CR2Cancer

Summary
Symbol	ERCC6
Name	ERCC excision repair 6, chromatin remodeling factor
Aliases	RAD26; ARMD5; Cockayne syndrome B protein; CKN2; excision repair cross-complementing rodent repair deficienc ......
Location	10q11.23
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Domain, Function and Classification > Gene Ontology > KEGG and Reactome Pathway

> Domain, Function and Classification

[ TOP ]

Domain

PF00271 Helicase conserved C-terminal domain
PF00176 SNF2 family N-terminal domain

Function

Essential factor involved in transcription-coupled nucleotide excision repair which allows RNA polymerase II-blocking lesions to be rapidly removed from the transcribed strand of active genes. Upon DNA-binding, it locally modifies DNA conformation by wrapping the DNA around itself, thereby modifying the interface between stalled RNA polymerase II and DNA. It is required for transcription-coupled repair complex formation. It recruits the CSA complex (DCX(ERCC8) complex), nucleotide excision repair proteins and EP300 to the at sites of RNA polymerase II-blocking lesions. ; FUNCTION: Isoform 2: Like isoform 1, it is involved in repair of DNA damage, acting on its own or synergistically with isoform 1. May bind to PiggyBac transposable elements known as MER85 scattered in the genome and may therefore regulate the expression of nearby genes. Able to stimulate the antiviral response and modulate the expression of genes involved in metabolism regulation.

Classification

Class	Modification	Substrate	Product	PubMed
Chromatin remodelling	#	#	#	15226310

> Gene Ontology [ TOP ]
Biological Process	GO:0000186 activation of MAPKK activity GO:0000187 activation of MAPK activity GO:0000302 response to reactive oxygen species GO:0000303 response to superoxide GO:0000305 response to oxygen radical GO:0001894 tissue homeostasis GO:0001895 retina homeostasis GO:0006283 transcription-coupled nucleotide-excision repair GO:0006284 base-excision repair GO:0006289 nucleotide-excision repair GO:0006290 pyrimidine dimer repair GO:0006354 DNA-templated transcription, elongation GO:0006360 transcription from RNA polymerase I promoter GO:0006362 transcription elongation from RNA polymerase I promoter GO:0006979 response to oxidative stress GO:0007254 JNK cascade GO:0007256 activation of JNKK activity GO:0007257 activation of JUN kinase activity GO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage GO:0009314 response to radiation GO:0009411 response to UV GO:0009416 response to light stimulus GO:0009636 response to toxic substance GO:0010035 response to inorganic substance GO:0010165 response to X-ray GO:0010212 response to ionizing radiation GO:0010224 response to UV-B GO:0010332 response to gamma radiation GO:0018108 peptidyl-tyrosine phosphorylation GO:0018212 peptidyl-tyrosine modification GO:0031098 stress-activated protein kinase signaling cascade GO:0032147 activation of protein kinase activity GO:0032784 regulation of DNA-templated transcription, elongation GO:0032786 positive regulation of DNA-templated transcription, elongation GO:0032872 regulation of stress-activated MAPK cascade GO:0032874 positive regulation of stress-activated MAPK cascade GO:0033674 positive regulation of kinase activity GO:0035264 multicellular organism growth GO:0040029 regulation of gene expression, epigenetic GO:0043405 regulation of MAP kinase activity GO:0043406 positive regulation of MAP kinase activity GO:0043410 positive regulation of MAPK cascade GO:0043506 regulation of JUN kinase activity GO:0043507 positive regulation of JUN kinase activity GO:0045494 photoreceptor cell maintenance GO:0045815 positive regulation of gene expression, epigenetic GO:0045860 positive regulation of protein kinase activity GO:0046328 regulation of JNK cascade GO:0046330 positive regulation of JNK cascade GO:0048871 multicellular organismal homeostasis GO:0050730 regulation of peptidyl-tyrosine phosphorylation GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation GO:0051403 stress-activated MAPK cascade GO:0060249 anatomical structure homeostasis GO:0061097 regulation of protein tyrosine kinase activity GO:0061098 positive regulation of protein tyrosine kinase activity GO:0070302 regulation of stress-activated protein kinase signaling cascade GO:0070304 positive regulation of stress-activated protein kinase signaling cascade GO:0071900 regulation of protein serine/threonine kinase activity GO:0071902 positive regulation of protein serine/threonine kinase activity GO:0097193 intrinsic apoptotic signaling pathway
Molecular Function	GO:0003682 chromatin binding GO:0008022 protein C-terminus binding GO:0008047 enzyme activator activity GO:0008094 DNA-dependent ATPase activity GO:0016887 ATPase activity GO:0019207 kinase regulator activity GO:0019209 kinase activator activity GO:0019887 protein kinase regulator activity GO:0030295 protein kinase activator activity GO:0030296 protein tyrosine kinase activator activity GO:0042623 ATPase activity, coupled GO:0047485 protein N-terminus binding
Cellular Component	GO:0008023 transcription elongation factor complex

> KEGG and Reactome Pathway [ TOP ]
KEGG	hsa03420 Nucleotide excision repair
Reactome	R-HSA-5250924: B-WICH complex positively regulates rRNA expression R-HSA-73894: DNA Repair R-HSA-6782135: Dual incision in TC-NER R-HSA-427389: ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression R-HSA-212165: Epigenetic regulation of gene expression R-HSA-6781823: Formation of TC-NER Pre-Incision Complex R-HSA-6782210: Gap-filling DNA repair synthesis and ligation in TC-NER R-HSA-74160: Gene Expression R-HSA-5696398: Nucleotide Excision Repair R-HSA-5250913: Positive epigenetic regulation of rRNA expression R-HSA-73854: RNA Polymerase I Promoter Clearance R-HSA-73864: RNA Polymerase I Transcription R-HSA-73762: RNA Polymerase I Transcription Initiation R-HSA-504046: RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription R-HSA-6781827: Transcription-Coupled Nucleotide Excision Repair (TC-NER)

> KEGG and Reactome Pathway

[ TOP ]

KEGG

hsa03420 Nucleotide excision repair

Reactome

R-HSA-5250924: B-WICH complex positively regulates rRNA expression
R-HSA-73894: DNA Repair
R-HSA-6782135: Dual incision in TC-NER
R-HSA-427389: ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression
R-HSA-212165: Epigenetic regulation of gene expression
R-HSA-6781823: Formation of TC-NER Pre-Incision Complex
R-HSA-6782210: Gap-filling DNA repair synthesis and ligation in TC-NER
R-HSA-74160: Gene Expression
R-HSA-5696398: Nucleotide Excision Repair
R-HSA-5250913: Positive epigenetic regulation of rRNA expression
R-HSA-73854: RNA Polymerase I Promoter Clearance
R-HSA-73864: RNA Polymerase I Transcription
R-HSA-73762: RNA Polymerase I Transcription Initiation
R-HSA-504046: RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription
R-HSA-6781827: Transcription-Coupled Nucleotide Excision Repair (TC-NER)

Summary
Symbol	ERCC6
Name	ERCC excision repair 6, chromatin remodeling factor
Aliases	RAD26; ARMD5; Cockayne syndrome B protein; CKN2; excision repair cross-complementing rodent repair deficienc ......
Location	10q11.23
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Mutation landscape in primary tumor tissue from TCGA > Mutation landscape in cancer cell line from CCLE > All mutations from COSMIC database V81 > Variations from text mining

> The Cancer Genome Atlas (TCGA) [ TOP ]

> Cancer Cell Line Encyclopedia (CCLE) [ TOP ]

> Catalogue of Somatic Mutations in Cancer (COSMIC)

[ TOP ]

