CR2Cancer

Summary
Symbol	SUZ12
Name	SUZ12 polycomb repressive complex 2 subunit
Aliases	JJAZ1; KIAA0160; CHET9; suppressor of zeste 12 homolog (Drosophila); chET 9 protein; chromatin precipitated ......
Location	17q11.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Domain, Function and Classification > Gene Ontology > KEGG and Reactome Pathway

> Domain, Function and Classification

[ TOP ]

Domain

PF09733 VEFS-Box of polycomb protein

Function

Polycomb group (PcG) protein. Component of the PRC2/EED-EZH2 complex, which methylates 'Lys-9' (H3K9me) and 'Lys-27' (H3K27me) of histone H3, leading to transcriptional repression of the affected target gene. The PRC2/EED-EZH2 complex may also serve as a recruiting platform for DNA methyltransferases, thereby linking two epigenetic repression systems. Genes repressed by the PRC2/EED-EZH2 complex include HOXC8, HOXA9, MYT1 and CDKN2A.

Classification

Class	Modification	Substrate	Product	PubMed
Histone modification write cofactor, Histone modification write cofactor, Polycomb group (PcG) protein	Histone methylation, Histone ubiquitination, #	DNA motif	#	15385962

> Gene Ontology [ TOP ]
Biological Process	GO:0006479 protein methylation GO:0008213 protein alkylation GO:0016570 histone modification GO:0016571 histone methylation GO:0016574 histone ubiquitination GO:0032259 methylation GO:0040029 regulation of gene expression, epigenetic GO:0043414 macromolecule methylation GO:0045814 negative regulation of gene expression, epigenetic
Molecular Function	GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding GO:0001046 core promoter sequence-specific DNA binding GO:0001047 core promoter binding GO:0003682 chromatin binding GO:0008168 methyltransferase activity GO:0008276 protein methyltransferase activity GO:0016741 transferase activity, transferring one-carbon groups GO:0031490 chromatin DNA binding GO:0035064 methylated histone binding GO:0042054 histone methyltransferase activity GO:0042393 histone binding GO:0043566 structure-specific DNA binding
Cellular Component	GO:0000785 chromatin GO:0000790 nuclear chromatin GO:0000792 heterochromatin GO:0000803 sex chromosome GO:0001739 sex chromatin GO:0005720 nuclear heterochromatin GO:0031519 PcG protein complex GO:0032993 protein-DNA complex GO:0034708 methyltransferase complex GO:0035097 histone methyltransferase complex GO:0035098 ESC/E(Z) complex GO:0044454 nuclear chromosome part

> KEGG and Reactome Pathway [ TOP ]
KEGG	-
Reactome	R-HSA-5619507: Activation of HOX genes during differentiation R-HSA-5617472: Activation of anterior HOX genes in hindbrain development during early embryogenesis R-HSA-2559583: Cellular Senescence R-HSA-2262752: Cellular responses to stress R-HSA-3247509: Chromatin modifying enzymes R-HSA-4839726: Chromatin organization R-HSA-1266738: Developmental Biology R-HSA-212165: Epigenetic regulation of gene expression R-HSA-74160: Gene Expression R-HSA-2559580: Oxidative Stress Induced Senescence R-HSA-3214841: PKMTs methylate histone lysines R-HSA-212300: PRC2 methylates histones and DNA

> KEGG and Reactome Pathway

[ TOP ]

KEGG

Reactome

R-HSA-5619507: Activation of HOX genes during differentiation
R-HSA-5617472: Activation of anterior HOX genes in hindbrain development during early embryogenesis
R-HSA-2559583: Cellular Senescence
R-HSA-2262752: Cellular responses to stress
R-HSA-3247509: Chromatin modifying enzymes
R-HSA-4839726: Chromatin organization
R-HSA-1266738: Developmental Biology
R-HSA-212165: Epigenetic regulation of gene expression
R-HSA-74160: Gene Expression
R-HSA-2559580: Oxidative Stress Induced Senescence
R-HSA-3214841: PKMTs methylate histone lysines
R-HSA-212300: PRC2 methylates histones and DNA

Summary
Symbol	SUZ12
Name	SUZ12 polycomb repressive complex 2 subunit
Aliases	JJAZ1; KIAA0160; CHET9; suppressor of zeste 12 homolog (Drosophila); chET 9 protein; chromatin precipitated ......
Location	17q11.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Mutation landscape in primary tumor tissue from TCGA > Mutation landscape in cancer cell line from CCLE > All mutations from COSMIC database V81 > Variations from text mining

> The Cancer Genome Atlas (TCGA) [ TOP ]

> Cancer Cell Line Encyclopedia (CCLE) [ TOP ]

> Catalogue of Somatic Mutations in Cancer (COSMIC)

[ TOP ]

COSMIC ID	CDS change	AA change	Mutation Type	Anatomical Site
COSM977574	c.2044C>T	p.R682C	Substitution - Missense	Endometrium
COSM977560	c.1038C>T	p.F346F	Substitution - coding silent	Endometrium
COSM5751495	c.115G>AG	p.G39fs*44	Complex - frameshift	Haematopoietic_and_lymphoid_tissue
COSM4950502	c.1148A>G	p.E383G	Substitution - Missense	Liver
COSM705618	c.1375A>G	p.K459E	Substitution - Missense	Lung
COSM3819258	c.955A>C	p.M319L	Substitution - Missense	Breast
COSM4606555	c.1692_1704del13	p.Y565fs*13	Deletion - Frameshift	Haematopoietic_and_lymphoid_tissue
COSM4731010	c.1183A>G	p.K395E	Substitution - Missense	Large_intestine
COSM3515945	c.698C>T	p.S233F	Substitution - Missense	Skin
COSM301320	c.856C>T	p.R286*	Substitution - Nonsense	Large_intestine
COSM5751666	c.1255_1256insT	p.P419fs*3	Insertion - Frameshift	Haematopoietic_and_lymphoid_tissue
COSM977562	c.1062G>A	p.T354T	Substitution - coding silent	Endometrium
COSM303325	c.1794+1G>C	p.?	Unknown	Central_nervous_system
COSM977568	c.1323A>C	p.Q441H	Substitution - Missense	Endometrium
COSM4806245	c.1824A>G	p.E608E	Substitution - coding silent	Liver
COSM977558	c.974G>A	p.C325Y	Substitution - Missense	Endometrium
COSM1228053	c.1078C>T	p.R360C	Substitution - Missense	Large_intestine
COSM1228054	c.1926T>G	p.N642K	Substitution - Missense	Large_intestine
COSM4568246	c.1047T>A	p.F349L	Substitution - Missense	Skin
COSM1679709	c.1702A>G	p.S568G	Substitution - Missense	Large_intestine
COSM4958522	c.1202-1G>A	p.?	Unknown	Liver
COSM4428170	c.1993G>A	p.D665N	Substitution - Missense	Oesophagus
COSM4950043	c.1859_1860delAT	p.H620fs*9	Deletion - Frameshift	Liver
COSM3889508	c.2043C>T	p.L681L	Substitution - coding silent	Skin
COSM977543	c.426G>T	p.E142D	Substitution - Missense	Endometrium
COSM4994704	c.1486G>A	p.D496N	Substitution - Missense	Large_intestine
COSM4065383	c.857G>A	p.R286Q	Substitution - Missense	Stomach
COSM977545	c.480G>A	p.T160T	Substitution - coding silent	Endometrium
COSM3515949	c.868G>A	p.D290N	Substitution - Missense	Skin
COSM3180216	c.1552G>A	p.G518R	Substitution - Missense	Large_intestine
COSM4447258	c.1202-3C>A	p.?	Unknown	Skin
COSM3728338	c.1377delA	p.K459fs*29	Deletion - Frameshift	Haematopoietic_and_lymphoid_tissue
COSM4619449	c.1079G>A	p.R360H	Substitution - Missense	Large_intestine
COSM977550	c.546T>C	p.V182V	Substitution - coding silent	Endometrium
COSM1749950	c.992G>A	p.R331K	Substitution - Missense	Urinary_tract
COSM977540	c.302G>A	p.R101Q	Substitution - Missense	Endometrium
COSM5900622	c.1444C>T	p.P482S	Substitution - Missense	Skin
COSM5900356	c.1699C>T	p.H567Y	Substitution - Missense	Skin
COSM306089	c.1105_1106insA	p.S369fs*12	Insertion - Frameshift	Haematopoietic_and_lymphoid_tissue
COSM977545	c.480G>A	p.T160T	Substitution - coding silent	Endometrium
COSM3421403	c.1039G>A	p.E347K	Substitution - Missense	Large_intestine
COSM5751617	c.700_701insG	p.S234fs*2	Insertion - Frameshift	Haematopoietic_and_lymphoid_tissue
COSM705619	c.1373G>A	p.R458H	Substitution - Missense	Lung
COSM5972136	c.140G>C	p.G47A	Substitution - Missense	Upper_aerodigestive_tract
COSM3180208	c.1146_1147delAG	p.L385fs*10	Deletion - Frameshift	Haematopoietic_and_lymphoid_tissue
COSM4572668	c.825T>A	p.D275E	Substitution - Missense	Skin
COSM472554	c.1430A>C	p.N477T	Substitution - Missense	Kidney
COSM1382257	c.1412A>G	p.H471R	Substitution - Missense	Large_intestine
COSM1664407	c.1764T>G	p.D588E	Substitution - Missense	Kidney
COSM472553	c.1013T>A	p.L338H	Substitution - Missense	Kidney
COSM5755008	c.598A>T	p.S200C	Substitution - Missense	Large_intestine
COSM5751710	c.998C>AC	p.T333fs*7	Complex - frameshift	Haematopoietic_and_lymphoid_tissue
COSM5916629	c.1875-8T>A	p.?	Unknown	Skin
COSM4552472	c.55G>A	p.G19R	Substitution - Missense	Skin
COSM1382258	c.1950G>T	p.K650N	Substitution - Missense	Large_intestine
COSM4806245	c.1824A>G	p.E608E	Substitution - coding silent	Liver
COSM4731012	c.2098G>T	p.E700*	Substitution - Nonsense	Large_intestine
COSM5762947	c.751C>G	p.L251V	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM1324051	c.1742T>A	p.V581E	Substitution - Missense	Ovary
COSM3819259	c.2073G>A	p.G691G	Substitution - coding silent	Breast
COSM705621	c.995C>T	p.A332V	Substitution - Missense	Lung
COSM306089	c.1105_1106insA	p.S369fs*12	Insertion - Frameshift	Haematopoietic_and_lymphoid_tissue
COSM3180223	c.1886A>T	p.D629V	Substitution - Missense	Upper_aerodigestive_tract
COSM228660	c.1284A>G	p.I428M	Substitution - Missense	Skin
COSM158733	c.488G>A	p.G163D	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM4169226	c.283C>A	p.Q95K	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM1228052	c.767G>A	p.R256H	Substitution - Missense	Large_intestine
COSM4745721	c.1814A>T	p.D605V	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM3680133	c.153T>G	p.S51R	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM3515944	c.681C>T	p.F227F	Substitution - coding silent	Skin
COSM1684498	c.2148_2154delCTCAAAA	p.N716fs*>22	Deletion - Frameshift	Central_nervous_system
COSM472551	c.667A>T	p.K223*	Substitution - Nonsense	Kidney
COSM5913950	c.650C>T	p.P217L	Substitution - Missense	Skin
COSM4751956	c.212T>C	p.V71A	Substitution - Missense	Stomach
COSM1302624	c.795G>A	p.M265I	Substitution - Missense	Urinary_tract
COSM705620	c.1090G>T	p.E364*	Substitution - Nonsense	Lung
COSM5751554	c.1805_1806insG	p.F603fs*3	Insertion - Frameshift	Haematopoietic_and_lymphoid_tissue
COSM977576	c.2173G>T	p.D725Y	Substitution - Missense	Endometrium
COSM436342	c.285G>C	p.Q95H	Substitution - Missense	Breast
COSM3723757	c.1648G>A	p.E550K	Substitution - Missense	Upper_aerodigestive_tract
COSM1659307	c.1620G>T	p.M540I	Substitution - Missense	Kidney
COSM158733	c.488G>A	p.G163D	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM184333	c.308G>A	p.R103Q	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM436343	c.343_346delCTTA	p.Y117fs*24	Deletion - Frameshift	Breast
COSM3402757	c.1261G>A	p.E421K	Substitution - Missense	Central_nervous_system
COSM436343	c.343_346delCTTA	p.Y117fs*24	Deletion - Frameshift	Endometrium
COSM4524368	c.1268G>A	p.R423Q	Substitution - Missense	Large_intestine
COSM977566	c.1316G>T	p.R439M	Substitution - Missense	Endometrium
COSM4065388	c.1723C>T	p.R575C	Substitution - Missense	Stomach
COSM1318519	c.921_922delCT	p.L308fs*8	Deletion - Frameshift	Haematopoietic_and_lymphoid_tissue
COSM1479429	c.1585C>G	p.L529V	Substitution - Missense	Breast
COSM1302627	c.1811C>G	p.S604C	Substitution - Missense	Urinary_tract
COSM4950452	c.1122_1147del26	p.K375fs*12	Deletion - Frameshift	Liver
COSM4788404	c.1018G>A	p.G340R	Substitution - Missense	Liver
COSM5070178	c.1098T>C	p.N366N	Substitution - coding silent	Large_intestine
COSM5462630	c.1018G>T	p.G340W	Substitution - Missense	Large_intestine
COSM3720499	c.372_375delAACA	p.N126fs*15	Deletion - Frameshift	Haematopoietic_and_lymphoid_tissue
COSM1749950	c.992G>A	p.R331K	Substitution - Missense	Urinary_tract
COSM1302626	c.1801G>C	p.E601Q	Substitution - Missense	Urinary_tract
COSM301320	c.856C>T	p.R286*	Substitution - Nonsense	Central_nervous_system
COSM977547	c.504T>C	p.N168N	Substitution - coding silent	Endometrium
COSM4391032	c.432G>C	p.M144I	Substitution - Missense	Breast
COSM4775117	c.820A>C	p.I274L	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM4950452	c.1122_1147del26	p.K375fs*12	Deletion - Frameshift	Liver
COSM977572	c.2013A>G	p.I671M	Substitution - Missense	Endometrium
COSM3958191	c.824-1G>T	p.?	Unknown	Lung
COSM5751195	c.787_788insT	p.N263fs*5	Insertion - Frameshift	Haematopoietic_and_lymphoid_tissue
COSM436344	c.1147G>A	p.E383K	Substitution - Missense	Breast
COSM4826795	c.657C>G	p.L219L	Substitution - coding silent	Cervix
COSM4065383	c.857G>A	p.R286Q	Substitution - Missense	Large_intestine
COSM301320	c.856C>T	p.R286*	Substitution - Nonsense	Haematopoietic_and_lymphoid_tissue
COSM5662183	c.1658A>C	p.Q553P	Substitution - Missense	Soft_tissue
COSM3515943	c.619C>T	p.P207S	Substitution - Missense	Skin
COSM1228053	c.1078C>T	p.R360C	Substitution - Missense	Skin
COSM5078794	c.406G>T	p.D136Y	Substitution - Missense	Large_intestine
COSM164706	c.2192C>G	p.S731*	Substitution - Nonsense	Breast
COSM3515956	c.2166G>A	p.L722L	Substitution - coding silent	Skin
COSM5513949	c.823+5delT	p.?	Unknown	Biliary_tract
COSM4524368	c.1268G>A	p.R423Q	Substitution - Missense	Skin
COSM4950032	c.1862T>A	p.V621D	Substitution - Missense	Liver
COSM5897964	c.1351C>T	p.P451S	Substitution - Missense	Skin
COSM4950502	c.1148A>G	p.E383G	Substitution - Missense	Liver
COSM4885607	c.1156C>A	p.H386N	Substitution - Missense	Upper_aerodigestive_tract
COSM4065387	c.994G>A	p.A332T	Substitution - Missense	Stomach
COSM4950032	c.1862T>A	p.V621D	Substitution - Missense	Liver
COSM164705	c.338G>A	p.R113K	Substitution - Missense	Breast
COSM1679709	c.1702A>G	p.S568G	Substitution - Missense	Large_intestine
COSM1679709	c.1702A>G	p.S568G	Substitution - Missense	Large_intestine
COSM303325	c.1794+1G>C	p.?	Unknown	Central_nervous_system
COSM1679709	c.1702A>G	p.S568G	Substitution - Missense	Large_intestine
COSM977564	c.1295T>G	p.F432C	Substitution - Missense	Endometrium
COSM4950043	c.1859_1860delAT	p.H620fs*9	Deletion - Frameshift	Liver
COSM977570	c.1993G>T	p.D665Y	Substitution - Missense	Endometrium
COSM1720599	c.161_163delCCT	p.S59delS	Deletion - In frame	Skin
COSM4807483	c.1829A>G	p.E610G	Substitution - Missense	Pancreas
COSM5811055	c.592-2A>T	p.?	Unknown	Liver
COSM5636701	c.2070G>T	p.K690N	Substitution - Missense	Oesophagus
COSM5055362	c.1722C>A	p.L574L	Substitution - coding silent	Stomach
COSM4788404	c.1018G>A	p.G340R	Substitution - Missense	Liver
COSM4958522	c.1202-1G>A	p.?	Unknown	Liver
COSM1684498	c.2148_2154delCTCAAAA	p.N716fs*>22	Deletion - Frameshift	Lung
COSM258115	c.920G>A	p.R307H	Substitution - Missense	Large_intestine
COSM1382256	c.427A>G	p.K143E	Substitution - Missense	Large_intestine
COSM4169226	c.283C>A	p.Q95K	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM3983366	c.184G>C	p.A62P	Substitution - Missense	Ovary
COSM5751611	c.1582_1583delAT	p.I528fs*14	Deletion - Frameshift	Haematopoietic_and_lymphoid_tissue
COSM5925951	c.1917T>A	p.F639L	Substitution - Missense	Skin
COSM3180213	c.1522C>T	p.R508C	Substitution - Missense	Large_intestine
COSM977553	c.646A>C	p.N216H	Substitution - Missense	Endometrium
COSM4731011	c.2087_2088insA	p.A697fs*7	Insertion - Frameshift	Large_intestine
COSM5755008	c.598A>T	p.S200C	Substitution - Missense	Large_intestine
COSM5759405	c.1771T>C	p.W591R	Substitution - Missense	Bone
COSM3515955	c.1875-1G>T	p.?	Unknown	Skin
COSM158733	c.488G>A	p.G163D	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM4531793	c.1825G>A	p.G609R	Substitution - Missense	Skin
COSM301319	c.301C>T	p.R101*	Substitution - Nonsense	Large_intestine
COSM301319	c.301C>T	p.R101*	Substitution - Nonsense	Prostate
COSM4774846	c.1738G>T	p.E580*	Substitution - Nonsense	Haematopoietic_and_lymphoid_tissue
COSM1302625	c.1129C>T	p.L377F	Substitution - Missense	Urinary_tract

