CR2Cancer

Summary
Symbol	BAG6
Name	BCL2 associated athanogene 6
Aliases	G3; D6S52E; BAT3; HLA-B associated transcript 3; BAG-6; BAG family molecular chaperone regulator 6; HLA-B as ......
Location	6p21.33
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Domain, Function and Classification > Gene Ontology > KEGG and Reactome Pathway

> Domain, Function and Classification

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Domain

PF12057 Domain of unknown function (DUF3538)
PF00240 Ubiquitin family

Function

ATP-independent molecular chaperone preventing the aggregation of misfolded and hydrophobic patches-containing proteins (PubMed:21636303). Functions as part of a cytosolic protein quality control complex, the BAG6/BAT3 complex, which maintains these client proteins in a soluble state and participates to their proper delivery to the endoplasmic reticulum or alternatively can promote their sorting to the proteasome where they undergo degradation (PubMed:20516149, PubMed:21636303, PubMed:21743475, PubMed:28104892). The BAG6/BAT3 complex is involved in the post-translational delivery of tail-anchored/type II transmembrane proteins to the endoplasmic reticulum membrane. Recruited to ribosomes, it interacts with the transmembrane region of newly synthesized tail-anchored proteins and together with SGTA and ASNA1 mediates their delivery to the endoplasmic reticulum (PubMed:20516149, PubMed:20676083, PubMed:28104892). Client proteins that cannot be properly delivered to the endoplasmic reticulum are ubiquitinated by RNF126, an E3 ubiquitin-protein ligase associated with BAG6 and are sorted to the proteasome (PubMed:24981174, PubMed:28104892, PubMed:27193484). SGTA which prevents the recruitment of RNF126 to BAG6 may negatively regulate the ubiquitination and the proteasomal degradation of client proteins (PubMed:23129660, PubMed:25179605, PubMed:27193484). Similarly, the BAG6/BAT3 complex also functions as a sorting platform for proteins of the secretory pathway that are mislocalized to the cytosol either delivering them to the proteasome for degradation or to the endoplasmic reticulum (PubMed:21743475). The BAG6/BAT3 complex also plays a role in the endoplasmic reticulum-associated degradation (ERAD), a quality control mechanism that eliminates unwanted proteins of the endoplasmic reticulum through their retrotranslocation to the cytosol and their targeting to the proteasome. It maintains these retrotranslocated proteins in an unfolded yet soluble state condition in the cytosol to ensure their proper delivery to the proteasome (PubMed:21636303). BAG6 is also required for selective ubiquitin-mediated degradation of defective nascent chain polypeptides by the proteasome. In this context, it may participate to the production of antigenic peptides and play a role in antigen presentation in immune response (By similarity). BAG6 is also involved in endoplasmic reticulum stress-induced pre-emptive quality control, a mechanism that selectively attenuates the translocation of newly synthesized proteins into the endoplasmic reticulum and reroutes them to the cytosol for proteasomal degradation. BAG6 may ensure the proper degradation of these proteins and thereby protects the endoplasmic reticulum from protein overload upon stress (PubMed:26565908). By inhibiting the polyubiquitination and subsequent proteasomal degradation of HSPA2 it may also play a role in the assembly of the synaptonemal complex during spermatogenesis (By similarity). Also positively regulates apoptosis by interacting with and stabilizing the proapoptotic factor AIFM1 (By similarity). ; FUNCTION: Involved in DNA damage-induced apoptosis: following DNA damage, accumulates in the nucleus and forms a complex with p300/EP300, enhancing p300/EP300-mediated p53/TP53 acetylation leading to increase p53/TP53 transcriptional activity (PubMed:17403783). When nuclear, may also act as a component of some chromatin regulator complex that regulates histone 3 'Lys-4' dimethylation (H3K4me2) (PubMed:18765639). ; FUNCTION: Released extracellularly via exosomes, it is a ligand of the natural killer/NK cells receptor NCR3 and stimulates NK cells cytotoxicity. It may thereby trigger NK cells cytotoxicity against neighboring tumor cells and immature myeloid dendritic cells (DC). ; FUNCTION: Mediates ricin-induced apoptosis.

Classification

Class	Modification	Substrate	Product	PubMed
#	#	#	#	#

> Gene Ontology [ TOP ]
Biological Process	GO:0001655 urogenital system development GO:0001822 kidney development GO:0006473 protein acetylation GO:0006475 internal protein amino acid acetylation GO:0007029 endoplasmic reticulum organization GO:0007059 chromosome segregation GO:0007126 meiotic nuclear division GO:0007127 meiosis I GO:0007129 synapsis GO:0007130 synaptonemal complex assembly GO:0007283 spermatogenesis GO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage GO:0009894 regulation of catabolic process GO:0009895 negative regulation of catabolic process GO:0009896 positive regulation of catabolic process GO:0010498 proteasomal protein catabolic process GO:0018205 peptidyl-lysine modification GO:0018393 internal peptidyl-lysine acetylation GO:0018394 peptidyl-lysine acetylation GO:0030323 respiratory tube development GO:0030324 lung development GO:0031329 regulation of cellular catabolic process GO:0031330 negative regulation of cellular catabolic process GO:0031647 regulation of protein stability GO:0032434 regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0032435 negative regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0034976 response to endoplasmic reticulum stress GO:0036503 ERAD pathway GO:0036506 maintenance of unfolded protein GO:0042176 regulation of protein catabolic process GO:0042177 negative regulation of protein catabolic process GO:0042771 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process GO:0043543 protein acylation GO:0045048 protein insertion into ER membrane GO:0045132 meiotic chromosome segregation GO:0045143 homologous chromosome segregation GO:0045732 positive regulation of protein catabolic process GO:0045861 negative regulation of proteolysis GO:0048232 male gamete generation GO:0050821 protein stabilization GO:0051205 protein insertion into membrane GO:0051321 meiotic cell cycle GO:0060541 respiratory system development GO:0061136 regulation of proteasomal protein catabolic process GO:0070059 intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress GO:0070192 chromosome organization involved in meiotic cell cycle GO:0070193 synaptonemal complex organization GO:0071816 tail-anchored membrane protein insertion into ER membrane GO:0072001 renal system development GO:0072331 signal transduction by p53 class mediator GO:0072332 intrinsic apoptotic signaling pathway by p53 class mediator GO:0072657 protein localization to membrane GO:0090150 establishment of protein localization to membrane GO:0097193 intrinsic apoptotic signaling pathway GO:0098813 nuclear chromosome segregation GO:1901799 negative regulation of proteasomal protein catabolic process GO:1903046 meiotic cell cycle process GO:1903050 regulation of proteolysis involved in cellular protein catabolic process GO:1903051 negative regulation of proteolysis involved in cellular protein catabolic process GO:1903362 regulation of cellular protein catabolic process GO:1903363 negative regulation of cellular protein catabolic process GO:1904292 regulation of ERAD pathway GO:1904294 positive regulation of ERAD pathway GO:1904327 protein localization to cytosolic proteasome complex GO:1904378 maintenance of unfolded protein involved in ERAD pathway GO:1904379 protein localization to cytosolic proteasome complex involved in ERAD pathway
Molecular Function	GO:0002020 protease binding GO:0030544 Hsp70 protein binding GO:0031072 heat shock protein binding GO:0031593 polyubiquitin binding GO:0031625 ubiquitin protein ligase binding GO:0032182 ubiquitin-like protein binding GO:0043021 ribonucleoprotein complex binding GO:0043022 ribosome binding GO:0043130 ubiquitin binding GO:0044389 ubiquitin-like protein ligase binding GO:0051787 misfolded protein binding GO:0070628 proteasome binding GO:1990381 ubiquitin-specific protease binding
Cellular Component	GO:0044445 cytosolic part GO:0071818 BAT3 complex GO:0072379 ER membrane insertion complex

