CR2Cancer

Summary
Symbol	TP53BP1
Name	tumor protein p53 binding protein 1
Aliases	53BP1; p202; TDRD30; tumor protein p53-binding protein, 1; p53BP1; p53-binding protein 1; tumor protein 53-b ......
Location	15q15.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Domain, Function and Classification > Gene Ontology > KEGG and Reactome Pathway

> Domain, Function and Classification

[ TOP ]

Domain

PF09038 Tumour suppressor p53-binding protein-1 Tudor

Function

Double-strand break (DSB) repair protein involved in response to DNA damage, telomere dynamics and class-switch recombination (CSR) during antibody genesis (PubMed:12364621, PubMed:22553214, PubMed:23333306, PubMed:17190600, PubMed:21144835, PubMed:28241136). Plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs and specifically counteracting the function of the homologous recombination (HR) repair protein BRCA1 (PubMed:22553214, PubMed:23727112, PubMed:23333306). In response to DSBs, phosphorylation by ATM promotes interaction with RIF1 and dissociation from NUDT16L1/TIRR, leading to recruitment to DSBs sites (PubMed:28241136). Recruited to DSBs sites by recognizing and binding histone H2A monoubiquitinated at 'Lys-15' (H2AK15Ub) and histone H4 dimethylated at 'Lys-20' (H4K20me2), two histone marks that are present at DSBs sites (PubMed:23760478, PubMed:28241136, PubMed:17190600). Required for immunoglobulin class-switch recombination (CSR) during antibody genesis, a process that involves the generation of DNA DSBs (PubMed:23345425). Participates to the repair and the orientation of the broken DNA ends during CSR (By similarity). In contrast, it is not required for classic NHEJ and V(D)J recombination (By similarity). Promotes NHEJ of dysfunctional telomeres via interaction with PAXIP1 (PubMed:23727112).

Classification

Class	Modification	Substrate	Product	PubMed
Histone modification read	#	H4K79me2, H4K20me2	#	15525939

> Gene Ontology [ TOP ]
Biological Process	GO:0000075 cell cycle checkpoint GO:0000077 DNA damage checkpoint GO:0000726 non-recombinational repair GO:0006302 double-strand break repair GO:0006303 double-strand break repair via nonhomologous end joining GO:0009314 response to radiation GO:0010165 response to X-ray GO:0010212 response to ionizing radiation GO:0016925 protein sumoylation GO:0018205 peptidyl-lysine modification GO:0031570 DNA integrity checkpoint GO:0051090 regulation of sequence-specific DNA binding transcription factor activity GO:0051091 positive regulation of sequence-specific DNA binding transcription factor activity GO:0071214 cellular response to abiotic stimulus GO:0071478 cellular response to radiation GO:0071479 cellular response to ionizing radiation GO:0071481 cellular response to X-ray
Molecular Function	GO:0001076 transcription factor activity, RNA polymerase II transcription factor binding GO:0001085 RNA polymerase II transcription factor binding GO:0001102 RNA polymerase II activating transcription factor binding GO:0001104 RNA polymerase II transcription cofactor activity GO:0002039 p53 binding GO:0008134 transcription factor binding GO:0033613 activating transcription factor binding GO:0035064 methylated histone binding GO:0042393 histone binding
Cellular Component	GO:0000775 chromosome, centromeric region GO:0000776 kinetochore GO:0000777 condensed chromosome kinetochore GO:0000779 condensed chromosome, centromeric region GO:0000781 chromosome, telomeric region GO:0000793 condensed chromosome GO:0098687 chromosomal region

> KEGG and Reactome Pathway [ TOP ]
KEGG	hsa04621 NOD-like receptor signaling pathway
Reactome	R-HSA-1640170: Cell Cycle R-HSA-69620: Cell Cycle Checkpoints R-HSA-5693606: DNA Double Strand Break Response R-HSA-5693532: DNA Double-Strand Break Repair R-HSA-73894: DNA Repair R-HSA-69481: G2/M Checkpoints R-HSA-69473: G2/M DNA damage checkpoint R-HSA-5693567: HDR through Homologous Recombination (HR) or Single Strand Annealing (SSA) R-HSA-5693538: Homology Directed Repair R-HSA-392499: Metabolism of proteins R-HSA-5693571: Nonhomologous End-Joining (NHEJ) R-HSA-597592: Post-translational protein modification R-HSA-5693607: Processing of DNA double-strand break ends R-HSA-5693565: Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks R-HSA-3108232: SUMO E3 ligases SUMOylate target proteins R-HSA-2990846: SUMOylation R-HSA-3232118: SUMOylation of transcription factors

> KEGG and Reactome Pathway

[ TOP ]

KEGG

hsa04621 NOD-like receptor signaling pathway

Reactome

R-HSA-1640170: Cell Cycle
R-HSA-69620: Cell Cycle Checkpoints
R-HSA-5693606: DNA Double Strand Break Response
R-HSA-5693532: DNA Double-Strand Break Repair
R-HSA-73894: DNA Repair
R-HSA-69481: G2/M Checkpoints
R-HSA-69473: G2/M DNA damage checkpoint
R-HSA-5693567: HDR through Homologous Recombination (HR) or Single Strand Annealing (SSA)
R-HSA-5693538: Homology Directed Repair
R-HSA-392499: Metabolism of proteins
R-HSA-5693571: Nonhomologous End-Joining (NHEJ)
R-HSA-597592: Post-translational protein modification
R-HSA-5693607: Processing of DNA double-strand break ends
R-HSA-5693565: Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
R-HSA-3108232: SUMO E3 ligases SUMOylate target proteins
R-HSA-2990846: SUMOylation
R-HSA-3232118: SUMOylation of transcription factors

Summary
Symbol	TP53BP1
Name	tumor protein p53 binding protein 1
Aliases	53BP1; p202; TDRD30; tumor protein p53-binding protein, 1; p53BP1; p53-binding protein 1; tumor protein 53-b ......
Location	15q15.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Mutation landscape in primary tumor tissue from TCGA > Mutation landscape in cancer cell line from CCLE > All mutations from COSMIC database V81 > Variations from text mining

> The Cancer Genome Atlas (TCGA) [ TOP ]

> Cancer Cell Line Encyclopedia (CCLE) [ TOP ]

> Catalogue of Somatic Mutations in Cancer (COSMIC)

[ TOP ]

