CR2Cancer

Summary
Symbol	JARID2
Name	jumonji and AT-rich interaction domain containing 2
Aliases	JMJ; jumonji (mouse) homolog; jumonji homolog; jumonji-like protein; jumonji/ARID domain-containing protein ......
Location	6p22.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Domain, Function and Classification > Gene Ontology > KEGG and Reactome Pathway

> Domain, Function and Classification

[ TOP ]

Domain

PF01388 ARID/BRIGHT DNA binding domain
PF02373 JmjC domain
PF02375 jmjN domain
PF02928 C5HC2 zinc finger

Function

Regulator of histone methyltransferase complexes that plays an essential role in embryonic development, including heart and liver development, neural tube fusion process and hematopoiesis. Acts by modulating histone methyltransferase activity and promoting the recruitment of histone methyltransferase complexes to their target genes. Binds DNA and mediates the recruitment of the PRC2 complex to target genes in embryonic stem cells. Does not have histone demethylase activity but regulates activity of various histone methyltransferase complexes. In embryonic stem cells, it associates with the PRC2 complex and inhibits trimethylation of 'Lys-27' of histone H3 (H3K27me3) by the PRC2 complex, thereby playing a key role in differentiation of embryonic stem cells and normal development. In cardiac cells, it is required to repress expression of cyclin-D1 (CCND1) by activating methylation of 'Lys-9' of histone H3 (H3K9me) by the GLP1/EHMT1 and G9a/EHMT2 histone methyltransferases. Also acts as a transcriptional repressor of ANF via its interaction with GATA4 and NKX2-5. Participates in the negative regulation of cell proliferation signaling.

Classification

Class	Modification	Substrate	Product	PubMed
Histone modification write cofactor	Histone methylation	H3K27, H3K9	#	20075857

> Gene Ontology [ TOP ]
Biological Process	GO:0001889 liver development GO:0006479 protein methylation GO:0008213 protein alkylation GO:0016570 histone modification GO:0016571 histone methylation GO:0018022 peptidyl-lysine methylation GO:0018205 peptidyl-lysine modification GO:0031056 regulation of histone modification GO:0031057 negative regulation of histone modification GO:0031058 positive regulation of histone modification GO:0031060 regulation of histone methylation GO:0031061 negative regulation of histone methylation GO:0031062 positive regulation of histone methylation GO:0032259 methylation GO:0034968 histone lysine methylation GO:0040029 regulation of gene expression, epigenetic GO:0043414 macromolecule methylation GO:0045814 negative regulation of gene expression, epigenetic GO:0048536 spleen development GO:0048538 thymus development GO:0048732 gland development GO:0048863 stem cell differentiation GO:0051567 histone H3-K9 methylation GO:0051570 regulation of histone H3-K9 methylation GO:0051574 positive regulation of histone H3-K9 methylation GO:0061008 hepaticobiliary system development GO:0061647 histone H3-K9 modification GO:1902275 regulation of chromatin organization GO:1905268 negative regulation of chromatin organization GO:1905269 positive regulation of chromatin organization
Molecular Function	GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding GO:0003682 chromatin binding
Cellular Component	GO:0031519 PcG protein complex GO:0034708 methyltransferase complex GO:0035097 histone methyltransferase complex GO:0035098 ESC/E(Z) complex

> KEGG and Reactome Pathway [ TOP ]
KEGG	hsa04550 Signaling pathways regulating pluripotency of stem cells
Reactome	R-HSA-212165: Epigenetic regulation of gene expression R-HSA-74160: Gene Expression R-HSA-212300: PRC2 methylates histones and DNA

Summary
Symbol	JARID2
Name	jumonji and AT-rich interaction domain containing 2
Aliases	JMJ; jumonji (mouse) homolog; jumonji homolog; jumonji-like protein; jumonji/ARID domain-containing protein ......
Location	6p22.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Mutation landscape in primary tumor tissue from TCGA > Mutation landscape in cancer cell line from CCLE > All mutations from COSMIC database V81 > Variations from text mining

> The Cancer Genome Atlas (TCGA) [ TOP ]

> Cancer Cell Line Encyclopedia (CCLE) [ TOP ]

> Catalogue of Somatic Mutations in Cancer (COSMIC)

[ TOP ]