> KEGG and Reactome Pathway [ TOP ]
KEGG	-
Reactome	-

Summary
Symbol	BAG6
Name	BCL2 associated athanogene 6
Aliases	G3; D6S52E; BAT3; HLA-B associated transcript 3; BAG-6; BAG family molecular chaperone regulator 6; HLA-B as ......
Location	6p21.33
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Mutation landscape in primary tumor tissue from TCGA > Mutation landscape in cancer cell line from CCLE > All mutations from COSMIC database V81 > Variations from text mining

> The Cancer Genome Atlas (TCGA) [ TOP ]

> Cancer Cell Line Encyclopedia (CCLE) [ TOP ]

> Catalogue of Somatic Mutations in Cancer (COSMIC)

[ TOP ]

COSMIC ID	CDS change	AA change	Mutation Type	Anatomical Site
COSM5915492	c.1282C>T	p.P428S	Substitution - Missense	Skin
COSM1443308	c.2824delC	p.Q942fs*85	Deletion - Frameshift	Large_intestine
COSM381580	c.1570G>T	p.G524C	Substitution - Missense	Lung
COSM3715468	c.1777C>T	p.Q593*	Substitution - Nonsense	Upper_aerodigestive_tract
COSM5566353	c.1499G>A	p.R500Q	Substitution - Missense	Prostate
COSM222095	c.469C>T	p.P157S	Substitution - Missense	Skin
COSM3396780	c.325C>G	p.H109D	Substitution - Missense	Breast
COSM4636131	c.3129G>A	p.K1043K	Substitution - coding silent	Large_intestine
COSM4665022	c.2176C>T	p.R726C	Substitution - Missense	Large_intestine
COSM3684217	c.194T>G	p.V65G	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM3774230	c.1855T>C	p.S619P	Substitution - Missense	Soft_tissue
COSM741904	c.2299G>T	p.G767W	Substitution - Missense	Lung
COSM5756831	c.1482C>T	p.T494T	Substitution - coding silent	Large_intestine
COSM5679797	c.1959A>C	p.P653P	Substitution - coding silent	Soft_tissue
COSM4986451	c.724C>T	p.P242S	Substitution - Missense	Soft_tissue
COSM3253756	c.594G>A	p.P198P	Substitution - coding silent	Stomach
COSM4153251	c.1354C>G	p.H452D	Substitution - Missense	Ovary
COSM3394088	c.2090C>T	p.S697L	Substitution - Missense	Pancreas
COSM3624661	c.343C>T	p.P115S	Substitution - Missense	Skin
COSM5809421	c.1631T>C	p.M544T	Substitution - Missense	Liver
COSM3774230	c.1855T>C	p.S619P	Substitution - Missense	Soft_tissue
COSM421405	c.2418C>T	p.I806I	Substitution - coding silent	Urinary_tract
COSM3784511	c.3332G>C	p.S1111T	Substitution - Missense	Pancreas
COSM1077622	c.2034C>T	p.G678G	Substitution - coding silent	Endometrium
COSM3624655	c.1340C>T	p.P447L	Substitution - Missense	Skin
COSM4003939	c.500T>G	p.V167G	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM309432	c.344delC	p.P115fs*53	Deletion - Frameshift	Large_intestine
COSM3253738	c.844A>T	p.S282C	Substitution - Missense	Central_nervous_system
COSM5357292	c.2966G>A	p.G989D	Substitution - Missense	Large_intestine
COSM4003939	c.500T>G	p.V167G	Substitution - Missense	Oesophagus
COSM5996480	c.305C>T	p.T102M	Substitution - Missense	Prostate
COSM4665043	c.275C>G	p.T92S	Substitution - Missense	Large_intestine
COSM1496295	c.751G>A	p.A251T	Substitution - Missense	Kidney
COSM483865	c.1520G>T	p.R507L	Substitution - Missense	Kidney
COSM3396780	c.325C>G	p.H109D	Substitution - Missense	Breast
COSM3253701	c.1590G>A	p.S530S	Substitution - coding silent	Large_intestine
COSM5951077	c.172C>T	p.R58W	Substitution - Missense	Oesophagus
COSM5447700	c.379C>T	p.R127W	Substitution - Missense	Large_intestine
COSM5014578	c.797C>G	p.S266C	Substitution - Missense	Kidney
COSM1077623	c.1886C>T	p.A629V	Substitution - Missense	Endometrium
COSM4665034	c.1287G>A	p.P429P	Substitution - coding silent	Large_intestine
COSM4449419	c.2228-1G>A	p.?	Unknown	Skin
COSM1496296	c.1161G>C	p.R387R	Substitution - coding silent	Kidney
COSM1077621	c.3084G>A	p.P1028P	Substitution - coding silent	Endometrium
COSM137451	c.1225C>T	p.P409S	Substitution - Missense	Skin
COSM4665036	c.1039C>T	p.R347*	Substitution - Nonsense	Large_intestine
COSM3394086	c.3061C>A	p.Q1021K	Substitution - Missense	Pancreas
COSM3774230	c.1855T>C	p.S619P	Substitution - Missense	Soft_tissue
COSM5996480	c.305C>T	p.T102M	Substitution - Missense	Prostate
COSM1077625	c.111G>T	p.M37I	Substitution - Missense	Endometrium
COSM1443309	c.1953T>C	p.P651P	Substitution - coding silent	Prostate
COSM5758919	c.868C>T	p.R290C	Substitution - Missense	Bone
COSM1443308	c.2824delC	p.Q942fs*85	Deletion - Frameshift	Large_intestine
COSM3715468	c.1777C>T	p.Q593*	Substitution - Nonsense	Upper_aerodigestive_tract
COSM3774230	c.1855T>C	p.S619P	Substitution - Missense	Soft_tissue
COSM3624661	c.343C>T	p.P115S	Substitution - Missense	Skin
COSM3624657	c.1218C>T	p.S406S	Substitution - coding silent	Large_intestine
COSM4459458	c.1108C>T	p.P370S	Substitution - Missense	Skin
COSM4848419	c.3289C>T	p.R1097W	Substitution - Missense	Cervix
COSM3774230	c.1855T>C	p.S619P	Substitution - Missense	Soft_tissue
COSM309433	c.588G>T	p.P196P	Substitution - coding silent	Lung
COSM4531009	c.174G>A	p.R58R	Substitution - coding silent	Skin
COSM4918204	c.1998G>T	p.Q666H	Substitution - Missense	Liver
COSM421404	c.399C>T	p.V133V	Substitution - coding silent	Urinary_tract
COSM345827	c.1589C>T	p.S530L	Substitution - Missense	Lung
