	Hazard Ratio	P Value (Log Rank Test)	Association
BLCA	Bladder urothelial carcinoma	405	1.303	0.237	NS
BRCA	Breast invasive carcinoma	1079	1.274	0.269	NS
CESC	Cervical and endocervical cancers	291	2.092	0.0402	Shorter
COAD	Colon adenocarcinoma	439	0.805	0.458	NS
ESCA	Esophageal carcinoma	184	0.747	0.376	NS
GBM	Glioblastoma multiforme	158	0.762	0.278	NS
HNSC	Head and Neck squamous cell carcinoma	518	0.899	0.571	NS
KIRC	Kidney renal clear cell carcinoma	531	0.357	1.92e-06	Longer
KIRP	Kidney renal papillary cell carcinoma	287	2.801	0.0145	Shorter
LAML	Acute Myeloid Leukemia	149	0.774	0.396	NS
LGG	Brain Lower Grade Glioma	511	0.72	0.202	NS
LIHC	Liver hepatocellular carcinoma	365	1.142	0.595	NS
LUAD	Lung adenocarcinoma	502	0.963	0.856	NS
LUSC	Lung squamous cell carcinoma	494	1.039	0.842	NS
OV	Ovarian serous cystadenocarcinoma	303	1.186	0.414	NS
PAAD	Pancreatic adenocarcinoma	177	1.81	0.0376	Shorter
PCPG	Pheochromocytoma and Paraganglioma	179	510918199.797	0.193	NS
PRAD	Prostate adenocarcinoma	497	2.383	0.39	NS
READ	Rectum adenocarcinoma	159	1.016	0.986	NS
SARC	Sarcoma	259	1.189	0.565	NS
SKCM	Skin Cutaneous Melanoma	459	0.655	0.0328	Longer
STAD	Stomach adenocarcinoma	388	1.039	0.865	NS
TGCT	Testicular Germ Cell Tumors	134	0	0.361	NS
THCA	Thyroid carcinoma	500	3.784	0.0707	NS
THYM	Thymoma	119	1.602	0.602	NS
UCEC	Uterine Corpus Endometrial Carcinoma	543	1.428	0.245	NS

> Stage

[ TOP ]

Association between expresson and stage.

Cancer	Full Name	# Patients	R Value (Spearman)	P Value (Spearman)	Association
BLCA	Bladder urothelial carcinoma	406	0.065	0.189	NS
BRCA	Breast invasive carcinoma	1071	-0.035	0.258	NS
CESC	Cervical and endocervical cancers	167	0.037	0.634	NS
COAD	Colon adenocarcinoma	445	-0.047	0.327	NS
ESCA	Esophageal carcinoma	162	-0.053	0.505	NS
HNSC	Head and Neck squamous cell carcinoma	448	0.027	0.57	NS
KIRC	Kidney renal clear cell carcinoma	531	-0.169	8.95e-05	Lower
KIRP	Kidney renal papillary cell carcinoma	260	0.164	0.00809	Higher
LIHC	Liver hepatocellular carcinoma	347	0.066	0.218	NS
LUAD	Lung adenocarcinoma	507	0.09	0.0431	Higher
LUSC	Lung squamous cell carcinoma	497	0.015	0.741	NS
OV	Ovarian serous cystadenocarcinoma	302	-0.148	0.00989	Lower
PAAD	Pancreatic adenocarcinoma	176	0.093	0.219	NS
READ	Rectum adenocarcinoma	156	0.051	0.527	NS
SKCM	Skin Cutaneous Melanoma	410	-0.007	0.892	NS
STAD	Stomach adenocarcinoma	392	0.067	0.184	NS
TGCT	Testicular Germ Cell Tumors	81	-0.197	0.0775	NS
THCA	Thyroid carcinoma	499	-0.065	0.147	NS
UCEC	Uterine Corpus Endometrial Carcinoma	501	0.029	0.514	NS

> Grade

[ TOP ]

Association between expresson and grade.

Cancer	Full Name	# Patients	R Value (Spearman)	P Value (Spearman)	Association
CESC	Cervical and endocervical cancers	272	-0.064	0.292	NS
HNSC	Head and Neck squamous cell carcinoma	498	0.106	0.0183	Higher
KIRC	Kidney renal clear cell carcinoma	525	-0.15	0.000576	Lower
LGG	Brain Lower Grade Glioma	514	-0.017	0.702	NS
LIHC	Liver hepatocellular carcinoma	366	-0.006	0.908	NS
OV	Ovarian serous cystadenocarcinoma	296	-0.111	0.0562	NS
PAAD	Pancreatic adenocarcinoma	176	0.026	0.733	NS
STAD	Stomach adenocarcinoma	406	-0.028	0.578	NS
UCEC	Uterine Corpus Endometrial Carcinoma	534	0.106	0.0142	Higher

Summary
Symbol	ATF2
Name	activating transcription factor 2
Aliases	TREB7; CRE-BP1; HB16; cAMP responsive element binding protein 2; activating transcription factor 2 splice va ......
Location	2q31.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Targets inferred by reverse engineering method > Targets identified by ChIP-seq data

> Targets inferred by reverse engineering method [ TOP ]

> Targets identified by ChIP-seq data [ TOP ]

Summary
Symbol	ATF2
Name	activating transcription factor 2
Aliases	TREB7; CRE-BP1; HB16; cAMP responsive element binding protein 2; activating transcription factor 2 splice va ......
Location	2q31.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Drugs from DrugBank database

> Drugs from DrugBank database

[ TOP ]

DrugBank ID	Name	Type	All Targets
DB00852	Pseudoephedrine	Small Molecule Drug

Summary
Symbol	ATF2
Name	activating transcription factor 2
Aliases	TREB7; CRE-BP1; HB16; cAMP responsive element binding protein 2; activating transcription factor 2 splice va ......
Location	2q31.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Protein-Protein Interaction Network > miRNA Regulatory Relationship > Interactions from Text Mining

> Protein-Protein Interaction Network [ TOP ]

> miRNA Regulatory Relationship [ TOP ]

> Interactions from Text Mining

[ TOP ]

PMID	Cancer	Hierarchy	Gene	Relation to CR	Evidence
27377902	Renal Cell Carcinoma	downstream	CCNB1; CCND1; SNAI1; VIM	regulation	Mechanistic studies revealed that the transcription of CyclinB1, CyclinD1, Snail and Vimentin was directly regulated by ATF2 in RCC cells.
26645581	Melanoma	downstream	FUK; fucose salvage pathway	negative regulation; regulation	PKCε-dependent phosphorylation of ATF2 promoted its transcriptional repression of the gene encoding fucokinase (FUK), which mediates the fucose salvage pathway and thus global cellular protein fucosylation.
24968707	Hepatocellular Carcinoma	upstream	miR-451	negative regulation	Further investigation of the molecular mechanisms identified activating transcription factor 2(ATF2) as a target of miR-451. miR-451 inhibited ATF2 expression by binding to the 3'UTR.
28337266	Prostate Carcinoma	upstream	UCA1	Positive regulation	In addition, we found that ATF2 was a direct target gene of UCA1. UCA1 directly interacted with miR-204 and decreased the binding of miR-204 to ATF2 3'UTR, which suppressed the degradation of ATF2 mRNA by miR-204.