COSMIC ID	CDS change	AA change	Mutation Type	Anatomical Site
COSM427635	c.2300G>A	p.R767H	Substitution - Missense	Breast
COSM5768132	c.2243C>T	p.S748L	Substitution - Missense	Breast
COSM4014452	c.1760C>T	p.T587M	Substitution - Missense	Stomach
COSM4014445	c.2649C>G	p.L883L	Substitution - coding silent	Stomach
COSM146934	c.2751C>T	p.G917G	Substitution - coding silent	Soft_tissue
COSM3935075	c.4041A>T	p.T1347T	Substitution - coding silent	Oesophagus
COSM3751836	c.3637A>G	p.R1213G	Substitution - Missense	Soft_tissue
COSM4600488	c.3481A>C	p.S1161R	Substitution - Missense	Upper_aerodigestive_tract
COSM3438383	c.2123C>T	p.S708F	Substitution - Missense	Liver
COSM684145	c.2091A>T	p.L697F	Substitution - Missense	Lung
COSM13944	c.2925A>G	p.R975R	Substitution - coding silent	Lung
COSM3368054	c.968A>G	p.K323R	Substitution - Missense	Thyroid
COSM918666	c.2045T>G	p.L682R	Substitution - Missense	Endometrium
COSM2145472	c.1596T>C	p.D532D	Substitution - coding silent	Upper_aerodigestive_tract
COSM3415080	c.1954C>T	p.R652*	Substitution - Nonsense	Large_intestine
COSM32242	c.3355G>C	p.E1119Q	Substitution - Missense	Breast
COSM5019449	c.411G>A	p.L137L	Substitution - coding silent	Soft_tissue
COSM146934	c.2751C>T	p.G917G	Substitution - coding silent	Soft_tissue
COSM3665756	c.2327A>C	p.Y776S	Substitution - Missense	Liver
COSM5932605	c.1403G>A	p.W468*	Substitution - Nonsense	Skin
COSM5468419	c.3755T>G	p.L1252W	Substitution - Missense	Large_intestine
COSM3978581	c.2337C>T	p.F779F	Substitution - coding silent	Lung
COSM427634	c.2686C>T	p.P896S	Substitution - Missense	Breast
COSM3438384	c.2001C>T	p.T667T	Substitution - coding silent	Skin
COSM1348067	c.3848A>G	p.E1283G	Substitution - Missense	Large_intestine
COSM5577432	c.1558G>A	p.E520K	Substitution - Missense	Skin
COSM5019449	c.411G>A	p.L137L	Substitution - coding silent	Soft_tissue
COSM4450995	c.1011G>A	p.K337K	Substitution - coding silent	Skin
COSM5050208	c.3700C>A	p.Q1234K	Substitution - Missense	Stomach
COSM3438392	c.789C>T	p.I263I	Substitution - coding silent	Stomach
COSM146933	c.3689G>C	p.R1230P	Substitution - Missense	Soft_tissue
COSM13944	c.2925A>G	p.R975R	Substitution - coding silent	Lung
COSM5019040	c.1196G>A	p.G399D	Substitution - Missense	Soft_tissue
COSM3751836	c.3637A>G	p.R1213G	Substitution - Missense	Soft_tissue
COSM2145471	c.1671T>C	p.R557R	Substitution - coding silent	Upper_aerodigestive_tract
COSM3438391	c.907A>G	p.T303A	Substitution - Missense	Skin
COSM1675224	c.247G>A	p.V83I	Substitution - Missense	Breast
COSM3375479	c.2636A>C	p.K879T	Substitution - Missense	Pancreas
COSM4014438	c.4228G>A	p.G1410R	Substitution - Missense	Stomach
COSM3415078	c.3277G>T	p.D1093Y	Substitution - Missense	Large_intestine
COSM95871	c.378C>T	p.L126L	Substitution - coding silent	Lung
COSM918659	c.2742G>A	p.T914T	Substitution - coding silent	Endometrium
COSM376544	c.295G>T	p.V99F	Substitution - Missense	Lung
COSM3867355	c.628C>T	p.H210Y	Substitution - Missense	Skin
COSM3751836	c.3637A>G	p.R1213G	Substitution - Missense	Soft_tissue
COSM4014441	c.3294T>C	p.S1098S	Substitution - coding silent	Stomach
COSM4989966	c.2298C>T	p.C766C	Substitution - coding silent	Skin
COSM172076	c.4210C>T	p.R1404C	Substitution - Missense	Prostate
COSM190811	c.2338G>A	p.V780I	Substitution - Missense	Large_intestine
COSM2145472	c.1596T>C	p.D532D	Substitution - coding silent	Upper_aerodigestive_tract
COSM4014451	c.1801G>A	p.G601S	Substitution - Missense	Stomach
COSM1348064	c.4328G>A	p.G1443D	Substitution - Missense	Large_intestine
COSM684144	c.1991A>T	p.Q664L	Substitution - Missense	Lung
COSM918676	c.1119G>T	p.E373D	Substitution - Missense	Endometrium
COSM13869	c.3355_3356GA>CT	p.E1119L	Substitution - Missense	Breast
COSM1205623	c.2008C>T	p.R670W	Substitution - Missense	Large_intestine
COSM3438388	c.1828C>T	p.L610L	Substitution - coding silent	Skin
COSM415010	c.1228G>A	p.G410S	Substitution - Missense	Urinary_tract
COSM1702348	c.3493_3494AC>TT	p.T1165L	Substitution - Missense	Skin
COSM4573643	c.1670G>A	p.R557H	Substitution - Missense	Bone
COSM5021135	c.1772C>T	p.P591L	Substitution - Missense	Soft_tissue
COSM5482499	c.4349T>C	p.I1450T	Substitution - Missense	Large_intestine
COSM684133	c.956G>C	p.R319T	Substitution - Missense	Lung
COSM4837296	c.687G>A	p.M229I	Substitution - Missense	Cervix
COSM4014446	c.2421C>T	p.N807N	Substitution - coding silent	Stomach
COSM4014449	c.2125G>A	p.V709I	Substitution - Missense	Stomach
COSM127906	c.4122A>G	p.A1374A	Substitution - coding silent	Upper_aerodigestive_tract
COSM216221	c.4211G>A	p.R1404H	Substitution - Missense	Endometrium
COSM146934	c.2751C>T	p.G917G	Substitution - coding silent	Pancreas
COSM218274	c.2204G>A	p.R735Q	Substitution - Missense	Pancreas
COSM1251473	c.3862C>T	p.R1288*	Substitution - Nonsense	Soft_tissue
COSM918656	c.3260G>A	p.R1087Q	Substitution - Missense	Endometrium
COSM918663	c.2408G>T	p.R803I	Substitution - Missense	Endometrium
COSM3699909	c.2008C>G	p.R670G	Substitution - Missense	Liver
COSM3665756	c.2327A>C	p.Y776S	Substitution - Missense	Liver
COSM1627519	c.1533G>A	p.Q511Q	Substitution - coding silent	Liver
COSM4524601	c.1281C>T	p.F427F	Substitution - coding silent	Skin
COSM4957478	c.4401A>G	p.R1467R	Substitution - coding silent	Liver
COSM146934	c.2751C>T	p.G917G	Substitution - coding silent	Soft_tissue
COSM3675777	c.2751C>G	p.G917G	Substitution - coding silent	Haematopoietic_and_lymphoid_tissue
COSM94246	c.1248A>C	p.K416N	Substitution - Missense	Ovary
COSM1675219	c.4309T>A	p.F1437I	Substitution - Missense	Prostate
COSM4428476	c.1340G>A	p.R447Q	Substitution - Missense	Oesophagus
COSM146934	c.2751C>T	p.G917G	Substitution - coding silent	Soft_tissue
COSM5631123	c.769G>T	p.E257*	Substitution - Nonsense	Oesophagus
COSM146933	c.3689G>C	p.R1230P	Substitution - Missense	Stomach
COSM4524601	c.1281C>T	p.F427F	Substitution - coding silent	Skin
COSM5782059	c.3640G>A	p.D1214N	Substitution - Missense	Breast
COSM5050209	c.1726A>G	p.T576A	Substitution - Missense	Stomach
COSM1321328	c.1742G>A	p.W581*	Substitution - Nonsense	Ovary
COSM1251472	c.3053C>A	p.T1018K	Substitution - Missense	Stomach
COSM1166714	c.3461C>T	p.S1154F	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM146934	c.2751C>T	p.G917G	Substitution - coding silent	Soft_tissue
COSM918651	c.4267G>T	p.E1423*	Substitution - Nonsense	Endometrium
COSM3751837	c.3289A>G	p.M1097V	Substitution - Missense	Large_intestine
COSM918682	c.184G>A	p.A62T	Substitution - Missense	Endometrium
COSM1603494	c.787A>G	p.I263V	Substitution - Missense	Liver
COSM2145537	c.379G>A	p.V127I	Substitution - Missense	Stomach
COSM3438386	c.1862T>C	p.L621S	Substitution - Missense	Skin
COSM918658	c.2859G>C	p.Q953H	Substitution - Missense	Endometrium
COSM3358771	c.1245G>A	p.K415K	Substitution - coding silent	Kidney
COSM5019758	c.2048G>A	p.R683Q	Substitution - Missense	Soft_tissue
COSM4919409	c.1012A>T	p.R338W	Substitution - Missense	Liver
COSM2145472	c.1596T>C	p.D532D	Substitution - coding silent	Upper_aerodigestive_tract
COSM3438392	c.789C>T	p.I263I	Substitution - coding silent	Skin
COSM3358771	c.1245G>A	p.K415K	Substitution - coding silent	Large_intestine
COSM3807284	c.972A>G	p.K324K	Substitution - coding silent	Breast
COSM465701	c.3433G>A	p.E1145K	Substitution - Missense	Kidney
COSM244303	c.341A>G	p.D114G	Substitution - Missense	Prostate
COSM13871	c.3113G>C	p.R1038T	Substitution - Missense	Breast
COSM1348088	c.980G>A	p.R327H	Substitution - Missense	Cervix
COSM2145418	c.4034C>T	p.S1345L	Substitution - Missense	Breast
COSM1627521	c.1027C>T	p.Q343*	Substitution - Nonsense	Liver
COSM1321326	c.423-1G>T	p.?	Unknown	Ovary
COSM4647189	c.4384C>T	p.Q1462*	Substitution - Nonsense	Large_intestine
COSM1348066	c.3868G>T	p.A1290S	Substitution - Missense	Large_intestine
COSM1675222	c.2382G>T	p.Q794H	Substitution - Missense	Prostate
COSM5517407	c.569C>T	p.A190V	Substitution - Missense	Biliary_tract
COSM5962181	c.3450G>T	p.K1150N	Substitution - Missense	Breast
COSM5768259	c.2019G>A	p.L673L	Substitution - coding silent	Breast
COSM5940023	c.1621C>T	p.Q541*	Substitution - Nonsense	Skin
COSM3790817	c.190G>A	p.A64T	Substitution - Missense	Urinary_tract
COSM3790814	c.3121C>T	p.Q1041*	Substitution - Nonsense	Urinary_tract
COSM74540	c.1669C>G	p.R557G	Substitution - Missense	Ovary
COSM146934	c.2751C>T	p.G917G	Substitution - coding silent	Soft_tissue
COSM5789126	c.2268G>C	p.L756F	Substitution - Missense	Breast
COSM5805334	c.653-2A>T	p.?	Unknown	Liver
COSM79178	c.1570C>T	p.Q524*	Substitution - Nonsense	Ovary
COSM146933	c.3689G>C	p.R1230P	Substitution - Missense	Soft_tissue
COSM5014911	c.2135C>A	p.T712N	Substitution - Missense	Kidney
COSM4989965	c.3995G>A	p.G1332D	Substitution - Missense	Skin
COSM280851	c.2606A>G	p.D869G	Substitution - Missense	Large_intestine
COSM427630	c.4238A>G	p.Q1413R	Substitution - Missense	Soft_tissue
COSM918656	c.3260G>A	p.R1087Q	Substitution - Missense	Upper_aerodigestive_tract
COSM3751838	c.528A>G	p.R176R	Substitution - coding silent	Large_intestine
COSM146934	c.2751C>T	p.G917G	Substitution - coding silent	Soft_tissue
COSM427630	c.4238A>G	p.Q1413R	Substitution - Missense	Soft_tissue
COSM32243	c.3356A>T	p.E1119V	Substitution - Missense	Breast
COSM465705	c.429T>G	p.C143W	Substitution - Missense	Kidney
COSM5548466	c.3573A>G	p.A1191A	Substitution - coding silent	Prostate
COSM5019449	c.411G>A	p.L137L	Substitution - coding silent	Haematopoietic_and_lymphoid_tissue
COSM3751837	c.3289A>G	p.M1097V	Substitution - Missense	Soft_tissue
COSM465702	c.2089T>C	p.L697L	Substitution - coding silent	Kidney
COSM4484641	c.2834G>A	p.R945Q	Substitution - Missense	Skin
COSM122894	c.2783G>C	p.R928T	Substitution - Missense	Upper_aerodigestive_tract
COSM4834678	c.3080C>G	p.S1027*	Substitution - Nonsense	Cervix
COSM3438392	c.789C>T	p.I263I	Substitution - coding silent	Skin
COSM4014457	c.1367G>A	p.G456E	Substitution - Missense	Stomach
COSM1348074	c.2776delG	p.A926fs*26	Deletion - Frameshift	Large_intestine
COSM3438383	c.2123C>T	p.S708F	Substitution - Missense	Liver
COSM4144744	c.2546A>G	p.K849R	Substitution - Missense	Thyroid
COSM3867354	c.1789C>T	p.L597L	Substitution - coding silent	Skin
COSM3978580	c.2574A>G	p.V858V	Substitution - coding silent	Lung
COSM918679	c.814G>A	p.E272K	Substitution - Missense	Endometrium
COSM918680	c.431C>T	p.T144M	Substitution - Missense	Upper_aerodigestive_tract
COSM13871	c.3113G>C	p.R1038T	Substitution - Missense	Breast
COSM3438377	c.4372T>C	p.L1458L	Substitution - coding silent	Skin
COSM3415080	c.1954C>T	p.R652*	Substitution - Nonsense	Skin
COSM5826725	c.2925-3delT	p.?	Unknown	Large_intestine
COSM4600928	c.3482G>C	p.S1161T	Substitution - Missense	Upper_aerodigestive_tract
COSM3867352	c.2968C>T	p.P990S	Substitution - Missense	Skin
COSM1474645	c.2144_2145insG	p.Y716fs*44	Insertion - Frameshift	Breast
COSM3438382	c.2219C>T	p.P740L	Substitution - Missense	Skin
COSM13871	c.3113G>C	p.R1038T	Substitution - Missense	Breast
COSM918681	c.405G>A	p.S135S	Substitution - coding silent	Endometrium
COSM1348068	c.3523G>A	p.E1175K	Substitution - Missense	Large_intestine
COSM5915933	c.1805C>T	p.S602F	Substitution - Missense	Skin
COSM427630	c.4238A>G	p.Q1413R	Substitution - Missense	Soft_tissue
COSM3790815	c.1647G>C	p.L549L	Substitution - coding silent	Urinary_tract
COSM1205620	c.1360G>T	p.D454Y	Substitution - Missense	Large_intestine
COSM5019253	c.1337G>A	p.G446D	Substitution - Missense	Soft_tissue
COSM427630	c.4238A>G	p.Q1413R	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM218274	c.2204G>A	p.R735Q	Substitution - Missense	Pancreas
COSM3807279	c.3742G>T	p.D1248Y	Substitution - Missense	Breast
COSM216221	c.4211G>A	p.R1404H	Substitution - Missense	Large_intestine
COSM918679	c.814G>A	p.E272K	Substitution - Missense	Breast
COSM5963467	c.3917G>A	p.G1306E	Substitution - Missense	Breast
COSM3438390	c.1548G>T	p.R516S	Substitution - Missense	Skin
COSM2145539	c.309C>T	p.D103D	Substitution - coding silent	Cervix
COSM4621852	c.3615G>T	p.K1205N	Substitution - Missense	Large_intestine
COSM2145530	c.631G>A	p.A211T	Substitution - Missense	Stomach
COSM5019040	c.1196G>A	p.G399D	Substitution - Missense	Soft_tissue
COSM3438394	c.40G>A	p.E14K	Substitution - Missense	Skin
COSM5019040	c.1196G>A	p.G399D	Substitution - Missense	Soft_tissue
COSM4451555	c.1282C>T	p.P428S	Substitution - Missense	Skin
COSM2145471	c.1671T>C	p.R557R	Substitution - coding silent	Upper_aerodigestive_tract
COSM1726216	c.2833C>T	p.R945W	Substitution - Missense	Liver
COSM3751836	c.3637A>G	p.R1213G	Substitution - Missense	Soft_tissue
COSM1179543	c.1449G>T	p.E483D	Substitution - Missense	Prostate
COSM4014448	c.2203C>T	p.R735*	Substitution - Nonsense	Stomach
COSM146934	c.2751C>T	p.G917G	Substitution - coding silent	Haematopoietic_and_lymphoid_tissue
COSM918652	c.3863G>A	p.R1288Q	Substitution - Missense	Endometrium
COSM3807282	c.1610G>A	p.G537D	Substitution - Missense	Breast
COSM4014458	c.1158C>T	p.D386D	Substitution - coding silent	Stomach
COSM4014447	c.2208T>C	p.D736D	Substitution - coding silent	Stomach
COSM427636	c.2019G>T	p.L673L	Substitution - coding silent	Breast
COSM2145533	c.527G>A	p.R176Q	Substitution - Missense	Large_intestine
COSM1348079	c.1773G>A	p.P591P	Substitution - coding silent	Large_intestine
COSM1348081	c.1483G>A	p.E495K	Substitution - Missense	Large_intestine
COSM3438389	c.1696T>C	p.L566L	Substitution - coding silent	Skin
COSM141289	c.2138T>C	p.M713T	Substitution - Missense	Upper_aerodigestive_tract
COSM3770313	c.4332G>T	p.Q1444H	Substitution - Missense	Soft_tissue
