CR2Cancer

Summary
Symbol	HDAC6
Name	histone deacetylase 6
Aliases	KIAA0901; JM21; FLJ16239; PPP1R90; protein phosphatase 1, regulatory subunit 90; CPBHM
Location	Xp11.23
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Domain, Function and Classification > Gene Ontology > KEGG and Reactome Pathway

> Domain, Function and Classification

[ TOP ]

Domain

PF00850 Histone deacetylase domain
PF02148 Zn-finger in ubiquitin-hydrolases and other protein

Function

Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes (By similarity). Plays a central role in microtubule-dependent cell motility via deacetylation of tubulin. Involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer. ; FUNCTION: In addition to its protein deacetylase activity, plays a key role in the degradation of misfolded proteins: when misfolded proteins are too abundant to be degraded by the chaperone refolding system and the ubiquitin-proteasome, mediates the transport of misfolded proteins to a cytoplasmic juxtanuclear structure called aggresome. Probably acts as an adapter that recognizes polyubiquitinated misfolded proteins and target them to the aggresome, facilitating their clearance by autophagy.

Classification

Class	Modification	Substrate	Product	PubMed
Histone modification erase	Histone acetylation	H2AKac, H2BKac, H3Kac, H4Kac	H2AK, H2BK, H3K, H4K	10220385

> Gene Ontology [ TOP ]
Biological Process	GO:0000209 protein polyubiquitination GO:0000226 microtubule cytoskeleton organization GO:0000302 response to reactive oxygen species GO:0000422 mitophagy GO:0000423 macromitophagy GO:0001667 ameboidal-type cell migration GO:0006476 protein deacetylation GO:0006515 misfolded or incompletely synthesized protein catabolic process GO:0006914 autophagy GO:0006979 response to oxidative stress GO:0007018 microtubule-based movement GO:0007019 microtubule depolymerization GO:0007026 negative regulation of microtubule depolymerization GO:0007409 axonogenesis GO:0009636 response to toxic substance GO:0009755 hormone-mediated signaling pathway GO:0010035 response to inorganic substance GO:0010310 regulation of hydrogen peroxide metabolic process GO:0010421 hydrogen peroxide-mediated programmed cell death GO:0010469 regulation of receptor activity GO:0010506 regulation of autophagy GO:0010631 epithelial cell migration GO:0010632 regulation of epithelial cell migration GO:0010634 positive regulation of epithelial cell migration GO:0010639 negative regulation of organelle organization GO:0010727 negative regulation of hydrogen peroxide metabolic process GO:0010821 regulation of mitochondrion organization GO:0010869 regulation of receptor biosynthetic process GO:0010870 positive regulation of receptor biosynthetic process GO:0016049 cell growth GO:0016236 macroautophagy GO:0016358 dendrite development GO:0016570 histone modification GO:0016575 histone deacetylation GO:0018205 peptidyl-lysine modification GO:0030335 positive regulation of cell migration GO:0030518 intracellular steroid hormone receptor signaling pathway GO:0030521 androgen receptor signaling pathway GO:0030522 intracellular receptor signaling pathway GO:0031109 microtubule polymerization or depolymerization GO:0031110 regulation of microtubule polymerization or depolymerization GO:0031111 negative regulation of microtubule polymerization or depolymerization GO:0031114 regulation of microtubule depolymerization GO:0031334 positive regulation of protein complex assembly GO:0031647 regulation of protein stability GO:0032418 lysosome localization GO:0032800 receptor biosynthetic process GO:0032886 regulation of microtubule-based process GO:0032984 macromolecular complex disassembly GO:0033143 regulation of intracellular steroid hormone receptor signaling pathway GO:0034599 cellular response to oxidative stress GO:0034614 cellular response to reactive oxygen species GO:0034983 peptidyl-lysine deacetylation GO:0035601 protein deacylation GO:0035966 response to topologically incorrect protein GO:0035967 cellular response to topologically incorrect protein GO:0036473 cell death in response to oxidative stress GO:0036474 cell death in response to hydrogen peroxide GO:0040017 positive regulation of locomotion GO:0040029 regulation of gene expression, epigenetic GO:0042542 response to hydrogen peroxide GO:0042743 hydrogen peroxide metabolic process GO:0043112 receptor metabolic process GO:0043162 ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway GO:0043241 protein complex disassembly GO:0043242 negative regulation of protein complex disassembly GO:0043244 regulation of protein complex disassembly GO:0043254 regulation of protein complex assembly GO:0043401 steroid hormone mediated signaling pathway GO:0043624 cellular protein complex disassembly GO:0044089 positive regulation of cellular component biogenesis GO:0045444 fat cell differentiation GO:0045598 regulation of fat cell differentiation GO:0045861 negative regulation of proteolysis GO:0048545 response to steroid hormone GO:0048588 developmental cell growth GO:0048667 cell morphogenesis involved in neuron differentiation GO:0048668 collateral sprouting GO:0048813 dendrite morphogenesis GO:0051131 chaperone-mediated protein complex assembly GO:0051261 protein depolymerization GO:0051272 positive regulation of cellular component movement GO:0051341 regulation of oxidoreductase activity GO:0051354 negative regulation of oxidoreductase activity GO:0051493 regulation of cytoskeleton organization GO:0051494 negative regulation of cytoskeleton organization GO:0051640 organelle localization GO:0051646 mitochondrion localization GO:0051788 response to misfolded protein GO:0060560 developmental growth involved in morphogenesis GO:0060632 regulation of microtubule-based movement GO:0060765 regulation of androgen receptor signaling pathway GO:0060996 dendritic spine development GO:0060997 dendritic spine morphogenesis GO:0061564 axon development GO:0061726 mitochondrion disassembly GO:0070301 cellular response to hydrogen peroxide GO:0070507 regulation of microtubule cytoskeleton organization GO:0070841 inclusion body assembly GO:0070842 aggresome assembly GO:0070843 misfolded protein transport GO:0070844 polyubiquitinated protein transport GO:0070845 polyubiquitinated misfolded protein transport GO:0070846 Hsp90 deacetylation GO:0070932 histone H3 deacetylation GO:0071218 cellular response to misfolded protein GO:0071383 cellular response to steroid hormone stimulus GO:0071396 cellular response to lipid GO:0071407 cellular response to organic cyclic compound GO:0072593 reactive oxygen species metabolic process GO:0090034 regulation of chaperone-mediated protein complex assembly GO:0090035 positive regulation of chaperone-mediated protein complex assembly GO:0090042 tubulin deacetylation GO:0090130 tissue migration GO:0090132 epithelium migration GO:0097061 dendritic spine organization GO:0097468 programmed cell death in response to reactive oxygen species GO:0098732 macromolecule deacylation GO:0098779 mitophagy in response to mitochondrial depolarization GO:0098780 response to mitochondrial depolarisation GO:1900407 regulation of cellular response to oxidative stress GO:1900409 positive regulation of cellular response to oxidative stress GO:1901031 regulation of response to reactive oxygen species GO:1901033 positive regulation of response to reactive oxygen species GO:1901298 regulation of hydrogen peroxide-mediated programmed cell death GO:1901300 positive regulation of hydrogen peroxide-mediated programmed cell death GO:1901879 regulation of protein depolymerization GO:1901880 negative regulation of protein depolymerization GO:1902882 regulation of response to oxidative stress GO:1902884 positive regulation of response to oxidative stress GO:1903008 organelle disassembly GO:1903146 regulation of mitophagy GO:1903201 regulation of oxidative stress-induced cell death GO:1903205 regulation of hydrogen peroxide-induced cell death GO:1903209 positive regulation of oxidative stress-induced cell death GO:1905206 positive regulation of hydrogen peroxide-induced cell death GO:2000147 positive regulation of cell motility GO:2000377 regulation of reactive oxygen species metabolic process GO:2000378 negative regulation of reactive oxygen species metabolic process
Molecular Function	GO:0001047 core promoter binding GO:0003779 actin binding GO:0004407 histone deacetylase activity GO:0008013 beta-catenin binding GO:0008017 microtubule binding GO:0015631 tubulin binding GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds GO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides GO:0017136 NAD-dependent histone deacetylase activity GO:0019213 deacetylase activity GO:0031072 heat shock protein binding GO:0031078 histone deacetylase activity (H3-K14 specific) GO:0031593 polyubiquitin binding GO:0031625 ubiquitin protein ligase binding GO:0032041 NAD-dependent histone deacetylase activity (H3-K14 specific) GO:0032182 ubiquitin-like protein binding GO:0033558 protein deacetylase activity GO:0034979 NAD-dependent protein deacetylase activity GO:0042826 histone deacetylase binding GO:0042903 tubulin deacetylase activity GO:0043014 alpha-tubulin binding GO:0043130 ubiquitin binding GO:0044389 ubiquitin-like protein ligase binding GO:0048156 tau protein binding GO:0048487 beta-tubulin binding GO:0051787 misfolded protein binding GO:0051879 Hsp90 protein binding GO:0070840 dynein complex binding
Cellular Component	GO:0000118 histone deacetylase complex GO:0005770 late endosome GO:0005771 multivesicular body GO:0005874 microtubule GO:0005875 microtubule associated complex GO:0005881 cytoplasmic microtubule GO:0005901 caveola GO:0016234 inclusion body GO:0016235 aggresome GO:0030286 dynein complex GO:0030424 axon GO:0030425 dendrite GO:0031252 cell leading edge GO:0043025 neuronal cell body GO:0043204 perikaryon GO:0044297 cell body GO:0044853 plasma membrane raft GO:0045121 membrane raft GO:0098589 membrane region GO:0098857 membrane microdomain

