Browse HDAC4 in pancancer

Summary
SymbolHDAC4
Namehistone deacetylase 4
Aliases KIAA0288; HDAC-A; HDACA; HD4; HA6116; HDAC-4; BDMR; brachydactyly-mental retardation syndrome; AHO3; histone ......
Location2q37.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content > Domain, Function and Classification
> Gene Ontology
> KEGG and Reactome Pathway
> Domain, Function and Classification
 
Domain PF12203 Glutamine rich N terminal domain of histone deacetylase 4
PF00850 Histone deacetylase domain
Function

Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in muscle maturation via its interaction with the myocyte enhancer factors such as MEF2A, MEF2C and MEF2D. Involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer. Deacetylates HSPA1A and HSPA1B at 'Lys-77' leading to their preferential binding to co-chaperone STUB1 (PubMed:27708256).

Classification
Class Modification Substrate Product PubMed
Histone modification erase Histone acetylation H2AKac, H2BKac, H3Kac, H4Kac H2AK, H2BK, H3K, H4K 10220385
> Gene Ontology
 
Biological Process GO:0001501 skeletal system development
GO:0001503 ossification
GO:0001649 osteoblast differentiation
GO:0002076 osteoblast development
GO:0002521 leukocyte differentiation
GO:0003012 muscle system process
GO:0003013 circulatory system process
GO:0003015 heart process
GO:0003299 muscle hypertrophy in response to stress
GO:0003300 cardiac muscle hypertrophy
GO:0006090 pyruvate metabolic process
GO:0006091 generation of precursor metabolites and energy
GO:0006096 glycolytic process
GO:0006109 regulation of carbohydrate metabolic process
GO:0006110 regulation of glycolytic process
GO:0006140 regulation of nucleotide metabolic process
GO:0006165 nucleoside diphosphate phosphorylation
GO:0006338 chromatin remodeling
GO:0006476 protein deacetylation
GO:0006732 coenzyme metabolic process
GO:0006733 oxidoreduction coenzyme metabolic process
GO:0006757 ATP generation from ADP
GO:0006936 muscle contraction
GO:0006937 regulation of muscle contraction
GO:0006941 striated muscle contraction
GO:0006942 regulation of striated muscle contraction
GO:0007517 muscle organ development
GO:0007519 skeletal muscle tissue development
GO:0008015 blood circulation
GO:0008016 regulation of heart contraction
GO:0009116 nucleoside metabolic process
GO:0009118 regulation of nucleoside metabolic process
GO:0009119 ribonucleoside metabolic process
GO:0009123 nucleoside monophosphate metabolic process
GO:0009126 purine nucleoside monophosphate metabolic process
GO:0009132 nucleoside diphosphate metabolic process
GO:0009135 purine nucleoside diphosphate metabolic process
GO:0009141 nucleoside triphosphate metabolic process
GO:0009144 purine nucleoside triphosphate metabolic process
GO:0009150 purine ribonucleotide metabolic process
GO:0009161 ribonucleoside monophosphate metabolic process
GO:0009167 purine ribonucleoside monophosphate metabolic process
GO:0009179 purine ribonucleoside diphosphate metabolic process
GO:0009185 ribonucleoside diphosphate metabolic process
GO:0009199 ribonucleoside triphosphate metabolic process
GO:0009205 purine ribonucleoside triphosphate metabolic process
GO:0009612 response to mechanical stimulus
GO:0009894 regulation of catabolic process
GO:0009895 negative regulation of catabolic process
GO:0010591 regulation of lamellipodium assembly
GO:0010592 positive regulation of lamellipodium assembly
GO:0010675 regulation of cellular carbohydrate metabolic process
GO:0010677 negative regulation of cellular carbohydrate metabolic process
GO:0010830 regulation of myotube differentiation
GO:0010832 negative regulation of myotube differentiation
GO:0010882 regulation of cardiac muscle contraction by calcium ion signaling
GO:0014706 striated muscle tissue development
GO:0014812 muscle cell migration
GO:0014854 response to inactivity
GO:0014870 response to muscle inactivity
GO:0014874 response to stimulus involved in regulation of muscle adaptation
GO:0014877 response to muscle inactivity involved in regulation of muscle adaptation
GO:0014887 cardiac muscle adaptation
GO:0014888 striated muscle adaptation
GO:0014894 response to denervation involved in regulation of muscle adaptation
GO:0014896 muscle hypertrophy
GO:0014897 striated muscle hypertrophy
GO:0014898 cardiac muscle hypertrophy in response to stress
GO:0014902 myotube differentiation
GO:0014904 myotube cell development
GO:0014909 smooth muscle cell migration
GO:0014910 regulation of smooth muscle cell migration
GO:0014911 positive regulation of smooth muscle cell migration
GO:0016052 carbohydrate catabolic process
GO:0016202 regulation of striated muscle tissue development
GO:0016570 histone modification
GO:0016575 histone deacetylation
GO:0016925 protein sumoylation
GO:0018205 peptidyl-lysine modification
GO:0019362 pyridine nucleotide metabolic process
GO:0019722 calcium-mediated signaling
GO:0019932 second-messenger-mediated signaling
GO:0030031 cell projection assembly
GO:0030032 lamellipodium assembly
GO:0030098 lymphocyte differentiation
GO:0030183 B cell differentiation
GO:0030278 regulation of ossification
GO:0030279 negative regulation of ossification
GO:0030335 positive regulation of cell migration
GO:0031346 positive regulation of cell projection organization
GO:0033002 muscle cell proliferation
GO:0033233 regulation of protein sumoylation
GO:0033235 positive regulation of protein sumoylation
GO:0034612 response to tumor necrosis factor
GO:0034983 peptidyl-lysine deacetylation
GO:0035601 protein deacylation
GO:0040017 positive regulation of locomotion
GO:0040029 regulation of gene expression, epigenetic
GO:0042113 B cell activation
GO:0042278 purine nucleoside metabolic process
GO:0042326 negative regulation of phosphorylation
GO:0042493 response to drug
GO:0042692 muscle cell differentiation
GO:0043393 regulation of protein binding
GO:0043433 negative regulation of sequence-specific DNA binding transcription factor activity
GO:0043467 regulation of generation of precursor metabolites and energy
GO:0043470 regulation of carbohydrate catabolic process
GO:0043500 muscle adaptation
GO:0043502 regulation of muscle adaptation
GO:0043523 regulation of neuron apoptotic process
GO:0043525 positive regulation of neuron apoptotic process
GO:0044057 regulation of system process
GO:0044089 positive regulation of cellular component biogenesis
GO:0044262 cellular carbohydrate metabolic process
GO:0044723 single-organism carbohydrate metabolic process
GO:0044724 single-organism carbohydrate catabolic process
GO:0045667 regulation of osteoblast differentiation
GO:0045668 negative regulation of osteoblast differentiation
GO:0045820 negative regulation of glycolytic process
GO:0045912 negative regulation of carbohydrate metabolic process
GO:0045978 negative regulation of nucleoside metabolic process
GO:0045980 negative regulation of nucleotide metabolic process
GO:0046031 ADP metabolic process
GO:0046034 ATP metabolic process
GO:0046128 purine ribonucleoside metabolic process
GO:0046496 nicotinamide nucleotide metabolic process
GO:0046939 nucleotide phosphorylation
GO:0048634 regulation of muscle organ development
GO:0048641 regulation of skeletal muscle tissue development
GO:0048659 smooth muscle cell proliferation
GO:0048660 regulation of smooth muscle cell proliferation
GO:0048661 positive regulation of smooth muscle cell proliferation
GO:0048741 skeletal muscle fiber development
GO:0048742 regulation of skeletal muscle fiber development
GO:0048747 muscle fiber development
GO:0051090 regulation of sequence-specific DNA binding transcription factor activity
GO:0051091 positive regulation of sequence-specific DNA binding transcription factor activity
GO:0051098 regulation of binding
GO:0051146 striated muscle cell differentiation
GO:0051147 regulation of muscle cell differentiation
GO:0051148 negative regulation of muscle cell differentiation
GO:0051153 regulation of striated muscle cell differentiation
GO:0051154 negative regulation of striated muscle cell differentiation
GO:0051186 cofactor metabolic process
GO:0051193 regulation of cofactor metabolic process
GO:0051195 negative regulation of cofactor metabolic process
GO:0051196 regulation of coenzyme metabolic process
GO:0051198 negative regulation of coenzyme metabolic process
GO:0051272 positive regulation of cellular component movement
GO:0051402 neuron apoptotic process
GO:0055001 muscle cell development
GO:0055002 striated muscle cell development
GO:0055117 regulation of cardiac muscle contraction
GO:0060047 heart contraction
GO:0060048 cardiac muscle contraction
GO:0060491 regulation of cell projection assembly
GO:0060537 muscle tissue development
GO:0060538 skeletal muscle organ development
GO:0070555 response to interleukin-1
GO:0070932 histone H3 deacetylation
GO:0070933 histone H4 deacetylation
GO:0070997 neuron death
GO:0071107 response to parathyroid hormone
GO:0071214 cellular response to abiotic stimulus
GO:0071260 cellular response to mechanical stimulus
GO:0071356 cellular response to tumor necrosis factor
GO:0071374 cellular response to parathyroid hormone stimulus
GO:0071496 cellular response to external stimulus
GO:0072524 pyridine-containing compound metabolic process
GO:0072593 reactive oxygen species metabolic process
GO:0090257 regulation of muscle system process
GO:0097581 lamellipodium organization
GO:0098732 macromolecule deacylation
GO:1900542 regulation of purine nucleotide metabolic process
GO:1900543 negative regulation of purine nucleotide metabolic process
GO:1901214 regulation of neuron death
GO:1901216 positive regulation of neuron death
GO:1901657 glycosyl compound metabolic process
GO:1901861 regulation of muscle tissue development
GO:1902743 regulation of lamellipodium organization
GO:1902745 positive regulation of lamellipodium organization
GO:1903320 regulation of protein modification by small protein conjugation or removal
GO:1903322 positive regulation of protein modification by small protein conjugation or removal
GO:1903409 reactive oxygen species biosynthetic process
GO:1903426 regulation of reactive oxygen species biosynthetic process
GO:1903428 positive regulation of reactive oxygen species biosynthetic process
GO:1903522 regulation of blood circulation
GO:1903578 regulation of ATP metabolic process
GO:1903579 negative regulation of ATP metabolic process
GO:2000147 positive regulation of cell motility
GO:2000377 regulation of reactive oxygen species metabolic process
GO:2000379 positive regulation of reactive oxygen species metabolic process
Molecular Function GO:0001025 RNA polymerase III transcription factor binding
GO:0001047 core promoter binding
GO:0003682 chromatin binding
GO:0003714 transcription corepressor activity
GO:0004407 histone deacetylase activity
GO:0008134 transcription factor binding
GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
GO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides
GO:0017136 NAD-dependent histone deacetylase activity
GO:0019213 deacetylase activity
GO:0030955 potassium ion binding
GO:0031078 histone deacetylase activity (H3-K14 specific)
GO:0031420 alkali metal ion binding
GO:0032041 NAD-dependent histone deacetylase activity (H3-K14 specific)
GO:0033558 protein deacetylase activity
GO:0033613 activating transcription factor binding
GO:0034979 NAD-dependent protein deacetylase activity
GO:0042826 histone deacetylase binding
GO:0070491 repressing transcription factor binding
Cellular Component GO:0000118 histone deacetylase complex
GO:0015629 actin cytoskeleton
GO:0017053 transcriptional repressor complex
GO:0030016 myofibril
GO:0030017 sarcomere
GO:0030018 Z disc
GO:0031594 neuromuscular junction
GO:0031672 A band
GO:0031674 I band
GO:0042641 actomyosin
GO:0043292 contractile fiber
GO:0044449 contractile fiber part
> KEGG and Reactome Pathway
 
KEGG -
Reactome R-HSA-2894862: Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
R-HSA-2644606: Constitutive Signaling by NOTCH1 PEST Domain Mutants
R-HSA-1643685: Disease
R-HSA-5663202: Diseases of signal transduction
R-HSA-2122947: NOTCH1 Intracellular Domain Regulates Transcription
R-HSA-162582: Signal Transduction
R-HSA-157118: Signaling by NOTCH
R-HSA-1980143: Signaling by NOTCH1
R-HSA-2894858: Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer
R-HSA-2644602: Signaling by NOTCH1 PEST Domain Mutants in Cancer
R-HSA-2644603: Signaling by NOTCH1 in Cancer
Summary
SymbolHDAC4
Namehistone deacetylase 4
Aliases KIAA0288; HDAC-A; HDACA; HD4; HA6116; HDAC-4; BDMR; brachydactyly-mental retardation syndrome; AHO3; histone ......
Location2q37.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content > Mutation landscape in primary tumor tissue from TCGA
> Mutation landscape in cancer cell line from CCLE
> All mutations from COSMIC database V81
> Variations from text mining
> The Cancer Genome Atlas (TCGA)
 