COSM918664	c.2360G>A	p.R787K	Substitution - Missense	Endometrium
COSM1205621	c.1987A>G	p.K663E	Substitution - Missense	Large_intestine
COSM2145543	c.99A>T	p.Q33H	Substitution - Missense	Large_intestine
COSM3438383	c.2123C>T	p.S708F	Substitution - Missense	Skin
COSM918653	c.3662G>A	p.R1221Q	Substitution - Missense	Endometrium
COSM5578493	c.4113T>A	p.S1371R	Substitution - Missense	Skin
COSM918679	c.814G>A	p.E272K	Substitution - Missense	Cervix
COSM3751836	c.3637A>G	p.R1213G	Substitution - Missense	Large_intestine
COSM4755027	c.3805G>A	p.D1269N	Substitution - Missense	Stomach
COSM427630	c.4238A>G	p.Q1413R	Substitution - Missense	Soft_tissue
COSM3438395	c.21C>T	p.P7P	Substitution - coding silent	Skin
COSM381292	c.727G>T	p.G243C	Substitution - Missense	Lung
COSM146934	c.2751C>T	p.G917G	Substitution - coding silent	Soft_tissue
COSM3721667	c.3915G>A	p.L1305L	Substitution - coding silent	Upper_aerodigestive_tract
COSM146934	c.2751C>T	p.G917G	Substitution - coding silent	Soft_tissue
COSM1297293	c.2438C>T	p.S813F	Substitution - Missense	Urinary_tract
COSM4014460	c.197C>T	p.P66L	Substitution - Missense	Stomach
COSM4014439	c.3774A>C	p.K1258N	Substitution - Missense	Stomach
COSM918661	c.2552G>T	p.W851L	Substitution - Missense	Endometrium
COSM4165494	c.896C>T	p.P299L	Substitution - Missense	Kidney
COSM3731072	c.364C>T	p.R122C	Substitution - Missense	Stomach
COSM4528253	c.1521T>A	p.L507L	Substitution - coding silent	Skin
COSM216221	c.4211G>A	p.R1404H	Substitution - Missense	Central_nervous_system
COSM427633	c.2935A>G	p.K979E	Substitution - Missense	Breast
COSM918655	c.3400G>A	p.G1134R	Substitution - Missense	Endometrium
COSM3751837	c.3289A>G	p.M1097V	Substitution - Missense	Soft_tissue
COSM4014448	c.2203C>T	p.R735*	Substitution - Nonsense	Haematopoietic_and_lymphoid_tissue
COSM4014440	c.3629A>C	p.K1210T	Substitution - Missense	Stomach
COSM5726742	c.1169G>A	p.G390E	Substitution - Missense	Skin
COSM5811228	c.2279A>C	p.N760T	Substitution - Missense	Liver
COSM1297294	c.2060C>G	p.S687W	Substitution - Missense	Urinary_tract
COSM5612596	c.422+1G>A	p.?	Unknown	Adrenal_gland
COSM1582063	c.1408A>G	p.K470E	Substitution - Missense	Stomach
COSM3751836	c.3637A>G	p.R1213G	Substitution - Missense	Soft_tissue
COSM94245	c.3082G>A	p.D1028N	Substitution - Missense	Lung
COSM110127	c.756C>T	p.I252I	Substitution - coding silent	Skin
COSM918665	c.2198T>C	p.V733A	Substitution - Missense	Endometrium
COSM5927582	c.2710-7C>T	p.?	Unknown	Skin
COSM3967087	c.4313A>G	p.Q1438R	Substitution - Missense	Central_nervous_system
COSM94244	c.3954G>T	p.R1318S	Substitution - Missense	Lung
COSM1675221	c.2569C>T	p.R857*	Substitution - Nonsense	Large_intestine
COSM5360226	c.1188T>C	p.S396S	Substitution - coding silent	Large_intestine
COSM2145471	c.1671T>C	p.R557R	Substitution - coding silent	Upper_aerodigestive_tract
COSM3751837	c.3289A>G	p.M1097V	Substitution - Missense	Soft_tissue
COSM4974883	c.2135C>G	p.T712S	Substitution - Missense	Oesophagus
COSM1251474	c.2932T>A	p.F978I	Substitution - Missense	Oesophagus
COSM5892072	c.307G>A	p.D103N	Substitution - Missense	Skin
COSM4014450	c.1917C>T	p.D639D	Substitution - coding silent	Stomach
COSM3751837	c.3289A>G	p.M1097V	Substitution - Missense	Soft_tissue
COSM3807286	c.720C>T	p.I240I	Substitution - coding silent	Breast
COSM369778	c.745G>A	p.G249S	Substitution - Missense	Lung
COSM1638575	c.2145_2146insG	p.Y716fs*44	Insertion - Frameshift	Stomach
COSM5703045	c.4417C>A	p.L1473M	Substitution - Missense	Autonomic_ganglia
COSM146934	c.2751C>T	p.G917G	Substitution - coding silent	Soft_tissue
COSM3438385	c.1996C>T	p.R666C	Substitution - Missense	Skin
COSM2145420	c.4010C>A	p.S1337Y	Substitution - Missense	Large_intestine
COSM918660	c.2678C>A	p.S893*	Substitution - Nonsense	Endometrium
COSM1348077	c.2030C>T	p.P677L	Substitution - Missense	Large_intestine
COSM1474644	c.3437G>C	p.S1146T	Substitution - Missense	Breast
COSM918677	c.978G>T	p.E326D	Substitution - Missense	Endometrium
COSM5678761	c.3882G>A	p.L1294L	Substitution - coding silent	Soft_tissue
COSM5804929	c.1208A>T	p.E403V	Substitution - Missense	Liver
COSM2145468	c.1783G>T	p.A595S	Substitution - Missense	Large_intestine
COSM5019040	c.1196G>A	p.G399D	Substitution - Missense	Soft_tissue
COSM1638575	c.2145_2146insG	p.Y716fs*44	Insertion - Frameshift	Stomach
COSM3438385	c.1996C>T	p.R666C	Substitution - Missense	Large_intestine
COSM427630	c.4238A>G	p.Q1413R	Substitution - Missense	Soft_tissue
COSM5019449	c.411G>A	p.L137L	Substitution - coding silent	Breast
COSM2145458	c.2218C>T	p.P740S	Substitution - Missense	Skin
COSM5019040	c.1196G>A	p.G399D	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM427631	c.4139C>T	p.S1380L	Substitution - Missense	Breast
COSM2151469	c.4075A>G	p.K1359E	Substitution - Missense	Central_nervous_system
COSM465704	c.732G>T	p.Q244H	Substitution - Missense	Kidney
COSM5568788	c.2160C>G	p.S720S	Substitution - coding silent	Prostate
COSM3438387	c.1834C>T	p.R612*	Substitution - Nonsense	Skin
COSM3397153	c.2139G>A	p.M713I	Substitution - Missense	Central_nervous_system
COSM1638574	c.2316G>T	p.Q772H	Substitution - Missense	Stomach
COSM95870	c.4467G>A	p.K1489K	Substitution - coding silent	Lung
COSM265378	c.3416C>T	p.S1139F	Substitution - Missense	Large_intestine
COSM918680	c.431C>T	p.T144M	Substitution - Missense	Endometrium
COSM1638573	c.4431T>C	p.H1477H	Substitution - coding silent	Stomach
COSM4755029	c.3164A>C	p.K1055T	Substitution - Missense	Stomach
COSM3375479	c.2636A>C	p.K879T	Substitution - Missense	Pancreas
COSM146933	c.3689G>C	p.R1230P	Substitution - Missense	Soft_tissue
COSM2145467	c.1820delA	p.K607fs*4	Deletion - Frameshift	Large_intestine
COSM3751837	c.3289A>G	p.M1097V	Substitution - Missense	Soft_tissue
COSM3790816	c.235C>T	p.Q79*	Substitution - Nonsense	Urinary_tract
COSM3751837	c.3289A>G	p.M1097V	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM4681598	c.1861T>C	p.L621L	Substitution - coding silent	Large_intestine
COSM5605705	c.420C>T	p.L140L	Substitution - coding silent	Skin
COSM5019783	c.3650T>G	p.F1217C	Substitution - Missense	Soft_tissue
COSM4462503	c.124G>T	p.E42*	Substitution - Nonsense	Skin
COSM275005	c.3158G>A	p.R1053H	Substitution - Missense	Large_intestine
COSM4890930	c.3580G>C	p.E1194Q	Substitution - Missense	Upper_aerodigestive_tract
COSM5341257	c.4330C>T	p.Q1444*	Substitution - Nonsense	Large_intestine
COSM2145472	c.1596T>C	p.D532D	Substitution - coding silent	Pancreas
COSM4681604	c.401G>A	p.R134Q	Substitution - Missense	Large_intestine
COSM5019449	c.411G>A	p.L137L	Substitution - coding silent	Soft_tissue
COSM3397154	c.2099T>C	p.L700S	Substitution - Missense	Central_nervous_system
COSM146934	c.2751C>T	p.G917G	Substitution - coding silent	Soft_tissue
COSM4573644	c.1347G>A	p.V449V	Substitution - coding silent	Bone
COSM427630	c.4238A>G	p.Q1413R	Substitution - Missense	Thyroid
COSM218274	c.2204G>A	p.R735Q	Substitution - Missense	Pancreas
COSM1675220	c.3844G>A	p.V1282M	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM2145532	c.560delA	p.K187fs*18	Deletion - Frameshift	Large_intestine
COSM4989969	c.2013C>T	p.I671I	Substitution - coding silent	Skin
COSM4890855	c.4450G>C	p.G1484R	Substitution - Missense	Upper_aerodigestive_tract
COSM146934	c.2751C>T	p.G917G	Substitution - coding silent	Large_intestine
COSM3438381	c.2505G>A	p.W835*	Substitution - Nonsense	Skin
COSM1675221	c.2569C>T	p.R857*	Substitution - Nonsense	Large_intestine
COSM5738894	c.2626A>G	p.R876G	Substitution - Missense	Small_intestine
COSM4014444	c.2838G>T	p.E946D	Substitution - Missense	Stomach
COSM1187942	c.1970C>T	p.A657V	Substitution - Missense	Lung
COSM13869	c.3355_3356GA>CT	p.E1119L	Substitution - Missense	Breast
COSM3807277	c.4193A>C	p.H1398P	Substitution - Missense	Breast
COSM2145457	c.2230C>T	p.R744W	Substitution - Missense	Skin
COSM4681603	c.856A>T	p.K286*	Substitution - Nonsense	Large_intestine
COSM396358	c.871A>T	p.N291Y	Substitution - Missense	Lung
COSM1348072	c.3042G>T	p.Q1014H	Substitution - Missense	Large_intestine
COSM5019040	c.1196G>A	p.G399D	Substitution - Missense	Soft_tissue
COSM918657	c.2944T>G	p.L982V	Substitution - Missense	Endometrium
COSM1675221	c.2569C>T	p.R857*	Substitution - Nonsense	Large_intestine
COSM218274	c.2204G>A	p.R735Q	Substitution - Missense	Skin
COSM4989967	c.2073C>T	p.F691F	Substitution - coding silent	Skin
COSM280852	c.1345G>A	p.V449M	Substitution - Missense	Large_intestine
COSM918654	c.3437G>T	p.S1146I	Substitution - Missense	Endometrium
COSM1348065	c.4203G>A	p.L1401L	Substitution - coding silent	Large_intestine
COSM1348076	c.2124C>T	p.S708S	Substitution - coding silent	Large_intestine
COSM4014443	c.2856C>T	p.G952G	Substitution - coding silent	Stomach
COSM1205622	c.437C>T	p.S146F	Substitution - Missense	Large_intestine
COSM918678	c.880G>A	p.A294T	Substitution - Missense	Endometrium
COSM3807281	c.2467C>A	p.P823T	Substitution - Missense	Breast
COSM1297292	c.3877G>A	p.A1293T	Substitution - Missense	Urinary_tract
COSM5019449	c.411G>A	p.L137L	Substitution - coding silent	Haematopoietic_and_lymphoid_tissue
COSM3985631	c.2744G>A	p.R915Q	Substitution - Missense	Kidney
COSM4014442	c.3157C>T	p.R1053C	Substitution - Missense	Stomach
COSM2145451	c.2538T>C	p.S846S	Substitution - coding silent	Central_nervous_system
COSM5019040	c.1196G>A	p.G399D	Substitution - Missense	Soft_tissue
COSM5665615	c.4150delC	p.L1384fs*10	Deletion - Frameshift	Soft_tissue
COSM3807280	c.2645A>C	p.Y882S	Substitution - Missense	Breast
COSM4565139	c.1771_1772CC>TT	p.P591L	Substitution - Missense	Skin
COSM427630	c.4238A>G	p.Q1413R	Substitution - Missense	Soft_tissue
COSM3751836	c.3637A>G	p.R1213G	Substitution - Missense	Soft_tissue
COSM4014459	c.630C>T	p.H210H	Substitution - coding silent	Stomach
COSM3807278	c.4062G>T	p.Q1354H	Substitution - Missense	Breast
COSM3438379	c.3168C>T	p.F1056F	Substitution - coding silent	Skin
COSM4916431	c.3949C>T	p.H1317Y	Substitution - Missense	Liver
COSM5041340	c.1568G>C	p.C523S	Substitution - Missense	Liver
COSM4455828	c.916G>A	p.A306T	Substitution - Missense	Skin
COSM427630	c.4238A>G	p.Q1413R	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM3807285	c.919C>G	p.P307A	Substitution - Missense	Breast
COSM146933	c.3689G>C	p.R1230P	Substitution - Missense	Large_intestine
COSM4989968	c.2046C>T	p.L682L	Substitution - coding silent	Skin
COSM4681597	c.2461G>T	p.G821C	Substitution - Missense	Large_intestine
COSM146933	c.3689G>C	p.R1230P	Substitution - Missense	Soft_tissue
COSM32310	c.1771C>G	p.P591A	Substitution - Missense	Large_intestine
COSM1128042	c.4399C>T	p.R1467*	Substitution - Nonsense	Prostate
COSM918662	c.2547A>C	p.K849N	Substitution - Missense	Endometrium
COSM427637	c.625G>C	p.D209H	Substitution - Missense	Breast
COSM3867353	c.2345C>T	p.S782F	Substitution - Missense	Skin
COSM4014442	c.3157C>T	p.R1053C	Substitution - Missense	Large_intestine
COSM330755	c.2388C>T	p.F796F	Substitution - coding silent	Lung
COSM3438378	c.4098C>T	p.V1366V	Substitution - coding silent	Skin
COSM33281	c.1955G>T	p.R652L	Substitution - Missense	Large_intestine
COSM3415079	c.3003C>T	p.L1001L	Substitution - coding silent	Large_intestine
COSM3438393	c.170C>T	p.S57F	Substitution - Missense	Skin
COSM3751837	c.3289A>G	p.M1097V	Substitution - Missense	Soft_tissue
COSM5019449	c.411G>A	p.L137L	Substitution - coding silent	Soft_tissue
COSM1348078	c.1955G>A	p.R652Q	Substitution - Missense	Large_intestine
COSM2145532	c.560delA	p.K187fs*18	Deletion - Frameshift	Pancreas
COSM4940739	c.2084G>T	p.G695V	Substitution - Missense	Liver
COSM1187941	c.3842T>C	p.L1281P	Substitution - Missense	Lung
COSM4144743	c.2551T>G	p.W851G	Substitution - Missense	Thyroid
COSM4957478	c.4401A>G	p.R1467R	Substitution - coding silent	Liver
COSM427632	c.3510G>A	p.E1170E	Substitution - coding silent	Breast
COSM2145471	c.1671T>C	p.R557R	Substitution - coding silent	Upper_aerodigestive_tract
COSM3807283	c.1207G>A	p.E403K	Substitution - Missense	Breast
COSM4418778	c.3637A>C	p.R1213R	Substitution - coding silent	Haematopoietic_and_lymphoid_tissue
COSM190811	c.2338G>A	p.V780I	Substitution - Missense	Oesophagus
COSM2151469	c.4075A>G	p.K1359E	Substitution - Missense	Central_nervous_system
COSM146934	c.2751C>T	p.G917G	Substitution - coding silent	Stomach
COSM5000494	c.3494C>T	p.T1165I	Substitution - Missense	Pancreas
COSM684145	c.2091A>T	p.L697F	Substitution - Missense	Lung
COSM320163	c.4121C>T	p.A1374V	Substitution - Missense	Lung
COSM684147	c.3405A>G	p.T1135T	Substitution - coding silent	Lung
COSM3438380	c.2622C>T	p.F874F	Substitution - coding silent	Skin
COSM1582062	c.3023C>T	p.T1008I	Substitution - Missense	Stomach
COSM373758	c.1226A>T	p.K409M	Substitution - Missense	Lung
COSM4681596	c.2890A>G	p.T964A	Substitution - Missense	Large_intestine
COSM3751836	c.3637A>G	p.R1213G	Substitution - Missense	Soft_tissue
COSM146934	c.2751C>T	p.G917G	Substitution - coding silent	Soft_tissue
COSM5703626	c.1676C>A	p.S559*	Substitution - Nonsense	Haematopoietic_and_lymphoid_tissue
COSM1251473	c.3862C>T	p.R1288*	Substitution - Nonsense	Oesophagus
COSM5019040	c.1196G>A	p.G399D	Substitution - Missense	Soft_tissue
COSM1348088	c.980G>A	p.R327H	Substitution - Missense	Large_intestine
COSM5019040	c.1196G>A	p.G399D	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM3751837	c.3289A>G	p.M1097V	Substitution - Missense	Soft_tissue
COSM1675218	c.4333G>T	p.A1445S	Substitution - Missense	Kidney
COSM427630	c.4238A>G	p.Q1413R	Substitution - Missense	Soft_tissue
COSM265800	c.2354T>A	p.V785D	Substitution - Missense	Large_intestine