COSMIC ID	CDS change	AA change	Mutation Type	Anatomical Site
COSM3754330	c.3406A>C	p.K1136Q	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM225033	c.4976C>T	p.A1659V	Substitution - Missense	Skin
COSM3754332	c.1234G>A	p.G412S	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM4995573	c.3253C>T	p.Q1085*	Substitution - Nonsense	Upper_aerodigestive_tract
COSM3999533	c.177+7G>A	p.?	Unknown	Haematopoietic_and_lymphoid_tissue
COSM5478884	c.3800G>T	p.R1267I	Substitution - Missense	Large_intestine
COSM4054834	c.4063C>T	p.R1355*	Substitution - Nonsense	Stomach
COSM1708079	c.5287G>A	p.E1763K	Substitution - Missense	Skin
COSM1373023	c.2397G>T	p.E799D	Substitution - Missense	Large_intestine
COSM3386882	c.4003G>A	p.G1335R	Substitution - Missense	Pancreas
COSM3816137	c.2319A>T	p.E773D	Substitution - Missense	Breast
COSM2188307	c.3394C>T	p.R1132W	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM5725541	c.4650T>G	p.D1550E	Substitution - Missense	Skin
COSM4647821	c.1471A>T	p.K491*	Substitution - Nonsense	Large_intestine
COSM356791	c.5537A>G	p.Y1846C	Substitution - Missense	Lung
COSM700504	c.4569C>A	p.Y1523*	Substitution - Nonsense	Lung
COSM4657772	c.1102G>A	p.D368N	Substitution - Missense	Parathyroid
COSM2188341	c.919T>C	p.F307L	Substitution - Missense	Large_intestine
COSM673833	c.225C>A	p.D75E	Substitution - Missense	Endometrium
COSM4735459	c.1176G>T	p.M392I	Substitution - Missense	Large_intestine
COSM1478137	c.5444A>G	p.Y1815C	Substitution - Missense	Breast
COSM385657	c.1435G>A	p.D479N	Substitution - Missense	Lung
COSM5722305	c.1809T>C	p.G603G	Substitution - coding silent	Skin
COSM5895315	c.2702-4delT	p.?	Unknown	Skin
COSM4054835	c.3928T>C	p.S1310P	Substitution - Missense	Stomach
COSM3672051	c.2038A>T	p.K680*	Substitution - Nonsense	Prostate
COSM4974834	c.5308C>T	p.P1770S	Substitution - Missense	Oesophagus
COSM233632	c.2062C>T	p.P688S	Substitution - Missense	Skin
COSM3987966	c.1651A>T	p.M551L	Substitution - Missense	Kidney
COSM73047	c.3470T>G	p.M1157R	Substitution - Missense	Ovary
COSM3501438	c.117C>T	p.H39H	Substitution - coding silent	Skin
COSM3887015	c.1681C>T	p.P561S	Substitution - Missense	Skin
COSM267622	c.3606T>C	p.S1202S	Substitution - coding silent	Large_intestine
COSM1678410	c.5573G>T	p.R1858I	Substitution - Missense	Large_intestine
COSM961974	c.4569C>T	p.Y1523Y	Substitution - coding silent	Endometrium
COSM4879969	c.3792A>C	p.E1264D	Substitution - Missense	Prostate
COSM1180063	c.2435A>G	p.Y812C	Substitution - Missense	Prostate
COSM4830400	c.316C>G	p.Q106E	Substitution - Missense	Cervix
COSM2188300	c.3881delG	p.G1294fs*68	Deletion - Frameshift	Large_intestine
COSM4054838	c.3055T>A	p.S1019T	Substitution - Missense	Stomach
COSM3501427	c.2002C>T	p.P668S	Substitution - Missense	Skin
COSM2188275	c.5418G>A	p.A1806A	Substitution - coding silent	Large_intestine
COSM470683	c.2600C>A	p.S867*	Substitution - Nonsense	Kidney
COSM433907	c.1043G>A	p.R348K	Substitution - Missense	Breast
COSM2188333	c.1128C>T	p.I376I	Substitution - coding silent	Skin
COSM4735454	c.2130delA	p.E711fs*12	Deletion - Frameshift	Large_intestine
COSM378201	c.1716A>T	p.A572A	Substitution - coding silent	Lung
COSM4649538	c.3543G>A	p.G1181G	Substitution - coding silent	Large_intestine
COSM4854975	c.36C>T	p.F12F	Substitution - coding silent	Cervix
COSM5637056	c.3302C>T	p.S1101F	Substitution - Missense	Oesophagus
COSM1708082	c.178G>A	p.D60N	Substitution - Missense	Skin
COSM4735450	c.2993C>T	p.A998V	Substitution - Missense	Large_intestine
COSM5046261	c.365G>A	p.G122E	Substitution - Missense	Oesophagus
COSM3501432	c.1645G>A	p.E549K	Substitution - Missense	Skin
COSM3816132	c.4717G>C	p.E1573Q	Substitution - Missense	Breast
COSM212975	c.3593C>T	p.T1198I	Substitution - Missense	Breast
COSM3987968	c.657A>G	p.E219E	Substitution - coding silent	Kidney
COSM165090	c.5833G>C	p.E1945Q	Substitution - Missense	Breast
COSM21756	c.5767G>A	p.D1923N	Substitution - Missense	Skin
COSM961983	c.1076C>A	p.S359Y	Substitution - Missense	Endometrium
COSM3370175	c.2926G>T	p.G976W	Substitution - Missense	Thyroid
COSM3501422	c.3729C>T	p.I1243I	Substitution - coding silent	Skin
COSM1723750	c.4667-6C>T	p.?	Unknown	Skin
COSM5940558	c.1120C>T	p.P374S	Substitution - Missense	Skin
COSM5600714	c.3266C>T	p.P1089L	Substitution - Missense	Skin
COSM4613394	c.3050delA	p.N1017fs*20	Deletion - Frameshift	Prostate
COSM1562919	c.3712C>T	p.R1238C	Substitution - Missense	Upper_aerodigestive_tract
COSM3361408	c.2924C>T	p.S975F	Substitution - Missense	Kidney
COSM3816140	c.1904C>T	p.S635F	Substitution - Missense	Breast
COSM258232	c.2731G>T	p.E911*	Substitution - Nonsense	Large_intestine
COSM3401744	c.357-1G>C	p.?	Unknown	Central_nervous_system
COSM268528	c.5197G>A	p.A1733T	Substitution - Missense	Large_intestine
COSM5966804	c.3145C>T	p.R1049*	Substitution - Nonsense	Adrenal_gland
COSM4623113	c.4697G>T	p.G1566V	Substitution - Missense	Large_intestine
COSM106336	c.3549T>A	p.S1183R	Substitution - Missense	Skin
COSM129864	c.850C>G	p.L284V	Substitution - Missense	Upper_aerodigestive_tract
COSM1373030	c.163G>T	p.E55*	Substitution - Nonsense	Large_intestine
COSM5913720	c.1259C>T	p.P420L	Substitution - Missense	Skin
COSM700502	c.3517A>T	p.T1173S	Substitution - Missense	Lung
COSM961968	c.5455C>T	p.L1819F	Substitution - Missense	Endometrium
COSM5717798	c.4050C>T	p.A1350A	Substitution - coding silent	Skin
COSM4753949	c.5417C>T	p.A1806V	Substitution - Missense	Stomach
COSM84287	c.4903T>C	p.S1635P	Substitution - Missense	Pancreas
COSM3816135	c.2821+5G>A	p.?	Unknown	Breast
COSM1735775	c.2702-4_2702-3insT	p.?	Unknown	Central_nervous_system
COSM5722305	c.1809T>C	p.G603G	Substitution - coding silent	Skin
COSM5886899	c.5291-1G>A	p.?	Unknown	Skin
COSM470687	c.632A>G	p.D211G	Substitution - Missense	Kidney
COSM1608394	c.5291-8delT	p.?	Unknown	Biliary_tract
COSM1664643	c.5855T>C	p.I1952T	Substitution - Missense	Kidney
COSM5895315	c.2702-4delT	p.?	Unknown	Skin
COSM5984601	c.3796G>C	p.E1266Q	Substitution - Missense	Upper_aerodigestive_tract
COSM1735775	c.2702-4_2702-3insT	p.?	Unknown	Oesophagus
COSM3501435	c.878A>T	p.K293M	Substitution - Missense	Skin
COSM1640247	c.1375-2A>G	p.?	Unknown	Stomach
COSM1230113	c.5812C>T	p.Q1938*	Substitution - Nonsense	Large_intestine
COSM3501426	c.2261C>T	p.S754F	Substitution - Missense	Skin
COSM5691245	c.2742C>A	p.I914I	Substitution - coding silent	Soft_tissue
COSM5895315	c.2702-4delT	p.?	Unknown	Upper_aerodigestive_tract
COSM5243171	c.874C>T	p.Q292*	Substitution - Nonsense	Skin
COSM3501419	c.4186C>T	p.R1396C	Substitution - Missense	Skin
COSM5980740	c.5593C>T	p.R1865C	Substitution - Missense	Upper_aerodigestive_tract
COSM961976	c.4026C>T	p.S1342S	Substitution - coding silent	Endometrium
COSM5971427	c.685G>T	p.A229S	Substitution - Missense	Upper_aerodigestive_tract
COSM5725541	c.4650T>G	p.D1550E	Substitution - Missense	Skin
COSM5436369	c.2492C>T	p.S831L	Substitution - Missense	Oesophagus
COSM4839612	c.5218A>G	p.T1740A	Substitution - Missense	Cervix
COSM3420315	c.1494G>T	p.K498N	Substitution - Missense	Large_intestine
COSM223758	c.3586G>A	p.V1196I	Substitution - Missense	Skin
COSM223757	c.5771C>T	p.P1924L	Substitution - Missense	Skin
COSM4928385	c.1682C>G	p.P561R	Substitution - Missense	Liver
COSM3361407	c.4019A>G	p.K1340R	Substitution - Missense	Kidney
COSM961971	c.4921G>A	p.A1641T	Substitution - Missense	Endometrium
COSM4949329	c.2047A>T	p.N683Y	Substitution - Missense	Liver
COSM3700959	c.1625A>T	p.N542I	Substitution - Missense	Liver
COSM4826843	c.2264G>T	p.S755I	Substitution - Missense	Cervix
COSM3754332	c.1234G>A	p.G412S	Substitution - Missense	Soft_tissue
COSM4973766	c.1498T>A	p.S500T	Substitution - Missense	Oesophagus
COSM3754330	c.3406A>C	p.K1136Q	Substitution - Missense	Pancreas
COSM4735442	c.4652A>G	p.E1551G	Substitution - Missense	Large_intestine
COSM3754332	c.1234G>A	p.G412S	Substitution - Missense	Large_intestine
COSM3370174	c.4338C>A	p.S1446S	Substitution - coding silent	Thyroid
COSM3754331	c.2487T>C	p.D829D	Substitution - coding silent	Large_intestine
COSM4150948	c.3358A>G	p.M1120V	Substitution - Missense	Kidney
COSM3678193	c.1234G>C	p.G412R	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM4791668	c.3814-1G>T	p.?	Unknown	Liver
COSM3672050	c.4038C>A	p.P1346P	Substitution - coding silent	Prostate
COSM961987	c.14G>A	p.G5E	Substitution - Missense	Skin
COSM416925	c.3493G>A	p.E1165K	Substitution - Missense	Urinary_tract
COSM277766	c.5003G>T	p.R1668I	Substitution - Missense	Large_intestine
COSM167296	c.5432G>A	p.R1811Q	Substitution - Missense	Cervix
COSM3956640	c.5243G>A	p.R1748H	Substitution - Missense	Lung
COSM3501417	c.4362T>A	p.A1454A	Substitution - coding silent	Skin
COSM3501416	c.4396C>T	p.P1466S	Substitution - Missense	Skin
COSM3754330	c.3406A>C	p.K1136Q	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM3987964	c.3651C>T	p.L1217L	Substitution - coding silent	Kidney
COSM3816138	c.2185C>G	p.Q729E	Substitution - Missense	Breast
COSM242012	c.4639C>G	p.L1547V	Substitution - Missense	Prostate
COSM961969	c.5050C>T	p.R1684C	Substitution - Missense	Endometrium
COSM3754331	c.2487T>C	p.D829D	Substitution - coding silent	Haematopoietic_and_lymphoid_tissue
COSM3816142	c.616A>T	p.R206W	Substitution - Missense	Breast
COSM1230119	c.2044G>T	p.E682*	Substitution - Nonsense	Large_intestine
COSM3981514	c.1786G>T	p.D596Y	Substitution - Missense	Ovary
COSM5383360	c.1258_1259CC>TT	p.P420F	Substitution - Missense	Skin
COSM416924	c.337C>A	p.Q113K	Substitution - Missense	Urinary_tract
COSM3816131	c.4994C>T	p.S1665L	Substitution - Missense	Breast
COSM470682	c.2630C>G	p.S877*	Substitution - Nonsense	Kidney