COSMIC ID	CDS change	AA change	Mutation Type	Anatomical Site
COSM3859826	c.1349C>T	p.A450V	Substitution - Missense	Bone
COSM3021850	c.2479C>T	p.R827*	Substitution - Nonsense	Large_intestine
COSM4543021	c.3301G>A	p.E1101K	Substitution - Missense	Skin
COSM1672248	c.114G>T	p.K38N	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM1211251	c.1412G>A	p.G471D	Substitution - Missense	Large_intestine
COSM5357670	c.1187C>T	p.A396V	Substitution - Missense	Large_intestine
COSM339871	c.815C>T	p.A272V	Substitution - Missense	Lung
COSM4930489	c.1381A>G	p.K461E	Substitution - Missense	Liver
COSM261476	c.2069C>A	p.A690D	Substitution - Missense	Large_intestine
COSM1441797	c.2289C>T	p.G763G	Substitution - coding silent	Large_intestine
COSM1239175	c.1266delG	p.R425fs*36	Deletion - Frameshift	Large_intestine
COSM295915	c.1029G>A	p.T343T	Substitution - coding silent	Large_intestine
COSM450756	c.71C>T	p.S24L	Substitution - Missense	Breast
COSM3859851	c.3007C>A	p.Q1003K	Substitution - Missense	Stomach
COSM240277	c.2148C>G	p.H716Q	Substitution - Missense	Prostate
COSM3859852	c.3025G>A	p.V1009I	Substitution - Missense	Stomach
COSM5510127	c.931C>T	p.R311*	Substitution - Nonsense	Biliary_tract
COSM450779	c.3279G>A	p.L1093L	Substitution - coding silent	Large_intestine
COSM1197648	c.1649G>T	p.G550V	Substitution - Missense	Lung
COSM4544673	c.3613G>C	p.G1205R	Substitution - Missense	Skin
COSM461866	c.1509G>A	p.T503T	Substitution - coding silent	Large_intestine
COSM4787782	c.1844A>G	p.H615R	Substitution - Missense	Liver
COSM1075259	c.3006G>A	p.Q1002Q	Substitution - coding silent	Endometrium
COSM461866	c.1509G>A	p.T503T	Substitution - coding silent	Cervix
COSM450777	c.1100C>G	p.P367R	Substitution - Missense	Breast
COSM4160310	c.1426G>T	p.A476S	Substitution - Missense	Thyroid
COSM3413904	c.3548G>A	p.R1183H	Substitution - Missense	Oesophagus
COSM150056	c.3205G>A	p.E1069K	Substitution - Missense	Stomach
COSM1075250	c.2262C>T	p.F754F	Substitution - coding silent	Endometrium
COSM3622182	c.2866G>A	p.E956K	Substitution - Missense	Skin
COSM4847368	c.2592C>G	p.H864Q	Substitution - Missense	Cervix
COSM3021833	c.1806C>T	p.N602N	Substitution - coding silent	Large_intestine
COSM4625710	c.3120C>T	p.G1040G	Substitution - coding silent	Large_intestine
COSM240275	c.651delA	p.K217fs*90	Deletion - Frameshift	Prostate
COSM1075243	c.736G>A	p.A246T	Substitution - Missense	Endometrium
COSM1211252	c.2197C>T	p.R733C	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM4979623	c.1020C>T	p.A340A	Substitution - coding silent	Oesophagus
COSM483595	c.1155A>T	p.K385N	Substitution - Missense	Kidney
COSM1239175	c.1266delG	p.R425fs*36	Deletion - Frameshift	Large_intestine
COSM3622176	c.1607C>T	p.P536L	Substitution - Missense	Skin
COSM1441794	c.1732C>T	p.R578C	Substitution - Missense	Large_intestine
COSM3366352	c.3401C>A	p.T1134K	Substitution - Missense	Kidney
COSM3622179	c.2431C>T	p.H811Y	Substitution - Missense	Skin
COSM1672249	c.1577C>G	p.S526C	Substitution - Missense	Large_intestine
COSM1239175	c.1266delG	p.R425fs*36	Deletion - Frameshift	Large_intestine
COSM5480496	c.1508C>T	p.T503M	Substitution - Missense	Large_intestine
COSM5591419	c.1544G>A	p.G515D	Substitution - Missense	Skin
COSM1672250	c.2960C>T	p.P987L	Substitution - Missense	Large_intestine
COSM4149223	c.2613C>A	p.N871K	Substitution - Missense	Ovary
COSM1634587	c.2275G>T	p.G759W	Substitution - Missense	Liver
COSM5702071	c.633_634GA>TT	p.R211_K212>S*	Complex - compound substitution	Soft_tissue
COSM1075261	c.3059G>A	p.C1020Y	Substitution - Missense	Endometrium
COSM740316	c.3505G>C	p.V1169L	Substitution - Missense	Lung
COSM4839522	c.3483T>C	p.C1161C	Substitution - coding silent	Cervix
COSM4551834	c.541G>A	p.D181N	Substitution - Missense	Skin
COSM1696939	c.3382A>G	p.K1128E	Substitution - Missense	Skin
COSM1441795	c.1770delC	p.P592fs*57	Deletion - Frameshift	Large_intestine
COSM5591417	c.1702C>T	p.H568Y	Substitution - Missense	Skin
COSM1075247	c.1727C>T	p.S576L	Substitution - Missense	Stomach
COSM3622184	c.3240C>T	p.T1080T	Substitution - coding silent	Skin
COSM3021600	c.89G>T	p.R30L	Substitution - Missense	Liver
COSM1211252	c.2197C>T	p.R733C	Substitution - Missense	Stomach
COSM5816119	c.1305G>A	p.E435E	Substitution - coding silent	Liver
COSM3021831	c.1730T>A	p.V577D	Substitution - Missense	Large_intestine
COSM4693805	c.2050C>A	p.L684M	Substitution - Missense	Large_intestine
COSM4693803	c.1752C>T	p.F584F	Substitution - coding silent	Large_intestine
COSM5649801	c.160G>A	p.G54R	Substitution - Missense	Oesophagus
COSM396178	c.3249C>G	p.A1083A	Substitution - coding silent	Lung
COSM181638	c.1786C>T	p.R596W	Substitution - Missense	Large_intestine
COSM3761611	c.1206C>T	p.P402P	Substitution - coding silent	Bone
COSM3859842	c.2206C>A	p.P736T	Substitution - Missense	Stomach
COSM3021763	c.643A>C	p.T215P	Substitution - Missense	Large_intestine
COSM3662251	c.1307G>A	p.G436E	Substitution - Missense	Liver
COSM337977	c.2263G>T	p.E755*	Substitution - Nonsense	Lung
COSM3761611	c.1206C>T	p.P402P	Substitution - coding silent	Large_intestine
COSM4613671	c.1365_1366insC	p.K458fs*66	Insertion - Frameshift	Large_intestine
COSM3021763	c.643A>C	p.T215P	Substitution - Missense	Large_intestine
COSM1075287	c.3661C>T	p.R1221C	Substitution - Missense	Endometrium
COSM1672249	c.1577C>G	p.S526C	Substitution - Missense	Large_intestine
COSM4592311	c.2084C>G	p.A695G	Substitution - Missense	Upper_aerodigestive_tract
COSM4832424	c.380C>T	p.T127I	Substitution - Missense	Cervix
COSM1441795	c.1770delC	p.P592fs*57	Deletion - Frameshift	Large_intestine
COSM4693796	c.505C>T	p.L169L	Substitution - coding silent	Large_intestine
COSM3622174	c.1429G>A	p.E477K	Substitution - Missense	Skin
COSM1672249	c.1577C>G	p.S526C	Substitution - Missense	Large_intestine
COSM5439004	c.972G>T	p.K324N	Substitution - Missense	Oesophagus
COSM4468782	c.1562C>T	p.S521F	Substitution - Missense	Skin
COSM4632390	c.1682G>T	p.R561M	Substitution - Missense	Large_intestine
COSM295915	c.1029G>A	p.T343T	Substitution - coding silent	Large_intestine
COSM3410720	c.3687C>T	p.P1229P	Substitution - coding silent	Central_nervous_system
COSM4787782	c.1844A>G	p.H615R	Substitution - Missense	Liver
COSM740315	c.3527G>A	p.R1176Q	Substitution - Missense	Lung
COSM1197180	c.1364C>T	p.S455L	Substitution - Missense	Soft_tissue
COSM3859828	c.1434A>G	p.R478R	Substitution - coding silent	Stomach
COSM5503074	c.1917C>A	p.G639G	Substitution - coding silent	Biliary_tract
COSM3715434	c.1655C>T	p.A552V	Substitution - Missense	Upper_aerodigestive_tract
COSM1211252	c.2197C>T	p.R733C	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM4479111	c.2297C>T	p.P766L	Substitution - Missense	Skin
COSM5061569	c.343A>G	p.R115G	Substitution - Missense	Stomach
COSM5357001	c.3607delA	p.N1204fs*>43	Deletion - Frameshift	Large_intestine
COSM4693807	c.2371G>A	p.A791T	Substitution - Missense	Large_intestine
COSM71233	c.2957C>A	p.S986Y	Substitution - Missense	Ovary
COSM3021837	c.1978C>T	p.R660W	Substitution - Missense	Large_intestine
COSM5749003	c.493+2T>A	p.?	Unknown	Pancreas
COSM4620481	c.3559G>C	p.E1187Q	Substitution - Missense	Large_intestine
COSM3829473	c.2718C>T	p.L906L	Substitution - coding silent	Stomach
COSM5045141	c.2914G>A	p.G972S	Substitution - Missense	Oesophagus
COSM1441800	c.3287G>A	p.R1096H	Substitution - Missense	Large_intestine
COSM4693799	c.1556G>T	p.S519I	Substitution - Missense	Large_intestine
COSM1211252	c.2197C>T	p.R733C	Substitution - Missense	Breast
COSM4586388	c.3465C>T	p.N1155N	Substitution - coding silent	Bone
COSM5404687	c.833C>T	p.S278F	Substitution - Missense	Skin
COSM5984104	c.3740G>A	p.1247	Substitution - coding silent	Upper_aerodigestive_tract
COSM1642923	c.412delC	p.P139fs*168	Deletion - Frameshift	Large_intestine
COSM3859830	c.1469C>T	p.P490L	Substitution - Missense	Stomach
COSM5357416	c.347A>C	p.K116T	Substitution - Missense	Large_intestine
COSM5455461	c.3552C>T	p.Y1184Y	Substitution - coding silent	Large_intestine
COSM4592311	c.2084C>G	p.A695G	Substitution - Missense	Upper_aerodigestive_tract
COSM4592311	c.2084C>G	p.A695G	Substitution - Missense	Upper_aerodigestive_tract
COSM3021743	c.466G>A	p.D156N	Substitution - Missense	Large_intestine
COSM4352288	c.3149G>A	p.R1050H	Substitution - Missense	Large_intestine
COSM4651568	c.3286C>T	p.R1096C	Substitution - Missense	Large_intestine
COSM740327	c.1179C>T	p.L393L	Substitution - coding silent	Lung
COSM4414674	c.2990T>C	p.V997A	Substitution - Missense	Kidney
COSM1255154	c.880C>T	p.R294W	Substitution - Missense	Oesophagus
COSM1166621	c.3005_3006insG	p.Q1003fs*25	Insertion - Frameshift	Haematopoietic_and_lymphoid_tissue
COSM3662251	c.1307G>A	p.G436E	Substitution - Missense	Liver
COSM740320	c.2952+2T>A	p.?	Unknown	Lung
COSM1211250	c.1160G>A	p.R387H	Substitution - Missense	Thyroid
COSM5452071	c.3039A>T	p.G1013G	Substitution - coding silent	Large_intestine
COSM4188560	c.348G>C	p.K116N	Substitution - Missense	Kidney
COSM4693812	c.3095C>T	p.A1032V	Substitution - Missense	Large_intestine
COSM483593	c.366G>T	p.P122P	Substitution - coding silent	Kidney
COSM4625708	c.2260T>A	p.F754I	Substitution - Missense	Large_intestine
COSM3859837	c.2077C>T	p.R693W	Substitution - Missense	Stomach
COSM1696938	c.1499A>C	p.K500T	Substitution - Missense	Skin
COSM5357001	c.3607delA	p.N1204fs*>43	Deletion - Frameshift	Large_intestine
COSM3829473	c.2718C>T	p.L906L	Substitution - coding silent	Breast
COSM177163	c.490C>T	p.R164*	Substitution - Nonsense	Skin
COSM3622173	c.1197C>T	p.S399S	Substitution - coding silent	Skin
COSM1672248	c.114G>T	p.K38N	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM5749003	c.493+2T>A	p.?	Unknown	Pancreas
COSM3622172	c.1175C>T	p.S392F	Substitution - Missense	Skin
COSM4933336	c.2708T>A	p.L903Q	Substitution - Missense	Liver
COSM1211250	c.1160G>A	p.R387H	Substitution - Missense	Large_intestine
COSM5695192	c.362A>G	p.Q121R	Substitution - Missense	Soft_tissue
COSM4693814	c.3592G>A	p.G1198S	Substitution - Missense	Large_intestine
COSM1197648	c.1649G>T	p.G550V	Substitution - Missense	Lung
COSM3715434	c.1655C>T	p.A552V	Substitution - Missense	Upper_aerodigestive_tract
COSM1239175	c.1266delG	p.R425fs*36	Deletion - Frameshift	Oesophagus
COSM5357428	c.465A>C	p.E155D	Substitution - Missense	Large_intestine
COSM5061576	c.3672G>A	p.A1224A	Substitution - coding silent	Stomach
COSM3702926	c.1037C>T	p.A346V	Substitution - Missense	Liver
COSM1441795	c.1770delC	p.P592fs*57	Deletion - Frameshift	Large_intestine
COSM5457234	c.1509G>T	p.T503T	Substitution - coding silent	Large_intestine
COSM3697623	c.3053A>T	p.K1018I	Substitution - Missense	Large_intestine
COSM5634385	c.1147A>C	p.N383H	Substitution - Missense	Oesophagus
COSM5357416	c.347A>C	p.K116T	Substitution - Missense	Large_intestine
COSM302445	c.581A>T	p.D194V	Substitution - Missense	Central_nervous_system
COSM3697624	c.3227C>G	p.P1076R	Substitution - Missense	Large_intestine
COSM1255157	c.3622G>A	p.E1208K	Substitution - Missense	Oesophagus
COSM1075268	c.3358G>A	p.A1120T	Substitution - Missense	Endometrium
COSM117387	c.1670T>G	p.I557S	Substitution - Missense	Ovary
COSM4646764	c.538C>A	p.Q180K	Substitution - Missense	Large_intestine
COSM1211249	c.1523C>T	p.T508M	Substitution - Missense	Large_intestine
COSM1239175	c.1266delG	p.R425fs*36	Deletion - Frameshift	Large_intestine
