CR2Cancer

Summary
Symbol	CHD1
Name	chromodomain helicase DNA binding protein 1
Aliases	ATP-dependent helicase CHD1; CHD-1; Chromodomain-helicase-DNA-binding protein 1
Location	5q15-q21.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Domain, Function and Classification > Gene Ontology > KEGG and Reactome Pathway

> Domain, Function and Classification

[ TOP ]

Domain

PF00385 Chromo (CHRromatin Organisation MOdifier) domain
PF13907 Domain of unknown function (DUF4208)
PF00271 Helicase conserved C-terminal domain
PF00176 SNF2 family N-terminal domain

Function

ATP-dependent chromatin-remodeling factor which functions as substrate recognition component of the transcription regulatory histone acetylation (HAT) complex SAGA. Regulates polymerase II transcription. Also required for efficient transcription by RNA polymerase I, and more specifically the polymerase I transcription termination step. Regulates negatively DNA replication. Not only involved in transcription-related chromatin-remodeling, but also required to maintain a specific chromatin configuration across the genome. Is also associated with histone deacetylase (HDAC) activity (By similarity). Required for the bridging of SNF2, the FACT complex, the PAF complex as well as the U2 snRNP complex to H3K4me3. Functions to modulate the efficiency of pre-mRNA splicing in part through physical bridging of spliceosomal components to H3K4me3. Required for maintaining open chromatin and pluripotency in embryonic stem cells.

Classification

Class	Modification	Substrate	Product	PubMed
Chromatin remodelling	#	#	#	12592387

> Gene Ontology [ TOP ]
Biological Process	GO:0006338 chromatin remodeling GO:0019058 viral life cycle GO:0019080 viral gene expression GO:0019083 viral transcription GO:0032392 DNA geometric change GO:0032508 DNA duplex unwinding GO:0035821 modification of morphology or physiology of other organism GO:0043900 regulation of multi-organism process GO:0043902 positive regulation of multi-organism process GO:0043903 regulation of symbiosis, encompassing mutualism through parasitism GO:0043921 modulation by host of viral transcription GO:0043923 positive regulation by host of viral transcription GO:0044033 multi-organism metabolic process GO:0046782 regulation of viral transcription GO:0048524 positive regulation of viral process GO:0050434 positive regulation of viral transcription GO:0050792 regulation of viral process GO:0051702 interaction with symbiont GO:0051817 modification of morphology or physiology of other organism involved in symbiotic interaction GO:0051851 modification by host of symbiont morphology or physiology GO:0052312 modulation of transcription in other organism involved in symbiotic interaction GO:0052472 modulation by host of symbiont transcription GO:0071103 DNA conformation change GO:1903900 regulation of viral life cycle GO:1903902 positive regulation of viral life cycle
Molecular Function	GO:0003678 DNA helicase activity GO:0004003 ATP-dependent DNA helicase activity GO:0004386 helicase activity GO:0008026 ATP-dependent helicase activity GO:0008094 DNA-dependent ATPase activity GO:0016887 ATPase activity GO:0035064 methylated histone binding GO:0042393 histone binding GO:0042623 ATPase activity, coupled GO:0070035 purine NTP-dependent helicase activity
Cellular Component	-

> KEGG and Reactome Pathway [ TOP ]
KEGG	-
Reactome	-

Summary
Symbol	CHD1
Name	chromodomain helicase DNA binding protein 1
Aliases	ATP-dependent helicase CHD1; CHD-1; Chromodomain-helicase-DNA-binding protein 1
Location	5q15-q21.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Mutation landscape in primary tumor tissue from TCGA > Mutation landscape in cancer cell line from CCLE > All mutations from COSMIC database V81 > Variations from text mining

> The Cancer Genome Atlas (TCGA) [ TOP ]

> Cancer Cell Line Encyclopedia (CCLE) [ TOP ]

> Catalogue of Somatic Mutations in Cancer (COSMIC)

[ TOP ]

