CR2Cancer

Summary
Symbol	KAT7
Name	lysine acetyltransferase 7
Aliases	HBOA; HBO1; ZC2HC7; histone acetyltransferase binding to ORC1; MYST2; MYST histone acetyltransferase 2; MOZ, ......
Location	17q21.33
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Domain, Function and Classification > Gene Ontology > KEGG and Reactome Pathway

> Domain, Function and Classification

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Domain

PF01853 MOZ/SAS family
PF01530 Zinc finger

Function

Component of the HBO1 complex which has a histone H4-specific acetyltransferase activity, a reduced activity toward histone H3 and is responsible for the bulk of histone H4 acetylation in vivo. Through chromatin acetylation it may regulate DNA replication and act as a coactivator of TP53-dependent transcription. Acts as a coactivator of the licensing factor CDT1 (PubMed:18832067). Specifically represses AR-mediated transcription.

Classification

Class	Modification	Substrate	Product	PubMed
Histone modification write	Histone acetylation	H4	H4ac	10438470

> Gene Ontology [ TOP ]
Biological Process	GO:0006260 DNA replication GO:0006473 protein acetylation GO:0006475 internal protein amino acid acetylation GO:0016570 histone modification GO:0016573 histone acetylation GO:0018205 peptidyl-lysine modification GO:0018393 internal peptidyl-lysine acetylation GO:0018394 peptidyl-lysine acetylation GO:0034504 protein localization to nucleus GO:0043543 protein acylation GO:0043966 histone H3 acetylation GO:0043967 histone H4 acetylation GO:0043981 histone H4-K5 acetylation GO:0043982 histone H4-K8 acetylation GO:0043983 histone H4-K12 acetylation GO:1900180 regulation of protein localization to nucleus GO:1900182 positive regulation of protein localization to nucleus GO:1903829 positive regulation of cellular protein localization
Molecular Function	GO:0004402 histone acetyltransferase activity GO:0008080 N-acetyltransferase activity GO:0016407 acetyltransferase activity GO:0016410 N-acyltransferase activity GO:0016746 transferase activity, transferring acyl groups GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups GO:0034212 peptide N-acetyltransferase activity GO:0061733 peptide-lysine-N-acetyltransferase activity
Cellular Component	GO:0000123 histone acetyltransferase complex GO:0031248 protein acetyltransferase complex GO:1902493 acetyltransferase complex

> KEGG and Reactome Pathway [ TOP ]
KEGG	-
Reactome	R-HSA-3247509: Chromatin modifying enzymes R-HSA-4839726: Chromatin organization R-HSA-3214847: HATs acetylate histones

Summary
Symbol	KAT7
Name	lysine acetyltransferase 7
Aliases	HBOA; HBO1; ZC2HC7; histone acetyltransferase binding to ORC1; MYST2; MYST histone acetyltransferase 2; MOZ, ......
Location	17q21.33
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Mutation landscape in primary tumor tissue from TCGA > Mutation landscape in cancer cell line from CCLE > All mutations from COSMIC database V81 > Variations from text mining

> The Cancer Genome Atlas (TCGA) [ TOP ]

> Cancer Cell Line Encyclopedia (CCLE) [ TOP ]

> Catalogue of Somatic Mutations in Cancer (COSMIC)