COSM5514515	c.520G>A	p.V174M	Substitution - Missense	Biliary_tract
COSM1642923	c.412delC	p.P139fs*168	Deletion - Frameshift	Stomach
COSM5894395	c.46-3C>T	p.?	Unknown	Skin
COSM1075258	c.2856T>C	p.I952I	Substitution - coding silent	Endometrium
COSM4149225	c.2961G>A	p.P987P	Substitution - coding silent	Ovary
COSM3622198	c.3466G>A	p.E1156K	Substitution - Missense	Skin
COSM79209	c.733G>T	p.E245*	Substitution - Nonsense	Ovary
COSM3697622	c.2947G>A	p.V983I	Substitution - Missense	Large_intestine
COSM1239176	c.2719G>A	p.G907S	Substitution - Missense	Oesophagus
COSM22855	c.2596G>A	p.G866S	Substitution - Missense	Pancreas
COSM450778	c.1274G>A	p.R425Q	Substitution - Missense	Breast
COSM1239175	c.1266delG	p.R425fs*36	Deletion - Frameshift	Large_intestine
COSM3021598	c.79C>T	p.R27W	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM1075248	c.1792G>A	p.E598K	Substitution - Missense	Endometrium
COSM4925052	c.2062A>G	p.R688G	Substitution - Missense	Liver
COSM4149226	c.3234C>A	p.L1078L	Substitution - coding silent	Ovary
COSM5888913	c.820C>T	p.P274S	Substitution - Missense	Skin
COSM740326	c.1389G>T	p.A463A	Substitution - coding silent	Lung
COSM4592311	c.2084C>G	p.A695G	Substitution - Missense	Upper_aerodigestive_tract
COSM3859792	c.197A>G	p.D66G	Substitution - Missense	Stomach
COSM1441791	c.1265_1266insG	p.R425fs*99	Insertion - Frameshift	Large_intestine
COSM240276	c.1164A>C	p.K388N	Substitution - Missense	Prostate
COSM4592311	c.2084C>G	p.A695G	Substitution - Missense	Upper_aerodigestive_tract
COSM1075248	c.1792G>A	p.E598K	Substitution - Missense	Endometrium
COSM3622185	c.3377C>T	p.P1126L	Substitution - Missense	Skin
COSM5011576	c.2763G>T	p.M921I	Substitution - Missense	Kidney
COSM1255155	c.3364G>A	p.G1122R	Substitution - Missense	Stomach
COSM4927628	c.586A>C	p.K196Q	Substitution - Missense	Liver
COSM4693811	c.3036G>A	p.P1012P	Substitution - coding silent	Large_intestine
COSM3021883	c.3112A>C	p.S1038R	Substitution - Missense	Large_intestine
COSM3859832	c.1470G>A	p.P490P	Substitution - coding silent	Stomach
COSM1737709	c.1069G>A	p.V357I	Substitution - Missense	Central_nervous_system
COSM345811	c.2543A>G	p.Q848R	Substitution - Missense	Lung
COSM5733936	c.782G>A	p.R261H	Substitution - Missense	Pancreas
COSM3920933	c.184C>T	p.L62F	Substitution - Missense	Skin
COSM3777256	c.2997G>C	p.R999S	Substitution - Missense	Urinary_tract
COSM3021854	c.2674C>A	p.L892I	Substitution - Missense	Large_intestine
COSM5650021	c.2669delG	p.W890fs*1	Deletion - Frameshift	Oesophagus
COSM5749003	c.493+2T>A	p.?	Unknown	Pancreas
COSM1211252	c.2197C>T	p.R733C	Substitution - Missense	Large_intestine
COSM450779	c.3279G>A	p.L1093L	Substitution - coding silent	Large_intestine
COSM5975860	c.363G>A	p.Q121Q	Substitution - coding silent	Upper_aerodigestive_tract
COSM1239177	c.3704C>T	p.A1235V	Substitution - Missense	Oesophagus
COSM4899571	c.2743C>T	p.P915S	Substitution - Missense	Skin
COSM4693813	c.3221A>G	p.N1074S	Substitution - Missense	Large_intestine
COSM1672250	c.2960C>T	p.P987L	Substitution - Missense	Large_intestine
COSM4693793	c.323+2T>C	p.?	Unknown	Large_intestine
COSM4609625	c.3564G>C	p.Q1188H	Substitution - Missense	Adrenal_gland
COSM4982546	c.54T>C	p.S18S	Substitution - coding silent	Oesophagus
COSM740325	c.1502G>A	p.R501Q	Substitution - Missense	Lung
COSM3021829	c.1651T>C	p.W551R	Substitution - Missense	Oesophagus
COSM4750312	c.3135G>T	p.K1045N	Substitution - Missense	Stomach
COSM3622136	c.56A>T	p.D19V	Substitution - Missense	Skin
COSM325575	c.2166G>T	p.E722D	Substitution - Missense	Lung
COSM4823939	c.1402G>A	p.E468K	Substitution - Missense	Cervix
COSM1075254	c.2768T>C	p.F923S	Substitution - Missense	Endometrium
COSM5357428	c.465A>C	p.E155D	Substitution - Missense	Large_intestine
COSM269405	c.2993A>G	p.H998R	Substitution - Missense	Large_intestine
COSM1075250	c.2262C>T	p.F754F	Substitution - coding silent	Endometrium
COSM240274	c.491G>A	p.R164Q	Substitution - Missense	Prostate
COSM594892	c.1487G>A	p.R496K	Substitution - Missense	Skin
COSM1075249	c.2091G>A	p.L697L	Substitution - coding silent	Endometrium
COSM3859853	c.3084C>T	p.T1028T	Substitution - coding silent	Stomach
COSM4586386	c.1301G>A	p.R434Q	Substitution - Missense	Bone
COSM1311738	c.1250C>T	p.S417L	Substitution - Missense	Urinary_tract
COSM3622177	c.1778C>T	p.P593L	Substitution - Missense	Skin
COSM5965360	c.822C>A	p.P274P	Substitution - coding silent	Breast
COSM1239175	c.1266delG	p.R425fs*36	Deletion - Frameshift	Large_intestine
COSM3021797	c.698G>A	p.R233Q	Substitution - Missense	Skin
COSM4850307	c.550G>A	p.E184K	Substitution - Missense	Cervix
COSM1075190	c.141G>T	p.Q47H	Substitution - Missense	Endometrium
COSM1075253	c.2664T>C	p.H888H	Substitution - coding silent	Endometrium
COSM3622171	c.1075G>C	p.D359H	Substitution - Missense	Skin
COSM4693801	c.1635C>T	p.G545G	Substitution - coding silent	Large_intestine
COSM4693809	c.2637A>G	p.V879V	Substitution - coding silent	Large_intestine
COSM1441790	c.1188G>A	p.A396A	Substitution - coding silent	Large_intestine
COSM5635674	c.1292T>G	p.L431R	Substitution - Missense	Oesophagus
COSM1211250	c.1160G>A	p.R387H	Substitution - Missense	Large_intestine
COSM3622178	c.2295C>T	p.A765A	Substitution - coding silent	Skin
COSM3622170	c.743C>T	p.P248L	Substitution - Missense	Skin
COSM1075287	c.3661C>T	p.R1221C	Substitution - Missense	Large_intestine
COSM3920932	c.128C>T	p.S43F	Substitution - Missense	Skin
COSM5749003	c.493+2T>A	p.?	Unknown	Pancreas
COSM1239175	c.1266delG	p.R425fs*36	Deletion - Frameshift	Prostate
COSM5901437	c.923G>A	p.G308E	Substitution - Missense	Skin
COSM28336	c.1617G>A	p.S539S	Substitution - coding silent	Lung
COSM3859835	c.1856G>A	p.R619Q	Substitution - Missense	Stomach
COSM4639192	c.1348G>A	p.A450T	Substitution - Missense	Large_intestine
COSM300189	c.837G>A	p.S279S	Substitution - coding silent	Large_intestine
COSM1075252	c.2657C>T	p.S886L	Substitution - Missense	Endometrium
COSM1236450	c.246G>T	p.K82N	Substitution - Missense	Autonomic_ganglia
COSM3374104	c.3321C>T	p.S1107S	Substitution - coding silent	Thyroid
COSM3859822	c.1037C>A	p.A346D	Substitution - Missense	Stomach
COSM3410719	c.2524G>T	p.A842S	Substitution - Missense	Central_nervous_system
COSM4470200	c.1647C>T	p.A549A	Substitution - coding silent	Skin
COSM3920950	c.1772C>T	p.P591L	Substitution - Missense	Skin
COSM1672249	c.1577C>G	p.S526C	Substitution - Missense	Large_intestine
COSM3697621	c.1665C>T	p.D555D	Substitution - coding silent	Large_intestine
COSM1211254	c.497C>A	p.S166Y	Substitution - Missense	Large_intestine
COSM269404	c.2020C>T	p.L674F	Substitution - Missense	Large_intestine
COSM4839643	c.2873A>G	p.N958S	Substitution - Missense	Cervix
COSM1075260	c.3041C>T	p.S1014F	Substitution - Missense	Endometrium
COSM4592311	c.2084C>G	p.A695G	Substitution - Missense	Upper_aerodigestive_tract
COSM3859826	c.1349C>T	p.A450V	Substitution - Missense	Stomach
COSM3859854	c.3172A>G	p.M1058V	Substitution - Missense	Stomach
COSM373211	c.209G>T	p.G70V	Substitution - Missense	Lung
COSM5510125	c.664G>A	p.G222R	Substitution - Missense	Biliary_tract
COSM1239175	c.1266delG	p.R425fs*36	Deletion - Frameshift	Oesophagus
COSM1075252	c.2657C>T	p.S886L	Substitution - Missense	Endometrium
COSM4993837	c.39G>T	p.K13N	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM1075246	c.1557C>T	p.S519S	Substitution - coding silent	Endometrium
COSM3859824	c.1299G>T	p.L433L	Substitution - coding silent	Stomach
COSM3021820	c.1388C>T	p.A463V	Substitution - Missense	Large_intestine
COSM1239175	c.1266delG	p.R425fs*36	Deletion - Frameshift	Prostate
COSM4961954	c.522G>A	p.V174V	Substitution - coding silent	Pancreas
COSM3622175	c.1492C>T	p.R498W	Substitution - Missense	Skin
COSM1211253	c.146C>T	p.A49V	Substitution - Missense	Large_intestine
COSM1075191	c.147G>A	p.A49A	Substitution - coding silent	Endometrium
COSM5619414	c.597C>G	p.T199T	Substitution - coding silent	Breast
COSM1441792	c.1497G>A	p.P499P	Substitution - coding silent	Large_intestine
COSM4592311	c.2084C>G	p.A695G	Substitution - Missense	Upper_aerodigestive_tract
COSM3622183	c.2881G>A	p.E961K	Substitution - Missense	Skin
COSM1239175	c.1266delG	p.R425fs*36	Deletion - Frameshift	Large_intestine
COSM4922419	c.574A>T	p.T192S	Substitution - Missense	Liver
COSM740322	c.2634A>C	p.P878P	Substitution - coding silent	Lung
COSM177163	c.490C>T	p.R164*	Substitution - Nonsense	Endometrium
COSM1075247	c.1727C>T	p.S576L	Substitution - Missense	Endometrium
COSM1075238	c.515G>T	p.S172I	Substitution - Missense	Endometrium
COSM1255156	c.1456A>T	p.K486*	Substitution - Nonsense	Stomach
COSM1075239	c.553G>T	p.V185F	Substitution - Missense	Endometrium
COSM1239175	c.1266delG	p.R425fs*36	Deletion - Frameshift	Large_intestine
COSM1255154	c.880C>T	p.R294W	Substitution - Missense	Pancreas
COSM4460695	c.1176C>T	p.S392S	Substitution - coding silent	Skin
COSM4941156	c.443C>G	p.S148C	Substitution - Missense	Liver
COSM1441796	c.2022_2023insA	p.W677fs*133	Insertion - Frameshift	Haematopoietic_and_lymphoid_tissue
COSM1075245	c.1158C>G	p.T386T	Substitution - coding silent	Endometrium
COSM1197180	c.1364C>T	p.S455L	Substitution - Missense	Lung
COSM3021602	c.231G>T	p.Q77H	Substitution - Missense	Large_intestine
COSM4643066	c.3500G>A	p.R1167H	Substitution - Missense	Large_intestine
COSM740323	c.2078G>A	p.R693Q	Substitution - Missense	Lung
COSM5789205	c.1941C>T	p.L647L	Substitution - coding silent	Breast
COSM213224	c.1858C>T	p.R620C	Substitution - Missense	Breast
COSM4693791	c.314C>T	p.S105L	Substitution - Missense	Large_intestine
COSM3622168	c.628C>A	p.P210T	Substitution - Missense	Skin
COSM4539235	c.2660G>A	p.R887K	Substitution - Missense	Skin
COSM1239175	c.1266delG	p.R425fs*36	Deletion - Frameshift	Prostate
COSM1441798	c.2399A>G	p.E800G	Substitution - Missense	Large_intestine
COSM5753171	c.2766C>G	p.V922V	Substitution - coding silent	Pancreas
COSM3777253	c.461C>T	p.T154I	Substitution - Missense	Urinary_tract
COSM5491999	c.2594G>A	p.C865Y	Substitution - Missense	Biliary_tract
COSM290061	c.2507G>C	p.C836S	Substitution - Missense	Large_intestine
COSM3777254	c.608C>T	p.S203L	Substitution - Missense	Urinary_tract
COSM3859839	c.2110T>C	p.Y704H	Substitution - Missense	Stomach
COSM5712353	c.85G>C	p.V29L	Substitution - Missense	Central_nervous_system
COSM3859866	c.3688C>T	p.P1230S	Substitution - Missense	Stomach
COSM1672250	c.2960C>T	p.P987L	Substitution - Missense	Large_intestine
COSM4643066	c.3500G>A	p.R1167H	Substitution - Missense	Large_intestine
COSM1075244	c.1147A>G	p.N383D	Substitution - Missense	Endometrium
COSM4921637	c.1842C>T	p.I614I	Substitution - coding silent	Liver
COSM4902453	c.2188C>T	p.L730L	Substitution - coding silent	Skin
COSM5433187	c.1842C>G	p.I614M	Substitution - Missense	Oesophagus
COSM5490840	c.3472G>A	p.V1158I	Substitution - Missense	Biliary_tract
COSM3859865	c.3591C>T	p.C1197C	Substitution - coding silent	Stomach
COSM3859867	c.3733T>C	p.S1245P	Substitution - Missense	Stomach
COSM1696937	c.148G>A	p.E50K	Substitution - Missense	Skin
COSM4628496	c.2111A>G	p.Y704C	Substitution - Missense	Large_intestine
COSM1075251	c.2621G>A	p.G874D	Substitution - Missense	Endometrium
COSM1211248	c.2258G>A	p.R753H	Substitution - Missense	Large_intestine
COSM245105	c.2448+1G>C	p.?	Unknown	Prostate
COSM5431594	c.2789G>C	p.R930P	Substitution - Missense	Oesophagus