COSMIC ID	CDS change	AA change	Mutation Type	Anatomical Site
COSM1132080	c.4877G>C	p.R1626T	Substitution - Missense	Prostate
COSM1620695	c.3875A>T	p.D1292V	Substitution - Missense	Liver
COSM3857058	c.2556T>C	p.A852A	Substitution - coding silent	Stomach
COSM3776946	c.3295G>T	p.D1099Y	Substitution - Missense	Urinary_tract
COSM1237162	c.2129T>C	p.V710A	Substitution - Missense	Parathyroid
COSM5950820	c.366A>G	p.S122S	Substitution - coding silent	Prostate
COSM5599297	c.978C>T	p.S326S	Substitution - coding silent	Skin
COSM3618955	c.3695C>T	p.P1232L	Substitution - Missense	Skin
COSM252975	c.2181-4delT	p.?	Unknown	Biliary_tract
COSM461932	c.3246C>T	p.F1082F	Substitution - coding silent	Cervix
COSM3994530	c.503A>G	p.E168G	Substitution - Missense	Kidney
COSM5563288	c.4231C>T	p.Q1411*	Substitution - Nonsense	Prostate
COSM4799699	c.2968A>G	p.M990V	Substitution - Missense	Liver
COSM3618952	c.4634C>T	p.S1545F	Substitution - Missense	Skin
COSM140517	c.5020G>T	p.G1674C	Substitution - Missense	Skin
COSM1439339	c.4259G>T	p.R1420I	Substitution - Missense	Large_intestine
COSM1071558	c.3G>T	p.M1I	Substitution - Missense	Endometrium
COSM3947826	c.3099G>T	p.E1033D	Substitution - Missense	Lung
COSM13854	c.5038G>T	p.D1680Y	Substitution - Missense	Lung
COSM3142261	c.4025T>C	p.M1342T	Substitution - Missense	Large_intestine
COSM1181008	c.629delA	p.K210fs*39	Deletion - Frameshift	Large_intestine
COSM3702866	c.1970T>A	p.L657Q	Substitution - Missense	Liver
COSM4671950	c.602delA	p.N201fs*48	Deletion - Frameshift	Large_intestine
COSM1071543	c.4390G>T	p.E1464*	Substitution - Nonsense	Endometrium
COSM199116	c.3566G>A	p.R1189Q	Substitution - Missense	Endometrium
COSM1200945	c.2089C>T	p.R697*	Substitution - Nonsense	Large_intestine
COSM1200946	c.1349C>A	p.P450H	Substitution - Missense	Large_intestine
COSM28312	c.4228G>A	p.D1410N	Substitution - Missense	Lung
COSM4888405	c.2678A>G	p.Q893R	Substitution - Missense	Upper_aerodigestive_tract
COSM4671946	c.2589C>T	p.S863S	Substitution - coding silent	Large_intestine
COSM292731	c.3960delA	p.E1321fs*22	Deletion - Frameshift	Large_intestine
COSM1071555	c.434A>C	p.K145T	Substitution - Missense	Endometrium
COSM3142261	c.4025T>C	p.M1342T	Substitution - Missense	Large_intestine
COSM4555452	c.655G>A	p.D219N	Substitution - Missense	Skin
COSM1132081	c.5043G>A	p.Q1681Q	Substitution - coding silent	Prostate
COSM4618542	c.2396G>A	p.R799H	Substitution - Missense	Large_intestine
COSM1620693	c.4902C>G	p.H1634Q	Substitution - Missense	Liver
COSM3975682	c.3752T>C	p.I1251T	Substitution - Missense	Central_nervous_system
COSM3776947	c.1565A>G	p.Y522C	Substitution - Missense	Urinary_tract
COSM1200944	c.4241T>A	p.F1414Y	Substitution - Missense	Large_intestine
COSM1439340	c.3416A>C	p.K1139T	Substitution - Missense	Large_intestine
COSM159974	c.2034G>A	p.G678G	Substitution - coding silent	Breast
COSM3776945	c.4428-2A>G	p.?	Unknown	Urinary_tract
COSM4137908	c.285C>T	p.A95A	Substitution - coding silent	Ovary
COSM50910	c.4234A>T	p.K1412*	Substitution - Nonsense	Breast
COSM310075	c.3066C>T	p.A1022A	Substitution - coding silent	Soft_tissue
COSM243665	c.4627A>G	p.S1543G	Substitution - Missense	Prostate
COSM234539	c.3942T>C	p.S1314S	Substitution - coding silent	Skin
COSM1311414	c.213A>C	p.E71D	Substitution - Missense	Urinary_tract
COSM3618954	c.3912C>T	p.T1304T	Substitution - coding silent	Skin
COSM4586097	c.396C>T	p.S132S	Substitution - coding silent	Large_intestine
COSM4945171	c.4241_4242insT	p.S1415fs*4	Insertion - Frameshift	Testis
COSM1695987	c.2432C>T	p.S811L	Substitution - Missense	Skin
COSM5061286	c.255G>T	p.E85D	Substitution - Missense	Stomach
COSM3618954	c.3912C>T	p.T1304T	Substitution - coding silent	Oesophagus
COSM1439343	c.1731G>A	p.T577T	Substitution - coding silent	Large_intestine
COSM4920538	c.3364A>G	p.N1122D	Substitution - Missense	Liver
COSM4003637	c.4335G>A	p.E1445E	Substitution - coding silent	Haematopoietic_and_lymphoid_tissue
COSM4909718	c.1825G>T	p.A609S	Substitution - Missense	Liver
COSM3142261	c.4025T>C	p.M1342T	Substitution - Missense	Large_intestine
COSM4846688	c.1954G>C	p.E652Q	Substitution - Missense	Cervix
COSM4788959	c.4563G>A	p.V1521V	Substitution - coding silent	Liver
COSM1439338	c.4285A>C	p.K1429Q	Substitution - Missense	Large_intestine
COSM5603170	c.4750G>A	p.D1584N	Substitution - Missense	Skin
COSM5521261	c.98G>T	p.G33V	Substitution - Missense	Biliary_tract
COSM5709773	c.793C>T	p.Q265*	Substitution - Nonsense	Haematopoietic_and_lymphoid_tissue
COSM199116	c.3566G>A	p.R1189Q	Substitution - Missense	Endometrium
COSM1071545	c.4174C>T	p.H1392Y	Substitution - Missense	Endometrium
COSM1487066	c.107C>G	p.S36C	Substitution - Missense	Breast
COSM738848	c.1214G>T	p.G405V	Substitution - Missense	Lung
COSM3142252	c.4641T>A	p.D1547E	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM5369503	c.930C>A	p.N310K	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM13854	c.5038G>T	p.D1680Y	Substitution - Missense	Lung
COSM3142259	c.4086G>A	p.K1362K	Substitution - coding silent	Large_intestine
COSM1439345	c.698G>A	p.R233H	Substitution - Missense	Large_intestine
COSM3947828	c.2890G>A	p.E964K	Substitution - Missense	Lung
COSM4542601	c.3215G>A	p.R1072K	Substitution - Missense	Skin
COSM1496151	c.1056T>A	p.Y352*	Substitution - Nonsense	Kidney
COSM5061285	c.1177C>T	p.R393C	Substitution - Missense	Stomach
COSM1634391	c.2729A>G	p.Y910C	Substitution - Missense	Liver
COSM5422267	c.373-3C>G	p.?	Unknown	Prostate
COSM1071554	c.732G>A	p.E244E	Substitution - coding silent	Endometrium
COSM4889411	c.2638G>T	p.V880F	Substitution - Missense	Upper_aerodigestive_tract
COSM1311413	c.683A>G	p.D228G	Substitution - Missense	Urinary_tract
COSM5825163	c.296C>A	p.S99Y	Substitution - Missense	Pancreas
COSM5918607	c.799G>A	p.E267K	Substitution - Missense	Skin
COSM3410494	c.4882C>T	p.H1628Y	Substitution - Missense	Central_nervous_system
COSM4538142	c.2506G>A	p.G836R	Substitution - Missense	Skin
COSM1620697	c.841C>A	p.R281R	Substitution - coding silent	Liver
COSM3857057	c.3563A>G	p.E1188G	Substitution - Missense	Stomach
COSM1071540	c.5010T>G	p.A1670A	Substitution - coding silent	Endometrium
COSM1071557	c.201C>A	p.D67E	Substitution - Missense	Endometrium
COSM1071547	c.4100A>G	p.D1367G	Substitution - Missense	Endometrium
COSM4671949	c.1095T>C	p.N365N	Substitution - coding silent	Large_intestine
COSM3618958	c.2088C>T	p.R696R	Substitution - coding silent	Skin
COSM3410494	c.4882C>T	p.H1628Y	Substitution - Missense	Cervix
COSM252975	c.2181-4delT	p.?	Unknown	Biliary_tract
COSM3429794	c.3295G>C	p.D1099H	Substitution - Missense	Large_intestine
COSM390253	c.481G>T	p.G161C	Substitution - Missense	Lung
COSM1329384	c.3861G>A	p.K1287K	Substitution - coding silent	Ovary
COSM1161553	c.346G>A	p.A116T	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM4957719	c.16G>A	p.D6N	Substitution - Missense	Liver
COSM5484794	c.225A>T	p.Q75H	Substitution - Missense	Large_intestine
COSM1186796	c.4556C>G	p.P1519R	Substitution - Missense	Lung
COSM5516334	c.4191T>C	p.G1397G	Substitution - coding silent	Biliary_tract
COSM4595579	c.2303C>T	p.P768L	Substitution - Missense	Upper_aerodigestive_tract
COSM1071544	c.4255G>T	p.E1419*	Substitution - Nonsense	Endometrium
COSM3857060	c.697C>T	p.R233C	Substitution - Missense	Stomach
COSM5720356	c.3610A>T	p.I1204L	Substitution - Missense	Skin
COSM1496152	c.2776G>A	p.A926T	Substitution - Missense	Kidney
COSM1620695	c.3875A>T	p.D1292V	Substitution - Missense	Liver
COSM4511850	c.882C>T	p.I294I	Substitution - coding silent	Skin
COSM3857061	c.59C>T	p.S20L	Substitution - Missense	Stomach
COSM4998389	c.2181-2delA	p.?	Unknown	Pancreas
COSM1071542	c.4721G>T	p.R1574I	Substitution - Missense	Large_intestine
COSM199116	c.3566G>A	p.R1189Q	Substitution - Missense	Large_intestine
COSM3828658	c.1135G>A	p.E379K	Substitution - Missense	Breast
COSM4615763	c.929delA	p.N310fs*10	Deletion - Frameshift	Large_intestine
COSM5573144	c.4787+2T>C	p.?	Unknown	Prostate
COSM1237162	c.2129T>C	p.V710A	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM5603169	c.1960T>G	p.W654G	Substitution - Missense	Skin
COSM5457213	c.1879T>C	p.Y627H	Substitution - Missense	Large_intestine
COSM84917	c.4734T>G	p.S1578S	Substitution - coding silent	Pancreas
COSM249177	c.2404G>A	p.E802K	Substitution - Missense	Kidney
COSM3618953	c.4312C>T	p.L1438F	Substitution - Missense	Skin
COSM5939346	c.4210G>T	p.E1404*	Substitution - Nonsense	Skin
COSM5720356	c.3610A>T	p.I1204L	Substitution - Missense	Skin
COSM1620694	c.4138A>T	p.R1380*	Substitution - Nonsense	Liver
COSM738849	c.1637A>C	p.Q546P	Substitution - Missense	Lung
COSM5720356	c.3610A>T	p.I1204L	Substitution - Missense	Skin
COSM1311412	c.3074C>G	p.S1025*	Substitution - Nonsense	Urinary_tract
COSM3994529	c.4490A>G	p.Y1497C	Substitution - Missense	Kidney
COSM252975	c.2181-4delT	p.?	Unknown	Ovary
COSM84917	c.4734T>G	p.S1578S	Substitution - coding silent	Pancreas
COSM249177	c.2404G>A	p.E802K	Substitution - Missense	Kidney
COSM292731	c.3960delA	p.E1321fs*22	Deletion - Frameshift	Stomach
COSM4818249	c.4192G>A	p.E1398K	Substitution - Missense	Cervix
COSM292731	c.3960delA	p.E1321fs*22	Deletion - Frameshift	Large_intestine
COSM1071558	c.3G>T	p.M1I	Substitution - Missense	Endometrium
COSM4401666	c.3710A>G	p.Q1237R	Substitution - Missense	Skin
COSM5663829	c.1992-1G>T	p.?	Unknown	Soft_tissue
COSM292731	c.3960delA	p.E1321fs*22	Deletion - Frameshift	Pancreas
COSM1620696	c.3874G>C	p.D1292H	Substitution - Missense	Liver
COSM4390901	c.1871C>G	p.S624C	Substitution - Missense	Breast
COSM28312	c.4228G>A	p.D1410N	Substitution - Missense	Lung
COSM4799699	c.2968A>G	p.M990V	Substitution - Missense	Liver
COSM199116	c.3566G>A	p.R1189Q	Substitution - Missense	Stomach
COSM3618961	c.1747C>T	p.R583W	Substitution - Missense	Skin
COSM1071550	c.3117T>A	p.N1039K	Substitution - Missense	Endometrium
COSM1071551	c.2609G>T	p.G870V	Substitution - Missense	Endometrium
COSM4382827	c.1097C>T	p.A366V	Substitution - Missense	Large_intestine
COSM1248195	c.2090G>A	p.R697Q	Substitution - Missense	Stomach
COSM4788959	c.4563G>A	p.V1521V	Substitution - coding silent	Liver
COSM3947827	c.2965-7A>C	p.?	Unknown	Lung
COSM3142250	c.4740T>C	p.S1580S	Substitution - coding silent	Stomach
COSM292731	c.3960delA	p.E1321fs*22	Deletion - Frameshift	Large_intestine
COSM4586097	c.396C>T	p.S132S	Substitution - coding silent	Bone
COSM292731	c.3960delA	p.E1321fs*22	Deletion - Frameshift	Large_intestine
COSM5546820	c.777_778delTG	p.C259fs*8	Deletion - Frameshift	Prostate
COSM3618962	c.1591G>T	p.G531*	Substitution - Nonsense	Skin
COSM5996035	c.4944A>G	p.E1648E	Substitution - coding silent	Prostate
COSM1071542	c.4721G>T	p.R1574I	Substitution - Missense	Large_intestine
COSM3429793	c.4872A>C	p.K1624N	Substitution - Missense	Large_intestine
COSM297797	c.1495G>A	p.G499R	Substitution - Missense	Large_intestine
COSM3662035	c.4501A>G	p.I1501V	Substitution - Missense	Liver
COSM3857059	c.1528C>A	p.L510I	Substitution - Missense	Stomach
COSM3142259	c.4086G>A	p.K1362K	Substitution - coding silent	Large_intestine
COSM74134	c.612G>T	p.K204N	Substitution - Missense	Ovary
COSM1671778	c.3791G>A	p.G1264D	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM252975	c.2181-4delT	p.?	Unknown	Biliary_tract
COSM5573870	c.630_631insA	p.R211fs*4	Insertion - Frameshift	Prostate
COSM1132079	c.2699G>A	p.R900Q	Substitution - Missense	Large_intestine
COSM3828656	c.2196G>T	p.R732S	Substitution - Missense	Breast
COSM5599297	c.978C>T	p.S326S	Substitution - coding silent	Skin
COSM292731	c.3960delA	p.E1321fs*22	Deletion - Frameshift	Stomach
COSM593780	c.4108-6C>G	p.?	Unknown	Ovary
COSM4957719	c.16G>A	p.D6N	Substitution - Missense	Liver
COSM5720356	c.3610A>T	p.I1204L	Substitution - Missense	Skin
COSM239306	c.3978+1G>T	p.?	Unknown	Prostate
COSM738847	c.995G>C	p.W332S	Substitution - Missense	Lung
COSM3618959	c.1918C>T	p.L640F	Substitution - Missense	Skin
COSM3697369	c.2544T>C	p.D848D	Substitution - coding silent	Large_intestine
COSM1200947	c.4162G>A	p.D1388N	Substitution - Missense	Large_intestine
COSM327350	c.5050_5052delCCT	p.P1684delP	Deletion - In frame	Central_nervous_system
COSM3715241	c.1538C>A	p.T513K	Substitution - Missense	Upper_aerodigestive_tract
COSM5599297	c.978C>T	p.S326S	Substitution - coding silent	Skin
COSM5615572	c.4623G>T	p.R1541S	Substitution - Missense	Lung
COSM5599297	c.978C>T	p.S326S	Substitution - coding silent	Skin
COSM327350	c.5050_5052delCCT	p.P1684delP	Deletion - In frame	Haematopoietic_and_lymphoid_tissue
COSM4877847	c.1834G>C	p.G612R	Substitution - Missense	Prostate
COSM5205935	c.2437_2438insA	p.M813fs*39	Insertion - Frameshift	Breast
COSM351287	c.4644A>T	p.R1548S	Substitution - Missense	Lung
COSM5795067	c.4236G>A	p.K1412K	Substitution - coding silent	Breast
COSM5709772	c.2056C>T	p.L686F	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM1071542	c.4721G>T	p.R1574I	Substitution - Missense	Large_intestine
COSM3142290	c.2089C>A	p.R697R	Substitution - coding silent	Upper_aerodigestive_tract
COSM5775201	c.4236G>T	p.K1412N	Substitution - Missense	Breast
COSM421133	c.3809A>G	p.Y1270C	Substitution - Missense	Urinary_tract
COSM4529792	c.1642G>A	p.E548K	Substitution - Missense	Skin
COSM4671945	c.4830C>T	p.H1610H	Substitution - coding silent	Large_intestine
COSM1620696	c.3874G>C	p.D1292H	Substitution - Missense	Liver
COSM4759177	c.3254G>A	p.S1085N	Substitution - Missense	Stomach
COSM5996036	c.4524+4A>G	p.?	Unknown	Prostate
COSM5923691	c.4222G>A	p.E1408K	Substitution - Missense	Skin
COSM5005489	c.3978G>A	p.A1326A	Substitution - coding silent	Haematopoietic_and_lymphoid_tissue
COSM4601275	c.436G>C	p.D146H	Substitution - Missense	Upper_aerodigestive_tract
COSM5692156	c.4754A>G	p.H1585R	Substitution - Missense	Soft_tissue
COSM738850	c.2059C>A	p.H687N	Substitution - Missense	Lung
COSM3947829	c.1573C>T	p.H525Y	Substitution - Missense	Lung
COSM5665295	c.1274A>T	p.D425V	Substitution - Missense	Soft_tissue
COSM310076	c.71C>T	p.S24F	Substitution - Missense	Lung
COSM5949697	c.3238-5T>G	p.?	Unknown	Haematopoietic_and_lymphoid_tissue
COSM3618956	c.3348G>A	p.R1116R	Substitution - coding silent	Skin
COSM5743076	c.418A>G	p.K140E	Substitution - Missense	Small_intestine
COSM5890072	c.5068C>T	p.P1690S	Substitution - Missense	Skin
COSM450226	c.688A>C	p.R230R	Substitution - coding silent	Breast
COSM3142264	c.3960_3961insA	p.E1321fs*17	Insertion - Frameshift	Large_intestine
COSM1071554	c.732G>A	p.E244E	Substitution - coding silent	Large_intestine
COSM4382827	c.1097C>T	p.A366V	Substitution - Missense	Large_intestine
COSM4168095	c.1114G>T	p.E372*	Substitution - Nonsense	Haematopoietic_and_lymphoid_tissue
COSM4169922	c.4562T>C	p.V1521A	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM4981001	c.4108-1G>A	p.?	Unknown	Oesophagus
COSM1179427	c.3662T>G	p.L1221*	Substitution - Nonsense	Prostate
COSM1329383	c.2334G>C	p.E778D	Substitution - Missense	Ovary
COSM1132079	c.2699G>A	p.R900Q	Substitution - Missense	Prostate
COSM3715241	c.1538C>A	p.T513K	Substitution - Missense	Upper_aerodigestive_tract
COSM4449393	c.2189delT	p.L730fs*1	Deletion - Frameshift	Skin
COSM5404070	c.1871C>T	p.S624F	Substitution - Missense	Skin
COSM5061285	c.1177C>T	p.R393C	Substitution - Missense	Large_intestine
COSM3618963	c.1038G>T	p.M346I	Substitution - Missense	Skin
COSM5404069	c.4574C>T	p.P1525L	Substitution - Missense	Skin
COSM5939347	c.2545C>T	p.H849Y	Substitution - Missense	Skin
COSM1642811	c.1494-10_1494-9insT	p.?	Unknown	Stomach
COSM4671948	c.1178G>A	p.R393H	Substitution - Missense	Large_intestine
COSM5801778	c.4066delT	p.S1356fs*15	Deletion - Frameshift	Breast
COSM294238	c.3313G>A	p.E1105K	Substitution - Missense	Large_intestine
COSM292731	c.3960delA	p.E1321fs*22	Deletion - Frameshift	Stomach
COSM4776988	c.2677C>G	p.Q893E	Substitution - Missense	Breast
COSM1071552	c.1490G>A	p.C497Y	Substitution - Missense	Endometrium
COSM5805290	c.2293A>T	p.I765F	Substitution - Missense	Liver
COSM1634389	c.5084T>C	p.V1695A	Substitution - Missense	Liver
COSM5623993	c.5045G>A	p.R1682K	Substitution - Missense	Oesophagus
COSM4671947	c.1339A>C	p.K447Q	Substitution - Missense	Large_intestine
COSM483192	c.4153T>G	p.S1385A	Substitution - Missense	Kidney
COSM1439347	c.629_630insA	p.R211fs*4	Insertion - Frameshift	Large_intestine
COSM139586	c.3820G>A	p.E1274K	Substitution - Missense	Skin
COSM1620697	c.841C>A	p.R281R	Substitution - coding silent	Liver
COSM5795686	c.1027G>A	p.V343I	Substitution - Missense	Breast
COSM3697356	c.4378G>C	p.E1460Q	Substitution - Missense	Large_intestine
COSM13854	c.5038G>T	p.D1680Y	Substitution - Missense	Lung
COSM3857055	c.4540A>G	p.N1514D	Substitution - Missense	Stomach
COSM292731	c.3960delA	p.E1321fs*22	Deletion - Frameshift	Large_intestine
COSM219973	c.3238-1G>C	p.?	Unknown	Prostate
COSM4595578	c.2302C>T	p.P768S	Substitution - Missense	Upper_aerodigestive_tract
COSM1071546	c.4146G>T	p.K1382N	Substitution - Missense	Endometrium
COSM1248196	c.2227G>C	p.G743R	Substitution - Missense	Oesophagus
COSM5450157	c.330G>A	p.Q110Q	Substitution - coding silent	Large_intestine
COSM1071553	c.986A>G	p.H329R	Substitution - Missense	Endometrium
COSM3618957	c.2479C>T	p.R827C	Substitution - Missense	Skin
COSM1071542	c.4721G>T	p.R1574I	Substitution - Missense	Endometrium
COSM1177924	c.3177A>G	p.E1059E	Substitution - coding silent	Endometrium
COSM450225	c.932A>G	p.K311R	Substitution - Missense	Breast
COSM1071541	c.4847G>T	p.R1616M	Substitution - Missense	Endometrium
COSM3142264	c.3960_3961insA	p.E1321fs*17	Insertion - Frameshift	Breast
COSM4441520	c.4574C>G	p.P1525R	Substitution - Missense	Large_intestine
COSM4003637	c.4335G>A	p.E1445E	Substitution - coding silent	Haematopoietic_and_lymphoid_tissue
COSM4648938	c.1162T>C	p.Y388H	Substitution - Missense	Large_intestine
COSM4781527	c.1451A>G	p.Y484C	Substitution - Missense	Pancreas
COSM5404071	c.83C>T	p.S28L	Substitution - Missense	Skin
COSM738846	c.1A>G	p.M1V	Substitution - Missense	Lung
COSM1071539	c.5085T>C	p.V1695V	Substitution - coding silent	Endometrium
COSM4770510	c.2915G>T	p.G972V	Substitution - Missense	Autonomic_ganglia
COSM1634392	c.114delC	p.S38fs*211	Deletion - Frameshift	Liver
COSM292731	c.3960delA	p.E1321fs*22	Deletion - Frameshift	Large_intestine
COSM738851	c.4654C>A	p.Q1552K	Substitution - Missense	Lung
COSM1634390	c.4358A>T	p.K1453I	Substitution - Missense	Liver
COSM421132	c.2080C>T	p.L694L	Substitution - coding silent	Urinary_tract
COSM1071556	c.256-1G>T	p.?	Unknown	Endometrium
COSM3618960	c.1894G>A	p.D632N	Substitution - Missense	Skin
COSM5890072	c.5068C>T	p.P1690S	Substitution - Missense	Skin
COSM3142291	c.2058T>C	p.L686L	Substitution - coding silent	Upper_aerodigestive_tract
COSM5024945	c.3881A>C	p.D1294A	Substitution - Missense	Breast
COSM3618958	c.2088C>T	p.R696R	Substitution - coding silent	Skin
COSM1071548	c.3658G>T	p.E1220*	Substitution - Nonsense	Endometrium
COSM1661121	c.1728G>T	p.W576C	Substitution - Missense	Kidney
COSM1439346	c.665_666insTGA	p.D221_E222insD	Insertion - In frame	Large_intestine
COSM327350	c.5050_5052delCCT	p.P1684delP	Deletion - In frame	Central_nervous_system
COSM3697357	c.397G>A	p.D133N	Substitution - Missense	Large_intestine
COSM3142320	c.377C>T	p.S126F	Substitution - Missense	Large_intestine
COSM243666	c.3346C>T	p.R1116W	Substitution - Missense	Prostate
COSM3662035	c.4501A>G	p.I1501V	Substitution - Missense	Liver
COSM4639546	c.3083A>G	p.D1028G	Substitution - Missense	Large_intestine
COSM1181008	c.629delA	p.K210fs*39	Deletion - Frameshift	Large_intestine
COSM1181008	c.629delA	p.K210fs*39	Deletion - Frameshift	Large_intestine
COSM1620693	c.4902C>G	p.H1634Q	Substitution - Missense	Liver
COSM3857056	c.3951T>G	p.L1317L	Substitution - coding silent	Stomach
COSM4778087	c.622C>A	p.Q208K	Substitution - Missense	Prostate
COSM5550727	c.2777C>T	p.A926V	Substitution - Missense	Prostate
COSM1659594	c.184_187delTCAG	p.E63fs*185	Deletion - Frameshift	Kidney
COSM1736949	c.2732G>A	p.R911H	Substitution - Missense	Central_nervous_system
COSM1181008	c.629delA	p.K210fs*39	Deletion - Frameshift	Large_intestine
COSM310075	c.3066C>T	p.A1022A	Substitution - coding silent	Lung
COSM1311411	c.3457C>T	p.R1153*	Substitution - Nonsense	Urinary_tract
COSM3828657	c.1860G>T	p.K620N	Substitution - Missense	Breast
COSM252975	c.2181-4delT	p.?	Unknown	Skin
COSM5599297	c.978C>T	p.S326S	Substitution - coding silent	Skin
COSM1071549	c.3189A>G	p.E1063E	Substitution - coding silent	Endometrium
COSM1620694	c.4138A>T	p.R1380*	Substitution - Nonsense	Liver
COSM5567402	c.38G>C	p.S13T	Substitution - Missense	Prostate
COSM3142257	c.4448C>G	p.S1483C	Substitution - Missense	Lung
COSM166004	c.2452_2454delGAT	p.D818delD	Deletion - In frame	Breast
COSM1439344	c.1102C>T	p.P368S	Substitution - Missense	Large_intestine
COSM4571407	c.4491T>A	p.Y1497*	Substitution - Nonsense	Skin
COSM5587486	c.2998G>A	p.E1000K	Substitution - Missense	Skin
COSM3393728	c.373-6C>G	p.?	Unknown	Pancreas
COSM159972	c.1189C>G	p.H397D	Substitution - Missense	Breast
COSM1132079	c.2699G>A	p.R900Q	Substitution - Missense	Breast
COSM4772124	c.4016A>G	p.N1339S	Substitution - Missense	Stomach
COSM3994528	c.4918C>T	p.H1640Y	Substitution - Missense	Kidney
COSM3828659	c.417C>G	p.V139V	Substitution - coding silent	Breast
COSM292731	c.3960delA	p.E1321fs*22	Deletion - Frameshift	Large_intestine