> Text Mining based Variations

[ TOP ]

PMID	Variation	Cancer	Evidence
27738815	mutation	Stromal Neoplasm	Low grade stromal neoplasms frequently show gene fusions, such as JAZF1/SUZ12.
27738815	Mutation	uterine neoplasm	Low grade stromal neoplasms frequently show gene fusions, such as JAZF1/SUZ12
27142911	Mutation	Endometrial Stromal Sarcoma	The positive rate of JAZF1-SUZ12 fusion gene was 30.8% (12/39) in low-grade ESS.
26990975	Mutation	Malignant peripheral nerve sheath tumor	Furthermore, both SUZ12 and EED mutations in MPNSTs were associated with loss of H3K27 tri-methylation, a downstream target of PRC2.
26880370	Mutation	HTLV-I-induced acute adult T-cell Leukemia	Here we used whole genome next generation sequencing (NGS) of uncultured freshly isolated ATL samples and identified the presence of mutations in SUZ12, DNMT1, DNMT3A, DNMT3B, TET1, TET2, IDH1, IDH2, MLL, MLL2, MLL3 and MLL4.
26879382	Mutation	Endometrial Carcinoma; stromal sarcoma	To date the JAZF1/SUZ12 gene fusion is by far the most frequent and seems to be the cytogenetic hallmark of ESN and LG-ESS.
26442588	Mutation (gain of function); Mutation (loss of function)	Hepatocellular Carcinoma	Furthermore, gain or loss of function in polycomb repressive complex 2 (PRC2) components, including EZH2, SUZ12, and EED, elucidated epigenetic control of H3K27me3-arbitrated PAK6 down-regulation in hepatoma cells.
26429873	Mutation	Endometrioid Stromal Sarcoma	All three LG-ESSs exhibited either one of JAZF1-SUZ12, JAZF1-PHF1 and MEAF6-PHF1 fusions, whereas the two UUSs did not.
25355621	Mutation	Endometrial Stromal Sarcoma	Low-grade ESSs frequently contain chromosomal rearrangements that result in JAZF1-SUZ12 fusion or equivalent genetic fusions.
25305755	Mutation	malignant peripheral nerve sheath tumor	Sixteen MPNSTs but none of the neurofibromas tested were found to have somatic mutations in SUZ12, implicating it as having a central role in malignant transformation.
25299308	Mutation	Endometrial Stromal Nodule; Endometrial Stromal Sarcoma	Specifically, the JAZF1-SUZ12 (formerly JAZF1-JJAZ1) fusion identifies a large proportion of ESN and LG-ESSs, whereas the YWHAE-FAM22 translocation identifies HG-ESSs.
25244093	Mutation	myeloid neoplasm	In addition to mutations in PIGA, mutations were found in genes known to be involved in myeloid neoplasm pathogenesis, including TET2, SUZ12, U2AF1, and JAK2.
24750188	Mutation	Endometrial stromal tumor	Here we report an unusual case of ESTs. Sudden colonic perforation occurred to the patient, and emergency surgery was performed. Pathological findings suggested metastatic ESS. Thorough medical examination of the genital organs detected a 1cm-sized well-demarcated uterine tumor. Microscopically, the tumor lacked infiltrative features, conforming to the definition of ESN. Both lesions demonstrated identical cytology and shared JAZF1-SUZ12 gene fusion.
23486531	Mutation	Myeloid Neoplasm	When we assessed the mutational status in myeloid malignancies (N=469 cases examined), we found EZH2 and EED/SUZ12 mutations in 8% and 3.3% of cases, respectively.
23211293	Mutation	Uterine Neoplasm; Endometrial Stromal Nodule; Endometrial Stromal Sarcoma	A tissue microarray was prepared, and FISH analysis was performed using break-apart and fusion probes for JAZF1, SUZ12, EPC1, and PHF1 genes. FISH was successful in 22 cases, and rearrangements involving JAZF1, SUZ12, EPC1, and PHF1 genes were detected in 10 of the 22 (45%) uterine tumors, including 2 of the 3 ESNs and 8 of 12 ESSs.
23159154	Mutation	Endometrioid Stromal Sarcoma	We studied a series of 6 YWHAE-FAM22 endometrial stromal sarcomas, 7 JAZF-SUZ12 endometrial stromal sarcomas, 3 JAZF1-PHF1/EPC1-PHF1 endometrial stromal sarcomas, 6 undifferentiated endometrial sarcomas, 4 uterine leiomyosarcomas, and 4 uterine adenosarcomas.
22489043	Mutation	myeloproliferative neoplasm	Mutations in the other genes were rare (CBL, DNMT3A, IDH2, MPL, SF3B1, SUZ12, NF1) or absent (IDH1).
22371884	Mutation	Acute Myeloid Leukemia	The other 9 mutations were only apparent in the AML cells and affected known AML-associated genes (RUNX1 and ASXL1) and chromatin remodelers (SUZ12 and EP300).
22308277	Mutation	Myelodysplastic Syndrome; Myeloproliferative Neoplasm	An unexpected revelation of cancer genome studies has been frequent abnormality in genes for factors that modify chromatin, underscored in this issue of Blood by reports from Score et al and Kroeze et al of inactivating mutations and chromosome loss in SUZ12, EED and JARID2 in myelodysplastic syndrome (MDS) and myeloproliferative disease (MPD).
22237151	Mutation (loss of function); copy number loss	T Acute Lymphoblastic Leukemia	In this study we report the presence of loss-of-function mutations and deletions of the EZH2 and SUZ12 genes, which encode crucial components of the Polycomb repressive complex 2 (PRC2), in 25% of T-ALLs.
22237106	Mutation	T Acute Lymphoblastic Leukemia	ETP ALL was characterized by activating mutations in genes regulating cytokine receptor and RAS signalling (67% of cases; NRAS, KRAS, FLT3, IL7R, JAK3, JAK1, SH2B3 and BRAF), inactivating lesions disrupting haematopoietic development (58%; GATA3, ETV6, RUNX1, IKZF1 and EP300) and histone-modifying genes
22053108	Mutation	myelodysplastic syndrome; Myeloproliferative Neoplasm	SUZ12 mutations were identified in 1 of 2 patients with myelodysplastic syndrome/myeloproliferative neoplasms with 17q acquired uniparental disomy and in 2 of 2 myelofibrosis cases with focal 17q11 deletions.
21836477	Mutation	Endometrial Stromal Nodule; Endometrial Stromal Sarcoma	Rearrangements were detected in 42 of 78 (54%) uterine ESTs, with JAZF1-SUZ12 fusion found in 50% of ESNs and in 33% of ESSs and JAZF1-PHF1 and EPC1-PHF1 fusions found in 1% and <1% of ESSs, respectively.
21480320	Mutation	Endometrioid Stromal Sarcoma	In one of the 6 extrauterine endometrial stromal sarcoma cases, JAZF1-JJAZ1 fusion transcripts were detected by reverse transcriptase-polymerase chain reaction.
26838781	Mutation	Endometrial Stromal Tumor	Genomic analysis techniques have revealed important genetic aberrations such as the t(7;17) translocation, resulting in JAZF1-JJAZ1 gene fusion, characteristic of endometrial stromal tumors.
18580489	Mutation	Endometrial Stromal Sarcoma; undifferentiated Endometrial Carcinomaetrial sarcoma	JAZF1-JJAZ1 fusion transcript was detected in 6 (50%) out of 12 ESS-LG and in 1 (33%) of 3 UES-U, whereas it was not detected in any of the cases of UES-P.
18264096	Mutation	Endometrial Carcinoma	Loci on chromosome 10 include MSMB, which encodes beta-microseminoprotein, a primary constituent of semen and a proposed prostate cancer biomarker, and CTBP2, a gene with antiapoptotic activity; the locus on chromosome 7 is at JAZF1, a transcriptional repressor that is fused by chromosome translocation to SUZ12 in endometrial cancer.
17365822	Mutation	Endometrial Stromal Nodule; Endometrial Stromal Sarcoma	ESS and ESN share the fusion gene JAZF1/JJAZ1 caused by a t(7;17)(p15;q21) translocation, whereas UES lacks a distinctive molecular alteration so far.
17197920	Mutation	Endometrioid Stromal Sarcoma; Endometrial Stromal Nodule	Overall, evidence for the JAZF1-JJAZ1 fusion was found in 60% of endometrial stromal neoplasms analyzed (8/16 ESS and 4/4 stromal nodules).
16049311	Mutation	Endometrioid Stromal Sarcoma	Hitherto only 31 cases, described by three different research groups, have shown JAZF1/JJAZ1 fusion in approximately 50% of all analyzed low-grade ESSs whereas it is less frequent in UESs.
15043312	Mutation	Endometrial stromal tumor	JAZF1-JJAZ1 gene fusion transcripts were detected in five (33%) of 15 ESTs, including three of eight primary uterine, one of four metastatic, one of one extrauterine, and none of two recurrent cases. Most ESTs of classic histology showed evidence of JAZF1-JJAZ1 fusion (4 of 5 cases), whereas only one mixed smooth muscle ESN of 10 variant cases was positive.
12850374	Mutation	Endometrioid Stromal Sarcoma	We report three additional cases of ESS with abnormal karyotypes, whose interpretation was based on the combined analysis by conventional cytogenetics and cross-species color banding FISH (RxFISH). The combination of G-banding and RxFISH in every case gave additional information beyond that obtained by either technique alone, determining the identity of even complex inter- as well as intrachromosomal rearrangements. In one of the three tumors, a t(7;17) was seen; molecular genetic studies identified the JAZF1/JJAZ1 fusion gene in this case.
11371647	Mutation	Endometrial Carcinomaetrial stromal tumor	Analyses of tumor RNA indicate that a JAZF1/JJAZ1 fusion is present in all types of endometrial stromal tumors; however, the fusion appears to be rarer among endometrial stromal sarcomas that would be considered high-grade according to certain classification schemes.