> KEGG and Reactome Pathway [ TOP ]
KEGG	-
Reactome	R-HSA-3371556: Cellular response to heat stress R-HSA-2262752: Cellular responses to stress R-HSA-5617833: Cilium Assembly R-HSA-2894862: Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2644606: Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-1643685: Disease R-HSA-5663202: Diseases of signal transduction R-HSA-3371511: HSF1 activation R-HSA-2122947: NOTCH1 Intracellular Domain Regulates Transcription R-HSA-1852241: Organelle biogenesis and maintenance R-HSA-162582: Signal Transduction R-HSA-157118: Signaling by NOTCH R-HSA-1980143: Signaling by NOTCH1 R-HSA-2894858: Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2644602: Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644603: Signaling by NOTCH1 in Cancer

> KEGG and Reactome Pathway

[ TOP ]

KEGG

Reactome

R-HSA-3371556: Cellular response to heat stress
R-HSA-2262752: Cellular responses to stress
R-HSA-5617833: Cilium Assembly
R-HSA-2894862: Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
R-HSA-2644606: Constitutive Signaling by NOTCH1 PEST Domain Mutants
R-HSA-1643685: Disease
R-HSA-5663202: Diseases of signal transduction
R-HSA-3371511: HSF1 activation
R-HSA-2122947: NOTCH1 Intracellular Domain Regulates Transcription
R-HSA-1852241: Organelle biogenesis and maintenance
R-HSA-162582: Signal Transduction
R-HSA-157118: Signaling by NOTCH
R-HSA-1980143: Signaling by NOTCH1
R-HSA-2894858: Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer
R-HSA-2644602: Signaling by NOTCH1 PEST Domain Mutants in Cancer
R-HSA-2644603: Signaling by NOTCH1 in Cancer

Summary
Symbol	HDAC6
Name	histone deacetylase 6
Aliases	KIAA0901; JM21; FLJ16239; PPP1R90; protein phosphatase 1, regulatory subunit 90; CPBHM
Location	Xp11.23
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Mutation landscape in primary tumor tissue from TCGA > Mutation landscape in cancer cell line from CCLE > All mutations from COSMIC database V81 > Variations from text mining

> The Cancer Genome Atlas (TCGA) [ TOP ]

> Cancer Cell Line Encyclopedia (CCLE) [ TOP ]

> Catalogue of Somatic Mutations in Cancer (COSMIC)

[ TOP ]