> Cancer Cell Line Encyclopedia (CCLE)
 
> Catalogue of Somatic Mutations in Cancer (COSMIC)
 
COSMIC ID CDS change AA change Mutation Type Anatomical Site
COSM1406750c.1921G>Ap.V641MSubstitution - MissenseLarge_intestine
COSM1018611c.3043C>Tp.R1015CSubstitution - MissenseEndometrium
COSM4092785c.1117G>Ap.A373TSubstitution - MissenseStomach
COSM4092800c.110C>Tp.A37VSubstitution - MissenseLarge_intestine
COSM4612431c.2399delCp.P800fs*30Deletion - FrameshiftLarge_intestine
COSM418802c.1759G>Cp.E587QSubstitution - MissenseUrinary_tract
COSM5618559c.2239G>Cp.V747LSubstitution - MissenseBreast
COSM4764895c.3234G>Ap.M1078ISubstitution - MissenseStomach
COSM3407733c.2722T>Cp.L908LSubstitution - coding silentCentral_nervous_system
COSM3579795c.2185A>Tp.N729YSubstitution - MissenseSkin
COSM4570534c.2858T>Ap.F953YSubstitution - MissenseSkin
COSM3579803c.1716C>Tp.P572PSubstitution - coding silentSkin
COSM2909117c.2591G>Ap.R864HSubstitution - MissenseLarge_intestine
COSM3962595c.1863C>Tp.F621FSubstitution - coding silentLung
COSM5734782c.3091_3113del23p.L1031fs*37Deletion - FrameshiftPancreas
COSM4532456c.1886G>Ap.R629QSubstitution - MissenseSkin
COSM5941649c.718C>Tp.P240SSubstitution - MissenseSkin
COSM23303c.346C>Tp.Q116*Substitution - NonsenseSkin
COSM117346c.578A>Cp.H193PSubstitution - MissenseCentral_nervous_system
COSM3579799c.1944C>Tp.T648TSubstitution - coding silentSkin
COSM2909186c.128C>Tp.A43VSubstitution - MissenseLarge_intestine
COSM720949c.721C>Tp.L241FSubstitution - MissenseLung
COSM720953c.2781G>Tp.V927VSubstitution - coding silentLung
COSM1752461c.390C>Tp.H130HSubstitution - coding silentUrinary_tract
COSM418801c.936G>Ap.A312ASubstitution - coding silentUrinary_tract
COSM4092787c.1064C>Tp.T355MSubstitution - MissenseStomach
COSM3734204c.658G>Ap.G220RSubstitution - MissensePancreas
COSM3709522c.2373+2T>Cp.?UnknownLiver
COSM1018648c.503G>Ap.S168NSubstitution - MissenseEndometrium
COSM1406761c.155G>Ap.R52HSubstitution - MissenseCentral_nervous_system
COSM3991179c.2943T>Ap.I981ISubstitution - coding silentKidney
COSM5911660c.629C>Tp.S210FSubstitution - MissenseSkin
COSM2909183c.175C>Tp.L59LSubstitution - coding silentLarge_intestine
COSM5502647c.3193G>Cp.G1065RSubstitution - MissenseBiliary_tract
COSM5718892c.704C>Tp.A235VSubstitution - MissenseSkin
COSM2909134c.2111G>Ap.R704HSubstitution - MissenseLarge_intestine
COSM136315c.1088C>Tp.P363LSubstitution - MissenseSkin
COSM3709523c.1401G>Tp.S467SSubstitution - coding silentLiver
COSM5964145c.978+9G>Ap.?UnknownBreast
COSM4390936c.1132C>Gp.L378VSubstitution - MissenseBreast
COSM1614602c.637C>Tp.Q213*Substitution - NonsenseLiver
COSM3773957c.2361A>Gp.T787TSubstitution - coding silentKidney
COSM5461344c.955G>Ap.A319TSubstitution - MissenseLarge_intestine
COSM1692243c.2432G>Tp.G811VSubstitution - MissenseSkin
COSM1180905c.2703delCp.M902fs*55Deletion - FrameshiftLarge_intestine
COSM1482942c.2238C>Ap.F746LSubstitution - MissenseBreast
COSM720956c.3165G>Ap.T1055TSubstitution - coding silentLarge_intestine
COSM3734202c.842A>Tp.K281ISubstitution - MissensePancreas
COSM1209377c.703G>Ap.A235TSubstitution - MissenseLarge_intestine
COSM5427867c.734-7T>Cp.?UnknownHaematopoietic_and_lymphoid_tissue
COSM4960407c.2190G>Ap.R730RSubstitution - coding silentLiver
COSM4563488c.976G>Ap.E326KSubstitution - MissenseSkin
COSM5581286c.2516G>Ap.W839*Substitution - NonsenseSkin
COSM356100c.876C>Gp.C292WSubstitution - MissenseLung
COSM2909158c.1041A>Cp.T347TSubstitution - coding silentLarge_intestine
COSM1631924c.541A>Gp.N181DSubstitution - MissenseLiver
COSM5354264c.107C>Tp.T36MSubstitution - MissenseLarge_intestine
COSM4977094c.37C>Tp.R13*Substitution - NonsenseOesophagus
COSM4689682c.1696G>Tp.D566YSubstitution - MissenseLarge_intestine
COSM3743708c.3198G>Cp.V1066VSubstitution - coding silentLiver
COSM5661567c.3126G>Ap.L1042LSubstitution - coding silentSoft_tissue
COSM5436828c.1111C>Ap.Q371KSubstitution - MissenseOesophagus
COSM4955313c.1119C>Tp.A373ASubstitution - coding silentLiver
COSM5396601c.972G>Ap.P324PSubstitution - coding silentSkin
COSM3579793c.2245C>Tp.L749FSubstitution - MissenseSkin
COSM1406756c.883G>Ap.A295TSubstitution - MissenseLarge_intestine
COSM216574c.2110C>Tp.R704CSubstitution - MissensePancreas
COSM1692242c.2518G>Ap.D840NSubstitution - MissenseSkin
COSM4648554c.2937C>Tp.T979TSubstitution - coding silentLarge_intestine
COSM1018631c.1043C>Tp.S348LSubstitution - MissenseEndometrium
COSM2909133c.2116G>Ap.A706TSubstitution - MissenseLarge_intestine
COSM5946915c.866-5C>Tp.?UnknownHaematopoietic_and_lymphoid_tissue
COSM4476362c.2062C>Tp.R688CSubstitution - MissenseSkin
COSM3909972c.2799C>Tp.F933FSubstitution - coding silentSkin
COSM3579792c.2770C>Tp.P924SSubstitution - MissenseSkin
COSM2909183c.175C>Tp.L59LSubstitution - coding silentLarge_intestine
COSM1209378c.1867G>Tp.G623CSubstitution - MissenseBreast
COSM1180905c.2703delCp.M902fs*55Deletion - FrameshiftLarge_intestine
COSM1018640c.765G>Ap.R255RSubstitution - coding silentEndometrium
COSM1018617c.2613C>Tp.F871FSubstitution - coding silentEndometrium
COSM1406760c.307C>Tp.Q103*Substitution - NonsenseLarge_intestine
COSM4128245c.1675A>Tp.K559*Substitution - NonsenseOvary
COSM4628032c.1560C>Tp.S520SSubstitution - coding silentLarge_intestine
COSM1018644c.657C>Tp.S219SSubstitution - coding silentEndometrium
COSM1254007c.3038C>Tp.A1013VSubstitution - MissenseOesophagus
COSM3709528c.716T>Ap.F239YSubstitution - MissenseLiver
COSM3579808c.1271C>Tp.P424LSubstitution - MissenseSkin
COSM26918c.3073+1G>Ap.?UnknownBreast
COSM5673643c.986T>Cp.L329SSubstitution - MissenseSoft_tissue
COSM3758097c.1566G>Ap.P522PSubstitution - coding silentLarge_intestine
COSM5718892c.704C>Tp.A235VSubstitution - MissenseSkin
COSM1614600c.1144C>Ap.Q382KSubstitution - MissenseLiver
COSM4689676c.2239G>Ap.V747ISubstitution - MissenseLarge_intestine
COSM4092792c.895G>Ap.G299RSubstitution - MissenseStomach
COSM4464870c.1356C>Tp.S452SSubstitution - coding silentSkin
COSM4795363c.2834G>Ap.G945DSubstitution - MissenseLiver
COSM418800c.160G>Ap.D54NSubstitution - MissenseUrinary_tract
COSM1180905c.2703delCp.M902fs*55Deletion - FrameshiftLarge_intestine
COSM1614598c.2855-8C>Ap.?UnknownLiver
COSM3972138c.3027C>Tp.P1009PSubstitution - coding silentCentral_nervous_system
COSM5396599c.1521C>Tp.I507ISubstitution - coding silentSkin
COSM4689678c.2171G>Ap.G724DSubstitution - MissenseLarge_intestine
COSM5553713c.2130G>Cp.E710DSubstitution - MissenseProstate
COSM1018631c.1043C>Tp.S348LSubstitution - MissenseEndometrium
COSM720948c.319C>Ap.Q107KSubstitution - MissenseLung
COSM5344141c.2469G>Tp.K823NSubstitution - MissenseLarge_intestine
COSM4128244c.2938G>Ap.A980TSubstitution - MissenseOvary
COSM5449679c.2946C>Tp.C982CSubstitution - coding silentLarge_intestine
COSM1254008c.204G>Ap.E68ESubstitution - coding silentOesophagus
COSM133458c.158_159TG>ATp.L53HSubstitution - MissenseOvary
COSM2909135c.2063G>Ap.R688HSubstitution - MissenseLarge_intestine
COSM1209378c.1867G>Tp.G623CSubstitution - MissenseLarge_intestine
COSM3709522c.2373+2T>Cp.?UnknownLiver
COSM4421632c.2736A>Gp.R912RSubstitution - coding silentPleura
COSM3695375c.70C>Tp.R24CSubstitution - MissenseLarge_intestine
COSM6005874c.2690G>Tp.G897VSubstitution - MissenseSmall_intestine
COSM325480c.420G>Tp.E140DSubstitution - MissenseLung
COSM4955313c.1119C>Tp.A373ASubstitution - coding silentLiver
COSM720956c.3165G>Ap.T1055TSubstitution - coding silentLung
COSM1209379c.1654G>Ap.A552TSubstitution - MissenseLarge_intestine
COSM4092800c.110C>Tp.A37VSubstitution - MissenseStomach
COSM1018644c.657C>Tp.S219SSubstitution - coding silentLarge_intestine
COSM2909174c.599G>Ap.R200HSubstitution - MissenseLarge_intestine
COSM720952c.2223G>Ap.S741SSubstitution - coding silentLung
COSM1018638c.847C>Tp.R283CSubstitution - MissenseEndometrium
COSM720950c.1237C>Gp.L413VSubstitution - MissenseLung
COSM4689684c.954C>Tp.P318PSubstitution - coding silentLarge_intestine
COSM4092775c.2989-2A>Gp.?UnknownStomach
COSM4885315c.2653G>Cp.G885RSubstitution - MissenseUpper_aerodigestive_tract
COSM4482482c.2610C>Tp.F870FSubstitution - coding silentSkin
COSM3579806c.1447C>Tp.Q483*Substitution - NonsenseSkin
COSM5993981c.1704A>Gp.E568ESubstitution - coding silentProstate
COSM5498830c.2219-5delCp.?UnknownBiliary_tract
COSM1669897c.500C>Tp.A167VSubstitution - MissenseLarge_intestine
COSM2909154c.1197C>Ap.T399TSubstitution - coding silentLarge_intestine
COSM1018642c.724A>Gp.R242GSubstitution - MissenseEndometrium
COSM1018627c.1512G>Ap.M504ISubstitution - MissenseEndometrium
COSM4505054c.682C>Tp.P228SSubstitution - MissenseSkin
COSM1018615c.2652C>Tp.P884PSubstitution - coding silentEndometrium
COSM4446176c.2855-10C>Tp.?UnknownSkin
COSM1531244c.1548G>Ap.R516RSubstitution - coding silentLarge_intestine
COSM4410315c.443G>Ap.R148QSubstitution - MissenseOesophagus
COSM4092777c.2726C>Tp.A909VSubstitution - MissenseStomach
COSM4092781c.1802G>Ap.R601QSubstitution - MissenseStomach
COSM1614598c.2855-8C>Ap.?UnknownLiver
COSM23304c.973G>Ap.A325TSubstitution - MissenseSkin
COSM1254010c.2083C>Tp.R695WSubstitution - MissenseStomach
COSM3839024c.3184C>Tp.L1062LSubstitution - coding silentBreast
COSM1018619c.2451C>Tp.S817SSubstitution - coding silentEndometrium
COSM3962593c.2087G>Tp.G696VSubstitution - MissenseLung
COSM5471507c.111G>Ap.A37ASubstitution - coding silentLarge_intestine
COSM1531244c.1548G>Ap.R516RSubstitution - coding silentLarge_intestine
COSM1209381c.1096-1G>Tp.?UnknownLarge_intestine
COSM2909105c.3031G>Ap.A1011TSubstitution - MissenseBone
COSM1180905c.2703delCp.M902fs*55Deletion - FrameshiftLarge_intestine
COSM720954c.2837A>Gp.Y946CSubstitution - MissenseLung
COSM1254007c.3038C>Tp.A1013VSubstitution - MissenseSkin
COSM2909175c.592G>Ap.D198NSubstitution - MissenseSkin
COSM123550c.2660G>Tp.G887VSubstitution - MissenseUpper_aerodigestive_tract
COSM4513718c.948C>Tp.I316ISubstitution - coding silentSkin
COSM5951598c.1939C>Tp.P647SSubstitution - MissenseOesophagus
COSM4764898c.647C>Tp.P216LSubstitution - MissenseStomach
COSM5889707c.1349C>Tp.S450FSubstitution - MissenseSkin
COSM5617125c.1720C>Ap.R574RSubstitution - coding silentLung
COSM3909972c.2799C>Tp.F933FSubstitution - coding silentLarge_intestine
COSM5354264c.107C>Tp.T36MSubstitution - MissenseLarge_intestine
COSM1669897c.500C>Tp.A167VSubstitution - MissenseLarge_intestine
COSM1631923c.1603C>Ap.L535MSubstitution - MissenseLiver
COSM3391615c.2896G>Ap.G966SSubstitution - MissensePancreas
COSM4977007c.2842C>Gp.L948VSubstitution - MissenseOesophagus
COSM4959325c.285G>Ap.R95RSubstitution - coding silentLiver
COSM82171c.2106C>Tp.R702RSubstitution - coding silentOvary
COSM26918c.3073+1G>Ap.?UnknownBreast
COSM253734c.591C>Tp.S197SSubstitution - coding silentUrinary_tract