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COSMIC ID	CDS change	AA change	Mutation Type	Anatomical Site
COSM5894635	c.1066C>T	p.P356S	Substitution - Missense	Skin
COSM5559448	c.1593G>A	p.L531L	Substitution - coding silent	Prostate
COSM980854	c.1156G>A	p.A386T	Substitution - Missense	Endometrium
COSM707002	c.1747G>A	p.E583K	Substitution - Missense	Lung
COSM980841	c.543C>A	p.F181L	Substitution - Missense	Endometrium
COSM1384121	c.966G>T	p.E322D	Substitution - Missense	Large_intestine
COSM4808335	c.622G>C	p.G208R	Substitution - Missense	Pancreas
COSM1194448	c.1119A>C	p.K373N	Substitution - Missense	Lung
COSM1179497	c.1687C>T	p.Q563*	Substitution - Nonsense	Prostate
COSM321916	c.1765G>T	p.A589S	Substitution - Missense	Lung
COSM1684512	c.1381delT	p.S461fs*22	Deletion - Frameshift	Large_intestine
COSM2698484	c.1081C>T	p.R361W	Substitution - Missense	Large_intestine
COSM1710453	c.1397C>T	p.S466L	Substitution - Missense	Skin
COSM5984877	c.900C>T	p.N300N	Substitution - coding silent	Upper_aerodigestive_tract
COSM24281	c.1513G>A	p.G505S	Substitution - Missense	Lung
COSM4410659	c.326A>G	p.D109G	Substitution - Missense	Kidney
COSM5772351	c.1A>G	p.M1V	Substitution - Missense	Breast
COSM707005	c.167C>T	p.S56F	Substitution - Missense	Lung
COSM1179497	c.1687C>T	p.Q563*	Substitution - Nonsense	Prostate
COSM1384126	c.1525C>T	p.R509C	Substitution - Missense	Large_intestine
COSM1710453	c.1397C>T	p.S466L	Substitution - Missense	Skin
COSM6002571	c.762G>A	p.T254T	Substitution - coding silent	Prostate
COSM980868	c.1643C>T	p.T548M	Substitution - Missense	Endometrium
COSM5427462	c.1647T>C	p.A549A	Substitution - coding silent	Haematopoietic_and_lymphoid_tissue
COSM4410659	c.326A>G	p.D109G	Substitution - Missense	Kidney
COSM5653725	c.1253G>A	p.C418Y	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM2698494	c.1377delT	p.S461fs*22	Deletion - Frameshift	Large_intestine
COSM4410659	c.326A>G	p.D109G	Substitution - Missense	Kidney
COSM980858	c.1199G>A	p.R400H	Substitution - Missense	Endometrium
COSM5614463	c.975G>C	p.R325S	Substitution - Missense	Lung
COSM3819902	c.895G>C	p.E299Q	Substitution - Missense	Breast
COSM1630252	c.1414G>T	p.V472F	Substitution - Missense	Liver
COSM5758954	c.758C>T	p.P253L	Substitution - Missense	Bone
COSM3958510	c.974G>C	p.R325T	Substitution - Missense	Lung
COSM4451010	c.1017A>G	p.T339T	Substitution - coding silent	Skin
COSM4449049	c.163+3delA	p.?	Unknown	Skin
COSM1728547	c.151C>G	p.Q51E	Substitution - Missense	Liver
COSM1610432	c.710C>T	p.S237F	Substitution - Missense	Liver
COSM707004	c.566G>A	p.G189D	Substitution - Missense	Lung
COSM1743594	c.1367T>G	p.L456R	Substitution - Missense	Biliary_tract
COSM2698484	c.1081C>T	p.R361W	Substitution - Missense	Large_intestine
COSM3989118	c.163G>A	p.D55N	Substitution - Missense	Kidney
COSM980862	c.1301T>G	p.L434*	Substitution - Nonsense	Endometrium
COSM980839	c.404C>A	p.S135Y	Substitution - Missense	Endometrium
COSM5771753	c.537C>A	p.Y179*	Substitution - Nonsense	Breast
COSM5646006	c.35C>T	p.S12L	Substitution - Missense	Oesophagus
COSM980864	c.1392G>T	p.K464N	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM707003	c.664-1G>T	p.?	Unknown	Lung
COSM1191149	c.933delA	p.R312fs*13	Deletion - Frameshift	Lung
COSM4754537	c.1145G>A	p.R382H	Substitution - Missense	Stomach
COSM472971	c.1312G>C	p.V438L	Substitution - Missense	Kidney
COSM980870	c.1650G>T	p.V550V	Substitution - coding silent	Endometrium
COSM980847	c.812G>T	p.R271I	Substitution - Missense	Endometrium
COSM4130365	c.1500C>T	p.V500V	Substitution - coding silent	Thyroid
COSM3795755	c.666G>A	p.V222V	Substitution - coding silent	Urinary_tract
COSM128638	c.890_891delTT	p.L298fs*8	Deletion - Frameshift	Upper_aerodigestive_tract
COSM3733560	c.1489C>T	p.L497F	Substitution - Missense	Pancreas
COSM1679902	c.1708G>C	p.G570R	Substitution - Missense	Lung
COSM1630251	c.1147C>T	p.R383W	Substitution - Missense	Liver
COSM3518954	c.1426C>T	p.L476F	Substitution - Missense	Skin
COSM3518955	c.1709G>A	p.G570E	Substitution - Missense	Skin
COSM5755068	c.670G>A	p.A224T	Substitution - Missense	Large_intestine
COSM75541	c.935G>C	p.R312T	Substitution - Missense	Ovary
COSM3717443	c.179G>T	p.R60L	Substitution - Missense	Liver
COSM3958511	c.1726A>G	p.K576E	Substitution - Missense	Lung
COSM5386635	c.775C>T	p.R259*	Substitution - Nonsense	Skin
COSM1216521	c.302G>A	p.G101D	Substitution - Missense	Large_intestine
COSM4410659	c.326A>G	p.D109G	Substitution - Missense	Kidney
COSM1190915	c.932delG	p.R311fs*14	Deletion - Frameshift	Lung
COSM2698476	c.930C>T	p.F310F	Substitution - coding silent	Large_intestine