COSM3662384	c.2871T>G	p.A957A	Substitution - coding silent	Liver
COSM3253685	c.2100G>T	p.Q700H	Substitution - Missense	Large_intestine
COSM218875	c.1250C>T	p.S417L	Substitution - Missense	Pancreas
COSM4665028	c.1521G>A	p.R507R	Substitution - coding silent	Large_intestine
COSM3994836	c.1371T>A	p.D457E	Substitution - Missense	Kidney
COSM3624653	c.1468C>T	p.P490S	Substitution - Missense	Skin
COSM3624637	c.3308G>A	p.R1103Q	Substitution - Missense	Skin
COSM3861748	c.1448-1G>T	p.?	Unknown	Stomach
COSM309431	c.595C>T	p.Q199*	Substitution - Nonsense	Soft_tissue
COSM5455478	c.505G>A	p.A169T	Substitution - Missense	Large_intestine
COSM32743	c.3381+3C>G	p.?	Unknown	Breast
COSM4654083	c.476A>C	p.Q159P	Substitution - Missense	Large_intestine
COSM1659926	c.2241C>G	p.A747A	Substitution - coding silent	Kidney
COSM1443308	c.2824delC	p.Q942fs*85	Deletion - Frameshift	Large_intestine
COSM5808494	c.117A>G	p.V39V	Substitution - coding silent	Liver
COSM1621429	c.1169delC	p.P390fs*61	Deletion - Frameshift	Liver
COSM3624655	c.1340C>T	p.P447L	Substitution - Missense	Skin
COSM3774230	c.1855T>C	p.S619P	Substitution - Missense	Kidney
COSM5759206	c.2441G>A	p.R814Q	Substitution - Missense	Bone
COSM1443313	c.103delG	p.A35fs*3	Deletion - Frameshift	Large_intestine
COSM4187949	c.3179C>A	p.A1060D	Substitution - Missense	Kidney
COSM3253764	c.431G>A	p.G144D	Substitution - Missense	Large_intestine
COSM5357292	c.2966G>A	p.G989D	Substitution - Missense	Large_intestine
COSM3774230	c.1855T>C	p.S619P	Substitution - Missense	Soft_tissue
COSM4006353	c.2447G>A	p.S816N	Substitution - Missense	Urinary_tract
COSM3624645	c.2251C>T	p.L751F	Substitution - Missense	Skin
COSM4933806	c.2044C>T	p.P682S	Substitution - Missense	Liver
COSM3624659	c.593C>T	p.P198L	Substitution - Missense	Skin
COSM5806677	c.355G>T	p.G119W	Substitution - Missense	Liver
COSM5996480	c.305C>T	p.T102M	Substitution - Missense	Prostate
COSM3394084	c.3364T>A	p.F1122I	Substitution - Missense	Pancreas
COSM3253728	c.1109C>A	p.P370H	Substitution - Missense	Large_intestine
COSM3624651	c.1586C>A	p.A529D	Substitution - Missense	Skin
COSM4665018	c.2424G>A	p.G808G	Substitution - coding silent	Large_intestine
COSM4665038	c.477+1G>A	p.?	Unknown	Large_intestine
COSM3928333	c.1239T>G	p.N413K	Substitution - Missense	Central_nervous_system
COSM1600279	c.103G>A	p.A35T	Substitution - Missense	Stomach
COSM3774230	c.1855T>C	p.S619P	Substitution - Missense	Soft_tissue
COSM3697749	c.3105C>A	p.A1035A	Substitution - coding silent	Large_intestine
COSM3774230	c.1855T>C	p.S619P	Substitution - Missense	Soft_tissue
COSM3774230	c.1855T>C	p.S619P	Substitution - Missense	Soft_tissue
COSM3948983	c.2274G>T	p.M758I	Substitution - Missense	Lung
COSM3861746	c.1539G>C	p.G513G	Substitution - coding silent	Stomach
COSM4405049	c.1208A>G	p.Q403R	Substitution - Missense	Skin
COSM5946334	c.1936-13_1936-10delCTTT	p.?	Unknown	Haematopoietic_and_lymphoid_tissue
COSM4924499	c.2979A>G	p.E993E	Substitution - coding silent	Liver
COSM5996480	c.305C>T	p.T102M	Substitution - Missense	Prostate
COSM4665026	c.1533T>G	p.P511P	Substitution - coding silent	Large_intestine
COSM5710058	c.146C>T	p.S49F	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM3774230	c.1855T>C	p.S619P	Substitution - Missense	Kidney
COSM4665040	c.459G>A	p.M153I	Substitution - Missense	Large_intestine
COSM3861752	c.821T>C	p.L274P	Substitution - Missense	Stomach
COSM5996480	c.305C>T	p.T102M	Substitution - Missense	Prostate
COSM4665015	c.2910T>C	p.P970P	Substitution - coding silent	Large_intestine
COSM1077624	c.1521G>T	p.R507R	Substitution - coding silent	Endometrium
COSM3765263	c.173G>A	p.R58Q	Substitution - Missense	Central_nervous_system
COSM3624657	c.1218C>T	p.S406S	Substitution - coding silent	Large_intestine
COSM3861744	c.2185G>A	p.G729R	Substitution - Missense	Stomach
COSM134119	c.421C>T	p.P141S	Substitution - Missense	Skin
COSM5676254	c.1193C>T	p.P398L	Substitution - Missense	Soft_tissue
COSM3253754	c.614C>T	p.P205L	Substitution - Missense	Large_intestine
COSM3253669	c.2460G>A	p.V820V	Substitution - coding silent	Large_intestine
COSM309432	c.344delC	p.P115fs*53	Deletion - Frameshift	Large_intestine
COSM3253647	c.2887C>T	p.R963W	Substitution - Missense	Large_intestine
COSM82018	c.903G>A	p.T301T	Substitution - coding silent	Ovary
COSM3253675	c.2234T>C	p.F745S	Substitution - Missense	Large_intestine
COSM5510140	c.1179T>C	p.N393N	Substitution - coding silent	Biliary_tract
COSM1723860	c.2222_2223CC>TT	p.A741V	Substitution - Missense	Skin
COSM5640465	c.307G>A	p.G103R	Substitution - Missense	Oesophagus
COSM5768892	c.922G>T	p.E308*	Substitution - Nonsense	Breast
COSM396195	c.929G>T	p.R310L	Substitution - Missense	Lung
COSM218876	c.268C>T	p.P90S	Substitution - Missense	Pancreas
COSM1621431	c.1007A>T	p.D336V	Substitution - Missense	Liver
COSM5762532	c.1126G>A	p.G376R	Substitution - Missense	Pancreas
COSM3624657	c.1218C>T	p.S406S	Substitution - coding silent	Skin
COSM5771052	c.2405C>G	p.T802S	Substitution - Missense	Breast
COSM5996480	c.305C>T	p.T102M	Substitution - Missense	Prostate