COSM1018625c.2303C>Tp.A768VSubstitution - MissenseEndometrium
COSM4421633c.2746A>Tp.M916LSubstitution - MissensePleura
COSM3579791c.3048C>Tp.S1016SSubstitution - coding silentSkin
COSM5396598c.2743G>Ap.V915ISubstitution - MissenseSkin
COSM1018636c.851C>Tp.P284LSubstitution - MissenseEndometrium
COSM5578690c.1031C>Tp.P344LSubstitution - MissenseSkin
COSM5715101c.3196G>Ap.V1066MSubstitution - MissenseHaematopoietic_and_lymphoid_tissue
COSM1209383c.1733C>Tp.P578LSubstitution - MissenseLarge_intestine
COSM2154943c.579C>Tp.H193HSubstitution - coding silentCentral_nervous_system
COSM3782157c.92C>Tp.T31MSubstitution - MissensePancreas
COSM1018611c.3043C>Tp.R1015CSubstitution - MissenseEndometrium
COSM5756022c.743C>Tp.P248LSubstitution - MissenseLarge_intestine
COSM5587964c.1989G>Ap.L663LSubstitution - coding silentSkin
COSM2909108c.2960C>Gp.A987GSubstitution - MissenseOesophagus
COSM4959325c.285G>Ap.R95RSubstitution - coding silentLiver
COSM216574c.2110C>Tp.R704CSubstitution - MissensePancreas
COSM4648555c.978G>Tp.E326DSubstitution - MissenseLarge_intestine
COSM5718892c.704C>Tp.A235VSubstitution - MissenseSkin
COSM3939008c.2598C>Tp.D866DSubstitution - coding silentOesophagus
COSM311722c.2577C>Tp.Y859YSubstitution - coding silentLung
COSM4133598c.1269G>Ap.P423PSubstitution - coding silentThyroid
COSM1614599c.1751G>Tp.S584ISubstitution - MissenseLiver
COSM4092789c.1029T>Cp.L343LSubstitution - coding silentStomach
COSM3728097c.2686G>Ap.G896SSubstitution - MissenseHaematopoietic_and_lymphoid_tissue
COSM720955c.2916C>Tp.L972LSubstitution - coding silentLung
COSM4092776c.2929G>Ap.D977NSubstitution - MissenseStomach
COSM4460393c.1164C>Tp.F388FSubstitution - coding silentSkin
COSM4092794c.700G>Ap.D234NSubstitution - MissenseStomach
COSM4795363c.2834G>Ap.G945DSubstitution - MissenseLiver
COSM383307c.809G>Tp.R270LSubstitution - MissenseLung
COSM3839026c.981G>Ap.T327TSubstitution - coding silentBreast
COSM320778c.1495C>Gp.Q499ESubstitution - MissenseLung
COSM1614602c.637C>Tp.Q213*Substitution - NonsenseLiver
COSM270702c.516G>Cp.K172NSubstitution - MissenseLarge_intestine
COSM2909186c.128C>Tp.A43VSubstitution - MissenseLarge_intestine
COSM1209382c.2191C>Tp.Q731*Substitution - NonsenseLarge_intestine
COSM298352c.2102_2103delTCp.I701fs*35Deletion - FrameshiftLarge_intestine
COSM4987999c.2432G>Ap.G811DSubstitution - MissenseSoft_tissue
COSM4092774c.3133G>Ap.A1045TSubstitution - MissenseStomach
COSM4646062c.271G>Ap.A91TSubstitution - MissenseLarge_intestine
COSM3579801c.1854C>Tp.P618PSubstitution - coding silentSkin
COSM2909154c.1197C>Ap.T399TSubstitution - coding silentLarge_intestine
COSM4583359c.174A>Gp.S58SSubstitution - coding silentBone
COSM3758097c.1566G>Ap.P522PSubstitution - coding silentStomach
COSM1752461c.390C>Tp.H130HSubstitution - coding silentUrinary_tract
COSM1018646c.554C>Tp.A185VSubstitution - MissenseEndometrium
COSM4092778c.2571C>Tp.V857VSubstitution - coding silentStomach
COSM5941651c.2248C>Tp.P750SSubstitution - MissenseSkin
COSM1406761c.155G>Ap.R52HSubstitution - MissenseLarge_intestine
COSM1614601c.942C>Tp.N314NSubstitution - coding silentLiver
COSM3909973c.2222C>Tp.S741LSubstitution - MissenseSkin
COSM2909158c.1041A>Cp.T347TSubstitution - coding silentLarge_intestine
COSM4651457c.2094C>Tp.C698CSubstitution - coding silentLarge_intestine
COSM4805223c.2929G>Tp.D977YSubstitution - MissenseLiver
COSM1180905c.2703delCp.M902fs*55Deletion - FrameshiftLarge_intestine
COSM5498832c.958G>Ap.V320ISubstitution - MissenseBiliary_tract
COSM4092779c.1987C>Gp.L663VSubstitution - MissenseStomach
COSM3734204c.658G>Ap.G220RSubstitution - MissensePancreas
COSM400248c.2263G>Tp.G755WSubstitution - MissenseLung
COSM477159c.253C>Gp.Q85ESubstitution - MissenseKidney
COSM32457c.2180C>Gp.P727RSubstitution - MissenseBreast
COSM5491607c.1167C>Tp.P389PSubstitution - coding silentBiliary_tract
COSM3909971c.2825C>Tp.P942LSubstitution - MissenseSkin
COSM4311302c.2314C>Tp.R772CSubstitution - MissenseSkin
COSM4912787c.1153C>Tp.L385FSubstitution - MissenseLiver
COSM4583358c.2990T>Cp.L997PSubstitution - MissenseBone
COSM3579808c.1271C>Tp.P424LSubstitution - MissenseLarge_intestine
COSM5957888c.757C>Tp.R253WSubstitution - MissenseThyroid
COSM3734202c.842A>Tp.K281ISubstitution - MissensePancreas
COSM4612431c.2399delCp.P800fs*30Deletion - FrameshiftLarge_intestine
COSM1406754c.975G>Tp.A325ASubstitution - coding silentLarge_intestine
COSM5471506c.2789C>Tp.S930LSubstitution - MissenseLarge_intestine
COSM6006267c.1792_1794delGAGp.E598delEDeletion - In frameSmall_intestine
COSM1209379c.1654G>Ap.A552TSubstitution - MissenseStomach
COSM4960407c.2190G>Ap.R730RSubstitution - coding silentLiver
COSM248951c.2801A>Gp.D934GSubstitution - MissensePancreas
COSM1018631c.1043C>Tp.S348LSubstitution - MissenseSkin
COSM2154854c.581G>Cp.C194SSubstitution - MissenseCentral_nervous_system
COSM253734c.591C>Tp.S197SSubstitution - coding silentUrinary_tract
COSM1018629c.1065G>Ap.T355TSubstitution - coding silentEndometrium
COSM1018634c.928G>Ap.V310ISubstitution - MissenseEndometrium
COSM1531244c.1548G>Ap.R516RSubstitution - coding silentLarge_intestine
COSM3709523c.1401G>Tp.S467SSubstitution - coding silentLiver
COSM1018621c.2450C>Ap.S817YSubstitution - MissenseEndometrium
COSM2909148c.1318G>Ap.A440TSubstitution - MissenseStomach
COSM3407734c.935C>Tp.A312VSubstitution - MissenseCentral_nervous_system
COSM311722c.2577C>Tp.Y859YSubstitution - coding silentSoft_tissue
COSM4464852c.1355C>Tp.S452FSubstitution - MissenseSkin
COSM5655459c.2226C>Tp.L742LSubstitution - coding silentHaematopoietic_and_lymphoid_tissue
COSM4885017c.1902C>Ap.P634PSubstitution - coding silentUpper_aerodigestive_tract
COSM1209384c.776A>Gp.K259RSubstitution - MissenseLarge_intestine
COSM4689684c.954C>Tp.P318PSubstitution - coding silentLarge_intestine
COSM1180905c.2703delCp.M902fs*55Deletion - FrameshiftLarge_intestine
COSM5205888c.845delAp.K282fs*116Deletion - FrameshiftBreast
COSM3734204c.658G>Ap.G220RSubstitution - MissensePancreas
COSM1406752c.1167delCp.G390fs*8Deletion - FrameshiftLarge_intestine
COSM4092798c.598C>Tp.R200CSubstitution - MissenseStomach
COSM4389277c.230C>Tp.A77VSubstitution - MissensePancreas
COSM1406755c.898C>Tp.P300SSubstitution - MissenseLarge_intestine
COSM1614600c.1144C>Ap.Q382KSubstitution - MissenseLiver
COSM2909106c.3017A>Gp.Q1006RSubstitution - MissenseStomach
COSM720951c.2042G>Ap.R681KSubstitution - MissenseLung
COSM1406751c.1868G>Ap.G623DSubstitution - MissenseLarge_intestine
COSM1018636c.851C>Tp.P284LSubstitution - MissenseSkin
COSM393568c.2784G>Tp.L928LSubstitution - coding silentLung
COSM253734c.591C>Tp.S197SSubstitution - coding silentUrinary_tract
COSM5042875c.2558G>Ap.S853NSubstitution - MissenseLiver
COSM298997c.705C>Tp.A235ASubstitution - coding silentLarge_intestine
COSM1406759c.312C>Tp.H104HSubstitution - coding silentLarge_intestine
COSM4689675c.2430-1G>Ap.?UnknownLarge_intestine
COSM2154961c.583A>Cp.I195LSubstitution - MissenseCentral_nervous_system
COSM128141c.414C>Tp.R138RSubstitution - coding silentUpper_aerodigestive_tract
COSM3579797c.1966C>Tp.L656FSubstitution - MissenseSkin
COSM2155743c.530A>Cp.E177ASubstitution - MissenseCentral_nervous_system
COSM1662106c.2828T>Cp.L943PSubstitution - MissenseKidney
COSM2909135c.2063G>Ap.R688HSubstitution - MissenseLarge_intestine
COSM3909973c.2222C>Tp.S741LSubstitution - MissenseAdrenal_gland
COSM5611676c.2164C>Tp.L722LSubstitution - coding silentAdrenal_gland
COSM4805223c.2929G>Tp.D977YSubstitution - MissenseLiver
COSM379677c.481G>Tp.G161CSubstitution - MissenseLung
COSM5615049c.1721G>Cp.R574PSubstitution - MissenseLung
COSM4438782c.2490C>Tp.S830SSubstitution - coding silentOesophagus
COSM308046c.1633C>Tp.P545SSubstitution - MissenseBiliary_tract
COSM1482942c.2238C>Ap.F746LSubstitution - MissenseCervix
COSM4483906c.2749C>Tp.P917SSubstitution - MissenseSkin
COSM1631924c.541A>Gp.N181DSubstitution - MissenseLiver
COSM5439742c.313G>Ap.E105KSubstitution - MissenseOesophagus
COSM4540267c.2812G>Ap.G938SSubstitution - MissenseSkin
COSM3579801c.1854C>Tp.P618PSubstitution - coding silentStomach
COSM2909113c.2804C>Tp.A935VSubstitution - MissenseLarge_intestine
COSM2909160c.998T>Cp.L333PSubstitution - MissenseLung
COSM308046c.1633C>Tp.P545SSubstitution - MissenseSkin
COSM325479c.2635G>Ap.E879KSubstitution - MissenseLung
COSM2909158c.1041A>Cp.T347TSubstitution - coding silentLarge_intestine
COSM3839026c.981G>Ap.T327TSubstitution - coding silentLarge_intestine
COSM4639123c.1118C>Tp.A373VSubstitution - MissenseLarge_intestine
COSM442597c.2306G>Ap.G769ESubstitution - MissenseBreast
COSM1614601c.942C>Tp.N314NSubstitution - coding silentLiver
COSM4311375c.412C>Tp.R138CSubstitution - MissenseCervix
COSM2909113c.2804C>Tp.A935VSubstitution - MissenseLarge_intestine
COSM4896637c.612-1G>Ap.?UnknownSkin
COSM2909111c.2900G>Ap.R967QSubstitution - MissenseLarge_intestine
COSM117346c.578A>Cp.H193PSubstitution - MissenseOvary
COSM3734202c.842A>Tp.K281ISubstitution - MissensePancreas
COSM4689680c.2137A>Gp.T713ASubstitution - MissenseLarge_intestine
COSM2155837c.528A>Gp.Q176QSubstitution - coding silentCentral_nervous_system
COSM5520109c.2498A>Cp.K833TSubstitution - MissenseBiliary_tract
COSM1285331c.2750C>Tp.P917LSubstitution - MissenseAutonomic_ganglia
COSM139439c.490+1G>Ap.?UnknownSkin
COSM4092796c.683C>Tp.P228LSubstitution - MissenseStomach
COSM5990919c.2854+2T>Gp.?UnknownProstate
COSM1018613c.2874G>Tp.K958NSubstitution - MissenseEndometrium
COSM5449680c.2393G>Ap.R798HSubstitution - MissenseLarge_intestine
COSM1018623c.2321C>Tp.A774VSubstitution - MissenseEndometrium
COSM2909159c.1017G>Ap.S339SSubstitution - coding silentLarge_intestine
COSM2154853c.582C>Tp.C194CSubstitution - coding silentCentral_nervous_system
COSM4689684c.954C>Tp.P318PSubstitution - coding silentLarge_intestine
COSM1209380c.1100C>Tp.T367MSubstitution - MissenseLarge_intestine
COSM5718892c.704C>Tp.A235VSubstitution - MissenseSkin
COSM4092773c.3208G>Ap.E1070KSubstitution - MissenseStomach
COSM418801c.936G>Ap.A312ASubstitution - coding silentUrinary_tract
COSM5973684c.1659G>Ap.Q553QSubstitution - coding silentUpper_aerodigestive_tract
COSM3709528c.716T>Ap.F239YSubstitution - MissenseLiver
COSM3668631c.3164C>Gp.T1055RSubstitution - MissenseLiver
COSM3731719c.2955G>Ap.S985SSubstitution - coding silentStomach
COSM5620936c.28C>Tp.L10FSubstitution - MissenseHaematopoietic_and_lymphoid_tissue
COSM4133597c.2565C>Tp.P855PSubstitution - coding silentThyroid
COSM1254009c.2229C>Tp.A743ASubstitution - coding silentStomach
COSM3972137c.3145G>Ap.E1049KSubstitution - MissenseCentral_nervous_system
COSM5994467c.2713G>Ap.A905TSubstitution - MissenseProstate
COSM5994467c.2713G>Ap.A905TSubstitution - MissenseProstate
> Text Mining based Variations
 
