CR2Cancer

Summary
Symbol	DNMT3B
Name	DNA methyltransferase 3 beta
Aliases	ICF; ICF1; M.HsaIIIB; DNA MTase HsaIIIB; DNA methyltransferase HsaIIIB; DNA (cytosine-5)-methyltransferase 3 ......
Location	20q11.21
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Domain, Function and Classification > Gene Ontology > KEGG and Reactome Pathway

> Domain, Function and Classification

[ TOP ]

Domain

PF00145 C-5 cytosine-specific DNA methylase
PF00855 PWWP domain

Function

Required for genome-wide de novo methylation and is essential for the establishment of DNA methylation patterns during development. DNA methylation is coordinated with methylation of histones. May preferentially methylates nucleosomal DNA within the nucleosome core region. May function as transcriptional co-repressor by associating with CBX4 and independently of DNA methylation. Seems to be involved in gene silencing (By similarity). In association with DNMT1 and via the recruitment of CTCFL/BORIS, involved in activation of BAG1 gene expression by modulating dimethylation of promoter histone H3 at H3K4 and H3K9. Isoforms 4 and 5 are probably not functional due to the deletion of two conserved methyltransferase motifs. Function as transcriptional corepressor by associating with ZHX1. Required for DUX4 silencing in somatic cells (PubMed:27153398).

Classification

Class	Modification	Substrate	Product	PubMed
DNA modification	DNA methylation	dhC	dhU	10325416

> Gene Ontology [ TOP ]
Biological Process	GO:0001666 response to hypoxia GO:0006304 DNA modification GO:0006305 DNA alkylation GO:0006306 DNA methylation GO:0006479 protein methylation GO:0006790 sulfur compound metabolic process GO:0007584 response to nutrient GO:0008213 protein alkylation GO:0009116 nucleoside metabolic process GO:0009119 ribonucleoside metabolic process GO:0009314 response to radiation GO:0009636 response to toxic substance GO:0009991 response to extracellular stimulus GO:0010212 response to ionizing radiation GO:0010424 DNA methylation on cytosine within a CG sequence GO:0010720 positive regulation of cell development GO:0014074 response to purine-containing compound GO:0014823 response to activity GO:0016570 histone modification GO:0016571 histone methylation GO:0018022 peptidyl-lysine methylation GO:0018205 peptidyl-lysine modification GO:0031000 response to caffeine GO:0031056 regulation of histone modification GO:0031057 negative regulation of histone modification GO:0031058 positive regulation of histone modification GO:0031060 regulation of histone methylation GO:0031061 negative regulation of histone methylation GO:0031062 positive regulation of histone methylation GO:0031667 response to nutrient levels GO:0031960 response to corticosteroid GO:0032259 methylation GO:0032355 response to estradiol GO:0032776 DNA methylation on cytosine GO:0033189 response to vitamin A GO:0033273 response to vitamin GO:0034968 histone lysine methylation GO:0036293 response to decreased oxygen levels GO:0036295 cellular response to increased oxygen levels GO:0036296 response to increased oxygen levels GO:0040029 regulation of gene expression, epigenetic GO:0042220 response to cocaine GO:0042278 purine nucleoside metabolic process GO:0042493 response to drug GO:0043279 response to alkaloid GO:0043414 macromolecule methylation GO:0044728 DNA methylation or demethylation GO:0045666 positive regulation of neuron differentiation GO:0045814 negative regulation of gene expression, epigenetic GO:0046128 purine ribonucleoside metabolic process GO:0046498 S-adenosylhomocysteine metabolic process GO:0046499 S-adenosylmethioninamine metabolic process GO:0048545 response to steroid hormone GO:0050769 positive regulation of neurogenesis GO:0051384 response to glucocorticoid GO:0051567 histone H3-K9 methylation GO:0051568 histone H3-K4 methylation GO:0051569 regulation of histone H3-K4 methylation GO:0051570 regulation of histone H3-K9 methylation GO:0051571 positive regulation of histone H3-K4 methylation GO:0051573 negative regulation of histone H3-K9 methylation GO:0051962 positive regulation of nervous system development GO:0055093 response to hyperoxia GO:0061647 histone H3-K9 modification GO:0070482 response to oxygen levels GO:0071383 cellular response to steroid hormone stimulus GO:0071384 cellular response to corticosteroid stimulus GO:0071385 cellular response to glucocorticoid stimulus GO:0071396 cellular response to lipid GO:0071407 cellular response to organic cyclic compound GO:0071453 cellular response to oxygen levels GO:0071455 cellular response to hyperoxia GO:0071548 response to dexamethasone GO:0071549 cellular response to dexamethasone stimulus GO:0090116 C-5 methylation of cytosine GO:1901605 alpha-amino acid metabolic process GO:1901654 response to ketone GO:1901655 cellular response to ketone GO:1901657 glycosyl compound metabolic process GO:1902275 regulation of chromatin organization GO:1905268 negative regulation of chromatin organization GO:1905269 positive regulation of chromatin organization
Molecular Function	GO:0003682 chromatin binding GO:0003714 transcription corepressor activity GO:0003886 DNA (cytosine-5-)-methyltransferase activity GO:0008168 methyltransferase activity GO:0008757 S-adenosylmethionine-dependent methyltransferase activity GO:0009008 DNA-methyltransferase activity GO:0016741 transferase activity, transferring one-carbon groups GO:0042826 histone deacetylase binding GO:0045322 unmethylated CpG binding GO:0051718 DNA (cytosine-5-)-methyltransferase activity, acting on CpG substrates
Cellular Component	-

> KEGG and Reactome Pathway [ TOP ]
KEGG	hsa00270 Cysteine and methionine metabolism hsa01100 Metabolic pathways
Reactome	R-HSA-5334118: DNA methylation R-HSA-212165: Epigenetic regulation of gene expression R-HSA-74160: Gene Expression R-HSA-5250941: Negative epigenetic regulation of rRNA expression R-HSA-427413: NoRC negatively regulates rRNA expression R-HSA-212300: PRC2 methylates histones and DNA

Summary
Symbol	DNMT3B
Name	DNA methyltransferase 3 beta
Aliases	ICF; ICF1; M.HsaIIIB; DNA MTase HsaIIIB; DNA methyltransferase HsaIIIB; DNA (cytosine-5)-methyltransferase 3 ......
Location	20q11.21
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Mutation landscape in primary tumor tissue from TCGA > Mutation landscape in cancer cell line from CCLE > All mutations from COSMIC database V81 > Variations from text mining

> The Cancer Genome Atlas (TCGA) [ TOP ]

> Cancer Cell Line Encyclopedia (CCLE) [ TOP ]

> Catalogue of Somatic Mutations in Cancer (COSMIC)

[ TOP ]