COSM252636	c.1154T>C	p.M385T	Substitution - Missense	Ovary
COSM5958718	c.107delC	p.R37fs*13	Deletion - Frameshift	Thyroid
COSM1216522	c.398C>T	p.A133V	Substitution - Missense	Large_intestine
COSM377506	c.807G>A	p.K269K	Substitution - coding silent	Lung
COSM4067500	c.191C>A	p.S64Y	Substitution - Missense	Stomach
COSM2698484	c.1081C>T	p.R361W	Substitution - Missense	Large_intestine
COSM3518956	c.1823C>T	p.P608L	Substitution - Missense	Skin
COSM1610432	c.710C>T	p.S237F	Substitution - Missense	Liver
COSM436811	c.1558C>T	p.R520C	Substitution - Missense	Breast
COSM5906052	c.1798C>T	p.P600S	Substitution - Missense	Skin
COSM1302983	c.910G>A	p.E304K	Substitution - Missense	Urinary_tract
COSM980837	c.131G>T	p.R44L	Substitution - Missense	Endometrium
COSM980849	c.843G>T	p.E281D	Substitution - Missense	Endometrium
COSM5964327	c.652G>A	p.D218N	Substitution - Missense	Breast
COSM223888	c.421G>A	p.D141N	Substitution - Missense	Skin
COSM980852	c.1110C>A	p.F370L	Substitution - Missense	Endometrium
COSM5016576	c.100_102delGGC	p.G34delG	Deletion - In frame	Kidney
COSM1384124	c.1505delA	p.V504fs*14	Deletion - Frameshift	Large_intestine
COSM5611907	c.1305T>A	p.Y435*	Substitution - Nonsense	Adrenal_gland
COSM1742215	c.1526G>A	p.R509H	Substitution - Missense	Urinary_tract
COSM4694071	c.1708G>A	p.G570R	Substitution - Missense	Large_intestine
COSM1610432	c.710C>T	p.S237F	Substitution - Missense	Liver
COSM4694068	c.1026T>A	p.F342L	Substitution - Missense	Large_intestine
COSM4067504	c.1509A>C	p.K503N	Substitution - Missense	Stomach
COSM4788603	c.1146C>A	p.R382R	Substitution - coding silent	Liver
COSM3989117	c.18G>T	p.R6S	Substitution - Missense	Kidney
COSM124649	c.53C>T	p.S18F	Substitution - Missense	Upper_aerodigestive_tract
COSM5024023	c.172C>T	p.P58S	Substitution - Missense	Bone
COSM3819901	c.134C>T	p.S45F	Substitution - Missense	Breast
COSM4410659	c.326A>G	p.D109G	Substitution - Missense	Kidney
COSM4067499	c.54C>T	p.S18S	Substitution - coding silent	Stomach
COSM980864	c.1392G>T	p.K464N	Substitution - Missense	Endometrium
COSM980845	c.694G>T	p.E232*	Substitution - Nonsense	Endometrium
COSM124649	c.53C>T	p.S18F	Substitution - Missense	Cervix
COSM189226	c.380G>A	p.R127Q	Substitution - Missense	Large_intestine
COSM4788603	c.1146C>A	p.R382R	Substitution - coding silent	Liver
COSM5747873	c.262A>G	p.T88A	Substitution - Missense	Pancreas
COSM3795754	c.261G>A	p.V87V	Substitution - coding silent	Urinary_tract
COSM5055570	c.1586G>A	p.R529H	Substitution - Missense	Stomach
COSM3518948	c.867C>T	p.T289T	Substitution - coding silent	Skin
COSM3421676	c.266C>T	p.P89L	Substitution - Missense	Large_intestine
COSM1726117	c.1480A>G	p.S494G	Substitution - Missense	Liver
COSM980860	c.1278A>T	p.K426N	Substitution - Missense	Endometrium
COSM2698450	c.61T>C	p.S21P	Substitution - Missense	Large_intestine
COSM4694067	c.468C>T	p.D156D	Substitution - coding silent	Large_intestine
COSM3421675	c.182A>C	p.N61T	Substitution - Missense	Large_intestine
COSM3701236	c.1155+8G>T	p.?	Unknown	Liver
COSM3819903	c.1632C>G	p.I544M	Substitution - Missense	Breast
COSM257479	c.515G>A	p.R172H	Substitution - Missense	Large_intestine
COSM3717443	c.179G>T	p.R60L	Substitution - Missense	Liver
COSM4410659	c.326A>G	p.D109G	Substitution - Missense	Kidney
COSM1579311	c.1517C>T	p.S506F	Substitution - Missense	Fallopian_tube
COSM5788984	c.508C>T	p.P170S	Substitution - Missense	Breast
COSM4933708	c.322G>T	p.V108F	Substitution - Missense	Liver
COSM356049	c.1118A>C	p.K373T	Substitution - Missense	Lung
COSM4694070	c.1559G>A	p.R520H	Substitution - Missense	Large_intestine
COSM4694069	c.1501G>A	p.E501K	Substitution - Missense	Large_intestine
COSM4410659	c.326A>G	p.D109G	Substitution - Missense	Kidney
COSM472970	c.1097A>G	p.Y366C	Substitution - Missense	Kidney
COSM980868	c.1643C>T	p.T548M	Substitution - Missense	Prostate
COSM1216523	c.786A>T	p.E262D	Substitution - Missense	Large_intestine
COSM980856	c.1198C>G	p.R400G	Substitution - Missense	Endometrium
COSM5016577	c.104_122del19	p.T35fs*9	Deletion - Frameshift	Kidney
COSM4067501	c.925C>A	p.L309I	Substitution - Missense	Stomach
COSM5788984	c.508C>T	p.P170S	Substitution - Missense	Breast
COSM344546	c.1389A>G	p.E463E	Substitution - coding silent	Lung
COSM3742300	c.465G>A	p.K155K	Substitution - coding silent	Liver
COSM3518951	c.1067C>T	p.P356L	Substitution - Missense	Skin
COSM4449049	c.163+3delA	p.?	Unknown	Large_intestine
COSM189226	c.380G>A	p.R127Q	Substitution - Missense	Endometrium
COSM24282	c.889C>T	p.L297F	Substitution - Missense	Skin
COSM4410659	c.326A>G	p.D109G	Substitution - Missense	Kidney
COSM980866	c.1585C>T	p.R529C	Substitution - Missense	Endometrium