COSMIC ID	CDS change	AA change	Mutation Type	Anatomical Site
COSM4651714	c.2924C>T	p.T975M	Substitution - Missense	Large_intestine
COSM4950011	c.645T>G	p.H215Q	Substitution - Missense	Liver
COSM1122197	c.2126G>A	p.R709H	Substitution - Missense	Endometrium
COSM488407	c.1554C>T	p.G518G	Substitution - coding silent	Kidney
COSM4950011	c.645T>G	p.H215Q	Substitution - Missense	Liver
COSM4109806	c.2293C>A	p.L765M	Substitution - Missense	Stomach
COSM1468255	c.2247delG	p.G751fs*16	Deletion - Frameshift	Large_intestine
COSM3364024	c.2930G>A	p.G977D	Substitution - Missense	Kidney
COSM1468257	c.3040G>A	p.G1014R	Substitution - Missense	Large_intestine
COSM1132294	c.1698T>G	p.F566L	Substitution - Missense	Prostate
COSM5819635	c.482A>T	p.E161V	Substitution - Missense	Liver
COSM1491017	c.3469A>G	p.I1157V	Substitution - Missense	Breast
COSM1122178	c.98G>A	p.R33Q	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM311726	c.2409A>C	p.P803P	Substitution - coding silent	Urinary_tract
COSM380039	c.1527G>C	p.R509R	Substitution - coding silent	Lung
COSM6008697	c.2909C>A	p.A970D	Substitution - Missense	Prostate
COSM3786739	c.514G>A	p.D172N	Substitution - Missense	Pancreas
COSM5620939	c.1855G>A	p.G619S	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM3561980	c.2460C>T	p.I820I	Substitution - coding silent	Skin
COSM1122192	c.1728C>T	p.F576F	Substitution - coding silent	Large_intestine
COSM1122196	c.2122C>T	p.P708S	Substitution - Missense	Endometrium
COSM1468253	c.1374C>T	p.S458S	Substitution - coding silent	Large_intestine
COSM4766205	c.1808C>T	p.A603V	Substitution - Missense	Stomach
COSM3561974	c.379C>T	p.R127C	Substitution - Missense	Skin
COSM1662107	c.1703C>A	p.S568Y	Substitution - Missense	Kidney
COSM3379637	c.2325C>T	p.I775I	Substitution - coding silent	Pancreas
COSM1122195	c.1867T>C	p.F623L	Substitution - Missense	Endometrium
COSM4836296	c.1521C>G	p.I507M	Substitution - Missense	Cervix
COSM3844864	c.2609G>A	p.R870Q	Substitution - Missense	Breast
COSM3364024	c.2930G>A	p.G977D	Substitution - Missense	Kidney
COSM1122202	c.2532A>G	p.G844G	Substitution - coding silent	Endometrium
COSM5695705	c.2364A>C	p.S788S	Substitution - coding silent	Soft_tissue
COSM4109794	c.789C>T	p.T263T	Substitution - coding silent	Stomach
COSM3561978	c.1782C>T	p.L594L	Substitution - coding silent	Skin
COSM1122205	c.3049G>A	p.E1017K	Substitution - Missense	Endometrium
COSM1122180	c.533C>T	p.P178L	Substitution - Missense	Endometrium
COSM4510144	c.828C>T	p.H276H	Substitution - coding silent	Skin
COSM4968290	c.1459C>G	p.Q487E	Substitution - Missense	Adrenal_gland
COSM311726	c.2409A>C	p.P803P	Substitution - coding silent	Skin
COSM261230	c.3129G>T	p.Q1043H	Substitution - Missense	Large_intestine
COSM3708643	c.3132A>G	p.I1044M	Substitution - Missense	Liver
COSM2966616	c.3203C>T	p.S1068F	Substitution - Missense	Oesophagus
COSM374857	c.3074C>T	p.S1025L	Substitution - Missense	Lung
COSM5475345	c.2510T>C	p.M837T	Substitution - Missense	Large_intestine
COSM1122186	c.1182C>T	p.G394G	Substitution - coding silent	Endometrium
COSM4005133	c.2883T>G	p.I961M	Substitution - Missense	Urinary_tract
COSM311724	c.1585C>T	p.R529C	Substitution - Missense	Lung
COSM1122204	c.2829C>T	p.V943V	Substitution - coding silent	Endometrium
COSM1122203	c.2611G>T	p.E871*	Substitution - Nonsense	Endometrium
COSM3844852	c.857A>C	p.H286P	Substitution - Missense	Breast
COSM3992513	c.3288G>A	p.R1096R	Substitution - coding silent	Kidney
COSM5799457	c.807-1G>T	p.?	Unknown	Breast
COSM3713909	c.3095C>T	p.P1032L	Substitution - Missense	Upper_aerodigestive_tract
COSM5515867	c.401G>A	p.R134Q	Substitution - Missense	Biliary_tract
COSM4109792	c.246A>G	p.A82A	Substitution - coding silent	Stomach
COSM1625944	c.3436C>T	p.L1146F	Substitution - Missense	Liver
COSM4689693	c.3091_3092insC	p.T1034fs*55	Insertion - Frameshift	Breast
COSM5793057	c.829C>T	p.R277C	Substitution - Missense	Breast
COSM3561976	c.1476C>T	p.H492H	Substitution - coding silent	Skin
COSM1122185	c.1121C>T	p.A374V	Substitution - Missense	Endometrium
COSM5698684	c.3077G>T	p.S1026I	Substitution - Missense	Soft_tissue
COSM5557367	c.1707C>T	p.I569I	Substitution - coding silent	Prostate
COSM1122187	c.1194G>A	p.S398S	Substitution - coding silent	Endometrium
COSM4109804	c.2264C>T	p.S755L	Substitution - Missense	Stomach
COSM261229	c.134C>A	p.P45H	Substitution - Missense	Large_intestine
COSM1161969	c.1765C>A	p.L589M	Substitution - Missense	Kidney
COSM355803	c.265G>T	p.V89L	Substitution - Missense	Lung
COSM281634	c.3463C>T	p.R1155C	Substitution - Missense	Large_intestine
COSM3701867	c.2902G>T	p.E968*	Substitution - Nonsense	Liver
COSM5787189	c.3625G>T	p.E1209*	Substitution - Nonsense	Breast
COSM3844854	c.1855G>T	p.G619C	Substitution - Missense	Breast
COSM1756604	c.2907T>G	p.D969E	Substitution - Missense	Urinary_tract
COSM4005135	c.2888A>G	p.D963G	Substitution - Missense	Urinary_tract
COSM4414063	c.2141A>G	p.D714G	Substitution - Missense	Kidney
COSM1122178	c.98G>A	p.R33Q	Substitution - Missense	Endometrium
COSM3786739	c.514G>A	p.D172N	Substitution - Missense	Large_intestine
COSM5742267	c.3207G>T	p.Q1069H	Substitution - Missense	Small_intestine
COSM1132295	c.1102C>T	p.H368Y	Substitution - Missense	Prostate
COSM5787678	c.1847C>T	p.A616V	Substitution - Missense	Breast
COSM5711684	c.3365T>C	p.I1122T	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM380038	c.671G>T	p.G224V	Substitution - Missense	Lung
COSM1122184	c.1072G>A	p.A358T	Substitution - Missense	Endometrium
COSM6018467	c.765C>T	p.H255H	Substitution - coding silent	Skin
COSM3844862	c.2601G>A	p.M867I	Substitution - Missense	Breast
COSM1122189	c.1657A>C	p.K553Q	Substitution - Missense	Endometrium
COSM97849	c.619A>T	p.M207L	Substitution - Missense	Upper_aerodigestive_tract
COSM311726	c.2409A>C	p.P803P	Substitution - coding silent	Central_nervous_system
COSM4656493	c.11C>T	p.T4I	Substitution - Missense	Large_intestine
COSM1625942	c.1973A>T	p.H658L	Substitution - Missense	Liver
COSM1122200	c.2483G>A	p.R828H	Substitution - Missense	Endometrium
COSM457593	c.208G>A	p.G70R	Substitution - Missense	Breast
COSM311725	c.59C>G	p.P20R	Substitution - Missense	Lung
COSM3844860	c.2536T>A	p.S846T	Substitution - Missense	Breast
COSM3780495	c.1256+9C>T	p.?	Unknown	Pancreas
COSM3561974	c.379C>T	p.R127C	Substitution - Missense	Skin
COSM2966595	c.1561G>A	p.G521R	Substitution - Missense	Large_intestine
COSM4109798	c.1183G>A	p.V395I	Substitution - Missense	Stomach
COSM1625943	c.1974C>A	p.H658Q	Substitution - Missense	Liver
COSM5959629	c.3600C>A	p.N1200K	Substitution - Missense	Thyroid
COSM1122207	c.3542C>T	p.A1181V	Substitution - Missense	Endometrium
COSM5412756	c.2068C>T	p.Q690*	Substitution - Nonsense	Skin
COSM4525521	c.1336G>A	p.E446K	Substitution - Missense	Skin
COSM4689693	c.3091_3092insC	p.T1034fs*55	Insertion - Frameshift	Breast
COSM3406422	c.178G>A	p.G60S	Substitution - Missense	Central_nervous_system
COSM5907797	c.2486G>A	p.R829K	Substitution - Missense	Skin
COSM457598	c.3181G>A	p.E1061K	Substitution - Missense	Endometrium
COSM311723	c.2800C>T	p.L934L	Substitution - coding silent	Soft_tissue
COSM1122190	c.1682G>A	p.R561H	Substitution - Missense	Endometrium
COSM1625940	c.388T>A	p.S130T	Substitution - Missense	Liver
COSM5965920	c.1170C>A	p.A390A	Substitution - coding silent	Breast
COSM1122192	c.1728C>T	p.F576F	Substitution - coding silent	Large_intestine
COSM4109802	c.1531A>G	p.M511V	Substitution - Missense	Stomach
COSM457599	c.3318T>C	p.A1106A	Substitution - coding silent	Breast
COSM5711682	c.3118A>C	p.T1040P	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM1209390	c.649G>A	p.A217T	Substitution - Missense	Large_intestine
COSM1122191	c.1716C>T	p.C572C	Substitution - coding silent	Endometrium
COSM1468253	c.1374C>T	p.S458S	Substitution - coding silent	Large_intestine
COSM3973701	c.3424A>G	p.N1142D	Substitution - Missense	Central_nervous_system
COSM1122181	c.853C>A	p.P285T	Substitution - Missense	Endometrium
COSM422552	c.3040G>T	p.G1014W	Substitution - Missense	Urinary_tract
COSM1625941	c.1155C>G	p.G385G	Substitution - coding silent	Liver
COSM1122198	c.2162G>A	p.R721H	Substitution - Missense	Endometrium
COSM1122199	c.2370C>T	p.S790S	Substitution - coding silent	Endometrium
COSM1468256	c.2273G>T	p.G758V	Substitution - Missense	Large_intestine
COSM3786739	c.514G>A	p.D172N	Substitution - Missense	Pancreas