> Text Mining based Variations

[ TOP ]

PMID	Variation	Cancer	Evidence
27596623	Mutation	Prostate Carcinoma	Our findings suggest that CHD1 deletion, like BRCA1/2 mutation in ovarian cancer, may serve as a marker for prostate cancer patient stratification and the utilization of targeted therapies such as PARP inhibitors, which specifically target tumors with HR defects.
25879624	mutation	Acute Myeloid Leukemia	Transcriptome sequencing identified the chromodomain-helicase-DNA-binding protein 1 gene, CHD1, as a novel partner gene of RUNX1. We have identified CHD1 as the RUNX1 fusion partner in acute myeloid leukemia with t(5;21)(q21;q22).
28659719	Mutation	Prostate Carcinoma	Using next-generation sequencing to analyze the mutations in PC, the main molecular PC subtypes were identified, which depended on the presence of fusion genes and FOXA1, CHD1, and SPOP point mutations; other driver mutations responsible for the progression of PC subclones were also characterized.

Summary
Symbol	CHD1
Name	chromodomain helicase DNA binding protein 1
Aliases	ATP-dependent helicase CHD1; CHD-1; Chromodomain-helicase-DNA-binding protein 1
Location	5q15-q21.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Post-translational modification (PTM)

> Post-translational modification (PTM)

[ TOP ]

Filter By:

Uniprot ID	Position	Amino Acid	Description	Upstream Enzyme	Affected By Mutation	Amino Acid Sequence Variant
O14646	216	S	Phosphoserine	-	No	None detected
O14646	237	T	Phosphothreonine	-	No	None detected
O14646	241	S	Phosphoserine	-	No	None detected
O14646	250	T	Phosphothreonine	-	No	None detected
O14646	252	S	Phosphoserine	-	No	None detected
O14646	471	S	Phosphoserine	-	No	None detected
O14646	1025	S	Phosphoserine	-	Yes	p.S1025* (cancer: BLCA)
O14646	1040	S	Phosphoserine	-	No	None detected
O14646	1081	S	Phosphoserine	-	No	None detected
O14646	1096	S	Phosphoserine	-	No	None detected
O14646	1098	S	Phosphoserine	-	No	None detected
O14646	1100	S	Phosphoserine	-	No	None detected
O14646	1102	S	Phosphoserine	-	No	None detected
O14646	1161	S	Phosphoserine	-	No	None detected
O14646	1353	S	Phosphoserine	-	No	None detected
O14646	1355	S	Phosphoserine	-	No	None detected
O14646	1356	S	Phosphoserine	-	No	None detected
O14646	1360	S	Phosphoserine	-	No	None detected
O14646	1363	S	Phosphoserine	-	Yes	p.S1363P (cancer: HNSC)
O14646	1371	S	Phosphoserine	-	No	None detected
O14646	1622	S	Phosphoserine	-	No	None detected
O14646	1677	S	Phosphoserine	-	No	None detected
O14646	1689	S	Phosphoserine	-	No	None detected

Summary
Symbol	CHD1
Name	chromodomain helicase DNA binding protein 1
Aliases	ATP-dependent helicase CHD1; CHD-1; Chromodomain-helicase-DNA-binding protein 1
Location	5q15-q21.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Expression analysis in primary tumor tissue from TCGA > Expression level in cancer cell line from CCLE > Expression level in human normal tissue from HPA > Text mining based expression change

> The Cancer Genome Atlas (TCGA)

[ TOP ]