> Text Mining based Variations [ TOP ]
There is no record for KAT7.

Summary
Symbol	KAT7
Name	lysine acetyltransferase 7
Aliases	HBOA; HBO1; ZC2HC7; histone acetyltransferase binding to ORC1; MYST2; MYST histone acetyltransferase 2; MOZ, ......
Location	17q21.33
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Post-translational modification (PTM)

> Post-translational modification (PTM)

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Filter By:

Uniprot ID	Position	Amino Acid	Description	Upstream Enzyme	Affected By Mutation	Amino Acid Sequence Variant
O95251	50	S	Phosphoserine	-	No	None detected
O95251	57	S	Phosphoserine	PLK1	No	None detected
O95251	64	S	Phosphoserine	-	Yes	p.S64Y (cancer: STAD)
O95251	85	T	Phosphothreonine	CDK1	No	None detected
O95251	88	T	Phosphothreonine	CDK1	No	None detected
O95251	102	S	Phosphoserine	-	No	None detected
O95251	104	T	Phosphothreonine	-	No	None detected
O95251	111	S	Phosphoserine	-	No	None detected
O95251	124	S	Phosphoserine	-	No	None detected
O95251	128	T	Phosphothreonine	-	No	None detected
O95251	158	S	Phosphoserine	-	No	None detected
O95251	162	S	Phosphoserine	-	No	None detected
O95251	164	S	Phosphoserine	-	No	None detected
O95251	178	S	Phosphoserine	-	No	None detected
O95251	199	K	N6-acetyllysine	-	No	None detected
O95251	277	K	N6-acetyllysine	-	No	None detected
O95251	432	K	N6-acetyllysine	autocatalysis	No	None detected
O95251	506	S	Phosphoserine	-	No	None detected

Summary
Symbol	KAT7
Name	lysine acetyltransferase 7
Aliases	HBOA; HBO1; ZC2HC7; histone acetyltransferase binding to ORC1; MYST2; MYST histone acetyltransferase 2; MOZ, ......
Location	17q21.33
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Expression analysis in primary tumor tissue from TCGA > Expression level in cancer cell line from CCLE > Expression level in human normal tissue from HPA > Text mining based expression change

> The Cancer Genome Atlas (TCGA)

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Differential expression analysis for cancers with more than 10 normal samples

Cancer	Full Name	# N	# T	Median (N)	Median (T)	LogFC	Adj. P	Status
BLCA	Bladder urothelial carcinoma	19	408	5.581	5.369	-0.286	0.0486	NS
BRCA	Breast invasive carcinoma	112	1100	5.981	6.018	0.086	0.228	NS
CESC	Cervical and endocervical cancers	3	306	5.951	5.385	NA	NA	NA
COAD	Colon adenocarcinoma	41	459	5.399	5.393	0.005	0.941	NS
ESCA	Esophageal carcinoma	11	185	5.626	5.773	0.028	0.881	NS
GBM	Glioblastoma multiforme	5	166	6.347	6.339	NA	NA	NA
HNSC	Head and Neck squamous cell carcinoma	44	522	5.464	5.194	-0.345	0.000142	NS
KIRC	Kidney renal clear cell carcinoma	72	534	6.153	5.733	-0.46	1.89e-19	NS
KIRP	Kidney renal papillary cell carcinoma	32	291	5.891	5.552	-0.318	6.36e-05	NS
LAML	Acute Myeloid Leukemia	0	173	NA	6.731	NA	NA	NA
LGG	Brain Lower Grade Glioma	0	530	NA	6.68	NA	NA	NA
LIHC	Liver hepatocellular carcinoma	50	373	4.12	4.394	0.328	2.4e-05	NS
LUAD	Lung adenocarcinoma	59	517	5.588	5.686	0.176	0.00937	NS
LUSC	Lung squamous cell carcinoma	51	501	5.501	5.745	0.266	0.000281	NS
OV	Ovarian serous cystadenocarcinoma	0	307	NA	5.946	NA	NA	NA
PAAD	Pancreatic adenocarcinoma	4	179	5.318	5.175	NA	NA	NA
PCPG	Pheochromocytoma and Paraganglioma	3	184	5.162	6.111	NA	NA	NA
PRAD	Prostate adenocarcinoma	52	498	5.968	5.714	-0.293	5.37e-07	NS
READ	Rectum adenocarcinoma	10	167	5.298	5.489	0.173	0.294	NS
SARC	Sarcoma	2	263	5.6	5.406	NA	NA	NA
SKCM	Skin Cutaneous Melanoma	1	472	6.254	6.069	NA	NA	NA
STAD	Stomach adenocarcinoma	35	415	5.613	5.681	-0.036	0.67	NS
TGCT	Testicular Germ Cell Tumors	0	156	NA	7.577	NA	NA	NA
THCA	Thyroid carcinoma	59	509	6.289	6.201	-0.064	0.242	NS
THYM	Thymoma	2	120	5.792	5.856	NA	NA	NA
UCEC	Uterine Corpus Endometrial Carcinoma	35	546	5.925	5.357	-0.552	9.28e-09	NS

> Cancer Cell Line Encyclopedia (CCLE) [ TOP ]
There is no record.