COSM311726	c.2409A>C	p.P803P	Substitution - coding silent	Lung
COSM6005091	c.738-7C>A	p.?	Unknown	Prostate
COSM4689691	c.2299A>T	p.M767L	Substitution - Missense	Large_intestine
COSM3561984	c.2884C>T	p.L962L	Substitution - coding silent	Skin
COSM77837	c.2242C>A	p.P748T	Substitution - Missense	Ovary
COSM1122183	c.899G>A	p.G300D	Substitution - Missense	Endometrium
COSM1491016	c.1806T>A	p.A602A	Substitution - coding silent	Breast
COSM4631917	c.2774C>A	p.S925Y	Substitution - Missense	Large_intestine
COSM457597	c.2518G>C	p.E840Q	Substitution - Missense	Breast
COSM1122192	c.1728C>T	p.F576F	Substitution - coding silent	Skin
COSM5513793	c.2634C>T	p.G878G	Substitution - coding silent	Biliary_tract
COSM5436886	c.1633G>A	p.V545M	Substitution - Missense	Oesophagus
COSM79963	c.1522T>C	p.L508L	Substitution - coding silent	Ovary
COSM5787714	c.1546G>A	p.E516K	Substitution - Missense	Breast
COSM3844852	c.857A>C	p.H286P	Substitution - Missense	Breast
COSM1625944	c.3436C>T	p.L1146F	Substitution - Missense	Liver
COSM1122188	c.1298C>T	p.P433L	Substitution - Missense	Endometrium
COSM4689693	c.3091_3092insC	p.T1034fs*55	Insertion - Frameshift	Large_intestine
COSM1491015	c.846G>T	p.R282S	Substitution - Missense	Breast
COSM360609	c.3624G>T	p.G1208G	Substitution - coding silent	Lung
COSM1122182	c.891C>T	p.F297F	Substitution - coding silent	Endometrium
COSM2966610	c.2504G>A	p.R835Q	Substitution - Missense	Stomach
COSM4689693	c.3091_3092insC	p.T1034fs*55	Insertion - Frameshift	Large_intestine
COSM5476916	c.3484C>T	p.L1162F	Substitution - Missense	Large_intestine
COSM457595	c.855C>T	p.P285P	Substitution - coding silent	Breast
COSM1122182	c.891C>T	p.F297F	Substitution - coding silent	Large_intestine
COSM5577495	c.3395C>T	p.P1132L	Substitution - Missense	Skin
COSM79962	c.439C>T	p.L147L	Substitution - coding silent	Ovary
COSM5796381	c.1926G>A	p.R642R	Substitution - coding silent	Breast
COSM4589446	c.2237G>T	p.G746V	Substitution - Missense	Bone
COSM2966623	c.3376G>T	p.G1126C	Substitution - Missense	Central_nervous_system
COSM5412754	c.1366G>A	p.E456K	Substitution - Missense	Skin
COSM5677566	c.3421G>C	p.E1141Q	Substitution - Missense	Soft_tissue
COSM1315553	c.3344A>G	p.H1115R	Substitution - Missense	Urinary_tract
COSM1743475	c.627C>T	p.I209I	Substitution - coding silent	Biliary_tract
COSM5989454	c.2126G>T	p.R709L	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM1122201	c.2512A>C	p.K838Q	Substitution - Missense	Endometrium
COSM6008695	c.2585G>A	p.R862K	Substitution - Missense	Prostate
COSM5412750	c.291C>T	p.F97F	Substitution - coding silent	Skin
COSM2966582	c.384C>T	p.C128C	Substitution - coding silent	Breast
COSM2966575	c.133C>T	p.P45S	Substitution - Missense	Oesophagus
COSM1714932	c.2012T>G	p.L671R	Substitution - Missense	Skin
COSM1756603	c.2874A>G	p.G958G	Substitution - coding silent	Urinary_tract
COSM135945	c.1246C>T	p.P416S	Substitution - Missense	Skin
COSM5682664	c.1652C>A	p.T551K	Substitution - Missense	Soft_tissue
COSM5617561	c.933+5G>A	p.?	Unknown	Lung
COSM4109800	c.1499A>G	p.H500R	Substitution - Missense	Stomach
COSM1582896	c.2892G>T	p.Q964H	Substitution - Missense	Meninges
COSM1122192	c.1728C>T	p.F576F	Substitution - coding silent	Endometrium
COSM3844866	c.2726A>T	p.Q909L	Substitution - Missense	Breast
COSM4462011	c.122C>T	p.P41L	Substitution - Missense	Skin
COSM3965299	c.3509A>C	p.H1170P	Substitution - Missense	Lung
COSM5002616	c.1277G>A	p.C426Y	Substitution - Missense	Pancreas
COSM5711949	c.3245G>C	p.G1082A	Substitution - Missense	Soft_tissue
COSM4109796	c.1122A>G	p.A374A	Substitution - coding silent	Stomach
COSM1138157	c.1776T>A	p.A592A	Substitution - coding silent	Kidney
COSM1468255	c.2247delG	p.G751fs*16	Deletion - Frameshift	Breast
COSM4689695	c.3572A>G	p.H1191R	Substitution - Missense	Large_intestine
COSM4516234	c.1717_1718CC>TT	p.P573F	Substitution - Missense	Skin
COSM1666171	c.1834G>T	p.A612S	Substitution - Missense	Eye
COSM1122193	c.1751G>A	p.G584D	Substitution - Missense	Endometrium
COSM4959260	c.2917G>A	p.G973R	Substitution - Missense	Liver
COSM488406	c.1529T>C	p.I510T	Substitution - Missense	Kidney
COSM457594	c.552C>A	p.A184A	Substitution - coding silent	Breast
COSM385733	c.1888G>A	p.A630T	Substitution - Missense	Lung
COSM3735339	c.3353C>T	p.A1118V	Substitution - Missense	Skin
COSM4149085	c.1637G>C	p.G546A	Substitution - Missense	Ovary
COSM457598	c.3181G>A	p.E1061K	Substitution - Missense	Breast
COSM1122206	c.3512C>T	p.P1171L	Substitution - Missense	Endometrium
COSM2966602	c.1849G>A	p.A617T	Substitution - Missense	Large_intestine
COSM3914035	c.637C>A	p.P213T	Substitution - Missense	Skin
COSM1331836	c.2272G>A	p.G758S	Substitution - Missense	Ovary
COSM1209390	c.649G>A	p.A217T	Substitution - Missense	Stomach
COSM4520538	c.1063G>A	p.E355K	Substitution - Missense	Skin
COSM3844858	c.2291A>C	p.H764P	Substitution - Missense	Breast
COSM1132293	c.1699G>C	p.D567H	Substitution - Missense	Prostate
COSM5513791	c.1737A>G	p.A579A	Substitution - coding silent	Biliary_tract
COSM5779281	c.2211C>T	p.V737V	Substitution - coding silent	Breast
COSM6018470	c.1392G>A	p.W464*	Substitution - Nonsense	Skin
COSM2966588	c.1308G>T	p.E436D	Substitution - Missense	Large_intestine
COSM4746132	c.3013G>T	p.D1005Y	Substitution - Missense	Central_nervous_system
COSM5457947	c.2783C>T	p.A928V	Substitution - Missense	Large_intestine
COSM1331835	c.3244G>A	p.G1082R	Substitution - Missense	Ovary
COSM4156876	c.1504G>T	p.E502*	Substitution - Nonsense	Thyroid
COSM5513795	c.2967A>G	p.T989T	Substitution - coding silent	Biliary_tract
COSM1122194	c.1761C>T	p.C587C	Substitution - coding silent	Endometrium
COSM1285332	c.3606C>A	p.A1202A	Substitution - coding silent	Autonomic_ganglia
COSM3844856	c.1889C>T	p.A630V	Substitution - Missense	Breast
COSM1625942	c.1973A>T	p.H658L	Substitution - Missense	Liver
COSM5039317	c.3580-1G>A	p.?	Unknown	Liver
COSM488405	c.1519A>G	p.I507V	Substitution - Missense	Kidney
COSM1209389	c.1514A>C	p.Q505P	Substitution - Missense	Large_intestine
COSM4837668	c.2984C>T	p.S995L	Substitution - Missense	Cervix
COSM422553	c.707G>T	p.R236L	Substitution - Missense	Urinary_tract
COSM4156878	c.1538G>A	p.R513H	Substitution - Missense	Thyroid
COSM1173588	c.1924C>T	p.R642W	Substitution - Missense	Oesophagus
COSM4772077	c.1402G>C	p.V468L	Substitution - Missense	Stomach
COSM311723	c.2800C>T	p.L934L	Substitution - coding silent	Lung
COSM1570146	c.2076C>A	p.G692G	Substitution - coding silent	Large_intestine
COSM3561982	c.2850G>A	p.Q950Q	Substitution - coding silent	Skin
COSM488408	c.2562G>A	p.K854K	Substitution - coding silent	Kidney
COSM4419124	c.2265A>G	p.S755S	Substitution - coding silent	Haematopoietic_and_lymphoid_tissue
COSM4689693	c.3091_3092insC	p.T1034fs*55	Insertion - Frameshift	Large_intestine
COSM4959260	c.2917G>A	p.G973R	Substitution - Missense	Liver
COSM5711949	c.3245G>C	p.G1082A	Substitution - Missense	Soft_tissue
COSM3786741	c.976G>A	p.V326I	Substitution - Missense	Pancreas
COSM5794295	c.1599G>A	p.E533E	Substitution - coding silent	Breast
COSM4492096	c.390C>T	p.S130S	Substitution - coding silent	Skin
COSM4589448	c.3051G>A	p.E1017E	Substitution - coding silent	Bone
COSM403500	c.1381G>A	p.E461K	Substitution - Missense	Lung
COSM1625943	c.1974C>A	p.H658Q	Substitution - Missense	Liver
COSM1122177	c.92C>T	p.S31L	Substitution - Missense	Endometrium
COSM1190968	c.546_547delCT	p.A184fs*18	Deletion - Frameshift	Lung
COSM1169197	c.144G>A	p.A48A	Substitution - coding silent	Pancreas
COSM5729678	c.3635C>T	p.P1212L	Substitution - Missense	Skin
COSM3713909	c.3095C>T	p.P1032L	Substitution - Missense	Upper_aerodigestive_tract
COSM457596	c.1699G>T	p.D567Y	Substitution - Missense	Breast
COSM1122176	c.41G>A	p.R14Q	Substitution - Missense	Endometrium
COSM1122179	c.477G>T	p.M159I	Substitution - Missense	Endometrium
COSM1625941	c.1155C>G	p.G385G	Substitution - coding silent	Liver
COSM2966592	c.1422G>A	p.W474*	Substitution - Nonsense	Large_intestine
COSM1625940	c.388T>A	p.S130T	Substitution - Missense	Liver
COSM4650874	c.1168G>A	p.A390T	Substitution - Missense	Large_intestine
COSM1163567	c.2116A>G	p.N706D	Substitution - Missense	Pancreas
COSM97849	c.619A>T	p.M207L	Substitution - Missense	Upper_aerodigestive_tract
COSM4109809	c.2962G>A	p.A988T	Substitution - Missense	Stomach
COSM5625407	c.927G>C	p.W309C	Substitution - Missense	Oesophagus
COSM5642018	c.2639G>T	p.G880V	Substitution - Missense	Oesophagus