COSMIC ID	CDS change	AA change	Mutation Type	Anatomical Site
COSM5343574	c.2047C>T	p.R683C	Substitution - Missense	Large_intestine
COSM1411120	c.557delC	p.Y188fs*4	Deletion - Frameshift	Large_intestine
COSM2149381	c.1634G>A	p.R545H	Substitution - Missense	Central_nervous_system
COSM4798512	c.588G>A	p.Q196Q	Substitution - coding silent	Liver
COSM2889621	c.2236G>A	p.V746M	Substitution - Missense	Skin
COSM356487	c.342_343GG>TT	p.R114>?	Complex	Lung
COSM4291286	c.2368C>T	p.P790S	Substitution - Missense	Skin
COSM4962214	c.2421G>C	p.R807S	Substitution - Missense	Pancreas
COSM4974104	c.1413C>T	p.D471D	Substitution - coding silent	Oesophagus
COSM4134443	c.1674T>C	p.Y558Y	Substitution - coding silent	Thyroid
COSM4134439	c.1321A>G	p.K441E	Substitution - Missense	Thyroid
COSM118756	c.723C>G	p.A241A	Substitution - coding silent	Ovary
COSM4097611	c.2343C>T	p.I781I	Substitution - coding silent	Stomach
COSM2889502	c.516C>T	p.D172D	Substitution - coding silent	Stomach
COSM3911099	c.1614C>T	p.R538R	Substitution - coding silent	Skin
COSM4773297	c.655-3C>A	p.?	Unknown	Stomach
COSM1411123	c.1353delG	p.L454fs*136	Deletion - Frameshift	Large_intestine
COSM5934004	c.182C>T	p.S61F	Substitution - Missense	Skin
COSM3389676	c.1636C>A	p.L546M	Substitution - Missense	Pancreas
COSM5723097	c.2215C>T	p.L739L	Substitution - coding silent	Skin
COSM4097605	c.1726C>T	p.R576*	Substitution - Nonsense	Skin
COSM2889486	c.335C>T	p.S112F	Substitution - Missense	Oesophagus
COSM310681	c.1603G>A	p.V535I	Substitution - Missense	Lung
COSM2889482	c.248A>G	p.D83G	Substitution - Missense	Large_intestine
COSM1740655	c.1591C>T	p.R531C	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM4581723	c.1446C>T	p.C482C	Substitution - coding silent	Bone
COSM1411133	c.1881C>T	p.D627D	Substitution - coding silent	Large_intestine
COSM2889480	c.225C>T	p.D75D	Substitution - coding silent	Large_intestine
COSM4944548	c.433-2A>T	p.?	Unknown	Liver
COSM1411123	c.1353delG	p.L454fs*136	Deletion - Frameshift	Large_intestine
COSM723106	c.1040G>A	p.G347D	Substitution - Missense	Lung
COSM3785383	c.1804G>A	p.V602I	Substitution - Missense	Pancreas
COSM1204304	c.43G>A	p.G15S	Substitution - Missense	Large_intestine
COSM5723097	c.2215C>T	p.L739L	Substitution - coding silent	Skin
COSM4878226	c.179T>C	p.V60A	Substitution - Missense	Prostate
COSM1025777	c.204+1G>A	p.?	Unknown	Oesophagus
COSM1025791	c.685G>A	p.V229M	Substitution - Missense	Endometrium
COSM70508	c.2155G>T	p.V719L	Substitution - Missense	Ovary
COSM723101	c.2304A>G	p.L768L	Substitution - coding silent	Lung
COSM1615458	c.1718G>T	p.R573L	Substitution - Missense	Liver
COSM1641322	c.1006G>C	p.A336P	Substitution - Missense	Stomach
COSM2889480	c.225C>T	p.D75D	Substitution - coding silent	Large_intestine
COSM1196453	c.14C>G	p.T5S	Substitution - Missense	Lung
COSM1025789	c.540G>A	p.T180T	Substitution - coding silent	Large_intestine
COSM5002008	c.1229G>T	p.R410L	Substitution - Missense	Pancreas
COSM3911101	c.2333C>T	p.S778L	Substitution - Missense	Skin
COSM139181	c.59C>T	p.S20L	Substitution - Missense	Skin
COSM1713331	c.1228C>T	p.R410*	Substitution - Nonsense	Skin
COSM4799400	c.2162T>C	p.I721T	Substitution - Missense	Liver
COSM4506465	c.684C>T	p.L228L	Substitution - coding silent	Skin
COSM3545299	c.475C>T	p.P159S	Substitution - Missense	Skin
COSM4097607	c.1754C>T	p.A585V	Substitution - Missense	Stomach
COSM5434539	c.1520T>C	p.L507P	Substitution - Missense	Oesophagus
COSM2889482	c.248A>G	p.D83G	Substitution - Missense	Large_intestine
COSM3545317	c.2452G>A	p.V818M	Substitution - Missense	Skin
COSM4752115	c.1010A>C	p.H337P	Substitution - Missense	Stomach
COSM1615458	c.1718G>T	p.R573L	Substitution - Missense	Liver
COSM4971201	c.1461G>A	p.L487L	Substitution - coding silent	Central_nervous_system
COSM1411116	c.310C>T	p.R104*	Substitution - Nonsense	Large_intestine
COSM1641322	c.1006G>C	p.A336P	Substitution - Missense	Stomach
COSM2889623	c.2272G>A	p.D758N	Substitution - Missense	Large_intestine
COSM4678913	c.481C>A	p.P161T	Substitution - Missense	Large_intestine
COSM1250499	c.1755G>A	p.A585A	Substitution - coding silent	Oesophagus
COSM403770	c.738G>T	p.W246C	Substitution - Missense	Lung
COSM478011	c.2132C>A	p.S711*	Substitution - Nonsense	Kidney
COSM5574190	c.1150G>A	p.A384T	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM3389676	c.1636C>A	p.L546M	Substitution - Missense	Large_intestine
COSM3545313	c.2060G>A	p.G687D	Substitution - Missense	Skin
COSM1411129	c.1727G>A	p.R576Q	Substitution - Missense	Large_intestine
COSM4097603	c.1717C>T	p.R573W	Substitution - Missense	Stomach
COSM1025803	c.1532G>A	p.G511D	Substitution - Missense	Endometrium
COSM1204302	c.2048G>A	p.R683H	Substitution - Missense	Large_intestine
COSM1025785	c.317G>A	p.R106Q	Substitution - Missense	Endometrium
COSM3545297	c.421C>T	p.P141S	Substitution - Missense	Skin
COSM3545293	c.394C>T	p.H132Y	Substitution - Missense	Skin
COSM3972511	c.132G>A	p.P44P	Substitution - coding silent	Central_nervous_system
COSM4097597	c.1434C>A	p.C478*	Substitution - Nonsense	Stomach
COSM1681613	c.2020G>A	p.E674K	Substitution - Missense	Large_intestine
COSM1632233	c.1371A>C	p.T457T	Substitution - coding silent	Liver
COSM1025799	c.1253-1G>T	p.?	Unknown	Endometrium
COSM1681613	c.2020G>A	p.E674K	Substitution - Missense	Large_intestine
COSM2889574	c.1539G>A	p.A513A	Substitution - coding silent	Stomach
COSM4532779	c.1918G>A	p.G640S	Substitution - Missense	Skin
COSM443642	c.2240T>C	p.I747T	Substitution - Missense	Breast
COSM4134441	c.1572T>C	p.C524C	Substitution - coding silent	Thyroid
COSM3991631	c.364C>G	p.R122G	Substitution - Missense	Kidney
COSM723103	c.2232G>T	p.R744S	Substitution - Missense	Lung
COSM280553	c.1941C>T	p.G647G	Substitution - coding silent	Large_intestine
COSM3733767	c.2429G>T	p.G810V	Substitution - Missense	Pancreas
COSM1683280	c.1320_1321insGC	p.K441fs*150	Insertion - Frameshift	Kidney
COSM4495117	c.410C>T	p.P137L	Substitution - Missense	Skin
COSM1025801	c.1478C>T	p.T493M	Substitution - Missense	Endometrium
COSM4996006	c.2463G>T	p.M821I	Substitution - Missense	Upper_aerodigestive_tract
COSM3720056	c.2559A>G	p.E853E	Substitution - coding silent	Haematopoietic_and_lymphoid_tissue
COSM5891162	c.608C>T	p.P203L	Substitution - Missense	Skin
COSM325193	c.1675-2A>T	p.?	Unknown	Lung
COSM3545315	c.2280G>A	p.L760L	Substitution - coding silent	Skin
COSM4097591	c.102G>A	p.S34S	Substitution - coding silent	Stomach
COSM3840745	c.217G>A	p.D73N	Substitution - Missense	Breast
COSM4555852	c.634G>A	p.G212R	Substitution - Missense	Skin
COSM4097595	c.720C>A	p.P240P	Substitution - coding silent	Stomach
COSM2889529	c.934C>T	p.R312*	Substitution - Nonsense	Stomach
COSM1718671	c.2051C>T	p.P684L	Substitution - Missense	Skin
COSM3927767	c.1326C>A	p.N442K	Substitution - Missense	Prostate
COSM723108	c.584G>T	p.S195I	Substitution - Missense	Lung
COSM1681613	c.2020G>A	p.E674K	Substitution - Missense	Large_intestine
COSM1025775	c.151T>C	p.S51P	Substitution - Missense	Endometrium
COSM1411125	c.1633C>T	p.R545C	Substitution - Missense	Large_intestine
COSM352957	c.460G>T	p.A154S	Substitution - Missense	Lung
COSM4556667	c.33G>A	p.E11E	Substitution - coding silent	Skin
COSM3545319	c.2518C>T	p.R840*	Substitution - Nonsense	Skin
COSM418988	c.809C>G	p.S270C	Substitution - Missense	Urinary_tract
COSM1411114	c.263C>T	p.P88L	Substitution - Missense	Large_intestine
COSM5495635	c.1127-2A>G	p.?	Unknown	Biliary_tract
COSM4164671	c.795C>T	p.G265G	Substitution - coding silent	Kidney
COSM2889472	c.66C>T	p.L22L	Substitution - coding silent	Upper_aerodigestive_tract
COSM1411131	c.1846G>A	p.V616M	Substitution - Missense	Large_intestine
COSM126659	c.2197C>T	p.R733*	Substitution - Nonsense	Upper_aerodigestive_tract
COSM1483543	c.343G>A	p.E115K	Substitution - Missense	Breast
COSM3545287	c.63C>T	p.I21I	Substitution - coding silent	Skin
COSM1025797	c.1249C>T	p.R417*	Substitution - Nonsense	Endometrium
COSM1284576	c.154A>C	p.S52R	Substitution - Missense	Autonomic_ganglia
COSM5824140	c.1378G>T	p.D460Y	Substitution - Missense	Liver
COSM1713333	c.1447G>A	p.E483K	Substitution - Missense	Large_intestine
COSM1025783	c.285G>A	p.R95R	Substitution - coding silent	Endometrium
COSM4557379	c.689G>A	p.W230*	Substitution - Nonsense	Skin
COSM1681611	c.1753G>A	p.A585T	Substitution - Missense	Ovary
COSM1025793	c.895C>T	p.R299*	Substitution - Nonsense	Large_intestine
COSM5648615	c.15C>A	p.T5T	Substitution - coding silent	Oesophagus
COSM3423581	c.2334G>A	p.S778S	Substitution - coding silent	Oesophagus
COSM3545303	c.548G>A	p.S183N	Substitution - Missense	Skin
COSM3423581	c.2334G>A	p.S778S	Substitution - coding silent	Large_intestine
COSM723105	c.1088G>A	p.R363H	Substitution - Missense	Lung
COSM4492376	c.360C>T	p.S120S	Substitution - coding silent	Skin
COSM1740655	c.1591C>T	p.R531C	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM4097599	c.1704C>T	p.P568P	Substitution - coding silent	Stomach
COSM5574188	c.2292G>T	p.R764S	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM1411135	c.2115C>T	p.G705G	Substitution - coding silent	Large_intestine
COSM3423577	c.306+1G>C	p.?	Unknown	Large_intestine
COSM1025781	c.222C>T	p.G74G	Substitution - coding silent	Endometrium
COSM260532	c.97G>A	p.D33N	Substitution - Missense	Large_intestine
COSM3670238	c.1058C>T	p.T353M	Substitution - Missense	Central_nervous_system
COSM2889614	c.2134C>T	p.R712W	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM3423579	c.458C>T	p.S153L	Substitution - Missense	Large_intestine
COSM5642798	c.1899G>A	p.K633K	Substitution - coding silent	Oesophagus
COSM1025809	c.1935G>A	p.V645V	Substitution - coding silent	Endometrium
COSM1025813	c.2417A>G	p.E806G	Substitution - Missense	Endometrium
COSM2889610	c.2019C>T	p.F673F	Substitution - coding silent	Skin
COSM5015662	c.338G>C	p.S113T	Substitution - Missense	Kidney
COSM167729	c.274C>T	p.R92W	Substitution - Missense	Large_intestine
COSM1411123	c.1353delG	p.L454fs*136	Deletion - Frameshift	Large_intestine
COSM5707379	c.476C>T	p.P159L	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM3545301	c.525G>A	p.E175E	Substitution - coding silent	Skin
COSM3545311	c.2058G>A	p.E686E	Substitution - coding silent	Skin
COSM3545295	c.420C>T	p.F140F	Substitution - coding silent	Skin
COSM5723097	c.2215C>T	p.L739L	Substitution - coding silent	Skin
COSM3545291	c.369C>T	p.S123S	Substitution - coding silent	Skin
COSM1411118	c.536G>T	p.G179V	Substitution - Missense	Large_intestine
COSM4097593	c.289C>T	p.R97C	Substitution - Missense	Stomach
COSM1250501	c.1454G>A	p.R485Q	Substitution - Missense	Oesophagus
COSM3963476	c.225C>A	p.D75E	Substitution - Missense	Lung
COSM1745166	c.1456_1478del23	p.L489fs*57	Deletion - Frameshift	Urinary_tract
COSM310681	c.1603G>A	p.V535I	Substitution - Missense	Large_intestine
COSM5723097	c.2215C>T	p.L739L	Substitution - coding silent	Skin
COSM5755559	c.427A>G	p.T143A	Substitution - Missense	Large_intestine
COSM4097605	c.1726C>T	p.R576*	Substitution - Nonsense	Skin
COSM3911101	c.2333C>T	p.S778L	Substitution - Missense	Skin
COSM3545289	c.316C>T	p.R106*	Substitution - Nonsense	Skin
COSM95831	c.813G>A	p.E271E	Substitution - coding silent	Lung
COSM3545295	c.420C>T	p.F140F	Substitution - coding silent	Skin
COSM3785383	c.1804G>A	p.V602I	Substitution - Missense	Stomach
COSM4798512	c.588G>A	p.Q196Q	Substitution - coding silent	Liver
COSM3991633	c.609G>A	p.P203P	Substitution - coding silent	Kidney
COSM3545305	c.719C>T	p.P240L	Substitution - Missense	Skin
COSM2889582	c.1613G>A	p.R538H	Substitution - Missense	Large_intestine
COSM1025805	c.1609C>T	p.R537W	Substitution - Missense	Large_intestine
COSM2889537	c.998T>C	p.L333S	Substitution - Missense	Large_intestine
COSM4678915	c.517G>A	p.D173N	Substitution - Missense	Large_intestine
COSM1411122	c.1102A>C	p.R368R	Substitution - coding silent	Large_intestine
COSM1615456	c.1641G>A	p.Q547Q	Substitution - coding silent	Liver
COSM1025805	c.1609C>T	p.R537W	Substitution - Missense	Stomach
COSM4513133	c.891C>T	p.S297S	Substitution - coding silent	Skin
COSM1025777	c.204+1G>A	p.?	Unknown	Endometrium
COSM1025779	c.211A>G	p.T71A	Substitution - Missense	Endometrium
COSM1411127	c.1716G>C	p.R572S	Substitution - Missense	Large_intestine
COSM4491016	c.336C>T	p.S112S	Substitution - coding silent	Skin
COSM1411131	c.1846G>A	p.V616M	Substitution - Missense	Large_intestine
COSM3911101	c.2333C>T	p.S778L	Substitution - Missense	Large_intestine
COSM1025805	c.1609C>T	p.R537W	Substitution - Missense	Endometrium
COSM3389678	c.1907T>A	p.I636N	Substitution - Missense	Pancreas
COSM1025787	c.438G>A	p.L146L	Substitution - coding silent	Endometrium
COSM1025789	c.540G>A	p.T180T	Substitution - coding silent	Large_intestine
COSM5561240	c.2288A>G	p.N763S	Substitution - Missense	Prostate
COSM1025793	c.895C>T	p.R299*	Substitution - Nonsense	Haematopoietic_and_lymphoid_tissue
COSM1025789	c.540G>A	p.T180T	Substitution - coding silent	Endometrium
COSM478009	c.1491G>T	p.R497R	Substitution - coding silent	Kidney
COSM6008549	c.856C>T	p.H286Y	Substitution - Missense	Prostate
COSM4550443	c.464G>A	p.G155E	Substitution - Missense	Skin
COSM256806	c.1261G>A	p.A421T	Substitution - Missense	Large_intestine
COSM3545299	c.475C>T	p.P159S	Substitution - Missense	Skin
COSM5891164	c.607C>T	p.P203S	Substitution - Missense	Skin
COSM1615454	c.96C>T	p.S32S	Substitution - coding silent	Liver
COSM4799400	c.2162T>C	p.I721T	Substitution - Missense	Liver
COSM4521585	c.1119G>A	p.R373R	Substitution - coding silent	Skin
COSM3701610	c.2561A>T	p.*854L	Nonstop extension	Liver
COSM2889542	c.1155C>T	p.D385D	Substitution - coding silent	Large_intestine
COSM3545307	c.1497C>T	p.F499F	Substitution - coding silent	Skin
COSM94144	c.113T>C	p.L38P	Substitution - Missense	Lung
COSM5751991	c.1222_1223insC	p.K408fs*6	Insertion - Frameshift	Haematopoietic_and_lymphoid_tissue
COSM2889550	c.1193G>A	p.R398H	Substitution - Missense	Stomach
COSM4134439	c.1321A>G	p.K441E	Substitution - Missense	Skin
COSM4097601	c.1712G>A	p.R571Q	Substitution - Missense	Stomach
COSM4134443	c.1674T>C	p.Y558Y	Substitution - coding silent	Thyroid
COSM220216	c.2072C>T	p.P691L	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM3740083	c.1457A>G	p.E486G	Substitution - Missense	Liver
COSM1718671	c.2051C>T	p.P684L	Substitution - Missense	Skin
COSM3545321	c.2533C>T	p.P845S	Substitution - Missense	Skin
COSM1713333	c.1447G>A	p.E483K	Substitution - Missense	Skin
COSM327789	c.158C>T	p.S53L	Substitution - Missense	Skin
COSM4678911	c.474G>A	p.W158*	Substitution - Nonsense	Large_intestine
COSM2889582	c.1613G>A	p.R538H	Substitution - Missense	Large_intestine
COSM4164673	c.2188C>T	p.H730Y	Substitution - Missense	Kidney
COSM77601	c.1209C>G	p.C403W	Substitution - Missense	Ovary
COSM1615456	c.1641G>A	p.Q547Q	Substitution - coding silent	Liver
COSM1025807	c.1879G>A	p.D627N	Substitution - Missense	Endometrium
COSM3405019	c.129C>T	p.T43T	Substitution - coding silent	Central_nervous_system
COSM1242202	c.1125C>T	p.Y375Y	Substitution - coding silent	Oesophagus
COSM2889544	c.1156G>A	p.D386N	Substitution - Missense	Skin
COSM4097609	c.2086T>C	p.F696L	Substitution - Missense	Stomach
COSM1204300	c.1647C>A	p.F549L	Substitution - Missense	Large_intestine
COSM4678917	c.995T>C	p.M332T	Substitution - Missense	Large_intestine
COSM1025793	c.895C>T	p.R299*	Substitution - Nonsense	Endometrium
COSM2889600	c.1803C>T	p.Y601Y	Substitution - coding silent	Stomach
COSM3727315	c.2339C>T	p.S780L	Substitution - Missense	Skin
COSM1025811	c.2340G>A	p.S780S	Substitution - coding silent	Endometrium
COSM2149381	c.1634G>A	p.R545H	Substitution - Missense	Central_nervous_system
COSM5036337	c.1909G>C	p.E637Q	Substitution - Missense	Oesophagus
COSM2149381	c.1634G>A	p.R545H	Substitution - Missense	Stomach
COSM1025785	c.317G>A	p.R106Q	Substitution - Missense	Biliary_tract
COSM5924742	c.2459A>G	p.N820S	Substitution - Missense	Skin
COSM1713335	c.1750A>T	p.I584F	Substitution - Missense	Skin
COSM2889525	c.906G>A	p.M302I	Substitution - Missense	Large_intestine
COSM1565845	c.1834G>A	p.A612T	Substitution - Missense	Large_intestine
COSM3545289	c.316C>T	p.R106*	Substitution - Nonsense	Liver
COSM1238712	c.1183G>A	p.A395T	Substitution - Missense	Prostate
COSM3728024	c.592G>C	p.G198R	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM25335	c.813+5G>A	p.?	Unknown	Lung
COSM1483545	c.687G>A	p.V229V	Substitution - coding silent	Breast
COSM3972513	c.251C>G	p.T84S	Substitution - Missense	Central_nervous_system
COSM1615454	c.96C>T	p.S32S	Substitution - coding silent	Liver
COSM4678909	c.348G>A	p.R116R	Substitution - coding silent	Large_intestine
COSM2889502	c.516C>T	p.D172D	Substitution - coding silent	Stomach
COSM5550643	c.2530G>A	p.A844T	Substitution - Missense	Prostate
COSM1238712	c.1183G>A	p.A395T	Substitution - Missense	Oesophagus
COSM3770766	c.389G>A	p.R130H	Substitution - Missense	Pancreas
COSM4602266	c.1555C>T	p.Q519*	Substitution - Nonsense	Upper_aerodigestive_tract
COSM1495031	c.1243C>A	p.Q415K	Substitution - Missense	Kidney
COSM4097605	c.1726C>T	p.R576*	Substitution - Nonsense	Stomach
COSM3991635	c.2082G>C	p.W694C	Substitution - Missense	Kidney
COSM3545309	c.1693C>T	p.P565S	Substitution - Missense	Skin
COSM2889572	c.1445G>A	p.C482Y	Substitution - Missense	Large_intestine
COSM1238712	c.1183G>A	p.A395T	Substitution - Missense	Lung
COSM1025795	c.1139G>A	p.R380Q	Substitution - Missense	Endometrium
COSM185171	c.1138C>T	p.R380*	Substitution - Nonsense	Endometrium
COSM1724511	c.1906-6_1906-5delTT	p.?	Unknown	Skin
COSM3545295	c.420C>T	p.F140F	Substitution - coding silent	Skin
COSM5513609	c.2467C>T	p.R823C	Substitution - Missense	Biliary_tract
COSM5806202	c.717G>T	p.W239C	Substitution - Missense	Liver