PMID Variation Cancer Evidence
17363583mutation; copy number lossMelanomaHDs were also common for PTPRD (n = 7) and HDAC4 (n = 3), TSGs recently found to be mutated or deleted in other cancer types.
Summary
SymbolHDAC4
Namehistone deacetylase 4
Aliases KIAA0288; HDAC-A; HDACA; HD4; HA6116; HDAC-4; BDMR; brachydactyly-mental retardation syndrome; AHO3; histone ......
Location2q37.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content > Post-translational modification (PTM)
> Post-translational modification (PTM)
 
 Filter By:
Uniprot ID Position Amino Acid Description Upstream Enzyme Affected By Mutation Amino Acid Sequence Variant
P56524246SPhosphoserineCaMK4 and SIK1NoNone detected
P56524350SPhosphoserine-NoNone detected
P56524467SPhosphoserineCaMK4 and SIK1NoNone detected
P56524565SPhosphoserine-NoNone detected
P56524632SPhosphoserineCaMK4NoNone detected
P56524633SPhosphoserine-NoNone detected
Summary
SymbolHDAC4
Namehistone deacetylase 4
Aliases KIAA0288; HDAC-A; HDACA; HD4; HA6116; HDAC-4; BDMR; brachydactyly-mental retardation syndrome; AHO3; histone ......
Location2q37.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content > Expression analysis in primary tumor tissue from TCGA
> Expression level in cancer cell line from CCLE
> Expression level in human normal tissue from HPA
> Text mining based expression change
> The Cancer Genome Atlas (TCGA)
 


  Differential expression analysis for cancers with more than 10 normal samples
Cancer Full Name # N # T Median (N) Median (T) LogFC Adj. P Status
BLCABladder urothelial carcinoma194084.7263.346-1.7961.4e-16Under
BRCABreast invasive carcinoma11211004.8674.012-0.9063.96e-37Under
CESCCervical and endocervical cancers33065.6224.144NANANA
COADColon adenocarcinoma414594.8934.56-0.5481.84e-09NS
ESCAEsophageal carcinoma111855.2865.236-0.5090.0777NS
GBMGlioblastoma multiforme51666.0424.827NANANA
HNSCHead and Neck squamous cell carcinoma445225.0464.5-0.5661.31e-06NS
KIRCKidney renal clear cell carcinoma725344.2673.887-0.3544.24e-07NS
KIRPKidney renal papillary cell carcinoma322914.4293.865-0.5020.000112NS
LAMLAcute Myeloid Leukemia0173NA5.874NANANA
LGGBrain Lower Grade Glioma0530NA6.365NANANA
LIHCLiver hepatocellular carcinoma503731.9392.8681.0056.94e-17Over
LUADLung adenocarcinoma595174.7154.109-0.4811.41e-06NS
LUSCLung squamous cell carcinoma515014.5644.488-0.0350.765NS
OVOvarian serous cystadenocarcinoma0307NA4.789NANANA
PAADPancreatic adenocarcinoma41794.3084.168NANANA
PCPGPheochromocytoma and Paraganglioma31845.255.033NANANA
PRADProstate adenocarcinoma524984.6814.501-0.1840.0231NS
READRectum adenocarcinoma101675.5974.664-0.8931.11e-05Under
SARCSarcoma22635.2594.468NANANA
SKCMSkin Cutaneous Melanoma14724.6525.048NANANA
STADStomach adenocarcinoma354155.5924.912-0.6784.5e-05Under
TGCTTesticular Germ Cell Tumors0156NA4.049NANANA
THCAThyroid carcinoma595094.8873.776-1.1931.73e-46Under
THYMThymoma21206.0416.368NANANA
UCECUterine Corpus Endometrial Carcinoma355465.3774.378-1.0341.03e-12Under
> Cancer Cell Line Encyclopedia (CCLE)
 