> Text Mining based Variations [ TOP ]
There is no record for JARID2.

Summary
Symbol	JARID2
Name	jumonji and AT-rich interaction domain containing 2
Aliases	JMJ; jumonji (mouse) homolog; jumonji homolog; jumonji-like protein; jumonji/ARID domain-containing protein ......
Location	6p22.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Post-translational modification (PTM)

> Post-translational modification (PTM)

[ TOP ]

Filter By:

Uniprot ID	Position	Amino Acid	Description	Upstream Enzyme	Affected By Mutation	Amino Acid Sequence Variant
Q92833	378	K	N6-acetyllysine	-	No	None detected
Q92833	455	S	Phosphoserine	-	No	None detected

Summary
Symbol	JARID2
Name	jumonji and AT-rich interaction domain containing 2
Aliases	JMJ; jumonji (mouse) homolog; jumonji homolog; jumonji-like protein; jumonji/ARID domain-containing protein ......
Location	6p22.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Expression analysis in primary tumor tissue from TCGA > Expression level in cancer cell line from CCLE > Expression level in human normal tissue from HPA > Text mining based expression change

> The Cancer Genome Atlas (TCGA)

[ TOP ]

Differential expression analysis for cancers with more than 10 normal samples

Cancer	Full Name	# N	# T	Median (N)	Median (T)	LogFC	Adj. P	Status
BLCA	Bladder urothelial carcinoma	19	408	4.535	5.146	0.459	0.0418	NS
BRCA	Breast invasive carcinoma	112	1100	4.765	5.336	0.604	9.61e-23	Over
CESC	Cervical and endocervical cancers	3	306	4.212	5.097	NA	NA	NA
COAD	Colon adenocarcinoma	41	459	4.467	4.635	0.225	0.0179	NS
ESCA	Esophageal carcinoma	11	185	4.661	5.545	0.477	0.155	NS
GBM	Glioblastoma multiforme	5	166	5.142	4.51	NA	NA	NA
HNSC	Head and Neck squamous cell carcinoma	44	522	5.605	5.879	0.37	0.00122	NS
KIRC	Kidney renal clear cell carcinoma	72	534	3.844	4.351	0.391	2.69e-11	NS
KIRP	Kidney renal papillary cell carcinoma	32	291	3.884	3.753	-0.15	0.114	NS
LAML	Acute Myeloid Leukemia	0	173	NA	7.58	NA	NA	NA
LGG	Brain Lower Grade Glioma	0	530	NA	5.25	NA	NA	NA
LIHC	Liver hepatocellular carcinoma	50	373	2.987	3.322	0.391	6.01e-05	NS
LUAD	Lung adenocarcinoma	59	517	4.522	4.618	0.195	0.0324	NS
LUSC	Lung squamous cell carcinoma	51	501	4.464	5.651	1.189	1.25e-28	Over
OV	Ovarian serous cystadenocarcinoma	0	307	NA	4.741	NA	NA	NA
PAAD	Pancreatic adenocarcinoma	4	179	4.92	4.345	NA	NA	NA
PCPG	Pheochromocytoma and Paraganglioma	3	184	3.932	4.026	NA	NA	NA
PRAD	Prostate adenocarcinoma	52	498	4.261	4.509	0.264	0.000165	NS
READ	Rectum adenocarcinoma	10	167	4.298	4.809	0.604	0.0015	Over
SARC	Sarcoma	2	263	3.546	4.051	NA	NA	NA
SKCM	Skin Cutaneous Melanoma	1	472	6.103	6.144	NA	NA	NA
STAD	Stomach adenocarcinoma	35	415	5.015	4.896	-0.242	0.0445	NS
TGCT	Testicular Germ Cell Tumors	0	156	NA	7.101	NA	NA	NA
THCA	Thyroid carcinoma	59	509	3.986	3.938	-0.037	0.535	NS
THYM	Thymoma	2	120	6.354	5.556	NA	NA	NA
UCEC	Uterine Corpus Endometrial Carcinoma	35	546	4.262	4.939	0.624	4.31e-10	Over

> Cancer Cell Line Encyclopedia (CCLE)

[ TOP ]