> Text Mining based Variations

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PMID	Variation	Cancer	Evidence
15528220	Mutation	Lung Carcinoma	These results suggest that the DNMT3B -283T > C polymorphism influences DNMT3B expression, thus contributing to the genetic susceptibility to lung cancer.
16773201	Mutation	Non-Small Cell Lung Carcinoma	In non-small cell lung cancer (NSCLC) cell lines, DeltaDNMT3B variants are frequently expressed and are the predominant forms of DNMT3B.
18006804	Mutation	Lung Carcinoma	DeltaDNMT3Bs are the predominant expression forms of DNMT3B in human lung cancer.
25769449	Mutation	Colorectal Carcinoma	Our results suggest that DNMT3b polymorphism is involved in the development of colon cancer and non-random genes promoter methylation among Iranian population.
26629529	Mutation	Lung Carcinoma	In this study, we found that most of the lung cancer cell lines tested predominantly expressed DNMT3B isoforms without exons 21, 22 or both 21 and 22 (a region corresponding to the enzymatic domain of DNMT3B) termed DNMT3B/DNMT3B-del.

Summary
Symbol	DNMT3B
Name	DNA methyltransferase 3 beta
Aliases	ICF; ICF1; M.HsaIIIB; DNA MTase HsaIIIB; DNA methyltransferase HsaIIIB; DNA (cytosine-5)-methyltransferase 3 ......
Location	20q11.21
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Post-translational modification (PTM)

> Post-translational modification (PTM)

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Filter By:

Uniprot ID	Position	Amino Acid	Description	Upstream Enzyme	Affected By Mutation	Amino Acid Sequence Variant
Q9UBC3	96	T	Phosphothreonine	-	No	None detected
Q9UBC3	100	S	Phosphoserine	-	No	None detected
Q9UBC3	110	S	Phosphoserine	-	No	None detected
Q9UBC3	136	S	Phosphoserine	-	No	None detected
Q9UBC3	195	S	Phosphoserine	-	Yes	p.S195I (cancer: LUSC)
Q9UBC3	202	S	Phosphoserine	-	No	None detected
Q9UBC3	209	S	Phosphoserine	-	No	None detected
Q9UBC3	410	R	Citrulline	-	No	None detected

Summary
Symbol	DNMT3B
Name	DNA methyltransferase 3 beta
Aliases	ICF; ICF1; M.HsaIIIB; DNA MTase HsaIIIB; DNA methyltransferase HsaIIIB; DNA (cytosine-5)-methyltransferase 3 ......
Location	20q11.21
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Expression analysis in primary tumor tissue from TCGA > Expression level in cancer cell line from CCLE > Expression level in human normal tissue from HPA > Text mining based expression change

> The Cancer Genome Atlas (TCGA)

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Differential expression analysis for cancers with more than 10 normal samples

Cancer	Full Name	# N	# T	Median (N)	Median (T)	LogFC	Adj. P	Status
BLCA	Bladder urothelial carcinoma	19	408	1.258	3.627	2.428	3.62e-13	Over
BRCA	Breast invasive carcinoma	112	1100	1.452	2.603	1.296	8.86e-29	Over
CESC	Cervical and endocervical cancers	3	306	0.7	3.134	NA	NA	NA
COAD	Colon adenocarcinoma	41	459	0.829	2.377	1.632	6.02e-23	Over
ESCA	Esophageal carcinoma	11	185	0.516	3.603	2.744	1.49e-09	Over
GBM	Glioblastoma multiforme	5	166	0.172	1.384	NA	NA	NA
HNSC	Head and Neck squamous cell carcinoma	44	522	0.829	3.188	2.188	2.05e-29	Over
KIRC	Kidney renal clear cell carcinoma	72	534	1.318	1.715	0.432	0.000387	NS
KIRP	Kidney renal papillary cell carcinoma	32	291	1.56	2.928	1.369	4.71e-11	Over
LAML	Acute Myeloid Leukemia	0	173	NA	5.313	NA	NA	NA
LGG	Brain Lower Grade Glioma	0	530	NA	0.788	NA	NA	NA
LIHC	Liver hepatocellular carcinoma	50	373	-0.651	0.725	1.615	1.26e-17	Over
LUAD	Lung adenocarcinoma	59	517	0.454	2.016	1.751	2.88e-22	Over
LUSC	Lung squamous cell carcinoma	51	501	0.424	2.952	2.613	9.56e-44	Over
OV	Ovarian serous cystadenocarcinoma	0	307	NA	3.737	NA	NA	NA
PAAD	Pancreatic adenocarcinoma	4	179	2.108	1.738	NA	NA	NA
PCPG	Pheochromocytoma and Paraganglioma	3	184	-0.374	0.641	NA	NA	NA
PRAD	Prostate adenocarcinoma	52	498	0.049	0.576	0.584	7.9e-05	Over
READ	Rectum adenocarcinoma	10	167	0.561	2.601	2.111	2.92e-08	Over
SARC	Sarcoma	2	263	1.004	1.923	NA	NA	NA
SKCM	Skin Cutaneous Melanoma	1	472	2.117	1.984	NA	NA	NA
STAD	Stomach adenocarcinoma	35	415	0.682	2.634	2.111	3.68e-16	Over
TGCT	Testicular Germ Cell Tumors	0	156	NA	5.533	NA	NA	NA
THCA	Thyroid carcinoma	59	509	1.977	1.29	-0.519	6.74e-07	NS
THYM	Thymoma	2	120	2.914	2.803	NA	NA	NA
UCEC	Uterine Corpus Endometrial Carcinoma	35	546	1.128	3.911	2.614	8.04e-37	Over

> Cancer Cell Line Encyclopedia (CCLE)