Tissue Cell Line Expression Level (Microarray)
Autonomic ganglia CHP126 7.5
Autonomic ganglia CHP212 5.9
Autonomic ganglia IMR32 6.3
Autonomic ganglia KELLY 5.9
Autonomic ganglia KPNRTBM1 7
Autonomic ganglia KPNSI9S 6.2
Autonomic ganglia KPNYN 6.5
Autonomic ganglia MHHNB11 6.6
Autonomic ganglia NB1 6.7
Autonomic ganglia NH6 6.4
Autonomic ganglia SHSY5Y 6.3
Autonomic ganglia SIMA 6.9
Autonomic ganglia SKNAS 6.1
Autonomic ganglia SKNBE2 6
Autonomic ganglia SKNDZ 6.1
Autonomic ganglia SKNFI 6.4
Autonomic ganglia SKNSH 5.6
Biliary tract HUCCT1 5.1
Biliary tract HUH28 5.9
Biliary tract SNU1079 6
Biliary tract SNU1196 8.4
Biliary tract SNU245 6.4
Biliary tract SNU308 5.6
Biliary tract SNU478 6.3
Bone 143B 6.2
Bone A673 6.6
Bone CADOES1 6.1
Bone CAL78 6.3
Bone G292CLONEA141B1 4.9
Bone HOS 5.8
Bone HS706T 5.5
Bone HS737T 5.6
Bone HS819T 5.6
Bone HS821T 5.7
Bone HS822T 5.5
Bone HS863T 5.9
Bone HS870T 5.5
Bone HS888T 5.8
Bone MG63 6.3
Bone MHHES1 7.2
Bone OUMS27 5.8
Bone RDES 6.6
Bone SJSA1 6.5
Bone SKES1 6
Bone SKNMC 6.4
Bone SW1353 5.5
Bone T173 5.3
Bone TC71 6
Bone U2OS 4.5
Breast AU565 4.9
Breast BT20 6.2
Breast BT474 6
Breast BT483 5.6
Breast BT549 5.7
Breast CAL120 6
Breast CAL148 6.2
Breast CAL51 6
Breast CAL851 5
Breast CAMA1 5.8
Breast DU4475 8
Breast EFM192A 5.2
Breast EFM19 5.7
Breast EVSAT 5.9
Breast HCC1143 5.8
Breast HCC1187 5.5
Breast HCC1395 6.5
Breast HCC1419 6
Breast HCC1428 5.8
Breast HCC1500 6.4
Breast HCC1569 6.2
Breast HCC1599 4.6
Breast HCC1806 5.6
Breast HCC1937 4.9
Breast HCC1954 5.9
Breast HCC202 5.2
Breast HCC2157 5.6
Breast HCC2218 5.9
Breast HCC38 5.7
Breast HCC70 5.7
Breast HDQP1 5.5
Breast HMC18 6.7
Breast HS274T 5.8
Breast HS281T 5.4
Breast HS343T 5.8
Breast HS578T 5.6
Breast HS606T 6
Breast HS739T 5.5
Breast HS742T 5.8
Breast JIMT1 5.3
Breast KPL1 5.8
Breast MCF7 5.4
Breast MDAMB134VI 6.2
Breast MDAMB157 5.8
Breast MDAMB175VII 5.8
Breast MDAMB231 5.8
Breast MDAMB361 6.5
Breast MDAMB415 5.1
Breast MDAMB436 7.5
Breast MDAMB453 6.7
Breast MDAMB468 6
Breast SKBR3 5.5
Breast T47D 4.8
Breast UACC812 5.2
Breast UACC893 6.6
Breast YMB1 5.7
Breast ZR751 5
Breast ZR7530 6.5
Central nervous system 1321N1 5.9
Central nervous system 42MGBA 6.3
Central nervous system 8MGBA 5.4
Central nervous system A172 6
Central nervous system AM38 5.6
Central nervous system BECKER 6.6
Central nervous system CAS1 5.5
Central nervous system CCFSTTG1 7
Central nervous system D283MED 5.7
Central nervous system D341MED 6.2
Central nervous system DAOY 5.7
Central nervous system DBTRG05MG 5.8
Central nervous system DKMG 6.1
Central nervous system GAMG 5.5
Central nervous system GB1 6
Central nervous system GI1 5.5
Central nervous system GMS10 5.2
Central nervous system GOS3 6.4
Central nervous system H4 6.8
Central nervous system HS683 5.8
Central nervous system KALS1 5.4
Central nervous system KG1C 5.1
Central nervous system KNS42 7.9
Central nervous system KNS60 5.6
Central nervous system KNS81 5.5
Central nervous system KS1 6.2
Central nervous system LN18 4.4
Central nervous system LN229 6.7
Central nervous system M059K 5.4
Central nervous system MOGGCCM 5.6
Central nervous system MOGGUVW 6
Central nervous system NMCG1 5.5
Central nervous system ONS76 4.9
Central nervous system SF126 5.5
Central nervous system SF295 5.9
Central nervous system SNB19 6.1
Central nervous system SNU1105 5.7
Central nervous system SNU201 6.1
Central nervous system SNU466 6.8
Central nervous system SNU489 5.6
Central nervous system SNU626 6
Central nervous system SNU738 5.8
Central nervous system SW1088 6
Central nervous system SW1783 5.8
Central nervous system T98G 6.3
Central nervous system TM31 6.5
Central nervous system U118MG 5.5
Central nervous system U138MG 5.8
Central nervous system U251MG 6.4
Central nervous system U87MG 6.2
Central nervous system YH13 5.7
Central nervous system YKG1 5.8
Endometrium AN3CA 6.2
Endometrium COLO684 5.4
Endometrium EFE184 5
Endometrium EN 6
Endometrium ESS1 6.1
Endometrium HEC108 5.4
Endometrium HEC151 4.9
Endometrium HEC1A 6.1
Endometrium HEC1B 7.3
Endometrium HEC251 5.9
Endometrium HEC265 6.1
Endometrium HEC50B 6.1
Endometrium HEC59 5.9
Endometrium HEC6 5.4
Endometrium ISHIKAWAHERAKLIO02ER 5.8
Endometrium JHUEM1 5.8
Endometrium JHUEM2 6.6
Endometrium JHUEM3 5.9
Endometrium KLE 5.8
Endometrium MFE280 5.6
Endometrium MFE296 6.1
Endometrium MFE319 6.3
Endometrium RL952 6.2
Endometrium SNGM 6.3
Endometrium SNU1077 5.3
Endometrium SNU685 6.1
Endometrium TEN 5.7
Haematopoietic and lymphoid 697 7
Haematopoietic and lymphoid A3KAW 4.8
Haematopoietic and lymphoid A4FUK 6.8
Haematopoietic and lymphoid ALLSIL 8.3
Haematopoietic and lymphoid AML193 7.9
Haematopoietic and lymphoid AMO1 6.8
Haematopoietic and lymphoid BCP1 6.6
Haematopoietic and lymphoid BDCM 5.1
Haematopoietic and lymphoid BL41 5.6
Haematopoietic and lymphoid BL70 5.7
Haematopoietic and lymphoid BV173 6
Haematopoietic and lymphoid CA46 5.8
Haematopoietic and lymphoid CI1 5.4
Haematopoietic and lymphoid CMK115 5.7
Haematopoietic and lymphoid CMK86 5.7
Haematopoietic and lymphoid CMK 6
Haematopoietic and lymphoid CMLT1 8.8
Haematopoietic and lymphoid COLO775 6
Haematopoietic and lymphoid DAUDI 5.6
Haematopoietic and lymphoid DB 5.1
Haematopoietic and lymphoid DEL 9
Haematopoietic and lymphoid DND41 10.2
Haematopoietic and lymphoid DOHH2 5.8
Haematopoietic and lymphoid EB1 5.5
Haematopoietic and lymphoid EB2 5.9
Haematopoietic and lymphoid EHEB 4.6
Haematopoietic and lymphoid EJM 5.4
Haematopoietic and lymphoid EM2 6.5
Haematopoietic and lymphoid EOL1 7.6
Haematopoietic and lymphoid F36P 6.4
Haematopoietic and lymphoid GA10 5.6
Haematopoietic and lymphoid GDM1 5.5
Haematopoietic and lymphoid GRANTA519 7
Haematopoietic and lymphoid HDLM2 7.1
Haematopoietic and lymphoid HDMYZ 5.8
Haematopoietic and lymphoid HEL9217 6
Haematopoietic and lymphoid HEL 6
Haematopoietic and lymphoid HH 5.1
Haematopoietic and lymphoid HL60 7.9
Haematopoietic and lymphoid HPBALL 8.3
Haematopoietic and lymphoid HS604T 5.9
Haematopoietic and lymphoid HS611T 4.7
Haematopoietic and lymphoid HS616T 5.7
Haematopoietic and lymphoid HS751T 5.5
Haematopoietic and lymphoid HT 5.4
Haematopoietic and lymphoid HTK 6.5
Haematopoietic and lymphoid HUNS1 5.5
Haematopoietic and lymphoid HUT102 7.2
Haematopoietic and lymphoid HUT78 6.2
Haematopoietic and lymphoid JEKO1 6.3
Haematopoietic and lymphoid JK1 5.6
Haematopoietic and lymphoid JM1 5.3
Haematopoietic and lymphoid JURKAT 9.1
Haematopoietic and lymphoid JURLMK1 6.1
Haematopoietic and lymphoid JVM2 4.7
Haematopoietic and lymphoid JVM3 4.5
Haematopoietic and lymphoid K562 5.9
Haematopoietic and lymphoid KARPAS299 8.4
Haematopoietic and lymphoid KARPAS422 5.5
Haematopoietic and lymphoid KARPAS620 5.8
Haematopoietic and lymphoid KASUMI1 7.4
Haematopoietic and lymphoid KASUMI2 6.3
Haematopoietic and lymphoid KASUMI6 6.3
Haematopoietic and lymphoid KCL22 7
Haematopoietic and lymphoid KE37 8.2
Haematopoietic and lymphoid KE97 5.7
Haematopoietic and lymphoid KG1 6
Haematopoietic and lymphoid KHM1B 5.4
Haematopoietic and lymphoid KIJK 7.9
Haematopoietic and lymphoid KMH2 6.9
Haematopoietic and lymphoid KMM1 6.1
Haematopoietic and lymphoid KMS11 6.3
Haematopoietic and lymphoid KMS12BM 5.6
Haematopoietic and lymphoid KMS18 6.3
Haematopoietic and lymphoid KMS20 5.7
Haematopoietic and lymphoid KMS21BM 5.7
Haematopoietic and lymphoid KMS26 6
Haematopoietic and lymphoid KMS27 5.4
Haematopoietic and lymphoid KMS28BM 5.2
Haematopoietic and lymphoid KMS34 5.7
Haematopoietic and lymphoid KO52 6.6
Haematopoietic and lymphoid KOPN8 6.8
Haematopoietic and lymphoid KU812 5.7
Haematopoietic and lymphoid KYO1 6.2
Haematopoietic and lymphoid L1236 5.3
Haematopoietic and lymphoid L363 6.4
Haematopoietic and lymphoid L428 5.5
Haematopoietic and lymphoid L540 8.5
Haematopoietic and lymphoid LAMA84 5.8
Haematopoietic and lymphoid LOUCY 6.2
Haematopoietic and lymphoid LP1 6.3
Haematopoietic and lymphoid M07E 6.1
Haematopoietic and lymphoid MC116 5.3
Haematopoietic and lymphoid ME1 5.8
Haematopoietic and lymphoid MEC1 6
Haematopoietic and lymphoid MEC2 5
Haematopoietic and lymphoid MEG01 6.1
Haematopoietic and lymphoid MHHCALL2 6
Haematopoietic and lymphoid MHHCALL3 6.7
Haematopoietic and lymphoid MHHCALL4 6.3
Haematopoietic and lymphoid MINO 6.1
Haematopoietic and lymphoid MJ 5.5
Haematopoietic and lymphoid MM1S 5.7
Haematopoietic and lymphoid MOLM13 6.4
Haematopoietic and lymphoid MOLM16 6.4
Haematopoietic and lymphoid MOLM6 6.5
Haematopoietic and lymphoid MOLP2 5.3
Haematopoietic and lymphoid MOLP8 7
Haematopoietic and lymphoid MOLT13 8.6
Haematopoietic and lymphoid MOLT16 6.4
Haematopoietic and lymphoid MOLT4 8.5
Haematopoietic and lymphoid MONOMAC1 8.2
Haematopoietic and lymphoid MONOMAC6 6.9
Haematopoietic and lymphoid MOTN1 6.3
Haematopoietic and lymphoid MUTZ5 6.3
Haematopoietic and lymphoid MV411 7.5
Haematopoietic and lymphoid NALM19 6.4
Haematopoietic and lymphoid NALM1 6.7
Haematopoietic and lymphoid NALM6 5.3
Haematopoietic and lymphoid NAMALWA 6.2
Haematopoietic and lymphoid NB4 7.5
Haematopoietic and lymphoid NCIH929 5.6
Haematopoietic and lymphoid NCO2 5.9
Haematopoietic and lymphoid NOMO1 7.5
Haematopoietic and lymphoid NUDHL1 5.9
Haematopoietic and lymphoid NUDUL1 5.8
Haematopoietic and lymphoid OCIAML2 6.9
Haematopoietic and lymphoid OCIAML3 8.1
Haematopoietic and lymphoid OCIAML5 7.4
Haematopoietic and lymphoid OCILY10 5.4
Haematopoietic and lymphoid OCILY19 7.7
Haematopoietic and lymphoid OCILY3 5
Haematopoietic and lymphoid OCIM1 5.5
Haematopoietic and lymphoid OPM2 6.2
Haematopoietic and lymphoid P12ICHIKAWA 7.9
Haematopoietic and lymphoid P31FUJ 5.9
Haematopoietic and lymphoid P3HR1 5.5
Haematopoietic and lymphoid PCM6 7
Haematopoietic and lymphoid PEER 5.9
Haematopoietic and lymphoid PF382 9.1
Haematopoietic and lymphoid PFEIFFER 5.1
Haematopoietic and lymphoid PL21 8.2
Haematopoietic and lymphoid RAJI 6
Haematopoietic and lymphoid RCHACV 6.6
Haematopoietic and lymphoid REC1 5.8
Haematopoietic and lymphoid REH 6.5
Haematopoietic and lymphoid RI1 5.4
Haematopoietic and lymphoid RL 5.1
Haematopoietic and lymphoid RPMI8226 6
Haematopoietic and lymphoid RPMI8402 8.6
Haematopoietic and lymphoid RS411 5.8
Haematopoietic and lymphoid SEM 5.9
Haematopoietic and lymphoid SET2 6.5
Haematopoietic and lymphoid SIGM5 7.8
Haematopoietic and lymphoid SKM1 6.7
Haematopoietic and lymphoid SKMM2 5.4
Haematopoietic and lymphoid SR786 9.2
Haematopoietic and lymphoid ST486 5.7
Haematopoietic and lymphoid SUDHL10 5.5
Haematopoietic and lymphoid SUDHL1 8
Haematopoietic and lymphoid SUDHL4 5.5
Haematopoietic and lymphoid SUDHL5 6
Haematopoietic and lymphoid SUDHL6 5.2
Haematopoietic and lymphoid SUDHL8 7.2
Haematopoietic and lymphoid SUPB15 6.1
Haematopoietic and lymphoid SUPHD1 7.5
Haematopoietic and lymphoid SUPM2 8.3
Haematopoietic and lymphoid SUPT11 9.7
Haematopoietic and lymphoid SUPT1 8.9
Haematopoietic and lymphoid TALL1 9.4
Haematopoietic and lymphoid TF1 6.4
Haematopoietic and lymphoid THP1 7.2
Haematopoietic and lymphoid TO175T 5.7
Haematopoietic and lymphoid TOLEDO 6
Haematopoietic and lymphoid U266B1 5.4
Haematopoietic and lymphoid U937 4.7
Haematopoietic and lymphoid UT7 5.8
Haematopoietic and lymphoid WSUDLCL2 5.2
Kidney 769P 6.3
Kidney 786O 6
Kidney A498 6.6
Kidney A704 5.4
Kidney ACHN 5.6
Kidney BFTC909 5.5
Kidney CAKI1 5.9
Kidney CAKI2 5.8
Kidney CAL54 6.3
Kidney KMRC1 5
Kidney KMRC20 6.3
Kidney KMRC2 5.3
Kidney KMRC3 4.7
Kidney OSRC2 5.2
Kidney RCC10RGB 5
Kidney SNU1272 5.7
Kidney SNU349 5