> The Human Protein Atlas (HPA)

[ TOP ]

Tissue	Expression Level (TPM)
Adipose tissue	15.6
Adrenal gland	20.2
Appendix	21.7
Bone marrow	37.6
Breast	23.7
Cerebral cortex	43.5
Cervix, uterine	28.7
Colon	15.1
Duodenum	15.3
Endometrium	38.7
Epididymis	21.5
Esophagus	21.9
Fallopian tube	34
Gallbladder	19.6
Heart muscle	20.9
Kidney	21.7
Liver	6.4
Lung	23.4
Lymph node	22.3
Ovary	28.8
Pancreas	3.2
Parathyroid gland	76.3
Placenta	27.5
Prostate	34.9
Rectum	17.8
Salivary gland	9.6
Seminal vesicle	33.9
Skeletal muscle	12.8
Skin	22.7
Small intestine	16.2
Smooth muscle	31.8
Spleen	25.7
Stomach	12
Testis	106.4
Thyroid gland	53.5
Tonsil	20.5
Urinary bladder	19.3

> Text Mining based Expression

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PMID	Expression	Cancer	Evidence
26072331	Underexpression	Acute Myeloid Leukemia	In the current study, we identified MYST2, a core histone acetyltransferase, to be suppressed in blast cells from AML patients compared with nonmalignant hematopoietic progenitor cells.
22101407	Underexpression	Breast Carcinoma	Reduced amounts of H4K16ac and H4K20me3 correlated with lower levels of MYST2 and SUV420H2 in mesenchymal cells and, along with reduced amounts of histone H3 lysine 9 acetylation (H3K9ac), were found to distinguish epithelial from mesenchymal cells.
21040551	Overexpression	Breast Carcinoma	HBO1 was highly expressed in breast cancer tissues and significantly correlated with estrogen receptor α (ERα) (p<0.001) and progestational hormone (PR) (p=0.002).
19393168	Overexpression	Testicular carcinoma; Ovarian Carcinoma; Breast Carcinoma; Gastric Carcinoma; Bladder Carcinoma	Immunohistochemistry for Hbo1 in 11 primary human tumor types revealed strong Hbo1 protein expression in carcinomas of the testis, ovary, breast, stomach/esophagus, and bladder.
26072331	Underexpression	Acute Myeloid Leukemia	Chromatin-modifying enzymes are frequently altered in acute myeloid leukemia (AML). In the current study, we identified MYST2, a core histone acetyltransferase, to be suppressed in blast cells from AML patients compared with nonmalignant hematopoietic progenitor cells.
22101407	Underexpression	Breast Carcinoma	In this study, we used microarray data from the GEO database to compare gene expression for regulators of metabolism and epigenetic alterations among non-invasive epithelial (MCF-7, MDA-MB-361, and T-47D) and invasive mesenchymal (MDA-MB-231, Hs-578T, and BT-549) breast cancer cell lines. The expression of genes, including GLS1, GFPT2, LDHA, HDAC9, MYST2, and SUV420H2, was assessed using RT-PCR. There was differential expression between epithelial and mesenchymal cell lines. MYST2 and SUV420H2 regulate the levels of the epigenetic biomarkers histone H4 lysine 16 acetylation (H4K16ac) and histone H4 lysine 20 trimethylation (H4K20me3), respectively. Reduced amounts of H4K16ac and H4K20me3 correlated with lower levels of MYST2 and SUV420H2 in mesenchymal cells and, along with reduced amounts of histone H3 lysine 9 acetylation (H3K9ac), were found to distinguish epithelial from mesenchymal cells.
21040551	Overexpression	Breast Carcinoma	HBO1 was highly expressed in breast cancer tissues and significantly correlated with estrogen receptor α (ERα) (p<0.001) and progestational hormone (PR) (p=0.002).
19393168	Overexpression	Testis carcinoma; Ovarian Carcinomaa; Breast Carcinoma; Gastric Carcinoma; esophagus carcinoma; Bladder Carcinoma	Immunohistochemistry for Hbo1 in 11 primary human tumor types revealed strong Hbo1 protein expression in carcinomas of the testis, ovary, breast, stomach/esophagus, and bladder.

Summary
Symbol	KAT7
Name	lysine acetyltransferase 7
Aliases	HBOA; HBO1; ZC2HC7; histone acetyltransferase binding to ORC1; MYST2; MYST histone acetyltransferase 2; MOZ, ......
Location	17q21.33
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Somatic copy number alteration in primary tomur tissue

> The Cancer Genome Atlas (TCGA)

[ TOP ]

Correlation between expression and SCNA as well as percentage of patients in different status.

Cancer	Full Name	# Sample	R	P	% Loss	% Neutral	% Gain	Status
BLCA	Bladder urothelial carcinoma	404	0.579	1.8e-37	7.7	52.5	39.9	Gain
BRCA	Breast invasive carcinoma	1075	0.791	3.89e-231	20.6	48.3	31.2	Neutral
CESC	Cervical and endocervical cancers	292	0.435	6.41e-15	9.2	71.6	19.2	Neutral
COAD	Colon adenocarcinoma	449	0.616	2.94e-48	12.2	67.3	20.5	Neutral
ESCA	Esophageal carcinoma	183	0.546	1.25e-15	9.8	55.7	34.4	Gain
GBM	Glioblastoma multiforme	147	0.209	0.0111	8.8	78.9	12.2	Neutral
HNSC	Head and Neck squamous cell carcinoma	514	0.325	4.27e-14	6.4	75.5	18.1	Neutral
KIRC	Kidney renal clear cell carcinoma	525	0.261	1.19e-09	5.5	88	6.5	Neutral
KIRP	Kidney renal papillary cell carcinoma	288	0.12	0.0419	0.7	31.2	68.1	Gain
LAML	Acute Myeloid Leukemia	166	0.428	8.73e-09	3.6	94	2.4	Neutral
LGG	Brain Lower Grade Glioma	513	0.225	2.56e-07	3.1	92	4.9	Neutral
LIHC	Liver hepatocellular carcinoma	364	0.505	5.36e-25	7.4	62.9	29.7	Neutral
LUAD	Lung adenocarcinoma	512	0.482	3.5e-31	5.3	49.4	45.3	Gain
LUSC	Lung squamous cell carcinoma	498	0.563	5.04e-43	13.9	47.8	38.4	Gain
OV	Ovarian serous cystadenocarcinoma	300	0.706	1.72e-46	53.7	28.3	18	Loss
PAAD	Pancreatic adenocarcinoma	177	0.432	1.87e-09	10.7	74.6	14.7	Neutral
PCPG	Pheochromocytoma and Paraganglioma	162	0.452	1.62e-09	9.9	84.6	5.6	Neutral
PRAD	Prostate adenocarcinoma	491	0.218	1.12e-06	4.3	92.1	3.7	Neutral
READ	Rectum adenocarcinoma	164	0.577	6.35e-16	14.6	62.8	22.6	Neutral
SARC	Sarcoma	255	0.342	2.14e-08	16.1	56.9	27.1	Neutral
SKCM	Skin Cutaneous Melanoma	367	0.558	1.99e-31	14.4	58.3	27.2	Neutral
STAD	Stomach adenocarcinoma	413	0.598	2.15e-41	13.1	64.9	22	Neutral
TGCT	Testicular Germ Cell Tumors	150	0.078	0.34	6.7	54.7	38.7	Gain
THCA	Thyroid carcinoma	497	0.218	9.29e-07	0.2	95.6	4.2	Neutral
THYM	Thymoma	119	0.375	2.62e-05	3.4	89.1	7.6	Neutral
UCEC	Uterine Corpus Endometrial Carcinoma	537	0.499	4.44e-35	15.5	75	9.5	Neutral