Differential expression analysis for cancers with more than 10 normal samples

Cancer	Full Name	# N	# T	Median (N)	Median (T)	LogFC	Adj. P	Status
BLCA	Bladder urothelial carcinoma	19	408	5.225	4.89	-0.565	0.000184	NS
BRCA	Breast invasive carcinoma	112	1100	5.94	5.846	-0.032	0.691	NS
CESC	Cervical and endocervical cancers	3	306	5.334	5.275	NA	NA	NA
COAD	Colon adenocarcinoma	41	459	5.478	5.516	-0.127	0.381	NS
ESCA	Esophageal carcinoma	11	185	5.661	5.811	-0.129	0.587	NS
GBM	Glioblastoma multiforme	5	166	4.224	4.918	NA	NA	NA
HNSC	Head and Neck squamous cell carcinoma	44	522	5.006	4.929	-0.045	0.677	NS
KIRC	Kidney renal clear cell carcinoma	72	534	5.184	5.545	0.356	1.47e-07	NS
KIRP	Kidney renal papillary cell carcinoma	32	291	4.927	5.037	0.047	0.72	NS
LAML	Acute Myeloid Leukemia	0	173	NA	7.057	NA	NA	NA
LGG	Brain Lower Grade Glioma	0	530	NA	4.812	NA	NA	NA
LIHC	Liver hepatocellular carcinoma	50	373	4.496	4.143	-0.338	0.000362	NS
LUAD	Lung adenocarcinoma	59	517	5.283	5.24	0.003	0.974	NS
LUSC	Lung squamous cell carcinoma	51	501	5.339	4.967	-0.446	5.29e-09	NS
OV	Ovarian serous cystadenocarcinoma	0	307	NA	4.41	NA	NA	NA
PAAD	Pancreatic adenocarcinoma	4	179	5.354	5.278	NA	NA	NA
PCPG	Pheochromocytoma and Paraganglioma	3	184	4.846	4.667	NA	NA	NA
PRAD	Prostate adenocarcinoma	52	498	4.878	4.856	-0.196	0.114	NS
READ	Rectum adenocarcinoma	10	167	5.434	5.486	-0.006	0.986	NS
SARC	Sarcoma	2	263	4.508	4.956	NA	NA	NA
SKCM	Skin Cutaneous Melanoma	1	472	5.594	5.557	NA	NA	NA
STAD	Stomach adenocarcinoma	35	415	5.138	5.624	0.426	7.14e-05	NS
TGCT	Testicular Germ Cell Tumors	0	156	NA	5.782	NA	NA	NA
THCA	Thyroid carcinoma	59	509	5.105	5.134	0.041	0.554	NS
THYM	Thymoma	2	120	7.28	6.261	NA	NA	NA
UCEC	Uterine Corpus Endometrial Carcinoma	35	546	5.296	4.853	-0.51	9.21e-05	NS

> Cancer Cell Line Encyclopedia (CCLE)

[ TOP ]