Tissue	Cell Line	Expression Level (Microarray)
Autonomic ganglia	CHP126	9.4
Autonomic ganglia	CHP212	6.9
Autonomic ganglia	IMR32	9.5
Autonomic ganglia	KELLY	8.8
Autonomic ganglia	KPNRTBM1	8.6
Autonomic ganglia	KPNSI9S	7.3
Autonomic ganglia	KPNYN	8.5
Autonomic ganglia	MHHNB11	7.9
Autonomic ganglia	NB1	9.3
Autonomic ganglia	NH6	8
Autonomic ganglia	SHSY5Y	7.9
Autonomic ganglia	SIMA	9.2
Autonomic ganglia	SKNAS	7.9
Autonomic ganglia	SKNBE2	8.8
Autonomic ganglia	SKNDZ	9.3
Autonomic ganglia	SKNFI	8.1
Autonomic ganglia	SKNSH	6.7
Biliary tract	HUCCT1	7.8
Biliary tract	HUH28	7.8
Biliary tract	SNU1079	7.5
Biliary tract	SNU1196	6.4
Biliary tract	SNU245	7
Biliary tract	SNU308	7
Biliary tract	SNU478	7.4
Bone	143B	6.9
Bone	A673	8.5
Bone	CADOES1	9.7
Bone	CAL78	7.8
Bone	G292CLONEA141B1	6.9
Bone	HOS	7.7
Bone	HS706T	6.7
Bone	HS737T	6.9
Bone	HS819T	6.5
Bone	HS821T	7
Bone	HS822T	6.6
Bone	HS863T	6.8
Bone	HS870T	6.7
Bone	HS888T	7.1
Bone	MG63	5.2
Bone	MHHES1	9.3
Bone	OUMS27	7
Bone	RDES	9.1
Bone	SJSA1	7
Bone	SKES1	8.8
Bone	SKNMC	9.9
Bone	SW1353	8.7
Bone	T173	6.2
Bone	TC71	8.6
Bone	U2OS	7.9
Breast	AU565	8.7
Breast	BT20	8.1
Breast	BT474	7.9
Breast	BT483	8.8
Breast	BT549	7.3
Breast	CAL120	8.8
Breast	CAL148	8.4
Breast	CAL51	8.1
Breast	CAL851	8.1
Breast	CAMA1	8.4
Breast	DU4475	7.4
Breast	EFM192A	8.1
Breast	EFM19	9.3
Breast	EVSAT	8
Breast	HCC1143	7.7
Breast	HCC1187	8.3
Breast	HCC1395	8.3
Breast	HCC1419	8.8
Breast	HCC1428	8.5
Breast	HCC1500	7.7
Breast	HCC1569	7.5
Breast	HCC1599	7.3
Breast	HCC1806	9.5
Breast	HCC1937	7.9
Breast	HCC1954	8
Breast	HCC202	7.7
Breast	HCC2157	7.7
Breast	HCC2218	8
Breast	HCC38	7.3
Breast	HCC70	7
Breast	HDQP1	8.5
Breast	HMC18	6.9
Breast	HS274T	7
Breast	HS281T	6.3
Breast	HS343T	6.9
Breast	HS578T	8.7
Breast	HS606T	6.9
Breast	HS739T	6.3
Breast	HS742T	7.2
Breast	JIMT1	8.1
Breast	KPL1	8.2
Breast	MCF7	8.8
Breast	MDAMB134VI	7.5
Breast	MDAMB157	7
Breast	MDAMB175VII	7.8
Breast	MDAMB231	8.6
Breast	MDAMB361	7.6
Breast	MDAMB415	7.1
Breast	MDAMB436	6.3
Breast	MDAMB453	7.8
Breast	MDAMB468	8.1
Breast	SKBR3	8.4
Breast	T47D	7.2
Breast	UACC812	9.3
Breast	UACC893	8.9
Breast	YMB1	7.8
Breast	ZR751	7.4
Breast	ZR7530	8.4
Central nervous system	1321N1	6.4
Central nervous system	42MGBA	7.3
Central nervous system	8MGBA	7.3
Central nervous system	A172	6.8
Central nervous system	AM38	7.1
Central nervous system	BECKER	7.1
Central nervous system	CAS1	7.1
Central nervous system	CCFSTTG1	6.2
Central nervous system	D283MED	7.6
Central nervous system	D341MED	8.9
Central nervous system	DAOY	8
Central nervous system	DBTRG05MG	6.4
Central nervous system	DKMG	7
Central nervous system	GAMG	7.6
Central nervous system	GB1	7.2
Central nervous system	GI1	7.2
Central nervous system	GMS10	8.2
Central nervous system	GOS3	6.4
Central nervous system	H4	7.7
Central nervous system	HS683	6.7
Central nervous system	KALS1	7.8
Central nervous system	KG1C	7.1
Central nervous system	KNS42	6.8
Central nervous system	KNS60	7.4
Central nervous system	KNS81	6.7
Central nervous system	KS1	6.5
Central nervous system	LN18	7.7
Central nervous system	LN229	7.1
Central nervous system	M059K	6.5
Central nervous system	MOGGCCM	6.3
Central nervous system	MOGGUVW	6.7
Central nervous system	NMCG1	6.9
Central nervous system	ONS76	7.7
Central nervous system	SF126	7.1
Central nervous system	SF295	7.1
Central nervous system	SNB19	7.3
Central nervous system	SNU1105	8.6
Central nervous system	SNU201	7
Central nervous system	SNU466	7.2
Central nervous system	SNU489	8.6
Central nervous system	SNU626	6.5
Central nervous system	SNU738	7.5
Central nervous system	SW1088	7.8
Central nervous system	SW1783	6.9
Central nervous system	T98G	7.7
Central nervous system	TM31	8.7
Central nervous system	U118MG	7.6
Central nervous system	U138MG	8.1
Central nervous system	U251MG	8.8
Central nervous system	U87MG	6.7
Central nervous system	YH13	7.6
Central nervous system	YKG1	7.2
Endometrium	AN3CA	7.4
Endometrium	COLO684	7.6
Endometrium	EFE184	7.6
Endometrium	EN	6.7
Endometrium	ESS1	7
Endometrium	HEC108	7.2
Endometrium	HEC151	7
Endometrium	HEC1A	6.4
Endometrium	HEC1B	6.4
Endometrium	HEC251	6.7
Endometrium	HEC265	7.3
Endometrium	HEC50B	6.2
Endometrium	HEC59	8.8
Endometrium	HEC6	6.9
Endometrium	ISHIKAWAHERAKLIO02ER	6.5
Endometrium	JHUEM1	7
Endometrium	JHUEM2	8.7
Endometrium	JHUEM3	7.6
Endometrium	KLE	6.4
Endometrium	MFE280	7.7
Endometrium	MFE296	5.8
Endometrium	MFE319	7.4
Endometrium	RL952	7.8
Endometrium	SNGM	7.7
Endometrium	SNU1077	8
Endometrium	SNU685	8.7
Endometrium	TEN	6.8
Haematopoietic and lymphoid	697	9.5
Haematopoietic and lymphoid	A3KAW	8.9
Haematopoietic and lymphoid	A4FUK	7.9
Haematopoietic and lymphoid	ALLSIL	9.7
Haematopoietic and lymphoid	AML193	10.5
Haematopoietic and lymphoid	AMO1	7.2
Haematopoietic and lymphoid	BCP1	6.8
Haematopoietic and lymphoid	BDCM	7.7
Haematopoietic and lymphoid	BL41	7.3
Haematopoietic and lymphoid	BL70	6.8
Haematopoietic and lymphoid	BV173	9
Haematopoietic and lymphoid	CA46	8.6
Haematopoietic and lymphoid	CI1	7.1
Haematopoietic and lymphoid	CMK115	9.4
Haematopoietic and lymphoid	CMK86	9.6
Haematopoietic and lymphoid	CMK	9.5
Haematopoietic and lymphoid	CMLT1	11.1
Haematopoietic and lymphoid	COLO775	8.3
Haematopoietic and lymphoid	DAUDI	7.4
Haematopoietic and lymphoid	DB	6
Haematopoietic and lymphoid	DEL	8.1
Haematopoietic and lymphoid	DND41	8.5
Haematopoietic and lymphoid	DOHH2	7.5
Haematopoietic and lymphoid	EB1	8.3
Haematopoietic and lymphoid	EB2	7.4
Haematopoietic and lymphoid	EHEB	6.2
Haematopoietic and lymphoid	EJM	7.9
Haematopoietic and lymphoid	EM2	9.9
Haematopoietic and lymphoid	EOL1	9
Haematopoietic and lymphoid	F36P	8.4
Haematopoietic and lymphoid	GA10	8
Haematopoietic and lymphoid	GDM1	9.6
Haematopoietic and lymphoid	GRANTA519	8.6
Haematopoietic and lymphoid	HDLM2	8.3
Haematopoietic and lymphoid	HDMYZ	7.6
Haematopoietic and lymphoid	HEL9217	8.7
Haematopoietic and lymphoid	HEL	8.4
Haematopoietic and lymphoid	HH	7.7
Haematopoietic and lymphoid	HL60	9.8
Haematopoietic and lymphoid	HPBALL	9.8
Haematopoietic and lymphoid	HS604T	7.9
Haematopoietic and lymphoid	HS611T	7.5
Haematopoietic and lymphoid	HS616T	7.1
Haematopoietic and lymphoid	HS751T	7
Haematopoietic and lymphoid	HT	6.7
Haematopoietic and lymphoid	HTK	7.8
Haematopoietic and lymphoid	HUNS1	7.5
Haematopoietic and lymphoid	HUT102	8.5
Haematopoietic and lymphoid	HUT78	9.5
Haematopoietic and lymphoid	JEKO1	8.9
Haematopoietic and lymphoid	JK1	10.5
Haematopoietic and lymphoid	JM1	8.9
Haematopoietic and lymphoid	JURKAT	10
Haematopoietic and lymphoid	JURLMK1	9.5
Haematopoietic and lymphoid	JVM2	4.4
Haematopoietic and lymphoid	JVM3	9.3
Haematopoietic and lymphoid	K562	8.6
Haematopoietic and lymphoid	KARPAS299	10.1
Haematopoietic and lymphoid	KARPAS422	6.5
Haematopoietic and lymphoid	KARPAS620	8.3
Haematopoietic and lymphoid	KASUMI1	9.3
Haematopoietic and lymphoid	KASUMI2	9.1
Haematopoietic and lymphoid	KASUMI6	10.4
Haematopoietic and lymphoid	KCL22	9.4
Haematopoietic and lymphoid	KE37	9.6
Haematopoietic and lymphoid	KE97	7.9
Haematopoietic and lymphoid	KG1	9.5
Haematopoietic and lymphoid	KHM1B	8.1
Haematopoietic and lymphoid	KIJK	8.3
Haematopoietic and lymphoid	KMH2	8.5
Haematopoietic and lymphoid	KMM1	7.1
Haematopoietic and lymphoid	KMS11	8
Haematopoietic and lymphoid	KMS12BM	8.5
Haematopoietic and lymphoid	KMS18	8.4
Haematopoietic and lymphoid	KMS20	7.7
Haematopoietic and lymphoid	KMS21BM	7.6
Haematopoietic and lymphoid	KMS26	7.7
Haematopoietic and lymphoid	KMS27	6.9
Haematopoietic and lymphoid	KMS28BM	7.3
Haematopoietic and lymphoid	KMS34	8
Haematopoietic and lymphoid	KO52	10.3
Haematopoietic and lymphoid	KOPN8	9.8
Haematopoietic and lymphoid	KU812	10.6
Haematopoietic and lymphoid	KYO1	9.3
Haematopoietic and lymphoid	L1236	7.3
Haematopoietic and lymphoid	L363	7.2
Haematopoietic and lymphoid	L428	7.4
Haematopoietic and lymphoid	L540	7.6
Haematopoietic and lymphoid	LAMA84	10.2
Haematopoietic and lymphoid	LOUCY	10.4
Haematopoietic and lymphoid	LP1	7.6
Haematopoietic and lymphoid	M07E	9.8
Haematopoietic and lymphoid	MC116	7.2
Haematopoietic and lymphoid	ME1	9.2
Haematopoietic and lymphoid	MEC1	8.2
Haematopoietic and lymphoid	MEC2	7.1
Haematopoietic and lymphoid	MEG01	9.6
Haematopoietic and lymphoid	MHHCALL2	9.2
Haematopoietic and lymphoid	MHHCALL3	9.5
Haematopoietic and lymphoid	MHHCALL4	8.7
Haematopoietic and lymphoid	MINO	7.5
Haematopoietic and lymphoid	MJ	7
Haematopoietic and lymphoid	MM1S	8.1
Haematopoietic and lymphoid	MOLM13	9.5
Haematopoietic and lymphoid	MOLM16	10.2
Haematopoietic and lymphoid	MOLM6	9.5
Haematopoietic and lymphoid	MOLP2	7.1
Haematopoietic and lymphoid	MOLP8	7.9
Haematopoietic and lymphoid	MOLT13	10.7
Haematopoietic and lymphoid	MOLT16	9.3
Haematopoietic and lymphoid	MOLT4	9.5
Haematopoietic and lymphoid	MONOMAC1	10.2
Haematopoietic and lymphoid	MONOMAC6	9.9
Haematopoietic and lymphoid	MOTN1	7.7
Haematopoietic and lymphoid	MUTZ5	9.7
Haematopoietic and lymphoid	MV411	9.4
Haematopoietic and lymphoid	NALM19	9.5
Haematopoietic and lymphoid	NALM1	9.7
Haematopoietic and lymphoid	NALM6	9.3
Haematopoietic and lymphoid	NAMALWA	8.1
Haematopoietic and lymphoid	NB4	9.9
Haematopoietic and lymphoid	NCIH929	8
Haematopoietic and lymphoid	NCO2	9
Haematopoietic and lymphoid	NOMO1	10.4
Haematopoietic and lymphoid	NUDHL1	7.8
Haematopoietic and lymphoid	NUDUL1	8.8
Haematopoietic and lymphoid	OCIAML2	9
Haematopoietic and lymphoid	OCIAML3	10.4
Haematopoietic and lymphoid	OCIAML5	9.9
Haematopoietic and lymphoid	OCILY10	6.3
Haematopoietic and lymphoid	OCILY19	10.2
Haematopoietic and lymphoid	OCILY3	7.3
Haematopoietic and lymphoid	OCIM1	9.6
Haematopoietic and lymphoid	OPM2	7.1
Haematopoietic and lymphoid	P12ICHIKAWA	9.9
Haematopoietic and lymphoid	P31FUJ	8.8
Haematopoietic and lymphoid	P3HR1	6
Haematopoietic and lymphoid	PCM6	7.8
Haematopoietic and lymphoid	PEER	9.9
Haematopoietic and lymphoid	PF382	10
Haematopoietic and lymphoid	PFEIFFER	6.1
Haematopoietic and lymphoid	PL21	9.8
Haematopoietic and lymphoid	RAJI	6.4
Haematopoietic and lymphoid	RCHACV	9.4
Haematopoietic and lymphoid	REC1	6.9
Haematopoietic and lymphoid	REH	8.8
Haematopoietic and lymphoid	RI1	8.4
Haematopoietic and lymphoid	RL	5.7
Haematopoietic and lymphoid	RPMI8226	8.3
Haematopoietic and lymphoid	RPMI8402	8.6
Haematopoietic and lymphoid	RS411	9.3
Haematopoietic and lymphoid	SEM	8.8
Haematopoietic and lymphoid	SET2	9.9
Haematopoietic and lymphoid	SIGM5	9.5
Haematopoietic and lymphoid	SKM1	9.5
Haematopoietic and lymphoid	SKMM2	7.2
Haematopoietic and lymphoid	SR786	9.1
Haematopoietic and lymphoid	ST486	8.1
Haematopoietic and lymphoid	SUDHL10	6.1
Haematopoietic and lymphoid	SUDHL1	8.1
Haematopoietic and lymphoid	SUDHL4	6.6
Haematopoietic and lymphoid	SUDHL5	6.9
Haematopoietic and lymphoid	SUDHL6	7.9
Haematopoietic and lymphoid	SUDHL8	8.2
Haematopoietic and lymphoid	SUPB15	9.1
Haematopoietic and lymphoid	SUPHD1	6.1
Haematopoietic and lymphoid	SUPM2	8.9
Haematopoietic and lymphoid	SUPT11	7.8
Haematopoietic and lymphoid	SUPT1	9.2
Haematopoietic and lymphoid	TALL1	8.8
Haematopoietic and lymphoid	TF1	10
Haematopoietic and lymphoid	THP1	7.8
Haematopoietic and lymphoid	TO175T	7.1
Haematopoietic and lymphoid	TOLEDO	8.6
Haematopoietic and lymphoid	U266B1	7.1
Haematopoietic and lymphoid	U937	9.1
Haematopoietic and lymphoid	UT7	10
Haematopoietic and lymphoid	WSUDLCL2	6
Kidney	769P	7
Kidney	786O	7
Kidney	A498	5.8
Kidney	A704	6.1
Kidney	ACHN	5.9
Kidney	BFTC909	8.3
Kidney	CAKI1	6.7
Kidney	CAKI2	7
Kidney	CAL54	6.6
Kidney	KMRC1	8.9
Kidney	KMRC20	5.6
Kidney	KMRC2	8
Kidney	KMRC3	6.2
Kidney	OSRC2	6.3
Kidney	RCC10RGB	6.2