> Text Mining based Variations [ TOP ]
There is no record for HDAC6.

Summary
Symbol	HDAC6
Name	histone deacetylase 6
Aliases	KIAA0901; JM21; FLJ16239; PPP1R90; protein phosphatase 1, regulatory subunit 90; CPBHM
Location	Xp11.23
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Post-translational modification (PTM)

> Post-translational modification (PTM)

[ TOP ]

Filter By:

Uniprot ID	Position	Amino Acid	Description	Upstream Enzyme	Affected By Mutation	Amino Acid Sequence Variant
Q9UBN7	33	R	Omega-N-methylarginine	-	Yes	p.R33Q (cancer: UCEC)
Q9UBN7	1016	T	Phosphothreonine	-	No	None detected
Q9UBN7	1021	T	Phosphothreonine	-	No	None detected
Q9UBN7	1027	T	Phosphothreonine	-	No	None detected
Q9UBN7	1031	T	Phosphothreonine	-	Yes	p.T1031fs (cancer: BRCA, STAD)
Q9UBN7	1034	T	Phosphothreonine	-	No	None detected
Q9UBN7	1035	S	Phosphoserine	-	No	None detected
Q9UBN7	1040	T	Phosphothreonine	-	No	None detected

Summary
Symbol	HDAC6
Name	histone deacetylase 6
Aliases	KIAA0901; JM21; FLJ16239; PPP1R90; protein phosphatase 1, regulatory subunit 90; CPBHM
Location	Xp11.23
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Expression analysis in primary tumor tissue from TCGA > Expression level in cancer cell line from CCLE > Expression level in human normal tissue from HPA > Text mining based expression change

> The Cancer Genome Atlas (TCGA)

[ TOP ]

Differential expression analysis for cancers with more than 10 normal samples

Cancer	Full Name	# N	# T	Median (N)	Median (T)	LogFC	Adj. P	Status
BLCA	Bladder urothelial carcinoma	19	408	5.095	5.719	0.519	0.000248	NS
BRCA	Breast invasive carcinoma	112	1100	5.802	5.757	-0.013	0.777	NS
CESC	Cervical and endocervical cancers	3	306	5.339	5.878	NA	NA	NA
COAD	Colon adenocarcinoma	41	459	5.737	5.611	-0.036	0.717	NS
ESCA	Esophageal carcinoma	11	185	5.434	5.416	0.041	0.869	NS
GBM	Glioblastoma multiforme	5	166	6.08	6.298	NA	NA	NA
HNSC	Head and Neck squamous cell carcinoma	44	522	5.425	5.05	-0.349	1.48e-05	NS
KIRC	Kidney renal clear cell carcinoma	72	534	6.662	6.489	-0.253	0.000455	NS
KIRP	Kidney renal papillary cell carcinoma	32	291	7.135	6.473	-0.642	4.7e-08	Under
LAML	Acute Myeloid Leukemia	0	173	NA	6.739	NA	NA	NA
LGG	Brain Lower Grade Glioma	0	530	NA	6.692	NA	NA	NA
LIHC	Liver hepatocellular carcinoma	50	373	6.969	6.043	-0.856	9.32e-12	Under
LUAD	Lung adenocarcinoma	59	517	5.728	5.795	0.095	0.229	NS
LUSC	Lung squamous cell carcinoma	51	501	5.703	5.499	-0.159	0.0641	NS
OV	Ovarian serous cystadenocarcinoma	0	307	NA	5.982	NA	NA	NA
PAAD	Pancreatic adenocarcinoma	4	179	5.958	5.666	NA	NA	NA
PCPG	Pheochromocytoma and Paraganglioma	3	184	5.843	5.876	NA	NA	NA
PRAD	Prostate adenocarcinoma	52	498	5.533	5.691	0.146	0.00512	NS
READ	Rectum adenocarcinoma	10	167	5.468	5.693	0.401	0.0325	NS
SARC	Sarcoma	2	263	5.842	5.965	NA	NA	NA
SKCM	Skin Cutaneous Melanoma	1	472	5.375	5.903	NA	NA	NA
STAD	Stomach adenocarcinoma	35	415	5.356	5.342	0.116	0.269	NS
TGCT	Testicular Germ Cell Tumors	0	156	NA	6.559	NA	NA	NA
THCA	Thyroid carcinoma	59	509	6.049	5.856	-0.139	0.00017	NS
THYM	Thymoma	2	120	6.615	6.306	NA	NA	NA
UCEC	Uterine Corpus Endometrial Carcinoma	35	546	5.694	5.943	0.283	0.00693	NS

> Cancer Cell Line Encyclopedia (CCLE) [ TOP ]
There is no record.