Summary
Symbol	KAT7
Name	lysine acetyltransferase 7
Aliases	HBOA; HBO1; ZC2HC7; histone acetyltransferase binding to ORC1; MYST2; MYST histone acetyltransferase 2; MOZ, ......
Location	17q21.33
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Methylation level in the promoter region of CR

> Methylation level in the promoter region of CR

[ TOP ]

Correlation between expression and methylation as well as differential methylation analysis.

Cancer	Full Name	R	P	# N	# T	Delta beta (T vs N)	P value (T vs N)	Status
BLCA	Bladder urothelial carcinoma	-0.17	0.000445	17	408	-0.005	0.0186	NS/NA
BRCA	Breast invasive carcinoma	-0.291	2.71e-18	83	785	-0.009	0.000948	NS/NA
CESC	Cervical and endocervical cancers	-0.269	1.74e-06	3	306	NA	NA	NS/NA
COAD	Colon adenocarcinoma	-0.304	4.09e-08	19	297	0.006	0.0854	NS/NA
ESCA	Esophageal carcinoma	-0.234	0.00103	9	185	NA	NA	NS/NA
GBM	Glioblastoma multiforme	-0.235	0.0592	1	64	NA	NA	NS/NA
HNSC	Head and Neck squamous cell carcinoma	-0.121	0.00478	20	522	-0.003	0.637	NS/NA
KIRC	Kidney renal clear cell carcinoma	-0.139	0.00994	24	319	0.161	1.04e-18	NS/NA
KIRP	Kidney renal papillary cell carcinoma	-0.141	0.0152	23	275	0	0.741	NS/NA
LAML	Acute Myeloid Leukemia	-0.155	0.0441	0	170	NA	NA	NS/NA
LGG	Brain Lower Grade Glioma	-0.009	0.843	0	530	NA	NA	NS/NA
LIHC	Liver hepatocellular carcinoma	-0.336	3.13e-12	41	373	0.004	0.471	NS/NA
LUAD	Lung adenocarcinoma	-0.008	0.864	21	456	-0.002	0.773	NS/NA
LUSC	Lung squamous cell carcinoma	-0.321	2.21e-10	8	370	NA	NA	NS/NA
OV	Ovarian serous cystadenocarcinoma	-0.7	0.0433	0	9	NA	NA	NS/NA
PAAD	Pancreatic adenocarcinoma	-0.122	0.1	4	179	NA	NA	NS/NA
PCPG	Pheochromocytoma and Paraganglioma	-0.388	5.28e-08	3	184	NA	NA	NS/NA
PRAD	Prostate adenocarcinoma	-0.066	0.129	35	498	-0.003	0.349	NS/NA
READ	Rectum adenocarcinoma	-0.247	0.013	2	99	NA	NA	NS/NA
SARC	Sarcoma	-0.34	1.9e-08	0	263	NA	NA	NS/NA
SKCM	Skin Cutaneous Melanoma	-0.299	4.22e-11	1	471	NA	NA	NS/NA
STAD	Stomach adenocarcinoma	-0.346	8.53e-12	0	372	NA	NA	NS/NA
TGCT	Testicular Germ Cell Tumors	-0.415	9.8e-08	0	156	NA	NA	NS/NA
THCA	Thyroid carcinoma	-0.007	0.871	50	509	-0.002	0.315	NS/NA
THYM	Thymoma	-0.166	0.067	2	120	NA	NA	NS/NA
UCEC	Uterine Corpus Endometrial Carcinoma	-0.228	7.5e-07	34	431	0	0.359	NS/NA

Summary
Symbol	KAT7
Name	lysine acetyltransferase 7
Aliases	HBOA; HBO1; ZC2HC7; histone acetyltransferase binding to ORC1; MYST2; MYST histone acetyltransferase 2; MOZ, ......
Location	17q21.33
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Primary tumor tissue from TCGA > Normal tumor tissue from HPA

>The Cancer Genome Atlas (TCGA) [ TOP ]
There is no record.