> Text Mining based Variations

[ TOP ]

PMID	Variation	Cancer	Evidence
21643987	mutation	Anaplastic Glioma	In this dataset, eight gene variants mapping to five different DNA repair genes (ATM, NEIL1, NEIL2, ERCC6 and RPA4) which were associated with survival.
28202063	mutation	Endometrioid Stromal Sarcoma	These 19 mutations were found in 13 different genes such as: ABCC12, APC, ATM, BRCA1, BRCA2, CDH1, ERCC6, MSH2, POLH, PRF1, SLX4, STK11 and TP53.

Summary
Symbol	ERCC6
Name	ERCC excision repair 6, chromatin remodeling factor
Aliases	RAD26; ARMD5; Cockayne syndrome B protein; CKN2; excision repair cross-complementing rodent repair deficienc ......
Location	10q11.23
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Post-translational modification (PTM)

> Post-translational modification (PTM)

[ TOP ]

Filter By:

Uniprot ID	Position	Amino Acid	Description	Upstream Enzyme	Affected By Mutation	Amino Acid Sequence Variant
Q03468	297	K	N6-methylated lysine	EHMT2	No	None detected
Q03468	448	K	N6-methylated lysine	EHMT2	No	None detected
Q03468	486	S	Phosphoserine	-	No	None detected
Q03468	489	S	Phosphoserine	-	No	None detected
Q03468	1054	K	N6-methylated lysine	EHMT2	No	None detected
Q03468	1142	S	Phosphoserine	-	No	None detected
Q03468	1348	S	Phosphoserine	-	No	None detected

Summary
Symbol	ERCC6
Name	ERCC excision repair 6, chromatin remodeling factor
Aliases	RAD26; ARMD5; Cockayne syndrome B protein; CKN2; excision repair cross-complementing rodent repair deficienc ......
Location	10q11.23
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Expression analysis in primary tumor tissue from TCGA > Expression level in cancer cell line from CCLE > Expression level in human normal tissue from HPA > Text mining based expression change

> The Cancer Genome Atlas (TCGA)

[ TOP ]

Differential expression analysis for cancers with more than 10 normal samples

Cancer	Full Name	# N	# T	Median (N)	Median (T)	LogFC	Adj. P	Status
BLCA	Bladder urothelial carcinoma	19	408	3.605	3.71	0.147	0.498	NS
BRCA	Breast invasive carcinoma	112	1100	4.203	4.086	-0.042	0.543	NS
CESC	Cervical and endocervical cancers	3	306	3.55	3.765	NA	NA	NA
COAD	Colon adenocarcinoma	41	459	3.474	3.403	-0.137	0.125	NS
ESCA	Esophageal carcinoma	11	185	4.131	4.18	0.075	0.799	NS
GBM	Glioblastoma multiforme	5	166	3.62	2.407	NA	NA	NA
HNSC	Head and Neck squamous cell carcinoma	44	522	3.965	3.943	0.053	0.677	NS
KIRC	Kidney renal clear cell carcinoma	72	534	3.9	3.453	-0.517	1.99e-13	NS
KIRP	Kidney renal papillary cell carcinoma	32	291	3.555	3.121	-0.364	0.00447	NS
LAML	Acute Myeloid Leukemia	0	173	NA	4.608	NA	NA	NA
LGG	Brain Lower Grade Glioma	0	530	NA	3.503	NA	NA	NA
LIHC	Liver hepatocellular carcinoma	50	373	2.392	2.027	-0.294	0.00377	NS
LUAD	Lung adenocarcinoma	59	517	3.616	3.703	0.223	0.0104	NS
LUSC	Lung squamous cell carcinoma	51	501	3.521	3.79	0.315	0.000609	NS
OV	Ovarian serous cystadenocarcinoma	0	307	NA	3.784	NA	NA	NA
PAAD	Pancreatic adenocarcinoma	4	179	3.211	3.309	NA	NA	NA
PCPG	Pheochromocytoma and Paraganglioma	3	184	2.489	3.014	NA	NA	NA
PRAD	Prostate adenocarcinoma	52	498	3.895	3.769	-0.044	0.656	NS
READ	Rectum adenocarcinoma	10	167	3.322	3.407	-0.037	0.872	NS
SARC	Sarcoma	2	263	2.489	2.86	NA	NA	NA
SKCM	Skin Cutaneous Melanoma	1	472	2.758	2.84	NA	NA	NA
STAD	Stomach adenocarcinoma	35	415	3.385	3.682	0.189	0.118	NS
TGCT	Testicular Germ Cell Tumors	0	156	NA	3.701	NA	NA	NA
THCA	Thyroid carcinoma	59	509	4.299	4.177	-0.075	0.358	NS
THYM	Thymoma	2	120	3.627	3.212	NA	NA	NA
UCEC	Uterine Corpus Endometrial Carcinoma	35	546	3.538	3.356	-0.119	0.255	NS

> Cancer Cell Line Encyclopedia (CCLE)

[ TOP ]