Kidney TUHR10TKB 5.9
Kidney TUHR14TKB 5.5
Kidney TUHR4TKB 5.3
Kidney VMRCRCW 6.4
Kidney VMRCRCZ 6.5
Large intestine C2BBE1 5.2
Large intestine CCK81 6.3
Large intestine CL11 6.2
Large intestine CL14 5.9
Large intestine CL34 6.7
Large intestine CL40 6
Large intestine COLO205 8.8
Large intestine COLO320 5.8
Large intestine COLO678 5.8
Large intestine CW2 6.4
Large intestine DLD1 5.6
Large intestine GP2D 6.5
Large intestine HCC56 5.7
Large intestine HCT116 6.1
Large intestine HCT15 5.8
Large intestine HS675T 6.5
Large intestine HS698T 5.8
Large intestine HT115 6
Large intestine HT29 5.9
Large intestine HT55 7.8
Large intestine KM12 5.7
Large intestine LOVO 5.7
Large intestine LS1034 6.9
Large intestine LS123 5.7
Large intestine LS180 6.3
Large intestine LS411N 6.2
Large intestine LS513 6.4
Large intestine MDST8 6
Large intestine NCIH508 5.7
Large intestine NCIH716 6.3
Large intestine NCIH747 5.9
Large intestine OUMS23 5.5
Large intestine RCM1 7.1
Large intestine RKO 4.7
Large intestine SKCO1 7.6
Large intestine SNU1040 6.7
Large intestine SNU1197 6.7
Large intestine SNU175 6.9
Large intestine SNU283 6.4
Large intestine SNU407 6.5
Large intestine SNU503 7.6
Large intestine SNU61 6.2
Large intestine SNU81 6.5
Large intestine SNUC1 6.5
Large intestine SNUC2A 5.9
Large intestine SNUC4 5.9
Large intestine SNUC5 6.3
Large intestine SW1116 6
Large intestine SW1417 7.4
Large intestine SW1463 5.5
Large intestine SW403 6.3
Large intestine SW480 6.8
Large intestine SW48 8.1
Large intestine SW620 9
Large intestine SW837 6.3
Large intestine SW948 6.4
Large intestine T84 5.9
Liver ALEXANDERCELLS 5.4
Liver C3A 6.2
Liver HEP3B217 5.6
Liver HEPG2 6.8
Liver HLE 4.6
Liver HLF 4.5
Liver HUH1 6.1
Liver HUH6 6
Liver HUH7 5.5
Liver JHH1 5
Liver JHH2 6
Liver JHH4 5.3
Liver JHH5 5.7
Liver JHH6 6.9
Liver JHH7 6
Liver LI7 6.2
Liver PLCPRF5 5.1
Liver SKHEP1 5.8
Liver SNU182 5.9
Liver SNU387 6.9
Liver SNU398 5.3
Liver SNU423 5.5
Liver SNU449 6.1
Liver SNU475 5.6
Liver SNU761 5.8
Liver SNU878 5.6
Liver SNU886 5.7
Lung A549 5.8
Lung ABC1 5.5
Lung BEN 7.7
Lung CAL12T 4.9
Lung CALU1 5.3
Lung CALU3 5.9
Lung CALU6 7
Lung CHAGOK1 9.2
Lung COLO668 6.6
Lung COLO699 7
Lung CORL105 5.7
Lung CORL23 4.8
Lung CORL24 7.9
Lung CORL279 5.3
Lung CORL311 7.8
Lung CORL47 5.7
Lung CORL51 7.2
Lung CORL88 7
Lung CORL95 6.7
Lung CPCN 6.4
Lung DMS114 6.3
Lung DMS153 6.6
Lung DMS273 6.7
Lung DMS454 6.6
Lung DMS53 6.3
Lung DMS79 6.2
Lung DV90 5.7
Lung EBC1 5.5
Lung EPLC272H 5.2
Lung HARA 5.4
Lung HCC1171 6
Lung HCC1195 4.9
Lung HCC15 7.5
Lung HCC2279 6.5
Lung HCC2935 6
Lung HCC33 6.5
Lung HCC366 5.4
Lung HCC4006 5.8
Lung HCC44 5.9
Lung HCC78 5.7
Lung HCC827 5.5
Lung HCC95 5.3
Lung HLC1 6.7
Lung HLFA 5.7
Lung HS229T 5.1
Lung HS618T 5.5
Lung IALM 5.5
Lung KNS62 5.1
Lung LC1F 6.1
Lung LC1SQSF 6.8
Lung LCLC103H 4.7
Lung LCLC97TM1 6
Lung LK2 8.2
Lung LOUNH91 5.6
Lung LU65 6.3
Lung LU99 5.3
Lung LUDLU1 7.3
Lung LXF289 8.9
Lung MORCPR 7.4
Lung NCIH1048 6.1
Lung NCIH1092 7.1
Lung NCIH1105 7.8
Lung NCIH1155 6.5
Lung NCIH1184 5.3
Lung NCIH1299 5.4
Lung NCIH1339 6.9
Lung NCIH1341 6.2
Lung NCIH1355 6.3
Lung NCIH1373 6.4
Lung NCIH1385 8
Lung NCIH1395 5.3
Lung NCIH1435 9.2
Lung NCIH1436 7.9
Lung NCIH1437 7
Lung NCIH146 6.3
Lung NCIH1563 6.8
Lung NCIH1568 6.3
Lung NCIH1573 7
Lung NCIH1581 5.7
Lung NCIH1618 5.2
Lung NCIH1623 6.9
Lung NCIH1648 5.3
Lung NCIH1650 5.3
Lung NCIH1651 6
Lung NCIH1666 5.7
Lung NCIH1693 4.9
Lung NCIH1694 6.3
Lung NCIH1703 6.2
Lung NCIH1734 5.3
Lung NCIH1755 7.8
Lung NCIH1781 5.3
Lung NCIH1792 6.8
Lung NCIH1793 5.1
Lung NCIH1836 5.9
Lung NCIH1838 5.8
Lung NCIH1869 5.1
Lung NCIH1876 6.9
Lung NCIH1915 5.7
Lung NCIH1930 5.8
Lung NCIH1944 7.7
Lung NCIH1963 6.7
Lung NCIH196 4.8
Lung NCIH1975 5.8
Lung NCIH2009 5.8
Lung NCIH2023 6.6
Lung NCIH2029 6.2
Lung NCIH2030 6.4
Lung NCIH2066 6.2
Lung NCIH2081 6.7
Lung NCIH2085 5.2
Lung NCIH2087 6.1
Lung NCIH209 6.5
Lung NCIH2106 6.7
Lung NCIH2110 7.2
Lung NCIH211 6.3
Lung NCIH2122 7.2
Lung NCIH2126 6.3
Lung NCIH2141 7.6
Lung NCIH2170 6
Lung NCIH2171 5.6
Lung NCIH2172 6.8
Lung NCIH2196 6.4
Lung NCIH2227 7.2
Lung NCIH2228 6.3
Lung NCIH226 5.8
Lung NCIH2286 6.8
Lung NCIH2291 5.6
Lung NCIH2342 5.6
Lung NCIH2347 5.1
Lung NCIH23 5.9
Lung NCIH2405 6
Lung NCIH2444 5.3
Lung NCIH292 5.3
Lung NCIH322 5
Lung NCIH3255 5.1
Lung NCIH358 6
Lung NCIH441 5.6
Lung NCIH446 5.4
Lung NCIH460 7.4
Lung NCIH510 6.3
Lung NCIH520 8.4
Lung NCIH522 5.9
Lung NCIH524 5.8
Lung NCIH526 6.7
Lung NCIH596 6.2
Lung NCIH647 7.5
Lung NCIH650 6.2
Lung NCIH661 5.7
Lung NCIH69 5.5
Lung NCIH727 6.6
Lung NCIH810 6
Lung NCIH82 5.4
Lung NCIH838 5.6
Lung NCIH841 6.3
Lung NCIH854 7.1
Lung NCIH889 5.3
Lung PC14 6.8
Lung RERFLCAD1 5.7
Lung RERFLCAD2 5
Lung RERFLCAI 5.8
Lung RERFLCKJ 7.4
Lung RERFLCMS 6.3
Lung RERFLCSQ1 5.7
Lung SBC5 5.5
Lung SCLC21H 5.8
Lung SHP77 6.5
Lung SKLU1 5.7
Lung SKMES1 5.9
Lung SQ1 5.4
Lung SW1271 6.3
Lung SW1573 7.1
Lung SW900 5.4
Lung VMRCLCD 6.1
Lung VMRCLCP 5.8
Oesophagus COLO680N 5.4
Oesophagus ECGI10 5.9
Oesophagus KYSE140 6.2
Oesophagus KYSE150 5.3
Oesophagus KYSE180 5.4
Oesophagus KYSE270 5.5
Oesophagus KYSE30 5.2
Oesophagus KYSE410 5.7
Oesophagus KYSE450 6.2
Oesophagus KYSE510 5.6
Oesophagus KYSE520 6.3
Oesophagus KYSE70 6.6
Oesophagus OE19 6
Oesophagus OE33 6.1
Oesophagus TE10 5.4
Oesophagus TE11 5.2
Oesophagus TE14 6.6
Oesophagus TE15 5
Oesophagus TE1 5.3
Oesophagus TE4 7.5
Oesophagus TE5 5.4
Oesophagus TE6 5.9
Oesophagus TE8 6
Oesophagus TE9 5.7
Oesophagus TT 6.7
Ovary 59M 5.8
Ovary A2780 5.8
Ovary CAOV3 5.5
Ovary CAOV4 5.9
Ovary COLO704 5.5
Ovary COV318 6.2
Ovary COV362 5.8
Ovary COV434 6.3
Ovary COV504 5.8
Ovary COV644 6.6
Ovary EFO21 5
Ovary EFO27 5.6
Ovary ES2 5.4
Ovary FUOV1 5.6
Ovary HEYA8 4.9
Ovary HS571T 5.4
Ovary IGROV1 5.2
Ovary JHOC5 4.8
Ovary JHOM1 6.3
Ovary JHOM2B 6.2
Ovary JHOS2 5
Ovary JHOS4 5.1
Ovary KURAMOCHI 5.6
Ovary MCAS 4.9
Ovary NIHOVCAR3 5.4
Ovary OAW28 6.5
Ovary OAW42 6.4
Ovary OC314 5.6
Ovary OC316 5.2
Ovary ONCODG1 5.8
Ovary OV56 5.6
Ovary OV7 6.4
Ovary OV90 6.6
Ovary OVCAR4 5.1
Ovary OVCAR8 5.2
Ovary OVISE 5.7
Ovary OVK18 6.8
Ovary OVKATE 5.1
Ovary OVMANA 6.2
Ovary OVSAHO 5.2
Ovary OVTOKO 5.4
Ovary RMGI 4.8
Ovary RMUGS 6.1
Ovary SKOV3 6.4
Ovary SNU119 5.6
Ovary SNU840 5.4
Ovary SNU8 5.4
Ovary TOV112D 6.1
Ovary TOV21G 6
Ovary TYKNU 5.4
Pancreas ASPC1 6.1
Pancreas BXPC3 5
Pancreas CAPAN1 6.9
Pancreas CAPAN2 6.1
Pancreas CFPAC1 6.1
Pancreas DANG 5.7
Pancreas HPAC 5.1
Pancreas HPAFII 6
Pancreas HS766T 5.5
Pancreas HUPT3 5.8
Pancreas HUPT4 5.2
Pancreas KCIMOH1 5
Pancreas KLM1 5.2
Pancreas KP2 6.2
Pancreas KP3 5.4
Pancreas KP4 6.3
Pancreas L33 6.1
Pancreas MIAPACA2 6.4
Pancreas PANC0203 5.8
Pancreas PANC0213 5.5
Pancreas PANC0327 5.1
Pancreas PANC0403 6.6
Pancreas PANC0504 5.4
Pancreas PANC0813 5.5
Pancreas PANC1005 5.5
Pancreas PANC1 5.9
Pancreas PATU8902 5.4
Pancreas PATU8988S 6.3
Pancreas PATU8988T 5.5
Pancreas PK1 5
Pancreas PK45H 5.9
Pancreas PK59 5.9
Pancreas PL45 5.6
Pancreas PSN1 6.2
Pancreas QGP1 6.4
Pancreas SNU213 5.7
Pancreas SNU324 6.1
Pancreas SNU410 6
Pancreas SU8686 6.4
Pancreas SUIT2 7.1
Pancreas SW1990 5.5
Pancreas T3M4 5.1
Pancreas TCCPAN2 6.6
Pancreas YAPC 7
Pleura ACCMESO1 5.3
Pleura DM3 5.5
Pleura ISTMES1 6
Pleura ISTMES2 6.3
Pleura JL1 6.9
Pleura MPP89 5.2
Pleura MSTO211H 5.9
Pleura NCIH2052 5.5
Pleura NCIH2452 5.7
Pleura NCIH28 7
Prostate 22RV1 5
Prostate DU145 5.6
Prostate LNCAPCLONEFGC 5.4
Prostate MDAPCA2B 6
Prostate NCIH660 5.4
Prostate PC3 5.6
Prostate VCAP 5.9
Salivary gland A253 6.5
Salivary gland YD15 4.7
Skin A101D 5.9
Skin A2058 7.3
Skin A375 5.6
Skin C32 5.6
Skin CHL1 8
Skin CJM 4.7
Skin COLO679 7.3
Skin COLO741 5.9
Skin COLO783 7.7
Skin COLO792 7.1
Skin COLO800 7
Skin COLO818 6.8
Skin COLO829 5.6
Skin COLO849 6.3
Skin G361 6.4
Skin GRM 7
Skin HMCB 7.5
Skin HS294T 6
Skin HS600T 5.8
Skin HS688AT 5.4
Skin HS695T 5.7
Skin HS839T 5.6
Skin HS852T 6.1
Skin HS895T 5.5
Skin HS934T 5.8
Skin HS936T 7
Skin HS939T 6.6
Skin HS940T 5.5
Skin HS944T 6
Skin HT144 6.4
Skin IGR1 7.5
Skin IGR37 6.9
Skin IGR39 5.3
Skin IPC298 6.6
Skin K029AX 7.2
Skin LOXIMVI 5.1
Skin MALME3M 6.8
Skin MDAMB435S 6.8
Skin MELHO 6.2
Skin MELJUSO 6.6
Skin MEWO 7.7
Skin RPMI7951 6.1
Skin RVH421 6.2
Skin SH4 7.2
Skin SKMEL1 7.3
Skin SKMEL24 6.7
Skin SKMEL28 7.7
Skin SKMEL2 5.9
Skin SKMEL30 7.5
Skin SKMEL31 5.2
Skin SKMEL3 6
Skin SKMEL5 6.5
Skin UACC257 7.2
Skin UACC62 6.5
Skin WM115 6
Skin WM1799 6.9
Skin WM2664 5.7
Skin WM793 6.6
Skin WM88 7.2
Skin WM983B 7.4
Small intestine HUTU80 6.2
Soft tissue A204 5.8
Soft tissue G401 6
Soft tissue G402 6.4
Soft tissue GCT 4.7
Soft tissue HS729 5.1
Soft tissue HT1080 5.5
Soft tissue KYM1 6.1
Soft tissue MESSA 6.4
Soft tissue RD 7.2
Soft tissue RH30 7.6
Soft tissue RH41 6.2
Soft tissue RKN 6.1
Soft tissue S117 5.9
Soft tissue SJRH30 6.1
Soft tissue SKLMS1 5.4
Soft tissue SKUT1 5.6
Soft tissue TE125T 5.8
Soft tissue TE159T 5.8
Soft tissue TE441T 7.7
Soft tissue TE617T 5.8
Stomach 2313287 7
Stomach AGS 5.3
Stomach AZ521 6.7
Stomach ECC10 7.6
Stomach ECC12 6.9
Stomach FU97 5.8
Stomach GCIY 5.3
Stomach GSS 8.3
Stomach GSU 6.6
Stomach HGC27 6.2
Stomach HS746T 4.9
Stomach HUG1N 6.3
Stomach IM95 6.1
Stomach KATOIII 5.6
Stomach KE39 7.6
Stomach LMSU 5
Stomach MKN1 6.2
Stomach MKN45 7.6
Stomach MKN74 5.4
Stomach MKN7 5.2
Stomach NCCSTCK140 4.6
Stomach NCIN87 6.7
Stomach NUGC2 5.4
Stomach NUGC3 5.4
Stomach NUGC4 6.3
Stomach OCUM1 7.1
Stomach RERFGC1B 5.4
Stomach SH10TC 6.2
Stomach SNU16 6.5
Stomach SNU1 4.8
Stomach SNU216 5.3
Stomach SNU520 6.3
Stomach SNU5 6.3
Stomach SNU601 5.5
Stomach SNU620 6.2
Stomach SNU668 7.6
Stomach SNU719 6.4
Stomach TGBC11TKB 6.5
Thyroid 8305C 4.9
Thyroid 8505C 5.1
Thyroid BCPAP 5.4
Thyroid BHT101 6.7
Thyroid CAL62 5.7
Thyroid CGTHW1 6.7
Thyroid FTC133 5.7
Thyroid FTC238 6.1
Thyroid ML1 6.9
Thyroid SW579 5.8
Thyroid TT2609C02 6
Thyroid TT 6.9
Upper aerodigestive tract BHY 4.8
Upper aerodigestive tract BICR16 5.3
Upper aerodigestive tract BICR18 5.2
Upper aerodigestive tract BICR22 5.7
Upper aerodigestive tract BICR31 5.6
Upper aerodigestive tract BICR56 4.8
Upper aerodigestive tract BICR6 4.8
Upper aerodigestive tract CAL27 5.2
Upper aerodigestive tract CAL33 5.4
Upper aerodigestive tract DETROIT562 4.9
Upper aerodigestive tract FADU 5.9
Upper aerodigestive tract HS840T 5.7
Upper aerodigestive tract HSC2 4.7
Upper aerodigestive tract HSC3 5
Upper aerodigestive tract HSC4 5.2
Upper aerodigestive tract PECAPJ15 6
Upper aerodigestive tract PECAPJ34CLONEC12 6.2
Upper aerodigestive tract PECAPJ41CLONED2 5.6
Upper aerodigestive tract PECAPJ49 5.6
Upper aerodigestive tract SCC15 5.4
Upper aerodigestive tract SCC25 5.4
Upper aerodigestive tract SCC4 5.3
Upper aerodigestive tract SCC9 5.7
Upper aerodigestive tract SNU1076 5.2
Upper aerodigestive tract SNU1214 5.2
Upper aerodigestive tract SNU46 5.5
Upper aerodigestive tract SNU899 5.4
Upper aerodigestive tract YD10B 5
Upper aerodigestive tract YD38 5.7
Upper aerodigestive tract YD8 5.9
Urinary tract 5637 5.8
Urinary tract 639V 6
Urinary tract 647V 5.6
Urinary tract BC3C 6.2
Urinary tract BFTC905 6.5
Urinary tract CAL29 5.6
Urinary tract HS172T 5.5
Urinary tract HT1197 5.2
Urinary tract HT1376 5
Urinary tract J82 5
Urinary tract JMSU1 6.5
Urinary tract KMBC2 6
Urinary tract KU1919 5.2
Urinary tract RT11284 6.6
Urinary tract RT112 5.3
Urinary tract RT4 5.7
Urinary tract SCABER 5.1
Urinary tract SW1710 6.1
Urinary tract SW780 5.8
Urinary tract T24 5.3
Urinary tract TCCSUP 5.6
Urinary tract UMUC1 5.3
Urinary tract UMUC3 5.8
Urinary tract VMCUB1 4.7
> The Human Protein Atlas (HPA)
 