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Tissue	Cell Line	Expression Level (Microarray)
Autonomic ganglia	CHP126	8.2
Autonomic ganglia	CHP212	7.2
Autonomic ganglia	IMR32	8
Autonomic ganglia	KELLY	8.1
Autonomic ganglia	KPNRTBM1	8
Autonomic ganglia	KPNSI9S	7.7
Autonomic ganglia	KPNYN	7.6
Autonomic ganglia	MHHNB11	9.2
Autonomic ganglia	NB1	8.3
Autonomic ganglia	NH6	7.5
Autonomic ganglia	SHSY5Y	8.1
Autonomic ganglia	SIMA	7.6
Autonomic ganglia	SKNAS	6.6
Autonomic ganglia	SKNBE2	7.3
Autonomic ganglia	SKNDZ	8.5
Autonomic ganglia	SKNFI	7.5
Autonomic ganglia	SKNSH	7.3
Biliary tract	HUCCT1	7.6
Biliary tract	HUH28	8.2
Biliary tract	SNU1079	9.2
Biliary tract	SNU1196	8
Biliary tract	SNU245	6.1
Biliary tract	SNU308	7.8
Biliary tract	SNU478	8.7
Bone	143B	7.9
Bone	A673	6.7
Bone	CADOES1	6.1
Bone	CAL78	6.7
Bone	G292CLONEA141B1	7.4
Bone	HOS	9
Bone	HS706T	7.1
Bone	HS737T	6.3
Bone	HS819T	4.9
Bone	HS821T	7.4
Bone	HS822T	5.4
Bone	HS863T	6.4
Bone	HS870T	6.8
Bone	HS888T	6.9
Bone	MG63	7.6
Bone	MHHES1	8.5
Bone	OUMS27	7.5
Bone	RDES	7.8
Bone	SJSA1	7.3
Bone	SKES1	7.2
Bone	SKNMC	7.6
Bone	SW1353	7.4
Bone	T173	6.5
Bone	TC71	7.7
Bone	U2OS	9.1
Breast	AU565	8.1
Breast	BT20	8
Breast	BT474	9.5
Breast	BT483	8.9
Breast	BT549	6.4
Breast	CAL120	6.3
Breast	CAL148	10.4
Breast	CAL51	8.8
Breast	CAL851	6.9
Breast	CAMA1	9.6
Breast	DU4475	7.8
Breast	EFM192A	6.7
Breast	EFM19	8.5
Breast	EVSAT	8.1
Breast	HCC1143	10
Breast	HCC1187	8.1
Breast	HCC1395	7.6
Breast	HCC1419	8
Breast	HCC1428	8.6
Breast	HCC1500	8.9
Breast	HCC1569	8.2
Breast	HCC1599	8.2
Breast	HCC1806	9.5
Breast	HCC1937	8.5
Breast	HCC1954	7.9
Breast	HCC202	8.6
Breast	HCC2157	7.9
Breast	HCC2218	8.3
Breast	HCC38	7.5
Breast	HCC70	7.6
Breast	HDQP1	8.1
Breast	HMC18	6.7
Breast	HS274T	6.9
Breast	HS281T	6.3
Breast	HS343T	6.6
Breast	HS578T	7.3
Breast	HS606T	5.7
Breast	HS739T	6
Breast	HS742T	5.4
Breast	JIMT1	7.9
Breast	KPL1	8.9
Breast	MCF7	8.6
Breast	MDAMB134VI	7.9
Breast	MDAMB157	7.9
Breast	MDAMB175VII	7.6
Breast	MDAMB231	7
Breast	MDAMB361	7
Breast	MDAMB415	8.2
Breast	MDAMB436	7.9
Breast	MDAMB453	8.8
Breast	MDAMB468	7.3
Breast	SKBR3	7.9
Breast	T47D	7.3
Breast	UACC812	8.3
Breast	UACC893	9.8
Breast	YMB1	8.5
Breast	ZR751	8.2
Breast	ZR7530	8.3
Central nervous system	1321N1	7.6
Central nervous system	42MGBA	8.3
Central nervous system	8MGBA	7.3
Central nervous system	A172	6.5
Central nervous system	AM38	6.5
Central nervous system	BECKER	6.5
Central nervous system	CAS1	7.5
Central nervous system	CCFSTTG1	6.6
Central nervous system	D283MED	7.7
Central nervous system	D341MED	6.9
Central nervous system	DAOY	7.9
Central nervous system	DBTRG05MG	6.7
Central nervous system	DKMG	5.9
Central nervous system	GAMG	7.1
Central nervous system	GB1	8.3
Central nervous system	GI1	6.1
Central nervous system	GMS10	7.2
Central nervous system	GOS3	5.3
Central nervous system	H4	7.7
Central nervous system	HS683	6.4
Central nervous system	KALS1	6.8
Central nervous system	KG1C	6.8
Central nervous system	KNS42	4.9
Central nervous system	KNS60	7.8
Central nervous system	KNS81	6.8
Central nervous system	KS1	6.9
Central nervous system	LN18	6.7
Central nervous system	LN229	7.3
Central nervous system	M059K	7.7
Central nervous system	MOGGCCM	7.1
Central nervous system	MOGGUVW	7.9
Central nervous system	NMCG1	7
Central nervous system	ONS76	7.6
Central nervous system	SF126	6.9
Central nervous system	SF295	6.5
Central nervous system	SNB19	6.9
Central nervous system	SNU1105	6.9
Central nervous system	SNU201	6.6
Central nervous system	SNU466	6.4
Central nervous system	SNU489	6.9
Central nervous system	SNU626	6.1
Central nervous system	SNU738	9.6
Central nervous system	SW1088	6.9
Central nervous system	SW1783	6.4
Central nervous system	T98G	7.1
Central nervous system	TM31	7
Central nervous system	U118MG	8
Central nervous system	U138MG	6.8
Central nervous system	U251MG	6.8
Central nervous system	U87MG	6.9
Central nervous system	YH13	6.1
Central nervous system	YKG1	6.9
Endometrium	AN3CA	8.4
Endometrium	COLO684	8.2
Endometrium	EFE184	10.7
Endometrium	EN	8.2
Endometrium	ESS1	7.4
Endometrium	HEC108	10.4
Endometrium	HEC151	7.7
Endometrium	HEC1A	8.2
Endometrium	HEC1B	8.2
Endometrium	HEC251	9.2
Endometrium	HEC265	9.1
Endometrium	HEC50B	9.9
Endometrium	HEC59	9.2
Endometrium	HEC6	8.5
Endometrium	ISHIKAWAHERAKLIO02ER	7.8
Endometrium	JHUEM1	8.6
Endometrium	JHUEM2	7.9
Endometrium	JHUEM3	10
Endometrium	KLE	7.7
Endometrium	MFE280	8.5
Endometrium	MFE296	9.1
Endometrium	MFE319	8.7
Endometrium	RL952	7.7
Endometrium	SNGM	10
Endometrium	SNU1077	9.2
Endometrium	SNU685	8.2
Endometrium	TEN	10.1
Haematopoietic and lymphoid	697	9
Haematopoietic and lymphoid	A3KAW	11
Haematopoietic and lymphoid	A4FUK	9.6
Haematopoietic and lymphoid	ALLSIL	8.7
Haematopoietic and lymphoid	AML193	7
Haematopoietic and lymphoid	AMO1	10.6
Haematopoietic and lymphoid	BCP1	6.9
Haematopoietic and lymphoid	BDCM	5.8
Haematopoietic and lymphoid	BL41	8.5
Haematopoietic and lymphoid	BL70	9
Haematopoietic and lymphoid	BV173	8
Haematopoietic and lymphoid	CA46	8.4
Haematopoietic and lymphoid	CI1	7.8
Haematopoietic and lymphoid	CMK115	10.6
Haematopoietic and lymphoid	CMK86	10.3
Haematopoietic and lymphoid	CMK	9.9
Haematopoietic and lymphoid	CMLT1	7.9
Haematopoietic and lymphoid	COLO775	9.8
Haematopoietic and lymphoid	DAUDI	8.8
Haematopoietic and lymphoid	DB	5.7
Haematopoietic and lymphoid	DEL	6.4
Haematopoietic and lymphoid	DND41	9.3
Haematopoietic and lymphoid	DOHH2	7.5
Haematopoietic and lymphoid	EB1	7.9
Haematopoietic and lymphoid	EB2	6.7
Haematopoietic and lymphoid	EHEB	4.3
Haematopoietic and lymphoid	EJM	5.6
Haematopoietic and lymphoid	EM2	8.1
Haematopoietic and lymphoid	EOL1	7.8
Haematopoietic and lymphoid	F36P	8.6
Haematopoietic and lymphoid	GA10	7.3
Haematopoietic and lymphoid	GDM1	11.7
Haematopoietic and lymphoid	GRANTA519	6.9
Haematopoietic and lymphoid	HDLM2	4.8
Haematopoietic and lymphoid	HDMYZ	7.4
Haematopoietic and lymphoid	HEL9217	11.5
Haematopoietic and lymphoid	HEL	11
Haematopoietic and lymphoid	HH	4.6
Haematopoietic and lymphoid	HL60	7.6
Haematopoietic and lymphoid	HPBALL	8.7
Haematopoietic and lymphoid	HS604T	7.6
Haematopoietic and lymphoid	HS611T	7.2
Haematopoietic and lymphoid	HS616T	6.1
Haematopoietic and lymphoid	HS751T	6.9
Haematopoietic and lymphoid	HT	7
Haematopoietic and lymphoid	HTK	8.2
Haematopoietic and lymphoid	HUNS1	5
Haematopoietic and lymphoid	HUT102	4.9
Haematopoietic and lymphoid	HUT78	8.7
Haematopoietic and lymphoid	JEKO1	9
Haematopoietic and lymphoid	JK1	8.7
Haematopoietic and lymphoid	JM1	9.9
Haematopoietic and lymphoid	JURKAT	8
Haematopoietic and lymphoid	JURLMK1	9
Haematopoietic and lymphoid	JVM2	4.3
Haematopoietic and lymphoid	JVM3	5.5
Haematopoietic and lymphoid	K562	9.8
Haematopoietic and lymphoid	KARPAS299	7.3
Haematopoietic and lymphoid	KARPAS422	4.7
Haematopoietic and lymphoid	KARPAS620	7.4
Haematopoietic and lymphoid	KASUMI1	7
Haematopoietic and lymphoid	KASUMI2	8.1
Haematopoietic and lymphoid	KASUMI6	10.5
Haematopoietic and lymphoid	KCL22	8.8
Haematopoietic and lymphoid	KE37	8.7
Haematopoietic and lymphoid	KE97	6.2
Haematopoietic and lymphoid	KG1	11.6
Haematopoietic and lymphoid	KHM1B	8.4
Haematopoietic and lymphoid	KIJK	6.7
Haematopoietic and lymphoid	KMH2	6.7
Haematopoietic and lymphoid	KMM1	12
Haematopoietic and lymphoid	KMS11	10.7
Haematopoietic and lymphoid	KMS12BM	9.1
Haematopoietic and lymphoid	KMS18	6.8
Haematopoietic and lymphoid	KMS20	6.1
Haematopoietic and lymphoid	KMS21BM	9.3
Haematopoietic and lymphoid	KMS26	9.8
Haematopoietic and lymphoid	KMS27	7.5
Haematopoietic and lymphoid	KMS28BM	9.6
Haematopoietic and lymphoid	KMS34	10
Haematopoietic and lymphoid	KO52	10
Haematopoietic and lymphoid	KOPN8	8.7
Haematopoietic and lymphoid	KU812	9.4
Haematopoietic and lymphoid	KYO1	9.8