COSM264147	c.2209G>T	p.E737*	Substitution - Nonsense	Endometrium
COSM4187730	c.3814G>A	p.E1272K	Substitution - Missense	Kidney
COSM3690406	c.2994G>A	p.A998A	Substitution - coding silent	Large_intestine
COSM3754329	c.5058T>A	p.S1686S	Substitution - coding silent	Thyroid
COSM32419	c.4747C>T	p.R1583*	Substitution - Nonsense	Large_intestine
COSM961981	c.1746T>C	p.N582N	Substitution - coding silent	Endometrium
COSM3501424	c.2352C>T	p.S784S	Substitution - coding silent	Skin
COSM5383362	c.568G>A	p.V190M	Substitution - Missense	Skin
COSM2188341	c.919T>C	p.F307L	Substitution - Missense	Large_intestine
COSM4891047	c.5607C>A	p.F1869L	Substitution - Missense	Upper_aerodigestive_tract
COSM3744615	c.1059C>G	p.D353E	Substitution - Missense	Liver
COSM1188991	c.3611A>T	p.E1204V	Substitution - Missense	Lung
COSM4735438	c.5029C>T	p.R1677W	Substitution - Missense	Large_intestine
COSM1230116	c.4198C>T	p.R1400*	Substitution - Nonsense	Large_intestine
COSM5692560	c.380C>G	p.S127C	Substitution - Missense	Soft_tissue
COSM5722303	c.4001C>T	p.A1334V	Substitution - Missense	Skin
COSM3754332	c.1234G>A	p.G412S	Substitution - Missense	Soft_tissue
COSM3999533	c.177+7G>A	p.?	Unknown	Haematopoietic_and_lymphoid_tissue
COSM5509502	c.933T>C	p.N311N	Substitution - coding silent	Biliary_tract
COSM5005196	c.1111C>T	p.R371*	Substitution - Nonsense	Haematopoietic_and_lymphoid_tissue
COSM5980742	c.730A>G	p.K244E	Substitution - Missense	Upper_aerodigestive_tract
COSM3754332	c.1234G>A	p.G412S	Substitution - Missense	Soft_tissue
COSM3794179	c.2926G>A	p.G976R	Substitution - Missense	Urinary_tract
COSM1373024	c.2130_2131insA	p.E711fs*9	Insertion - Frameshift	Large_intestine
COSM961970	c.4970C>T	p.P1657L	Substitution - Missense	Endometrium
COSM3754329	c.5058T>A	p.S1686S	Substitution - coding silent	Large_intestine
COSM3816134	c.4459G>A	p.V1487I	Substitution - Missense	Breast
COSM4054829	c.5741T>C	p.L1914S	Substitution - Missense	Stomach
COSM1749157	c.3056C>T	p.S1019F	Substitution - Missense	Urinary_tract
COSM3816136	c.2811T>C	p.S937S	Substitution - coding silent	Breast
COSM3744615	c.1059C>G	p.D353E	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM5722305	c.1809T>C	p.G603G	Substitution - coding silent	Skin
COSM4485596	c.2935C>T	p.P979S	Substitution - Missense	Skin
COSM4578266	c.2919G>T	p.G973G	Substitution - coding silent	Bone
COSM5226336	c.5388_5389insT	p.N1797fs*1	Insertion - Frameshift	Breast
COSM1373022	c.3219G>T	p.E1073D	Substitution - Missense	Large_intestine
COSM1579532	c.4510G>T	p.G1504W	Substitution - Missense	Lung
COSM3887016	c.1516C>T	p.L506L	Substitution - coding silent	Skin
COSM4753955	c.2975T>G	p.V992G	Substitution - Missense	Stomach
COSM4514563	c.964C>T	p.P322S	Substitution - Missense	Skin
COSM3969119	c.3820G>T	p.E1274*	Substitution - Nonsense	Central_nervous_system
COSM4753961	c.472C>T	p.L158F	Substitution - Missense	Stomach
COSM3501431	c.1648C>T	p.P550S	Substitution - Missense	Skin
COSM253866	c.2689G>T	p.E897*	Substitution - Nonsense	Urinary_tract
COSM1658989	c.3854C>G	p.T1285S	Substitution - Missense	Salivary_gland
COSM4054833	c.4312C>A	p.R1438S	Substitution - Missense	Stomach
COSM4849568	c.2967G>A	p.M989I	Substitution - Missense	Cervix
COSM1708081	c.989C>T	p.S330F	Substitution - Missense	Skin
COSM961982	c.1663C>G	p.L555V	Substitution - Missense	Endometrium
COSM4467933	c.1500C>T	p.S500S	Substitution - coding silent	Skin
COSM285874	c.4723G>T	p.E1575*	Substitution - Nonsense	Large_intestine
COSM1608394	c.5291-8delT	p.?	Unknown	Liver
COSM4877135	c.4819G>A	p.A1607T	Substitution - Missense	Prostate
COSM5054302	c.5820T>C	p.P1940P	Substitution - coding silent	Stomach
COSM4393406	c.5431C>T	p.R1811*	Substitution - Nonsense	Prostate
COSM4949329	c.2047A>T	p.N683Y	Substitution - Missense	Liver
COSM3501433	c.1356C>T	p.S452S	Substitution - coding silent	Skin
COSM4427895	c.2551C>T	p.Q851*	Substitution - Nonsense	Oesophagus
COSM700500	c.1216C>T	p.Q406*	Substitution - Nonsense	Lung
COSM1708080	c.2489C>T	p.S830F	Substitution - Missense	Skin
COSM5722303	c.4001C>T	p.A1334V	Substitution - Missense	Skin
COSM5653137	c.1289_1291delCAC	p.P430delP	Deletion - In frame	Haematopoietic_and_lymphoid_tissue
COSM1268373	c.221G>A	p.G74E	Substitution - Missense	Stomach
COSM336045	c.4927A>G	p.S1643G	Substitution - Missense	Lung
COSM3754331	c.2487T>C	p.D829D	Substitution - coding silent	Haematopoietic_and_lymphoid_tissue
COSM961981	c.1746T>C	p.N582N	Substitution - coding silent	Endometrium
COSM3501436	c.471C>T	p.S157S	Substitution - coding silent	Skin
COSM3754332	c.1234G>A	p.G412S	Substitution - Missense	Large_intestine
COSM396919	c.5497G>A	p.D1833N	Substitution - Missense	Lung
COSM4054836	c.3902A>C	p.D1301A	Substitution - Missense	Stomach
COSM264146	c.2300G>T	p.R767I	Substitution - Missense	Large_intestine
COSM2152386	c.1971G>A	p.E657E	Substitution - coding silent	Central_nervous_system
COSM3501415	c.4401C>T	p.F1467F	Substitution - coding silent	Skin
COSM1678410	c.5573G>T	p.R1858I	Substitution - Missense	Large_intestine
COSM4613394	c.3050delA	p.N1017fs*20	Deletion - Frameshift	Large_intestine
COSM470686	c.1222A>G	p.K408E	Substitution - Missense	Kidney
COSM398714	c.484+1G>A	p.?	Unknown	Lung
COSM5600714	c.3266C>T	p.P1089L	Substitution - Missense	Skin
COSM3744614	c.4541A>C	p.K1514T	Substitution - Missense	Liver
COSM5705877	c.4627G>T	p.E1543*	Substitution - Nonsense	Haematopoietic_and_lymphoid_tissue
COSM961986	c.256G>T	p.E86*	Substitution - Nonsense	Endometrium
COSM4891012	c.4181C>T	p.T1394M	Substitution - Missense	Upper_aerodigestive_tract
COSM3816130	c.5348G>C	p.G1783A	Substitution - Missense	Breast
COSM5722303	c.4001C>T	p.A1334V	Substitution - Missense	Skin
COSM4777845	c.1842_1843insG	p.V615fs*4	Insertion - Frameshift	Prostate
COSM4772829	c.5797_5806del10	p.C1933fs*12	Deletion - Frameshift	Stomach
COSM5383358	c.1963C>T	p.P655S	Substitution - Missense	Skin
COSM5452040	c.5093_5094delAG	p.E1698fs*6	Deletion - Frameshift	Large_intestine
COSM253866	c.2689G>T	p.E897*	Substitution - Nonsense	Urinary_tract
COSM264147	c.2209G>T	p.E737*	Substitution - Nonsense	Large_intestine
COSM4834823	c.1355C>G	p.S452C	Substitution - Missense	Cervix
COSM4148777	c.5026G>C	p.E1676Q	Substitution - Missense	Thyroid
COSM470684	c.2447T>G	p.L816R	Substitution - Missense	Kidney
COSM96921	c.4957_4960ATCA>TCCT	p.I1653_T1654>SS	Complex - compound substitution	Lung
COSM4880000	c.3752C>T	p.T1251I	Substitution - Missense	Prostate
COSM5725541	c.4650T>G	p.D1550E	Substitution - Missense	Skin
COSM1562919	c.3712C>T	p.R1238C	Substitution - Missense	Large_intestine
COSM5616816	c.324T>A	p.I108I	Substitution - coding silent	Lung
COSM1230117	c.5867G>T	p.R1956I	Substitution - Missense	Large_intestine
COSM961979	c.1970_1972delAGG	p.E657delE	Deletion - In frame	Endometrium
COSM2188305	c.3687G>A	p.Q1229Q	Substitution - coding silent	Large_intestine
COSM3501420	c.3961C>T	p.L1321F	Substitution - Missense	Skin
COSM5600714	c.3266C>T	p.P1089L	Substitution - Missense	Skin
COSM5929618	c.1277C>T	p.S426F	Substitution - Missense	Skin
COSM5454349	c.217C>T	p.R73*	Substitution - Nonsense	Large_intestine
COSM277766	c.5003G>T	p.R1668I	Substitution - Missense	Breast
COSM3786516	c.5544G>T	p.L1848F	Substitution - Missense	Pancreas
COSM961977	c.3001G>T	p.E1001*	Substitution - Nonsense	Endometrium
COSM233632	c.2062C>T	p.P688S	Substitution - Missense	Skin
COSM5600714	c.3266C>T	p.P1089L	Substitution - Missense	Skin
COSM78688	c.760C>T	p.P254S	Substitution - Missense	Ovary
COSM1230115	c.3416C>A	p.P1139H	Substitution - Missense	Large_intestine
COSM6001645	c.5488T>G	p.W1830G	Substitution - Missense	Prostate
COSM3969118	c.5575A>G	p.I1859V	Substitution - Missense	Central_nervous_system
COSM285875	c.445G>T	p.D149Y	Substitution - Missense	Large_intestine
COSM4506114	c.695C>T	p.S232F	Substitution - Missense	Skin
COSM4963469	c.1638G>C	p.E546D	Substitution - Missense	Pancreas
COSM4607085	c.4665A>T	p.A1555A	Substitution - coding silent	Adrenal_gland
COSM961987	c.14G>A	p.G5E	Substitution - Missense	Endometrium
COSM5046703	c.4532G>A	p.G1511E	Substitution - Missense	Oesophagus
COSM3501437	c.273C>T	p.D91D	Substitution - coding silent	Skin
COSM3769863	c.5765C>A	p.T1922K	Substitution - Missense	Soft_tissue
COSM3754332	c.1234G>A	p.G412S	Substitution - Missense	Soft_tissue
COSM4540518	c.2839G>A	p.E947K	Substitution - Missense	Skin
COSM277767	c.3146G>A	p.R1049Q	Substitution - Missense	Large_intestine
COSM3987967	c.1643C>T	p.T548M	Substitution - Missense	Kidney
COSM4054830	c.5528A>G	p.Y1843C	Substitution - Missense	Stomach
COSM4390743	c.5448C>T	p.F1816F	Substitution - coding silent	Breast
COSM2152386	c.1971G>A	p.E657E	Substitution - coding silent	Central_nervous_system
COSM5895240	c.2702-3_2702-2insT	p.?	Unknown	Skin
COSM5692562	c.361C>T	p.L121L	Substitution - coding silent	Soft_tissue
COSM1230118	c.2680A>C	p.S894R	Substitution - Missense	Large_intestine
COSM4054831	c.5291-2A>G	p.?	Unknown	Stomach
COSM961975	c.4324C>T	p.R1442*	Substitution - Nonsense	Endometrium
COSM5964755	c.1317C>T	p.S439S	Substitution - coding silent	Breast
COSM1268375	c.3080C>G	p.A1027G	Substitution - Missense	Oesophagus
COSM3956641	c.1180A>T	p.T394S	Substitution - Missense	Lung
COSM248973	c.4545T>G	p.Y1515*	Substitution - Nonsense	Pancreas
COSM961978	c.2149G>T	p.E717*	Substitution - Nonsense	Endometrium
COSM5428822	c.2198T>C	p.I733T	Substitution - Missense	Oesophagus
COSM4735434	c.5774C>T	p.S1925L	Substitution - Missense	Large_intestine
COSM3887017	c.1448C>T	p.S483L	Substitution - Missense	Skin
COSM316086	c.1294G>A	p.A432T	Substitution - Missense	Lung