Summary
Symbol	SUZ12
Name	SUZ12 polycomb repressive complex 2 subunit
Aliases	JJAZ1; KIAA0160; CHET9; suppressor of zeste 12 homolog (Drosophila); chET 9 protein; chromatin precipitated ......
Location	17q11.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Post-translational modification (PTM)

> Post-translational modification (PTM)

[ TOP ]

Filter By:

Uniprot ID	Position	Amino Acid	Description	Upstream Enzyme	Affected By Mutation	Amino Acid Sequence Variant
Q15022	541	S	Phosphoserine	-	No	None detected
Q15022	546	S	Phosphoserine	-	No	None detected
Q15022	583	S	Phosphoserine	-	Yes	p.S583I (cancer: BLCA)
Q15022	726	S	Phosphoserine	-	No	None detected

Summary
Symbol	SUZ12
Name	SUZ12 polycomb repressive complex 2 subunit
Aliases	JJAZ1; KIAA0160; CHET9; suppressor of zeste 12 homolog (Drosophila); chET 9 protein; chromatin precipitated ......
Location	17q11.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Expression analysis in primary tumor tissue from TCGA > Expression level in cancer cell line from CCLE > Expression level in human normal tissue from HPA > Text mining based expression change

> The Cancer Genome Atlas (TCGA)

[ TOP ]

Differential expression analysis for cancers with more than 10 normal samples

Cancer	Full Name	# N	# T	Median (N)	Median (T)	LogFC	Adj. P	Status
BLCA	Bladder urothelial carcinoma	19	408	5.431	5.668	0.373	0.0184	NS
BRCA	Breast invasive carcinoma	112	1100	5.521	5.766	0.273	2.42e-05	NS
CESC	Cervical and endocervical cancers	3	306	5.33	5.991	NA	NA	NA
COAD	Colon adenocarcinoma	41	459	5.277	5.698	0.282	0.0252	NS
ESCA	Esophageal carcinoma	11	185	5.48	6.076	0.517	0.00558	NS
GBM	Glioblastoma multiforme	5	166	4.808	5.364	NA	NA	NA
HNSC	Head and Neck squamous cell carcinoma	44	522	5.013	5.388	0.361	0.000335	NS
KIRC	Kidney renal clear cell carcinoma	72	534	5.682	5.308	-0.387	3.63e-12	NS
KIRP	Kidney renal papillary cell carcinoma	32	291	5.357	5.194	-0.171	0.0617	NS
LAML	Acute Myeloid Leukemia	0	173	NA	6.718	NA	NA	NA
LGG	Brain Lower Grade Glioma	0	530	NA	5.247	NA	NA	NA
LIHC	Liver hepatocellular carcinoma	50	373	4.441	4.664	0.246	0.00982	NS
LUAD	Lung adenocarcinoma	59	517	5.242	5.647	0.424	2.08e-08	NS
LUSC	Lung squamous cell carcinoma	51	501	5.131	5.897	0.654	7.94e-13	Over
OV	Ovarian serous cystadenocarcinoma	0	307	NA	5.223	NA	NA	NA
PAAD	Pancreatic adenocarcinoma	4	179	5.033	5.15	NA	NA	NA
PCPG	Pheochromocytoma and Paraganglioma	3	184	4.944	4.685	NA	NA	NA
PRAD	Prostate adenocarcinoma	52	498	5.451	5.292	-0.077	0.346	NS
READ	Rectum adenocarcinoma	10	167	5.361	5.508	-0.03	0.93	NS
SARC	Sarcoma	2	263	5.032	5.277	NA	NA	NA
SKCM	Skin Cutaneous Melanoma	1	472	5.778	5.381	NA	NA	NA
STAD	Stomach adenocarcinoma	35	415	5.226	5.923	0.649	5.11e-11	Over
TGCT	Testicular Germ Cell Tumors	0	156	NA	5.763	NA	NA	NA
THCA	Thyroid carcinoma	59	509	5.563	5.397	-0.107	0.0616	NS
THYM	Thymoma	2	120	6.174	5.779	NA	NA	NA
UCEC	Uterine Corpus Endometrial Carcinoma	35	546	5.232	5.283	-0.059	0.713	NS

> Cancer Cell Line Encyclopedia (CCLE)

[ TOP ]