Tissue	Cell Line	Expression Level (Microarray)
Autonomic ganglia	CHP126	9.3
Autonomic ganglia	CHP212	9.4
Autonomic ganglia	IMR32	9.7
Autonomic ganglia	KELLY	9.7
Autonomic ganglia	KPNRTBM1	9.7
Autonomic ganglia	KPNSI9S	9.2
Autonomic ganglia	KPNYN	10
Autonomic ganglia	MHHNB11	10
Autonomic ganglia	NB1	9.7
Autonomic ganglia	NH6	9.5
Autonomic ganglia	SHSY5Y	9.7
Autonomic ganglia	SIMA	9.5
Autonomic ganglia	SKNAS	8.2
Autonomic ganglia	SKNBE2	9.6
Autonomic ganglia	SKNDZ	10
Autonomic ganglia	SKNFI	9
Autonomic ganglia	SKNSH	9.2
Biliary tract	HUCCT1	9.4
Biliary tract	HUH28	9.2
Biliary tract	SNU1079	9.1
Biliary tract	SNU1196	8.9
Biliary tract	SNU245	9
Biliary tract	SNU308	9.4
Biliary tract	SNU478	9.3
Bone	143B	10.1
Bone	A673	9.3
Bone	CADOES1	9.3
Bone	CAL78	9
Bone	G292CLONEA141B1	9.2
Bone	HOS	9.7
Bone	HS706T	8.7
Bone	HS737T	8.2
Bone	HS819T	8.4
Bone	HS821T	8.5
Bone	HS822T	8.3
Bone	HS863T	8.7
Bone	HS870T	8.8
Bone	HS888T	9
Bone	MG63	10
Bone	MHHES1	9.4
Bone	OUMS27	8.2
Bone	RDES	9
Bone	SJSA1	9.5
Bone	SKES1	9.7
Bone	SKNMC	10.3
Bone	SW1353	8.7
Bone	T173	8.3
Bone	TC71	9.3
Bone	U2OS	9.1
Breast	AU565	8.8
Breast	BT20	9
Breast	BT474	9
Breast	BT483	9.4
Breast	BT549	9.5
Breast	CAL120	9.3
Breast	CAL148	8.8
Breast	CAL51	10
Breast	CAL851	8.8
Breast	CAMA1	9.4
Breast	DU4475	8.2
Breast	EFM192A	9.4
Breast	EFM19	8.7
Breast	EVSAT	9.7
Breast	HCC1143	9.4
Breast	HCC1187	9.5
Breast	HCC1395	8.6
Breast	HCC1419	9.5
Breast	HCC1428	9
Breast	HCC1500	10.6
Breast	HCC1569	9.2
Breast	HCC1599	10
Breast	HCC1806	8.9
Breast	HCC1937	8.7
Breast	HCC1954	9.1
Breast	HCC202	8.4
Breast	HCC2157	9.7
Breast	HCC2218	9.7
Breast	HCC38	8.8
Breast	HCC70	8.5
Breast	HDQP1	9
Breast	HMC18	9.8
Breast	HS274T	8.6
Breast	HS281T	8.6
Breast	HS343T	8.8
Breast	HS578T	8.9
Breast	HS606T	8.3
Breast	HS739T	8.3
Breast	HS742T	8.3
Breast	JIMT1	8.9
Breast	KPL1	9.4
Breast	MCF7	9.4
Breast	MDAMB134VI	9.7
Breast	MDAMB157	8.7
Breast	MDAMB175VII	8.6
Breast	MDAMB231	9.3
Breast	MDAMB361	9
Breast	MDAMB415	9.5
Breast	MDAMB436	9.3
Breast	MDAMB453	9.1
Breast	MDAMB468	9.2
Breast	SKBR3	8.9
Breast	T47D	8.9
Breast	UACC812	9.9
Breast	UACC893	8.6
Breast	YMB1	9.3
Breast	ZR751	9.5
Breast	ZR7530	8.9
Central nervous system	1321N1	9.3
Central nervous system	42MGBA	8.3
Central nervous system	8MGBA	9
Central nervous system	A172	9.2
Central nervous system	AM38	9.4
Central nervous system	BECKER	9.3
Central nervous system	CAS1	9.2
Central nervous system	CCFSTTG1	8.9
Central nervous system	D283MED	9.6
Central nervous system	D341MED	9.4
Central nervous system	DAOY	9.6
Central nervous system	DBTRG05MG	8.9
Central nervous system	DKMG	9.4
Central nervous system	GAMG	9.8
Central nervous system	GB1	10
Central nervous system	GI1	9.3
Central nervous system	GMS10	9
Central nervous system	GOS3	8.7
Central nervous system	H4	9.5
Central nervous system	HS683	9
Central nervous system	KALS1	9.3
Central nervous system	KG1C	9.7
Central nervous system	KNS42	9
Central nervous system	KNS60	9.2
Central nervous system	KNS81	8.9
Central nervous system	KS1	9.5
Central nervous system	LN18	9.1
Central nervous system	LN229	9.4
Central nervous system	M059K	9
Central nervous system	MOGGCCM	8.9
Central nervous system	MOGGUVW	8.9
Central nervous system	NMCG1	9.1
Central nervous system	ONS76	9.6
Central nervous system	SF126	8.7
Central nervous system	SF295	9.1
Central nervous system	SNB19	9.1
Central nervous system	SNU1105	8.6
Central nervous system	SNU201	8.7
Central nervous system	SNU466	7.7
Central nervous system	SNU489	8.7
Central nervous system	SNU626	9.4
Central nervous system	SNU738	8.7
Central nervous system	SW1088	9.5
Central nervous system	SW1783	8.9
Central nervous system	T98G	8.9
Central nervous system	TM31	8.8
Central nervous system	U118MG	8.9
Central nervous system	U138MG	8.5
Central nervous system	U251MG	8.9
Central nervous system	U87MG	8.9
Central nervous system	YH13	8.9
Central nervous system	YKG1	9.2
Endometrium	AN3CA	9.6
Endometrium	COLO684	8.7
Endometrium	EFE184	9
Endometrium	EN	9.6
Endometrium	ESS1	9.1
Endometrium	HEC108	9.5
Endometrium	HEC151	9.2
Endometrium	HEC1A	8
Endometrium	HEC1B	8.5
Endometrium	HEC251	10.2
Endometrium	HEC265	9.4
Endometrium	HEC50B	9.5
Endometrium	HEC59	9.9
Endometrium	HEC6	9.2
Endometrium	ISHIKAWAHERAKLIO02ER	9.3
Endometrium	JHUEM1	8.8
Endometrium	JHUEM2	9.7
Endometrium	JHUEM3	9.9
Endometrium	KLE	8.1
Endometrium	MFE280	9.4
Endometrium	MFE296	8.8
Endometrium	MFE319	8.9
Endometrium	RL952	8.9
Endometrium	SNGM	9.2
Endometrium	SNU1077	8.1
Endometrium	SNU685	9.6
Endometrium	TEN	9.6
Haematopoietic and lymphoid	697	10.3
Haematopoietic and lymphoid	A3KAW	8.7
Haematopoietic and lymphoid	A4FUK	9.2
Haematopoietic and lymphoid	ALLSIL	10
Haematopoietic and lymphoid	AML193	9.7
Haematopoietic and lymphoid	AMO1	9.2
Haematopoietic and lymphoid	BCP1	9
Haematopoietic and lymphoid	BDCM	9.9
Haematopoietic and lymphoid	BL41	9.3
Haematopoietic and lymphoid	BL70	9.1
Haematopoietic and lymphoid	BV173	10.8
Haematopoietic and lymphoid	CA46	9.9
Haematopoietic and lymphoid	CI1	9.6
Haematopoietic and lymphoid	CMK115	10
Haematopoietic and lymphoid	CMK86	10.2
Haematopoietic and lymphoid	CMK	9.6
Haematopoietic and lymphoid	CMLT1	10
Haematopoietic and lymphoid	COLO775	9.4
Haematopoietic and lymphoid	DAUDI	8.4
Haematopoietic and lymphoid	DB	9
Haematopoietic and lymphoid	DEL	10.6
Haematopoietic and lymphoid	DND41	9.3
Haematopoietic and lymphoid	DOHH2	8.9
Haematopoietic and lymphoid	EB1	10
Haematopoietic and lymphoid	EB2	10.1
Haematopoietic and lymphoid	EHEB	10
Haematopoietic and lymphoid	EJM	8.8
Haematopoietic and lymphoid	EM2	10
Haematopoietic and lymphoid	EOL1	9.8
Haematopoietic and lymphoid	F36P	10.4
Haematopoietic and lymphoid	GA10	9.4
Haematopoietic and lymphoid	GDM1	9.8
Haematopoietic and lymphoid	GRANTA519	10.1
Haematopoietic and lymphoid	HDLM2	9.7
Haematopoietic and lymphoid	HDMYZ	9.5
Haematopoietic and lymphoid	HEL9217	9.5
Haematopoietic and lymphoid	HEL	9.7
Haematopoietic and lymphoid	HH	9.5
Haematopoietic and lymphoid	HL60	9.1
Haematopoietic and lymphoid	HPBALL	10.2
Haematopoietic and lymphoid	HS604T	8.2
Haematopoietic and lymphoid	HS611T	9.4
Haematopoietic and lymphoid	HS616T	8.4
Haematopoietic and lymphoid	HS751T	8.7
Haematopoietic and lymphoid	HT	9.7
Haematopoietic and lymphoid	HTK	9.8
Haematopoietic and lymphoid	HUNS1	9.9
Haematopoietic and lymphoid	HUT102	9.9
Haematopoietic and lymphoid	HUT78	9.6
Haematopoietic and lymphoid	JEKO1	9.7
Haematopoietic and lymphoid	JK1	10.5
Haematopoietic and lymphoid	JM1	9.9
Haematopoietic and lymphoid	JURKAT	11.3
Haematopoietic and lymphoid	JURLMK1	9.9
Haematopoietic and lymphoid	JVM2	9.6
Haematopoietic and lymphoid	JVM3	9.9
Haematopoietic and lymphoid	K562	9.3
Haematopoietic and lymphoid	KARPAS299	9.7
Haematopoietic and lymphoid	KARPAS422	9.4
Haematopoietic and lymphoid	KARPAS620	9.7
Haematopoietic and lymphoid	KASUMI1	10.6
Haematopoietic and lymphoid	KASUMI2	10.5
Haematopoietic and lymphoid	KASUMI6	9.8
Haematopoietic and lymphoid	KCL22	9.5
Haematopoietic and lymphoid	KE37	10.9
Haematopoietic and lymphoid	KE97	9.8
Haematopoietic and lymphoid	KG1	9.2
Haematopoietic and lymphoid	KHM1B	9.2
Haematopoietic and lymphoid	KIJK	10.1
Haematopoietic and lymphoid	KMH2	10.2
Haematopoietic and lymphoid	KMM1	9.6
Haematopoietic and lymphoid	KMS11	9.7
Haematopoietic and lymphoid	KMS12BM	8.7
Haematopoietic and lymphoid	KMS18	10
Haematopoietic and lymphoid	KMS20	9.7
Haematopoietic and lymphoid	KMS21BM	9.1
Haematopoietic and lymphoid	KMS26	9.2
Haematopoietic and lymphoid	KMS27	9
Haematopoietic and lymphoid	KMS28BM	9.4
Haematopoietic and lymphoid	KMS34	8.5
Haematopoietic and lymphoid	KO52	9.9
Haematopoietic and lymphoid	KOPN8	8.6
Haematopoietic and lymphoid	KU812	9.9
Haematopoietic and lymphoid	KYO1	9.6
Haematopoietic and lymphoid	L1236	10.5
Haematopoietic and lymphoid	L363	10.7
Haematopoietic and lymphoid	L428	9.5
Haematopoietic and lymphoid	L540	9.9
Haematopoietic and lymphoid	LAMA84	10.7
Haematopoietic and lymphoid	LOUCY	9.3
Haematopoietic and lymphoid	LP1	9.1
Haematopoietic and lymphoid	M07E	10.2
Haematopoietic and lymphoid	MC116	8.7
Haematopoietic and lymphoid	ME1	8.7
Haematopoietic and lymphoid	MEC1	10.3
Haematopoietic and lymphoid	MEC2	10.1
Haematopoietic and lymphoid	MEG01	10.3
Haematopoietic and lymphoid	MHHCALL2	10.3
Haematopoietic and lymphoid	MHHCALL3	10.8
Haematopoietic and lymphoid	MHHCALL4	10.6
Haematopoietic and lymphoid	MINO	10.1
Haematopoietic and lymphoid	MJ	10.1
Haematopoietic and lymphoid	MM1S	9.1
Haematopoietic and lymphoid	MOLM13	9.6
Haematopoietic and lymphoid	MOLM16	9.1
Haematopoietic and lymphoid	MOLM6	9.4
Haematopoietic and lymphoid	MOLP2	8.3
Haematopoietic and lymphoid	MOLP8	9.1
Haematopoietic and lymphoid	MOLT13	10.6
Haematopoietic and lymphoid	MOLT16	9.7
Haematopoietic and lymphoid	MOLT4	10.6
Haematopoietic and lymphoid	MONOMAC1	9.7
Haematopoietic and lymphoid	MONOMAC6	10.2
Haematopoietic and lymphoid	MOTN1	9.2
Haematopoietic and lymphoid	MUTZ5	9.7
Haematopoietic and lymphoid	MV411	9.7
Haematopoietic and lymphoid	NALM19	9.8
Haematopoietic and lymphoid	NALM1	10.7
Haematopoietic and lymphoid	NALM6	10.4
Haematopoietic and lymphoid	NAMALWA	10.1
Haematopoietic and lymphoid	NB4	10
Haematopoietic and lymphoid	NCIH929	9.4
Haematopoietic and lymphoid	NCO2	10.6
Haematopoietic and lymphoid	NOMO1	9.6
Haematopoietic and lymphoid	NUDHL1	9.2
Haematopoietic and lymphoid	NUDUL1	10.3
Haematopoietic and lymphoid	OCIAML2	9.8
Haematopoietic and lymphoid	OCIAML3	9.4
Haematopoietic and lymphoid	OCIAML5	9.7
Haematopoietic and lymphoid	OCILY10	9.6
Haematopoietic and lymphoid	OCILY19	9.7
Haematopoietic and lymphoid	OCILY3	9.7
Haematopoietic and lymphoid	OCIM1	9.9
Haematopoietic and lymphoid	OPM2	9.6
Haematopoietic and lymphoid	P12ICHIKAWA	10
Haematopoietic and lymphoid	P31FUJ	9.3
Haematopoietic and lymphoid	P3HR1	9.1
Haematopoietic and lymphoid	PCM6	9
Haematopoietic and lymphoid	PEER	10.6
Haematopoietic and lymphoid	PF382	10.7
Haematopoietic and lymphoid	PFEIFFER	10.3
Haematopoietic and lymphoid	PL21	9.8
Haematopoietic and lymphoid	RAJI	9.2
Haematopoietic and lymphoid	RCHACV	10
Haematopoietic and lymphoid	REC1	11
Haematopoietic and lymphoid	REH	10.6
Haematopoietic and lymphoid	RI1	8.9
Haematopoietic and lymphoid	RL	9.2
Haematopoietic and lymphoid	RPMI8226	9.7
Haematopoietic and lymphoid	RPMI8402	9.9
Haematopoietic and lymphoid	RS411	9.6
Haematopoietic and lymphoid	SEM	9.8
Haematopoietic and lymphoid	SET2	9.2
Haematopoietic and lymphoid	SIGM5	10.3
Haematopoietic and lymphoid	SKM1	9.6
Haematopoietic and lymphoid	SKMM2	9.5
Haematopoietic and lymphoid	SR786	9.7
Haematopoietic and lymphoid	ST486	9.7
Haematopoietic and lymphoid	SUDHL10	8.4
Haematopoietic and lymphoid	SUDHL1	10.2
Haematopoietic and lymphoid	SUDHL4	8.2
Haematopoietic and lymphoid	SUDHL5	9.8
Haematopoietic and lymphoid	SUDHL6	9.2
Haematopoietic and lymphoid	SUDHL8	9.2
Haematopoietic and lymphoid	SUPB15	9.9
Haematopoietic and lymphoid	SUPHD1	9.9
Haematopoietic and lymphoid	SUPM2	9.9
Haematopoietic and lymphoid	SUPT11	9.4
Haematopoietic and lymphoid	SUPT1	10.1
Haematopoietic and lymphoid	TALL1	10.3
Haematopoietic and lymphoid	TF1	10.3
Haematopoietic and lymphoid	THP1	9.2
Haematopoietic and lymphoid	TO175T	8.7
Haematopoietic and lymphoid	TOLEDO	9.8
Haematopoietic and lymphoid	U266B1	9.2
Haematopoietic and lymphoid	U937	9.4
Haematopoietic and lymphoid	UT7	9.8
Haematopoietic and lymphoid	WSUDLCL2	8.9
Kidney	769P	9.2
Kidney	786O	8.3
Kidney	A498	8.9
Kidney	A704	9.8
Kidney	ACHN	8.8
Kidney	BFTC909	9.8
Kidney	CAKI1	9.2
Kidney	CAKI2	8.2
Kidney	CAL54	9.4
Kidney	KMRC1	9.8
Kidney	KMRC20	9.4
Kidney	KMRC2	9.6
Kidney	KMRC3	9.4
Kidney	OSRC2	9.2
Kidney	RCC10RGB	9.1