> The Human Protein Atlas (HPA)

[ TOP ]

Tissue	Expression Level (TPM)
Adipose tissue	19.6
Adrenal gland	17.7
Appendix	21.9
Bone marrow	16.4
Breast	16.7
Cerebral cortex	35.1
Cervix, uterine	19.6
Colon	17.5
Duodenum	19.6
Endometrium	28.4
Epididymis	13.2
Esophagus	16.4
Fallopian tube	28.9
Gallbladder	19.9
Heart muscle	8.3
Kidney	40.3
Liver	22.5
Lung	28.2
Lymph node	18.5
Ovary	23.5
Pancreas	3.5
Parathyroid gland	50.4
Placenta	21.6
Prostate	17.9
Rectum	19.6
Salivary gland	6.9
Seminal vesicle	19.7
Skeletal muscle	7.6
Skin	14.2
Small intestine	21.6
Smooth muscle	25.5
Spleen	24.6
Stomach	14.5
Testis	47.9
Thyroid gland	28.2
Tonsil	17.1
Urinary bladder	15.2

> Text Mining based Expression

[ TOP ]

PMID	Expression	Cancer	Evidence
28700998	underexpression	Gastric Carcinoma	Higher levels of HDAC6 expression were detected in normal and premalignant lesions than in the GC tissues (p<0.01), and decreased HDAC6 expression was associated with HP infection and TNM stage (p<0.01 and p=0.048, respectively).
25548579	Overexpression	Breast Carcinoma	High expression of HDAC6 was correlated with a younger age (p<0.001), ER expression (p=0.025), progesterone receptor expression (p=0.034), molecular subtype (p=0.023), and HER2 amplification (p=0.011).
25791281	Underexpression	Glioma	Among all patients studied, the expression of HDAC1 and HDAC3 was inversely correlated with survival, whereas the expression of HDAC4, HDAC5, HDAC6, HDAC11 and SIRT1 was significantly and positively correlated with survival time of patients with gliomas.
27506904	Overexpression	Renal Cell Carcinoma	Our analysis of tumor and matched non-tumor tissues from radical nephrectomies showed overexpression of class I and II HDACs (HDAC6 only in a subset of patients).
27267806	Overexpression	Glioblastoma	Here, we report that HDAC6 is overexpressed in glioblastoma tissues and cell lines.
27221381	Overexpression	Lung Adenocarcinoma	In the present study, HDAC6 was found to be overexpressed in lung adenocarcinoma cell lines and was negatively correlated with the prognosis of patients with lung adenocarcinoma.
26086159	Underexpression	Hepatocellular Carcinoma	ur experiments showed HDAC6 was significantly downregulated in HCC tissues (P = 0.025), and low expression of HDAC6 was found to be closely associated with recurrence (P = 0.006), and could predict poor recurrence-free survival (P = 0.047) for HCC patients with LT.
25111897	Overexpression	Gastric Carcinoma	Aberrant HDAC6 overexpression was observed in a subset of human gastric cancer cells.
24264142	Overexpression	Pancreatic Carcinoma	In this study, we find that histone deacetylase 6 (HDAC6), a member of the class II HDAC family, is highly expressed at both protein and mRNA levels in human pancreatic cancer tissues. HDAC6 does not obviously affect pancreatic cancer cell proliferation or cell cycle progression.
23402884	Overexpression	Hepatocellular Carcinoma	In the present study, we found that mRNA and protein levels of HDAC6 were up-regulated in HCC tissues and cell lines.
22967444	Overexpression	Laryngeal Squamous Cell Carcinoma	There was a high level expression of HDAC6 protein in laryngeal squamous cell carcinoma, and its expression was not related to age and sex of the patients (P > 0.05), but closely associated with the degree of histological differentiation, TNM staging and lymph node metastasis (P < 0.05).
22766642	Overexpression	Hepatocellular Carcinoma	Overexpression of HDAC6 protein to a level higher than that in the corresponding normal hepatocytes was observed in 14 (20%) of the 70 primary HCCs, and was significantly correlated with high clinical stage, number of tumors, vascular invasion and intrahepatic metastasis (P<0.05).
21750953	Underexpression	Cholangiocarcinoma	The expression of HSP70, RB1, and HDAC6 was dominant down-regulation, while the expression of cyclin D1 and HSP90 was dominant up-regulation. A significant association was found between HDAC6 and CCA staging (p=0.000), CCA gross type and HSP70 (p=0.046) as well as RB1 expression (p=0.046).

Summary
Symbol	HDAC6
Name	histone deacetylase 6
Aliases	KIAA0901; JM21; FLJ16239; PPP1R90; protein phosphatase 1, regulatory subunit 90; CPBHM
Location	Xp11.23
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Somatic copy number alteration in primary tomur tissue

> The Cancer Genome Atlas (TCGA)

[ TOP ]

Correlation between expression and SCNA as well as percentage of patients in different status.

Cancer	Full Name	# Sample	R	P	% Loss	% Neutral	% Gain	Status
BLCA	Bladder urothelial carcinoma	404	0.256	1.76e-07	20.3	62.4	17.3	Neutral
BRCA	Breast invasive carcinoma	1075	0.228	4.29e-14	16.7	66.7	16.6	Neutral
CESC	Cervical and endocervical cancers	292	0.188	0.00127	23.6	62.7	13.7	Neutral
COAD	Colon adenocarcinoma	449	0.081	0.0866	15.6	68.8	15.6	Neutral
ESCA	Esophageal carcinoma	183	0.453	1.22e-10	36.6	50.8	12.6	Loss
GBM	Glioblastoma multiforme	147	-0.086	0.302	24.5	72.8	2.7	Neutral
HNSC	Head and Neck squamous cell carcinoma	514	0.283	6.12e-11	28.4	63.4	8.2	Neutral
KIRC	Kidney renal clear cell carcinoma	525	0.204	2.36e-06	9	85.3	5.7	Neutral
KIRP	Kidney renal papillary cell carcinoma	288	0.14	0.0174	11.5	55.9	32.6	Neutral
LAML	Acute Myeloid Leukemia	166	-0.095	0.221	3	95.8	1.2	Neutral
LGG	Brain Lower Grade Glioma	513	-0.007	0.882	18.9	76.2	4.9	Neutral
LIHC	Liver hepatocellular carcinoma	364	-0.047	0.369	27.2	62.4	10.4	Neutral
LUAD	Lung adenocarcinoma	512	0.387	1.03e-19	20.1	67.8	12.1	Neutral
LUSC	Lung squamous cell carcinoma	498	0.282	1.43e-10	26.5	59.2	14.3	Neutral
OV	Ovarian serous cystadenocarcinoma	300	0.525	1.09e-22	43.7	28.3	28	Loss
PAAD	Pancreatic adenocarcinoma	177	0.276	0.000203	14.7	80.2	5.1	Neutral
PCPG	Pheochromocytoma and Paraganglioma	162	0.249	0.00137	27.2	67.9	4.9	Neutral
PRAD	Prostate adenocarcinoma	491	-0.005	0.91	5.5	90.8	3.7	Neutral
READ	Rectum adenocarcinoma	164	0.193	0.0135	18.3	63.4	18.3	Neutral
SARC	Sarcoma	255	0.341	2.34e-08	19.6	45.1	35.3	Gain
SKCM	Skin Cutaneous Melanoma	367	-0.052	0.32	23.2	62.4	14.4	Neutral
STAD	Stomach adenocarcinoma	413	0.206	2.55e-05	14.5	72.6	12.8	Neutral
TGCT	Testicular Germ Cell Tumors	150	0.136	0.0972	18.7	63.3	18	Neutral
THCA	Thyroid carcinoma	497	-0.072	0.11	0.8	97.6	1.6	Neutral
THYM	Thymoma	119	0.159	0.0841	6.7	91.6	1.7	Neutral
UCEC	Uterine Corpus Endometrial Carcinoma	537	0.224	1.52e-07	11.4	72.4	16.2	Neutral