COSM3744615	c.1059C>G	p.D353E	Substitution - Missense	Large_intestine
COSM326734	c.3607G>T	p.G1203C	Substitution - Missense	Lung
COSM1373030	c.163G>T	p.E55*	Substitution - Nonsense	Large_intestine
COSM3501423	c.2501C>T	p.S834F	Substitution - Missense	Skin
COSM4735461	c.211G>A	p.E71K	Substitution - Missense	Large_intestine
COSM3386884	c.959C>G	p.S320C	Substitution - Missense	Pancreas
COSM1734519	c.5030G>A	p.R1677Q	Substitution - Missense	Pancreas
COSM3754332	c.1234G>A	p.G412S	Substitution - Missense	Soft_tissue
COSM5740315	c.3193T>A	p.F1065I	Substitution - Missense	Small_intestine
COSM277766	c.5003G>T	p.R1668I	Substitution - Missense	Endometrium
COSM433904	c.5625C>G	p.L1875L	Substitution - coding silent	Breast
COSM3386883	c.1143C>A	p.P381P	Substitution - coding silent	Pancreas
COSM961985	c.412G>T	p.E138*	Substitution - Nonsense	Endometrium
COSM4970814	c.4667-28_4667-7del22	p.?	Unknown	Central_nervous_system
COSM270378	c.5888C>T	p.P1963L	Substitution - Missense	Large_intestine
COSM4735446	c.3667G>T	p.E1223*	Substitution - Nonsense	Large_intestine
COSM268528	c.5197G>A	p.A1733T	Substitution - Missense	Upper_aerodigestive_tract
COSM700503	c.4027G>T	p.G1343W	Substitution - Missense	Lung
COSM5895315	c.2702-4delT	p.?	Unknown	Skin
COSM1723750	c.4667-6C>T	p.?	Unknown	Skin
COSM700505	c.4994C>G	p.S1665*	Substitution - Nonsense	Lung
COSM3501425	c.2291C>T	p.P764L	Substitution - Missense	Skin
COSM4735440	c.4655A>G	p.Y1552C	Substitution - Missense	Large_intestine
COSM5722303	c.4001C>T	p.A1334V	Substitution - Missense	Skin
COSM1493434	c.2185C>T	p.Q729*	Substitution - Nonsense	Kidney
COSM1230116	c.4198C>T	p.R1400*	Substitution - Nonsense	Large_intestine
COSM3794181	c.40C>T	p.Q14*	Substitution - Nonsense	Urinary_tract
COSM4963469	c.1638G>C	p.E546D	Substitution - Missense	Pancreas
COSM3501434	c.1329C>T	p.F443F	Substitution - coding silent	Skin
COSM4963476	c.1015C>G	p.L339V	Substitution - Missense	Pancreas
COSM5049716	c.4666G>A	p.G1556R	Substitution - Missense	Oesophagus
COSM5728518	c.1816G>A	p.G606S	Substitution - Missense	Skin
COSM1373025	c.1988A>G	p.E663G	Substitution - Missense	Large_intestine
COSM2188320	c.2130A>C	p.K710N	Substitution - Missense	Large_intestine
COSM3816139	c.1942A>G	p.M648V	Substitution - Missense	Breast
COSM138961	c.4490C>T	p.S1497F	Substitution - Missense	Skin
COSM3501418	c.4199G>A	p.R1400Q	Substitution - Missense	Skin
COSM4735444	c.3941G>A	p.R1314H	Substitution - Missense	Large_intestine
COSM5490875	c.4468C>T	p.R1490C	Substitution - Missense	Biliary_tract
COSM4054832	c.5051G>A	p.R1684H	Substitution - Missense	Stomach
COSM2188328	c.1440G>A	p.M480I	Substitution - Missense	Stomach
COSM4497789	c.5035C>T	p.P1679S	Substitution - Missense	Skin
COSM700499	c.860G>T	p.S287I	Substitution - Missense	Lung
COSM5363086	c.1731A>G	p.V577V	Substitution - coding silent	Large_intestine
COSM5454349	c.217C>T	p.R73*	Substitution - Nonsense	Breast
COSM1740224	c.1297T>C	p.S433P	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM21756	c.5767G>A	p.D1923N	Substitution - Missense	Skin
COSM3377570	c.5181C>G	p.T1727T	Substitution - coding silent	Pancreas
COSM3754332	c.1234G>A	p.G412S	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM5717798	c.4050C>T	p.A1350A	Substitution - coding silent	Skin
COSM4917019	c.5587C>A	p.Q1863K	Substitution - Missense	Liver
COSM1579532	c.4510G>T	p.G1504W	Substitution - Missense	Stomach
COSM4467933	c.1500C>T	p.S500S	Substitution - coding silent	Skin
COSM3754330	c.3406A>C	p.K1136Q	Substitution - Missense	Large_intestine
COSM5722305	c.1809T>C	p.G603G	Substitution - coding silent	Skin
COSM349033	c.3128G>T	p.R1043M	Substitution - Missense	Lung
COSM227115	c.4439C>T	p.S1480F	Substitution - Missense	Skin
COSM961981	c.1746T>C	p.N582N	Substitution - coding silent	Endometrium
COSM229269	c.1499C>T	p.S500F	Substitution - Missense	Skin
COSM1580343	c.3026-1G>A	p.?	Unknown	Central_nervous_system
COSM5600714	c.3266C>T	p.P1089L	Substitution - Missense	Skin
COSM285876	c.1071-1G>T	p.?	Unknown	Large_intestine
COSM3999533	c.177+7G>A	p.?	Unknown	Oesophagus
COSM4401144	c.2916A>C	p.K972N	Substitution - Missense	Skin
COSM1268374	c.1402G>T	p.E468*	Substitution - Nonsense	Oesophagus
COSM5456485	c.4635G>A	p.T1545T	Substitution - coding silent	Large_intestine
COSM5597738	c.1604G>A	p.R535K	Substitution - Missense	Skin
COSM2188303	c.3770T>C	p.V1257A	Substitution - Missense	Large_intestine
COSM5667467	c.479C>T	p.A160V	Substitution - Missense	Soft_tissue
COSM258233	c.847G>T	p.E283*	Substitution - Nonsense	Large_intestine
COSM3501427	c.2002C>T	p.P668S	Substitution - Missense	Skin
COSM4432309	c.4313G>A	p.R1438H	Substitution - Missense	Oesophagus
COSM961980	c.1887G>A	p.P629P	Substitution - coding silent	Endometrium
COSM6001722	c.320T>C	p.V107A	Substitution - Missense	Prostate
COSM5645847	c.3590_3591insC	p.Q1197fs*3	Insertion - Frameshift	Oesophagus
COSM3744615	c.1059C>G	p.D353E	Substitution - Missense	Large_intestine
COSM5717798	c.4050C>T	p.A1350A	Substitution - coding silent	Skin
COSM961972	c.4788G>C	p.L1596L	Substitution - coding silent	Endometrium
COSM4492871	c.4037C>T	p.P1346L	Substitution - Missense	Skin
COSM961984	c.751G>T	p.E251*	Substitution - Nonsense	Endometrium
COSM4825977	c.3376G>C	p.E1126Q	Substitution - Missense	Cervix
COSM1230114	c.5449C>A	p.L1817M	Substitution - Missense	Large_intestine
COSM1678412	c.2810G>A	p.S937N	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM3754332	c.1234G>A	p.G412S	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM4778349	c.2960T>C	p.L987P	Substitution - Missense	Liver
COSM4856274	c.2635G>A	p.A879T	Substitution - Missense	Cervix
COSM5764441	c.2724G>T	p.L908F	Substitution - Missense	Large_intestine
COSM433905	c.4850T>G	p.I1617S	Substitution - Missense	Breast
COSM4735452	c.2176G>T	p.D726Y	Substitution - Missense	Large_intestine
COSM3816133	c.4673T>G	p.V1558G	Substitution - Missense	Breast
COSM4523419	c.1198G>A	p.E400K	Substitution - Missense	Skin
COSM3678192	c.2487T>G	p.D829E	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM3501421	c.3917C>T	p.S1306F	Substitution - Missense	Skin
COSM5786038	c.1374+1G>A	p.?	Unknown	Breast
COSM3956640	c.5243G>A	p.R1748H	Substitution - Missense	Skin
COSM3501430	c.1900C>T	p.R634*	Substitution - Nonsense	Skin
COSM3816141	c.1087G>T	p.V363F	Substitution - Missense	Breast
COSM3501429	c.1999A>T	p.I667F	Substitution - Missense	Skin
COSM4735448	c.3083G>T	p.S1028I	Substitution - Missense	Large_intestine
COSM2188354	c.115C>T	p.H39Y	Substitution - Missense	Large_intestine
COSM4895822	c.1003C>T	p.P335S	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM4791668	c.3814-1G>T	p.?	Unknown	Liver
COSM3816129	c.5451G>T	p.L1817L	Substitution - coding silent	Breast
COSM5582833	c.3203C>T	p.S1068F	Substitution - Missense	Skin
COSM5940560	c.113C>T	p.S38F	Substitution - Missense	Skin
COSM167903	c.670G>A	p.E224K	Substitution - Missense	Endometrium
COSM5754694	c.3574C>T	p.Q1192*	Substitution - Nonsense	Large_intestine
COSM4735436	c.5273G>T	p.S1758I	Substitution - Missense	Large_intestine
COSM3665092	c.2238G>A	p.W746*	Substitution - Nonsense	Oesophagus
COSM2188354	c.115C>T	p.H39Y	Substitution - Missense	Large_intestine
COSM4895822	c.1003C>T	p.P335S	Substitution - Missense	Skin
COSM1301145	c.4544A>C	p.Y1515S	Substitution - Missense	Urinary_tract
COSM5595471	c.3480C>T	p.S1160S	Substitution - coding silent	Skin
COSM1608395	c.1070+4A>C	p.?	Unknown	Liver
COSM4414552	c.2554C>T	p.Q852*	Substitution - Nonsense	Kidney
COSM5725541	c.4650T>G	p.D1550E	Substitution - Missense	Skin
COSM5054306	c.5283_5285delAGA	p.E1764delE	Deletion - In frame	Stomach
COSM2188354	c.115C>T	p.H39Y	Substitution - Missense	Large_intestine
COSM3370176	c.2886G>A	p.E962E	Substitution - coding silent	Thyroid
COSM111694	c.992_997delTGGCTT	p.L331_A332delLA	Deletion - In frame	Ovary
COSM961973	c.4733G>T	p.R1578I	Substitution - Missense	Endometrium
COSM4566027	c.2889_2890CC>TT	p.H964Y	Substitution - Missense	Skin
COSM4735457	c.1604G>T	p.R535I	Substitution - Missense	Large_intestine
COSM2188260	c.5867G>A	p.R1956K	Substitution - Missense	Bone
COSM26978	c.4661G>A	p.S1554N	Substitution - Missense	Kidney
COSM4963476	c.1015C>G	p.L339V	Substitution - Missense	Pancreas
COSM4054839	c.2300G>A	p.R767K	Substitution - Missense	Stomach
COSM3744615	c.1059C>G	p.D353E	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM116472	c.3692C>T	p.P1231L	Substitution - Missense	Ovary
COSM1749157	c.3056C>T	p.S1019F	Substitution - Missense	Urinary_tract
COSM433906	c.3483G>C	p.L1161F	Substitution - Missense	Breast
COSM3726649	c.857A>G	p.E286G	Substitution - Missense	Lung
COSM4054840	c.2036T>A	p.L679H	Substitution - Missense	Stomach
COSM5772500	c.4523G>A	p.R1508Q	Substitution - Missense	Breast
COSM1640246	c.5407C>T	p.L1803F	Substitution - Missense	Stomach
COSM5054304	c.5544G>A	p.L1848L	Substitution - coding silent	Stomach
COSM3987967	c.1643C>T	p.T548M	Substitution - Missense	Small_intestine
COSM4054837	c.3420T>C	p.S1140S	Substitution - coding silent	Stomach
COSM3987965	c.3030T>C	p.P1010P	Substitution - coding silent	Kidney
COSM1678411	c.4904C>T	p.S1635F	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM961967	c.5732-1G>T	p.?	Unknown	Endometrium
COSM3501428	c.2001C>A	p.I667I	Substitution - coding silent	Skin
COSM3501430	c.1900C>T	p.R634*	Substitution - Nonsense	Large_intestine
COSM470685	c.2189A>C	p.K730T	Substitution - Missense	Kidney
COSM961974	c.4569C>T	p.Y1523Y	Substitution - coding silent	Large_intestine
COSM1493435	c.5043G>A	p.K1681K	Substitution - coding silent	Kidney
COSM3794180	c.2742C>T	p.I914I	Substitution - coding silent	Urinary_tract