> The Human Protein Atlas (HPA)

[ TOP ]

Tissue	Level	Level Name
Adrenal gland	2	Medium
Appendix	0	Not detected
Bone marrow	2	Medium
Breast	2	Medium
Bronchus	2	Medium
Caudate	2	Medium
Cerebellum	0	Not detected
Cerebral cortex	2	Medium
Cervix, uterine	2	Medium
Colon	2	Medium
Duodenum	2	Medium
Endometrium	2	Medium
Epididymis	2	Medium
Esophagus	2	Medium
Fallopian tube	2	Medium
Gallbladder	2	Medium
Heart muscle	1	Low
Hippocampus	0	Not detected
Kidney	2	Medium
Liver	0	Not detected
Lung	1	Low
Lymph node	2	Medium
Nasopharynx	2	Medium
Oral mucosa	2	Medium
Ovary	2	Medium
Pancreas	2	Medium
Parathyroid gland	0	Not detected
Placenta	2	Medium
Prostate	0	Not detected
Rectum	2	Medium
Salivary gland	2	Medium
Seminal vesicle	1	Low
Skeletal muscle	2	Medium
Skin	2	Medium
Small intestine	2	Medium
Smooth muscle	1	Low
Soft tissue	2	Medium
Spleen	0	Not detected
Stomach	2	Medium
Testis	3	High
Thyroid gland	2	Medium
Tonsil	2	Medium
Urinary bladder	2	Medium
Vagina	2	Medium

Summary
Symbol	KAT7
Name	lysine acetyltransferase 7
Aliases	HBOA; HBO1; ZC2HC7; histone acetyltransferase binding to ORC1; MYST2; MYST histone acetyltransferase 2; MOZ, ......
Location	17q21.33
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Association between expresson and subtype > Overall survival analysis based on expression > Association between expresson and stage > Association between expresson and grade

> Subtype

[ TOP ]

Association between expresson and subtype.

Cancer	Full Name	# Patients	P Value (Kruskal-Wallis)	Association	Source
BLCA	Bladder urothelial carcinoma	128	0.0274	Significant	24476821
BRCA	Breast invasive carcinoma	521	5.08e-09	Significant	23000897
COAD	Colon adenocarcinoma	149	0.123	NS	22810696
GBM	Glioblastoma multiforme	157	2.15e-10	Significant	26824661
HNSC	Head and Neck squamous cell carcinoma	279	1.38e-11	Significant	25631445
KIRP	Kidney renal papillary cell carcinoma	161	0.026	Significant	26536169
LGG	Brain Lower Grade Glioma	513	8.97e-24	Significant	26824661
LUAD	Lung adenocarcinoma	230	0.00692	Significant	25079552
LUSC	Lung squamous cell carcinoma	178	1.96e-14	Significant	22960745
OV	Ovarian serous cystadenocarcinoma	287	0.144	NS	21720365
PRAD	Prostate adenocarcinoma	333	0.00113	Significant	26544944
READ	Rectum adenocarcinoma	67	0.0687	NS	22810696
SKCM	Skin Cutaneous Melanoma	315	0.451	NS	26091043
STAD	Stomach adenocarcinoma	277	0.00659	Significant	25079317
THCA	Thyroid carcinoma	391	1.02e-11	Significant	25417114
UCEC	Uterine Corpus Endometrial Carcinoma	232	0.536	NS	23636398

> Overall survival

[ TOP ]

Overall survival analysis based on expression.

Cancer	Full Name	# Patients	Hazard Ratio	P Value (Log Rank Test)	Association
BLCA	Bladder urothelial carcinoma	405	1.083	0.715	NS
BRCA	Breast invasive carcinoma	1079	0.925	0.718	NS
CESC	Cervical and endocervical cancers	291	0.886	0.702	NS
COAD	Colon adenocarcinoma	439	0.741	0.276	NS
ESCA	Esophageal carcinoma	184	0.776	0.48	NS
GBM	Glioblastoma multiforme	158	0.639	0.0769	NS
HNSC	Head and Neck squamous cell carcinoma	518	0.945	0.774	NS
KIRC	Kidney renal clear cell carcinoma	531	0.321	3.71e-07	Longer
KIRP	Kidney renal papillary cell carcinoma	287	1.322	0.555	NS
LAML	Acute Myeloid Leukemia	149	0.726	0.265	NS
LGG	Brain Lower Grade Glioma	511	0.381	2.39e-05	Longer
LIHC	Liver hepatocellular carcinoma	365	0.909	0.696	NS
LUAD	Lung adenocarcinoma	502	0.775	0.238	NS
LUSC	Lung squamous cell carcinoma	494	0.739	0.104	NS
OV	Ovarian serous cystadenocarcinoma	303	1.264	0.276	NS
PAAD	Pancreatic adenocarcinoma	177	0.776	0.403	NS
PCPG	Pheochromocytoma and Paraganglioma	179	1.052	0.959	NS
PRAD	Prostate adenocarcinoma	497	0.903	0.894	NS
READ	Rectum adenocarcinoma	159	0.74	0.583	NS
SARC	Sarcoma	259	0.667	0.156	NS
SKCM	Skin Cutaneous Melanoma	459	1.364	0.0964	NS
STAD	Stomach adenocarcinoma	388	0.871	0.57	NS
TGCT	Testicular Germ Cell Tumors	134	594299978.206	0.317	NS
THCA	Thyroid carcinoma	500	1.643	0.381	NS
THYM	Thymoma	119	0.928	0.94	NS
UCEC	Uterine Corpus Endometrial Carcinoma	543	1.438	0.196	NS

> Stage

[ TOP ]

Association between expresson and stage.