Haematopoietic and lymphoid	L1236	6.8
Haematopoietic and lymphoid	L363	6.2
Haematopoietic and lymphoid	L428	5.7
Haematopoietic and lymphoid	L540	6.8
Haematopoietic and lymphoid	LAMA84	8.6
Haematopoietic and lymphoid	LOUCY	11.5
Haematopoietic and lymphoid	LP1	7.6
Haematopoietic and lymphoid	M07E	9.3
Haematopoietic and lymphoid	MC116	6.8
Haematopoietic and lymphoid	ME1	8.1
Haematopoietic and lymphoid	MEC1	6.9
Haematopoietic and lymphoid	MEC2	5.8
Haematopoietic and lymphoid	MEG01	8.8
Haematopoietic and lymphoid	MHHCALL2	8.4
Haematopoietic and lymphoid	MHHCALL3	8.6
Haematopoietic and lymphoid	MHHCALL4	7.6
Haematopoietic and lymphoid	MINO	7.6
Haematopoietic and lymphoid	MJ	5.8
Haematopoietic and lymphoid	MM1S	8.1
Haematopoietic and lymphoid	MOLM13	8.4
Haematopoietic and lymphoid	MOLM16	10.4
Haematopoietic and lymphoid	MOLM6	10
Haematopoietic and lymphoid	MOLP2	5.6
Haematopoietic and lymphoid	MOLP8	11.1
Haematopoietic and lymphoid	MOLT13	10
Haematopoietic and lymphoid	MOLT16	9.1
Haematopoietic and lymphoid	MOLT4	8.5
Haematopoietic and lymphoid	MONOMAC1	7.6
Haematopoietic and lymphoid	MONOMAC6	8.1
Haematopoietic and lymphoid	MOTN1	4.7
Haematopoietic and lymphoid	MUTZ5	7.5
Haematopoietic and lymphoid	MV411	8.6
Haematopoietic and lymphoid	NALM19	7.9
Haematopoietic and lymphoid	NALM1	7.8
Haematopoietic and lymphoid	NALM6	9.4
Haematopoietic and lymphoid	NAMALWA	8.9
Haematopoietic and lymphoid	NB4	10.9
Haematopoietic and lymphoid	NCIH929	7
Haematopoietic and lymphoid	NCO2	8.7
Haematopoietic and lymphoid	NOMO1	7.7
Haematopoietic and lymphoid	NUDHL1	5.5
Haematopoietic and lymphoid	NUDUL1	8.8
Haematopoietic and lymphoid	OCIAML2	7.8
Haematopoietic and lymphoid	OCIAML3	7.2
Haematopoietic and lymphoid	OCIAML5	7.9
Haematopoietic and lymphoid	OCILY10	4.8
Haematopoietic and lymphoid	OCILY19	6.9
Haematopoietic and lymphoid	OCILY3	6.9
Haematopoietic and lymphoid	OCIM1	8.5
Haematopoietic and lymphoid	OPM2	7
Haematopoietic and lymphoid	P12ICHIKAWA	10.2
Haematopoietic and lymphoid	P31FUJ	7.4
Haematopoietic and lymphoid	P3HR1	7.4
Haematopoietic and lymphoid	PCM6	4.6
Haematopoietic and lymphoid	PEER	10.2
Haematopoietic and lymphoid	PF382	9.3
Haematopoietic and lymphoid	PFEIFFER	8.5
Haematopoietic and lymphoid	PL21	6.3
Haematopoietic and lymphoid	RAJI	7.5
Haematopoietic and lymphoid	RCHACV	8.4
Haematopoietic and lymphoid	REC1	7.1
Haematopoietic and lymphoid	REH	8.4
Haematopoietic and lymphoid	RI1	7.9
Haematopoietic and lymphoid	RL	6.9
Haematopoietic and lymphoid	RPMI8226	7.3
Haematopoietic and lymphoid	RPMI8402	11.2
Haematopoietic and lymphoid	RS411	7.9
Haematopoietic and lymphoid	SEM	8.3
Haematopoietic and lymphoid	SET2	9.8
Haematopoietic and lymphoid	SIGM5	8.1
Haematopoietic and lymphoid	SKM1	8.6
Haematopoietic and lymphoid	SKMM2	7.5
Haematopoietic and lymphoid	SR786	8.2
Haematopoietic and lymphoid	ST486	9.1
Haematopoietic and lymphoid	SUDHL10	5.3
Haematopoietic and lymphoid	SUDHL1	6.8
Haematopoietic and lymphoid	SUDHL4	7.4
Haematopoietic and lymphoid	SUDHL5	8
Haematopoietic and lymphoid	SUDHL6	7.6
Haematopoietic and lymphoid	SUDHL8	8.3
Haematopoietic and lymphoid	SUPB15	7.2
Haematopoietic and lymphoid	SUPHD1	4.8
Haematopoietic and lymphoid	SUPM2	6.4
Haematopoietic and lymphoid	SUPT11	9.2
Haematopoietic and lymphoid	SUPT1	7.5
Haematopoietic and lymphoid	TALL1	10.1
Haematopoietic and lymphoid	TF1	10.5
Haematopoietic and lymphoid	THP1	7
Haematopoietic and lymphoid	TO175T	6.7
Haematopoietic and lymphoid	TOLEDO	9.8
Haematopoietic and lymphoid	U266B1	7.5
Haematopoietic and lymphoid	U937	7.8
Haematopoietic and lymphoid	UT7	8.8
Haematopoietic and lymphoid	WSUDLCL2	5.4
Kidney	769P	8
Kidney	786O	7.5
Kidney	A498	10
Kidney	A704	9.4
Kidney	ACHN	8.1
Kidney	BFTC909	9.6
Kidney	CAKI1	9.8
Kidney	CAKI2	10.8
Kidney	CAL54	6.8
Kidney	KMRC1	8.6
Kidney	KMRC20	8.8
Kidney	KMRC2	9.3
Kidney	KMRC3	9
Kidney	OSRC2	8.1
Kidney	RCC10RGB	7.2
Kidney	SNU1272	9
Kidney	SNU349	7.4
Kidney	TUHR10TKB	8.9
Kidney	TUHR14TKB	6.8
Kidney	TUHR4TKB	7.7
Kidney	VMRCRCW	8.8
Kidney	VMRCRCZ	8.6
Large intestine	C2BBE1	10.7
Large intestine	CCK81	7.6
Large intestine	CL11	6.4
Large intestine	CL14	7.4
Large intestine	CL34	6.2
Large intestine	CL40	5.8
Large intestine	COLO205	4.6
Large intestine	COLO320	8.5
Large intestine	COLO678	7.4
Large intestine	CW2	7
Large intestine	DLD1	6.2
Large intestine	GP2D	8
Large intestine	HCC56	6
Large intestine	HCT116	8.9
Large intestine	HCT15	7.3
Large intestine	HS675T	5.7
Large intestine	HS698T	6.8
Large intestine	HT115	5.8
Large intestine	HT29	6.9
Large intestine	HT55	7.6
Large intestine	KM12	7.4
Large intestine	LOVO	7.2
Large intestine	LS1034	6
Large intestine	LS123	7.6
Large intestine	LS180	7.2
Large intestine	LS411N	7.3
Large intestine	LS513	4.8
Large intestine	MDST8	7.7
Large intestine	NCIH508	6.2
Large intestine	NCIH716	6.4
Large intestine	NCIH747	6.7
Large intestine	OUMS23	10.8
Large intestine	RCM1	7
Large intestine	RKO	7.6
Large intestine	SKCO1	7
Large intestine	SNU1040	8.3
Large intestine	SNU1197	6
Large intestine	SNU175	7.4
Large intestine	SNU283	6.3
Large intestine	SNU407	7.9
Large intestine	SNU503	7.2
Large intestine	SNU61	6.5
Large intestine	SNU81	8.3
Large intestine	SNUC1	6.5
Large intestine	SNUC2A	6.8
Large intestine	SNUC4	7
Large intestine	SNUC5	7.8
Large intestine	SW1116	6.1
Large intestine	SW1417	7.5
Large intestine	SW1463	7.5
Large intestine	SW403	6.2
Large intestine	SW480	7.5
Large intestine	SW48	7.8
Large intestine	SW620	8.1
Large intestine	SW837	8.8
Large intestine	SW948	6.6
Large intestine	T84	7.3
Liver	ALEXANDERCELLS	7.8
Liver	C3A	8
Liver	HEP3B217	9.6
Liver	HEPG2	7.9
Liver	HLE	7.9
Liver	HLF	8.4
Liver	HUH1	7.3
Liver	HUH6	11
Liver	HUH7	9.7
Liver	JHH1	8.2
Liver	JHH2	6.7
Liver	JHH4	7.9
Liver	JHH5	7.9
Liver	JHH6	8.4
Liver	JHH7	8.3
Liver	LI7	6.9
Liver	PLCPRF5	8.4
Liver	SKHEP1	6.5
Liver	SNU182	7.1
Liver	SNU387	7.2
Liver	SNU398	9.5
Liver	SNU423	6.6
Liver	SNU449	8.2
Liver	SNU475	8.3
Liver	SNU761	7.2
Liver	SNU878	6.9
Liver	SNU886	7.5
Lung	A549	8.8
Lung	ABC1	8
Lung	BEN	9
Lung	CAL12T	8.2
Lung	CALU1	7
Lung	CALU3	8.2
Lung	CALU6	6.1
Lung	CHAGOK1	7.5
Lung	COLO668	8.5
Lung	COLO699	6.8
Lung	CORL105	6.1
Lung	CORL23	9.2
Lung	CORL24	7.2
Lung	CORL279	8.8
Lung	CORL311	7.6
Lung	CORL47	9.1
Lung	CORL51	8.7
Lung	CORL88	8.7
Lung	CORL95	8.6
Lung	CPCN	7.4
Lung	DMS114	8.6
Lung	DMS153	9.9
Lung	DMS273	6.8
Lung	DMS454	8.1
Lung	DMS53	8.1
Lung	DMS79	8.5
Lung	DV90	7.3
Lung	EBC1	7
Lung	EPLC272H	7.3
Lung	HARA	6.8
Lung	HCC1171	8.4
Lung	HCC1195	8.9
Lung	HCC15	7.4
Lung	HCC2279	7.8
Lung	HCC2935	6.8
Lung	HCC33	7.9
Lung	HCC366	6.7
Lung	HCC4006	6.7
Lung	HCC44	5.7
Lung	HCC78	8
Lung	HCC827	8.2
Lung	HCC95	7.8
Lung	HLC1	7.5
Lung	HLFA	6
Lung	HS229T	6.7
Lung	HS618T	7
Lung	IALM	8
Lung	KNS62	7.5
Lung	LC1F	7.9
Lung	LC1SQSF	7.8
Lung	LCLC103H	8.7
Lung	LCLC97TM1	8
Lung	LK2	7.5
Lung	LOUNH91	6.9
Lung	LU65	5.6
Lung	LU99	7.2
Lung	LUDLU1	8.1
Lung	LXF289	6.9
Lung	MORCPR	8.2
Lung	NCIH1048	8.6
Lung	NCIH1092	7.8
Lung	NCIH1105	8.9
Lung	NCIH1155	7.3
Lung	NCIH1184	7.8
Lung	NCIH1299	7.6
Lung	NCIH1339	7.9
Lung	NCIH1341	7.6
Lung	NCIH1355	9.3
Lung	NCIH1373	7.3
Lung	NCIH1385	8.6
Lung	NCIH1395	7.4
Lung	NCIH1435	7.5
Lung	NCIH1436	6.9
Lung	NCIH1437	8.3
Lung	NCIH146	9.7
Lung	NCIH1563	6.8
Lung	NCIH1568	8.6
Lung	NCIH1573	7.1
Lung	NCIH1581	9.4
Lung	NCIH1618	8.1
Lung	NCIH1623	7.5
Lung	NCIH1648	8
Lung	NCIH1650	8.3
Lung	NCIH1651	8.2
Lung	NCIH1666	6.9
Lung	NCIH1693	7.1
Lung	NCIH1694	6.5
Lung	NCIH1703	7.7
Lung	NCIH1734	8.3
Lung	NCIH1755	6.7
Lung	NCIH1781	9.1
Lung	NCIH1792	8.3
Lung	NCIH1793	8.6
Lung	NCIH1836	7.6
Lung	NCIH1838	7.5
Lung	NCIH1869	7.3
Lung	NCIH1876	6.9
Lung	NCIH1915	8.1
Lung	NCIH1930	9
Lung	NCIH1944	8.6
Lung	NCIH1963	6.9
Lung	NCIH196	7.6
Lung	NCIH1975	7.8
Lung	NCIH2009	8
Lung	NCIH2023	9
Lung	NCIH2029	9.3
Lung	NCIH2030	7.3