Kidney	SNU1272	8.8
Kidney	SNU349	9.1
Kidney	TUHR10TKB	8.5
Kidney	TUHR14TKB	9.2
Kidney	TUHR4TKB	9.2
Kidney	VMRCRCW	9.6
Kidney	VMRCRCZ	8.7
Large intestine	C2BBE1	9.7
Large intestine	CCK81	9.4
Large intestine	CL11	9.5
Large intestine	CL14	9.3
Large intestine	CL34	10
Large intestine	CL40	8.8
Large intestine	COLO205	9.5
Large intestine	COLO320	9.6
Large intestine	COLO678	9.3
Large intestine	CW2	8.4
Large intestine	DLD1	9.5
Large intestine	GP2D	9.8
Large intestine	HCC56	10
Large intestine	HCT116	9.7
Large intestine	HCT15	9.7
Large intestine	HS675T	8.1
Large intestine	HS698T	8.5
Large intestine	HT115	9.8
Large intestine	HT29	9.3
Large intestine	HT55	9.9
Large intestine	KM12	10.1
Large intestine	LOVO	9.7
Large intestine	LS1034	10
Large intestine	LS123	9.1
Large intestine	LS180	8.9
Large intestine	LS411N	9.9
Large intestine	LS513	10.4
Large intestine	MDST8	8.1
Large intestine	NCIH508	8.8
Large intestine	NCIH716	9.5
Large intestine	NCIH747	9.8
Large intestine	OUMS23	9.2
Large intestine	RCM1	9.8
Large intestine	RKO	10.2
Large intestine	SKCO1	9.4
Large intestine	SNU1040	8.9
Large intestine	SNU1197	9.4
Large intestine	SNU175	9.7
Large intestine	SNU283	9.1
Large intestine	SNU407	9.2
Large intestine	SNU503	9.5
Large intestine	SNU61	8.3
Large intestine	SNU81	9.7
Large intestine	SNUC1	9.5
Large intestine	SNUC2A	8.5
Large intestine	SNUC4	8.8
Large intestine	SNUC5	10.1
Large intestine	SW1116	10.4
Large intestine	SW1417	9
Large intestine	SW1463	10
Large intestine	SW403	9.4
Large intestine	SW480	9.8
Large intestine	SW48	9.5
Large intestine	SW620	9.7
Large intestine	SW837	10.2
Large intestine	SW948	9.6
Large intestine	T84	9.3
Liver	ALEXANDERCELLS	9.2
Liver	C3A	8.9
Liver	HEP3B217	9.5
Liver	HEPG2	9.1
Liver	HLE	10
Liver	HLF	9.5
Liver	HUH1	9.4
Liver	HUH6	9.5
Liver	HUH7	9
Liver	JHH1	8.9
Liver	JHH2	9
Liver	JHH4	9.9
Liver	JHH5	9.5
Liver	JHH6	10
Liver	JHH7	10.2
Liver	LI7	9.8
Liver	PLCPRF5	9
Liver	SKHEP1	9.6
Liver	SNU182	9
Liver	SNU387	9.1
Liver	SNU398	8.6
Liver	SNU423	9.5
Liver	SNU449	8.7
Liver	SNU475	9.1
Liver	SNU761	9.5
Liver	SNU878	8.7
Liver	SNU886	9.3
Lung	A549	9.5
Lung	ABC1	8.8
Lung	BEN	8.5
Lung	CAL12T	8.6
Lung	CALU1	9.1
Lung	CALU3	10.4
Lung	CALU6	9.2
Lung	CHAGOK1	9.2
Lung	COLO668	8.6
Lung	COLO699	9.6
Lung	CORL105	9.2
Lung	CORL23	9.6
Lung	CORL24	9.3
Lung	CORL279	8.6
Lung	CORL311	8.4
Lung	CORL47	8.5
Lung	CORL51	8.2
Lung	CORL88	9.1
Lung	CORL95	8.7
Lung	CPCN	9.3
Lung	DMS114	9.5
Lung	DMS153	8.3
Lung	DMS273	9.1
Lung	DMS454	8.4
Lung	DMS53	9.2
Lung	DMS79	8.5
Lung	DV90	9.6
Lung	EBC1	9.4
Lung	EPLC272H	8.9
Lung	HARA	9.3
Lung	HCC1171	9.1
Lung	HCC1195	8
Lung	HCC15	8.9
Lung	HCC2279	9.1
Lung	HCC2935	9.8
Lung	HCC33	9.6
Lung	HCC366	9.6
Lung	HCC4006	9.4
Lung	HCC44	9.7
Lung	HCC78	9.4
Lung	HCC827	9.8
Lung	HCC95	8.9
Lung	HLC1	9.4
Lung	HLFA	8.2
Lung	HS229T	9.1
Lung	HS618T	8.5
Lung	IALM	9.8
Lung	KNS62	8.3
Lung	LC1F	9.3
Lung	LC1SQSF	8.3
Lung	LCLC103H	9.2
Lung	LCLC97TM1	10.9
Lung	LK2	9.3
Lung	LOUNH91	9.4
Lung	LU65	9.6
Lung	LU99	9.9
Lung	LUDLU1	8.4
Lung	LXF289	9.9
Lung	MORCPR	9.3
Lung	NCIH1048	9.9
Lung	NCIH1092	9.4
Lung	NCIH1105	9.1
Lung	NCIH1155	9.4
Lung	NCIH1184	9.5
Lung	NCIH1299	9.7
Lung	NCIH1339	9.1
Lung	NCIH1341	8.8
Lung	NCIH1355	9.3
Lung	NCIH1373	10
Lung	NCIH1385	9.2
Lung	NCIH1395	9.1
Lung	NCIH1435	7.7
Lung	NCIH1436	9.8
Lung	NCIH1437	9.4
Lung	NCIH146	8.3
Lung	NCIH1563	8.7
Lung	NCIH1568	9.1
Lung	NCIH1573	9.3
Lung	NCIH1581	9
Lung	NCIH1618	9
Lung	NCIH1623	9
Lung	NCIH1648	9.3
Lung	NCIH1650	9.2
Lung	NCIH1651	8.8
Lung	NCIH1666	9.4
Lung	NCIH1693	9.8
Lung	NCIH1694	9.1
Lung	NCIH1703	9.4
Lung	NCIH1734	9.2
Lung	NCIH1755	9.4
Lung	NCIH1781	9.2
Lung	NCIH1792	9.4
Lung	NCIH1793	9.4
Lung	NCIH1836	8.6
Lung	NCIH1838	9
Lung	NCIH1869	10.3
Lung	NCIH1876	9.5
Lung	NCIH1915	10
Lung	NCIH1930	8.9
Lung	NCIH1944	9.6
Lung	NCIH1963	9.8
Lung	NCIH196	8.2
Lung	NCIH1975	9.2
Lung	NCIH2009	10
Lung	NCIH2023	9
Lung	NCIH2029	9.2
Lung	NCIH2030	8.8
Lung	NCIH2066	9.3
Lung	NCIH2081	9
Lung	NCIH2085	9.4
Lung	NCIH2087	9.4
Lung	NCIH209	8.3
Lung	NCIH2106	8.2
Lung	NCIH2110	9.9
Lung	NCIH211	8.7
Lung	NCIH2122	9.5
Lung	NCIH2126	8.8
Lung	NCIH2141	9.1
Lung	NCIH2170	9.3
Lung	NCIH2171	8.2
Lung	NCIH2172	9.5
Lung	NCIH2196	9.2
Lung	NCIH2227	8.7
Lung	NCIH2228	9.8
Lung	NCIH226	9.3
Lung	NCIH2286	10
Lung	NCIH2291	9
Lung	NCIH2342	8
Lung	NCIH2347	10.2
Lung	NCIH23	9.4
Lung	NCIH2405	9.4
Lung	NCIH2444	8.8
Lung	NCIH292	9.7
Lung	NCIH322	9.5
Lung	NCIH3255	9.6
Lung	NCIH358	9.7
Lung	NCIH441	9.2
Lung	NCIH446	9.5
Lung	NCIH460	10.1
Lung	NCIH510	8.9
Lung	NCIH520	9.8
Lung	NCIH522	9.3
Lung	NCIH524	9.4
Lung	NCIH526	8.5
Lung	NCIH596	9.4
Lung	NCIH647	9
Lung	NCIH650	9.1
Lung	NCIH661	9.9
Lung	NCIH69	9.8
Lung	NCIH727	9.3
Lung	NCIH810	9.2
Lung	NCIH82	10.1
Lung	NCIH838	9.8
Lung	NCIH841	9.6
Lung	NCIH854	8.1
Lung	NCIH889	8.5
Lung	PC14	9.1
Lung	RERFLCAD1	9.6
Lung	RERFLCAD2	9.4
Lung	RERFLCAI	9.3
Lung	RERFLCKJ	8.3
Lung	RERFLCMS	8.7
Lung	RERFLCSQ1	9
Lung	SBC5	8.4
Lung	SCLC21H	10
Lung	SHP77	9.1
Lung	SKLU1	8.3
Lung	SKMES1	8.7
Lung	SQ1	9.4
Lung	SW1271	9.9
Lung	SW1573	10.1
Lung	SW900	8.8
Lung	VMRCLCD	9.5
Lung	VMRCLCP	9.1
Oesophagus	COLO680N	8.9
Oesophagus	ECGI10	9.4
Oesophagus	KYSE140	9.5
Oesophagus	KYSE150	9.6
Oesophagus	KYSE180	9.8
Oesophagus	KYSE270	9.7
Oesophagus	KYSE30	9.3
Oesophagus	KYSE410	9.6
Oesophagus	KYSE450	9.2
Oesophagus	KYSE510	9.7
Oesophagus	KYSE520	9
Oesophagus	KYSE70	8.7
Oesophagus	OE19	7.8
Oesophagus	OE33	10.3
Oesophagus	TE10	9
Oesophagus	TE11	9.4
Oesophagus	TE14	9
Oesophagus	TE15	9.2
Oesophagus	TE1	8.7
Oesophagus	TE4	9.5
Oesophagus	TE5	8.2
Oesophagus	TE6	9.4
Oesophagus	TE8	9.5
Oesophagus	TE9	9
Oesophagus	TT	9.1
Ovary	59M	9.2
Ovary	A2780	10
Ovary	CAOV3	9
Ovary	CAOV4	9.4
Ovary	COLO704	9.5
Ovary	COV318	8.1
Ovary	COV362	8.6
Ovary	COV434	9.3
Ovary	COV504	9.3
Ovary	COV644	9.2
Ovary	EFO21	10
Ovary	EFO27	8.5
Ovary	ES2	9.7
Ovary	FUOV1	9.8
Ovary	HEYA8	9.7
Ovary	HS571T	7.8
Ovary	IGROV1	8.3
Ovary	JHOC5	9
Ovary	JHOM1	8.8
Ovary	JHOM2B	10.1
Ovary	JHOS2	8.4
Ovary	JHOS4	8.4
Ovary	KURAMOCHI	8.6
Ovary	MCAS	9.4
Ovary	NIHOVCAR3	9.3
Ovary	OAW28	9
Ovary	OAW42	8.9
Ovary	OC314	9.1
Ovary	OC316	9.1
Ovary	ONCODG1	9.5
Ovary	OV56	9.5
Ovary	OV7	8.9
Ovary	OV90	9.1
Ovary	OVCAR4	9.5
Ovary	OVCAR8	9.9
Ovary	OVISE	9.1
Ovary	OVK18	7.9
Ovary	OVKATE	8.7
Ovary	OVMANA	10
Ovary	OVSAHO	9.8
Ovary	OVTOKO	8.8
Ovary	RMGI	8.8
Ovary	RMUGS	8.4
Ovary	SKOV3	9.3
Ovary	SNU119	8.5
Ovary	SNU840	9.2
Ovary	SNU8	9.4
Ovary	TOV112D	9.4
Ovary	TOV21G	9.4
Ovary	TYKNU	9.7
Pancreas	ASPC1	10
Pancreas	BXPC3	8.3
Pancreas	CAPAN1	8.2
Pancreas	CAPAN2	9.1
Pancreas	CFPAC1	9.8
Pancreas	DANG	9.1
Pancreas	HPAC	9.8
Pancreas	HPAFII	9.8
Pancreas	HS766T	8.4
Pancreas	HUPT3	9.6
Pancreas	HUPT4	9.1
Pancreas	KCIMOH1	9
Pancreas	KLM1	8.3
Pancreas	KP2	9.9
Pancreas	KP3	9.8
Pancreas	KP4	9.9
Pancreas	L33	9.1
Pancreas	MIAPACA2	10.2
Pancreas	PANC0203	10.3
Pancreas	PANC0213	9.2
Pancreas	PANC0327	9.7
Pancreas	PANC0403	8.8
Pancreas	PANC0504	8.4
Pancreas	PANC0813	9.2
Pancreas	PANC1005	9.6
Pancreas	PANC1	9.5
Pancreas	PATU8902	9.7
Pancreas	PATU8988S	9.3
Pancreas	PATU8988T	9.8
Pancreas	PK1	9.6
Pancreas	PK45H	9.3
Pancreas	PK59	9.1
Pancreas	PL45	9.8
Pancreas	PSN1	9.8
Pancreas	QGP1	9.6
Pancreas	SNU213	9.3
Pancreas	SNU324	9.3
Pancreas	SNU410	9.2
Pancreas	SU8686	9.2
Pancreas	SUIT2	10.3
Pancreas	SW1990	8.9
Pancreas	T3M4	9.4
Pancreas	TCCPAN2	9.9
Pancreas	YAPC	9.6
Pleura	ACCMESO1	9.2
Pleura	DM3	7.7
Pleura	ISTMES1	9.1
Pleura	ISTMES2	9.3
Pleura	JL1	8.5
Pleura	MPP89	9
Pleura	MSTO211H	9.6
Pleura	NCIH2052	9
Pleura	NCIH2452	9.3
Pleura	NCIH28	9.7
Prostate	22RV1	8.9
Prostate	DU145	9.5
Prostate	LNCAPCLONEFGC	8.3
Prostate	MDAPCA2B	8.9
Prostate	NCIH660	7.9
Prostate	PC3	9
Prostate	VCAP	9.2
Salivary gland	A253	9.2
Salivary gland	YD15	9.3
Skin	A101D	9
Skin	A2058	9.6
Skin	A375	9.5
Skin	C32	9.3
Skin	CHL1	9.1
Skin	CJM	9.9
Skin	COLO679	9.4
Skin	COLO741	9.7
Skin	COLO783	9.1
Skin	COLO792	8.1
Skin	COLO800	8.9
Skin	COLO818	8.6
Skin	COLO829	8.6
Skin	COLO849	9.7
Skin	G361	9.9
Skin	GRM	9
Skin	HMCB	9.5
Skin	HS294T	8.5
Skin	HS600T	8.5
Skin	HS688AT	8
Skin	HS695T	9.4
Skin	HS839T	8.6
Skin	HS852T	9.4
Skin	HS895T	8.5
Skin	HS934T	8.8
Skin	HS936T	9.4
Skin	HS939T	9.4
Skin	HS940T	8.3
Skin	HS944T	9.2
Skin	HT144	9.6
Skin	IGR1	10.1
Skin	IGR37	9.7
Skin	IGR39	9.9
Skin	IPC298	9.1
Skin	K029AX	9.6
Skin	LOXIMVI	9.6
Skin	MALME3M	8.7
Skin	MDAMB435S	9.1
Skin	MELHO	9.5
Skin	MELJUSO	9.7
Skin	MEWO	10
Skin	RPMI7951	8.9
Skin	RVH421	9.2
Skin	SH4	10.2
Skin	SKMEL1	9.5
Skin	SKMEL24	8.6
Skin	SKMEL28	10.1
Skin	SKMEL2	9.9
Skin	SKMEL30	10
Skin	SKMEL31	9.3
Skin	SKMEL3	9.3
Skin	SKMEL5	10.1
Skin	UACC257	9.3
Skin	UACC62	9.3
Skin	WM115	8.9
Skin	WM1799	9.1
Skin	WM2664	9.1
Skin	WM793	9.2
Skin	WM88	9.5
Skin	WM983B	10.2
Small intestine	HUTU80	9.6
Soft tissue	A204	9.4
Soft tissue	G401	9.7
Soft tissue	G402	9.1
Soft tissue	GCT	9.4
Soft tissue	HS729	9.8
Soft tissue	HT1080	9.3
Soft tissue	KYM1	10
Soft tissue	MESSA	9.3
Soft tissue	RD	9.5
Soft tissue	RH30	9
Soft tissue	RH41	9.4
Soft tissue	RKN	9.4
Soft tissue	S117	9
Soft tissue	SJRH30	9.9
Soft tissue	SKLMS1	8.9
Soft tissue	SKUT1	9.1
Soft tissue	TE125T	8.8
Soft tissue	TE159T	8.3
Soft tissue	TE441T	9.3
Soft tissue	TE617T	8.9
Stomach	2313287	9.6
Stomach	AGS	9.2
Stomach	AZ521	9.7
Stomach	ECC10	8.7
Stomach	ECC12	9.2
Stomach	FU97	8.7
Stomach	GCIY	9.4
Stomach	GSS	9.7
Stomach	GSU	9.2
Stomach	HGC27	9.7
Stomach	HS746T	8.9
Stomach	HUG1N	8
Stomach	IM95	8.9
Stomach	KATOIII	9.2
Stomach	KE39	9
Stomach	LMSU	9.3
Stomach	MKN1	9.5
Stomach	MKN45	10.1
Stomach	MKN74	9.4
Stomach	MKN7	9.1
Stomach	NCCSTCK140	8.1
Stomach	NCIN87	9.5
Stomach	NUGC2	8.4
Stomach	NUGC3	8.9
Stomach	NUGC4	9.6
Stomach	OCUM1	9.7
Stomach	RERFGC1B	9
Stomach	SH10TC	9.4
Stomach	SNU16	9.3
Stomach	SNU1	9.5
Stomach	SNU216	8.6
Stomach	SNU520	8.8
Stomach	SNU5	10.4
Stomach	SNU601	9.1
Stomach	SNU620	7.9
Stomach	SNU668	9.2
Stomach	SNU719	9.4
Stomach	TGBC11TKB	9.6
Thyroid	8305C	8.6
Thyroid	8505C	9.6
Thyroid	BCPAP	8.9
Thyroid	BHT101	9.6
Thyroid	CAL62	10.1
Thyroid	CGTHW1	8.1
Thyroid	FTC133	8.6
Thyroid	FTC238	9.2
Thyroid	ML1	9.7
Thyroid	SW579	7.7
Thyroid	TT2609C02	9.4
Thyroid	TT	9.2
Upper aerodigestive tract	BHY	9.3
Upper aerodigestive tract	BICR16	8.3
Upper aerodigestive tract	BICR18	9.2
Upper aerodigestive tract	BICR22	9.2
Upper aerodigestive tract	BICR31	8.7
Upper aerodigestive tract	BICR56	9.5
Upper aerodigestive tract	BICR6	9.2
Upper aerodigestive tract	CAL27	9.1
Upper aerodigestive tract	CAL33	9.1
Upper aerodigestive tract	DETROIT562	9.3
Upper aerodigestive tract	FADU	9.8
Upper aerodigestive tract	HS840T	8.6
Upper aerodigestive tract	HSC2	9.4
Upper aerodigestive tract	HSC3	9.7
Upper aerodigestive tract	HSC4	8.7
Upper aerodigestive tract	PECAPJ15	9.2
Upper aerodigestive tract	PECAPJ34CLONEC12	9.4
Upper aerodigestive tract	PECAPJ41CLONED2	8.9
Upper aerodigestive tract	PECAPJ49	8.7
Upper aerodigestive tract	SCC15	8.4
Upper aerodigestive tract	SCC25	8.5
Upper aerodigestive tract	SCC4	8.9
Upper aerodigestive tract	SCC9	9.3
Upper aerodigestive tract	SNU1076	8.5
Upper aerodigestive tract	SNU1214	7.5
Upper aerodigestive tract	SNU46	9.6
Upper aerodigestive tract	SNU899	8.9
Upper aerodigestive tract	YD10B	9
Upper aerodigestive tract	YD38	9.9
Upper aerodigestive tract	YD8	8.7
Urinary tract	5637	9
Urinary tract	639V	8.9
Urinary tract	647V	9.2
Urinary tract	BC3C	9.2
Urinary tract	BFTC905	9.4
Urinary tract	CAL29	8.9
Urinary tract	HS172T	8.5
Urinary tract	HT1197	8.4
Urinary tract	HT1376	8.8
Urinary tract	J82	8.7
Urinary tract	JMSU1	9.4
Urinary tract	KMBC2	9
Urinary tract	KU1919	9.4
Urinary tract	RT11284	9.1
Urinary tract	RT112	8.8
Urinary tract	RT4	9.3
Urinary tract	SCABER	9
Urinary tract	SW1710	8.8
Urinary tract	SW780	9.5
Urinary tract	T24	9.2
Urinary tract	TCCSUP	9.7
Urinary tract	UMUC1	8.4
Urinary tract	UMUC3	9.7
Urinary tract	VMCUB1	9.7