Tissue	Cell Line	Expression Level (Microarray)
Autonomic ganglia	CHP126	10.6
Autonomic ganglia	CHP212	10.5
Autonomic ganglia	IMR32	10.3
Autonomic ganglia	KELLY	10.8
Autonomic ganglia	KPNRTBM1	10.3
Autonomic ganglia	KPNSI9S	9.6
Autonomic ganglia	KPNYN	9.7
Autonomic ganglia	MHHNB11	10.1
Autonomic ganglia	NB1	10.2
Autonomic ganglia	NH6	10.3
Autonomic ganglia	SHSY5Y	10.5
Autonomic ganglia	SIMA	10.5
Autonomic ganglia	SKNAS	9
Autonomic ganglia	SKNBE2	9.9
Autonomic ganglia	SKNDZ	10.9
Autonomic ganglia	SKNFI	10.5
Autonomic ganglia	SKNSH	10
Biliary tract	HUCCT1	10.8
Biliary tract	HUH28	9.6
Biliary tract	SNU1079	10.5
Biliary tract	SNU1196	10.9
Biliary tract	SNU245	10.6
Biliary tract	SNU308	10.6
Biliary tract	SNU478	10.4
Bone	143B	10
Bone	A673	9.5
Bone	CADOES1	10.8
Bone	CAL78	9.9
Bone	G292CLONEA141B1	10.6
Bone	HOS	9.7
Bone	HS706T	9.7
Bone	HS737T	9.5
Bone	HS819T	9.3
Bone	HS821T	9.7
Bone	HS822T	9.1
Bone	HS863T	9.8
Bone	HS870T	9.8
Bone	HS888T	10.2
Bone	MG63	10.8
Bone	MHHES1	9.6
Bone	OUMS27	9.5
Bone	RDES	10.7
Bone	SJSA1	10.4
Bone	SKES1	10.4
Bone	SKNMC	10.8
Bone	SW1353	9.8
Bone	T173	9.6
Bone	TC71	9.8
Bone	U2OS	10.5
Breast	AU565	9.4
Breast	BT20	9.9
Breast	BT474	10.8
Breast	BT483	11
Breast	BT549	9.7
Breast	CAL120	10.5
Breast	CAL148	10
Breast	CAL51	10.9
Breast	CAL851	10.6
Breast	CAMA1	10.5
Breast	DU4475	11.2
Breast	EFM192A	9.7
Breast	EFM19	12.1
Breast	EVSAT	10.5
Breast	HCC1143	10.5
Breast	HCC1187	9.9
Breast	HCC1395	9.8
Breast	HCC1419	9.9
Breast	HCC1428	9.8
Breast	HCC1500	11.4
Breast	HCC1569	10.2
Breast	HCC1599	11.9
Breast	HCC1806	10.2
Breast	HCC1937	10.5
Breast	HCC1954	10.3
Breast	HCC202	9.8
Breast	HCC2157	9.9
Breast	HCC2218	10.1
Breast	HCC38	11.2
Breast	HCC70	9.8
Breast	HDQP1	10.7
Breast	HMC18	10.8
Breast	HS274T	9.9
Breast	HS281T	9.8
Breast	HS343T	9.9
Breast	HS578T	9.2
Breast	HS606T	9.5
Breast	HS739T	9.5
Breast	HS742T	9.1
Breast	JIMT1	10.8
Breast	KPL1	9.4
Breast	MCF7	9.4
Breast	MDAMB134VI	10.8
Breast	MDAMB157	10.6
Breast	MDAMB175VII	10.5
Breast	MDAMB231	10.6
Breast	MDAMB361	10.2
Breast	MDAMB415	10.2
Breast	MDAMB436	9.5
Breast	MDAMB453	11
Breast	MDAMB468	9.8
Breast	SKBR3	9.4
Breast	T47D	11.1
Breast	UACC812	9.8
Breast	UACC893	10
Breast	YMB1	10.4
Breast	ZR751	10.7
Breast	ZR7530	9.6
Central nervous system	1321N1	10.3
Central nervous system	42MGBA	8.8
Central nervous system	8MGBA	10
Central nervous system	A172	11.2
Central nervous system	AM38	10.5
Central nervous system	BECKER	10.2
Central nervous system	CAS1	10.8
Central nervous system	CCFSTTG1	10.4
Central nervous system	D283MED	11
Central nervous system	D341MED	11.1
Central nervous system	DAOY	10.7
Central nervous system	DBTRG05MG	10.1
Central nervous system	DKMG	10.4
Central nervous system	GAMG	10.5
Central nervous system	GB1	11.1
Central nervous system	GI1	10.6
Central nervous system	GMS10	10.3
Central nervous system	GOS3	10.9
Central nervous system	H4	9.7
Central nervous system	HS683	10.4
Central nervous system	KALS1	9.8
Central nervous system	KG1C	9.6
Central nervous system	KNS42	10.8
Central nervous system	KNS60	9.6
Central nervous system	KNS81	10.2
Central nervous system	KS1	10.6
Central nervous system	LN18	10.6
Central nervous system	LN229	10.4
Central nervous system	M059K	9.8
Central nervous system	MOGGCCM	9.3
Central nervous system	MOGGUVW	10.1
Central nervous system	NMCG1	10.2
Central nervous system	ONS76	10.2
Central nervous system	SF126	10.1
Central nervous system	SF295	10.8
Central nervous system	SNB19	10.5
Central nervous system	SNU1105	10
Central nervous system	SNU201	10
Central nervous system	SNU466	9.1
Central nervous system	SNU489	9.1
Central nervous system	SNU626	10.5
Central nervous system	SNU738	9.6
Central nervous system	SW1088	9.9
Central nervous system	SW1783	10.5
Central nervous system	T98G	9.8
Central nervous system	TM31	9.8
Central nervous system	U118MG	10.3
Central nervous system	U138MG	9.4
Central nervous system	U251MG	10.3
Central nervous system	U87MG	9.6
Central nervous system	YH13	10.5
Central nervous system	YKG1	10.8
Endometrium	AN3CA	10.5
Endometrium	COLO684	11.2
Endometrium	EFE184	10.5
Endometrium	EN	10.9
Endometrium	ESS1	10.6
Endometrium	HEC108	9.8
Endometrium	HEC151	10.3
Endometrium	HEC1A	11.1
Endometrium	HEC1B	11.4
Endometrium	HEC251	10.7
Endometrium	HEC265	10.4
Endometrium	HEC50B	10.7
Endometrium	HEC59	11.1
Endometrium	HEC6	10.1
Endometrium	ISHIKAWAHERAKLIO02ER	10.8
Endometrium	JHUEM1	10.3
Endometrium	JHUEM2	10.9
Endometrium	JHUEM3	10.1
Endometrium	KLE	9.4
Endometrium	MFE280	9
Endometrium	MFE296	11
Endometrium	MFE319	10.2
Endometrium	RL952	10.2
Endometrium	SNGM	9.5
Endometrium	SNU1077	9.7
Endometrium	SNU685	9.7
Endometrium	TEN	9.7
Haematopoietic and lymphoid	697	11.2
Haematopoietic and lymphoid	A3KAW	11.2
Haematopoietic and lymphoid	A4FUK	11.1
Haematopoietic and lymphoid	ALLSIL	11.2
Haematopoietic and lymphoid	AML193	10.2
Haematopoietic and lymphoid	AMO1	11.7
Haematopoietic and lymphoid	BCP1	11.1
Haematopoietic and lymphoid	BDCM	11
Haematopoietic and lymphoid	BL41	11.5
Haematopoietic and lymphoid	BL70	11.6
Haematopoietic and lymphoid	BV173	11.3
Haematopoietic and lymphoid	CA46	11
Haematopoietic and lymphoid	CI1	11.4
Haematopoietic and lymphoid	CMK115	10.9
Haematopoietic and lymphoid	CMK86	11.1
Haematopoietic and lymphoid	CMK	10.9
Haematopoietic and lymphoid	CMLT1	11.1
Haematopoietic and lymphoid	COLO775	10.9
Haematopoietic and lymphoid	DAUDI	11.1
Haematopoietic and lymphoid	DB	10.7
Haematopoietic and lymphoid	DEL	10.4
Haematopoietic and lymphoid	DND41	10.7
Haematopoietic and lymphoid	DOHH2	11.6
Haematopoietic and lymphoid	EB1	11.1
Haematopoietic and lymphoid	EB2	11.1
Haematopoietic and lymphoid	EHEB	10.9
Haematopoietic and lymphoid	EJM	11.2
Haematopoietic and lymphoid	EM2	12.2
Haematopoietic and lymphoid	EOL1	11.4
Haematopoietic and lymphoid	F36P	10.1
Haematopoietic and lymphoid	GA10	11.4
Haematopoietic and lymphoid	GDM1	11.3
Haematopoietic and lymphoid	GRANTA519	10.3
Haematopoietic and lymphoid	HDLM2	10.2
Haematopoietic and lymphoid	HDMYZ	9.8
Haematopoietic and lymphoid	HEL9217	11.2
Haematopoietic and lymphoid	HEL	11.3
Haematopoietic and lymphoid	HH	11.4
Haematopoietic and lymphoid	HL60	11.6
Haematopoietic and lymphoid	HPBALL	11.2
Haematopoietic and lymphoid	HS604T	9.3
Haematopoietic and lymphoid	HS611T	11
Haematopoietic and lymphoid	HS616T	9.6
Haematopoietic and lymphoid	HS751T	10
Haematopoietic and lymphoid	HT	11.6
Haematopoietic and lymphoid	HTK	7
Haematopoietic and lymphoid	HUNS1	11.1
Haematopoietic and lymphoid	HUT102	10.6
Haematopoietic and lymphoid	HUT78	11.1
Haematopoietic and lymphoid	JEKO1	10.1
Haematopoietic and lymphoid	JK1	11.2
Haematopoietic and lymphoid	JM1	11.7
Haematopoietic and lymphoid	JURKAT	11
Haematopoietic and lymphoid	JURLMK1	11.5
Haematopoietic and lymphoid	JVM2	10.7
Haematopoietic and lymphoid	JVM3	11
Haematopoietic and lymphoid	K562	10.7
Haematopoietic and lymphoid	KARPAS299	10.7
Haematopoietic and lymphoid	KARPAS422	11.6
Haematopoietic and lymphoid	KARPAS620	11.4
Haematopoietic and lymphoid	KASUMI1	11.2
Haematopoietic and lymphoid	KASUMI2	11.2
Haematopoietic and lymphoid	KASUMI6	10.9
Haematopoietic and lymphoid	KCL22	11
Haematopoietic and lymphoid	KE37	11.4
Haematopoietic and lymphoid	KE97	11.3
Haematopoietic and lymphoid	KG1	11.2
Haematopoietic and lymphoid	KHM1B	11.1
Haematopoietic and lymphoid	KIJK	10.5
Haematopoietic and lymphoid	KMH2	11.2
Haematopoietic and lymphoid	KMM1	11.5
Haematopoietic and lymphoid	KMS11	11.7
Haematopoietic and lymphoid	KMS12BM	11.8
Haematopoietic and lymphoid	KMS18	11.3
Haematopoietic and lymphoid	KMS20	11.6
Haematopoietic and lymphoid	KMS21BM	10.6
Haematopoietic and lymphoid	KMS26	11
Haematopoietic and lymphoid	KMS27	10.5
Haematopoietic and lymphoid	KMS28BM	11.1
Haematopoietic and lymphoid	KMS34	11.2
Haematopoietic and lymphoid	KO52	10.7
Haematopoietic and lymphoid	KOPN8	10.8
Haematopoietic and lymphoid	KU812	9.7
Haematopoietic and lymphoid	KYO1	10.6
Haematopoietic and lymphoid	L1236	11
Haematopoietic and lymphoid	L363	11.3
Haematopoietic and lymphoid	L428	11.6
Haematopoietic and lymphoid	L540	11.8
Haematopoietic and lymphoid	LAMA84	11.7
Haematopoietic and lymphoid	LOUCY	11.4
Haematopoietic and lymphoid	LP1	10.2
Haematopoietic and lymphoid	M07E	11.1
Haematopoietic and lymphoid	MC116	11.1
Haematopoietic and lymphoid	ME1	10.1
Haematopoietic and lymphoid	MEC1	11.8
Haematopoietic and lymphoid	MEC2	11.1
Haematopoietic and lymphoid	MEG01	10.7
Haematopoietic and lymphoid	MHHCALL2	11.6
Haematopoietic and lymphoid	MHHCALL3	11.4
Haematopoietic and lymphoid	MHHCALL4	11.5
Haematopoietic and lymphoid	MINO	11.4
Haematopoietic and lymphoid	MJ	10.8
Haematopoietic and lymphoid	MM1S	11.4
Haematopoietic and lymphoid	MOLM13	11
Haematopoietic and lymphoid	MOLM16	10.9
Haematopoietic and lymphoid	MOLM6	11.2
Haematopoietic and lymphoid	MOLP2	11.1
Haematopoietic and lymphoid	MOLP8	10.9
Haematopoietic and lymphoid	MOLT13	11.6
Haematopoietic and lymphoid	MOLT16	11.5
Haematopoietic and lymphoid	MOLT4	11.2
Haematopoietic and lymphoid	MONOMAC1	11.3
Haematopoietic and lymphoid	MONOMAC6	11.5
Haematopoietic and lymphoid	MOTN1	11
Haematopoietic and lymphoid	MUTZ5	11.2
Haematopoietic and lymphoid	MV411	11.3
Haematopoietic and lymphoid	NALM19	11.1
Haematopoietic and lymphoid	NALM1	11.4
Haematopoietic and lymphoid	NALM6	11.6
Haematopoietic and lymphoid	NAMALWA	11.3
Haematopoietic and lymphoid	NB4	11.7
Haematopoietic and lymphoid	NCIH929	11.2
Haematopoietic and lymphoid	NCO2	11
Haematopoietic and lymphoid	NOMO1	11.1
Haematopoietic and lymphoid	NUDHL1	11
Haematopoietic and lymphoid	NUDUL1	11.6
Haematopoietic and lymphoid	OCIAML2	11.4
Haematopoietic and lymphoid	OCIAML3	11.2
Haematopoietic and lymphoid	OCIAML5	11.3
Haematopoietic and lymphoid	OCILY10	11.4
Haematopoietic and lymphoid	OCILY19	11
Haematopoietic and lymphoid	OCILY3	11.6
Haematopoietic and lymphoid	OCIM1	10.7
Haematopoietic and lymphoid	OPM2	11.1
Haematopoietic and lymphoid	P12ICHIKAWA	11.6
Haematopoietic and lymphoid	P31FUJ	10.8
Haematopoietic and lymphoid	P3HR1	11.6
Haematopoietic and lymphoid	PCM6	11.1
Haematopoietic and lymphoid	PEER	11.3
Haematopoietic and lymphoid	PF382	11.7
Haematopoietic and lymphoid	PFEIFFER	11.7
Haematopoietic and lymphoid	PL21	11.2
Haematopoietic and lymphoid	RAJI	11
Haematopoietic and lymphoid	RCHACV	11.1
Haematopoietic and lymphoid	REC1	11.1
Haematopoietic and lymphoid	REH	11.3
Haematopoietic and lymphoid	RI1	10.6
Haematopoietic and lymphoid	RL	11.3
Haematopoietic and lymphoid	RPMI8226	11
Haematopoietic and lymphoid	RPMI8402	11.8
Haematopoietic and lymphoid	RS411	11.1
Haematopoietic and lymphoid	SEM	11.3
Haematopoietic and lymphoid	SET2	10.9
Haematopoietic and lymphoid	SIGM5	11.7
Haematopoietic and lymphoid	SKM1	11.1
Haematopoietic and lymphoid	SKMM2	11.1
Haematopoietic and lymphoid	SR786	11.4
Haematopoietic and lymphoid	ST486	11.4
Haematopoietic and lymphoid	SUDHL10	10.7
Haematopoietic and lymphoid	SUDHL1	11.1
Haematopoietic and lymphoid	SUDHL4	10.8
Haematopoietic and lymphoid	SUDHL5	11.8
Haematopoietic and lymphoid	SUDHL6	11.5
Haematopoietic and lymphoid	SUDHL8	10.8
Haematopoietic and lymphoid	SUPB15	11.3
Haematopoietic and lymphoid	SUPHD1	10.6
Haematopoietic and lymphoid	SUPM2	10.5
Haematopoietic and lymphoid	SUPT11	11.1
Haematopoietic and lymphoid	SUPT1	11.1
Haematopoietic and lymphoid	TALL1	11.5
Haematopoietic and lymphoid	TF1	10.9
Haematopoietic and lymphoid	THP1	11
Haematopoietic and lymphoid	TO175T	9.8
Haematopoietic and lymphoid	TOLEDO	11.5
Haematopoietic and lymphoid	U266B1	11.4
Haematopoietic and lymphoid	U937	10.7
Haematopoietic and lymphoid	UT7	10.5
Haematopoietic and lymphoid	WSUDLCL2	11
Kidney	769P	9.7
Kidney	786O	9.5
Kidney	A498	9.8
Kidney	A704	9.9
Kidney	ACHN	10.4
Kidney	BFTC909	10.7
Kidney	CAKI1	9.8
Kidney	CAKI2	10
Kidney	CAL54	10.4
Kidney	KMRC1	10.5
Kidney	KMRC20	10.1
Kidney	KMRC2	10
Kidney	KMRC3	9.2
Kidney	OSRC2	9.7
Kidney	RCC10RGB	9.6
Kidney	SNU1272	9.7
Kidney	SNU349	8.7
Kidney	TUHR10TKB	10.1
Kidney	TUHR14TKB	9.9
Kidney	TUHR4TKB	10