COSM3624639	c.3072G>A	p.R1024R	Substitution - coding silent	Skin
COSM5996480	c.305C>T	p.T102M	Substitution - Missense	Prostate
COSM4460894	c.1165C>T	p.P389S	Substitution - Missense	Skin
COSM3624663	c.296C>A	p.S99Y	Substitution - Missense	Skin
COSM3624647	c.2024C>T	p.P675L	Substitution - Missense	Skin
COSM218875	c.1250C>T	p.S417L	Substitution - Missense	Pancreas
COSM5756831	c.1482C>T	p.T494T	Substitution - coding silent	Large_intestine
COSM1487604	c.1454A>G	p.Q485R	Substitution - Missense	Breast
COSM4940833	c.1658C>T	p.T553I	Substitution - Missense	Liver
COSM309431	c.595C>T	p.Q199*	Substitution - Nonsense	Lung
COSM1723860	c.2222_2223CC>TT	p.A741V	Substitution - Missense	Skin
COSM309433	c.588G>T	p.P196P	Substitution - coding silent	Soft_tissue
COSM5790833	c.1370-1G>C	p.?	Unknown	Breast
COSM5988196	c.3308G>C	p.R1103P	Substitution - Missense	Salivary_gland
COSM134119	c.421C>T	p.P141S	Substitution - Missense	Skin
COSM5806677	c.355G>T	p.G119W	Substitution - Missense	Liver
COSM741905	c.2635G>T	p.G879W	Substitution - Missense	Lung
COSM4423264	c.1415C>A	p.P472H	Substitution - Missense	Central_nervous_system
COSM4665030	c.1398G>A	p.P466P	Substitution - coding silent	Large_intestine
COSM3662384	c.2871T>G	p.A957A	Substitution - coding silent	Liver
COSM4160842	c.1569C>T	p.A523A	Substitution - coding silent	Thyroid
COSM3624643	c.2338C>T	p.R780*	Substitution - Nonsense	Skin
COSM3830112	c.3006A>G	p.E1002E	Substitution - coding silent	Breast
COSM4401171	c.3114T>C	p.S1038S	Substitution - coding silent	Skin
COSM1621429	c.1169delC	p.P390fs*61	Deletion - Frameshift	Large_intestine
COSM279118	c.2642A>G	p.Q881R	Substitution - Missense	Large_intestine
COSM218876	c.268C>T	p.P90S	Substitution - Missense	Pancreas
COSM5423833	c.2720G>C	p.W907S	Substitution - Missense	Prostate
COSM5457252	c.3190G>A	p.A1064T	Substitution - Missense	Large_intestine
COSM3861740	c.3009T>G	p.P1003P	Substitution - coding silent	Stomach
COSM4565660	c.2349_2350CC>TT	p.H784Y	Substitution - Missense	Skin
COSM3774230	c.1855T>C	p.S619P	Substitution - Missense	Soft_tissue
COSM3861742	c.2618T>C	p.L873P	Substitution - Missense	Stomach
COSM4155170	c.1891C>A	p.P631T	Substitution - Missense	Kidney
COSM4665032	c.1342G>A	p.V448M	Substitution - Missense	Large_intestine
COSM4936826	c.2994A>T	p.S998S	Substitution - coding silent	Liver
COSM4832665	c.2114C>T	p.S705F	Substitution - Missense	Cervix
COSM3624641	c.2787C>T	p.A929A	Substitution - coding silent	Skin
COSM5357147	c.904G>A	p.D302N	Substitution - Missense	Large_intestine
COSM4564844	c.1481_1482CC>TT	p.T494I	Substitution - Missense	Skin
COSM1443312	c.756C>T	p.G252G	Substitution - coding silent	Large_intestine
COSM5898292	c.2228-5C>T	p.?	Unknown	Skin
COSM309432	c.344delC	p.P115fs*53	Deletion - Frameshift	Lung
COSM1443310	c.1243G>A	p.E415K	Substitution - Missense	Large_intestine
COSM3253647	c.2887C>T	p.R963W	Substitution - Missense	Large_intestine
COSM1600279	c.103G>A	p.A35T	Substitution - Missense	Central_nervous_system
COSM1077620	c.3242G>A	p.R1081Q	Substitution - Missense	Endometrium
COSM1443311	c.1169_1170insC	p.T391fs*29	Insertion - Frameshift	Large_intestine
COSM353435	c.903G>T	p.T301T	Substitution - coding silent	Lung
COSM118124	c.3204C>T	p.A1068A	Substitution - coding silent	Ovary
COSM3394090	c.1296C>T	p.T432T	Substitution - coding silent	Pancreas
COSM1443307	c.2845A>G	p.M949V	Substitution - Missense	Large_intestine
COSM3624649	c.1872C>G	p.P624P	Substitution - coding silent	Skin
COSM595959	c.1329G>A	p.Q443Q	Substitution - coding silent	Kidney
COSM4665020	c.2420C>T	p.T807M	Substitution - Missense	Large_intestine
COSM1245988	c.553-10C>T	p.?	Unknown	Oesophagus
COSM4614229	c.344_345insC	p.G116fs*11	Insertion - Frameshift	Large_intestine
COSM3861750	c.1203T>A	p.P401P	Substitution - coding silent	Stomach
COSM4665024	c.2156G>T	p.S719I	Substitution - Missense	Large_intestine
COSM5962807	c.1741G>A	p.A581T	Substitution - Missense	Breast
COSM5835180	c.2127_2128insT	p.L710fs*9	Insertion - Frameshift	Breast
COSM3774230	c.1855T>C	p.S619P	Substitution - Missense	Soft_tissue
COSM5996480	c.305C>T	p.T102M	Substitution - Missense	Prostate
COSM3774230	c.1855T>C	p.S619P	Substitution - Missense	Soft_tissue
COSM5447891	c.813C>T	p.V271V	Substitution - coding silent	Large_intestine
COSM3774230	c.1855T>C	p.S619P	Substitution - Missense	Soft_tissue
COSM1621431	c.1007A>T	p.D336V	Substitution - Missense	Liver
COSM3674656	c.893C>T	p.A298V	Substitution - Missense	Prostate
COSM4970184	c.987C>T	p.N329N	Substitution - coding silent	Central_nervous_system
COSM741906	c.3229G>A	p.E1077K	Substitution - Missense	Lung
COSM1077623	c.1886C>T	p.A629V	Substitution - Missense	Endometrium
COSM1600279	c.103G>A	p.A35T	Substitution - Missense	Central_nervous_system
COSM1665365	c.779delA	p.N260fs*57	Deletion - Frameshift	Kidney
COSM5014580	c.139G>C	p.A47P	Substitution - Missense	Kidney
COSM4153251	c.1354C>G	p.H452D	Substitution - Missense	Ovary
COSM5345134	c.674G>A	p.R225Q	Substitution - Missense	Large_intestine