Summary
Symbol	HDAC6
Name	histone deacetylase 6
Aliases	KIAA0901; JM21; FLJ16239; PPP1R90; protein phosphatase 1, regulatory subunit 90; CPBHM
Location	Xp11.23
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Methylation level in the promoter region of CR

> Methylation level in the promoter region of CR

[ TOP ]

Correlation between expression and methylation as well as differential methylation analysis.

Cancer	Full Name	R	P	# N	# T	Delta beta (T vs N)	P value (T vs N)	Status
BLCA	Bladder urothelial carcinoma	-0.298	4.72e-10	17	408	-0.052	0.0845	NS/NA
BRCA	Breast invasive carcinoma	-0.126	0.000196	83	785	-0.091	1.3e-16	NS/NA
CESC	Cervical and endocervical cancers	-0.191	0.000778	3	306	NA	NA	NS/NA
COAD	Colon adenocarcinoma	-0.207	0.00021	19	297	-0.043	0.696	NS/NA
ESCA	Esophageal carcinoma	-0.297	2.84e-05	9	185	NA	NA	NS/NA
GBM	Glioblastoma multiforme	0.004	0.974	1	64	NA	NA	NS/NA
HNSC	Head and Neck squamous cell carcinoma	-0.213	5.75e-07	20	522	0.006	0.917	NS/NA
KIRC	Kidney renal clear cell carcinoma	-0.159	0.00313	24	319	0.003	0.178	NS/NA
KIRP	Kidney renal papillary cell carcinoma	-0.16	0.00563	23	275	0.014	0.244	NS/NA
LAML	Acute Myeloid Leukemia	-0.091	0.238	0	170	NA	NA	NS/NA
LGG	Brain Lower Grade Glioma	-0.103	0.0175	0	530	NA	NA	NS/NA
LIHC	Liver hepatocellular carcinoma	-0.171	5e-04	41	373	-0.003	0.336	NS/NA
LUAD	Lung adenocarcinoma	-0.015	0.745	21	456	0.063	0.301	NS/NA
LUSC	Lung squamous cell carcinoma	-0.19	0.000201	8	370	NA	NA	NS/NA
OV	Ovarian serous cystadenocarcinoma	-0.683	0.0503	0	9	NA	NA	NS/NA
PAAD	Pancreatic adenocarcinoma	-0.06	0.419	4	179	NA	NA	NS/NA
PCPG	Pheochromocytoma and Paraganglioma	-0.225	0.00199	3	184	NA	NA	NS/NA
PRAD	Prostate adenocarcinoma	-0.055	0.204	35	498	0.001	0.00837	NS/NA
READ	Rectum adenocarcinoma	-0.189	0.0591	2	99	NA	NA	NS/NA
SARC	Sarcoma	-0.138	0.0253	0	263	NA	NA	NS/NA
SKCM	Skin Cutaneous Melanoma	-0.073	0.113	1	471	NA	NA	NS/NA
STAD	Stomach adenocarcinoma	-0.391	4.14e-15	0	372	NA	NA	NS/NA
TGCT	Testicular Germ Cell Tumors	-0.226	0.00465	0	156	NA	NA	NS/NA
THCA	Thyroid carcinoma	-0.038	0.374	50	509	-0.021	0.178	NS/NA
THYM	Thymoma	-0.074	0.416	2	120	NA	NA	NS/NA
UCEC	Uterine Corpus Endometrial Carcinoma	-0.264	8.09e-09	34	431	-0.027	0.0118	NS/NA

Summary
Symbol	HDAC6
Name	histone deacetylase 6
Aliases	KIAA0901; JM21; FLJ16239; PPP1R90; protein phosphatase 1, regulatory subunit 90; CPBHM
Location	Xp11.23
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Primary tumor tissue from TCGA > Normal tumor tissue from HPA

>The Cancer Genome Atlas (TCGA) [ TOP ]
There is no record.

> The Human Protein Atlas (HPA)

[ TOP ]

Tissue	Level	Level Name
Adrenal gland	2	Medium
Appendix	2	Medium
Bone marrow	2	Medium
Breast	3	High
Bronchus	2	Medium
Caudate	1	Low
Cerebellum	2	Medium
Cerebral cortex	2	Medium
Cervix, uterine	2	Medium
Colon	2	Medium
Duodenum	2	Medium
Endometrium	2	Medium
Epididymis	2	Medium
Esophagus	1	Low
Fallopian tube	2	Medium
Gallbladder	2	Medium
Heart muscle	1	Low
Hippocampus	0	Not detected
Kidney	2	Medium
Liver	1	Low
Lung	2	Medium
Lymph node	1	Low
Nasopharynx	2	Medium
Oral mucosa	1	Low
Ovary	1	Low
Pancreas	2	Medium
Parathyroid gland	2	Medium
Placenta	2	Medium
Prostate	2	Medium
Rectum	2	Medium
Salivary gland	2	Medium
Seminal vesicle	1	Low
Skeletal muscle	0	Not detected
Skin	3	High
Small intestine	2	Medium
Smooth muscle	0	Not detected
Soft tissue	0	Not detected
Spleen	1	Low
Stomach	2	Medium
Testis	3	High
Thyroid gland	2	Medium
Tonsil	2	Medium
Urinary bladder	2	Medium
Vagina	2	Medium

Summary
Symbol	HDAC6
Name	histone deacetylase 6
Aliases	KIAA0901; JM21; FLJ16239; PPP1R90; protein phosphatase 1, regulatory subunit 90; CPBHM
Location	Xp11.23
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Association between expresson and subtype > Overall survival analysis based on expression > Association between expresson and stage > Association between expresson and grade

> Subtype

[ TOP ]

Association between expresson and subtype.