Tissue Expression Level (TPM)
Adipose tissue 6.3
Adrenal gland 8.7
Appendix 10
Bone marrow 12.6
Breast 5.5
Cerebral cortex 19.4
Cervix, uterine 11.2
Colon 6.7
Duodenum 2.7
Endometrium 13.7
Epididymis 4.1
Esophagus 9.6
Fallopian tube 14
Gallbladder 12.2
Heart muscle 3.5
Kidney 3.4
Liver 0.8
Lung 5.8
Lymph node 5.6
Ovary 9.9
Pancreas 0.8
Parathyroid gland 7.4
Placenta 3.7
Prostate 7.3
Rectum 5.2
Salivary gland 1.4
Seminal vesicle 9.4
Skeletal muscle 9.9
Skin 8.4
Small intestine 5.7
Smooth muscle 11.5
Spleen 7.5
Stomach 3.2
Testis 12.1
Thyroid gland 7.9
Tonsil 3.2
Urinary bladder 6.5
> Text Mining based Expression
 
PMID Expression Cancer Evidence
16865262underexpressionColon Carcinoma; Lung CarcinomaIn colon carcinomas, the RPS6KA6, HDAC4, KIAA0828 and Tip60 genes were downregulated in tumor tissue as compared with normal tissue (P < 0.001 for all genes). In lung carcinomas, HDAC4, KIAA0820 and Tip60 were downregulated (P < 0.01, P < 0.001 and P < 0.001 respectively).
20636436overexpressionT Acute Lymphoblastic LeukemiaHDAC1 and HDAC4 showed high expression in T-ALL and HDAC5 was highly expressed in B-lineage ALL.
22944197underexpressionUrothelial CarcinomaProminent changes in UCCs were HDAC2 and/or HDAC8 up-regulation in 11 of 18 cell lines and decreased expression of HDAC4, HDAC5, and/or HDAC7 mRNA in 15 of 18 cell lines.
27295551overexpressionEsophageal Squamous Cell CarcinomaWe found that HDAC4 mRNA and protein are overexpressed in esophageal squamous cell carcinoma (ESCC) tissues and cell lines.
26433312overexpressionPlasma Cell MyelomaGene expression profiling indicated that multiple targets of the decreased miRNAs found increased expression in MM plasma cells, including ATF2, HRAS, HDAC4, TGFB1, TGFBR1, and mitogen-activated protein kinases.
24896240overexpressionGastric CarcinomaHDAC4 was up-regulated in gastric cancer tissues and several gastric cancer cell lines.
23948281overexpressionT Acute Lymphoblastic LeukemiaParticularly, high HDAC4 expression was associated with high initial leukocyte count, T cell ALL and prednisone poor-response.
23873102overexpressionPapillary Carcinoma; Malignant Thyroid LesionEnhanced HDAC-2, HDAC-4, and HDAC-6 expression was significantly more frequently observed in cases with papillary carcinoma compared to hyperplastic nodules (p=0.0065, p=0.0394, and p=0.0061, respectively). In malignant thyroid lesions, HDAC-1, HDAC-4, and HDAC-6 expression was significantly associated with tumor size (p=0.0169, p=0.0056, and p=0.0234, respectively); HDAC-2 expression with lymphatic and vascular invasion (p=0.0299 and p=0.0391, respectively); and HDAC-4 expression with capsular invasion (p=0.0464).
22270866overexpressionColorectal AdenocarcinomaThe immunohistochemical staining of HDACs, including HDAC1, HDAC2, HDAC3, and HDAC4, was significantly increased in colorectal adenocarcinoma specimens compared to healthy control tissues.
21507255overexpressionBladder CarcinomaThe results of our immunohistochemistry (IHC) staining studies further revealed a strong correlation between the over-expression of HDAC4 and increased bladder cancer occurrence (p < 0.001) as well as a marginal significance of increasing incidence of HDAC4 positivity seen with an increase in severity of bladder cancer (p = 0.08).
20842113overexpressionHepatocellular CarcinomaFurthermore, HDAC4 was upregulated in miR-22-downregulated HCC tissues, suggesting that downregulation of miR-22 might participate in HCC carcinogenesis and progression through potentiation of HDAC4 expression.
20041488overexpressionChordomaThese targets included Met and HDAC4-two genes that were observed to be overexpressed in chordoma.
27793800UnderexpressionChronic Obstructive Pulmonary DiseaseOur qPCR validation data revealed a significant downregulation of Dnmt1, Dnmt3a, Dnmt3b, Hdac2, Hdac4, Hat1, Prmt1, and Aurkb.
28646552OverexpressionHepatocellular CarcinomaBecause histone deacetylase 4 (HDAC4) is highly expressed in liver cancer and known to regulate oncogenesis through chromatin structure remodeling and controlling protein access to DNA, we postulated that HDAC4 inhibition might enhance radiation's effect on HCC cells.
28419090OverexpressionLeiomyosarcomaClass IIa HDACs are overexpressed in 22% of LMS, where high levels of MEF2, HDAC4 and HDAC9 inversely correlate with overall survival.
Summary
SymbolHDAC4
Namehistone deacetylase 4
Aliases KIAA0288; HDAC-A; HDACA; HD4; HA6116; HDAC-4; BDMR; brachydactyly-mental retardation syndrome; AHO3; histone ......
Location2q37.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content > Somatic copy number alteration in primary tomur tissue
> The Cancer Genome Atlas (TCGA)
 


  Correlation between expression and SCNA as well as percentage of patients in different status.
Cancer Full Name # Sample R P % Loss % Neutral % Gain Status
BLCABladder urothelial carcinoma4040.4391.65e-2048.847.34Loss
BRCABreast invasive carcinoma10750.3264.16e-2828.764.86.4Neutral
CESCCervical and endocervical cancers2920.4461.15e-1541.154.84.1Loss
COADColon adenocarcinoma4490.2583.07e-084.576.818.7Neutral
ESCAEsophageal carcinoma1830.2790.00012926.254.119.7Neutral
GBMGlioblastoma multiforme1470.0910.2747.587.84.8Neutral
HNSCHead and Neck squamous cell carcinoma5140.3951.14e-2029.462.68Neutral
KIRCKidney renal clear cell carcinoma5250.4063.05e-22977.113.9Neutral
KIRPKidney renal papillary cell carcinoma2880.3889.37e-124.280.215.6Neutral
LAMLAcute Myeloid Leukemia1660.0440.5720.699.40Neutral
LGGBrain Lower Grade Glioma5130.2941.17e-1113.584.61.9Neutral
LIHCLiver hepatocellular carcinoma3640.3797.43e-1416.871.212.1Neutral
LUADLung adenocarcinoma5120.4692.52e-2912.362.125.6Neutral
LUSCLung squamous cell carcinoma4980.1670.00017530.35415.7Neutral
OVOvarian serous cystadenocarcinoma3000.5731.41e-273341.325.7Neutral
PAADPancreatic adenocarcinoma1770.1040.175.682.511.9Neutral
PCPGPheochromocytoma and Paraganglioma1620.3671.59e-068.690.11.2Neutral
PRADProstate adenocarcinoma4910.0880.05028.1901.8Neutral
READRectum adenocarcinoma1640.1880.01566.767.126.2Neutral
SARCSarcoma2550.441.63e-1341.648.210.2Loss
SKCMSkin Cutaneous Melanoma3670.4065.11e-1625.358.316.3Neutral
STADStomach adenocarcinoma4130.2121.34e-0516.568.315.3Neutral
TGCTTesticular Germ Cell Tumors1500.3889.39e-0711.364.724Neutral
THCAThyroid carcinoma497-0.0320.4742.497.40.2Neutral
THYMThymoma1190.0860.3522.597.50Neutral
UCECUterine Corpus Endometrial Carcinoma5370.4353.1e-268.877.114.2Neutral
Summary
SymbolHDAC4
Namehistone deacetylase 4
Aliases KIAA0288; HDAC-A; HDACA; HD4; HA6116; HDAC-4; BDMR; brachydactyly-mental retardation syndrome; AHO3; histone ......
Location2q37.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content > Methylation level in the promoter region of CR
> Methylation level in the promoter region of CR
 