Cancer	Full Name	# Patients	R Value (Spearman)	P Value (Spearman)	Association
BLCA	Bladder urothelial carcinoma	406	0.078	0.118	NS
BRCA	Breast invasive carcinoma	1071	0.012	0.687	NS
CESC	Cervical and endocervical cancers	167	0.014	0.854	NS
COAD	Colon adenocarcinoma	445	0.051	0.278	NS
ESCA	Esophageal carcinoma	162	0.036	0.646	NS
HNSC	Head and Neck squamous cell carcinoma	448	-0.003	0.942	NS
KIRC	Kidney renal clear cell carcinoma	531	-0.289	1.06e-11	Lower
KIRP	Kidney renal papillary cell carcinoma	260	0.052	0.407	NS
LIHC	Liver hepatocellular carcinoma	347	0.079	0.139	NS
LUAD	Lung adenocarcinoma	507	-0.025	0.568	NS
LUSC	Lung squamous cell carcinoma	497	0.048	0.283	NS
OV	Ovarian serous cystadenocarcinoma	302	0.002	0.976	NS
PAAD	Pancreatic adenocarcinoma	176	-0.142	0.0605	NS
READ	Rectum adenocarcinoma	156	0.098	0.223	NS
SKCM	Skin Cutaneous Melanoma	410	-0.044	0.376	NS
STAD	Stomach adenocarcinoma	392	0.029	0.561	NS
TGCT	Testicular Germ Cell Tumors	81	0.114	0.309	NS
THCA	Thyroid carcinoma	499	0.005	0.918	NS
UCEC	Uterine Corpus Endometrial Carcinoma	501	0.028	0.529	NS

> Grade

[ TOP ]

Association between expresson and grade.

Cancer	Full Name	# Patients	R Value (Spearman)	P Value (Spearman)	Association
CESC	Cervical and endocervical cancers	272	0.113	0.0637	NS
HNSC	Head and Neck squamous cell carcinoma	498	0.106	0.0179	Higher
KIRC	Kidney renal clear cell carcinoma	525	-0.265	6.86e-10	Lower
LGG	Brain Lower Grade Glioma	514	-0.036	0.42	NS
LIHC	Liver hepatocellular carcinoma	366	0.049	0.351	NS
OV	Ovarian serous cystadenocarcinoma	296	0.019	0.739	NS
PAAD	Pancreatic adenocarcinoma	176	-0.157	0.038	Lower
STAD	Stomach adenocarcinoma	406	-0.02	0.681	NS
UCEC	Uterine Corpus Endometrial Carcinoma	534	0.105	0.0154	Higher

Summary
Symbol	KAT7
Name	lysine acetyltransferase 7
Aliases	HBOA; HBO1; ZC2HC7; histone acetyltransferase binding to ORC1; MYST2; MYST histone acetyltransferase 2; MOZ, ......
Location	17q21.33
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Targets inferred by reverse engineering method > Targets identified by ChIP-seq data

> Targets inferred by reverse engineering method [ TOP ]

> Targets identified by ChIP-seq data [ TOP ]

Summary
Symbol	KAT7
Name	lysine acetyltransferase 7
Aliases	HBOA; HBO1; ZC2HC7; histone acetyltransferase binding to ORC1; MYST2; MYST histone acetyltransferase 2; MOZ, ......
Location	17q21.33
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Drugs from DrugBank database

> Drugs from DrugBank database [ TOP ]
There is no record for KAT7.

Summary
Symbol	KAT7
Name	lysine acetyltransferase 7
Aliases	HBOA; HBO1; ZC2HC7; histone acetyltransferase binding to ORC1; MYST2; MYST histone acetyltransferase 2; MOZ, ......
Location	17q21.33
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Protein-Protein Interaction Network > miRNA Regulatory Relationship > Interactions from Text Mining

> Protein-Protein Interaction Network [ TOP ]

> miRNA Regulatory Relationship [ TOP ]

> Interactions from Text Mining

[ TOP ]

PMID	Cancer	Hierarchy	Gene	Relation to CR	Evidence
21040551	Breast Carcinoma	upstream	E2; ERα	Positive regulation	HBO1 protein level also correlated positively with histology grade in ERα positive tumors (p=0.016) rather than ERα negative tumors. 17β-estradiol (E2) could upregulate HBO1 gene expression which was significantly inhibited by ICI 182,780 or ERα RNAi. E2-increased HBO1 protein expression was significantly suppressed by treatment with inhibitor of MEK1/2 (U0126) in T47 D and MCF-7 cells. HBO1 was an important downstream molecule of ERα, and ERK1/2 signaling pathway may involved in the expression of HBO1 increased by E2.
22101407	Breast Carcinoma	partner	H4K16ac; H4K20me3		Reduced amounts of H4K16ac and H4K20me3 correlated with lower levels of MYST2 and SUV420H2 in mesenchymal cells and, along with reduced amounts of histone H3 lysine 9 acetylation (H3K9ac), were found to distinguish epithelial from mesenchymal cells.
21040551	Breast Carcinoma	upstream	E2; ICI 182; ICI 780; ERα	positive regulation; negative regulation; negative regulation; negative regulation	17β-estradiol (E2) could upregulate HBO1 gene expression which was significantly inhibited by ICI 182,780 or ERα RNAi.