Kidney	VMRCRCW	8.8
Kidney	VMRCRCZ	10.4
Large intestine	C2BBE1	10.3
Large intestine	CCK81	11.1
Large intestine	CL11	10.9
Large intestine	CL14	10.3
Large intestine	CL34	10.8
Large intestine	CL40	9.8
Large intestine	COLO205	10.7
Large intestine	COLO320	10.4
Large intestine	COLO678	12
Large intestine	CW2	9.9
Large intestine	DLD1	10.7
Large intestine	GP2D	11.1
Large intestine	HCC56	9.8
Large intestine	HCT116	10.6
Large intestine	HCT15	11.2
Large intestine	HS675T	9.5
Large intestine	HS698T	9.9
Large intestine	HT115	10.4
Large intestine	HT29	11.2
Large intestine	HT55	10.6
Large intestine	KM12	11.1
Large intestine	LOVO	10.7
Large intestine	LS1034	10.3
Large intestine	LS123	10.1
Large intestine	LS180	10.5
Large intestine	LS411N	11.2
Large intestine	LS513	10.1
Large intestine	MDST8	9.9
Large intestine	NCIH508	10.6
Large intestine	NCIH716	10
Large intestine	NCIH747	10.9
Large intestine	OUMS23	10.7
Large intestine	RCM1	10.4
Large intestine	RKO	11.4
Large intestine	SKCO1	10.8
Large intestine	SNU1040	10.6
Large intestine	SNU1197	10.8
Large intestine	SNU175	10.8
Large intestine	SNU283	10.7
Large intestine	SNU407	10.1
Large intestine	SNU503	10.7
Large intestine	SNU61	10.6
Large intestine	SNU81	10.7
Large intestine	SNUC1	10.3
Large intestine	SNUC2A	10.5
Large intestine	SNUC4	10.6
Large intestine	SNUC5	10.9
Large intestine	SW1116	10.4
Large intestine	SW1417	10.7
Large intestine	SW1463	10.4
Large intestine	SW403	10.2
Large intestine	SW480	10.7
Large intestine	SW48	11
Large intestine	SW620	10.6
Large intestine	SW837	11
Large intestine	SW948	10.5
Large intestine	T84	10
Liver	ALEXANDERCELLS	10.5
Liver	C3A	9.8
Liver	HEP3B217	10.9
Liver	HEPG2	9.8
Liver	HLE	11
Liver	HLF	10.6
Liver	HUH1	10.3
Liver	HUH6	10.1
Liver	HUH7	10.1
Liver	JHH1	10.1
Liver	JHH2	9
Liver	JHH4	10.8
Liver	JHH5	10.6
Liver	JHH6	10.3
Liver	JHH7	11
Liver	LI7	10.9
Liver	PLCPRF5	10.6
Liver	SKHEP1	10.7
Liver	SNU182	9.6
Liver	SNU387	9.4
Liver	SNU398	10.6
Liver	SNU423	10.4
Liver	SNU449	10.3
Liver	SNU475	10.2
Liver	SNU761	10
Liver	SNU878	10.6
Liver	SNU886	10.8
Lung	A549	10.6
Lung	ABC1	10.5
Lung	BEN	9.6
Lung	CAL12T	10.1
Lung	CALU1	10.5
Lung	CALU3	10.9
Lung	CALU6	9.7
Lung	CHAGOK1	10.8
Lung	COLO668	10.2
Lung	COLO699	9.7
Lung	CORL105	10.4
Lung	CORL23	10
Lung	CORL24	11.5
Lung	CORL279	11.2
Lung	CORL311	11.1
Lung	CORL47	10.6
Lung	CORL51	11
Lung	CORL88	10.5
Lung	CORL95	10.8
Lung	CPCN	11.7
Lung	DMS114	10.7
Lung	DMS153	10.4
Lung	DMS273	10.9
Lung	DMS454	11
Lung	DMS53	9.9
Lung	DMS79	11.1
Lung	DV90	10.7
Lung	EBC1	10.6
Lung	EPLC272H	9.8
Lung	HARA	10.8
Lung	HCC1171	10.7
Lung	HCC1195	9.7
Lung	HCC15	10.1
Lung	HCC2279	10.4
Lung	HCC2935	10.8
Lung	HCC33	11.4
Lung	HCC366	10.5
Lung	HCC4006	10
Lung	HCC44	10.5
Lung	HCC78	10.6
Lung	HCC827	9.8
Lung	HCC95	10.6
Lung	HLC1	10.7
Lung	HLFA	9.5
Lung	HS229T	10.4
Lung	HS618T	9.8
Lung	IALM	10.5
Lung	KNS62	10.2
Lung	LC1F	11.1
Lung	LC1SQSF	10.5
Lung	LCLC103H	10.3
Lung	LCLC97TM1	10.2
Lung	LK2	10.8
Lung	LOUNH91	9.6
Lung	LU65	10.8
Lung	LU99	11
Lung	LUDLU1	10.7
Lung	LXF289	10.7
Lung	MORCPR	10.8
Lung	NCIH1048	11.4
Lung	NCIH1092	11.1
Lung	NCIH1105	11.2
Lung	NCIH1155	11.1
Lung	NCIH1184	11.8
Lung	NCIH1299	9.9
Lung	NCIH1339	10.6
Lung	NCIH1341	10.6
Lung	NCIH1355	10.1
Lung	NCIH1373	10.9
Lung	NCIH1385	11.2
Lung	NCIH1395	10.2
Lung	NCIH1435	10.7
Lung	NCIH1436	11.4
Lung	NCIH1437	10
Lung	NCIH146	10.6
Lung	NCIH1563	10.7
Lung	NCIH1568	10.5
Lung	NCIH1573	10.4
Lung	NCIH1581	11.4
Lung	NCIH1618	11.7
Lung	NCIH1623	10.7
Lung	NCIH1648	10.7
Lung	NCIH1650	10.2
Lung	NCIH1651	10.1
Lung	NCIH1666	10
Lung	NCIH1693	9.8
Lung	NCIH1694	11.3
Lung	NCIH1703	11
Lung	NCIH1734	10.6
Lung	NCIH1755	10.4
Lung	NCIH1781	11.2
Lung	NCIH1792	10.7
Lung	NCIH1793	10.1
Lung	NCIH1836	11.3
Lung	NCIH1838	10.6
Lung	NCIH1869	11
Lung	NCIH1876	10.9
Lung	NCIH1915	9.6
Lung	NCIH1930	10.7
Lung	NCIH1944	10.9
Lung	NCIH1963	11.1
Lung	NCIH196	10.8
Lung	NCIH1975	10
Lung	NCIH2009	11.6
Lung	NCIH2023	10.6
Lung	NCIH2029	11
Lung	NCIH2030	10.2
Lung	NCIH2066	11
Lung	NCIH2081	10.7
Lung	NCIH2085	10.3
Lung	NCIH2087	9.6
Lung	NCIH209	10.9
Lung	NCIH2106	10.5
Lung	NCIH2110	10.3
Lung	NCIH211	11.1
Lung	NCIH2122	10.2
Lung	NCIH2126	10.7
Lung	NCIH2141	11.5
Lung	NCIH2170	10.3
Lung	NCIH2171	10.4
Lung	NCIH2172	10.3
Lung	NCIH2196	10.1
Lung	NCIH2227	10.5
Lung	NCIH2228	10.4
Lung	NCIH226	10.1
Lung	NCIH2286	11.2
Lung	NCIH2291	10.2
Lung	NCIH2342	11.1
Lung	NCIH2347	10.6
Lung	NCIH23	10.8
Lung	NCIH2405	10.8
Lung	NCIH2444	6.2
Lung	NCIH292	10.2
Lung	NCIH322	10.4
Lung	NCIH3255	9.9
Lung	NCIH358	10.8
Lung	NCIH441	10.4
Lung	NCIH446	10.7
Lung	NCIH460	10.5
Lung	NCIH510	10.7
Lung	NCIH520	11.4
Lung	NCIH522	10.4
Lung	NCIH524	10.9
Lung	NCIH526	10.9
Lung	NCIH596	9.6
Lung	NCIH647	9.4
Lung	NCIH650	10.3
Lung	NCIH661	10.4
Lung	NCIH69	11.2
Lung	NCIH727	11.3
Lung	NCIH810	10.7
Lung	NCIH82	10.7
Lung	NCIH838	11.3
Lung	NCIH841	11.8
Lung	NCIH854	9.4
Lung	NCIH889	11.1
Lung	PC14	9.7
Lung	RERFLCAD1	10.5
Lung	RERFLCAD2	10.5
Lung	RERFLCAI	8.8
Lung	RERFLCKJ	10.1
Lung	RERFLCMS	10
Lung	RERFLCSQ1	10.8
Lung	SBC5	10.3
Lung	SCLC21H	10.9
Lung	SHP77	10.5
Lung	SKLU1	10.6
Lung	SKMES1	9.2
Lung	SQ1	11.1
Lung	SW1271	10.4
Lung	SW1573	10.9
Lung	SW900	9.6
Lung	VMRCLCD	11.1
Lung	VMRCLCP	10.8
Oesophagus	COLO680N	10.5
Oesophagus	ECGI10	10.5
Oesophagus	KYSE140	10.3
Oesophagus	KYSE150	9.7
Oesophagus	KYSE180	10.7
Oesophagus	KYSE270	10.1
Oesophagus	KYSE30	9.6
Oesophagus	KYSE410	10.5
Oesophagus	KYSE450	10.2
Oesophagus	KYSE510	10.6
Oesophagus	KYSE520	9.9
Oesophagus	KYSE70	11.1
Oesophagus	OE19	9.8
Oesophagus	OE33	11.8
Oesophagus	TE10	10.6
Oesophagus	TE11	10
Oesophagus	TE14	10.3
Oesophagus	TE15	10.6
Oesophagus	TE1	10.5
Oesophagus	TE4	10.1
Oesophagus	TE5	10.9
Oesophagus	TE6	11
Oesophagus	TE8	10.4
Oesophagus	TE9	10.1
Oesophagus	TT	10.8
Ovary	59M	9.6
Ovary	A2780	10.9
Ovary	CAOV3	9.6
Ovary	CAOV4	10.3
Ovary	COLO704	11.2
Ovary	COV318	10.1
Ovary	COV362	9.2
Ovary	COV434	11
Ovary	COV504	9.2
Ovary	COV644	10.3
Ovary	EFO21	10.2
Ovary	EFO27	10.3
Ovary	ES2	10.4
Ovary	FUOV1	10.6
Ovary	HEYA8	9.5
Ovary	HS571T	9.4
Ovary	IGROV1	10.5
Ovary	JHOC5	10.8
Ovary	JHOM1	10.3
Ovary	JHOM2B	9.7
Ovary	JHOS2	10.3
Ovary	JHOS4	9.8
Ovary	KURAMOCHI	9
Ovary	MCAS	10.7
Ovary	NIHOVCAR3	9.9
Ovary	OAW28	10.9
Ovary	OAW42	10.5
Ovary	OC314	10.7
Ovary	OC316	10.6
Ovary	ONCODG1	10.1
Ovary	OV56	9.9
Ovary	OV7	10.1
Ovary	OV90	10.4
Ovary	OVCAR4	9.8
Ovary	OVCAR8	10.7
Ovary	OVISE	10.5
Ovary	OVK18	10.2
Ovary	OVKATE	9.5
Ovary	OVMANA	11
Ovary	OVSAHO	9.9
Ovary	OVTOKO	10.6
Ovary	RMGI	9.5
Ovary	RMUGS	9.9
Ovary	SKOV3	10.7
Ovary	SNU119	8.8
Ovary	SNU840	10.2
Ovary	SNU8	10.4
Ovary	TOV112D	11.6
Ovary	TOV21G	10.4
Ovary	TYKNU	10.3
Pancreas	ASPC1	9.5
Pancreas	BXPC3	9.4
Pancreas	CAPAN1	10.9
Pancreas	CAPAN2	9.7
Pancreas	CFPAC1	10.3
Pancreas	DANG	10
Pancreas	HPAC	10.8
Pancreas	HPAFII	9.6
Pancreas	HS766T	9.6
Pancreas	HUPT3	9.6
Pancreas	HUPT4	10.6
Pancreas	KCIMOH1	10.2
Pancreas	KLM1	9.8
Pancreas	KP2	10.8
Pancreas	KP3	9.8
Pancreas	KP4	11
Pancreas	L33	10.8
Pancreas	MIAPACA2	10.9
Pancreas	PANC0203	11.1
Pancreas	PANC0213	9.8
Pancreas	PANC0327	10.9
Pancreas	PANC0403	10.6
Pancreas	PANC0504	10.4
Pancreas	PANC0813	10.4
Pancreas	PANC1005	10.9
Pancreas	PANC1	11.2
Pancreas	PATU8902	10.9
Pancreas	PATU8988S	10.7
Pancreas	PATU8988T	10.5
Pancreas	PK1	10.5
Pancreas	PK45H	10.1
Pancreas	PK59	9.9
Pancreas	PL45	11
Pancreas	PSN1	10.6
Pancreas	QGP1	10.8
Pancreas	SNU213	10.6
Pancreas	SNU324	10.5
Pancreas	SNU410	10.5
Pancreas	SU8686	10
Pancreas	SUIT2	10.8
Pancreas	SW1990	11.7
Pancreas	T3M4	10.7
Pancreas	TCCPAN2	9.8
Pancreas	YAPC	10.8
Pleura	ACCMESO1	10.2
Pleura	DM3	9.5
Pleura	ISTMES1	10.5
Pleura	ISTMES2	10.9
Pleura	JL1	9.6
Pleura	MPP89	10.1
Pleura	MSTO211H	10.5
Pleura	NCIH2052	10
Pleura	NCIH2452	10
Pleura	NCIH28	10.5
Prostate	22RV1	10.2
Prostate	DU145	10.5
Prostate	LNCAPCLONEFGC	10.5
Prostate	MDAPCA2B	10
Prostate	NCIH660	11.2
Prostate	PC3	9.6
Prostate	VCAP	11.6
Salivary gland	A253	10.4
Salivary gland	YD15	10.5
Skin	A101D	10.1
Skin	A2058	10.1
Skin	A375	10.3
Skin	C32	10.5
Skin	CHL1	10.5
Skin	CJM	10.4
Skin	COLO679	9.9
Skin	COLO741	10.3
Skin	COLO783	9.7
Skin	COLO792	10
Skin	COLO800	10.3
Skin	COLO818	10.2
Skin	COLO829	9.6
Skin	COLO849	10.3
Skin	G361	10.5
Skin	GRM	10.2
Skin	HMCB	10.6
Skin	HS294T	10
Skin	HS600T	9.6
Skin	HS688AT	9.2
Skin	HS695T	9.9
Skin	HS839T	9.9
Skin	HS852T	9.3
Skin	HS895T	9.9
Skin	HS934T	10
Skin	HS936T	10.4
Skin	HS939T	10.2
Skin	HS940T	9.3
Skin	HS944T	10.4
Skin	HT144	10.4
Skin	IGR1	10.1
Skin	IGR37	10.4
Skin	IGR39	10.6
Skin	IPC298	9.9
Skin	K029AX	10.1
Skin	LOXIMVI	10.6
Skin	MALME3M	10.1
Skin	MDAMB435S	10.2
Skin	MELHO	10.4
Skin	MELJUSO	9.9
Skin	MEWO	10.6
Skin	RPMI7951	10.1
Skin	RVH421	10
Skin	SH4	9.7
Skin	SKMEL1	10.6
Skin	SKMEL24	9.8
Skin	SKMEL28	10.3
Skin	SKMEL2	10.2
Skin	SKMEL30	10.2
Skin	SKMEL31	9.8
Skin	SKMEL3	10
Skin	SKMEL5	10.2
Skin	UACC257	10.3
Skin	UACC62	9.8
Skin	WM115	9.8
Skin	WM1799	10.6
Skin	WM2664	10.1
Skin	WM793	9.8
Skin	WM88	9.5
Skin	WM983B	10.1
Small intestine	HUTU80	11.2
Soft tissue	A204	10.3
Soft tissue	G401	10.4
Soft tissue	G402	10.2
Soft tissue	GCT	10.4
Soft tissue	HS729	10.5
Soft tissue	HT1080	10.2
Soft tissue	KYM1	10.9
Soft tissue	MESSA	10.2
Soft tissue	RD	10.4
Soft tissue	RH30	10.5
Soft tissue	RH41	11
Soft tissue	RKN	10
Soft tissue	S117	10.1
Soft tissue	SJRH30	11
Soft tissue	SKLMS1	9.5
Soft tissue	SKUT1	10.9
Soft tissue	TE125T	9.9
Soft tissue	TE159T	9.7
Soft tissue	TE441T	11.2
Soft tissue	TE617T	10.7
Stomach	2313287	10.4
Stomach	AGS	10.7
Stomach	AZ521	11
Stomach	ECC10	11.3
Stomach	ECC12	11.2
Stomach	FU97	10.2
Stomach	GCIY	10.8
Stomach	GSS	11.3
Stomach	GSU	10.8
Stomach	HGC27	10.6
Stomach	HS746T	9.8
Stomach	HUG1N	10.9
Stomach	IM95	10.5
Stomach	KATOIII	11.1
Stomach	KE39	11.2
Stomach	LMSU	10
Stomach	MKN1	10
Stomach	MKN45	10.8
Stomach	MKN74	10
Stomach	MKN7	9.9
Stomach	NCCSTCK140	10.3
Stomach	NCIN87	10.6
Stomach	NUGC2	9.3
Stomach	NUGC3	9.8
Stomach	NUGC4	9.6
Stomach	OCUM1	10.4
Stomach	RERFGC1B	11.1
Stomach	SH10TC	10.5
Stomach	SNU16	10.7
Stomach	SNU1	11.3
Stomach	SNU216	10.4
Stomach	SNU520	10.2
Stomach	SNU5	10.8
Stomach	SNU601	10.6
Stomach	SNU620	11
Stomach	SNU668	9.7
Stomach	SNU719	10.5
Stomach	TGBC11TKB	11
Thyroid	8305C	9.9
Thyroid	8505C	10.7
Thyroid	BCPAP	10.4
Thyroid	BHT101	9.9
Thyroid	CAL62	10.9
Thyroid	CGTHW1	9.9
Thyroid	FTC133	9.9
Thyroid	FTC238	10.8
Thyroid	ML1	9.4
Thyroid	SW579	9.5
Thyroid	TT2609C02	11.1
Thyroid	TT	10.7
Upper aerodigestive tract	BHY	10.8
Upper aerodigestive tract	BICR16	9.6
Upper aerodigestive tract	BICR18	9.8
Upper aerodigestive tract	BICR22	10
Upper aerodigestive tract	BICR31	9.7
Upper aerodigestive tract	BICR56	10.1
Upper aerodigestive tract	BICR6	10
Upper aerodigestive tract	CAL27	10
Upper aerodigestive tract	CAL33	10.1
Upper aerodigestive tract	DETROIT562	10.2
Upper aerodigestive tract	FADU	10.8
Upper aerodigestive tract	HS840T	9.9
Upper aerodigestive tract	HSC2	9.5
Upper aerodigestive tract	HSC3	10.2
Upper aerodigestive tract	HSC4	10.2
Upper aerodigestive tract	PECAPJ15	10.7
Upper aerodigestive tract	PECAPJ34CLONEC12	10.1
Upper aerodigestive tract	PECAPJ41CLONED2	9.7
Upper aerodigestive tract	PECAPJ49	9.6
Upper aerodigestive tract	SCC15	9.9
Upper aerodigestive tract	SCC25	9.9
Upper aerodigestive tract	SCC4	8.3
Upper aerodigestive tract	SCC9	9.6
Upper aerodigestive tract	SNU1076	9.7
Upper aerodigestive tract	SNU1214	10
Upper aerodigestive tract	SNU46	10.4
Upper aerodigestive tract	SNU899	9.9
Upper aerodigestive tract	YD10B	10.1
Upper aerodigestive tract	YD38	9.6
Upper aerodigestive tract	YD8	9.7
Urinary tract	5637	10.1
Urinary tract	639V	11.5
Urinary tract	647V	10.4
Urinary tract	BC3C	10.2
Urinary tract	BFTC905	11.1
Urinary tract	CAL29	10.5
Urinary tract	HS172T	9.8
Urinary tract	HT1197	9.8
Urinary tract	HT1376	9.9
Urinary tract	J82	10.1
Urinary tract	JMSU1	10.5
Urinary tract	KMBC2	10.8
Urinary tract	KU1919	10.7
Urinary tract	RT11284	10.4
Urinary tract	RT112	10.1
Urinary tract	RT4	10.6
Urinary tract	SCABER	10.4
Urinary tract	SW1710	10.1
Urinary tract	SW780	10.8
Urinary tract	T24	10.4
Urinary tract	TCCSUP	9.4
Urinary tract	UMUC1	9.6
Urinary tract	UMUC3	10.4
Urinary tract	VMCUB1	10.7