  Correlation between expression and methylation as well as differential methylation analysis.
Cancer Full Name R P # N # T Delta beta (T vs N) P value (T vs N) Status
BLCABladder urothelial carcinoma-0.3221.37e-11174080.0530.0142NS/NA
BRCABreast invasive carcinoma-0.3560837850.1464.72e-52NS/NA
CESCCervical and endocervical cancers-0.3722.06e-113306NANANS/NA
COADColon adenocarcinoma-0.2382.09e-05192970.0110.499NS/NA
ESCAEsophageal carcinoma-0.2690.0001549185NANANS/NA
GBMGlioblastoma multiforme-0.3570.00367164NANANS/NA
HNSCHead and Neck squamous cell carcinoma-0.2551.97e-09205220.0035.49e-12NS/NA
KIRCKidney renal clear cell carcinoma-0.2137.41e-05243190.0260.779NS/NA
KIRPKidney renal papillary cell carcinoma-0.2791.13e-06232750.0050.00179NS/NA
LAMLAcute Myeloid Leukemia-0.3331.03e-050170NANANS/NA
LGGBrain Lower Grade Glioma-0.3491.3e-160530NANANS/NA
LIHCLiver hepatocellular carcinoma-0.1840.00016541373-0.0051.13e-14NS/NA
LUADLung adenocarcinoma-0.2152.2e-0621456-0.0070.0225NS/NA
LUSCLung squamous cell carcinoma-0.2221.42e-058370NANANS/NA
OVOvarian serous cystadenocarcinoma-0.7670.021409NANANS/NA
PAADPancreatic adenocarcinoma-0.3082.37e-054179NANANS/NA
PCPGPheochromocytoma and Paraganglioma-0.49203184NANANS/NA
PRADProstate adenocarcinoma-0.43035498-0.0310.105NS/NA
READRectum adenocarcinoma-0.2320.0197299NANANS/NA
SARCSarcoma-0.4143.53e-120263NANANS/NA
SKCMSkin Cutaneous Melanoma-0.2542.56e-081471NANANS/NA
STADStomach adenocarcinoma-0.2412.76e-060372NANANS/NA
TGCTTesticular Germ Cell Tumors-0.318.93e-050156NANANS/NA
THCAThyroid carcinoma-0.3023.83e-13505090.0749.44e-20NS/NA
THYMThymoma-0.270.002762120NANANS/NA
UCECUterine Corpus Endometrial Carcinoma-0.3192.38e-12344310.0250.00233NS/NA
Summary
SymbolHDAC4
Namehistone deacetylase 4
Aliases KIAA0288; HDAC-A; HDACA; HD4; HA6116; HDAC-4; BDMR; brachydactyly-mental retardation syndrome; AHO3; histone ......
Location2q37.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content > Primary tumor tissue from TCGA
> Normal tumor tissue from HPA
>The Cancer Genome Atlas (TCGA)
 
There is no record.
> The Human Protein Atlas (HPA)
 


Tissue Level Level Name
Appendix 2 Medium
Bone marrow 3 High
Breast 3 High
Bronchus 2 Medium
Caudate 2 Medium
Cerebellum 2 Medium
Cerebral cortex 3 High
Cervix, uterine 3 High
Colon 3 High
Duodenum 3 High
Endometrium 3 High
Epididymis 3 High
Esophagus 2 Medium
Fallopian tube 2 Medium
Gallbladder 3 High
Heart muscle 1 Low
Hippocampus 2 Medium
Kidney 2 Medium
Liver 2 Medium
Lung 3 High
Lymph node 3 High
Nasopharynx 2 Medium
Oral mucosa 2 Medium
Ovary 2 Medium
Pancreas 3 High
Parathyroid gland 2 Medium
Placenta 3 High
Prostate 2 Medium
Rectum 3 High
Salivary gland 3 High
Seminal vesicle 2 Medium
Skeletal muscle 2 Medium
Skin 2 Medium
Small intestine 3 High
Smooth muscle 1 Low
Soft tissue 2 Medium
Spleen 2 Medium
Stomach 2 Medium
Testis 3 High
Thyroid gland 3 High
Tonsil 3 High
Urinary bladder 2 Medium
Vagina 2 Medium
Summary
SymbolHDAC4
Namehistone deacetylase 4
Aliases KIAA0288; HDAC-A; HDACA; HD4; HA6116; HDAC-4; BDMR; brachydactyly-mental retardation syndrome; AHO3; histone ......
Location2q37.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content > Association between expresson and subtype
> Overall survival analysis based on expression
> Association between expresson and stage
> Association between expresson and grade
> Subtype
 


  Association between expresson and subtype.
Cancer Full Name # Patients P Value (Kruskal-Wallis) Association Source
BLCABladder urothelial carcinoma1280.00412Significant24476821
BRCABreast invasive carcinoma5218.64e-06Significant23000897
COADColon adenocarcinoma1490.615NS22810696
GBMGlioblastoma multiforme1570.000288Significant26824661
HNSCHead and Neck squamous cell carcinoma2790.000415Significant25631445
KIRPKidney renal papillary cell carcinoma1610.0795NS26536169
LGGBrain Lower Grade Glioma5135.01e-53Significant26824661
LUADLung adenocarcinoma2300.000119Significant25079552
LUSCLung squamous cell carcinoma1783.8e-07Significant22960745
OVOvarian serous cystadenocarcinoma2879.4e-05Significant21720365
PRADProstate adenocarcinoma3331.04e-17Significant26544944
READRectum adenocarcinoma670.402NS22810696
SKCMSkin Cutaneous Melanoma3150.000495Significant26091043
STADStomach adenocarcinoma2773.43e-07Significant25079317
THCAThyroid carcinoma3914.74e-11Significant25417114
UCECUterine Corpus Endometrial Carcinoma2320.0515NS23636398
> Overall survival
 

  Overall survival analysis based on expression.
Cancer Full Name # Patients Hazard Ratio P Value (Log Rank Test) Association
BLCABladder urothelial carcinoma405 1.0790.713NS
BRCABreast invasive carcinoma1079 1.0150.949NS
CESCCervical and endocervical cancers291 1.7330.107NS
COADColon adenocarcinoma439 0.8640.621NS
ESCAEsophageal carcinoma184 0.8720.682NS
GBMGlioblastoma multiforme158 0.4420.00203Longer
HNSCHead and Neck squamous cell carcinoma518 0.5650.00287Longer
KIRCKidney renal clear cell carcinoma531 0.9680.887NS
KIRPKidney renal papillary cell carcinoma287 1.2560.549NS
LAMLAcute Myeloid Leukemia149 0.7690.359NS
LGGBrain Lower Grade Glioma511 0.2541.67e-08Longer
LIHCLiver hepatocellular carcinoma365 1.4480.111NS
LUADLung adenocarcinoma502 1.1890.397NS
LUSCLung squamous cell carcinoma494 0.9990.996NS
OVOvarian serous cystadenocarcinoma303 1.7190.0122Shorter
PAADPancreatic adenocarcinoma177 0.4190.00199Longer
PCPGPheochromocytoma and Paraganglioma179 1.2470.876NS
PRADProstate adenocarcinoma497 0.6640.591NS
READRectum adenocarcinoma159 1.340.541NS
SARCSarcoma259 0.6190.0963NS
SKCMSkin Cutaneous Melanoma459 1.6940.00476Shorter
STADStomach adenocarcinoma388 1.0560.812NS
TGCTTesticular Germ Cell Tumors134 00.0781NS
THCAThyroid carcinoma500 2.1640.222NS
THYMThymoma119 0.3110.172NS
UCECUterine Corpus Endometrial Carcinoma543 1.8660.0383Shorter
> Stage
 

  Association between expresson and stage.
Cancer Full Name # Patients R Value (Spearman) P Value (Spearman) Association
BLCABladder urothelial carcinoma406 0.0060.898NS
BRCABreast invasive carcinoma1071 -0.1020.000876Lower
CESCCervical and endocervical cancers167 0.1570.0428Higher
COADColon adenocarcinoma445 0.0040.937NS
ESCAEsophageal carcinoma162 -0.150.056NS
HNSCHead and Neck squamous cell carcinoma448 -0.0880.064NS
KIRCKidney renal clear cell carcinoma531 -0.1470.000694Lower
KIRPKidney renal papillary cell carcinoma260 -0.0460.459NS
LIHCLiver hepatocellular carcinoma347 0.1210.0237Higher
LUADLung adenocarcinoma507 0.0680.125NS
LUSCLung squamous cell carcinoma497 -0.0620.165NS
OVOvarian serous cystadenocarcinoma302 -0.0350.544NS
PAADPancreatic adenocarcinoma176 -0.1650.0291Lower
READRectum adenocarcinoma156 -0.0310.702NS
SKCMSkin Cutaneous Melanoma410 -0.0330.507NS
STADStomach adenocarcinoma392 -0.030.551NS
TGCTTesticular Germ Cell Tumors81 -0.0510.648NS
THCAThyroid carcinoma499 -0.0810.069NS
UCECUterine Corpus Endometrial Carcinoma501 0.1040.02Higher
> Grade
 

  Association between expresson and grade.
Cancer Full Name # Patients R Value (Spearman) P Value (Spearman) Association
CESCCervical and endocervical cancers272 -0.0830.172NS
HNSCHead and Neck squamous cell carcinoma498 -0.1260.00489Lower
KIRCKidney renal clear cell carcinoma525 -0.0660.132NS
LGGBrain Lower Grade Glioma514 -0.258.77e-09Lower
LIHCLiver hepatocellular carcinoma366 0.0370.483NS
OVOvarian serous cystadenocarcinoma296 -0.1110.0567NS
PAADPancreatic adenocarcinoma176 -0.2020.00718Lower
STADStomach adenocarcinoma406 0.1220.0136Higher
UCECUterine Corpus Endometrial Carcinoma534 0.0650.131NS
Summary
SymbolHDAC4
Namehistone deacetylase 4
Aliases KIAA0288; HDAC-A; HDACA; HD4; HA6116; HDAC-4; BDMR; brachydactyly-mental retardation syndrome; AHO3; histone ......
Location2q37.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content > Targets inferred by reverse engineering method
> Targets identified by ChIP-seq data
> Targets inferred by reverse engineering method
 
> Targets identified by ChIP-seq data
 
Summary
SymbolHDAC4
Namehistone deacetylase 4
Aliases KIAA0288; HDAC-A; HDACA; HD4; HA6116; HDAC-4; BDMR; brachydactyly-mental retardation syndrome; AHO3; histone ......
Location2q37.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content > Drugs from DrugBank database
> Drugs from DrugBank database
 
DrugBank ID Name Type All Targets
DB06176RomidepsinSmall Molecule Drug
DB07879N-hydroxy-5-[(3-phenyl-5,6-dihydroimidazo[1,2-a]pyrazin-7(8H)-yl)carbonyl]thiophene-2-carboxamideSmall Molecule Drug
DB086132,2,2-TRIFLUORO-1-{5-[(3-PHENYL-5,6-DIHYDROIMIDAZO[1,2-A]PYRAZIN-7(8H)-YL)CARBONYL]THIOPHEN-2-YL}ETHANE-1,1-DIOLSmall Molecule Drug
DB05015BelinostatSmall Molecule Drug
DB06603PanobinostatSmall Molecule Drug
DB06176RomidepsinSmall Molecule Drug
DB07879N-hydroxy-5-[(3-phenyl-5,6-dihydroimidazo[1,2-a]pyrazin-7(8H)-yl)carbonyl]thiophene-2-carboxamideSmall Molecule Drug
DB086132,2,2-TRIFLUORO-1-{5-[(3-PHENYL-5,6-DIHYDROIMIDAZO[1,2-A]PYRAZIN-7(8H)-YL)CARBONYL]THIOPHEN-2-YL}ETHANE-1,1-DIOLSmall Molecule Drug
DB05015BelinostatSmall Molecule Drug
DB06603PanobinostatSmall Molecule Drug
Summary
SymbolHDAC4
Namehistone deacetylase 4
Aliases KIAA0288; HDAC-A; HDACA; HD4; HA6116; HDAC-4; BDMR; brachydactyly-mental retardation syndrome; AHO3; histone ......
Location2q37.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content > Protein-Protein Interaction Network
> miRNA Regulatory Relationship
> Interactions from Text Mining
> Protein-Protein Interaction Network
 
> miRNA Regulatory Relationship
 
> Interactions from Text Mining
 
PMID Cancer Hierarchy Gene Relation to CR Evidence
27295551Esophageal Squamous Cell CarcinomadownstreamVIM; CTNNA1positive regulation; negative regulationFurthermore, HDAC4 positively regulates epithelial-mesenchymal transition (EMT) by increasing the expression of Vimentin and decreasing the expression of E-Cadherin/α-Catenin.