Tissue	Cell Line	Expression Level (Microarray)
Autonomic ganglia	CHP126	5.8
Autonomic ganglia	CHP212	5.3
Autonomic ganglia	IMR32	5.3
Autonomic ganglia	KELLY	5.6
Autonomic ganglia	KPNRTBM1	5.3
Autonomic ganglia	KPNSI9S	5
Autonomic ganglia	KPNYN	4.8
Autonomic ganglia	MHHNB11	5.6
Autonomic ganglia	NB1	5.1
Autonomic ganglia	NH6	5.4
Autonomic ganglia	SHSY5Y	5.5
Autonomic ganglia	SIMA	6.1
Autonomic ganglia	SKNAS	5.5
Autonomic ganglia	SKNBE2	5.4
Autonomic ganglia	SKNDZ	5.1
Autonomic ganglia	SKNFI	5.9
Autonomic ganglia	SKNSH	5
Biliary tract	HUCCT1	5.4
Biliary tract	HUH28	6
Biliary tract	SNU1079	5.4
Biliary tract	SNU1196	5.8
Biliary tract	SNU245	5.3
Biliary tract	SNU308	4.8
Biliary tract	SNU478	5.2
Bone	143B	6
Bone	A673	4.8
Bone	CADOES1	5.3
Bone	CAL78	5.5
Bone	G292CLONEA141B1	5.5
Bone	HOS	5.1
Bone	HS706T	5.4
Bone	HS737T	7.7
Bone	HS819T	7
Bone	HS821T	6.5
Bone	HS822T	6.6
Bone	HS863T	7.1
Bone	HS870T	7
Bone	HS888T	5.4
Bone	MG63	5.7
Bone	MHHES1	5.4
Bone	OUMS27	6.3
Bone	RDES	5.2
Bone	SJSA1	5
Bone	SKES1	4.7
Bone	SKNMC	5.6
Bone	SW1353	6.3
Bone	T173	8.1
Bone	TC71	5.5
Bone	U2OS	5.7
Breast	AU565	5.4
Breast	BT20	6.2
Breast	BT474	5.6
Breast	BT483	5.9
Breast	BT549	5.9
Breast	CAL120	6.5
Breast	CAL148	5.6
Breast	CAL51	5.5
Breast	CAL851	5.9
Breast	CAMA1	5.4
Breast	DU4475	5.5
Breast	EFM192A	5.6
Breast	EFM19	5.8
Breast	EVSAT	5.5
Breast	HCC1143	6
Breast	HCC1187	6.1
Breast	HCC1395	5.9
Breast	HCC1419	5.7
Breast	HCC1428	6.5
Breast	HCC1500	5.7
Breast	HCC1569	5.4
Breast	HCC1599	6
Breast	HCC1806	5.6
Breast	HCC1937	5.2
Breast	HCC1954	5.6
Breast	HCC202	5.4
Breast	HCC2157	5.8
Breast	HCC2218	5.6
Breast	HCC38	6.3
Breast	HCC70	5.7
Breast	HDQP1	5.6
Breast	HMC18	5.1
Breast	HS274T	8.3
Breast	HS281T	6.8
Breast	HS343T	6.5
Breast	HS578T	5.8
Breast	HS606T	6.1
Breast	HS739T	6.7
Breast	HS742T	6.3
Breast	JIMT1	6.6
Breast	KPL1	5.4
Breast	MCF7	4.9
Breast	MDAMB134VI	5.4
Breast	MDAMB157	5
Breast	MDAMB175VII	5.3
Breast	MDAMB231	5.9
Breast	MDAMB361	6
Breast	MDAMB415	5.2
Breast	MDAMB436	5.1
Breast	MDAMB453	6.1
Breast	MDAMB468	5.5
Breast	SKBR3	5.7
Breast	T47D	5.8
Breast	UACC812	6
Breast	UACC893	5.9
Breast	YMB1	5.5
Breast	ZR751	5.3
Breast	ZR7530	5.8
Central nervous system	1321N1	5.2
Central nervous system	42MGBA	5.6
Central nervous system	8MGBA	5.2
Central nervous system	A172	4.8
Central nervous system	AM38	6
Central nervous system	BECKER	5.5
Central nervous system	CAS1	5.4
Central nervous system	CCFSTTG1	5.1
Central nervous system	D283MED	5.1
Central nervous system	D341MED	5.8
Central nervous system	DAOY	5.2
Central nervous system	DBTRG05MG	5.4
Central nervous system	DKMG	4.9
Central nervous system	GAMG	5.2
Central nervous system	GB1	6.1
Central nervous system	GI1	4.9
Central nervous system	GMS10	5.7
Central nervous system	GOS3	5
Central nervous system	H4	5.9
Central nervous system	HS683	4.8
Central nervous system	KALS1	5.1
Central nervous system	KG1C	5.2
Central nervous system	KNS42	5.6
Central nervous system	KNS60	5.6
Central nervous system	KNS81	4.9
Central nervous system	KS1	8
Central nervous system	LN18	5.4
Central nervous system	LN229	5.4
Central nervous system	M059K	6
Central nervous system	MOGGCCM	5.2
Central nervous system	MOGGUVW	6
Central nervous system	NMCG1	5.5
Central nervous system	ONS76	5.3
Central nervous system	SF126	6.1
Central nervous system	SF295	5.3
Central nervous system	SNB19	5.3
Central nervous system	SNU1105	5.1
Central nervous system	SNU201	4.9
Central nervous system	SNU466	6.2
Central nervous system	SNU489	5.8
Central nervous system	SNU626	5
Central nervous system	SNU738	5.8
Central nervous system	SW1088	5.1
Central nervous system	SW1783	5.8
Central nervous system	T98G	5
Central nervous system	TM31	6.5
Central nervous system	U118MG	5.3
Central nervous system	U138MG	5
Central nervous system	U251MG	5.5
Central nervous system	U87MG	5.6
Central nervous system	YH13	5.4
Central nervous system	YKG1	5
Endometrium	AN3CA	5.2
Endometrium	COLO684	5
Endometrium	EFE184	5.4
Endometrium	EN	5.1
Endometrium	ESS1	6.3
Endometrium	HEC108	5.7
Endometrium	HEC151	4.9
Endometrium	HEC1A	5.4
Endometrium	HEC1B	5.1
Endometrium	HEC251	5.8
Endometrium	HEC265	5.7
Endometrium	HEC50B	4.7
Endometrium	HEC59	5.4
Endometrium	HEC6	5.2
Endometrium	ISHIKAWAHERAKLIO02ER	5.9
Endometrium	JHUEM1	5.8
Endometrium	JHUEM2	5.5
Endometrium	JHUEM3	4.9
Endometrium	KLE	5.5
Endometrium	MFE280	4.8
Endometrium	MFE296	5.6
Endometrium	MFE319	5.6
Endometrium	RL952	6.1
Endometrium	SNGM	5.6
Endometrium	SNU1077	5.4
Endometrium	SNU685	4.8
Endometrium	TEN	5.2
Haematopoietic and lymphoid	697	4.6
Haematopoietic and lymphoid	A3KAW	5.6
Haematopoietic and lymphoid	A4FUK	5.5
Haematopoietic and lymphoid	ALLSIL	5.5
Haematopoietic and lymphoid	AML193	5.7
Haematopoietic and lymphoid	AMO1	5.2
Haematopoietic and lymphoid	BCP1	5.8
Haematopoietic and lymphoid	BDCM	5.7
Haematopoietic and lymphoid	BL41	5
Haematopoietic and lymphoid	BL70	5.5
Haematopoietic and lymphoid	BV173	5.4
Haematopoietic and lymphoid	CA46	5.9
Haematopoietic and lymphoid	CI1	5.9
Haematopoietic and lymphoid	CMK115	5.6
Haematopoietic and lymphoid	CMK86	5.2
Haematopoietic and lymphoid	CMK	5.6
Haematopoietic and lymphoid	CMLT1	5.9
Haematopoietic and lymphoid	COLO775	4.7
Haematopoietic and lymphoid	DAUDI	5.6
Haematopoietic and lymphoid	DB	6.4
Haematopoietic and lymphoid	DEL	5.4
Haematopoietic and lymphoid	DND41	5.4
Haematopoietic and lymphoid	DOHH2	5.4
Haematopoietic and lymphoid	EB1	5.2
Haematopoietic and lymphoid	EB2	5.6
Haematopoietic and lymphoid	EHEB	6.1
Haematopoietic and lymphoid	EJM	5.5
Haematopoietic and lymphoid	EM2	6.1
Haematopoietic and lymphoid	EOL1	5.7
Haematopoietic and lymphoid	F36P	5.3
Haematopoietic and lymphoid	GA10	5.3
Haematopoietic and lymphoid	GDM1	5.4
Haematopoietic and lymphoid	GRANTA519	5.5
Haematopoietic and lymphoid	HDLM2	5.7
Haematopoietic and lymphoid	HDMYZ	6.1
Haematopoietic and lymphoid	HEL9217	5.2
Haematopoietic and lymphoid	HEL	5
Haematopoietic and lymphoid	HH	5.4
Haematopoietic and lymphoid	HL60	5.6
Haematopoietic and lymphoid	HPBALL	5.2
Haematopoietic and lymphoid	HS604T	6.4
Haematopoietic and lymphoid	HS611T	5.9
Haematopoietic and lymphoid	HS616T	8.1
Haematopoietic and lymphoid	HS751T	7.2
Haematopoietic and lymphoid	HT	6.3
Haematopoietic and lymphoid	HTK	4.8
Haematopoietic and lymphoid	HUNS1	5.7
Haematopoietic and lymphoid	HUT102	6.4
Haematopoietic and lymphoid	HUT78	5.8
Haematopoietic and lymphoid	JEKO1	5.1
Haematopoietic and lymphoid	JK1	5.7
Haematopoietic and lymphoid	JM1	5.3
Haematopoietic and lymphoid	JURKAT	5.3
Haematopoietic and lymphoid	JURLMK1	5.3
Haematopoietic and lymphoid	JVM2	6.2
Haematopoietic and lymphoid	JVM3	5.7
Haematopoietic and lymphoid	K562	5.9
Haematopoietic and lymphoid	KARPAS299	4.9
Haematopoietic and lymphoid	KARPAS422	6.2
Haematopoietic and lymphoid	KARPAS620	5.5
Haematopoietic and lymphoid	KASUMI1	5.9
Haematopoietic and lymphoid	KASUMI2	5.2
Haematopoietic and lymphoid	KASUMI6	6.2
Haematopoietic and lymphoid	KCL22	5.3
Haematopoietic and lymphoid	KE37	5.7
Haematopoietic and lymphoid	KE97	5.2
Haematopoietic and lymphoid	KG1	5.7
Haematopoietic and lymphoid	KHM1B	5.6
Haematopoietic and lymphoid	KIJK	5.2
Haematopoietic and lymphoid	KMH2	4.9
Haematopoietic and lymphoid	KMM1	5.3
Haematopoietic and lymphoid	KMS11	5.3
Haematopoietic and lymphoid	KMS12BM	4.9
Haematopoietic and lymphoid	KMS18	5.5
Haematopoietic and lymphoid	KMS20	5.9
Haematopoietic and lymphoid	KMS21BM	5.2
Haematopoietic and lymphoid	KMS26	5.7
Haematopoietic and lymphoid	KMS27	5.3
Haematopoietic and lymphoid	KMS28BM	5.2
Haematopoietic and lymphoid	KMS34	5.4
Haematopoietic and lymphoid	KO52	5.4
Haematopoietic and lymphoid	KOPN8	5.4
Haematopoietic and lymphoid	KU812	5.5
Haematopoietic and lymphoid	KYO1	5.9
Haematopoietic and lymphoid	L1236	5.8
Haematopoietic and lymphoid	L363	5.8
Haematopoietic and lymphoid	L428	5.2
Haematopoietic and lymphoid	L540	5.6
Haematopoietic and lymphoid	LAMA84	6.4
Haematopoietic and lymphoid	LOUCY	5.5
Haematopoietic and lymphoid	LP1	5.6
Haematopoietic and lymphoid	M07E	5.8
Haematopoietic and lymphoid	MC116	5.8
Haematopoietic and lymphoid	ME1	5.6
Haematopoietic and lymphoid	MEC1	6
Haematopoietic and lymphoid	MEC2	5.1
Haematopoietic and lymphoid	MEG01	5.3
Haematopoietic and lymphoid	MHHCALL2	5.5
Haematopoietic and lymphoid	MHHCALL3	5.2
Haematopoietic and lymphoid	MHHCALL4	5.5
Haematopoietic and lymphoid	MINO	5.5
Haematopoietic and lymphoid	MJ	5.2
Haematopoietic and lymphoid	MM1S	5.3
Haematopoietic and lymphoid	MOLM13	5.3
Haematopoietic and lymphoid	MOLM16	5.6
Haematopoietic and lymphoid	MOLM6	6.3
Haematopoietic and lymphoid	MOLP2	5.8
Haematopoietic and lymphoid	MOLP8	4.8
Haematopoietic and lymphoid	MOLT13	5.8
Haematopoietic and lymphoid	MOLT16	5.7
Haematopoietic and lymphoid	MOLT4	5.2
Haematopoietic and lymphoid	MONOMAC1	5.7
Haematopoietic and lymphoid	MONOMAC6	5.8
Haematopoietic and lymphoid	MOTN1	6.5
Haematopoietic and lymphoid	MUTZ5	6
Haematopoietic and lymphoid	MV411	5.7
Haematopoietic and lymphoid	NALM19	5.3
Haematopoietic and lymphoid	NALM1	5.5
Haematopoietic and lymphoid	NALM6	5.3
Haematopoietic and lymphoid	NAMALWA	5.4
Haematopoietic and lymphoid	NB4	5.2
Haematopoietic and lymphoid	NCIH929	5.3
Haematopoietic and lymphoid	NCO2	5.9
Haematopoietic and lymphoid	NOMO1	5.5
Haematopoietic and lymphoid	NUDHL1	6
Haematopoietic and lymphoid	NUDUL1	5.3
Haematopoietic and lymphoid	OCIAML2	6.1
Haematopoietic and lymphoid	OCIAML3	6.3
Haematopoietic and lymphoid	OCIAML5	6.2
Haematopoietic and lymphoid	OCILY10	5.9
Haematopoietic and lymphoid	OCILY19	5.8
Haematopoietic and lymphoid	OCILY3	5.7
Haematopoietic and lymphoid	OCIM1	6.4
Haematopoietic and lymphoid	OPM2	5.3
Haematopoietic and lymphoid	P12ICHIKAWA	5.5
Haematopoietic and lymphoid	P31FUJ	5.5
Haematopoietic and lymphoid	P3HR1	5.3
Haematopoietic and lymphoid	PCM6	5.4
Haematopoietic and lymphoid	PEER	5.3
Haematopoietic and lymphoid	PF382	5.9
Haematopoietic and lymphoid	PFEIFFER	6
Haematopoietic and lymphoid	PL21	5.2
Haematopoietic and lymphoid	RAJI	5.5
Haematopoietic and lymphoid	RCHACV	5.2
Haematopoietic and lymphoid	REC1	5.6
Haematopoietic and lymphoid	REH	5.2
Haematopoietic and lymphoid	RI1	5.4
Haematopoietic and lymphoid	RL	5.9
Haematopoietic and lymphoid	RPMI8226	5
Haematopoietic and lymphoid	RPMI8402	5.6
Haematopoietic and lymphoid	RS411	5.4
Haematopoietic and lymphoid	SEM	5.2
Haematopoietic and lymphoid	SET2	5.1
Haematopoietic and lymphoid	SIGM5	4.9
Haematopoietic and lymphoid	SKM1	5.5
Haematopoietic and lymphoid	SKMM2	5.2
Haematopoietic and lymphoid	SR786	5.8
Haematopoietic and lymphoid	ST486	5.5
Haematopoietic and lymphoid	SUDHL10	6.2
Haematopoietic and lymphoid	SUDHL1	5.4
Haematopoietic and lymphoid	SUDHL4	6
Haematopoietic and lymphoid	SUDHL5	5.4
Haematopoietic and lymphoid	SUDHL6	5.7
Haematopoietic and lymphoid	SUDHL8	5.3
Haematopoietic and lymphoid	SUPB15	5.3
Haematopoietic and lymphoid	SUPHD1	6.5
Haematopoietic and lymphoid	SUPM2	5.4
Haematopoietic and lymphoid	SUPT11	5.5
Haematopoietic and lymphoid	SUPT1	5.3
Haematopoietic and lymphoid	TALL1	6.1
Haematopoietic and lymphoid	TF1	5.5
Haematopoietic and lymphoid	THP1	5.1
Haematopoietic and lymphoid	TO175T	7.2
Haematopoietic and lymphoid	TOLEDO	5.2
Haematopoietic and lymphoid	U266B1	5.7
Haematopoietic and lymphoid	U937	5.9
Haematopoietic and lymphoid	UT7	6.7
Haematopoietic and lymphoid	WSUDLCL2	6.2
Kidney	769P	5.3
Kidney	786O	5
Kidney	A498	4.4
Kidney	A704	5.2
Kidney	ACHN	4.8
Kidney	BFTC909	5
Kidney	CAKI1	5.2
Kidney	CAKI2	4.7
Kidney	CAL54	5.2
Kidney	KMRC1	4.9
Kidney	KMRC20	5
Kidney	KMRC2	5.2
Kidney	KMRC3	5.3
Kidney	OSRC2	4.8
Kidney	RCC10RGB	4.9