> Text Mining based Variations

[ TOP ]

PMID	Variation	Cancer	Evidence
17086209	mutation (loss of function)	Colon Carcinoma	Bi-allelic inactivating mutations were found in the FXR1, SEC31L1, NCOR1, BAT3, PHF14, ZNF294, C19ORF5 genes as well as genes coding for proteins with yet unknown functions.
18978787	mutation	Lung Carcinoma	Pooling data with two other GWA studies (5,095 cases, 5,200 controls) and with replication in an additional 2,484 cases and 3,036 controls, we identified two newly associated risk loci mapping to 6p21.33 (rs3117582, BAT3-MSH5; P(combined) = 4.97 x 10(-10)) and 5p15.33 (rs401681, CLPTM1L; P(combined) = 7.90 x 10(-9)).

Summary
Symbol	BAG6
Name	BCL2 associated athanogene 6
Aliases	G3; D6S52E; BAT3; HLA-B associated transcript 3; BAG-6; BAG family molecular chaperone regulator 6; HLA-B as ......
Location	6p21.33
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Post-translational modification (PTM)

> Post-translational modification (PTM)

[ TOP ]

Filter By:

Uniprot ID	Position	Amino Acid	Description	Upstream Enzyme	Affected By Mutation	Amino Acid Sequence Variant
P46379	96	S	Phosphoserine	-	No	None detected
P46379	113	S	Phosphoserine	-	No	None detected
P46379	117	T	Phosphothreonine	-	No	None detected
P46379	350	T	Phosphothreonine	-	No	None detected
P46379	964	S	Phosphoserine	-	No	None detected
P46379	973	S	Phosphoserine	-	No	None detected
P46379	1053	T	Phosphothreonine	-	No	None detected
P46379	1081	S	Phosphoserine	-	No	None detected
P46379	1117	S	Phosphoserine	-	No	None detected

Summary
Symbol	BAG6
Name	BCL2 associated athanogene 6
Aliases	G3; D6S52E; BAT3; HLA-B associated transcript 3; BAG-6; BAG family molecular chaperone regulator 6; HLA-B as ......
Location	6p21.33
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Expression analysis in primary tumor tissue from TCGA > Expression level in cancer cell line from CCLE > Expression level in human normal tissue from HPA > Text mining based expression change

> The Cancer Genome Atlas (TCGA)

[ TOP ]

Differential expression analysis for cancers with more than 10 normal samples

Cancer	Full Name	# N	# T	Median (N)	Median (T)	LogFC	Adj. P	Status
BLCA	Bladder urothelial carcinoma	19	408	7.787	8.06	0.26	0.0122	NS
BRCA	Breast invasive carcinoma	112	1100	7.512	7.809	0.327	3.64e-14	NS
CESC	Cervical and endocervical cancers	3	306	7.596	7.922	NA	NA	NA
COAD	Colon adenocarcinoma	41	459	8.109	7.931	-0.126	0.0622	NS
ESCA	Esophageal carcinoma	11	185	7.909	8.07	0.095	0.612	NS
GBM	Glioblastoma multiforme	5	166	7.86	7.715	NA	NA	NA
HNSC	Head and Neck squamous cell carcinoma	44	522	7.878	7.688	-0.218	0.000271	NS
KIRC	Kidney renal clear cell carcinoma	72	534	7.63	7.68	0.039	0.388	NS
KIRP	Kidney renal papillary cell carcinoma	32	291	7.928	8.066	0.116	0.0763	NS
LAML	Acute Myeloid Leukemia	0	173	NA	7.849	NA	NA	NA
LGG	Brain Lower Grade Glioma	0	530	NA	7.921	NA	NA	NA
LIHC	Liver hepatocellular carcinoma	50	373	7.419	7.773	0.388	1.64e-07	NS
LUAD	Lung adenocarcinoma	59	517	7.826	8.041	0.261	6.95e-05	NS
LUSC	Lung squamous cell carcinoma	51	501	7.843	7.821	0.027	0.717	NS
OV	Ovarian serous cystadenocarcinoma	0	307	NA	8.38	NA	NA	NA
PAAD	Pancreatic adenocarcinoma	4	179	7.678	7.587	NA	NA	NA
PCPG	Pheochromocytoma and Paraganglioma	3	184	8.331	7.877	NA	NA	NA
PRAD	Prostate adenocarcinoma	52	498	7.744	7.997	0.312	2.68e-14	NS
READ	Rectum adenocarcinoma	10	167	7.855	8.023	0.268	0.0512	NS
SARC	Sarcoma	2	263	7.747	7.82	NA	NA	NA
SKCM	Skin Cutaneous Melanoma	1	472	8.346	8.652	NA	NA	NA
STAD	Stomach adenocarcinoma	35	415	7.993	7.966	0.095	0.307	NS
TGCT	Testicular Germ Cell Tumors	0	156	NA	8.375	NA	NA	NA
THCA	Thyroid carcinoma	59	509	7.752	8.113	0.355	3.47e-25	NS
THYM	Thymoma	2	120	8.141	8.108	NA	NA	NA
UCEC	Uterine Corpus Endometrial Carcinoma	35	546	7.701	8.107	0.379	3.59e-08	NS

> Cancer Cell Line Encyclopedia (CCLE) [ TOP ]
There is no record.