> Text Mining based Variations

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PMID	Variation	Cancer	Evidence
28082821	Mutation	Colorectal Carcinoma	Additional genetic analyses revealed a frameshift truncating mutation of the TP53BP1 gene in the patient who progressed.

Summary
Symbol	TP53BP1
Name	tumor protein p53 binding protein 1
Aliases	53BP1; p202; TDRD30; tumor protein p53-binding protein, 1; p53BP1; p53-binding protein 1; tumor protein 53-b ......
Location	15q15.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Post-translational modification (PTM)

> Post-translational modification (PTM)

[ TOP ]

Filter By:

Uniprot ID	Position	Amino Acid	Description	Upstream Enzyme	Affected By Mutation	Amino Acid Sequence Variant
Q12888	63	S	Phosphoserine	-	No	None detected
Q12888	105	S	Phosphoserine	-	No	None detected
Q12888	124	S	Phosphoserine	-	No	None detected
Q12888	166	S	Phosphoserine	-	No	None detected
Q12888	176	S	Phosphoserine	-	No	None detected
Q12888	178	S	Phosphoserine	-	No	None detected
Q12888	222	S	Phosphoserine	-	No	None detected
Q12888	265	S	Phosphoserine	-	No	None detected
Q12888	294	S	Phosphoserine	-	No	None detected
Q12888	302	T	Phosphothreonine	-	No	None detected
Q12888	366	S	Phosphoserine	-	No	None detected
Q12888	380	S	Phosphoserine	-	No	None detected
Q12888	395	S	Phosphoserine	-	No	None detected
Q12888	398	S	Phosphoserine	-	No	None detected
Q12888	452	S	Phosphoserine	-	Yes	p.S452C (cancer: CESC)
Q12888	464	S	Phosphoserine	-	No	None detected
Q12888	500	S	Phosphoserine	-	No	None detected
Q12888	507	S	Phosphoserine	-	No	None detected
Q12888	518	S	Phosphoserine	-	No	None detected
Q12888	523	S	Phosphoserine	-	No	None detected
Q12888	525	S	Phosphoserine	-	No	None detected
Q12888	543	T	Phosphothreonine	-	No	None detected
Q12888	548	T	Phosphothreonine	-	No	None detected
Q12888	552	S	Phosphoserine	-	No	None detected
Q12888	566	S	Phosphoserine	-	No	None detected
Q12888	580	S	Phosphoserine	-	No	None detected
Q12888	630	S	Phosphoserine	-	No	None detected
Q12888	635	S	Phosphoserine	-	Yes	p.S635F (cancer: BRCA)
Q12888	639	S	Phosphoserine	-	No	None detected
Q12888	640	S	Phosphoserine	-	No	None detected
Q12888	692	S	Phosphoserine	-	No	None detected
Q12888	724	S	Phosphoserine	-	No	None detected
Q12888	727	S	Phosphoserine	-	No	None detected
Q12888	771	S	Phosphoserine	-	No	None detected
Q12888	809	S	Phosphoserine	-	No	None detected
Q12888	830	S	Phosphoserine	-	No	None detected
Q12888	831	S	Phosphoserine	-	Yes	p.S831fs (cancer: STAD)
Q12888	834	S	Phosphoserine	-	Yes	p.S834F (cancer: SKCM)
Q12888	855	T	Phosphothreonine	-	No	None detected
Q12888	922	T	Phosphothreonine	-	No	None detected
Q12888	970	S	Phosphoserine	-	No	None detected
Q12888	975	S	Phosphoserine	-	Yes	p.S975F (cancer: KIRC)
Q12888	1028	S	Phosphoserine	-	No	None detected
Q12888	1056	T	Phosphothreonine	-	No	None detected
Q12888	1068	S	Phosphoserine	-	No	None detected
Q12888	1086	S	Phosphoserine	-	No	None detected
Q12888	1094	S	Phosphoserine	-	No	None detected
Q12888	1101	S	Phosphoserine	-	Yes	p.S1101Y (cancer: STAD)
Q12888	1114	S	Phosphoserine	-	No	None detected
Q12888	1148	S	Phosphoserine	-	No	None detected
Q12888	1214	T	Phosphothreonine	-	No	None detected
Q12888	1216	S	Phosphoserine	-	No	None detected
Q12888	1219	S	Phosphoserine	-	No	None detected
Q12888	1317	S	Phosphoserine	-	No	None detected
Q12888	1342	S	Phosphoserine	-	No	None detected
Q12888	1355	R	Omega-N-methylarginine	-	Yes	p.R1355* (cancer: STAD)
Q12888	1362	S	Phosphoserine	-	No	None detected
Q12888	1368	S	Phosphoserine	-	No	None detected
Q12888	1372	T	Phosphothreonine	-	No	None detected
Q12888	1426	S	Phosphoserine	-	No	None detected
Q12888	1430	S	Phosphoserine	-	Yes	p.S1430P (cancer: COAD)
Q12888	1460	S	Phosphoserine	-	No	None detected
Q12888	1462	S	Phosphoserine	-	No	None detected
Q12888	1474	S	Phosphoserine	-	No	None detected
Q12888	1609	T	Phosphothreonine	-	No	None detected
Q12888	1618	S	Phosphoserine	-	No	None detected
Q12888	1631	S	Phosphoserine	-	No	None detected
Q12888	1635	S	Phosphoserine	-	No	None detected
Q12888	1638	T	Phosphothreonine	-	No	None detected
Q12888	1648	T	Phosphothreonine	-	No	None detected
Q12888	1656	S	Phosphoserine	-	No	None detected
Q12888	1673	S	Phosphoserine	-	No	None detected
Q12888	1678	S	Phosphoserine	-	No	None detected
Q12888	1701	S	Phosphoserine	-	No	None detected
Q12888	1759	S	Phosphoserine	-	No	None detected
Q12888	1778	S	Phosphoserine	-	No	None detected

Summary
Symbol	TP53BP1
Name	tumor protein p53 binding protein 1
Aliases	53BP1; p202; TDRD30; tumor protein p53-binding protein, 1; p53BP1; p53-binding protein 1; tumor protein 53-b ......
Location	15q15.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Expression analysis in primary tumor tissue from TCGA > Expression level in cancer cell line from CCLE > Expression level in human normal tissue from HPA > Text mining based expression change

> The Cancer Genome Atlas (TCGA)

[ TOP ]

Differential expression analysis for cancers with more than 10 normal samples

Cancer	Full Name	# N	# T	Median (N)	Median (T)	LogFC	Adj. P	Status
BLCA	Bladder urothelial carcinoma	19	408	5.832	5.589	-0.1	0.511	NS
BRCA	Breast invasive carcinoma	112	1100	5.983	6.064	0.133	0.0361	NS
CESC	Cervical and endocervical cancers	3	306	5.405	5.565	NA	NA	NA
COAD	Colon adenocarcinoma	41	459	5.103	5.41	0.305	0.00157	NS
ESCA	Esophageal carcinoma	11	185	5.524	5.715	0.266	0.134	NS
GBM	Glioblastoma multiforme	5	166	6.791	5.895	NA	NA	NA
HNSC	Head and Neck squamous cell carcinoma	44	522	5.154	5.17	-0.017	0.871	NS
KIRC	Kidney renal clear cell carcinoma	72	534	6.02	5.555	-0.462	3.75e-14	NS
KIRP	Kidney renal papillary cell carcinoma	32	291	5.738	5.661	-0.119	0.262	NS
LAML	Acute Myeloid Leukemia	0	173	NA	6.795	NA	NA	NA
LGG	Brain Lower Grade Glioma	0	530	NA	6.331	NA	NA	NA
LIHC	Liver hepatocellular carcinoma	50	373	2.967	3.417	0.546	9.16e-07	NS
LUAD	Lung adenocarcinoma	59	517	5.341	5.6	0.335	3.49e-05	NS
LUSC	Lung squamous cell carcinoma	51	501	5.376	5.674	0.324	5.41e-05	NS
OV	Ovarian serous cystadenocarcinoma	0	307	NA	5.727	NA	NA	NA
PAAD	Pancreatic adenocarcinoma	4	179	5.555	5.564	NA	NA	NA
PCPG	Pheochromocytoma and Paraganglioma	3	184	5.021	6.63	NA	NA	NA
PRAD	Prostate adenocarcinoma	52	498	5.834	5.735	-0.101	0.192	NS
READ	Rectum adenocarcinoma	10	167	5.313	5.382	0.158	0.446	NS
SARC	Sarcoma	2	263	5.159	5.655	NA	NA	NA
SKCM	Skin Cutaneous Melanoma	1	472	5.185	5.931	NA	NA	NA
STAD	Stomach adenocarcinoma	35	415	4.996	5.493	0.423	1.69e-05	NS
TGCT	Testicular Germ Cell Tumors	0	156	NA	6.038	NA	NA	NA
THCA	Thyroid carcinoma	59	509	6.066	6.113	0.043	0.518	NS
THYM	Thymoma	2	120	5.7	5.572	NA	NA	NA
UCEC	Uterine Corpus Endometrial Carcinoma	35	546	5.756	5.959	0.16	0.104	NS