Kidney	SNU1272	5
Kidney	SNU349	4.6
Kidney	TUHR10TKB	4.7
Kidney	TUHR14TKB	4.9
Kidney	TUHR4TKB	4.8
Kidney	VMRCRCW	4.9
Kidney	VMRCRCZ	5.1
Large intestine	C2BBE1	5.4
Large intestine	CCK81	5.2
Large intestine	CL11	5.2
Large intestine	CL14	5.9
Large intestine	CL34	6.8
Large intestine	CL40	5.4
Large intestine	COLO205	5.3
Large intestine	COLO320	5.4
Large intestine	COLO678	6.5
Large intestine	CW2	5.4
Large intestine	DLD1	5.6
Large intestine	GP2D	5.8
Large intestine	HCC56	5.5
Large intestine	HCT116	5.5
Large intestine	HCT15	5.7
Large intestine	HS675T	5.6
Large intestine	HS698T	8.1
Large intestine	HT115	5.5
Large intestine	HT29	5.3
Large intestine	HT55	5.4
Large intestine	KM12	5.4
Large intestine	LOVO	5.1
Large intestine	LS1034	6
Large intestine	LS123	6.5
Large intestine	LS180	5.9
Large intestine	LS411N	5.9
Large intestine	LS513	5.5
Large intestine	MDST8	5.6
Large intestine	NCIH508	5.3
Large intestine	NCIH716	5.4
Large intestine	NCIH747	5.7
Large intestine	OUMS23	6.2
Large intestine	RCM1	5.6
Large intestine	RKO	5.5
Large intestine	SKCO1	5.4
Large intestine	SNU1040	5.2
Large intestine	SNU1197	5
Large intestine	SNU175	5.7
Large intestine	SNU283	5.2
Large intestine	SNU407	5.8
Large intestine	SNU503	5.4
Large intestine	SNU61	5.2
Large intestine	SNU81	6.2
Large intestine	SNUC1	5.4
Large intestine	SNUC2A	5.9
Large intestine	SNUC4	5.5
Large intestine	SNUC5	5.4
Large intestine	SW1116	5.4
Large intestine	SW1417	5.7
Large intestine	SW1463	5.1
Large intestine	SW403	5.4
Large intestine	SW480	5.6
Large intestine	SW48	5.7
Large intestine	SW620	5.2
Large intestine	SW837	5.4
Large intestine	SW948	5.1
Large intestine	T84	5.3
Liver	ALEXANDERCELLS	5
Liver	C3A	5.5
Liver	HEP3B217	5.2
Liver	HEPG2	5.3
Liver	HLE	5.6
Liver	HLF	7.1
Liver	HUH1	5.2
Liver	HUH6	5.5
Liver	HUH7	4.9
Liver	JHH1	5.6
Liver	JHH2	5.6
Liver	JHH4	5.7
Liver	JHH5	4.7
Liver	JHH6	7.4
Liver	JHH7	5.4
Liver	LI7	4.4
Liver	PLCPRF5	4.9
Liver	SKHEP1	7.1
Liver	SNU182	6.2
Liver	SNU387	5.4
Liver	SNU398	5.8
Liver	SNU423	7
Liver	SNU449	5.8
Liver	SNU475	5.6
Liver	SNU761	5
Liver	SNU878	4.8
Liver	SNU886	4.7
Lung	A549	4.8
Lung	ABC1	6.4
Lung	BEN	5
Lung	CAL12T	7.3
Lung	CALU1	5
Lung	CALU3	5
Lung	CALU6	5
Lung	CHAGOK1	5.5
Lung	COLO668	4.9
Lung	COLO699	5
Lung	CORL105	5.8
Lung	CORL23	5.9
Lung	CORL24	5.6
Lung	CORL279	4.5
Lung	CORL311	5.5
Lung	CORL47	4.7
Lung	CORL51	5.5
Lung	CORL88	5.7
Lung	CORL95	5.3
Lung	CPCN	5.7
Lung	DMS114	5
Lung	DMS153	5.3
Lung	DMS273	5.4
Lung	DMS454	5
Lung	DMS53	5.6
Lung	DMS79	5.5
Lung	DV90	5.2
Lung	EBC1	5.9
Lung	EPLC272H	6.2
Lung	HARA	5
Lung	HCC1171	5.5
Lung	HCC1195	6.2
Lung	HCC15	5.4
Lung	HCC2279	5.2
Lung	HCC2935	5.8
Lung	HCC33	5.5
Lung	HCC366	7.8
Lung	HCC4006	5.6
Lung	HCC44	5
Lung	HCC78	5.3
Lung	HCC827	5.4
Lung	HCC95	4.9
Lung	HLC1	5.1
Lung	HLFA	5.2
Lung	HS229T	5.6
Lung	HS618T	5.5
Lung	IALM	5.4
Lung	KNS62	5.3
Lung	LC1F	5
Lung	LC1SQSF	5.4
Lung	LCLC103H	6.5
Lung	LCLC97TM1	5.4
Lung	LK2	5
Lung	LOUNH91	5.2
Lung	LU65	5.5
Lung	LU99	4.9
Lung	LUDLU1	5.3
Lung	LXF289	6.1
Lung	MORCPR	5.1
Lung	NCIH1048	5.3
Lung	NCIH1092	5
Lung	NCIH1105	5.8
Lung	NCIH1155	4.8
Lung	NCIH1184	5.1
Lung	NCIH1299	5
Lung	NCIH1339	5.3
Lung	NCIH1341	5.3
Lung	NCIH1355	6.4
Lung	NCIH1373	5.2
Lung	NCIH1385	4.4
Lung	NCIH1395	4.7
Lung	NCIH1435	6.2
Lung	NCIH1436	5.6
Lung	NCIH1437	5.2
Lung	NCIH146	5.4
Lung	NCIH1563	5.4
Lung	NCIH1568	5.3
Lung	NCIH1573	5.4
Lung	NCIH1581	5.3
Lung	NCIH1618	5.5
Lung	NCIH1623	5.9
Lung	NCIH1648	5.1
Lung	NCIH1650	5.5
Lung	NCIH1651	5
Lung	NCIH1666	5.6
Lung	NCIH1693	6.2
Lung	NCIH1694	5.6
Lung	NCIH1703	5
Lung	NCIH1734	5
Lung	NCIH1755	5.2
Lung	NCIH1781	6
Lung	NCIH1792	4.4
Lung	NCIH1793	4.9
Lung	NCIH1836	5.1
Lung	NCIH1838	6.2
Lung	NCIH1869	6.3
Lung	NCIH1876	5.9
Lung	NCIH1915	4.9
Lung	NCIH1930	4.8
Lung	NCIH1944	5.1
Lung	NCIH1963	5
Lung	NCIH196	4.7
Lung	NCIH1975	6.2
Lung	NCIH2009	5.6
Lung	NCIH2023	4.7
Lung	NCIH2029	5
Lung	NCIH2030	5.7
Lung	NCIH2066	5.1
Lung	NCIH2081	4.8
Lung	NCIH2085	6.5
Lung	NCIH2087	5.5
Lung	NCIH209	5.6
Lung	NCIH2106	6.1
Lung	NCIH2110	5.1
Lung	NCIH211	5.7
Lung	NCIH2122	5.4
Lung	NCIH2126	5.5
Lung	NCIH2141	5.3
Lung	NCIH2170	4.8
Lung	NCIH2171	5.1
Lung	NCIH2172	5.6
Lung	NCIH2196	4.8
Lung	NCIH2227	5
Lung	NCIH2228	5.1
Lung	NCIH226	5.9
Lung	NCIH2286	5.1
Lung	NCIH2291	5.5
Lung	NCIH2342	6.2
Lung	NCIH2347	5.3
Lung	NCIH23	5.8
Lung	NCIH2405	5.3
Lung	NCIH2444	5.2
Lung	NCIH292	5.6
Lung	NCIH322	6.4
Lung	NCIH3255	5.7
Lung	NCIH358	4.7
Lung	NCIH441	5.7
Lung	NCIH446	4.9
Lung	NCIH460	5
Lung	NCIH510	5.6
Lung	NCIH520	5.2
Lung	NCIH522	5.8
Lung	NCIH524	4.8
Lung	NCIH526	5.3
Lung	NCIH596	5.4
Lung	NCIH647	5.4
Lung	NCIH650	5.1
Lung	NCIH661	5.1
Lung	NCIH69	5
Lung	NCIH727	5.3
Lung	NCIH810	5.2
Lung	NCIH82	5.1
Lung	NCIH838	5.6
Lung	NCIH841	5.6
Lung	NCIH854	5.4
Lung	NCIH889	5.1
Lung	PC14	5.5
Lung	RERFLCAD1	5.4
Lung	RERFLCAD2	6.4
Lung	RERFLCAI	5.5
Lung	RERFLCKJ	5.7
Lung	RERFLCMS	5.1
Lung	RERFLCSQ1	5.7
Lung	SBC5	5
Lung	SCLC21H	5.5
Lung	SHP77	4.6
Lung	SKLU1	4.7
Lung	SKMES1	5.3
Lung	SQ1	5.6
Lung	SW1271	6.1
Lung	SW1573	5.2
Lung	SW900	5.2
Lung	VMRCLCD	5.1
Lung	VMRCLCP	5.4
Oesophagus	COLO680N	5.5
Oesophagus	ECGI10	5
Oesophagus	KYSE140	5.5
Oesophagus	KYSE150	6.3
Oesophagus	KYSE180	6.2
Oesophagus	KYSE270	4.8
Oesophagus	KYSE30	6.1
Oesophagus	KYSE410	5.1
Oesophagus	KYSE450	5.5
Oesophagus	KYSE510	5.2
Oesophagus	KYSE520	4.6
Oesophagus	KYSE70	5.4
Oesophagus	OE19	5.6
Oesophagus	OE33	6.4
Oesophagus	TE10	5.7
Oesophagus	TE11	5.3
Oesophagus	TE14	5.4
Oesophagus	TE15	5.2
Oesophagus	TE1	6.6
Oesophagus	TE4	5.6
Oesophagus	TE5	5.2
Oesophagus	TE6	5.1
Oesophagus	TE8	5.6
Oesophagus	TE9	5.3
Oesophagus	TT	5.3
Ovary	59M	6
Ovary	A2780	5.3
Ovary	CAOV3	6.4
Ovary	CAOV4	5.2
Ovary	COLO704	4.9
Ovary	COV318	5.6
Ovary	COV362	5.3
Ovary	COV434	5.2
Ovary	COV504	5.5
Ovary	COV644	4.9
Ovary	EFO21	5.1
Ovary	EFO27	5.1
Ovary	ES2	5.4
Ovary	FUOV1	5.4
Ovary	HEYA8	5.1
Ovary	HS571T	8.1
Ovary	IGROV1	5.6
Ovary	JHOC5	5
Ovary	JHOM1	5.6
Ovary	JHOM2B	6.3
Ovary	JHOS2	5.2
Ovary	JHOS4	5.4
Ovary	KURAMOCHI	5.4
Ovary	MCAS	6.1
Ovary	NIHOVCAR3	6
Ovary	OAW28	5.2
Ovary	OAW42	5
Ovary	OC314	5.2
Ovary	OC316	5.3
Ovary	ONCODG1	5.4
Ovary	OV56	5.7
Ovary	OV7	7.1
Ovary	OV90	5
Ovary	OVCAR4	5.6
Ovary	OVCAR8	5.9
Ovary	OVISE	5.3
Ovary	OVK18	5.6
Ovary	OVKATE	5.2
Ovary	OVMANA	5.3
Ovary	OVSAHO	5.5
Ovary	OVTOKO	5.1
Ovary	RMGI	5.4
Ovary	RMUGS	5
Ovary	SKOV3	5.4
Ovary	SNU119	5
Ovary	SNU840	5.6
Ovary	SNU8	5.2
Ovary	TOV112D	5
Ovary	TOV21G	5.2
Ovary	TYKNU	4.9
Pancreas	ASPC1	5.3
Pancreas	BXPC3	4.6
Pancreas	CAPAN1	5.5
Pancreas	CAPAN2	5.7
Pancreas	CFPAC1	5.7
Pancreas	DANG	6.4
Pancreas	HPAC	6.4
Pancreas	HPAFII	5.1
Pancreas	HS766T	5.9
Pancreas	HUPT3	5.3
Pancreas	HUPT4	5.6
Pancreas	KCIMOH1	4.9
Pancreas	KLM1	6
Pancreas	KP2	6
Pancreas	KP3	5
Pancreas	KP4	5.5
Pancreas	L33	5.1
Pancreas	MIAPACA2	7.6
Pancreas	PANC0203	5.4
Pancreas	PANC0213	5.9
Pancreas	PANC0327	5.5
Pancreas	PANC0403	5.4
Pancreas	PANC0504	5.4
Pancreas	PANC0813	5.2
Pancreas	PANC1005	5.4
Pancreas	PANC1	5.3
Pancreas	PATU8902	5
Pancreas	PATU8988S	5.1
Pancreas	PATU8988T	6.9
Pancreas	PK1	5.6
Pancreas	PK45H	5.2
Pancreas	PK59	6.9
Pancreas	PL45	5.4
Pancreas	PSN1	5
Pancreas	QGP1	5.2
Pancreas	SNU213	6.1
Pancreas	SNU324	5.3
Pancreas	SNU410	5.8
Pancreas	SU8686	5
Pancreas	SUIT2	5
Pancreas	SW1990	5.9
Pancreas	T3M4	5
Pancreas	TCCPAN2	5
Pancreas	YAPC	5.9
Pleura	ACCMESO1	5.7
Pleura	DM3	5.5
Pleura	ISTMES1	5.8
Pleura	ISTMES2	6.5
Pleura	JL1	5.8
Pleura	MPP89	6.4
Pleura	MSTO211H	5.2
Pleura	NCIH2052	6
Pleura	NCIH2452	7.6
Pleura	NCIH28	5.2
Prostate	22RV1	4.9
Prostate	DU145	4.5
Prostate	LNCAPCLONEFGC	5.8
Prostate	MDAPCA2B	5.6
Prostate	NCIH660	5.5
Prostate	PC3	6.5
Prostate	VCAP	5.4
Salivary gland	A253	5.4
Salivary gland	YD15	6.3
Skin	A101D	5.3
Skin	A2058	5.8
Skin	A375	5.2
Skin	C32	4.9
Skin	CHL1	4.8
Skin	CJM	5.8
Skin	COLO679	5.4
Skin	COLO741	5.4
Skin	COLO783	4.9
Skin	COLO792	5.5
Skin	COLO800	5.3
Skin	COLO818	5.2
Skin	COLO829	5.5
Skin	COLO849	5.7
Skin	G361	4.7
Skin	GRM	4.8
Skin	HMCB	4.8
Skin	HS294T	5.3
Skin	HS600T	7.3
Skin	HS688AT	5.5
Skin	HS695T	4.8
Skin	HS839T	6.9
Skin	HS852T	5.7
Skin	HS895T	5.7
Skin	HS934T	6.9
Skin	HS936T	5.5
Skin	HS939T	5.4
Skin	HS940T	7.5
Skin	HS944T	5.1
Skin	HT144	5.2
Skin	IGR1	5.6
Skin	IGR37	5.2
Skin	IGR39	6.5
Skin	IPC298	6
Skin	K029AX	5.1
Skin	LOXIMVI	5.8
Skin	MALME3M	5.3
Skin	MDAMB435S	6.4
Skin	MELHO	5
Skin	MELJUSO	5.7
Skin	MEWO	6.1
Skin	RPMI7951	6
Skin	RVH421	5.7
Skin	SH4	5.6
Skin	SKMEL1	4.9
Skin	SKMEL24	5.6
Skin	SKMEL28	5.7
Skin	SKMEL2	6
Skin	SKMEL30	5.7
Skin	SKMEL31	5.5
Skin	SKMEL3	5.5
Skin	SKMEL5	5.3
Skin	UACC257	4.8
Skin	UACC62	5
Skin	WM115	5.6
Skin	WM1799	6
Skin	WM2664	5.2
Skin	WM793	6.3
Skin	WM88	5.9
Skin	WM983B	5.4
Small intestine	HUTU80	4.7
Soft tissue	A204	4.8
Soft tissue	G401	5.4
Soft tissue	G402	5.5
Soft tissue	GCT	6.6
Soft tissue	HS729	5.6
Soft tissue	HT1080	6
Soft tissue	KYM1	5.6
Soft tissue	MESSA	5.1
Soft tissue	RD	5.3
Soft tissue	RH30	4.8
Soft tissue	RH41	5.1
Soft tissue	RKN	5
Soft tissue	S117	5
Soft tissue	SJRH30	4.8
Soft tissue	SKLMS1	5.5
Soft tissue	SKUT1	5.6
Soft tissue	TE125T	8.5
Soft tissue	TE159T	8.3
Soft tissue	TE441T	5.6
Soft tissue	TE617T	5
Stomach	2313287	5.9
Stomach	AGS	5.8
Stomach	AZ521	5.2
Stomach	ECC10	5.4
Stomach	ECC12	5.1
Stomach	FU97	5.1
Stomach	GCIY	5.2
Stomach	GSS	5.7
Stomach	GSU	5.4
Stomach	HGC27	5.4
Stomach	HS746T	6.1
Stomach	HUG1N	5.8
Stomach	IM95	5.7
Stomach	KATOIII	5
Stomach	KE39	5.4
Stomach	LMSU	5.9
Stomach	MKN1	6.5
Stomach	MKN45	5.7
Stomach	MKN74	7.1
Stomach	MKN7	7.1
Stomach	NCCSTCK140	5.1
Stomach	NCIN87	6.1
Stomach	NUGC2	5.6
Stomach	NUGC3	6.1
Stomach	NUGC4	5.1
Stomach	OCUM1	5.8
Stomach	RERFGC1B	6.5
Stomach	SH10TC	4.9
Stomach	SNU16	5.9
Stomach	SNU1	5.3
Stomach	SNU216	6.5
Stomach	SNU520	5.9
Stomach	SNU5	5.2
Stomach	SNU601	5.4
Stomach	SNU620	5.4
Stomach	SNU668	7.1
Stomach	SNU719	5.9
Stomach	TGBC11TKB	5.3
Thyroid	8305C	4.8
Thyroid	8505C	7
Thyroid	BCPAP	5
Thyroid	BHT101	5.1
Thyroid	CAL62	5.2
Thyroid	CGTHW1	5
Thyroid	FTC133	6.9
Thyroid	FTC238	5.1
Thyroid	ML1	5.6
Thyroid	SW579	5.5
Thyroid	TT2609C02	4.8
Thyroid	TT	6.4
Upper aerodigestive tract	BHY	5.2
Upper aerodigestive tract	BICR16	5.1
Upper aerodigestive tract	BICR18	5.7
Upper aerodigestive tract	BICR22	5.9
Upper aerodigestive tract	BICR31	5.8
Upper aerodigestive tract	BICR56	6.1
Upper aerodigestive tract	BICR6	6
Upper aerodigestive tract	CAL27	5.6
Upper aerodigestive tract	CAL33	5.5
Upper aerodigestive tract	DETROIT562	5.2
Upper aerodigestive tract	FADU	5.7
Upper aerodigestive tract	HS840T	6.4
Upper aerodigestive tract	HSC2	5.5
Upper aerodigestive tract	HSC3	6.2
Upper aerodigestive tract	HSC4	5.5
Upper aerodigestive tract	PECAPJ15	5.2
Upper aerodigestive tract	PECAPJ34CLONEC12	5.4
Upper aerodigestive tract	PECAPJ41CLONED2	6.1
Upper aerodigestive tract	PECAPJ49	5.3
Upper aerodigestive tract	SCC15	5.2
Upper aerodigestive tract	SCC25	5.7
Upper aerodigestive tract	SCC4	6.6
Upper aerodigestive tract	SCC9	6.5
Upper aerodigestive tract	SNU1076	5.2
Upper aerodigestive tract	SNU1214	4.8
Upper aerodigestive tract	SNU46	5.4
Upper aerodigestive tract	SNU899	5.2
Upper aerodigestive tract	YD10B	5.7
Upper aerodigestive tract	YD38	6
Upper aerodigestive tract	YD8	6.7
Urinary tract	5637	5.2
Urinary tract	639V	5.3
Urinary tract	647V	5.7
Urinary tract	BC3C	5.7
Urinary tract	BFTC905	5.6
Urinary tract	CAL29	5.3
Urinary tract	HS172T	5.5
Urinary tract	HT1197	5.9
Urinary tract	HT1376	5.7
Urinary tract	J82	5.3
Urinary tract	JMSU1	6.2
Urinary tract	KMBC2	5.5
Urinary tract	KU1919	6.1
Urinary tract	RT11284	5.5
Urinary tract	RT112	5.1
Urinary tract	RT4	5
Urinary tract	SCABER	5.9
Urinary tract	SW1710	5.6
Urinary tract	SW780	5.2
Urinary tract	T24	4.9
Urinary tract	TCCSUP	5.9
Urinary tract	UMUC1	5.2
Urinary tract	UMUC3	5.1
Urinary tract	VMCUB1	5.7