> The Human Protein Atlas (HPA)

[ TOP ]

Tissue	Expression Level (TPM)
Adipose tissue	13.9
Adrenal gland	15.7
Appendix	26
Bone marrow	28.5
Breast	18.6
Cerebral cortex	15.1
Cervix, uterine	17.8
Colon	15
Duodenum	16.5
Endometrium	25.2
Epididymis	14.4
Esophagus	15.7
Fallopian tube	17.7
Gallbladder	19.1
Heart muscle	6.9
Kidney	17.5
Liver	9.3
Lung	18.9
Lymph node	39.3
Ovary	13.9
Pancreas	2.4
Parathyroid gland	35.7
Placenta	26.6
Prostate	21.5
Rectum	18.5
Salivary gland	4.5
Seminal vesicle	17
Skeletal muscle	2.3
Skin	15.5
Small intestine	17.3
Smooth muscle	21.5
Spleen	25.8
Stomach	14.2
Testis	50.5
Thyroid gland	30.5
Tonsil	28.5
Urinary bladder	18.8

> Text Mining based Expression

[ TOP ]

PMID	Expression	Cancer	Evidence
28228691	overexpression	Tongue Squamous Cell Carcinoma	Our immunohistochemical staining data revealed aberrant overexpression of SUZ12 in a large subset of TSCC as compared to normal tongue mucosa.
27311868	Overexpression	B cell neoplasm; natural killer cell neoplasm	B-cell neoplasms showed a significant over-expression of EZH2, EED and SUZ12 in the aggressive subtypes compared to the indolent subtypes and normal tissue (p= 0.000-0.046) while expression of EZH1 was decreased in mantle cell lymphoma compared to normal tissue (p= 0.011).
26017281	Overexpression	Chronic Myeloid Leukemia	Here, luciferase data confirmed significantly higher and specificer promoter activity of the ARE/SUZ12 composite component in CML blast crisis-derived cell lines (K562, KCL22, and K562/G01) compared to HepG2 cells, and Ad-AS-TK/GCV system could exhibit enhanced apoptotic effects and decreased cell viability for BP-CML cell lines.
25855382	Underexpression	HBV-associated hepatocellular neoplasm	Clinically, similar effects were documented in a set of HBV-related liver tumors consistent with the likelihood that downregulation of SUZ12 and ZNF198 leads to epigenetic reprogramming of infected hepatocytes.
25699394	Overexpression	Gastric Carcinoma	We found the expression of SUZ12 in gastric carcinoma tissues (23.58±9.89%) was obviously higher than that in para-cancer tissue (1.12%±0.12%) (p<0.01).
25672609	Overexpression	Gastric Carcinoma	In this study, we found that SUZ12 expression was significantly increased in 64 gastric tumor tissues compared with normal tissues.
25326896	Overexpression	Colorectal Carcinoma	We found that overall EZH2, EED and SUZ12 mRNA expression in the CRC tissues was significantly increased than in the non-cancerous tissue (p < 0.05).
25243792	Overexpression	Colorectal Carcinoma	In search for new biomarkers, we investigated the expression of Polycomb-group (PcG) proteins EZH2, BMI1 and SUZ12 and associated histone modification H3K27me3 in colorectal cancer. Nuclear expression of PcG proteins and histone modification H3K27me3 were immunohistochemically (IHC) stained on a tissue microarray (TMA), including 247 tumor tissues and 47 normal tissues, and scored using the semi-automated Ariol system. Tumor tissues showed higher expression of EZH2 (p=0.05) and H3K27me3 (p<0.001) as compared to their normal counterparts. Combined marker trend analyses indicated that an increase in the number of markers showing high expression was associated with better prognosis. High expression of all four markers in the combined marker analyses was correlated with the best patient survival and the longest recurrence-free survival, with overall survival (p=0.01, HR 0.42(0.21-0.84)), disease-free survival (p=0.007, HR 0.23(0.08-0.67) and local recurrence-free survival (p=0.02, HR 0.30(0.11-0.84)).
26176059	Overexpression	Gastric Carcinoma	We found the expression of SUZ12 in gastric carcinoma tissues (23.58 ± 9.89%) was obviously higher than that in para-cancer tissue (1.12% ± 0.12%) (p < 0.01).
24633887	Overexpression	non-Small Cell Lung Carcinoma	The results showed that SUZ12 was anomalously expressed in NSCLC tissues compared to adjacent noncancerous tissues (P<0.05) and was highly correlated to tumor size, lymph node metastasis, and clinical stages (P<0.05).
22964433	Overexpression	Ovarian Carcinoma	Here, we show that SUZ12 is expressed at significantly higher levels in human EOC (n = 117) compared with either normal human ovarian surface epithelium (n = 35, P < 0.001) or fallopian tube epithelium (n = 15, P < 0.001).
21480320	Underexpression	HBV-associated Hepatocellular Carcinoma	Elevated Plk1 and reduced protein levels of ZNF198 and SUZ12 were also observed in human liver cancer cell lines derived from HBV-related tumors and in the presence of HBV replication.
21115743	Overexpression	Ovarian Carcinoma	Here, we investigated the expression and function of EZH2 in epithelial ovarian cancer (EOC). When compared with primary human ovarian surface epithelial (pHOSE) cells, EZH2, SUZ12, and EED were expressed at higher levels in all 8 human EOC cell lines tested.
20558579	altered expression; Copy Number Gain	mantle cell Lymphoma; pulmonary carcinoma; Melanoma	Here we show that SUZ12 is anomalously expressed in human primary tumors, especially in mantle cell lymphoma (MCL), pulmonary carcinomas and melanoma, and is associated with gene locus amplification in some cases.