> Cancer Cell Line Encyclopedia (CCLE)

[ TOP ]

Tissue	Cell Line	Expression Level (Microarray)
Autonomic ganglia	CHP126	6.5
Autonomic ganglia	CHP212	7.4
Autonomic ganglia	IMR32	7.6
Autonomic ganglia	KELLY	7.2
Autonomic ganglia	KPNRTBM1	7
Autonomic ganglia	KPNSI9S	7
Autonomic ganglia	KPNYN	6.8
Autonomic ganglia	MHHNB11	8
Autonomic ganglia	NB1	6.9
Autonomic ganglia	NH6	7
Autonomic ganglia	SHSY5Y	7.3
Autonomic ganglia	SIMA	6.5
Autonomic ganglia	SKNAS	7.6
Autonomic ganglia	SKNBE2	7.5
Autonomic ganglia	SKNDZ	7.5
Autonomic ganglia	SKNFI	7.9
Autonomic ganglia	SKNSH	7
Biliary tract	HUCCT1	6.5
Biliary tract	HUH28	6.8
Biliary tract	SNU1079	6.4
Biliary tract	SNU1196	5.7
Biliary tract	SNU245	6.4
Biliary tract	SNU308	7
Biliary tract	SNU478	6.4
Bone	143B	7
Bone	A673	7.1
Bone	CADOES1	6.4
Bone	CAL78	6.7
Bone	G292CLONEA141B1	7.1
Bone	HOS	7.3
Bone	HS706T	7.5
Bone	HS737T	7.3
Bone	HS819T	7.1
Bone	HS821T	6.5
Bone	HS822T	7
Bone	HS863T	6.3
Bone	HS870T	6.8
Bone	HS888T	7
Bone	MG63	7.5
Bone	MHHES1	6.5
Bone	OUMS27	7.3
Bone	RDES	7.4
Bone	SJSA1	6.9
Bone	SKES1	7.4
Bone	SKNMC	7.7
Bone	SW1353	7.1
Bone	T173	7.5
Bone	TC71	7.3
Bone	U2OS	7.4
Breast	AU565	7
Breast	BT20	7.5
Breast	BT474	6.5
Breast	BT483	7
Breast	BT549	6.7
Breast	CAL120	6.1
Breast	CAL148	6.3
Breast	CAL51	7.2
Breast	CAL851	5.8
Breast	CAMA1	7.9
Breast	DU4475	7.4
Breast	EFM192A	7.1
Breast	EFM19	7.3
Breast	EVSAT	6.3
Breast	HCC1143	7.3
Breast	HCC1187	6.7
Breast	HCC1395	7.1
Breast	HCC1419	6.3
Breast	HCC1428	6
Breast	HCC1500	6.1
Breast	HCC1569	7.7
Breast	HCC1599	6.1
Breast	HCC1806	7
Breast	HCC1937	6.5
Breast	HCC1954	6.6
Breast	HCC202	6.7
Breast	HCC2157	6.4
Breast	HCC2218	6.4
Breast	HCC38	7.3
Breast	HCC70	7.1
Breast	HDQP1	6.3
Breast	HMC18	6.3
Breast	HS274T	6.4
Breast	HS281T	6.7
Breast	HS343T	6.5
Breast	HS578T	7.1
Breast	HS606T	7.5
Breast	HS739T	7.5
Breast	HS742T	6.9
Breast	JIMT1	5.9
Breast	KPL1	6.6
Breast	MCF7	6.5
Breast	MDAMB134VI	6.8
Breast	MDAMB157	6.9
Breast	MDAMB175VII	6.8
Breast	MDAMB231	6.2
Breast	MDAMB361	6.5
Breast	MDAMB415	6.7
Breast	MDAMB436	7.9
Breast	MDAMB453	7.8
Breast	MDAMB468	5.7
Breast	SKBR3	6.5
Breast	T47D	7.7
Breast	UACC812	6.1
Breast	UACC893	6.7
Breast	YMB1	7.3
Breast	ZR751	6.8
Breast	ZR7530	6.6
Central nervous system	1321N1	7.4
Central nervous system	42MGBA	7.8
Central nervous system	8MGBA	6.9
Central nervous system	A172	7
Central nervous system	AM38	6.3
Central nervous system	BECKER	7.4
Central nervous system	CAS1	6.9
Central nervous system	CCFSTTG1	6.8
Central nervous system	D283MED	7
Central nervous system	D341MED	7
Central nervous system	DAOY	6.6
Central nervous system	DBTRG05MG	6.8
Central nervous system	DKMG	6.8
Central nervous system	GAMG	7.5
Central nervous system	GB1	6.4
Central nervous system	GI1	8.4
Central nervous system	GMS10	7.6
Central nervous system	GOS3	7.6
Central nervous system	H4	7.5
Central nervous system	HS683	6.8
Central nervous system	KALS1	7
Central nervous system	KG1C	7.1
Central nervous system	KNS42	7.8
Central nervous system	KNS60	7.1
Central nervous system	KNS81	6.9
Central nervous system	KS1	7.2
Central nervous system	LN18	7.6
Central nervous system	LN229	6.9
Central nervous system	M059K	7.1
Central nervous system	MOGGCCM	7.2
Central nervous system	MOGGUVW	7.2
Central nervous system	NMCG1	6.4
Central nervous system	ONS76	7
Central nervous system	SF126	7.3
Central nervous system	SF295	6.8
Central nervous system	SNB19	7.1
Central nervous system	SNU1105	6.7
Central nervous system	SNU201	6.8
Central nervous system	SNU466	6.4
Central nervous system	SNU489	6.4
Central nervous system	SNU626	6.6
Central nervous system	SNU738	6.8
Central nervous system	SW1088	6.7
Central nervous system	SW1783	7.1
Central nervous system	T98G	7.6
Central nervous system	TM31	6.1
Central nervous system	U118MG	7
Central nervous system	U138MG	7.4
Central nervous system	U251MG	7.4
Central nervous system	U87MG	6.8
Central nervous system	YH13	7.6
Central nervous system	YKG1	7.4
Endometrium	AN3CA	7.7
Endometrium	COLO684	6.2
Endometrium	EFE184	6
Endometrium	EN	7.6
Endometrium	ESS1	7.3
Endometrium	HEC108	6.9
Endometrium	HEC151	7.1
Endometrium	HEC1A	7.1
Endometrium	HEC1B	7.2
Endometrium	HEC251	6.7
Endometrium	HEC265	6.8
Endometrium	HEC50B	6.6
Endometrium	HEC59	6
Endometrium	HEC6	7.3
Endometrium	ISHIKAWAHERAKLIO02ER	6.7
Endometrium	JHUEM1	7.1
Endometrium	JHUEM2	7.2
Endometrium	JHUEM3	6.5
Endometrium	KLE	6.4
Endometrium	MFE280	7.3
Endometrium	MFE296	7.8
Endometrium	MFE319	7.1
Endometrium	RL952	7.3
Endometrium	SNGM	7.1
Endometrium	SNU1077	6.5
Endometrium	SNU685	6.2
Endometrium	TEN	7.5
Haematopoietic and lymphoid	697	6.5
Haematopoietic and lymphoid	A3KAW	6.3
Haematopoietic and lymphoid	A4FUK	6.6
Haematopoietic and lymphoid	ALLSIL	6.5
Haematopoietic and lymphoid	AML193	6.9
Haematopoietic and lymphoid	AMO1	6.4
Haematopoietic and lymphoid	BCP1	6.9
Haematopoietic and lymphoid	BDCM	6.9
Haematopoietic and lymphoid	BL41	6.8
Haematopoietic and lymphoid	BL70	7.4
Haematopoietic and lymphoid	BV173	6.6
Haematopoietic and lymphoid	CA46	7.5
Haematopoietic and lymphoid	CI1	7.6
Haematopoietic and lymphoid	CMK115	6.3
Haematopoietic and lymphoid	CMK86	6.1
Haematopoietic and lymphoid	CMK	6.1
Haematopoietic and lymphoid	CMLT1	6.3
Haematopoietic and lymphoid	COLO775	5.9
Haematopoietic and lymphoid	DAUDI	6.8
Haematopoietic and lymphoid	DB	6.8
Haematopoietic and lymphoid	DEL	6.9
Haematopoietic and lymphoid	DND41	6.5
Haematopoietic and lymphoid	DOHH2	6.3
Haematopoietic and lymphoid	EB1	7.1
Haematopoietic and lymphoid	EB2	6.8
Haematopoietic and lymphoid	EHEB	6.5
Haematopoietic and lymphoid	EJM	6.2
Haematopoietic and lymphoid	EM2	6.7
Haematopoietic and lymphoid	EOL1	5.6
Haematopoietic and lymphoid	F36P	6
Haematopoietic and lymphoid	GA10	7
Haematopoietic and lymphoid	GDM1	6.9
Haematopoietic and lymphoid	GRANTA519	6.2
Haematopoietic and lymphoid	HDLM2	6.8
Haematopoietic and lymphoid	HDMYZ	6.8
Haematopoietic and lymphoid	HEL9217	6.7
Haematopoietic and lymphoid	HEL	6.2
Haematopoietic and lymphoid	HH	6.4
Haematopoietic and lymphoid	HL60	6.5
Haematopoietic and lymphoid	HPBALL	6.1
Haematopoietic and lymphoid	HS604T	6.6
Haematopoietic and lymphoid	HS611T	7.2
Haematopoietic and lymphoid	HS616T	6.9
Haematopoietic and lymphoid	HS751T	6.3
Haematopoietic and lymphoid	HT	8.1
Haematopoietic and lymphoid	HTK	6.1
Haematopoietic and lymphoid	HUNS1	7.4
Haematopoietic and lymphoid	HUT102	7.1
Haematopoietic and lymphoid	HUT78	7.2