Lung	NCIH2066	8
Lung	NCIH2081	9.8
Lung	NCIH2085	7.6
Lung	NCIH2087	8.3
Lung	NCIH209	8.5
Lung	NCIH2106	8
Lung	NCIH2110	8.4
Lung	NCIH211	8.1
Lung	NCIH2122	6.9
Lung	NCIH2126	8
Lung	NCIH2141	8.3
Lung	NCIH2170	8.3
Lung	NCIH2171	8.3
Lung	NCIH2172	8.6
Lung	NCIH2196	7.6
Lung	NCIH2227	8.5
Lung	NCIH2228	7.6
Lung	NCIH226	6.4
Lung	NCIH2286	7.4
Lung	NCIH2291	7.6
Lung	NCIH2342	9.4
Lung	NCIH2347	8.1
Lung	NCIH23	7.7
Lung	NCIH2405	7.1
Lung	NCIH2444	8.2
Lung	NCIH292	7.7
Lung	NCIH322	9.1
Lung	NCIH3255	8
Lung	NCIH358	8
Lung	NCIH441	8.4
Lung	NCIH446	8
Lung	NCIH460	6.7
Lung	NCIH510	9.8
Lung	NCIH520	8.3
Lung	NCIH522	7.4
Lung	NCIH524	7.9
Lung	NCIH526	7.1
Lung	NCIH596	6.8
Lung	NCIH647	7.1
Lung	NCIH650	6.8
Lung	NCIH661	9.1
Lung	NCIH69	9
Lung	NCIH727	8
Lung	NCIH810	8.2
Lung	NCIH82	8
Lung	NCIH838	9.2
Lung	NCIH841	8.2
Lung	NCIH854	7.1
Lung	NCIH889	8.4
Lung	PC14	7
Lung	RERFLCAD1	6
Lung	RERFLCAD2	7.2
Lung	RERFLCAI	7.6
Lung	RERFLCKJ	6.8
Lung	RERFLCMS	6.7
Lung	RERFLCSQ1	7.6
Lung	SBC5	7.8
Lung	SCLC21H	8.3
Lung	SHP77	8.4
Lung	SKLU1	7.2
Lung	SKMES1	6.8
Lung	SQ1	7.3
Lung	SW1271	6.7
Lung	SW1573	6.5
Lung	SW900	6.9
Lung	VMRCLCD	9.5
Lung	VMRCLCP	8.1
Oesophagus	COLO680N	9
Oesophagus	ECGI10	8.9
Oesophagus	KYSE140	7.9
Oesophagus	KYSE150	7.6
Oesophagus	KYSE180	8
Oesophagus	KYSE270	8.7
Oesophagus	KYSE30	7.5
Oesophagus	KYSE410	7
Oesophagus	KYSE450	6.8
Oesophagus	KYSE510	9.2
Oesophagus	KYSE520	7.5
Oesophagus	KYSE70	6.4
Oesophagus	OE19	7.9
Oesophagus	OE33	8.2
Oesophagus	TE10	8.1
Oesophagus	TE11	8.2
Oesophagus	TE14	7.7
Oesophagus	TE15	8.5
Oesophagus	TE1	7.7
Oesophagus	TE4	7.8
Oesophagus	TE5	8.3
Oesophagus	TE6	9.4
Oesophagus	TE8	8.6
Oesophagus	TE9	8.4
Oesophagus	TT	7.6
Ovary	59M	9.7
Ovary	A2780	9.6
Ovary	CAOV3	6.2
Ovary	CAOV4	7.7
Ovary	COLO704	7.7
Ovary	COV318	7.4
Ovary	COV362	7.7
Ovary	COV434	7.8
Ovary	COV504	6.5
Ovary	COV644	5.7
Ovary	EFO21	9.5
Ovary	EFO27	8.2
Ovary	ES2	6.3
Ovary	FUOV1	8.1
Ovary	HEYA8	6.9
Ovary	HS571T	6
Ovary	IGROV1	9.4
Ovary	JHOC5	10.7
Ovary	JHOM1	11
Ovary	JHOM2B	7.1
Ovary	JHOS2	7.5
Ovary	JHOS4	7.7
Ovary	KURAMOCHI	7.1
Ovary	MCAS	5.6
Ovary	NIHOVCAR3	8.7
Ovary	OAW28	7.4
Ovary	OAW42	7.8
Ovary	OC314	7.6
Ovary	OC316	7.5
Ovary	ONCODG1	9.1
Ovary	OV56	9.5
Ovary	OV7	7
Ovary	OV90	9.5
Ovary	OVCAR4	8.7
Ovary	OVCAR8	7.5
Ovary	OVISE	9.5
Ovary	OVK18	7.9
Ovary	OVKATE	8.1
Ovary	OVMANA	8.9
Ovary	OVSAHO	7.8
Ovary	OVTOKO	9.9
Ovary	RMGI	9
Ovary	RMUGS	8.7
Ovary	SKOV3	9.2
Ovary	SNU119	9
Ovary	SNU840	8
Ovary	SNU8	8
Ovary	TOV112D	9
Ovary	TOV21G	9.8
Ovary	TYKNU	7.1
Pancreas	ASPC1	4.7
Pancreas	BXPC3	7.2
Pancreas	CAPAN1	7.6
Pancreas	CAPAN2	6.9
Pancreas	CFPAC1	7.9
Pancreas	DANG	8.5
Pancreas	HPAC	7.7
Pancreas	HPAFII	6.3
Pancreas	HS766T	5.4
Pancreas	HUPT3	7.5
Pancreas	HUPT4	6.3
Pancreas	KCIMOH1	5.9
Pancreas	KLM1	9.3
Pancreas	KP2	7.4
Pancreas	KP3	4.7
Pancreas	KP4	7.4
Pancreas	L33	8.8
Pancreas	MIAPACA2	8.2
Pancreas	PANC0203	7.4
Pancreas	PANC0213	7.7
Pancreas	PANC0327	7.3
Pancreas	PANC0403	7.8
Pancreas	PANC0504	6.5
Pancreas	PANC0813	7.7
Pancreas	PANC1005	7.6
Pancreas	PANC1	6.4
Pancreas	PATU8902	6.4
Pancreas	PATU8988S	6.6
Pancreas	PATU8988T	7.5
Pancreas	PK1	8.4
Pancreas	PK45H	6.3
Pancreas	PK59	6.6
Pancreas	PL45	6.4
Pancreas	PSN1	7.6
Pancreas	QGP1	9.2
Pancreas	SNU213	7.6
Pancreas	SNU324	5.9
Pancreas	SNU410	6.4
Pancreas	SU8686	8.6
Pancreas	SUIT2	6.7
Pancreas	SW1990	7.7
Pancreas	T3M4	7.8
Pancreas	TCCPAN2	6.1
Pancreas	YAPC	7.4
Pleura	ACCMESO1	7.8
Pleura	DM3	6
Pleura	ISTMES1	7.2
Pleura	ISTMES2	6.9
Pleura	JL1	6.4
Pleura	MPP89	7.3
Pleura	MSTO211H	6.6
Pleura	NCIH2052	7.2
Pleura	NCIH2452	6.8
Pleura	NCIH28	7
Prostate	22RV1	7.8
Prostate	DU145	6.7
Prostate	LNCAPCLONEFGC	7.3
Prostate	MDAPCA2B	7
Prostate	NCIH660	8
Prostate	PC3	6.8
Prostate	VCAP	7.8
Salivary gland	A253	7.7
Salivary gland	YD15	7.2
Skin	A101D	6.9
Skin	A2058	7.1
Skin	A375	6.9
Skin	C32	5
Skin	CHL1	7.6
Skin	CJM	7
Skin	COLO679	6.3
Skin	COLO741	7.1
Skin	COLO783	7.9
Skin	COLO792	6.9
Skin	COLO800	8.1
Skin	COLO818	6.6
Skin	COLO829	6.4
Skin	COLO849	7.5
Skin	G361	6.4
Skin	GRM	7.9
Skin	HMCB	7.7
Skin	HS294T	6.9
Skin	HS600T	5.7
Skin	HS688AT	6
Skin	HS695T	6.6
Skin	HS839T	6.2
Skin	HS852T	6
Skin	HS895T	6.5
Skin	HS934T	6.5
Skin	HS936T	5.9
Skin	HS939T	5.9
Skin	HS940T	7
Skin	HS944T	6.7
Skin	HT144	6.7
Skin	IGR1	6.1
Skin	IGR37	6.7
Skin	IGR39	7.7
Skin	IPC298	6.5
Skin	K029AX	6.6
Skin	LOXIMVI	7.7
Skin	MALME3M	5.5
Skin	MDAMB435S	6.7
Skin	MELHO	6.6
Skin	MELJUSO	6.7
Skin	MEWO	5.9
Skin	RPMI7951	7
Skin	RVH421	7.2
Skin	SH4	6.2
Skin	SKMEL1	6.5
Skin	SKMEL24	5.4
Skin	SKMEL28	6.4
Skin	SKMEL2	6.5
Skin	SKMEL30	7
Skin	SKMEL31	6.2
Skin	SKMEL3	7
Skin	SKMEL5	6.3
Skin	UACC257	6.8
Skin	UACC62	7.6
Skin	WM115	5.5
Skin	WM1799	6.9
Skin	WM2664	7.4
Skin	WM793	7.6
Skin	WM88	6.6
Skin	WM983B	7.2
Small intestine	HUTU80	8.5
Soft tissue	A204	7.6
Soft tissue	G401	10.1
Soft tissue	G402	9.2
Soft tissue	GCT	6.9
Soft tissue	HS729	7
Soft tissue	HT1080	7.2
Soft tissue	KYM1	9.3
Soft tissue	MESSA	7.8
Soft tissue	RD	7.1
Soft tissue	RH30	8.1
Soft tissue	RH41	9.7
Soft tissue	RKN	7.4
Soft tissue	S117	8.7
Soft tissue	SJRH30	9.2
Soft tissue	SKLMS1	7.2
Soft tissue	SKUT1	8.6
Soft tissue	TE125T	6.3
Soft tissue	TE159T	5.8
Soft tissue	TE441T	10.5
Soft tissue	TE617T	7.4
Stomach	2313287	6.7
Stomach	AGS	9.7
Stomach	AZ521	8.9
Stomach	ECC10	8.8
Stomach	ECC12	7.8
Stomach	FU97	9.4
Stomach	GCIY	8.5
Stomach	GSS	9.9
Stomach	GSU	4.8
Stomach	HGC27	9.4
Stomach	HS746T	7.7
Stomach	HUG1N	6.2
Stomach	IM95	6
Stomach	KATOIII	8.1
Stomach	KE39	7.9
Stomach	LMSU	7.3
Stomach	MKN1	7.9
Stomach	MKN45	8.8
Stomach	MKN74	8
Stomach	MKN7	7.9
Stomach	NCCSTCK140	10
Stomach	NCIN87	6.7
Stomach	NUGC2	7.9
Stomach	NUGC3	7.9
Stomach	NUGC4	5.8
Stomach	OCUM1	5.3
Stomach	RERFGC1B	10.3
Stomach	SH10TC	8.4
Stomach	SNU16	6.2
Stomach	SNU1	10.5
Stomach	SNU216	7.7
Stomach	SNU520	4.6
Stomach	SNU5	5.4
Stomach	SNU601	8.9
Stomach	SNU620	7.7
Stomach	SNU668	8.3
Stomach	SNU719	7.3
Stomach	TGBC11TKB	7.8
Thyroid	8305C	8
Thyroid	8505C	6.8
Thyroid	BCPAP	7.5
Thyroid	BHT101	6.4
Thyroid	CAL62	7
Thyroid	CGTHW1	7.3
Thyroid	FTC133	7.8
Thyroid	FTC238	8.4
Thyroid	ML1	7.3
Thyroid	SW579	7.8
Thyroid	TT2609C02	6.3
Thyroid	TT	8.1
Upper aerodigestive tract	BHY	9.2
Upper aerodigestive tract	BICR16	6.9
Upper aerodigestive tract	BICR18	8.5
Upper aerodigestive tract	BICR22	7.3
Upper aerodigestive tract	BICR31	7.4
Upper aerodigestive tract	BICR56	8.3
Upper aerodigestive tract	BICR6	8.3
Upper aerodigestive tract	CAL27	6.2
Upper aerodigestive tract	CAL33	7.7
Upper aerodigestive tract	DETROIT562	6.8
Upper aerodigestive tract	FADU	7.9
Upper aerodigestive tract	HS840T	6.8
Upper aerodigestive tract	HSC2	6.7
Upper aerodigestive tract	HSC3	7.9
Upper aerodigestive tract	HSC4	8.2
Upper aerodigestive tract	PECAPJ15	7.8
Upper aerodigestive tract	PECAPJ34CLONEC12	8
Upper aerodigestive tract	PECAPJ41CLONED2	7.4
Upper aerodigestive tract	PECAPJ49	8.4
Upper aerodigestive tract	SCC15	6.8
Upper aerodigestive tract	SCC25	8.1
Upper aerodigestive tract	SCC4	7.2
Upper aerodigestive tract	SCC9	7.3
Upper aerodigestive tract	SNU1076	6.9
Upper aerodigestive tract	SNU1214	6.8
Upper aerodigestive tract	SNU46	7.4
Upper aerodigestive tract	SNU899	8.2
Upper aerodigestive tract	YD10B	7.8
Upper aerodigestive tract	YD38	9
Upper aerodigestive tract	YD8	8.3
Urinary tract	5637	6.9
Urinary tract	639V	7.6
Urinary tract	647V	7.9
Urinary tract	BC3C	10.2
Urinary tract	BFTC905	7.7
Urinary tract	CAL29	8.4
Urinary tract	HS172T	6.5
Urinary tract	HT1197	7.7
Urinary tract	HT1376	6.4
Urinary tract	J82	7
Urinary tract	JMSU1	7.9
Urinary tract	KMBC2	8.7
Urinary tract	KU1919	8.4
Urinary tract	RT11284	7.5
Urinary tract	RT112	8.6
Urinary tract	RT4	7.3
Urinary tract	SCABER	7.9
Urinary tract	SW1710	9.3
Urinary tract	SW780	8.4
Urinary tract	T24	7.3
Urinary tract	TCCSUP	7
Urinary tract	UMUC1	8.5
Urinary tract	UMUC3	7.6
Urinary tract	VMCUB1	8.3