> The Human Protein Atlas (HPA)

[ TOP ]

Tissue	Expression Level (TPM)
Adipose tissue	6.5
Adrenal gland	33.2
Appendix	15.1
Bone marrow	10.4
Breast	13.8
Cerebral cortex	13.9
Cervix, uterine	28.2
Colon	20.8
Duodenum	35.3
Endometrium	34.6
Epididymis	38.3
Esophagus	13.7
Fallopian tube	31.4
Gallbladder	13
Heart muscle	14.2
Kidney	13.4
Liver	11.2
Lung	33.5
Lymph node	17.1
Ovary	9.7
Pancreas	3.4
Parathyroid gland	6.8
Placenta	24
Prostate	26.9
Rectum	28.9
Salivary gland	3.6
Seminal vesicle	6.4
Skeletal muscle	17.7
Skin	22.9
Small intestine	31.5
Smooth muscle	19.4
Spleen	27.7
Stomach	21.6
Testis	135.8
Thyroid gland	26.8
Tonsil	23.1
Urinary bladder	11.1

> Text Mining based Expression

[ TOP ]

PMID	Expression	Cancer	Evidence
25918110	underexpression	Breast Carcinoma	The main subexpressed protein network included mitochondrial proteins involved in oxidative phosphorylation. We propose BAG6, DDX39, ANXA8 and COX4 as putative biomarkers in breast cancer.
28672194	Underexpression	Clear Cell Renal Carcinoma	Furthermore, down-regulation of ATP5A1, ATPAF1, ATP5G1/G2/G3 was confirmed on the protein level using Western Blot and immunohistochemistry. We observed that altered expression of ATPAF1 and ATP5G1/G2/G3 was correlated with overall survival in patients with ccRCC.

Summary
Symbol	BAG6
Name	BCL2 associated athanogene 6
Aliases	G3; D6S52E; BAT3; HLA-B associated transcript 3; BAG-6; BAG family molecular chaperone regulator 6; HLA-B as ......
Location	6p21.33
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Somatic copy number alteration in primary tomur tissue

> The Cancer Genome Atlas (TCGA)

[ TOP ]

Correlation between expression and SCNA as well as percentage of patients in different status.

Cancer	Full Name	# Sample	R	P	% Loss	% Neutral	% Gain	Status
BLCA	Bladder urothelial carcinoma	404	0.595	4.69e-40	19.1	54.2	26.7	Neutral
BRCA	Breast invasive carcinoma	1075	0.632	7.71e-121	14.1	60.7	25.1	Neutral
CESC	Cervical and endocervical cancers	292	0.785	2.79e-62	12	61.3	26.7	Neutral
COAD	Colon adenocarcinoma	449	0.481	2.33e-27	9.8	69.3	20.9	Neutral
ESCA	Esophageal carcinoma	183	0.599	3.24e-19	21.3	50.8	27.9	Neutral
GBM	Glioblastoma multiforme	147	0.471	1.68e-09	19	76.9	4.1	Neutral
HNSC	Head and Neck squamous cell carcinoma	514	0.646	4.1e-62	16	65.8	18.3	Neutral
KIRC	Kidney renal clear cell carcinoma	525	0.479	1.97e-31	18.7	79.4	1.9	Neutral
KIRP	Kidney renal papillary cell carcinoma	288	0.612	4.92e-31	9.7	88.9	1.4	Neutral
LAML	Acute Myeloid Leukemia	166	0.215	0.00532	0	100	0	Neutral
LGG	Brain Lower Grade Glioma	513	0.375	1.5e-18	5.7	92.2	2.1	Neutral
LIHC	Liver hepatocellular carcinoma	364	0.725	1.64e-60	2.5	56.9	40.7	Gain
LUAD	Lung adenocarcinoma	512	0.581	1.28e-47	11.5	51.2	37.3	Gain
LUSC	Lung squamous cell carcinoma	498	0.631	9.17e-57	24.5	51.4	24.1	Neutral
OV	Ovarian serous cystadenocarcinoma	300	0.715	2.82e-48	19.7	33	47.3	Gain
PAAD	Pancreatic adenocarcinoma	177	0.547	3.24e-15	31.1	61	7.9	Neutral
PCPG	Pheochromocytoma and Paraganglioma	162	0.323	2.69e-05	1.2	90.1	8.6	Neutral
PRAD	Prostate adenocarcinoma	491	0.164	0.000262	4.7	91.4	3.9	Neutral
READ	Rectum adenocarcinoma	164	0.574	9.12e-16	10.4	61.6	28	Neutral
SARC	Sarcoma	255	0.696	2.62e-38	26.7	51.4	22	Neutral
SKCM	Skin Cutaneous Melanoma	367	0.656	1.54e-46	8.4	40.1	51.5	Gain
STAD	Stomach adenocarcinoma	413	0.574	1.64e-37	11.9	64.2	24	Neutral
TGCT	Testicular Germ Cell Tumors	150	0.322	5.95e-05	10	71.3	18.7	Neutral
THCA	Thyroid carcinoma	497	0.148	0.000973	0.8	98.8	0.4	Neutral
THYM	Thymoma	119	0.684	9.67e-18	16.8	83.2	0	Neutral
UCEC	Uterine Corpus Endometrial Carcinoma	537	0.484	6.24e-33	2.6	78.4	19	Neutral

Summary
Symbol	BAG6
Name	BCL2 associated athanogene 6
Aliases	G3; D6S52E; BAT3; HLA-B associated transcript 3; BAG-6; BAG family molecular chaperone regulator 6; HLA-B as ......
Location	6p21.33
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Methylation level in the promoter region of CR

> Methylation level in the promoter region of CR

[ TOP ]

Correlation between expression and methylation as well as differential methylation analysis.