Haematopoietic and lymphoid	JEKO1	6.5
Haematopoietic and lymphoid	JK1	6
Haematopoietic and lymphoid	JM1	6.8
Haematopoietic and lymphoid	JURKAT	6.4
Haematopoietic and lymphoid	JURLMK1	6.4
Haematopoietic and lymphoid	JVM2	6.5
Haematopoietic and lymphoid	JVM3	6.5
Haematopoietic and lymphoid	K562	6.8
Haematopoietic and lymphoid	KARPAS299	7.2
Haematopoietic and lymphoid	KARPAS422	7.5
Haematopoietic and lymphoid	KARPAS620	6.1
Haematopoietic and lymphoid	KASUMI1	5.7
Haematopoietic and lymphoid	KASUMI2	6.7
Haematopoietic and lymphoid	KASUMI6	6.8
Haematopoietic and lymphoid	KCL22	6.7
Haematopoietic and lymphoid	KE37	5.7
Haematopoietic and lymphoid	KE97	6.9
Haematopoietic and lymphoid	KG1	7.3
Haematopoietic and lymphoid	KHM1B	6.5
Haematopoietic and lymphoid	KIJK	7
Haematopoietic and lymphoid	KMH2	6.9
Haematopoietic and lymphoid	KMM1	6.9
Haematopoietic and lymphoid	KMS11	7.2
Haematopoietic and lymphoid	KMS12BM	6.8
Haematopoietic and lymphoid	KMS18	6.4
Haematopoietic and lymphoid	KMS20	7.2
Haematopoietic and lymphoid	KMS21BM	6.3
Haematopoietic and lymphoid	KMS26	6.3
Haematopoietic and lymphoid	KMS27	6.8
Haematopoietic and lymphoid	KMS28BM	6.4
Haematopoietic and lymphoid	KMS34	6.6
Haematopoietic and lymphoid	KO52	7
Haematopoietic and lymphoid	KOPN8	6.3
Haematopoietic and lymphoid	KU812	6.4
Haematopoietic and lymphoid	KYO1	6.8
Haematopoietic and lymphoid	L1236	7.6
Haematopoietic and lymphoid	L363	6.6
Haematopoietic and lymphoid	L428	6.8
Haematopoietic and lymphoid	L540	6.2
Haematopoietic and lymphoid	LAMA84	6.7
Haematopoietic and lymphoid	LOUCY	7.8
Haematopoietic and lymphoid	LP1	6
Haematopoietic and lymphoid	M07E	6.6
Haematopoietic and lymphoid	MC116	7.1
Haematopoietic and lymphoid	ME1	6.4
Haematopoietic and lymphoid	MEC1	6.5
Haematopoietic and lymphoid	MEC2	6.5
Haematopoietic and lymphoid	MEG01	7
Haematopoietic and lymphoid	MHHCALL2	7.1
Haematopoietic and lymphoid	MHHCALL3	7.2
Haematopoietic and lymphoid	MHHCALL4	6.9
Haematopoietic and lymphoid	MINO	7
Haematopoietic and lymphoid	MJ	7.5
Haematopoietic and lymphoid	MM1S	5.7
Haematopoietic and lymphoid	MOLM13	5.9
Haematopoietic and lymphoid	MOLM16	6.5
Haematopoietic and lymphoid	MOLM6	6.3
Haematopoietic and lymphoid	MOLP2	6.2
Haematopoietic and lymphoid	MOLP8	6.2
Haematopoietic and lymphoid	MOLT13	7.1
Haematopoietic and lymphoid	MOLT16	6.4
Haematopoietic and lymphoid	MOLT4	7.7
Haematopoietic and lymphoid	MONOMAC1	6.3
Haematopoietic and lymphoid	MONOMAC6	6.4
Haematopoietic and lymphoid	MOTN1	6.2
Haematopoietic and lymphoid	MUTZ5	6.9
Haematopoietic and lymphoid	MV411	6
Haematopoietic and lymphoid	NALM19	6.9
Haematopoietic and lymphoid	NALM1	6
Haematopoietic and lymphoid	NALM6	5.9
Haematopoietic and lymphoid	NAMALWA	6.3
Haematopoietic and lymphoid	NB4	6.5
Haematopoietic and lymphoid	NCIH929	6.1
Haematopoietic and lymphoid	NCO2	6.8
Haematopoietic and lymphoid	NOMO1	6
Haematopoietic and lymphoid	NUDHL1	6.4
Haematopoietic and lymphoid	NUDUL1	7
Haematopoietic and lymphoid	OCIAML2	6.1
Haematopoietic and lymphoid	OCIAML3	6.1
Haematopoietic and lymphoid	OCIAML5	5.7
Haematopoietic and lymphoid	OCILY10	7.7
Haematopoietic and lymphoid	OCILY19	6.6
Haematopoietic and lymphoid	OCILY3	7.2
Haematopoietic and lymphoid	OCIM1	6.2
Haematopoietic and lymphoid	OPM2	6.4
Haematopoietic and lymphoid	P12ICHIKAWA	6.4
Haematopoietic and lymphoid	P31FUJ	6.5
Haematopoietic and lymphoid	P3HR1	7.8
Haematopoietic and lymphoid	PCM6	6.6
Haematopoietic and lymphoid	PEER	7.8
Haematopoietic and lymphoid	PF382	6.9
Haematopoietic and lymphoid	PFEIFFER	7.1
Haematopoietic and lymphoid	PL21	5.4
Haematopoietic and lymphoid	RAJI	7.4
Haematopoietic and lymphoid	RCHACV	6.1
Haematopoietic and lymphoid	REC1	6.3
Haematopoietic and lymphoid	REH	7.6
Haematopoietic and lymphoid	RI1	6.9
Haematopoietic and lymphoid	RL	7.6
Haematopoietic and lymphoid	RPMI8226	6.4
Haematopoietic and lymphoid	RPMI8402	6.3
Haematopoietic and lymphoid	RS411	6.9
Haematopoietic and lymphoid	SEM	6.9
Haematopoietic and lymphoid	SET2	6.6
Haematopoietic and lymphoid	SIGM5	6.2
Haematopoietic and lymphoid	SKM1	5.9
Haematopoietic and lymphoid	SKMM2	6.4
Haematopoietic and lymphoid	SR786	6.8
Haematopoietic and lymphoid	ST486	6.8
Haematopoietic and lymphoid	SUDHL10	6.3
Haematopoietic and lymphoid	SUDHL1	6.5
Haematopoietic and lymphoid	SUDHL4	6.4
Haematopoietic and lymphoid	SUDHL5	6.4
Haematopoietic and lymphoid	SUDHL6	6.7
Haematopoietic and lymphoid	SUDHL8	6.3
Haematopoietic and lymphoid	SUPB15	7
Haematopoietic and lymphoid	SUPHD1	6.5
Haematopoietic and lymphoid	SUPM2	6.5
Haematopoietic and lymphoid	SUPT11	7
Haematopoietic and lymphoid	SUPT1	7.7
Haematopoietic and lymphoid	TALL1	6.7
Haematopoietic and lymphoid	TF1	6.3
Haematopoietic and lymphoid	THP1	6.7
Haematopoietic and lymphoid	TO175T	7.1
Haematopoietic and lymphoid	TOLEDO	7.4
Haematopoietic and lymphoid	U266B1	6.6
Haematopoietic and lymphoid	U937	6.8
Haematopoietic and lymphoid	UT7	6.4
Haematopoietic and lymphoid	WSUDLCL2	6.1
Kidney	769P	6.7
Kidney	786O	6.2
Kidney	A498	7.2
Kidney	A704	6.3
Kidney	ACHN	6.9
Kidney	BFTC909	6.7
Kidney	CAKI1	7.1
Kidney	CAKI2	6.7
Kidney	CAL54	6.7
Kidney	KMRC1	6
Kidney	KMRC20	7.1
Kidney	KMRC2	6.2
Kidney	KMRC3	7.1
Kidney	OSRC2	6.7
Kidney	RCC10RGB	7
Kidney	SNU1272	5.8
Kidney	SNU349	5.8
Kidney	TUHR10TKB	6.4
Kidney	TUHR14TKB	7.4
Kidney	TUHR4TKB	6.5
Kidney	VMRCRCW	7
Kidney	VMRCRCZ	7.2
Large intestine	C2BBE1	6.1
Large intestine	CCK81	6.3
Large intestine	CL11	6.6
Large intestine	CL14	6.1
Large intestine	CL34	6.2
Large intestine	CL40	6.5
Large intestine	COLO205	6.9
Large intestine	COLO320	6.1
Large intestine	COLO678	6.8
Large intestine	CW2	5.9
Large intestine	DLD1	6.7
Large intestine	GP2D	6.4
Large intestine	HCC56	8.5
Large intestine	HCT116	7
Large intestine	HCT15	6.8
Large intestine	HS675T	7.2
Large intestine	HS698T	6.3
Large intestine	HT115	6.1
Large intestine	HT29	7.1
Large intestine	HT55	6.3
Large intestine	KM12	6.5
Large intestine	LOVO	6.5
Large intestine	LS1034	7.1
Large intestine	LS123	5.9
Large intestine	LS180	6.6
Large intestine	LS411N	6.8
Large intestine	LS513	6.3
Large intestine	MDST8	5.9
Large intestine	NCIH508	7.3
Large intestine	NCIH716	7
Large intestine	NCIH747	6.5
Large intestine	OUMS23	7.4
Large intestine	RCM1	6.8
Large intestine	RKO	7.1
Large intestine	SKCO1	6.6
Large intestine	SNU1040	6.2
Large intestine	SNU1197	6.3
Large intestine	SNU175	6
Large intestine	SNU283	6.3
Large intestine	SNU407	7.2