Summary
Symbol	SUZ12
Name	SUZ12 polycomb repressive complex 2 subunit
Aliases	JJAZ1; KIAA0160; CHET9; suppressor of zeste 12 homolog (Drosophila); chET 9 protein; chromatin precipitated ......
Location	17q11.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Somatic copy number alteration in primary tomur tissue

> The Cancer Genome Atlas (TCGA)

[ TOP ]

Correlation between expression and SCNA as well as percentage of patients in different status.

Cancer	Full Name	# Sample	R	P	% Loss	% Neutral	% Gain	Status
BLCA	Bladder urothelial carcinoma	404	0.597	2.25e-40	6.7	53.2	40.1	Gain
BRCA	Breast invasive carcinoma	1075	0.577	1.53e-96	32.4	47.6	20	Neutral
CESC	Cervical and endocervical cancers	292	0.444	1.43e-15	12.7	74	13.4	Neutral
COAD	Colon adenocarcinoma	449	0.276	2.76e-09	12.7	64.1	23.2	Neutral
ESCA	Esophageal carcinoma	183	0.35	1.16e-06	12	56.3	31.7	Neutral
GBM	Glioblastoma multiforme	147	0.288	0.000406	12.2	78.2	9.5	Neutral
HNSC	Head and Neck squamous cell carcinoma	514	0.222	3.64e-07	9.7	74.1	16.1	Neutral
KIRC	Kidney renal clear cell carcinoma	525	0.133	0.00224	6.1	88.2	5.7	Neutral
KIRP	Kidney renal papillary cell carcinoma	288	0.201	0.000598	0.7	35.1	64.2	Gain
LAML	Acute Myeloid Leukemia	166	0.493	1.49e-11	6.6	91.6	1.8	Neutral
LGG	Brain Lower Grade Glioma	513	0.216	7.62e-07	3.9	92.8	3.3	Neutral
LIHC	Liver hepatocellular carcinoma	364	0.44	1.11e-18	10.7	64.8	24.5	Neutral
LUAD	Lung adenocarcinoma	512	0.519	1.08e-36	11.3	49.8	38.9	Gain
LUSC	Lung squamous cell carcinoma	498	0.628	6.28e-56	25.1	44.4	30.5	Neutral
OV	Ovarian serous cystadenocarcinoma	300	0.637	1.62e-35	83.7	11.7	4.7	Loss
PAAD	Pancreatic adenocarcinoma	177	0.488	5.85e-12	10.7	75.7	13.6	Neutral
PCPG	Pheochromocytoma and Paraganglioma	162	0.758	1.63e-31	25.9	72.2	1.9	Neutral
PRAD	Prostate adenocarcinoma	491	0.18	6.16e-05	8.1	88.8	3.1	Neutral
READ	Rectum adenocarcinoma	164	0.216	0.00544	14	61.6	24.4	Neutral
SARC	Sarcoma	255	0.542	7.62e-21	30.2	55.3	14.5	Neutral
SKCM	Skin Cutaneous Melanoma	367	0.378	6.27e-14	21.5	62.7	15.8	Neutral
STAD	Stomach adenocarcinoma	413	0.489	3.24e-26	11.9	66.1	22	Neutral
TGCT	Testicular Germ Cell Tumors	150	0.252	0.00186	13.3	54	32.7	Neutral
THCA	Thyroid carcinoma	497	0.188	2.35e-05	0.2	95.8	4	Neutral
THYM	Thymoma	119	0.225	0.0138	5	86.6	8.4	Neutral
UCEC	Uterine Corpus Endometrial Carcinoma	537	0.349	7.99e-17	19.2	73.4	7.4	Neutral

Summary
Symbol	SUZ12
Name	SUZ12 polycomb repressive complex 2 subunit
Aliases	JJAZ1; KIAA0160; CHET9; suppressor of zeste 12 homolog (Drosophila); chET 9 protein; chromatin precipitated ......
Location	17q11.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Methylation level in the promoter region of CR

> Methylation level in the promoter region of CR

[ TOP ]

Correlation between expression and methylation as well as differential methylation analysis.

Cancer	Full Name	R	P	# N	# T	Delta beta (T vs N)	P value (T vs N)	Status
BLCA	Bladder urothelial carcinoma	-0.294	7.63e-10	17	408	-0.003	0.317	NS/NA
BRCA	Breast invasive carcinoma	-0.326	0	83	785	0	0.0244	NS/NA
CESC	Cervical and endocervical cancers	-0.231	4.17e-05	3	306	NA	NA	NS/NA
COAD	Colon adenocarcinoma	-0.113	0.0446	19	297	0.003	0.163	NS/NA
ESCA	Esophageal carcinoma	-0.174	0.0155	9	185	NA	NA	NS/NA
GBM	Glioblastoma multiforme	-0.241	0.053	1	64	NA	NA	NS/NA
HNSC	Head and Neck squamous cell carcinoma	-0.21	8.74e-07	20	522	-0.001	0.535	NS/NA
KIRC	Kidney renal clear cell carcinoma	-0.053	0.328	24	319	0.008	9.34e-13	NS/NA
KIRP	Kidney renal papillary cell carcinoma	-0.158	0.00649	23	275	0	0.302	NS/NA
LAML	Acute Myeloid Leukemia	-0.086	0.262	0	170	NA	NA	NS/NA
LGG	Brain Lower Grade Glioma	-0.121	0.00536	0	530	NA	NA	NS/NA
LIHC	Liver hepatocellular carcinoma	-0.191	9.72e-05	41	373	0.001	0.537	NS/NA
LUAD	Lung adenocarcinoma	-0.084	0.0658	21	456	-0.003	0.379	NS/NA
LUSC	Lung squamous cell carcinoma	-0.305	1.81e-09	8	370	NA	NA	NS/NA
OV	Ovarian serous cystadenocarcinoma	-0.9	0.00203	0	9	NA	NA	NS/NA
PAAD	Pancreatic adenocarcinoma	-0.173	0.0194	4	179	NA	NA	NS/NA
PCPG	Pheochromocytoma and Paraganglioma	-0.504	0	3	184	NA	NA	NS/NA
PRAD	Prostate adenocarcinoma	-0.255	2.62e-09	35	498	0.003	0.00331	NS/NA
READ	Rectum adenocarcinoma	-0.165	0.0995	2	99	NA	NA	NS/NA
SARC	Sarcoma	-0.345	1.2e-08	0	263	NA	NA	NS/NA
SKCM	Skin Cutaneous Melanoma	-0.249	4.93e-08	1	471	NA	NA	NS/NA
STAD	Stomach adenocarcinoma	-0.229	8.42e-06	0	372	NA	NA	NS/NA
TGCT	Testicular Germ Cell Tumors	-0.273	0.000588	0	156	NA	NA	NS/NA
THCA	Thyroid carcinoma	-0.112	0.0081	50	509	-0.002	0.152	NS/NA
THYM	Thymoma	-0.107	0.242	2	120	NA	NA	NS/NA
UCEC	Uterine Corpus Endometrial Carcinoma	-0.132	0.00447	34	431	0	0.712	NS/NA

Summary
Symbol	SUZ12
Name	SUZ12 polycomb repressive complex 2 subunit
Aliases	JJAZ1; KIAA0160; CHET9; suppressor of zeste 12 homolog (Drosophila); chET 9 protein; chromatin precipitated ......
Location	17q11.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Primary tumor tissue from TCGA > Normal tumor tissue from HPA

>The Cancer Genome Atlas (TCGA) [ TOP ]
There is no record.

> The Human Protein Atlas (HPA)

[ TOP ]

Tissue	Level	Level Name
Adrenal gland	0	Not detected
Appendix	2	Medium
Bone marrow	2	Medium
Breast	0	Not detected
Bronchus	0	Not detected
Caudate	0	Not detected
Cerebellum	0	Not detected
Cerebral cortex	0	Not detected
Cervix, uterine	0	Not detected
Colon	1	Low
Duodenum	1	Low
Endometrium	0	Not detected
Epididymis	0	Not detected
Esophagus	1	Low
Fallopian tube	1	Low
Gallbladder	2	Medium
Heart muscle	0	Not detected
Hippocampus	0	Not detected
Kidney	2	Medium
Liver	0	Not detected
Lung	0	Not detected
Lymph node	1	Low
Nasopharynx	0	Not detected
Oral mucosa	1	Low
Ovary	0	Not detected
Pancreas	0	Not detected
Placenta	1	Low
Prostate	0	Not detected
Rectum	1	Low
Salivary gland	0	Not detected
Seminal vesicle	0	Not detected
Skeletal muscle	0	Not detected
Skin	1	Low
Small intestine	1	Low
Smooth muscle	0	Not detected
Soft tissue	0	Not detected
Spleen	0	Not detected
Stomach	1	Low
Testis	0	Not detected
Thyroid gland	0	Not detected
Tonsil	2	Medium
Urinary bladder	0	Not detected
Vagina	1	Low

Summary
Symbol	SUZ12
Name	SUZ12 polycomb repressive complex 2 subunit
Aliases	JJAZ1; KIAA0160; CHET9; suppressor of zeste 12 homolog (Drosophila); chET 9 protein; chromatin precipitated ......
Location	17q11.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Association between expresson and subtype > Overall survival analysis based on expression > Association between expresson and stage > Association between expresson and grade

> Subtype

[ TOP ]

Association between expresson and subtype.

Cancer	Full Name	# Patients	P Value (Kruskal-Wallis)	Association	Source
BLCA	Bladder urothelial carcinoma	128	0.77	NS	24476821
BRCA	Breast invasive carcinoma	521	2.1e-08	Significant	23000897
COAD	Colon adenocarcinoma	149	0.262	NS	22810696
GBM	Glioblastoma multiforme	157	0.00101	Significant	26824661
HNSC	Head and Neck squamous cell carcinoma	279	2.2e-10	Significant	25631445
KIRP	Kidney renal papillary cell carcinoma	161	0.824	NS	26536169
LGG	Brain Lower Grade Glioma	513	0.694	NS	26824661
LUAD	Lung adenocarcinoma	230	8.58e-07	Significant	25079552
LUSC	Lung squamous cell carcinoma	178	8.78e-11	Significant	22960745
OV	Ovarian serous cystadenocarcinoma	287	1.52e-07	Significant	21720365
PRAD	Prostate adenocarcinoma	333	2.6e-10	Significant	26544944
READ	Rectum adenocarcinoma	67	0.928	NS	22810696
SKCM	Skin Cutaneous Melanoma	315	0.57	NS	26091043
STAD	Stomach adenocarcinoma	277	2.42e-13	Significant	25079317
THCA	Thyroid carcinoma	391	0.0284	Significant	25417114
UCEC	Uterine Corpus Endometrial Carcinoma	232	0.742	NS	23636398

> Overall survival

[ TOP ]

Overall survival analysis based on expression.