Kidney	SNU1272	6.6
Kidney	SNU349	6.7
Kidney	TUHR10TKB	6.8
Kidney	TUHR14TKB	5.2
Kidney	TUHR4TKB	6.5
Kidney	VMRCRCW	5.9
Kidney	VMRCRCZ	6.4
Large intestine	C2BBE1	7
Large intestine	CCK81	7.5
Large intestine	CL11	6.1
Large intestine	CL14	7.8
Large intestine	CL34	5.9
Large intestine	CL40	7.1
Large intestine	COLO205	6.6
Large intestine	COLO320	8.4
Large intestine	COLO678	7.7
Large intestine	CW2	7.5
Large intestine	DLD1	7.1
Large intestine	GP2D	6.7
Large intestine	HCC56	7.6
Large intestine	HCT116	7.9
Large intestine	HCT15	7
Large intestine	HS675T	6.2
Large intestine	HS698T	7.3
Large intestine	HT115	6.1
Large intestine	HT29	6.9
Large intestine	HT55	6.4
Large intestine	KM12	6.3
Large intestine	LOVO	6.5
Large intestine	LS1034	6.6
Large intestine	LS123	8.6
Large intestine	LS180	7.5
Large intestine	LS411N	6.5
Large intestine	LS513	7
Large intestine	MDST8	7.6
Large intestine	NCIH508	7.2
Large intestine	NCIH716	6.6
Large intestine	NCIH747	8.2
Large intestine	OUMS23	9.9
Large intestine	RCM1	6.4
Large intestine	RKO	6.4
Large intestine	SKCO1	7.1
Large intestine	SNU1040	7.6
Large intestine	SNU1197	7.1
Large intestine	SNU175	7
Large intestine	SNU283	6.8
Large intestine	SNU407	8.3
Large intestine	SNU503	9
Large intestine	SNU61	5.7
Large intestine	SNU81	7.1
Large intestine	SNUC1	6.9
Large intestine	SNUC2A	7.9
Large intestine	SNUC4	7.5
Large intestine	SNUC5	7.3
Large intestine	SW1116	5.8
Large intestine	SW1417	7.5
Large intestine	SW1463	6.8
Large intestine	SW403	7.2
Large intestine	SW480	6.3
Large intestine	SW48	6.7
Large intestine	SW620	7
Large intestine	SW837	7.5
Large intestine	SW948	6.8
Large intestine	T84	6.7
Liver	ALEXANDERCELLS	6.8
Liver	C3A	7.6
Liver	HEP3B217	7.5
Liver	HEPG2	7.9
Liver	HLE	6.4
Liver	HLF	7
Liver	HUH1	7.1
Liver	HUH6	8.8
Liver	HUH7	6.9
Liver	JHH1	8.6
Liver	JHH2	8.2
Liver	JHH4	7.5
Liver	JHH5	7.1
Liver	JHH6	7.7
Liver	JHH7	7.9
Liver	LI7	6.4
Liver	PLCPRF5	6.8
Liver	SKHEP1	7.5
Liver	SNU182	8.2
Liver	SNU387	8.4
Liver	SNU398	7.9
Liver	SNU423	7.7
Liver	SNU449	7.2
Liver	SNU475	8.3
Liver	SNU761	6.9
Liver	SNU878	6
Liver	SNU886	6.8
Lung	A549	6.7
Lung	ABC1	8.2
Lung	BEN	7.5
Lung	CAL12T	7.3
Lung	CALU1	7.6
Lung	CALU3	6
Lung	CALU6	6.7
Lung	CHAGOK1	6.8
Lung	COLO668	7.2
Lung	COLO699	7.8
Lung	CORL105	9
Lung	CORL23	8.5
Lung	CORL24	9.6
Lung	CORL279	9.6
Lung	CORL311	8.7
Lung	CORL47	8.1
Lung	CORL51	8.7
Lung	CORL88	8.9
Lung	CORL95	8.7
Lung	CPCN	9.1
Lung	DMS114	8.4
Lung	DMS153	7.7
Lung	DMS273	8.9
Lung	DMS454	6.9
Lung	DMS53	7.3
Lung	DMS79	6.7
Lung	DV90	7.4
Lung	EBC1	8.1
Lung	EPLC272H	9.6
Lung	HARA	6.8
Lung	HCC1171	8.6
Lung	HCC1195	7.2
Lung	HCC15	7.6
Lung	HCC2279	7.2
Lung	HCC2935	8
Lung	HCC33	9.6
Lung	HCC366	7.7
Lung	HCC4006	5.6
Lung	HCC44	8.7
Lung	HCC78	6.6
Lung	HCC827	7.4
Lung	HCC95	8.1
Lung	HLC1	7.6
Lung	HLFA	6.7
Lung	HS229T	6.9
Lung	HS618T	6.5
Lung	IALM	8.6
Lung	KNS62	5.4
Lung	LC1F	8.7
Lung	LC1SQSF	8.2
Lung	LCLC103H	8.2
Lung	LCLC97TM1	7.6
Lung	LK2	8.5
Lung	LOUNH91	6.9
Lung	LU65	7.5
Lung	LU99	7.8
Lung	LUDLU1	7.9
Lung	LXF289	9.2
Lung	MORCPR	8.3
Lung	NCIH1048	8.8
Lung	NCIH1092	6.7
Lung	NCIH1105	8
Lung	NCIH1155	7
Lung	NCIH1184	8.2
Lung	NCIH1299	6.8
Lung	NCIH1339	8.1
Lung	NCIH1341	7.9
Lung	NCIH1355	8
Lung	NCIH1373	7.5
Lung	NCIH1385	7.5
Lung	NCIH1395	6.2
Lung	NCIH1435	7.3
Lung	NCIH1436	8
Lung	NCIH1437	7.5
Lung	NCIH146	7.9
Lung	NCIH1563	5.9
Lung	NCIH1568	6.7
Lung	NCIH1573	6.9
Lung	NCIH1581	7.7
Lung	NCIH1618	8.6
Lung	NCIH1623	9.3
Lung	NCIH1648	7.9
Lung	NCIH1650	4
Lung	NCIH1651	7.2
Lung	NCIH1666	7.9
Lung	NCIH1693	7.2
Lung	NCIH1694	8.7
Lung	NCIH1703	7
Lung	NCIH1734	7.5
Lung	NCIH1755	7.5
Lung	NCIH1781	7.2
Lung	NCIH1792	6.4
Lung	NCIH1793	7.5
Lung	NCIH1836	7.6
Lung	NCIH1838	5.8
Lung	NCIH1869	7.6
Lung	NCIH1876	8.9
Lung	NCIH1915	8.7
Lung	NCIH1930	7.7
Lung	NCIH1944	6.8
Lung	NCIH1963	8.3
Lung	NCIH196	7.7
Lung	NCIH1975	7.5
Lung	NCIH2009	7.3
Lung	NCIH2023	6.3
Lung	NCIH2029	8.4
Lung	NCIH2030	6.9
Lung	NCIH2066	7.6
Lung	NCIH2081	7.6
Lung	NCIH2085	8.2
Lung	NCIH2087	6.4
Lung	NCIH209	8.6
Lung	NCIH2106	8.9
Lung	NCIH2110	8.3
Lung	NCIH211	7.8
Lung	NCIH2122	6.7
Lung	NCIH2126	8.1
Lung	NCIH2141	7.8
Lung	NCIH2170	7.2
Lung	NCIH2171	10.4
Lung	NCIH2172	8.3
Lung	NCIH2196	7.4
Lung	NCIH2227	8.2
Lung	NCIH2228	7
Lung	NCIH226	6.4
Lung	NCIH2286	6.4
Lung	NCIH2291	6.3
Lung	NCIH2342	7.6
Lung	NCIH2347	7.8
Lung	NCIH23	7.1
Lung	NCIH2405	6.8
Lung	NCIH2444	8.8
Lung	NCIH292	8
Lung	NCIH322	7.1
Lung	NCIH3255	7
Lung	NCIH358	8.2
Lung	NCIH441	7.8
Lung	NCIH446	8.3
Lung	NCIH460	6
Lung	NCIH510	7.5
Lung	NCIH520	7.6
Lung	NCIH522	9.2
Lung	NCIH524	9.5
Lung	NCIH526	8.7
Lung	NCIH596	8
Lung	NCIH647	7
Lung	NCIH650	8
Lung	NCIH661	7
Lung	NCIH69	8.4
Lung	NCIH727	6.9
Lung	NCIH810	7
Lung	NCIH82	10.1
Lung	NCIH838	7.3
Lung	NCIH841	7.9
Lung	NCIH854	7.6
Lung	NCIH889	7.2
Lung	PC14	8.5
Lung	RERFLCAD1	6.6
Lung	RERFLCAD2	7.2
Lung	RERFLCAI	7.2
Lung	RERFLCKJ	7.7
Lung	RERFLCMS	7
Lung	RERFLCSQ1	8.5
Lung	SBC5	7.3
Lung	SCLC21H	9.2
Lung	SHP77	7.2
Lung	SKLU1	7.3
Lung	SKMES1	7.5
Lung	SQ1	7.1
Lung	SW1271	8.3
Lung	SW1573	6.7
Lung	SW900	7.3
Lung	VMRCLCD	6.8
Lung	VMRCLCP	7.8
Oesophagus	COLO680N	8.8
Oesophagus	ECGI10	8.5
Oesophagus	KYSE140	7.8
Oesophagus	KYSE150	7.7
Oesophagus	KYSE180	7.9
Oesophagus	KYSE270	8
Oesophagus	KYSE30	8.7
Oesophagus	KYSE410	8.3
Oesophagus	KYSE450	7.5
Oesophagus	KYSE510	7.8
Oesophagus	KYSE520	7.8
Oesophagus	KYSE70	8
Oesophagus	OE19	7.1
Oesophagus	OE33	7.5
Oesophagus	TE10	8.2
Oesophagus	TE11	8.1
Oesophagus	TE14	6.7
Oesophagus	TE15	7.8
Oesophagus	TE1	7.7
Oesophagus	TE4	7.1
Oesophagus	TE5	7.7
Oesophagus	TE6	8.4
Oesophagus	TE8	8.5
Oesophagus	TE9	8.1
Oesophagus	TT	8.7
Ovary	59M	7.9
Ovary	A2780	7.6
Ovary	CAOV3	7
Ovary	CAOV4	6.3
Ovary	COLO704	7.5
Ovary	COV318	7.8
Ovary	COV362	6.9
Ovary	COV434	7.1
Ovary	COV504	7.2
Ovary	COV644	7.5
Ovary	EFO21	9
Ovary	EFO27	8.3
Ovary	ES2	5.9
Ovary	FUOV1	8.2
Ovary	HEYA8	7.3
Ovary	HS571T	6.7
Ovary	IGROV1	7.5
Ovary	JHOC5	7.7
Ovary	JHOM1	8.2
Ovary	JHOM2B	6.7
Ovary	JHOS2	6.9
Ovary	JHOS4	7
Ovary	KURAMOCHI	8
Ovary	MCAS	8.5
Ovary	NIHOVCAR3	7.4
Ovary	OAW28	7.6
Ovary	OAW42	7.3
Ovary	OC314	6.5
Ovary	OC316	6.4
Ovary	ONCODG1	7.2
Ovary	OV56	8.9
Ovary	OV7	7.4
Ovary	OV90	7.3
Ovary	OVCAR4	8.3
Ovary	OVCAR8	8.9
Ovary	OVISE	7.5
Ovary	OVK18	7.7
Ovary	OVKATE	5.4
Ovary	OVMANA	6.7
Ovary	OVSAHO	6.9
Ovary	OVTOKO	6.5
Ovary	RMGI	7
Ovary	RMUGS	7.7
Ovary	SKOV3	7.8
Ovary	SNU119	6.7
Ovary	SNU840	7.1
Ovary	SNU8	7.7
Ovary	TOV112D	6.9
Ovary	TOV21G	7
Ovary	TYKNU	6.2
Pancreas	ASPC1	6.2
Pancreas	BXPC3	7.3
Pancreas	CAPAN1	7.5
Pancreas	CAPAN2	7.6
Pancreas	CFPAC1	8.2
Pancreas	DANG	8
Pancreas	HPAC	8.4
Pancreas	HPAFII	6.4
Pancreas	HS766T	6.7
Pancreas	HUPT3	6.5
Pancreas	HUPT4	7
Pancreas	KCIMOH1	7.1
Pancreas	KLM1	7.7
Pancreas	KP2	7.8
Pancreas	KP3	6.3
Pancreas	KP4	6.8
Pancreas	L33	7.5
Pancreas	MIAPACA2	5.9
Pancreas	PANC0203	6.8
Pancreas	PANC0213	8.9
Pancreas	PANC0327	7.4
Pancreas	PANC0403	7.1
Pancreas	PANC0504	6.8
Pancreas	PANC0813	7.9
Pancreas	PANC1005	7.5
Pancreas	PANC1	5.6
Pancreas	PATU8902	7
Pancreas	PATU8988S	6.2
Pancreas	PATU8988T	7.9
Pancreas	PK1	7.1
Pancreas	PK45H	7.4
Pancreas	PK59	7.6
Pancreas	PL45	7.8
Pancreas	PSN1	7
Pancreas	QGP1	7.9
Pancreas	SNU213	7.6
Pancreas	SNU324	8
Pancreas	SNU410	7
Pancreas	SU8686	6.2
Pancreas	SUIT2	5.6
Pancreas	SW1990	6.2
Pancreas	T3M4	7
Pancreas	TCCPAN2	6.3
Pancreas	YAPC	6.9
Pleura	ACCMESO1	6
Pleura	DM3	7.3
Pleura	ISTMES1	6.6
Pleura	ISTMES2	6.3
Pleura	JL1	6.9
Pleura	MPP89	7.9
Pleura	MSTO211H	7
Pleura	NCIH2052	6.7
Pleura	NCIH2452	6.3
Pleura	NCIH28	6.3
Prostate	22RV1	6.5
Prostate	DU145	6.6
Prostate	LNCAPCLONEFGC	7.4
Prostate	MDAPCA2B	7.1
Prostate	NCIH660	7.2
Prostate	PC3	6.8
Prostate	VCAP	6.7
Salivary gland	A253	8.2
Salivary gland	YD15	7.3
Skin	A101D	8
Skin	A2058	8.9
Skin	A375	7.7
Skin	C32	7.7
Skin	CHL1	7.9
Skin	CJM	7.7
Skin	COLO679	8.6
Skin	COLO741	9.9
Skin	COLO783	7.7
Skin	COLO792	9.6
Skin	COLO800	9
Skin	COLO818	8.1
Skin	COLO829	9.7
Skin	COLO849	9.1
Skin	G361	8.2
Skin	GRM	6.6
Skin	HMCB	8.1
Skin	HS294T	8.7
Skin	HS600T	6.8
Skin	HS688AT	6.6
Skin	HS695T	7.9
Skin	HS839T	6.7
Skin	HS852T	8.4
Skin	HS895T	6.8
Skin	HS934T	6.8
Skin	HS936T	7.8
Skin	HS939T	8.7
Skin	HS940T	7.1
Skin	HS944T	8.9
Skin	HT144	8.6
Skin	IGR1	9.2
Skin	IGR37	8
Skin	IGR39	6.4
Skin	IPC298	7.7
Skin	K029AX	8
Skin	LOXIMVI	8.4
Skin	MALME3M	8.5
Skin	MDAMB435S	6.5
Skin	MELHO	9
Skin	MELJUSO	7.8
Skin	MEWO	9
Skin	RPMI7951	7.6
Skin	RVH421	8.7
Skin	SH4	8.8
Skin	SKMEL1	8.4
Skin	SKMEL24	8.2
Skin	SKMEL28	8.3
Skin	SKMEL2	8.6
Skin	SKMEL30	8.6
Skin	SKMEL31	8.4
Skin	SKMEL3	8.4
Skin	SKMEL5	9
Skin	UACC257	8.4
Skin	UACC62	7.3
Skin	WM115	9.2
Skin	WM1799	8.1
Skin	WM2664	8.2
Skin	WM793	8.3
Skin	WM88	8.9
Skin	WM983B	8.5
Small intestine	HUTU80	7.8
Soft tissue	A204	7.5
Soft tissue	G401	7.6
Soft tissue	G402	4.8
Soft tissue	GCT	8
Soft tissue	HS729	6.7
Soft tissue	HT1080	7.5
Soft tissue	KYM1	7.1
Soft tissue	MESSA	8.1
Soft tissue	RD	7
Soft tissue	RH30	7.5
Soft tissue	RH41	9
Soft tissue	RKN	7.8
Soft tissue	S117	8.3
Soft tissue	SJRH30	8.4
Soft tissue	SKLMS1	6.6
Soft tissue	SKUT1	7.2
Soft tissue	TE125T	6.8
Soft tissue	TE159T	6.8
Soft tissue	TE441T	8.3
Soft tissue	TE617T	7.4
Stomach	2313287	7.3
Stomach	AGS	8.2
Stomach	AZ521	7.7
Stomach	ECC10	8.3
Stomach	ECC12	7.9
Stomach	FU97	7.7
Stomach	GCIY	6.7
Stomach	GSS	7.5
Stomach	GSU	7.2
Stomach	HGC27	6.8
Stomach	HS746T	8.6
Stomach	HUG1N	6.5
Stomach	IM95	6.7
Stomach	KATOIII	6.6
Stomach	KE39	6.9
Stomach	LMSU	8
Stomach	MKN1	7.8
Stomach	MKN45	7.5
Stomach	MKN74	7.2
Stomach	MKN7	8
Stomach	NCCSTCK140	9.1
Stomach	NCIN87	7.1
Stomach	NUGC2	8.6
Stomach	NUGC3	8.6
Stomach	NUGC4	6.9
Stomach	OCUM1	5.8
Stomach	RERFGC1B	8
Stomach	SH10TC	5
Stomach	SNU16	7.1
Stomach	SNU1	5.6
Stomach	SNU216	8.2
Stomach	SNU520	6.8
Stomach	SNU5	5.7
Stomach	SNU601	7.6
Stomach	SNU620	6.9
Stomach	SNU668	6.2
Stomach	SNU719	7.5
Stomach	TGBC11TKB	7.1
Thyroid	8305C	7.9
Thyroid	8505C	6.7
Thyroid	BCPAP	8
Thyroid	BHT101	7
Thyroid	CAL62	8.4
Thyroid	CGTHW1	7.8
Thyroid	FTC133	6.9
Thyroid	FTC238	7.4
Thyroid	ML1	6.7
Thyroid	SW579	7.4
Thyroid	TT2609C02	7
Thyroid	TT	8.7
Upper aerodigestive tract	BHY	9
Upper aerodigestive tract	BICR16	8.3
Upper aerodigestive tract	BICR18	7.1
Upper aerodigestive tract	BICR22	8.7
Upper aerodigestive tract	BICR31	7.8
Upper aerodigestive tract	BICR56	8.7
Upper aerodigestive tract	BICR6	7.6
Upper aerodigestive tract	CAL27	7.9
Upper aerodigestive tract	CAL33	8.4
Upper aerodigestive tract	DETROIT562	7.1
Upper aerodigestive tract	FADU	7.3
Upper aerodigestive tract	HS840T	6.5
Upper aerodigestive tract	HSC2	8.7
Upper aerodigestive tract	HSC3	7.8
Upper aerodigestive tract	HSC4	8.3
Upper aerodigestive tract	PECAPJ15	8.5
Upper aerodigestive tract	PECAPJ34CLONEC12	7.5
Upper aerodigestive tract	PECAPJ41CLONED2	7.9
Upper aerodigestive tract	PECAPJ49	8.2
Upper aerodigestive tract	SCC15	8.2
Upper aerodigestive tract	SCC25	9.3
Upper aerodigestive tract	SCC4	8.6
Upper aerodigestive tract	SCC9	8.8
Upper aerodigestive tract	SNU1076	7.7
Upper aerodigestive tract	SNU1214	7.1
Upper aerodigestive tract	SNU46	7
Upper aerodigestive tract	SNU899	7.3
Upper aerodigestive tract	YD10B	8.5
Upper aerodigestive tract	YD38	8.4
Upper aerodigestive tract	YD8	7.3
Urinary tract	5637	8.1
Urinary tract	639V	6.8
Urinary tract	647V	8.9
Urinary tract	BC3C	7.4
Urinary tract	BFTC905	8.5
Urinary tract	CAL29	8.1
Urinary tract	HS172T	6
Urinary tract	HT1197	8.2
Urinary tract	HT1376	7.6
Urinary tract	J82	8.2
Urinary tract	JMSU1	8.6
Urinary tract	KMBC2	8.1
Urinary tract	KU1919	8
Urinary tract	RT11284	7.4
Urinary tract	RT112	7.1
Urinary tract	RT4	7.6
Urinary tract	SCABER	8
Urinary tract	SW1710	7.1
Urinary tract	SW780	7.1
Urinary tract	T24	6.5
Urinary tract	TCCSUP	6.8
Urinary tract	UMUC1	7.4
Urinary tract	UMUC3	7.1
Urinary tract	VMCUB1	7.8