> The Human Protein Atlas (HPA)

[ TOP ]

Tissue	Expression Level (TPM)
Adipose tissue	2
Adrenal gland	2.3
Appendix	3.2
Bone marrow	1.9
Breast	4.1
Cerebral cortex	5
Cervix, uterine	4.5
Colon	2.7
Duodenum	2.4
Endometrium	5.4
Epididymis	2
Esophagus	5.1
Fallopian tube	4.9
Gallbladder	4.1
Heart muscle	1.9
Kidney	3.2
Liver	1.5
Lung	4.1
Lymph node	3.8
Ovary	5.4
Pancreas	0.5
Parathyroid gland	10
Placenta	5
Prostate	4.4
Rectum	3.3
Salivary gland	1.1
Seminal vesicle	3.4
Skeletal muscle	0.8
Skin	4.4
Small intestine	3.2
Smooth muscle	3.2
Spleen	4.5
Stomach	2.7
Testis	10
Thyroid gland	7.4
Tonsil	3.6
Urinary bladder	4.2

> Text Mining based Expression

[ TOP ]

PMID	Expression	Cancer	Evidence
26344056	underexpression	Familial Colorectal Carcinoma	A detailed analysis of immortalized patient-derived B cells that contained variants in the Werner syndrome, RecQ helicase-like gene (WRN, encoding T705I), and excision repair cross-complementation group 6 (ERCC6, encoding N180Y) showed reduced levels of these proteins and increased DSBs, compared with B cells from controls.
24475022	altered expression	Colorectal Carcinoma	The most amplified markers were CD248, ERCC6, ERGIC3, GNAS, MMP2, NF1, P2RX7, SFRS6, SLC29A1 and TBX22.
16951227	altered expression	Colorectal Carcinoma	Tumor-normal differential expression was found in 13 of 20 DNA repair pathway genes (only XPA had a lower RNA level in the tumor samples; the other 12 genes had significantly higher tumor levels, all P<0.01). Coordinated expression of ERCC6, HMG1, MSH2, and POLB (RS>or=0.60) was observed in the tumor tissues (all P<0.001).
11900225	underexpression	Head and Neck Squamous Cell Carcinoma	Reduced expression of ERCC1, XPB/ERCC3, XPG/ERCC5, and CSB/ERCC6 is associated with a more than two-fold increased risk of SCCHN.
10910954	underexpression	Lung Carcinoma	We observed a 12.2 and 12.5% decrease in the baseline expression levels of XPG/ERCC5 and CSB/ERCC6, respectively, in cases compared with controls.
28665687	overexpression	Colorectal Carcinoma	ERCC6 was upregulated in CRC tissues compared to matched noncancerous adjacent tissues and was also upregulated in patients who were resistant to 5-FU treatment.

Summary
Symbol	ERCC6
Name	ERCC excision repair 6, chromatin remodeling factor
Aliases	RAD26; ARMD5; Cockayne syndrome B protein; CKN2; excision repair cross-complementing rodent repair deficienc ......
Location	10q11.23
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Somatic copy number alteration in primary tomur tissue

> The Cancer Genome Atlas (TCGA)

[ TOP ]

Correlation between expression and SCNA as well as percentage of patients in different status.

Cancer	Full Name	# Sample	R	P	% Loss	% Neutral	% Gain	Status
BLCA	Bladder urothelial carcinoma	404	0.46	1.53e-22	28.7	54.7	16.6	Neutral
BRCA	Breast invasive carcinoma	1075	0.334	1.72e-29	20.7	64.9	14.3	Neutral
CESC	Cervical and endocervical cancers	292	0.418	8.26e-14	24.7	68.8	6.5	Neutral
COAD	Colon adenocarcinoma	449	0.243	1.83e-07	18.7	76.2	5.1	Neutral
ESCA	Esophageal carcinoma	183	0.507	2.41e-13	23.5	54.6	21.9	Neutral
GBM	Glioblastoma multiforme	147	0.415	1.79e-07	90.5	9.5	0	Loss
HNSC	Head and Neck squamous cell carcinoma	514	0.352	1.91e-16	23.9	66.7	9.3	Neutral
KIRC	Kidney renal clear cell carcinoma	525	0.287	1.96e-11	15.4	82.1	2.5	Neutral
KIRP	Kidney renal papillary cell carcinoma	288	0.204	0.00049	6.2	91.3	2.4	Neutral
LAML	Acute Myeloid Leukemia	166	0.2	0.00985	1.2	97	1.8	Neutral
LGG	Brain Lower Grade Glioma	513	0.395	1.45e-20	18.1	79.9	1.9	Neutral
LIHC	Liver hepatocellular carcinoma	364	0.273	1.2e-07	17.6	70.3	12.1	Neutral
LUAD	Lung adenocarcinoma	512	0.467	3.69e-29	23.8	58	18.2	Neutral
LUSC	Lung squamous cell carcinoma	498	0.488	3.31e-31	42.8	43.4	13.9	Loss
OV	Ovarian serous cystadenocarcinoma	300	0.535	1.38e-23	26	50.7	23.3	Neutral
PAAD	Pancreatic adenocarcinoma	177	0.266	0.00035	15.8	77.4	6.8	Neutral
PCPG	Pheochromocytoma and Paraganglioma	162	0.024	0.763	0.6	93.8	5.6	Neutral
PRAD	Prostate adenocarcinoma	491	0.307	3.49e-12	11.4	85.5	3.1	Neutral
READ	Rectum adenocarcinoma	164	0.31	5.21e-05	19.5	76.2	4.3	Neutral
SARC	Sarcoma	255	0.493	4.84e-17	45.9	47.8	6.3	Loss
SKCM	Skin Cutaneous Melanoma	367	0.444	3.54e-19	59.1	39.2	1.6	Loss
STAD	Stomach adenocarcinoma	413	0.386	4.32e-16	15	67.3	17.7	Neutral
TGCT	Testicular Germ Cell Tumors	150	0.384	1.22e-06	53.3	42	4.7	Loss
THCA	Thyroid carcinoma	497	0.218	8.79e-07	2	97.6	0.4	Neutral
THYM	Thymoma	119	0.029	0.758	1.7	96.6	1.7	Neutral
UCEC	Uterine Corpus Endometrial Carcinoma	537	0.409	4.22e-23	8.2	70.6	21.2	Neutral

Summary
Symbol	ERCC6
Name	ERCC excision repair 6, chromatin remodeling factor
Aliases	RAD26; ARMD5; Cockayne syndrome B protein; CKN2; excision repair cross-complementing rodent repair deficienc ......
Location	10q11.23
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Methylation level in the promoter region of CR

> Methylation level in the promoter region of CR

[ TOP ]

Correlation between expression and methylation as well as differential methylation analysis.