> The Human Protein Atlas (HPA)

[ TOP ]

Tissue	Expression Level (TPM)
Adipose tissue	0.8
Adrenal gland	0.7
Appendix	1.2
Bone marrow	2.3
Breast	1.7
Cerebral cortex	0.9
Cervix, uterine	0.8
Colon	0.7
Duodenum	0.8
Endometrium	1.7
Epididymis	3.7
Esophagus	0.4
Fallopian tube	1.2
Gallbladder	1.3
Heart muscle	0.4
Kidney	1.1
Liver	0.3
Lung	1.1
Lymph node	1.1
Ovary	0.7
Pancreas	0.8
Parathyroid gland	2.7
Placenta	2.9
Prostate	0.8
Rectum	0.8
Salivary gland	0.5
Seminal vesicle	0.9
Skeletal muscle	0.1
Skin	4.5
Small intestine	0.9
Smooth muscle	1.3
Spleen	0.9
Stomach	0.9
Testis	9.2
Thyroid gland	2.8
Tonsil	0.8
Urinary bladder	1.3

> Text Mining based Expression

[ TOP ]

PMID	Expression	Cancer	Evidence
27666771	Overexpression	Colorectal Carcinoma	Significant upregulation of DNMT1, DNMT3A, and DNMT3B expression was found in para-carcinoma tissues, compared with the histopathologically unchanged tissues (P<0.05)
28220037	Overexpression	Endometrial Carcinoma	There were a 61.7% (95/154) overexpression of DNMT3B, 50.0% (77/154) loss of PTEN expression and 18.2% (28/154) loss of hMLH1 expression. DNMT3B expression was statistically significant based on the grade of endometrial carcinomas (p=0.031).
11146446	Overexpression	Colorectal Carcinoma; Gastric Carcinoma	The average level of mRNA for DNMT1 and DNMT3b in colorectal and stomach cancers was significantly higher than in corresponding non-cancerous mucosae, whereas the average level of mRNA for DNMT2 was significantly lower in colorectal and stomach cancers than in non-cancerous tissue.
11230735	Overexpression	Hepatocellular Carcinoma	Significant overexpression of DNMT3b and reduced expression of DNMT2 were observed in HCCs compared with the corresponding noncancerous liver tissues.
12594811	Overexpression	Transitional Cell Carcinoma	DNMT3B overexpression was observed in about half of all high-stage TCC (DNMT3B vs. tumor stage, chi(2): p = 0.03), whereas overexpression of DNMT3A was rarer and less pronounced.
14555514	Overexpression	Sporadic Breast Carcinoma	DNMT3B was overexpressed in 30% of the patients (5.4 and 3.1% for DNMT1 and DNMT3A, respectively).
15661247	Overexpression	Ovarian Endometrioid Adenocarcinoma	The results suggest that DNMT3B overexpression may play a significant role in endometrial cancer development.
15721400	Overexpression	Ovarian Endometrioid Adenocarcinoma	While DNMT2 and DNMT3A expression appear to be normal, two- to fourfold increase in DNMT1 and DNMT3B were found in both Grade I and Grade III endometrioid cancers.
15885882	Overexpression	Hepatocellular Carcinoma	Expression of DNMT1, DNMT3a and DNMT3b mRNA was detected in 33.3, 59.3, and 55.6% of HCCs and 40.7, 22.2, and 0% of non-neoplastic liver tissues, respectively.
16888795	Overexpression	Non-Small Cell Lung Carcinoma	The mRNA levels of DNMT1 and DNMT3b were elevated in 53% and 58% of 102 NSCLCs, respectively.
17017004	Overexpression	Esophageal Squamous Cell Carcinoma	All DNMTs were constitutively expressed in the normal oesophageal mucosa but a significantly higher expression of DNMT3B was observed in the tumours.
17071074	Overexpression	Sporadic Breast Carcinoma	Pairwise analyses of gene expression patterns showed that 28/32 tumours lacked BRCA1 expression and also exhibited cytoplasmic CTCF staining, while 24/32 of these tumours also overexpressed DNMT3b.
17140695	Overexpression	Lung Carcinoma	By immunohistochemical analysis, we demonstrated that DNMT1, DNMT3a and DNMT3b proteins were highly expressed in a coordinate manner in lung tumors, particularly in smokers (P=0.037, by the Fisher exact test).
17998942	Overexpression	Breast Carcinoma	Directed by microarray analyses, we report that autocrine human growth hormone (hGH) increased the mRNA and protein expression of DNA methyltransferase 1 (DNMT1), DNMT3A and DNMT3B in mammary carcinoma cells.
18221536	Overexpression	Breast Carcinoma	DNMT3b overexpression contributes to a hypermethylator phenotype in human breast cancer cell lines.
18253830	Overexpression	Gastric Carcinoma	We discovered that the positive rates of DNMT1, DNMT3a, and DNMT3b expression in GC tissues were 81.6%, 81.6%, and 68.4%, respectively, and they were significantly higher than those of both para-cancerous (39.5%, 50%, and 44.7%) and normal tissues (10.5%, 10.5%, and 7.9%).
18414412	Overexpression	Head and Neck Squamous Cell Carcinoma	However, the high level of DNMT3b expression was significantly associated with poor prognosis only in young patients (<65 years).
18637271	Overexpression	Prostate Carcinoma	SIRT1 and DNMT3B were overexpressed in cancerous over benign tissues, whereas BMI-1 was rather downregulated and DNMT1 significantly diminished.
19470733	Overexpression	Colorectal Carcinoma	Tumoral DNMT3B overexpression was significantly associated with CIMP-high [> or =6/8 methylated CIMP-specific promoters; odds ratio (OR), 3.34; 95% confidence interval, 2.11-5.29; P < 0.0001].
20127025	Overexpression	Gastric Carcinoma	These results demonstrate that DNMT3B overexpression is related to late phase invasion (P=0.029) and intestinal type (P=0.012) in GC.
20398054	Overexpression	Diffuse Large B-Cell Lymphoma	DNA methyltransferase DNMT3b protein overexpression as a prognostic factor in patients with diffuse large B-cell lymphomas.
21068132	Overexpression	Colorectal Neoplasm	DNMT3B levels of immunohistochemical expression increased significantly (p < 0.001) from normal to hyperplastic and from adenomatous polyps to carcinoma samples.
21458988	Overexpression	Gastric Carcinoma	High DNMT1 and DNMT3b expression was found in 105/127 (83%) and 79/127 (62%) carcinomas, respectively.
21887463	Overexpression	Cervical Carcinoma	Our result showed significantly higher levels of CXCR4, DNMT3A, DNMT3B and DNMT1 transcript (p=0.0058, 0.0163, 0.0003 and <0.0001, respectively) levels in cancer tissue as compared to normal samples.
21887466	Overexpression	Gastric Carcinoma	Overexpression of DNMT1, DNMT3A and DNMT3B in gastric cancer tissues was observed in 35 (64.8%), 38 (70.4%) and 28 (51.9%) of 54 cases, respectively.
21909138	Overexpression	Hepatocellular Carcinoma	DNMT3B overexpression was detected in 81.25% of clinical HCC specimens and was negatively associated with MTSS1 in HCC cells and clinical samples.
22244828	Overexpression	Colorectal Carcinoma	Forced DNMT3B overexpression in cancer cells restored the methylation levels of these promoters in the healthy colon.
22301400	Overexpression	Pancreatic Ductal Adenocarcinoma	Patients with higher levels of DNMT1, DNMT3A and/or DNMT3B expression had an overall lower survival than those with lower levels of expression.
22330137	Overexpression	Cervical Carcinoma	Here, we report evidence of the overexpression of DNA methyltransferases 3B (DNMT3B) in invasive cervical cancer and of the inhibition of metastasis by DNMT3B interference.
22394436	Overexpression	Testicular Seminoma	Patients with seminomas showing focal DNMT3B expression are at increased risk of relapse, and should be followed up carefully.
22919364	Overexpression	Pancreatic Carcinoma	DNMT3B overexpression in tumor tissue was positively correlated with both lymph nodes spreading (P = 0.046) and resection margin status (P = 0.04), and a borderline association with perineural invasion (P = 0.06) was found.
23307264	Overexpression	Rectal Neoplasm	The DNMT3b expression in neoplastic rectal epithelium (0.76, range 0.59-0.84) was increased compared to that observed in non-neoplastic epithelium (0.32, range 0.18-0.67, P < 0.001).
23420051	Overexpression	Ovarian Carcinoma	The results indicated that the mRNA expression of DNMT1, DNMT3b and class I HDACs was increased in ovarian cancers, while the expression of DNMT3a was not different between cancer tissues and normal ovaries.
24548441	Overexpression	Lung Carcinoma	The protein expressions of DNMT1, DNMT3a and DNMT3b in patients with lung cancer (15 ± 10, 997 ± 76 , 302 ± 25) were higher than those of the controls (13 ± 10, 344 ± 93, 108 ± 22).
24625449	Overexpression	Lip and Oral Cavity Carcinoma	Activated IL-6 signaling might be responsible to the induction of DNMT3b overexpression on oral cancer.
25009393	Overexpression	Gastric Carcinoma	Expression of DNMT1, DNMT3a and DNMT3b in gastric cancer was significantly higher compared to that in the paired control samples (60.0% vs 37.6%, 61.2% vs 4.7%, and 94.1% vs 71.8%, P < 0.01).
25122426	Overexpression	Lung Carcinoma	DNMT3B overexpression by deregulation of FOXO3a-mediated transcription repression and MDM2 overexpression in lung cancer.
25204569	Overexpression	Acute Myeloid Leukemia	In multivariable analyses, high DNMT3B expression remained an independent predictor of lower CR rates (P=0.04) and shorter DFS (P=0.04) and OS (P=0.001).
25550796	Overexpression	Renal Cell Carcinoma	DNMT1, DNMT3A and DNMT3B proteins were highly expressed in clear cell RCC, papillary RCC and chromophobe RCC tissues than that of no-tumor tissues (all P < 0.05).
25938433	Overexpression	Prostate Carcinoma	Relatively higher expression of DNA methyl-transferases (DNMT1 and DNMT3b) and HIF-1α genes (34-50%, P<0.05) were also detected in tumor tissues.
26305882	Overexpression	Colorectal Carcinoma	DNMT1, DNMT3B, and EZH2 were expressed at significantly higher levels in tumor vs. normal tissues.
27317771	Underexpression	Bladder Carcinoma	Consistent with this, ANG-MMP2 overexpression and DNMT3b underexpression correlated with reduction in disease free survival of human bladder cancer patients.
27543768	Overexpression	Medulloblastoma	Elevated expression of DNMT1, DNMT3A and DNMT3B was observed in 63.64%, 68.18% and 72.73% of all cases, respectively.
27764816	Overexpression	Rhabdomyosarcoma	Our study show for the first time a significant up-regulation of DNMT3B levels in 14 RMS tumour samples and 4 RMS cell lines in comparison to normal skeletal muscle.

Summary
Symbol	DNMT3B
Name	DNA methyltransferase 3 beta
Aliases	ICF; ICF1; M.HsaIIIB; DNA MTase HsaIIIB; DNA methyltransferase HsaIIIB; DNA (cytosine-5)-methyltransferase 3 ......
Location	20q11.21
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Somatic copy number alteration in primary tomur tissue

> The Cancer Genome Atlas (TCGA)

[ TOP ]

Correlation between expression and SCNA as well as percentage of patients in different status.

Cancer	Full Name	# Sample	R	P	% Loss	% Neutral	% Gain	Status
BLCA	Bladder urothelial carcinoma	404	0.443	8.2e-21	0.7	36.4	62.9	Gain
BRCA	Breast invasive carcinoma	1075	0.307	5.69e-25	5.6	53.2	41.2	Gain
CESC	Cervical and endocervical cancers	292	0.25	1.55e-05	1.7	53.8	44.5	Gain
COAD	Colon adenocarcinoma	449	0.442	6.25e-23	0.2	28.5	71.3	Gain
ESCA	Esophageal carcinoma	183	0.208	0.00479	1.6	30.6	67.8	Gain
GBM	Glioblastoma multiforme	147	0.336	3.19e-05	2	61.9	36.1	Gain
HNSC	Head and Neck squamous cell carcinoma	514	0.167	0.000145	2.3	53.5	44.2	Gain
KIRC	Kidney renal clear cell carcinoma	525	0.237	3.72e-08	0	77.5	22.5	Neutral
KIRP	Kidney renal papillary cell carcinoma	288	0.14	0.0173	0	64.9	35.1	Gain
LAML	Acute Myeloid Leukemia	166	0.055	0.478	0.6	98.2	1.2	Neutral
LGG	Brain Lower Grade Glioma	513	0.197	6.85e-06	0.4	91	8.6	Neutral
LIHC	Liver hepatocellular carcinoma	364	0.315	8.41e-10	2.5	67	30.5	Neutral
LUAD	Lung adenocarcinoma	512	0.349	4.15e-16	10.9	47.1	42	Gain
LUSC	Lung squamous cell carcinoma	498	0.454	1.02e-26	4.4	37.3	58.2	Gain
OV	Ovarian serous cystadenocarcinoma	300	0.41	1.45e-13	2.7	37	60.3	Gain
PAAD	Pancreatic adenocarcinoma	177	0.168	0.0257	2.3	74.6	23.2	Neutral
PCPG	Pheochromocytoma and Paraganglioma	162	0.123	0.119	1.2	92.6	6.2	Neutral
PRAD	Prostate adenocarcinoma	491	0.342	5.94e-15	2.4	90.8	6.7	Neutral
READ	Rectum adenocarcinoma	164	0.43	9.29e-09	0	11.6	88.4	Gain
SARC	Sarcoma	255	0.327	9.13e-08	5.5	56.9	37.6	Gain
SKCM	Skin Cutaneous Melanoma	367	0.348	6.99e-12	1.6	49.6	48.8	Gain
STAD	Stomach adenocarcinoma	413	0.551	3.7e-34	1.2	36.8	62	Gain
TGCT	Testicular Germ Cell Tumors	150	0.116	0.157	7.3	62.7	30	Neutral
THCA	Thyroid carcinoma	497	0.132	0.0033	0	97.6	2.4	Neutral
THYM	Thymoma	119	-0.089	0.335	0.8	90.8	8.4	Neutral
UCEC	Uterine Corpus Endometrial Carcinoma	537	0.269	2.3e-10	1.9	72.1	26.1	Neutral

Summary
Symbol	DNMT3B
Name	DNA methyltransferase 3 beta
Aliases	ICF; ICF1; M.HsaIIIB; DNA MTase HsaIIIB; DNA methyltransferase HsaIIIB; DNA (cytosine-5)-methyltransferase 3 ......
Location	20q11.21
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Methylation level in the promoter region of CR

> Methylation level in the promoter region of CR

[ TOP ]

Correlation between expression and methylation as well as differential methylation analysis.