> The Human Protein Atlas (HPA)

[ TOP ]

Tissue	Expression Level (TPM)
Adipose tissue	17.1
Adrenal gland	13.6
Appendix	24.9
Bone marrow	44.4
Breast	11.3
Cerebral cortex	9.3
Cervix, uterine	12.2
Colon	10.5
Duodenum	10.1
Endometrium	20.8
Epididymis	8.4
Esophagus	8.8
Fallopian tube	10.8
Gallbladder	24.1
Heart muscle	3.4
Kidney	9
Liver	6.9
Lung	14.1
Lymph node	16.6
Ovary	15.7
Pancreas	2.1
Parathyroid gland	20.1
Placenta	20.2
Prostate	12.3
Rectum	11.6
Salivary gland	2.2
Seminal vesicle	9.8
Skeletal muscle	1.3
Skin	7.4
Small intestine	10.6
Smooth muscle	13.1
Spleen	22
Stomach	7.7
Testis	33.6
Thyroid gland	14.7
Tonsil	13.3
Urinary bladder	10.7

> Text Mining based Expression

[ TOP ]

PMID	Expression	Cancer	Evidence
22179824	Underexpression (copy number loss)	Prostate Carcinoma	Expression of CHD1 was significantly reduced in tumors with deletion (P=0.03), and compared with normal prostate (P=0.04).
28383660	Loss of expression	Prostate Carcinoma	CHD1 loss sensitizes prostate cancer to DNA damaging therapy by promoting error-prone double-strand break repair.
27596623	Loss of expression	Prostate Carcinoma	Loss of CHD1 causes DNA repair defects and enhances prostate cancer therapeutic responsiveness. The CHD1 gene, encoding the chromo-domain helicase DNA-binding protein-1, is one of the most frequently deleted genes in prostate cancer.
27753448	Loss of expression	Prostate Carcinoma	Deletions of CHD1 are not infrequent in PCa and may associate with increased AR activity and genomic instability, and these tumours could benefit from DNA-damaging therapies.

Summary
Symbol	CHD1
Name	chromodomain helicase DNA binding protein 1
Aliases	ATP-dependent helicase CHD1; CHD-1; Chromodomain-helicase-DNA-binding protein 1
Location	5q15-q21.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Somatic copy number alteration in primary tomur tissue

> The Cancer Genome Atlas (TCGA)

[ TOP ]

Correlation between expression and SCNA as well as percentage of patients in different status.

Cancer	Full Name	# Sample	R	P	% Loss	% Neutral	% Gain	Status
BLCA	Bladder urothelial carcinoma	404	0.555	5.84e-34	48.5	44.6	6.9	Loss
BRCA	Breast invasive carcinoma	1075	0.447	7.33e-54	25.8	56	18.2	Neutral
CESC	Cervical and endocervical cancers	292	0.497	1.36e-19	24.7	67.5	7.9	Neutral
COAD	Colon adenocarcinoma	449	0.329	9.1e-13	27.6	65.9	6.5	Neutral
ESCA	Esophageal carcinoma	183	0.492	1.59e-12	55.7	39.9	4.4	Loss
GBM	Glioblastoma multiforme	147	0.177	0.0317	12.2	81	6.8	Neutral
HNSC	Head and Neck squamous cell carcinoma	514	0.46	2.65e-28	42	52.3	5.6	Loss
KIRC	Kidney renal clear cell carcinoma	525	0.275	1.48e-10	1.7	55	43.2	Gain
KIRP	Kidney renal papillary cell carcinoma	288	0.234	6.06e-05	3.8	84.4	11.8	Neutral
LAML	Acute Myeloid Leukemia	166	0.486	3.23e-11	7.2	92.8	0	Neutral
LGG	Brain Lower Grade Glioma	513	0.225	2.54e-07	7.8	90.1	2.1	Neutral
LIHC	Liver hepatocellular carcinoma	364	0.372	2.22e-13	13.2	57.7	29.1	Neutral
LUAD	Lung adenocarcinoma	512	0.518	1.6e-36	40.2	42.4	17.4	Loss
LUSC	Lung squamous cell carcinoma	498	0.377	2.67e-18	77.7	20.1	2.2	Loss
OV	Ovarian serous cystadenocarcinoma	300	0.667	4.71e-40	63	30	7	Loss
PAAD	Pancreatic adenocarcinoma	177	0.228	0.00232	16.4	75.7	7.9	Neutral
PCPG	Pheochromocytoma and Paraganglioma	162	0.323	2.8e-05	7.4	88.3	4.3	Neutral
PRAD	Prostate adenocarcinoma	491	0.67	3.81e-65	22.6	75.4	2	Neutral
READ	Rectum adenocarcinoma	164	0.273	0.000403	31.1	57.9	11	Neutral
SARC	Sarcoma	255	0.388	1.34e-10	16.1	56.9	27.1	Neutral
SKCM	Skin Cutaneous Melanoma	367	0.39	9.46e-15	27.2	58.3	14.4	Neutral
STAD	Stomach adenocarcinoma	413	0.506	2.95e-28	37	58.1	4.8	Loss
TGCT	Testicular Germ Cell Tumors	150	0.118	0.15	69.3	27.3	3.3	Loss
THCA	Thyroid carcinoma	497	-0.038	0.393	0	96.4	3.6	Neutral
THYM	Thymoma	119	-0.087	0.348	1.7	90.8	7.6	Neutral
UCEC	Uterine Corpus Endometrial Carcinoma	537	0.329	4.69e-15	18.8	78.6	2.6	Neutral

Summary
Symbol	CHD1
Name	chromodomain helicase DNA binding protein 1
Aliases	ATP-dependent helicase CHD1; CHD-1; Chromodomain-helicase-DNA-binding protein 1
Location	5q15-q21.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Methylation level in the promoter region of CR

> Methylation level in the promoter region of CR

[ TOP ]

Correlation between expression and methylation as well as differential methylation analysis.