Cancer	Full Name	# Patients	Hazard Ratio	P Value (Log Rank Test)	Association
BLCA	Bladder urothelial carcinoma	405	1.196	0.395	NS
BRCA	Breast invasive carcinoma	1079	1.039	0.866	NS
CESC	Cervical and endocervical cancers	291	1.19	0.613	NS
COAD	Colon adenocarcinoma	439	0.672	0.184	NS
ESCA	Esophageal carcinoma	184	1.263	0.474	NS
GBM	Glioblastoma multiforme	158	0.94	0.828	NS
HNSC	Head and Neck squamous cell carcinoma	518	0.826	0.349	NS
KIRC	Kidney renal clear cell carcinoma	531	0.53	0.0022	Longer
KIRP	Kidney renal papillary cell carcinoma	287	1.183	0.708	NS
LAML	Acute Myeloid Leukemia	149	0.903	0.722	NS
LGG	Brain Lower Grade Glioma	511	1.885	0.0164	Shorter
LIHC	Liver hepatocellular carcinoma	365	1.596	0.0708	NS
LUAD	Lung adenocarcinoma	502	1.337	0.161	NS
LUSC	Lung squamous cell carcinoma	494	0.753	0.152	NS
OV	Ovarian serous cystadenocarcinoma	303	1.148	0.499	NS
PAAD	Pancreatic adenocarcinoma	177	1.248	0.442	NS
PCPG	Pheochromocytoma and Paraganglioma	179	0.652	0.637	NS
PRAD	Prostate adenocarcinoma	497	3.88	0.21	NS
READ	Rectum adenocarcinoma	159	0.42	0.175	NS
SARC	Sarcoma	259	1.506	0.179	NS
SKCM	Skin Cutaneous Melanoma	459	0.507	0.000538	Longer
STAD	Stomach adenocarcinoma	388	0.996	0.987	NS
TGCT	Testicular Germ Cell Tumors	134	1.061	0.967	NS
THCA	Thyroid carcinoma	500	1.177	0.808	NS
THYM	Thymoma	119	0	0.0483	Longer
UCEC	Uterine Corpus Endometrial Carcinoma	543	1.277	0.439	NS

> Stage

[ TOP ]

Association between expresson and stage.

Cancer	Full Name	# Patients	R Value (Spearman)	P Value (Spearman)	Association
BLCA	Bladder urothelial carcinoma	406	0.036	0.474	NS
BRCA	Breast invasive carcinoma	1071	-0.014	0.644	NS
CESC	Cervical and endocervical cancers	167	0.01	0.895	NS
COAD	Colon adenocarcinoma	445	-0.094	0.0484	Lower
ESCA	Esophageal carcinoma	162	0.021	0.787	NS
HNSC	Head and Neck squamous cell carcinoma	448	0.059	0.211	NS
KIRC	Kidney renal clear cell carcinoma	531	-0.15	0.000527	Lower
KIRP	Kidney renal papillary cell carcinoma	260	0.03	0.636	NS
LIHC	Liver hepatocellular carcinoma	347	0.105	0.0508	NS
LUAD	Lung adenocarcinoma	507	0.087	0.0515	NS
LUSC	Lung squamous cell carcinoma	497	0.06	0.183	NS
OV	Ovarian serous cystadenocarcinoma	302	-0.119	0.0382	Lower
PAAD	Pancreatic adenocarcinoma	176	0.004	0.953	NS
READ	Rectum adenocarcinoma	156	-0.028	0.729	NS
SKCM	Skin Cutaneous Melanoma	410	-0.035	0.482	NS
STAD	Stomach adenocarcinoma	392	-0.017	0.731	NS
TGCT	Testicular Germ Cell Tumors	81	-0.08	0.478	NS
THCA	Thyroid carcinoma	499	-0.002	0.968	NS
UCEC	Uterine Corpus Endometrial Carcinoma	501	0.086	0.054	NS

> Grade

[ TOP ]

Association between expresson and grade.

Cancer	Full Name	# Patients	R Value (Spearman)	P Value (Spearman)	Association
CESC	Cervical and endocervical cancers	272	-0.028	0.647	NS
HNSC	Head and Neck squamous cell carcinoma	498	0.124	0.00576	Higher
KIRC	Kidney renal clear cell carcinoma	525	-0.096	0.0273	Lower
LGG	Brain Lower Grade Glioma	514	0.167	0.000142	Higher
LIHC	Liver hepatocellular carcinoma	366	0.13	0.0125	Higher
OV	Ovarian serous cystadenocarcinoma	296	0.069	0.238	NS
PAAD	Pancreatic adenocarcinoma	176	-0.023	0.762	NS
STAD	Stomach adenocarcinoma	406	-0.168	0.000693	Lower
UCEC	Uterine Corpus Endometrial Carcinoma	534	0.204	2.11e-06	Higher

Summary
Symbol	SUZ12
Name	SUZ12 polycomb repressive complex 2 subunit
Aliases	JJAZ1; KIAA0160; CHET9; suppressor of zeste 12 homolog (Drosophila); chET 9 protein; chromatin precipitated ......
Location	17q11.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Targets inferred by reverse engineering method > Targets identified by ChIP-seq data

> Targets inferred by reverse engineering method [ TOP ]

> Targets identified by ChIP-seq data [ TOP ]

Summary
Symbol	SUZ12
Name	SUZ12 polycomb repressive complex 2 subunit
Aliases	JJAZ1; KIAA0160; CHET9; suppressor of zeste 12 homolog (Drosophila); chET 9 protein; chromatin precipitated ......
Location	17q11.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Drugs from DrugBank database

> Drugs from DrugBank database [ TOP ]
There is no record for SUZ12.

Summary
Symbol	SUZ12
Name	SUZ12 polycomb repressive complex 2 subunit
Aliases	JJAZ1; KIAA0160; CHET9; suppressor of zeste 12 homolog (Drosophila); chET 9 protein; chromatin precipitated ......
Location	17q11.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Protein-Protein Interaction Network > miRNA Regulatory Relationship > Interactions from Text Mining

> Protein-Protein Interaction Network [ TOP ]

> miRNA Regulatory Relationship [ TOP ]

> Interactions from Text Mining

[ TOP ]

PMID	Cancer	Hierarchy	Gene	Relation to CR	Evidence
27738815	Stromal Neoplasm	partner	JAZF1	Fusion	Low grade stromal neoplasms frequently show gene fusions, such as JAZF1/SUZ12.
27142911	Endometrial Stromal Sarcoma	partner	JAZF1	Fusion	The positive rate of JAZF1-SUZ12 fusion gene was 30.8% (12/39) in low-grade ESS.
26879382	Endometrial Carcinoma; stromal sarcoma	partner	JAZF1	Fusion	To date the JAZF1/SUZ12 gene fusion is by far the most frequent and seems to be the cytogenetic hallmark of ESN and LG-ESS.
26429873	Endometrioid Stromal Sarcoma	partner	JAZF1	Fusion	In this study, we performed whole-exome sequencing, transcriptome sequencing and copy number profiling for five ESSs (three low-grade ESS (LG-ESS) and two undifferentiated uterine sarcomas (UUSs)). All three LG-ESSs exhibited either one of JAZF1-SUZ12, JAZF1-PHF1 and MEAF6-PHF1 fusions, whereas the two UUSs did not.
25699394	Gastric Carcinoma	downstream	VEGF; MMP-2; MMP-9	Positive regulation	Inhibition of SUZ12 caused an obviously descent of VEGF, MMP-2 and MMP-9 (0.22±0.06, 0.12±0.03, 0.08±0.02) compared to non transfected group (0.87±0.08, 0.92±0.16, 1.05±0.18) respectively (p<0.01).
25672609	Gastric Carcinoma	downstream	EMT; KLF2	regulation	Upregulation of SUZ12 was found to play a key role in gastric cancer cell proliferation and metastasis through the regulation of EMT and KLF2 expression.
25355621	Endometrial Stromal Sarcoma	partner	JAZF1	Fusion	Low-grade ESSs frequently contain chromosomal rearrangements that result in JAZF1-SUZ12 fusion or equivalent genetic fusions.
25299308	Endometrial Stromal Nodule; Endometrial Stromal Sarcoma	partner	JAZF1	Fusion	Specifically, the JAZF1-SUZ12 (formerly JAZF1-JJAZ1) fusion identifies a large proportion of ESN and LG-ESSs, whereas the YWHAE-FAM22 translocation identifies HG-ESSs.
26176059	Gastric Carcinoma	downstream	VEGF; MMP2; MMP-9	Positive regulation	Inhibition of SUZ12 caused an obviously descent of VEGF, MMP-2 and MMP-9 (0.22 ± 0.06, 0.12 ± 0.03, 0.08 ± 0.02) compared to non transfected group (0.87 ± 0.08, 0.92 ± 0.16, 1.05 ± 0.18) respectively (p < 0.01).
24750188	Endometrial stromal tumor	partner	JAZF-1	Fusion	Both lesions demonstrated identical cytology and shared JAZF1-SUZ12 gene fusion.
24633887	non-Small Cell Lung Carcinoma	downstream	E2F1; ROCK1; ROBO1	Negative regulation	Altogether, we provide evidences suggesting that SUZ12 is an oncogene in NSCLC and can regulate NSCLC cells proliferation and metastasis partly via reducing E2F1, ROCK1, and ROBO1.
23159154	Endometrioid Stromal Sarcoma	partner	JAZF	Fusion	We studied a series of 6 YWHAE-FAM22 endometrial stromal sarcomas, 7 JAZF-SUZ12 endometrial stromal sarcomas, 3 JAZF1-PHF1/EPC1-PHF1 endometrial stromal sarcomas, 6 undifferentiated endometrial sarcomas, 4 uterine leiomyosarcomas, and 4 uterine adenosarcomas.
22964433	Ovarian Carcinoma	partner	EZH2; Ki67	Positive correlation	There is a positive correlation between expression of SUZ12 and EZH2 in human EOC (P < 0.001). In addition, expression of SUZ12 positively correlates with Ki67, a marker of cell proliferation (P < 0.001), and predicts shorter overall survival (P = 0.0078).
22964433	Ovarian Carcinoma	downstream	HPK	Negative regulation	Mechanistically, we identified Harakiri (HRK), a proapoptotic gene, as a novel SUZ12 target gene, and showed that HRK upregulation mediates apoptosis induced by SUZ12 knockdown in human EOC cells.
21480320	Endometrioid Stromal Sarcoma	partner	JAZF1	Fusion	In one of the 6 extrauterine endometrial stromal sarcoma cases, JAZF1-JJAZ1 fusion transcripts were detected by reverse transcriptase-polymerase chain reaction.
18580489	Endometrial Stromal Sarcoma; undifferentiated Endometrial Carcinomaetrial sarcoma	partner	JAZF1	Fusion	JAZF1-JJAZ1 fusion transcript was detected in 6 (50%) out of 12 ESS-LG and in 1 (33%) of 3 UES-U, whereas it was not detected in any of the cases of UES-P.
18264096	Endometrial Carcinoma	partner	JAZF1	Fusion	Loci on chromosome 10 include MSMB, which encodes beta-microseminoprotein, a primary constituent of semen and a proposed prostate cancer biomarker, and CTBP2, a gene with antiapoptotic activity; the locus on chromosome 7 is at JAZF1, a transcriptional repressor that is fused by chromosome translocation to SUZ12 in endometrial cancer.
17365822	Endometrial Stromal Nodule; Endometrial Stromal Sarcoma	partner	JAZF1	Fusion	ESS and ESN share the fusion gene JAZF1/JJAZ1 caused by a t(7;17)(p15;q21) translocation, whereas UES lacks a distinctive molecular alteration so far.
17197920	Endometrioid Stromal Sarcoma; Endometrial Stromal Nodule	partner	JAZF1	Fusion	Overall, evidence for the JAZF1-JJAZ1 fusion was found in 60% of endometrial stromal neoplasms analyzed (8/16 ESS and 4/4 stromal nodules).
16049311	Endometrioid Stromal Sarcoma	partner	JAZF1	Fusion	Hitherto only 31 cases, described by three different research groups, have shown JAZF1/JJAZ1 fusion in approximately 50% of all analyzed low-grade ESSs whereas it is less frequent in UESs.
15043312	Endometrial stromal tumor	partner	JAZF1	Fusion	JAZF1-JJAZ1 gene fusion transcripts were detected in five (33%) of 15 ESTs, including three of eight primary uterine, one of four metastatic, one of one extrauterine, and none of two recurrent cases. Most ESTs of classic histology showed evidence of JAZF1-JJAZ1 fusion (4 of 5 cases), whereas only one mixed smooth muscle ESN of 10 variant cases was positive.
12850374	Endometrioid Stromal Sarcoma	partner	JAZF1	Fusion	We report three additional cases of ESS with abnormal karyotypes, whose interpretation was based on the combined analysis by conventional cytogenetics and cross-species color banding FISH (RxFISH). The combination of G-banding and RxFISH in every case gave additional information beyond that obtained by either technique alone, determining the identity of even complex inter- as well as intrachromosomal rearrangements. In one of the three tumors, a t(7;17) was seen; molecular genetic studies identified the JAZF1/JJAZ1 fusion gene in this case.
11371647	Endometrial Carcinomaetrial stromal tumor	partner	JAZF1	Fusion	Analyses of tumor RNA indicate that a JAZF1/JJAZ1 fusion is present in all types of endometrial stromal tumors; however, the fusion appears to be rarer among endometrial stromal sarcomas that would be considered high-grade according to certain classification schemes.