Cancer	Full Name	R	P	# N	# T	Delta beta (T vs N)	P value (T vs N)	Status
BLCA	Bladder urothelial carcinoma	-0.325	8.53e-12	17	408	-0.055	0.00222	NS/NA
BRCA	Breast invasive carcinoma	-0.239	1.2e-12	83	785	-0.134	6.49e-40	NS/NA
CESC	Cervical and endocervical cancers	-0.304	5.78e-08	3	306	NA	NA	NS/NA
COAD	Colon adenocarcinoma	-0.376	6.91e-12	19	297	-0.006	0.574	NS/NA
ESCA	Esophageal carcinoma	-0.287	5.33e-05	9	185	NA	NA	NS/NA
GBM	Glioblastoma multiforme	-0.289	0.0199	1	64	NA	NA	NS/NA
HNSC	Head and Neck squamous cell carcinoma	-0.196	4.23e-06	20	522	0.016	0.169	NS/NA
KIRC	Kidney renal clear cell carcinoma	-0.283	1.08e-07	24	319	-0.04	4.99e-13	NS/NA
KIRP	Kidney renal papillary cell carcinoma	-0.289	4.16e-07	23	275	-0.054	8.39e-17	NS/NA
LAML	Acute Myeloid Leukemia	-0.54	0	0	170	NA	NA	NS/NA
LGG	Brain Lower Grade Glioma	-0.235	4.56e-08	0	530	NA	NA	NS/NA
LIHC	Liver hepatocellular carcinoma	-0.341	1.41e-12	41	373	-0.063	4.29e-09	NS/NA
LUAD	Lung adenocarcinoma	-0.177	0.000109	21	456	-0.028	8e-06	NS/NA
LUSC	Lung squamous cell carcinoma	-0.303	2.27e-09	8	370	NA	NA	NS/NA
OV	Ovarian serous cystadenocarcinoma	-0.417	0.27	0	9	NA	NA	NS/NA
PAAD	Pancreatic adenocarcinoma	-0.242	0.001	4	179	NA	NA	NS/NA
PCPG	Pheochromocytoma and Paraganglioma	-0.205	0.00495	3	184	NA	NA	NS/NA
PRAD	Prostate adenocarcinoma	-0.283	3.36e-11	35	498	0	0.0699	NS/NA
READ	Rectum adenocarcinoma	-0.229	0.0217	2	99	NA	NA	NS/NA
SARC	Sarcoma	-0.19	0.00199	0	263	NA	NA	NS/NA
SKCM	Skin Cutaneous Melanoma	-0.218	1.9e-06	1	471	NA	NA	NS/NA
STAD	Stomach adenocarcinoma	-0.47	0	0	372	NA	NA	NS/NA
TGCT	Testicular Germ Cell Tumors	-0.527	0	0	156	NA	NA	NS/NA
THCA	Thyroid carcinoma	-0.236	1.79e-08	50	509	0.031	7.73e-05	NS/NA
THYM	Thymoma	-0.747	0	2	120	NA	NA	NS/NA
UCEC	Uterine Corpus Endometrial Carcinoma	-0.404	0	34	431	-0.037	6.83e-23	NS/NA

Summary
Symbol	DNMT3B
Name	DNA methyltransferase 3 beta
Aliases	ICF; ICF1; M.HsaIIIB; DNA MTase HsaIIIB; DNA methyltransferase HsaIIIB; DNA (cytosine-5)-methyltransferase 3 ......
Location	20q11.21
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Primary tumor tissue from TCGA > Normal tumor tissue from HPA

>The Cancer Genome Atlas (TCGA) [ TOP ]
There is no record.

> The Human Protein Atlas (HPA)

[ TOP ]

Tissue	Level	Level Name
Adrenal gland	1	Low
Appendix	2	Medium
Bone marrow	1	Low
Breast	2	Medium
Bronchus	2	Medium
Caudate	1	Low
Cerebellum	1	Low
Cerebral cortex	2	Medium
Cervix, uterine	2	Medium
Colon	2	Medium
Duodenum	2	Medium
Endometrium	2	Medium
Epididymis	2	Medium
Esophagus	0	Not detected
Fallopian tube	2	Medium
Gallbladder	2	Medium
Heart muscle	0	Not detected
Hippocampus	1	Low
Kidney	2	Medium
Liver	0	Not detected
Lung	2	Medium
Lymph node	2	Medium
Nasopharynx	2	Medium
Oral mucosa	2	Medium
Ovary	1	Low
Pancreas	2	Medium
Parathyroid gland	1	Low
Placenta	3	High
Prostate	1	Low
Rectum	2	Medium
Salivary gland	1	Low
Skeletal muscle	0	Not detected
Skin	2	Medium
Small intestine	2	Medium
Smooth muscle	1	Low
Soft tissue	2	Medium
Spleen	1	Low
Stomach	2	Medium
Testis	3	High
Thyroid gland	2	Medium
Tonsil	2	Medium
Urinary bladder	2	Medium
Vagina	2	Medium

Summary
Symbol	DNMT3B
Name	DNA methyltransferase 3 beta
Aliases	ICF; ICF1; M.HsaIIIB; DNA MTase HsaIIIB; DNA methyltransferase HsaIIIB; DNA (cytosine-5)-methyltransferase 3 ......
Location	20q11.21
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Association between expresson and subtype > Overall survival analysis based on expression > Association between expresson and stage > Association between expresson and grade

> Subtype

[ TOP ]

Association between expresson and subtype.

Cancer	Full Name	# Patients	P Value (Kruskal-Wallis)	Association	Source
BLCA	Bladder urothelial carcinoma	128	0.139	NS	24476821
BRCA	Breast invasive carcinoma	521	6.8e-46	Significant	23000897
COAD	Colon adenocarcinoma	149	0.000105	Significant	22810696
GBM	Glioblastoma multiforme	157	3.49e-09	Significant	26824661
HNSC	Head and Neck squamous cell carcinoma	279	3.01e-10	Significant	25631445
KIRP	Kidney renal papillary cell carcinoma	161	0.415	NS	26536169
LGG	Brain Lower Grade Glioma	513	0.0354	Significant	26824661
LUAD	Lung adenocarcinoma	230	1.05e-08	Significant	25079552
LUSC	Lung squamous cell carcinoma	178	0.000187	Significant	22960745
OV	Ovarian serous cystadenocarcinoma	287	0.000304	Significant	21720365
PRAD	Prostate adenocarcinoma	333	0.0733	NS	26544944
READ	Rectum adenocarcinoma	67	0.000585	Significant	22810696
SKCM	Skin Cutaneous Melanoma	315	0.132	NS	26091043
STAD	Stomach adenocarcinoma	277	1.15e-15	Significant	25079317
THCA	Thyroid carcinoma	391	2.73e-16	Significant	25417114
UCEC	Uterine Corpus Endometrial Carcinoma	232	7.8e-10	Significant	23636398

> Overall survival

[ TOP ]

Overall survival analysis based on expression.

Cancer	Full Name	# Patients	Hazard Ratio	P Value (Log Rank Test)	Association
BLCA	Bladder urothelial carcinoma	405	0.658	0.0508	NS
BRCA	Breast invasive carcinoma	1079	1.518	0.0609	NS
CESC	Cervical and endocervical cancers	291	1.555	0.239	NS
COAD	Colon adenocarcinoma	439	1.076	0.787	NS
ESCA	Esophageal carcinoma	184	1.815	0.0632	NS
GBM	Glioblastoma multiforme	158	0.875	0.594	NS
HNSC	Head and Neck squamous cell carcinoma	518	1.209	0.336	NS
KIRC	Kidney renal clear cell carcinoma	531	2.86	5.61e-07	Shorter
KIRP	Kidney renal papillary cell carcinoma	287	4.731	0.00185	Shorter
LAML	Acute Myeloid Leukemia	149	1.927	0.0278	Shorter
LGG	Brain Lower Grade Glioma	511	1.702	0.0281	Shorter
LIHC	Liver hepatocellular carcinoma	365	1.783	0.0238	Shorter
LUAD	Lung adenocarcinoma	502	1.661	0.0142	Shorter
LUSC	Lung squamous cell carcinoma	494	1.178	0.405	NS
OV	Ovarian serous cystadenocarcinoma	303	1.008	0.97	NS
PAAD	Pancreatic adenocarcinoma	177	1.543	0.129	NS
PCPG	Pheochromocytoma and Paraganglioma	179	0.579	0.652	NS
PRAD	Prostate adenocarcinoma	497	1.155	0.86	NS
READ	Rectum adenocarcinoma	159	0.809	0.726	NS
SARC	Sarcoma	259	2.26	0.00242	Shorter
SKCM	Skin Cutaneous Melanoma	459	1.33	0.134	NS
STAD	Stomach adenocarcinoma	388	0.952	0.828	NS
TGCT	Testicular Germ Cell Tumors	134	0.913	0.949	NS
THCA	Thyroid carcinoma	500	1.877	0.326	NS
THYM	Thymoma	119	0.143	0.0541	NS
UCEC	Uterine Corpus Endometrial Carcinoma	543	2.27	0.0218	Shorter

> Stage

[ TOP ]

Association between expresson and stage.

Cancer	Full Name	# Patients	R Value (Spearman)	P Value (Spearman)	Association
BLCA	Bladder urothelial carcinoma	406	0.013	0.791	NS
BRCA	Breast invasive carcinoma	1071	0.081	0.00838	Higher
CESC	Cervical and endocervical cancers	167	-0.011	0.89	NS
COAD	Colon adenocarcinoma	445	0.01	0.833	NS
ESCA	Esophageal carcinoma	162	0.16	0.0415	Higher
HNSC	Head and Neck squamous cell carcinoma	448	-0.082	0.0844	NS
KIRC	Kidney renal clear cell carcinoma	531	0.208	1.37e-06	Higher
KIRP	Kidney renal papillary cell carcinoma	260	0.223	0.000296	Higher
LIHC	Liver hepatocellular carcinoma	347	0.071	0.187	NS
LUAD	Lung adenocarcinoma	507	0.06	0.18	NS
LUSC	Lung squamous cell carcinoma	497	0.14	0.00181	Higher
OV	Ovarian serous cystadenocarcinoma	302	-0.017	0.772	NS
PAAD	Pancreatic adenocarcinoma	176	0.033	0.663	NS
READ	Rectum adenocarcinoma	156	0.029	0.723	NS
SKCM	Skin Cutaneous Melanoma	410	-0.089	0.0731	NS
STAD	Stomach adenocarcinoma	392	-0.028	0.585	NS
TGCT	Testicular Germ Cell Tumors	81	0.394	0.000272	Higher
THCA	Thyroid carcinoma	499	-0.058	0.196	NS
UCEC	Uterine Corpus Endometrial Carcinoma	501	0.139	0.0018	Higher

> Grade

[ TOP ]

Association between expresson and grade.

Cancer	Full Name	# Patients	R Value (Spearman)	P Value (Spearman)	Association
CESC	Cervical and endocervical cancers	272	0.149	0.0137	Higher
HNSC	Head and Neck squamous cell carcinoma	498	-0.173	0.000102	Lower
KIRC	Kidney renal clear cell carcinoma	525	0.179	3.85e-05	Higher
LGG	Brain Lower Grade Glioma	514	0.19	1.47e-05	Higher
LIHC	Liver hepatocellular carcinoma	366	0.228	1.07e-05	Higher
OV	Ovarian serous cystadenocarcinoma	296	0.123	0.0337	Higher
PAAD	Pancreatic adenocarcinoma	176	0.096	0.207	NS
STAD	Stomach adenocarcinoma	406	-0.25	3.19e-07	Lower
UCEC	Uterine Corpus Endometrial Carcinoma	534	0.314	1.19e-13	Higher

Summary
Symbol	DNMT3B
Name	DNA methyltransferase 3 beta
Aliases	ICF; ICF1; M.HsaIIIB; DNA MTase HsaIIIB; DNA methyltransferase HsaIIIB; DNA (cytosine-5)-methyltransferase 3 ......
Location	20q11.21
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Targets inferred by reverse engineering method > Targets identified by ChIP-seq data

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> Targets identified by ChIP-seq data [ TOP ]

Summary
Symbol	DNMT3B
Name	DNA methyltransferase 3 beta
Aliases	ICF; ICF1; M.HsaIIIB; DNA MTase HsaIIIB; DNA methyltransferase HsaIIIB; DNA (cytosine-5)-methyltransferase 3 ......
Location	20q11.21
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Drugs from DrugBank database

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There is no record for DNMT3B.

Summary
Symbol	DNMT3B
Name	DNA methyltransferase 3 beta
Aliases	ICF; ICF1; M.HsaIIIB; DNA MTase HsaIIIB; DNA methyltransferase HsaIIIB; DNA (cytosine-5)-methyltransferase 3 ......
Location	20q11.21
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Protein-Protein Interaction Network > miRNA Regulatory Relationship > Interactions from Text Mining

> Protein-Protein Interaction Network [ TOP ]

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PMID	Cancer	Hierarchy	Gene	Relation to CR	Evidence
21068132	Colorectal Neoplasm	downstream	SFRP2; IGF2	regulation	DNMT3B expression correlated positively with SFRP2 methylation (r = 0.42, p < 0.001, 95% CI 0.25 to 0.56), but correlated negatively with IGF2 DMR0 methylation (r = 0.26, p = 0.01, 95% CI -0.45 to -0.05).
21909138	Hepatocellular Carcinoma	downstream	MTSS1	negative regulation	Taken together, MTSS1, a novel target of DNMT3B, is repressed by DNMT3B via a DNA methylation-independent mechanism.
22919364	Pancreatic Carcinoma	partner	DNMT1	correlation	Expression levels between PPARγ and DNMT1 and between DNMT1 and DNMT3B were highly correlated (P = 0.008 and P = 0.05 resp.).
24625449	Lip and Oral Cavity Carcinoma	upstream	IL-6	Positive regulation	Activated IL-6 signaling might be responsible to the induction of DNMT3b overexpression on oral cancer.
25122426	Lung Carcinoma	upstream	FOXO3a; MDM2	Negative regulation; Positive regulation	We reveal a new mechanism that FOXO3a transcriptionally represses DNMT3B expression and this regulation can be attenuated by MDM2 overexpression in human lung cancer model.
27317771	Bladder Carcinoma	upstream	ANG	negative regulation	Mechanistically, ANG negatively regulated DNA methyltransferase 3b (DNMT3b) enzymatic activity by down-regulating its expression and inhibiting its recruitment to the MMP2 promoter.