Cancer	Full Name	R	P	# N	# T	Delta beta (T vs N)	P value (T vs N)	Status
BLCA	Bladder urothelial carcinoma	-0.353	9.45e-14	17	408	-0.002	0.368	NS/NA
BRCA	Breast invasive carcinoma	-0.262	4.84e-15	83	785	-0.007	0.00748	NS/NA
CESC	Cervical and endocervical cancers	-0.433	0	3	306	NA	NA	NS/NA
COAD	Colon adenocarcinoma	-0.264	2.22e-06	19	297	0.02	0.000182	NS/NA
ESCA	Esophageal carcinoma	-0.472	2.38e-12	9	185	NA	NA	NS/NA
GBM	Glioblastoma multiforme	-0.354	0.00398	1	64	NA	NA	NS/NA
HNSC	Head and Neck squamous cell carcinoma	-0.268	2.88e-10	20	522	0.001	0.833	NS/NA
KIRC	Kidney renal clear cell carcinoma	-0.222	3.5e-05	24	319	0.007	0.000148	NS/NA
KIRP	Kidney renal papillary cell carcinoma	-0.178	0.00208	23	275	0.007	2.92e-05	NS/NA
LAML	Acute Myeloid Leukemia	-0.242	0.00153	0	170	NA	NA	NS/NA
LGG	Brain Lower Grade Glioma	-0.343	5.41e-16	0	530	NA	NA	NS/NA
LIHC	Liver hepatocellular carcinoma	-0.419	0	41	373	-0.18	1.25e-24	NS/NA
LUAD	Lung adenocarcinoma	-0.482	0	21	456	-0.108	1.07e-06	NS/NA
LUSC	Lung squamous cell carcinoma	-0.399	5.03e-17	8	370	NA	NA	NS/NA
OV	Ovarian serous cystadenocarcinoma	-0.817	0.0108	0	9	NA	NA	NS/NA
PAAD	Pancreatic adenocarcinoma	-0.224	0.00236	4	179	NA	NA	NS/NA
PCPG	Pheochromocytoma and Paraganglioma	-0.248	0.000639	3	184	NA	NA	NS/NA
PRAD	Prostate adenocarcinoma	-0.389	0	35	498	-0.004	8.87e-05	NS/NA
READ	Rectum adenocarcinoma	-0.376	0.000122	2	99	NA	NA	NS/NA
SARC	Sarcoma	-0.428	3.86e-13	0	263	NA	NA	NS/NA
SKCM	Skin Cutaneous Melanoma	-0.513	0	1	471	NA	NA	NS/NA
STAD	Stomach adenocarcinoma	-0.452	0	0	372	NA	NA	NS/NA
TGCT	Testicular Germ Cell Tumors	-0.297	0.000175	0	156	NA	NA	NS/NA
THCA	Thyroid carcinoma	-0.387	0	50	509	-0.073	5.94e-21	NS/NA
THYM	Thymoma	-0.406	4.3e-06	2	120	NA	NA	NS/NA
UCEC	Uterine Corpus Endometrial Carcinoma	-0.418	0	34	431	-0.003	0.142	NS/NA

Summary
Symbol	BAG6
Name	BCL2 associated athanogene 6
Aliases	G3; D6S52E; BAT3; HLA-B associated transcript 3; BAG-6; BAG family molecular chaperone regulator 6; HLA-B as ......
Location	6p21.33
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Primary tumor tissue from TCGA > Normal tumor tissue from HPA

>The Cancer Genome Atlas (TCGA) [ TOP ]
There is no record.

> The Human Protein Atlas (HPA)

[ TOP ]

Tissue	Level	Level Name
Adrenal gland	2	Medium
Appendix	2	Medium
Bone marrow	2	Medium
Breast	2	Medium
Bronchus	2	Medium
Caudate	2	Medium
Cerebellum	2	Medium
Cerebral cortex	2	Medium
Cervix, uterine	2	Medium
Colon	2	Medium
Duodenum	2	Medium
Endometrium	2	Medium
Epididymis	2	Medium
Esophagus	2	Medium
Fallopian tube	2	Medium
Gallbladder	2	Medium
Heart muscle	2	Medium
Hippocampus	2	Medium
Kidney	2	Medium
Liver	2	Medium
Lung	1	Low
Lymph node	2	Medium
Nasopharynx	2	Medium
Oral mucosa	1	Low
Ovary	2	Medium
Pancreas	2	Medium
Parathyroid gland	2	Medium
Placenta	2	Medium
Prostate	2	Medium
Rectum	2	Medium
Salivary gland	2	Medium
Seminal vesicle	1	Low
Skeletal muscle	1	Low
Skin	2	Medium
Small intestine	2	Medium
Smooth muscle	2	Medium
Soft tissue	1	Low
Spleen	1	Low
Stomach	2	Medium
Testis	3	High
Thyroid gland	2	Medium
Tonsil	2	Medium
Urinary bladder	2	Medium
Vagina	2	Medium

Summary
Symbol	BAG6
Name	BCL2 associated athanogene 6
Aliases	G3; D6S52E; BAT3; HLA-B associated transcript 3; BAG-6; BAG family molecular chaperone regulator 6; HLA-B as ......
Location	6p21.33
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Association between expresson and subtype > Overall survival analysis based on expression > Association between expresson and stage > Association between expresson and grade

> Subtype

[ TOP ]

Association between expresson and subtype.

Cancer	Full Name	# Patients	P Value (Kruskal-Wallis)	Association	Source
BLCA	Bladder urothelial carcinoma	128	0.0346	Significant	24476821
BRCA	Breast invasive carcinoma	521	6.48e-15	Significant	23000897
COAD	Colon adenocarcinoma	149	0.000247	Significant	22810696
GBM	Glioblastoma multiforme	157	0.000632	Significant	26824661
HNSC	Head and Neck squamous cell carcinoma	279	0.0106	Significant	25631445
KIRP	Kidney renal papillary cell carcinoma	161	0.459	NS	26536169
LGG	Brain Lower Grade Glioma	513	5.16e-22	Significant	26824661
LUAD	Lung adenocarcinoma	230	0.0326	Significant	25079552
LUSC	Lung squamous cell carcinoma	178	0.00449	Significant	22960745
OV	Ovarian serous cystadenocarcinoma	287	0.143	NS	21720365
PRAD	Prostate adenocarcinoma	333	1.54e-07	Significant	26544944
READ	Rectum adenocarcinoma	67	0.471	NS	22810696
SKCM	Skin Cutaneous Melanoma	315	0.00274	Significant	26091043
STAD	Stomach adenocarcinoma	277	2.8e-07	Significant	25079317
THCA	Thyroid carcinoma	391	1.1e-13	Significant	25417114
UCEC	Uterine Corpus Endometrial Carcinoma	232	2.23e-05	Significant	23636398

> Overall survival

[ TOP ]

Overall survival analysis based on expression.