Cancer	Full Name	R	P	# N	# T	Delta beta (T vs N)	P value (T vs N)	Status
BLCA	Bladder urothelial carcinoma	-0.264	3.86e-08	17	408	0	0.183	NS/NA
BRCA	Breast invasive carcinoma	-0.175	2.35e-07	83	785	-0.003	0.194	NS/NA
CESC	Cervical and endocervical cancers	-0.25	9.61e-06	3	306	NA	NA	NS/NA
COAD	Colon adenocarcinoma	-0.329	2.64e-09	19	297	0.003	0.472	NS/NA
ESCA	Esophageal carcinoma	-0.312	1.02e-05	9	185	NA	NA	NS/NA
GBM	Glioblastoma multiforme	-0.404	0.00093	1	64	NA	NA	NS/NA
HNSC	Head and Neck squamous cell carcinoma	-0.277	6.09e-11	20	522	0.005	0.000599	NS/NA
KIRC	Kidney renal clear cell carcinoma	-0.011	0.842	24	319	0.003	0.0595	NS/NA
KIRP	Kidney renal papillary cell carcinoma	-0.078	0.178	23	275	0.007	1.03e-06	NS/NA
LAML	Acute Myeloid Leukemia	-0.143	0.0634	0	170	NA	NA	NS/NA
LGG	Brain Lower Grade Glioma	-0.14	0.00126	0	530	NA	NA	NS/NA
LIHC	Liver hepatocellular carcinoma	-0.176	0.00034	41	373	0.022	1.66e-22	NS/NA
LUAD	Lung adenocarcinoma	-0.087	0.0582	21	456	-0.003	0.772	NS/NA
LUSC	Lung squamous cell carcinoma	-0.048	0.349	8	370	NA	NA	NS/NA
OV	Ovarian serous cystadenocarcinoma	-0.6	0.0968	0	9	NA	NA	NS/NA
PAAD	Pancreatic adenocarcinoma	-0.251	0.000629	4	179	NA	NA	NS/NA
PCPG	Pheochromocytoma and Paraganglioma	-0.074	0.312	3	184	NA	NA	NS/NA
PRAD	Prostate adenocarcinoma	-0.335	2.66e-15	35	498	0.009	5.38e-18	NS/NA
READ	Rectum adenocarcinoma	-0.433	7.41e-06	2	99	NA	NA	NS/NA
SARC	Sarcoma	-0.258	2.35e-05	0	263	NA	NA	NS/NA
SKCM	Skin Cutaneous Melanoma	-0.305	1.6e-11	1	471	NA	NA	NS/NA
STAD	Stomach adenocarcinoma	-0.347	7.37e-12	0	372	NA	NA	NS/NA
TGCT	Testicular Germ Cell Tumors	-0.299	0.000163	0	156	NA	NA	NS/NA
THCA	Thyroid carcinoma	-0.056	0.185	50	509	-0.011	7.81e-10	NS/NA
THYM	Thymoma	-0.188	0.0378	2	120	NA	NA	NS/NA
UCEC	Uterine Corpus Endometrial Carcinoma	-0.165	0.000368	34	431	0.002	6.03e-06	NS/NA

Summary
Symbol	CHD1
Name	chromodomain helicase DNA binding protein 1
Aliases	ATP-dependent helicase CHD1; CHD-1; Chromodomain-helicase-DNA-binding protein 1
Location	5q15-q21.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Primary tumor tissue from TCGA > Normal tumor tissue from HPA

>The Cancer Genome Atlas (TCGA) [ TOP ]
There is no record.

> The Human Protein Atlas (HPA)

[ TOP ]

Tissue	Level	Level Name
Adrenal gland	0	Not detected
Appendix	3	High
Bone marrow	0	Not detected
Breast	1	Low
Bronchus	2	Medium
Caudate	2	Medium
Cerebellum	2	Medium
Cerebral cortex	2	Medium
Cervix, uterine	2	Medium
Colon	3	High
Duodenum	2	Medium
Endometrium	1	Low
Epididymis	1	Low
Esophagus	2	Medium
Fallopian tube	2	Medium
Gallbladder	2	Medium
Heart muscle	1	Low
Hippocampus	1	Low
Kidney	3	High
Liver	2	Medium
Lung	0	Not detected
Lymph node	2	Medium
Nasopharynx	2	Medium
Oral mucosa	2	Medium
Ovary	3	High
Pancreas	2	Medium
Parathyroid gland	1	Low
Placenta	3	High
Prostate	1	Low
Rectum	2	Medium
Salivary gland	2	Medium
Seminal vesicle	0	Not detected
Skeletal muscle	0	Not detected
Skin	2	Medium
Small intestine	2	Medium
Smooth muscle	2	Medium
Soft tissue	2	Medium
Spleen	0	Not detected
Stomach	2	Medium
Testis	2	Medium
Thyroid gland	2	Medium
Tonsil	2	Medium
Urinary bladder	2	Medium
Vagina	2	Medium

Summary
Symbol	CHD1
Name	chromodomain helicase DNA binding protein 1
Aliases	ATP-dependent helicase CHD1; CHD-1; Chromodomain-helicase-DNA-binding protein 1
Location	5q15-q21.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Association between expresson and subtype > Overall survival analysis based on expression > Association between expresson and stage > Association between expresson and grade

> Subtype

[ TOP ]

Association between expresson and subtype.

Cancer	Full Name	# Patients	P Value (Kruskal-Wallis)	Association	Source
BLCA	Bladder urothelial carcinoma	128	0.64	NS	24476821
BRCA	Breast invasive carcinoma	521	1.71e-26	Significant	23000897
COAD	Colon adenocarcinoma	149	0.0367	Significant	22810696
GBM	Glioblastoma multiforme	157	0.000172	Significant	26824661
HNSC	Head and Neck squamous cell carcinoma	279	0.0387	Significant	25631445
KIRP	Kidney renal papillary cell carcinoma	161	0.864	NS	26536169
LGG	Brain Lower Grade Glioma	513	0.00102	Significant	26824661
LUAD	Lung adenocarcinoma	230	0.832	NS	25079552
LUSC	Lung squamous cell carcinoma	178	0.000187	Significant	22960745
OV	Ovarian serous cystadenocarcinoma	287	0.082	NS	21720365
PRAD	Prostate adenocarcinoma	333	9.98e-15	Significant	26544944
READ	Rectum adenocarcinoma	67	0.146	NS	22810696
SKCM	Skin Cutaneous Melanoma	315	0.0695	NS	26091043
STAD	Stomach adenocarcinoma	277	3.1e-08	Significant	25079317
THCA	Thyroid carcinoma	391	1.56e-10	Significant	25417114
UCEC	Uterine Corpus Endometrial Carcinoma	232	0.443	NS	23636398

> Overall survival

[ TOP ]

Overall survival analysis based on expression.

Cancer	Full Name	# Patients	Hazard Ratio	P Value (Log Rank Test)	Association
BLCA	Bladder urothelial carcinoma	405	0.985	0.943	NS
BRCA	Breast invasive carcinoma	1079	0.985	0.953	NS
CESC	Cervical and endocervical cancers	291	1.197	0.591	NS
COAD	Colon adenocarcinoma	439	0.5	0.0224	Longer
ESCA	Esophageal carcinoma	184	1.468	0.205	NS
GBM	Glioblastoma multiforme	158	0.975	0.918	NS
HNSC	Head and Neck squamous cell carcinoma	518	0.735	0.112	NS
KIRC	Kidney renal clear cell carcinoma	531	1.101	0.66	NS
KIRP	Kidney renal papillary cell carcinoma	287	1.895	0.125	NS
LAML	Acute Myeloid Leukemia	149	0.509	0.0181	Longer
LGG	Brain Lower Grade Glioma	511	2.736	7.67e-05	Shorter
LIHC	Liver hepatocellular carcinoma	365	0.691	0.156	NS
LUAD	Lung adenocarcinoma	502	1.358	0.144	NS
LUSC	Lung squamous cell carcinoma	494	1.16	0.451	NS
OV	Ovarian serous cystadenocarcinoma	303	0.976	0.911	NS
PAAD	Pancreatic adenocarcinoma	177	1.622	0.0858	NS
PCPG	Pheochromocytoma and Paraganglioma	179	558226856.841	0.0942	NS
PRAD	Prostate adenocarcinoma	497	1.029	0.972	NS
READ	Rectum adenocarcinoma	159	0.459	0.176	NS
SARC	Sarcoma	259	1.308	0.377	NS
SKCM	Skin Cutaneous Melanoma	459	0.767	0.165	NS
STAD	Stomach adenocarcinoma	388	0.918	0.716	NS
TGCT	Testicular Germ Cell Tumors	134	0	0.326	NS
THCA	Thyroid carcinoma	500	3.764	0.197	NS
THYM	Thymoma	119	0	0.012	Longer
UCEC	Uterine Corpus Endometrial Carcinoma	543	1.196	0.578	NS

> Stage

[ TOP ]

Association between expresson and stage.

Cancer	Full Name	# Patients	R Value (Spearman)	P Value (Spearman)	Association
BLCA	Bladder urothelial carcinoma	406	-0.108	0.029	Lower
BRCA	Breast invasive carcinoma	1071	-0.012	0.697	NS
CESC	Cervical and endocervical cancers	167	0.025	0.752	NS
COAD	Colon adenocarcinoma	445	-0.049	0.298	NS
ESCA	Esophageal carcinoma	162	-0.064	0.417	NS
HNSC	Head and Neck squamous cell carcinoma	448	-0.008	0.867	NS
KIRC	Kidney renal clear cell carcinoma	531	0	0.996	NS
KIRP	Kidney renal papillary cell carcinoma	260	0.055	0.378	NS
LIHC	Liver hepatocellular carcinoma	347	0.024	0.655	NS
LUAD	Lung adenocarcinoma	507	0.092	0.0374	Higher
LUSC	Lung squamous cell carcinoma	497	0.019	0.679	NS
OV	Ovarian serous cystadenocarcinoma	302	-0.008	0.894	NS
PAAD	Pancreatic adenocarcinoma	176	0.037	0.628	NS
READ	Rectum adenocarcinoma	156	-0.044	0.584	NS
SKCM	Skin Cutaneous Melanoma	410	-0.021	0.668	NS
STAD	Stomach adenocarcinoma	392	0.099	0.0497	Higher
TGCT	Testicular Germ Cell Tumors	81	-0.241	0.0302	Lower
THCA	Thyroid carcinoma	499	0.002	0.967	NS
UCEC	Uterine Corpus Endometrial Carcinoma	501	0.067	0.134	NS

> Grade

[ TOP ]

Association between expresson and grade.

Cancer	Full Name	# Patients	R Value (Spearman)	P Value (Spearman)	Association
CESC	Cervical and endocervical cancers	272	-0.182	0.00259	Lower
HNSC	Head and Neck squamous cell carcinoma	498	0.043	0.34	NS
KIRC	Kidney renal clear cell carcinoma	525	-0.086	0.0499	Lower
LGG	Brain Lower Grade Glioma	514	0.265	1.01e-09	Higher
LIHC	Liver hepatocellular carcinoma	366	-0.001	0.988	NS
OV	Ovarian serous cystadenocarcinoma	296	0.06	0.305	NS
PAAD	Pancreatic adenocarcinoma	176	0.008	0.919	NS
STAD	Stomach adenocarcinoma	406	0.105	0.0349	Higher
UCEC	Uterine Corpus Endometrial Carcinoma	534	0.106	0.0142	Higher

Summary
Symbol	CHD1
Name	chromodomain helicase DNA binding protein 1
Aliases	ATP-dependent helicase CHD1; CHD-1; Chromodomain-helicase-DNA-binding protein 1
Location	5q15-q21.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Targets inferred by reverse engineering method > Targets identified by ChIP-seq data

> Targets inferred by reverse engineering method [ TOP ]

> Targets identified by ChIP-seq data [ TOP ]

Summary
Symbol	CHD1
Name	chromodomain helicase DNA binding protein 1
Aliases	ATP-dependent helicase CHD1; CHD-1; Chromodomain-helicase-DNA-binding protein 1
Location	5q15-q21.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Drugs from DrugBank database

> Drugs from DrugBank database

[ TOP ]

DrugBank ID	Name	Type	All Targets
DB00445	Epirubicin	Small Molecule Drug

Summary
Symbol	CHD1
Name	chromodomain helicase DNA binding protein 1
Aliases	ATP-dependent helicase CHD1; CHD-1; Chromodomain-helicase-DNA-binding protein 1
Location	5q15-q21.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Protein-Protein Interaction Network > miRNA Regulatory Relationship > Interactions from Text Mining

> Protein-Protein Interaction Network [ TOP ]

> miRNA Regulatory Relationship [ TOP ]

> Interactions from Text Mining

[ TOP ]

PMID	Cancer	Hierarchy	Gene	Relation to CR	Evidence
25879624	Acute Myeloid Leukemia	partner	RUNX1	Fusion	Transcriptome sequencing identified the chromodomain-helicase-DNA-binding protein 1 gene, CHD1, as a novel partner gene of RUNX1. We have identified CHD1 as the RUNX1 fusion partner in acute myeloid leukemia with t(5;21)(q21;q22).