Cancer	Full Name	R	P	# N	# T	Delta beta (T vs N)	P value (T vs N)	Status
BLCA	Bladder urothelial carcinoma	-0.174	0.000308	17	408	-0.001	0.888	NS/NA
BRCA	Breast invasive carcinoma	-0.219	8.17e-11	83	785	0.001	0.000169	NS/NA
CESC	Cervical and endocervical cancers	-0.259	4.36e-06	3	306	NA	NA	NS/NA
COAD	Colon adenocarcinoma	-0.172	0.00218	19	297	0.002	0.0435	NS/NA
ESCA	Esophageal carcinoma	-0.308	1.37e-05	9	185	NA	NA	NS/NA
GBM	Glioblastoma multiforme	-0.484	5.44e-05	1	64	NA	NA	NS/NA
HNSC	Head and Neck squamous cell carcinoma	-0.195	5e-06	20	522	0.002	2.63e-07	NS/NA
KIRC	Kidney renal clear cell carcinoma	-0.172	0.00137	24	319	0.003	7.59e-08	NS/NA
KIRP	Kidney renal papillary cell carcinoma	-0.304	9.58e-08	23	275	0.002	0.956	NS/NA
LAML	Acute Myeloid Leukemia	-0.249	0.00108	0	170	NA	NA	NS/NA
LGG	Brain Lower Grade Glioma	-0.16	0.000221	0	530	NA	NA	NS/NA
LIHC	Liver hepatocellular carcinoma	-0.162	0.000977	41	373	0.004	1.78e-07	NS/NA
LUAD	Lung adenocarcinoma	-0.052	0.258	21	456	-0.005	0.863	NS/NA
LUSC	Lung squamous cell carcinoma	-0.271	1.02e-07	8	370	NA	NA	NS/NA
OV	Ovarian serous cystadenocarcinoma	-0.6	0.0968	0	9	NA	NA	NS/NA
PAAD	Pancreatic adenocarcinoma	-0.066	0.373	4	179	NA	NA	NS/NA
PCPG	Pheochromocytoma and Paraganglioma	-0.159	0.0295	3	184	NA	NA	NS/NA
PRAD	Prostate adenocarcinoma	-0.19	1.06e-05	35	498	0.001	0.0191	NS/NA
READ	Rectum adenocarcinoma	-0.165	0.0998	2	99	NA	NA	NS/NA
SARC	Sarcoma	-0.398	2.82e-11	0	263	NA	NA	NS/NA
SKCM	Skin Cutaneous Melanoma	-0.316	2.95e-12	1	471	NA	NA	NS/NA
STAD	Stomach adenocarcinoma	-0.304	2.53e-09	0	372	NA	NA	NS/NA
TGCT	Testicular Germ Cell Tumors	-0.766	0	0	156	NA	NA	NS/NA
THCA	Thyroid carcinoma	-0.09	0.0325	50	509	-0.001	0.214	NS/NA
THYM	Thymoma	-0.459	1.45e-07	2	120	NA	NA	NS/NA
UCEC	Uterine Corpus Endometrial Carcinoma	-0.222	1.5e-06	34	431	-0.003	0.0165	NS/NA

Summary
Symbol	ERCC6
Name	ERCC excision repair 6, chromatin remodeling factor
Aliases	RAD26; ARMD5; Cockayne syndrome B protein; CKN2; excision repair cross-complementing rodent repair deficienc ......
Location	10q11.23
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Primary tumor tissue from TCGA > Normal tumor tissue from HPA

>The Cancer Genome Atlas (TCGA) [ TOP ]
There is no record.

> The Human Protein Atlas (HPA) [ TOP ]
There is no antibody staining data.

Summary
Symbol	ERCC6
Name	ERCC excision repair 6, chromatin remodeling factor
Aliases	RAD26; ARMD5; Cockayne syndrome B protein; CKN2; excision repair cross-complementing rodent repair deficienc ......
Location	10q11.23
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Association between expresson and subtype > Overall survival analysis based on expression > Association between expresson and stage > Association between expresson and grade

> Subtype

[ TOP ]

Association between expresson and subtype.

Cancer	Full Name	# Patients	P Value (Kruskal-Wallis)	Association	Source
BLCA	Bladder urothelial carcinoma	128	0.131	NS	24476821
BRCA	Breast invasive carcinoma	521	0.35	NS	23000897
COAD	Colon adenocarcinoma	149	0.0603	NS	22810696
GBM	Glioblastoma multiforme	157	0.0404	Significant	26824661
HNSC	Head and Neck squamous cell carcinoma	279	0.000135	Significant	25631445
KIRP	Kidney renal papillary cell carcinoma	161	0.444	NS	26536169
LGG	Brain Lower Grade Glioma	513	4.42e-09	Significant	26824661
LUAD	Lung adenocarcinoma	230	0.292	NS	25079552
LUSC	Lung squamous cell carcinoma	178	0.129	NS	22960745
OV	Ovarian serous cystadenocarcinoma	287	0.0463	Significant	21720365
PRAD	Prostate adenocarcinoma	333	1.17e-06	Significant	26544944
READ	Rectum adenocarcinoma	67	0.484	NS	22810696
SKCM	Skin Cutaneous Melanoma	315	6.53e-10	Significant	26091043
STAD	Stomach adenocarcinoma	277	0.65	NS	25079317
THCA	Thyroid carcinoma	391	1.71e-10	Significant	25417114
UCEC	Uterine Corpus Endometrial Carcinoma	232	0.112	NS	23636398

> Overall survival

[ TOP ]

Overall survival analysis based on expression.

Cancer	Full Name	# Patients	Hazard Ratio	P Value (Log Rank Test)	Association
BLCA	Bladder urothelial carcinoma	405	0.843	0.409	NS
BRCA	Breast invasive carcinoma	1079	1.886	0.00673	Shorter
CESC	Cervical and endocervical cancers	291	1.339	0.406	NS
COAD	Colon adenocarcinoma	439	1.352	0.289	NS
ESCA	Esophageal carcinoma	184	1.16	0.653	NS
GBM	Glioblastoma multiforme	158	0.84	0.489	NS
HNSC	Head and Neck squamous cell carcinoma	518	1.331	0.152	NS
KIRC	Kidney renal clear cell carcinoma	531	0.747	0.186	NS
KIRP	Kidney renal papillary cell carcinoma	287	1.509	0.343	NS
LAML	Acute Myeloid Leukemia	149	1.047	0.874	NS
LGG	Brain Lower Grade Glioma	511	0.586	0.029	Longer
LIHC	Liver hepatocellular carcinoma	365	0.908	0.678	NS
LUAD	Lung adenocarcinoma	502	1.052	0.808	NS
LUSC	Lung squamous cell carcinoma	494	1.006	0.976	NS
OV	Ovarian serous cystadenocarcinoma	303	1.435	0.0737	NS
PAAD	Pancreatic adenocarcinoma	177	1.342	0.314	NS
PCPG	Pheochromocytoma and Paraganglioma	179	2.376	0.466	NS
PRAD	Prostate adenocarcinoma	497	3.162	0.394	NS
READ	Rectum adenocarcinoma	159	1.022	0.971	NS
SARC	Sarcoma	259	1.079	0.781	NS
SKCM	Skin Cutaneous Melanoma	459	1.162	0.434	NS
STAD	Stomach adenocarcinoma	388	0.607	0.0315	Longer
TGCT	Testicular Germ Cell Tumors	134	0.56	0.632	NS
THCA	Thyroid carcinoma	500	0.929	0.917	NS
THYM	Thymoma	119	0.952	0.953	NS
UCEC	Uterine Corpus Endometrial Carcinoma	543	1.509	0.152	NS

> Stage

[ TOP ]

Association between expresson and stage.

Cancer	Full Name	# Patients	R Value (Spearman)	P Value (Spearman)	Association
BLCA	Bladder urothelial carcinoma	406	-0.02	0.687	NS
BRCA	Breast invasive carcinoma	1071	0.002	0.943	NS
CESC	Cervical and endocervical cancers	167	0.065	0.406	NS
COAD	Colon adenocarcinoma	445	-0.048	0.314	NS
ESCA	Esophageal carcinoma	162	-0.107	0.177	NS
HNSC	Head and Neck squamous cell carcinoma	448	-0.022	0.643	NS
KIRC	Kidney renal clear cell carcinoma	531	-0.139	0.00133	Lower
KIRP	Kidney renal papillary cell carcinoma	260	0.046	0.463	NS
LIHC	Liver hepatocellular carcinoma	347	0.013	0.803	NS
LUAD	Lung adenocarcinoma	507	0.042	0.35	NS
LUSC	Lung squamous cell carcinoma	497	0.089	0.0468	Higher
OV	Ovarian serous cystadenocarcinoma	302	0.042	0.462	NS
PAAD	Pancreatic adenocarcinoma	176	0.038	0.62	NS
READ	Rectum adenocarcinoma	156	0.059	0.461	NS
SKCM	Skin Cutaneous Melanoma	410	-0.051	0.299	NS
STAD	Stomach adenocarcinoma	392	-0.024	0.64	NS
TGCT	Testicular Germ Cell Tumors	81	-0.387	0.000354	Lower
THCA	Thyroid carcinoma	499	0.021	0.639	NS
UCEC	Uterine Corpus Endometrial Carcinoma	501	-0.066	0.14	NS

> Grade

[ TOP ]

Association between expresson and grade.

Cancer	Full Name	# Patients	R Value (Spearman)	P Value (Spearman)	Association
CESC	Cervical and endocervical cancers	272	-0.037	0.538	NS
HNSC	Head and Neck squamous cell carcinoma	498	-0.159	0.000364	Lower
KIRC	Kidney renal clear cell carcinoma	525	-0.152	0.000487	Lower
LGG	Brain Lower Grade Glioma	514	-0.104	0.0184	Lower
LIHC	Liver hepatocellular carcinoma	366	-0.013	0.8	NS
OV	Ovarian serous cystadenocarcinoma	296	0.031	0.593	NS
PAAD	Pancreatic adenocarcinoma	176	-0.028	0.709	NS
STAD	Stomach adenocarcinoma	406	-0.102	0.0395	Lower
UCEC	Uterine Corpus Endometrial Carcinoma	534	-0.033	0.441	NS

Summary
Symbol	ERCC6
Name	ERCC excision repair 6, chromatin remodeling factor
Aliases	RAD26; ARMD5; Cockayne syndrome B protein; CKN2; excision repair cross-complementing rodent repair deficienc ......
Location	10q11.23
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Targets inferred by reverse engineering method > Targets identified by ChIP-seq data

> Targets inferred by reverse engineering method [ TOP ]

> Targets identified by ChIP-seq data [ TOP ]

Summary
Symbol	ERCC6
Name	ERCC excision repair 6, chromatin remodeling factor
Aliases	RAD26; ARMD5; Cockayne syndrome B protein; CKN2; excision repair cross-complementing rodent repair deficienc ......
Location	10q11.23
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Drugs from DrugBank database

> Drugs from DrugBank database [ TOP ]
There is no record for ERCC6.

Summary
Symbol	ERCC6
Name	ERCC excision repair 6, chromatin remodeling factor
Aliases	RAD26; ARMD5; Cockayne syndrome B protein; CKN2; excision repair cross-complementing rodent repair deficienc ......
Location	10q11.23
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Protein-Protein Interaction Network > miRNA Regulatory Relationship > Interactions from Text Mining

> Protein-Protein Interaction Network [ TOP ]

> miRNA Regulatory Relationship [ TOP ]

> Interactions from Text Mining [ TOP ]
There is no record for ERCC6.