Cancer	Full Name	# Patients	P Value (Kruskal-Wallis)	Association	Source
BLCA	Bladder urothelial carcinoma	128	0.149	NS	24476821
BRCA	Breast invasive carcinoma	521	0.000329	Significant	23000897
COAD	Colon adenocarcinoma	149	0.000341	Significant	22810696
GBM	Glioblastoma multiforme	157	0.00189	Significant	26824661
HNSC	Head and Neck squamous cell carcinoma	279	3.97e-08	Significant	25631445
KIRP	Kidney renal papillary cell carcinoma	161	0.408	NS	26536169
LGG	Brain Lower Grade Glioma	513	1.13e-16	Significant	26824661
LUAD	Lung adenocarcinoma	230	0.00112	Significant	25079552
LUSC	Lung squamous cell carcinoma	178	4.91e-06	Significant	22960745
OV	Ovarian serous cystadenocarcinoma	287	0.00569	Significant	21720365
PRAD	Prostate adenocarcinoma	333	0.00377	Significant	26544944
READ	Rectum adenocarcinoma	67	0.0338	Significant	22810696
SKCM	Skin Cutaneous Melanoma	315	0.394	NS	26091043
STAD	Stomach adenocarcinoma	277	1.37e-06	Significant	25079317
THCA	Thyroid carcinoma	391	0.84	NS	25417114
UCEC	Uterine Corpus Endometrial Carcinoma	232	0.00281	Significant	23636398

> Overall survival

[ TOP ]

Overall survival analysis based on expression.

Cancer	Full Name	# Patients	Hazard Ratio	P Value (Log Rank Test)	Association
BLCA	Bladder urothelial carcinoma	405	0.559	0.00515	Longer
BRCA	Breast invasive carcinoma	1079	1.13	0.591	NS
CESC	Cervical and endocervical cancers	291	0.608	0.179	NS
COAD	Colon adenocarcinoma	439	1.221	0.494	NS
ESCA	Esophageal carcinoma	184	1.161	0.659	NS
GBM	Glioblastoma multiforme	158	0.899	0.674	NS
HNSC	Head and Neck squamous cell carcinoma	518	0.546	0.00258	Longer
KIRC	Kidney renal clear cell carcinoma	531	0.764	0.172	NS
KIRP	Kidney renal papillary cell carcinoma	287	0.35	0.00638	Longer
LAML	Acute Myeloid Leukemia	149	0.724	0.312	NS
LGG	Brain Lower Grade Glioma	511	0.826	0.474	NS
LIHC	Liver hepatocellular carcinoma	365	0.575	0.0202	Longer
LUAD	Lung adenocarcinoma	502	0.829	0.368	NS
LUSC	Lung squamous cell carcinoma	494	1.082	0.687	NS
OV	Ovarian serous cystadenocarcinoma	303	1.082	0.708	NS
PAAD	Pancreatic adenocarcinoma	177	0.416	0.00372	Longer
PCPG	Pheochromocytoma and Paraganglioma	179	1	1	NS
PRAD	Prostate adenocarcinoma	497	2.138	0.398	NS
READ	Rectum adenocarcinoma	159	1.648	0.419	NS
SARC	Sarcoma	259	2.178	0.0132	Shorter
SKCM	Skin Cutaneous Melanoma	459	1.016	0.936	NS
STAD	Stomach adenocarcinoma	388	0.806	0.36	NS
TGCT	Testicular Germ Cell Tumors	134	0	0.0568	NS
THCA	Thyroid carcinoma	500	1.299	0.732	NS
THYM	Thymoma	119	0	0.000742	Longer
UCEC	Uterine Corpus Endometrial Carcinoma	543	1.473	0.138	NS

> Stage

[ TOP ]

Association between expresson and stage.

Cancer	Full Name	# Patients	R Value (Spearman)	P Value (Spearman)	Association
BLCA	Bladder urothelial carcinoma	406	-0.096	0.0523	NS
BRCA	Breast invasive carcinoma	1071	0.015	0.626	NS
CESC	Cervical and endocervical cancers	167	0	0.996	NS
COAD	Colon adenocarcinoma	445	0.018	0.708	NS
ESCA	Esophageal carcinoma	162	0.011	0.887	NS
HNSC	Head and Neck squamous cell carcinoma	448	-0.015	0.753	NS
KIRC	Kidney renal clear cell carcinoma	531	0.065	0.132	NS
KIRP	Kidney renal papillary cell carcinoma	260	-0.165	0.00784	Lower
LIHC	Liver hepatocellular carcinoma	347	-0.123	0.0221	Lower
LUAD	Lung adenocarcinoma	507	-0.067	0.134	NS
LUSC	Lung squamous cell carcinoma	497	-0.03	0.51	NS
OV	Ovarian serous cystadenocarcinoma	302	-0.089	0.123	NS
PAAD	Pancreatic adenocarcinoma	176	-0.129	0.0867	NS
READ	Rectum adenocarcinoma	156	0.067	0.405	NS
SKCM	Skin Cutaneous Melanoma	410	-0.051	0.303	NS
STAD	Stomach adenocarcinoma	392	-0.143	0.0046	Lower
TGCT	Testicular Germ Cell Tumors	81	-0.255	0.0216	Lower
THCA	Thyroid carcinoma	499	-0.082	0.0671	NS
UCEC	Uterine Corpus Endometrial Carcinoma	501	0.021	0.639	NS

> Grade

[ TOP ]

Association between expresson and grade.

Cancer	Full Name	# Patients	R Value (Spearman)	P Value (Spearman)	Association
CESC	Cervical and endocervical cancers	272	-0.026	0.671	NS
HNSC	Head and Neck squamous cell carcinoma	498	0.147	0.000974	Higher
KIRC	Kidney renal clear cell carcinoma	525	0.019	0.662	NS
LGG	Brain Lower Grade Glioma	514	-0.061	0.168	NS
LIHC	Liver hepatocellular carcinoma	366	-0.312	1.11e-09	Lower
OV	Ovarian serous cystadenocarcinoma	296	0.046	0.43	NS
PAAD	Pancreatic adenocarcinoma	176	-0.034	0.65	NS
STAD	Stomach adenocarcinoma	406	-0.195	7.78e-05	Lower
UCEC	Uterine Corpus Endometrial Carcinoma	534	0.081	0.0625	NS

Summary
Symbol	HDAC6
Name	histone deacetylase 6
Aliases	KIAA0901; JM21; FLJ16239; PPP1R90; protein phosphatase 1, regulatory subunit 90; CPBHM
Location	Xp11.23
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Targets inferred by reverse engineering method > Targets identified by ChIP-seq data

> Targets inferred by reverse engineering method [ TOP ]

> Targets identified by ChIP-seq data [ TOP ]

Summary
Symbol	HDAC6
Name	histone deacetylase 6
Aliases	KIAA0901; JM21; FLJ16239; PPP1R90; protein phosphatase 1, regulatory subunit 90; CPBHM
Location	Xp11.23
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Drugs from DrugBank database

> Drugs from DrugBank database

[ TOP ]

DrugBank ID	Name	Type
DB02546	Vorinostat	Small Molecule Drug
DB05223	SB939	Small Molecule Drug
DB06176	Romidepsin	Small Molecule Drug
DB05015	Belinostat	Small Molecule Drug
DB06603	Panobinostat	Small Molecule Drug
DB02546	Vorinostat	Small Molecule Drug
DB05223	SB939	Small Molecule Drug
DB06176	Romidepsin	Small Molecule Drug
DB05015	Belinostat	Small Molecule Drug
DB06603	Panobinostat	Small Molecule Drug

Summary
Symbol	HDAC6
Name	histone deacetylase 6
Aliases	KIAA0901; JM21; FLJ16239; PPP1R90; protein phosphatase 1, regulatory subunit 90; CPBHM
Location	Xp11.23
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Protein-Protein Interaction Network > miRNA Regulatory Relationship > Interactions from Text Mining

> Protein-Protein Interaction Network [ TOP ]

> miRNA Regulatory Relationship [ TOP ]

> Interactions from Text Mining [ TOP ]
There is no record for HDAC6.