Cancer	Full Name	# Patients	Hazard Ratio	P Value (Log Rank Test)	Association
BLCA	Bladder urothelial carcinoma	405	0.76	0.208	NS
BRCA	Breast invasive carcinoma	1079	1.12	0.621	NS
CESC	Cervical and endocervical cancers	291	1.642	0.121	NS
COAD	Colon adenocarcinoma	439	1.2	0.519	NS
ESCA	Esophageal carcinoma	184	0.885	0.738	NS
GBM	Glioblastoma multiforme	158	0.856	0.529	NS
HNSC	Head and Neck squamous cell carcinoma	518	1.048	0.803	NS
KIRC	Kidney renal clear cell carcinoma	531	0.922	0.71	NS
KIRP	Kidney renal papillary cell carcinoma	287	0.584	0.237	NS
LAML	Acute Myeloid Leukemia	149	1.341	0.306	NS
LGG	Brain Lower Grade Glioma	511	0.464	0.00195	Longer
LIHC	Liver hepatocellular carcinoma	365	1.108	0.69	NS
LUAD	Lung adenocarcinoma	502	0.952	0.819	NS
LUSC	Lung squamous cell carcinoma	494	0.935	0.738	NS
OV	Ovarian serous cystadenocarcinoma	303	0.838	0.395	NS
PAAD	Pancreatic adenocarcinoma	177	0.607	0.0993	NS
PCPG	Pheochromocytoma and Paraganglioma	179	0.295	0.262	NS
PRAD	Prostate adenocarcinoma	497	1.009	0.995	NS
READ	Rectum adenocarcinoma	159	0.288	0.1	NS
SARC	Sarcoma	259	2.402	0.0011	Shorter
SKCM	Skin Cutaneous Melanoma	459	1.327	0.125	NS
STAD	Stomach adenocarcinoma	388	0.857	0.477	NS
TGCT	Testicular Germ Cell Tumors	134	0	0.157	NS
THCA	Thyroid carcinoma	500	0.616	0.422	NS
THYM	Thymoma	119	0.15	0.0471	Longer
UCEC	Uterine Corpus Endometrial Carcinoma	543	1.844	0.05	Shorter

> Stage

[ TOP ]

Association between expresson and stage.

Cancer	Full Name	# Patients	R Value (Spearman)	P Value (Spearman)	Association
BLCA	Bladder urothelial carcinoma	406	-0.11	0.0273	Lower
BRCA	Breast invasive carcinoma	1071	0.073	0.0172	Higher
CESC	Cervical and endocervical cancers	167	0.078	0.317	NS
COAD	Colon adenocarcinoma	445	0.168	0.000369	Higher
ESCA	Esophageal carcinoma	162	-0.046	0.564	NS
HNSC	Head and Neck squamous cell carcinoma	448	-0.027	0.564	NS
KIRC	Kidney renal clear cell carcinoma	531	-0.049	0.256	NS
KIRP	Kidney renal papillary cell carcinoma	260	0.051	0.409	NS
LIHC	Liver hepatocellular carcinoma	347	0.071	0.185	NS
LUAD	Lung adenocarcinoma	507	0.089	0.0445	Higher
LUSC	Lung squamous cell carcinoma	497	-0.017	0.704	NS
OV	Ovarian serous cystadenocarcinoma	302	-0.174	0.00238	Lower
PAAD	Pancreatic adenocarcinoma	176	-0.059	0.435	NS
READ	Rectum adenocarcinoma	156	0.078	0.336	NS
SKCM	Skin Cutaneous Melanoma	410	0.003	0.949	NS
STAD	Stomach adenocarcinoma	392	-0.111	0.028	Lower
TGCT	Testicular Germ Cell Tumors	81	0.193	0.0846	NS
THCA	Thyroid carcinoma	499	0.179	5.83e-05	Higher
UCEC	Uterine Corpus Endometrial Carcinoma	501	0.131	0.00334	Higher

> Grade

[ TOP ]

Association between expresson and grade.

Cancer	Full Name	# Patients	R Value (Spearman)	P Value (Spearman)	Association
CESC	Cervical and endocervical cancers	272	0.1	0.101	NS
HNSC	Head and Neck squamous cell carcinoma	498	-0.046	0.301	NS
KIRC	Kidney renal clear cell carcinoma	525	-0.088	0.0444	Lower
LGG	Brain Lower Grade Glioma	514	0.038	0.395	NS
LIHC	Liver hepatocellular carcinoma	366	0.118	0.0242	Higher
OV	Ovarian serous cystadenocarcinoma	296	0.023	0.694	NS
PAAD	Pancreatic adenocarcinoma	176	0.003	0.964	NS
STAD	Stomach adenocarcinoma	406	-0.238	1.22e-06	Lower
UCEC	Uterine Corpus Endometrial Carcinoma	534	0.312	1.47e-13	Higher

Summary
Symbol	BAG6
Name	BCL2 associated athanogene 6
Aliases	G3; D6S52E; BAT3; HLA-B associated transcript 3; BAG-6; BAG family molecular chaperone regulator 6; HLA-B as ......
Location	6p21.33
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Targets inferred by reverse engineering method > Targets identified by ChIP-seq data

> Targets inferred by reverse engineering method [ TOP ]

> Targets identified by ChIP-seq data [ TOP ]

Summary
Symbol	BAG6
Name	BCL2 associated athanogene 6
Aliases	G3; D6S52E; BAT3; HLA-B associated transcript 3; BAG-6; BAG family molecular chaperone regulator 6; HLA-B as ......
Location	6p21.33
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Drugs from DrugBank database

> Drugs from DrugBank database [ TOP ]
There is no record for BAG6.

Summary
Symbol	BAG6
Name	BCL2 associated athanogene 6
Aliases	G3; D6S52E; BAT3; HLA-B associated transcript 3; BAG-6; BAG family molecular chaperone regulator 6; HLA-B as ......
Location	6p21.33
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Protein-Protein Interaction Network > miRNA Regulatory Relationship > Interactions from Text Mining

> Protein-Protein Interaction Network [ TOP ]

> miRNA Regulatory Relationship [ TOP ]
There is no record for BAG6.

> Interactions from Text Mining [ TOP ]
There is no record for BAG6.