> The Human Protein Atlas (HPA)

[ TOP ]

Tissue	Expression Level (TPM)
Adipose tissue	8.6
Adrenal gland	5.1
Appendix	12.9
Bone marrow	36.6
Breast	6.9
Cerebral cortex	12.7
Cervix, uterine	5.1
Colon	4.5
Duodenum	6
Endometrium	8.5
Epididymis	8.2
Esophagus	9.8
Fallopian tube	5.3
Gallbladder	7.2
Heart muscle	3.3
Kidney	2.9
Liver	1.5
Lung	7.4
Lymph node	10.9
Ovary	6.9
Pancreas	0.7
Parathyroid gland	7.5
Placenta	10.5
Prostate	5.7
Rectum	5.3
Salivary gland	2.7
Seminal vesicle	4.8
Skeletal muscle	4.1
Skin	14.2
Small intestine	6.8
Smooth muscle	6.1
Spleen	15
Stomach	6.8
Testis	30.7
Thyroid gland	5.4
Tonsil	9.6
Urinary bladder	6.7

> Text Mining based Expression

[ TOP ]

PMID	Expression	Cancer	Evidence
27259236	Overexpression	Hepatocellular Carcinoma	This study found that JARID2 expression was significantly higher in HCC tissues than that in adjacent non-tumor liver tissues (ANLTs), and its expression level correlated with HCC metastasis.
25939703	Underexpression	Leukemia	JARID2 is down-regulated in B-chronic lymphocytic leukemia (B-CLL) and acute monocytic leukemia (AMOL)
28445934	Overexpression	Bladder Carcinoma	Conversely, ectopic overexpression of Jarid2 promoted the invasive ability and sphere-forming capacity in bladder cancer cells.
27641964	Overexpression	Glioma	Our data indicate that JARID2 is upregulated in human glioma tissues and cell lines.

Summary
Symbol	JARID2
Name	jumonji and AT-rich interaction domain containing 2
Aliases	JMJ; jumonji (mouse) homolog; jumonji homolog; jumonji-like protein; jumonji/ARID domain-containing protein ......
Location	6p22.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Somatic copy number alteration in primary tomur tissue

> The Cancer Genome Atlas (TCGA)

[ TOP ]

Correlation between expression and SCNA as well as percentage of patients in different status.

Cancer	Full Name	# Sample	R	P	% Loss	% Neutral	% Gain	Status
BLCA	Bladder urothelial carcinoma	404	0.5	5.91e-27	16.3	48.8	34.9	Gain
BRCA	Breast invasive carcinoma	1075	0.512	8.47e-73	12.8	60.5	26.7	Neutral
CESC	Cervical and endocervical cancers	292	0.256	9.81e-06	15.1	61	24	Neutral
COAD	Colon adenocarcinoma	449	0.402	7.79e-19	11.1	70.4	18.5	Neutral
ESCA	Esophageal carcinoma	183	0.381	1.03e-07	31.7	46.4	21.9	Neutral
GBM	Glioblastoma multiforme	147	0.108	0.195	19.7	75.5	4.8	Neutral
HNSC	Head and Neck squamous cell carcinoma	514	0.397	7.73e-21	16.9	64.6	18.5	Neutral
KIRC	Kidney renal clear cell carcinoma	525	0.376	4.02e-19	18.3	79.8	1.9	Neutral
KIRP	Kidney renal papillary cell carcinoma	288	0.165	0.0051	9.4	88.9	1.7	Neutral
LAML	Acute Myeloid Leukemia	166	-0.052	0.504	0	100	0	Neutral
LGG	Brain Lower Grade Glioma	513	0.306	1.45e-12	7	90.4	2.5	Neutral
LIHC	Liver hepatocellular carcinoma	364	0.439	1.28e-18	3	55.2	41.8	Gain
LUAD	Lung adenocarcinoma	512	0.4	4.53e-21	12.1	51.4	36.5	Gain
LUSC	Lung squamous cell carcinoma	498	0.345	2.09e-15	26.3	48.6	25.1	Neutral
OV	Ovarian serous cystadenocarcinoma	300	0.62	2.61e-33	17.7	31.3	51	Gain
PAAD	Pancreatic adenocarcinoma	177	0.289	9.42e-05	37.9	57.1	5.1	Loss
PCPG	Pheochromocytoma and Paraganglioma	162	0.229	0.00345	1.2	90.1	8.6	Neutral
PRAD	Prostate adenocarcinoma	491	0.132	0.00335	5.5	90.6	3.9	Neutral
READ	Rectum adenocarcinoma	164	0.323	2.46e-05	11	65.2	23.8	Neutral
SARC	Sarcoma	255	0.429	7.42e-13	28.6	50.6	20.8	Neutral
SKCM	Skin Cutaneous Melanoma	367	0.607	2.4e-38	6.3	36.5	57.2	Gain
STAD	Stomach adenocarcinoma	413	0.367	1.3e-14	16.2	63.4	20.3	Neutral
TGCT	Testicular Germ Cell Tumors	150	0.064	0.439	16	64.7	19.3	Neutral
THCA	Thyroid carcinoma	497	0.112	0.0122	0.8	98.8	0.4	Neutral
THYM	Thymoma	119	0.613	1.21e-13	17.6	82.4	0	Neutral
UCEC	Uterine Corpus Endometrial Carcinoma	537	0.379	8.99e-20	3.4	78.6	18.1	Neutral

Summary
Symbol	JARID2
Name	jumonji and AT-rich interaction domain containing 2
Aliases	JMJ; jumonji (mouse) homolog; jumonji homolog; jumonji-like protein; jumonji/ARID domain-containing protein ......
Location	6p22.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Methylation level in the promoter region of CR

> Methylation level in the promoter region of CR

[ TOP ]

Correlation between expression and methylation as well as differential methylation analysis.

Cancer	Full Name	R	P	# N	# T	Delta beta (T vs N)	P value (T vs N)	Status
BLCA	Bladder urothelial carcinoma	-0.172	0.000366	17	408	-0.006	0.13	NS/NA
BRCA	Breast invasive carcinoma	-0.206	1.07e-09	83	785	-0.013	0.00167	NS/NA
CESC	Cervical and endocervical cancers	-0.189	0.000868	3	306	NA	NA	NS/NA
COAD	Colon adenocarcinoma	-0.265	1.93e-06	19	297	-0.002	0.53	NS/NA
ESCA	Esophageal carcinoma	-0.293	3.66e-05	9	185	NA	NA	NS/NA
GBM	Glioblastoma multiforme	-0.309	0.0125	1	64	NA	NA	NS/NA
HNSC	Head and Neck squamous cell carcinoma	-0.148	0.000578	20	522	0.005	0.00484	NS/NA
KIRC	Kidney renal clear cell carcinoma	-0.207	0.000114	24	319	-0.008	0.189	NS/NA
KIRP	Kidney renal papillary cell carcinoma	-0.227	7.81e-05	23	275	0.005	0.128	NS/NA
LAML	Acute Myeloid Leukemia	-0.12	0.118	0	170	NA	NA	NS/NA
LGG	Brain Lower Grade Glioma	-0.059	0.177	0	530	NA	NA	NS/NA
LIHC	Liver hepatocellular carcinoma	-0.331	6.45e-12	41	373	-0.002	0.633	NS/NA
LUAD	Lung adenocarcinoma	-0.157	0.000583	21	456	-0.024	0.000569	NS/NA
LUSC	Lung squamous cell carcinoma	-0.146	0.00436	8	370	NA	NA	NS/NA
OV	Ovarian serous cystadenocarcinoma	-0.983	4.96e-05	0	9	NA	NA	NS/NA
PAAD	Pancreatic adenocarcinoma	-0.25	0.000669	4	179	NA	NA	NS/NA
PCPG	Pheochromocytoma and Paraganglioma	-0.133	0.0689	3	184	NA	NA	NS/NA
PRAD	Prostate adenocarcinoma	-0.031	0.479	35	498	0.002	0.63	NS/NA
READ	Rectum adenocarcinoma	-0.319	0.00121	2	99	NA	NA	NS/NA
SARC	Sarcoma	-0.299	8.88e-07	0	263	NA	NA	NS/NA
SKCM	Skin Cutaneous Melanoma	-0.389	0	1	471	NA	NA	NS/NA
STAD	Stomach adenocarcinoma	-0.204	7.59e-05	0	372	NA	NA	NS/NA
TGCT	Testicular Germ Cell Tumors	-0.288	0.000275	0	156	NA	NA	NS/NA
THCA	Thyroid carcinoma	-0.045	0.289	50	509	-0.009	0.0275	NS/NA
THYM	Thymoma	-0.38	1.83e-05	2	120	NA	NA	NS/NA
UCEC	Uterine Corpus Endometrial Carcinoma	-0.219	1.93e-06	34	431	-0.023	0.00325	NS/NA

Summary
Symbol	JARID2
Name	jumonji and AT-rich interaction domain containing 2
Aliases	JMJ; jumonji (mouse) homolog; jumonji homolog; jumonji-like protein; jumonji/ARID domain-containing protein ......
Location	6p22.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Primary tumor tissue from TCGA > Normal tumor tissue from HPA

>The Cancer Genome Atlas (TCGA) [ TOP ]
There is no record.

> The Human Protein Atlas (HPA)

[ TOP ]

Tissue	Level	Level Name
Adrenal gland	3	High
Appendix	2	Medium
Bone marrow	3	High
Breast	2	Medium
Bronchus	3	High
Caudate	2	Medium
Cerebellum	2	Medium
Cerebral cortex	3	High
Cervix, uterine	3	High
Colon	2	Medium
Duodenum	2	Medium
Endometrium	3	High
Epididymis	3	High
Esophagus	2	Medium
Fallopian tube	2	Medium
Gallbladder	2	Medium
Heart muscle	3	High
Hippocampus	2	Medium
Kidney	3	High
Liver	2	Medium
Lung	2	Medium
Lymph node	2	Medium
Nasopharynx	3	High
Oral mucosa	3	High
Ovary	2	Medium
Pancreas	2	Medium
Parathyroid gland	2	Medium
Placenta	3	High
Prostate	2	Medium
Rectum	3	High
Salivary gland	3	High
Seminal vesicle	2	Medium
Skeletal muscle	3	High
Skin	2	Medium
Small intestine	2	Medium
Smooth muscle	3	High
Soft tissue	1	Low
Spleen	2	Medium
Stomach	3	High
Testis	2	Medium
Thyroid gland	3	High
Tonsil	2	Medium
Urinary bladder	2	Medium
Vagina	2	Medium

Summary
Symbol	JARID2
Name	jumonji and AT-rich interaction domain containing 2
Aliases	JMJ; jumonji (mouse) homolog; jumonji homolog; jumonji-like protein; jumonji/ARID domain-containing protein ......
Location	6p22.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Association between expresson and subtype > Overall survival analysis based on expression > Association between expresson and stage > Association between expresson and grade

> Subtype

[ TOP ]

Association between expresson and subtype.

Cancer	Full Name	# Patients	P Value (Kruskal-Wallis)	Association	Source
BLCA	Bladder urothelial carcinoma	128	0.25	NS	24476821
BRCA	Breast invasive carcinoma	521	3.03e-06	Significant	23000897
COAD	Colon adenocarcinoma	149	4.32e-07	Significant	22810696
GBM	Glioblastoma multiforme	157	1.12e-06	Significant	26824661
HNSC	Head and Neck squamous cell carcinoma	279	1.85e-05	Significant	25631445
KIRP	Kidney renal papillary cell carcinoma	161	0.0617	NS	26536169
LGG	Brain Lower Grade Glioma	513	9.1e-28	Significant	26824661
LUAD	Lung adenocarcinoma	230	0.00599	Significant	25079552
LUSC	Lung squamous cell carcinoma	178	0.000538	Significant	22960745
OV	Ovarian serous cystadenocarcinoma	287	1.33e-11	Significant	21720365
PRAD	Prostate adenocarcinoma	333	0.0109	Significant	26544944
READ	Rectum adenocarcinoma	67	0.093	NS	22810696
SKCM	Skin Cutaneous Melanoma	315	7.56e-05	Significant	26091043
STAD	Stomach adenocarcinoma	277	7.65e-09	Significant	25079317
THCA	Thyroid carcinoma	391	0.0302	Significant	25417114
UCEC	Uterine Corpus Endometrial Carcinoma	232	0.184	NS	23636398

> Overall survival

[ TOP ]

Overall survival analysis based on expression.

Cancer	Full Name	# Patients	Hazard Ratio	P Value (Log Rank Test)	Association
BLCA	Bladder urothelial carcinoma	405	1.011	0.957	NS
BRCA	Breast invasive carcinoma	1079	1.396	0.138	NS
CESC	Cervical and endocervical cancers	291	1.083	0.816	NS
COAD	Colon adenocarcinoma	439	1.101	0.747	NS
ESCA	Esophageal carcinoma	184	1.019	0.957	NS
GBM	Glioblastoma multiforme	158	0.761	0.301	NS
HNSC	Head and Neck squamous cell carcinoma	518	0.839	0.355	NS
KIRC	Kidney renal clear cell carcinoma	531	1.094	0.666	NS
KIRP	Kidney renal papillary cell carcinoma	287	0.86	0.703	NS
LAML	Acute Myeloid Leukemia	149	0.565	0.047	Longer
LGG	Brain Lower Grade Glioma	511	0.458	0.00106	Longer
LIHC	Liver hepatocellular carcinoma	365	1.237	0.387	NS
LUAD	Lung adenocarcinoma	502	1.011	0.958	NS
LUSC	Lung squamous cell carcinoma	494	1.079	0.697	NS
OV	Ovarian serous cystadenocarcinoma	303	1.278	0.246	NS
PAAD	Pancreatic adenocarcinoma	177	0.958	0.886	NS
PCPG	Pheochromocytoma and Paraganglioma	179	1.036	0.98	NS
PRAD	Prostate adenocarcinoma	497	3.405	0.32	NS
READ	Rectum adenocarcinoma	159	0.417	0.134	NS
SARC	Sarcoma	259	1.701	0.053	NS
SKCM	Skin Cutaneous Melanoma	459	1.713	0.00441	Shorter
STAD	Stomach adenocarcinoma	388	1.231	0.363	NS
TGCT	Testicular Germ Cell Tumors	134	1314863166.63	0.129	NS
THCA	Thyroid carcinoma	500	1.63	0.59	NS
THYM	Thymoma	119	0	0.00423	Longer
UCEC	Uterine Corpus Endometrial Carcinoma	543	1.778	0.0546	NS

> Stage

[ TOP ]

Association between expresson and stage.

Cancer	Full Name	# Patients	R Value (Spearman)	P Value (Spearman)	Association
BLCA	Bladder urothelial carcinoma	406	-0.069	0.167	NS
BRCA	Breast invasive carcinoma	1071	0.031	0.316	NS
CESC	Cervical and endocervical cancers	167	0.01	0.899	NS
COAD	Colon adenocarcinoma	445	0.084	0.0758	NS
ESCA	Esophageal carcinoma	162	-0.109	0.167	NS
HNSC	Head and Neck squamous cell carcinoma	448	-0.096	0.0429	Lower
KIRC	Kidney renal clear cell carcinoma	531	-0.045	0.306	NS
KIRP	Kidney renal papillary cell carcinoma	260	-0.013	0.839	NS
LIHC	Liver hepatocellular carcinoma	347	0.12	0.0249	Higher
LUAD	Lung adenocarcinoma	507	0.033	0.46	NS
LUSC	Lung squamous cell carcinoma	497	-0.045	0.312	NS
OV	Ovarian serous cystadenocarcinoma	302	-0.117	0.0419	Lower
PAAD	Pancreatic adenocarcinoma	176	-0.049	0.515	NS
READ	Rectum adenocarcinoma	156	0.024	0.768	NS
SKCM	Skin Cutaneous Melanoma	410	-0.094	0.0578	NS
STAD	Stomach adenocarcinoma	392	0.071	0.158	NS
TGCT	Testicular Germ Cell Tumors	81	0.266	0.0165	Higher
THCA	Thyroid carcinoma	499	-0.088	0.0483	Lower
UCEC	Uterine Corpus Endometrial Carcinoma	501	0.01	0.824	NS

> Grade

[ TOP ]

Association between expresson and grade.

Cancer	Full Name	# Patients	R Value (Spearman)	P Value (Spearman)	Association
CESC	Cervical and endocervical cancers	272	-0.052	0.397	NS
HNSC	Head and Neck squamous cell carcinoma	498	-0.288	6.17e-11	Lower
KIRC	Kidney renal clear cell carcinoma	525	-0.057	0.191	NS
LGG	Brain Lower Grade Glioma	514	-0.149	0.000698	Lower
LIHC	Liver hepatocellular carcinoma	366	0.209	5.5e-05	Higher
OV	Ovarian serous cystadenocarcinoma	296	-0.027	0.641	NS
PAAD	Pancreatic adenocarcinoma	176	0.008	0.914	NS
STAD	Stomach adenocarcinoma	406	-0.047	0.344	NS
UCEC	Uterine Corpus Endometrial Carcinoma	534	0.072	0.0963	NS

Summary
Symbol	JARID2
Name	jumonji and AT-rich interaction domain containing 2
Aliases	JMJ; jumonji (mouse) homolog; jumonji homolog; jumonji-like protein; jumonji/ARID domain-containing protein ......
Location	6p22.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Targets inferred by reverse engineering method > Targets identified by ChIP-seq data

> Targets inferred by reverse engineering method [ TOP ]

> Targets identified by ChIP-seq data [ TOP ]

Summary
Symbol	JARID2
Name	jumonji and AT-rich interaction domain containing 2
Aliases	JMJ; jumonji (mouse) homolog; jumonji homolog; jumonji-like protein; jumonji/ARID domain-containing protein ......
Location	6p22.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Drugs from DrugBank database

> Drugs from DrugBank database [ TOP ]
There is no record for JARID2.

Summary
Symbol	JARID2
Name	jumonji and AT-rich interaction domain containing 2
Aliases	JMJ; jumonji (mouse) homolog; jumonji homolog; jumonji-like protein; jumonji/ARID domain-containing protein ......
Location	6p22.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Protein-Protein Interaction Network > miRNA Regulatory Relationship > Interactions from Text Mining

> Protein-Protein Interaction Network [ TOP ]

> miRNA Regulatory Relationship [ TOP ]

> Interactions from Text Mining

[ TOP ]

PMID	Cancer	Hierarchy	Gene	Relation to CR	Evidence
27259236	Hepatocellular Carcinoma	downstream	EMT; AKT; PTEN	Positive regulation; Positive regulation; Negative regulation	Mechanistically, the data showed that JARID2 exerted its function by repressing PTEN expression through increasing H3K27 trimethylation (H3K27me3) at PTEN promoter region, which subsequently resulted in activation of protein kinase B (AKT) and enhanced epithelial-mesenchymal transition (EMT).
25939703	Leukemia	downstream	CCDN1	Negative regulation	Mechanistic studies show that JARID2 negatively regulates CCND1 expression by increasing H3K27 trimethylation on the CCND1 promoter.
28445934	Bladder Carcinoma	downstream	p16	Negative regulation	Mechanistically, reduced Jarid2 expression led to the upregulation of p16 and H3K27me3 level at p16 promoter region.