Large intestine	SNU503	6.6
Large intestine	SNU61	6.4
Large intestine	SNU81	6.2
Large intestine	SNUC1	6.3
Large intestine	SNUC2A	7.6
Large intestine	SNUC4	6.3
Large intestine	SNUC5	6.8
Large intestine	SW1116	6.5
Large intestine	SW1417	6.3
Large intestine	SW1463	5.8
Large intestine	SW403	6
Large intestine	SW480	6
Large intestine	SW48	6.3
Large intestine	SW620	7.2
Large intestine	SW837	6.5
Large intestine	SW948	6.2
Large intestine	T84	6.2
Liver	ALEXANDERCELLS	6.2
Liver	C3A	6
Liver	HEP3B217	6
Liver	HEPG2	5.7
Liver	HLE	6.5
Liver	HLF	6.6
Liver	HUH1	7.2
Liver	HUH6	5.4
Liver	HUH7	6.3
Liver	JHH1	6.8
Liver	JHH2	6.2
Liver	JHH4	7.2
Liver	JHH5	6.6
Liver	JHH6	6
Liver	JHH7	6.6
Liver	LI7	6.4
Liver	PLCPRF5	7.6
Liver	SKHEP1	6.3
Liver	SNU182	6.3
Liver	SNU387	6.2
Liver	SNU398	6.8
Liver	SNU423	6.4
Liver	SNU449	7
Liver	SNU475	7.4
Liver	SNU761	7.4
Liver	SNU878	6.5
Liver	SNU886	6.6
Lung	A549	6.6
Lung	ABC1	6.8
Lung	BEN	6.9
Lung	CAL12T	7
Lung	CALU1	6.5
Lung	CALU3	6.2
Lung	CALU6	8.1
Lung	CHAGOK1	6.4
Lung	COLO668	6.5
Lung	COLO699	6.5
Lung	CORL105	6.7
Lung	CORL23	7.1
Lung	CORL24	6
Lung	CORL279	5.7
Lung	CORL311	5.9
Lung	CORL47	6.3
Lung	CORL51	6.3
Lung	CORL88	6.3
Lung	CORL95	6
Lung	CPCN	8.3
Lung	DMS114	8.1
Lung	DMS153	6.7
Lung	DMS273	5.9
Lung	DMS454	6
Lung	DMS53	7.2
Lung	DMS79	7
Lung	DV90	6.3
Lung	EBC1	6.6
Lung	EPLC272H	7
Lung	HARA	7.3
Lung	HCC1171	6.3
Lung	HCC1195	6.4
Lung	HCC15	6.8
Lung	HCC2279	6.2
Lung	HCC2935	6.7
Lung	HCC33	6.7
Lung	HCC366	5.8
Lung	HCC4006	6.1
Lung	HCC44	6.5
Lung	HCC78	6.7
Lung	HCC827	6.6
Lung	HCC95	6.3
Lung	HLC1	6.6
Lung	HLFA	6.9
Lung	HS229T	6.9
Lung	HS618T	7
Lung	IALM	7.3
Lung	KNS62	7
Lung	LC1F	6.8
Lung	LC1SQSF	6.5
Lung	LCLC103H	6.7
Lung	LCLC97TM1	6.4
Lung	LK2	7
Lung	LOUNH91	6.9
Lung	LU65	6.6
Lung	LU99	7.6
Lung	LUDLU1	7.1
Lung	LXF289	6.1
Lung	MORCPR	6.2
Lung	NCIH1048	7.5
Lung	NCIH1092	6.2
Lung	NCIH1105	6.8
Lung	NCIH1155	7.3
Lung	NCIH1184	7.4
Lung	NCIH1299	6.8
Lung	NCIH1339	6.6
Lung	NCIH1341	7.1
Lung	NCIH1355	6.9
Lung	NCIH1373	7.6
Lung	NCIH1385	7.5
Lung	NCIH1395	6.3
Lung	NCIH1435	6.3
Lung	NCIH1436	6.4
Lung	NCIH1437	6.6
Lung	NCIH146	6.8
Lung	NCIH1563	6.6
Lung	NCIH1568	6.6
Lung	NCIH1573	8
Lung	NCIH1581	6.6
Lung	NCIH1618	6.9
Lung	NCIH1623	7
Lung	NCIH1648	7.2
Lung	NCIH1650	7.2
Lung	NCIH1651	7.5
Lung	NCIH1666	6.7
Lung	NCIH1693	6.7
Lung	NCIH1694	7.1
Lung	NCIH1703	7.7
Lung	NCIH1734	6.7
Lung	NCIH1755	7.1
Lung	NCIH1781	6.9
Lung	NCIH1792	7.2
Lung	NCIH1793	7
Lung	NCIH1836	7.1
Lung	NCIH1838	7
Lung	NCIH1869	5.9
Lung	NCIH1876	7.1
Lung	NCIH1915	6.6
Lung	NCIH1930	7.5
Lung	NCIH1944	6.2
Lung	NCIH1963	7.9
Lung	NCIH196	7.7
Lung	NCIH1975	7
Lung	NCIH2009	6.3
Lung	NCIH2023	6.9
Lung	NCIH2029	7.2
Lung	NCIH2030	8.2
Lung	NCIH2066	7.4
Lung	NCIH2081	6.6
Lung	NCIH2085	7.2
Lung	NCIH2087	7.7
Lung	NCIH209	7.4
Lung	NCIH2106	6.3
Lung	NCIH2110	5.9
Lung	NCIH211	6.7
Lung	NCIH2122	6.7
Lung	NCIH2126	6.5
Lung	NCIH2141	7
Lung	NCIH2170	5.9
Lung	NCIH2171	7.4
Lung	NCIH2172	6.4
Lung	NCIH2196	6.6
Lung	NCIH2227	7.3
Lung	NCIH2228	6.9
Lung	NCIH226	6.2
Lung	NCIH2286	6.8
Lung	NCIH2291	6.3
Lung	NCIH2342	6.5
Lung	NCIH2347	5.9
Lung	NCIH23	7.2
Lung	NCIH2405	7.4
Lung	NCIH2444	6.2
Lung	NCIH292	6.2
Lung	NCIH322	6.9
Lung	NCIH3255	6.2
Lung	NCIH358	7.7
Lung	NCIH441	7
Lung	NCIH446	6.4
Lung	NCIH460	6.9
Lung	NCIH510	7.7
Lung	NCIH520	7.5
Lung	NCIH522	7.2
Lung	NCIH524	6.9
Lung	NCIH526	7
Lung	NCIH596	6.5
Lung	NCIH647	6.6
Lung	NCIH650	6.9
Lung	NCIH661	7.3
Lung	NCIH69	7.3
Lung	NCIH727	5.9
Lung	NCIH810	8.3
Lung	NCIH82	7.6
Lung	NCIH838	7.2
Lung	NCIH841	7
Lung	NCIH854	5.5
Lung	NCIH889	8.1
Lung	PC14	7.2
Lung	RERFLCAD1	7.1
Lung	RERFLCAD2	6.5
Lung	RERFLCAI	6.7
Lung	RERFLCKJ	7.6
Lung	RERFLCMS	6.8
Lung	RERFLCSQ1	7.6
Lung	SBC5	7.7
Lung	SCLC21H	7.3
Lung	SHP77	7.1
Lung	SKLU1	7
Lung	SKMES1	7.8
Lung	SQ1	6.3
Lung	SW1271	6.8
Lung	SW1573	6.3
Lung	SW900	7.1
Lung	VMRCLCD	6.4
Lung	VMRCLCP	6.9
Oesophagus	COLO680N	6.5
Oesophagus	ECGI10	7
Oesophagus	KYSE140	6.9
Oesophagus	KYSE150	6.6
Oesophagus	KYSE180	6.9
Oesophagus	KYSE270	6.6
Oesophagus	KYSE30	6.4
Oesophagus	KYSE410	7.4
Oesophagus	KYSE450	7.3
Oesophagus	KYSE510	6.6
Oesophagus	KYSE520	7.2
Oesophagus	KYSE70	6.5
Oesophagus	OE19	6.1
Oesophagus	OE33	6.9
Oesophagus	TE10	7
Oesophagus	TE11	6.7
Oesophagus	TE14	6.3
Oesophagus	TE15	7.4
Oesophagus	TE1	6.6
Oesophagus	TE4	6.8
Oesophagus	TE5	6.4
Oesophagus	TE6	7.2
Oesophagus	TE8	7.5
Oesophagus	TE9	7.2
Oesophagus	TT	7.3
Ovary	59M	5.7
Ovary	A2780	8.1
Ovary	CAOV3	7.1
Ovary	CAOV4	7.3
Ovary	COLO704	7.6
Ovary	COV318	6.9
Ovary	COV362	6
Ovary	COV434	6.3
Ovary	COV504	6.7
Ovary	COV644	5.9
Ovary	EFO21	6.6
Ovary	EFO27	7.9
Ovary	ES2	6.8
Ovary	FUOV1	7.1
Ovary	HEYA8	5.8
Ovary	HS571T	6.9
Ovary	IGROV1	7.2
Ovary	JHOC5	6.2
Ovary	JHOM1	7.3
Ovary	JHOM2B	5.6
Ovary	JHOS2	5.8
Ovary	JHOS4	7.4
Ovary	KURAMOCHI	6.5
Ovary	MCAS	6.8
Ovary	NIHOVCAR3	7.3
Ovary	OAW28	5.9
Ovary	OAW42	6.5
Ovary	OC314	6.7
Ovary	OC316	6.8
Ovary	ONCODG1	6.4
Ovary	OV56	7.5
Ovary	OV7	6
Ovary	OV90	6.8
Ovary	OVCAR4	6.2
Ovary	OVCAR8	6.2
Ovary	OVISE	6.5
Ovary	OVK18	6.6
Ovary	OVKATE	7.1
Ovary	OVMANA	6.2
Ovary	OVSAHO	7
Ovary	OVTOKO	5.4
Ovary	RMGI	6.2
Ovary	RMUGS	6.3
Ovary	SKOV3	7.6
Ovary	SNU119	6
Ovary	SNU840	7
Ovary	SNU8	6.3
Ovary	TOV112D	7.1
Ovary	TOV21G	7.4
Ovary	TYKNU	7.3
Pancreas	ASPC1	6.9
Pancreas	BXPC3	6.3
Pancreas	CAPAN1	7.3
Pancreas	CAPAN2	6.7
Pancreas	CFPAC1	7.4
Pancreas	DANG	6.6
Pancreas	HPAC	6.9
Pancreas	HPAFII	6.3
Pancreas	HS766T	7
Pancreas	HUPT3	6.6
Pancreas	HUPT4	6.2
Pancreas	KCIMOH1	7
Pancreas	KLM1	6.5
Pancreas	KP2	7.3
Pancreas	KP3	6.7
Pancreas	KP4	7.2
Pancreas	L33	7.2
Pancreas	MIAPACA2	7.2
Pancreas	PANC0203	6.9
Pancreas	PANC0213	7.3
Pancreas	PANC0327	6.4
Pancreas	PANC0403	7.1
Pancreas	PANC0504	6.9
Pancreas	PANC0813	7
Pancreas	PANC1005	7.3
Pancreas	PANC1	7.7
Pancreas	PATU8902	6.7
Pancreas	PATU8988S	6.2
Pancreas	PATU8988T	6.1
Pancreas	PK1	8
Pancreas	PK45H	6.6
Pancreas	PK59	6.4
Pancreas	PL45	6.8
Pancreas	PSN1	7.2
Pancreas	QGP1	7.9
Pancreas	SNU213	6
Pancreas	SNU324	6.6
Pancreas	SNU410	6.1
Pancreas	SU8686	6.6
Pancreas	SUIT2	6.1
Pancreas	SW1990	6.3
Pancreas	T3M4	6.7
Pancreas	TCCPAN2	6.1
Pancreas	YAPC	6.6
Pleura	ACCMESO1	6.6
Pleura	DM3	6.2
Pleura	ISTMES1	6.2
Pleura	ISTMES2	7.5
Pleura	JL1	6.5
Pleura	MPP89	6.8
Pleura	MSTO211H	7.1
Pleura	NCIH2052	6.1
Pleura	NCIH2452	7.7
Pleura	NCIH28	7.7
Prostate	22RV1	6.8
Prostate	DU145	6.6
Prostate	LNCAPCLONEFGC	6.7
Prostate	MDAPCA2B	6.8
Prostate	NCIH660	6.2
Prostate	PC3	6.7
Prostate	VCAP	6.8
Salivary gland	A253	5.9
Salivary gland	YD15	6.6
Skin	A101D	6.7
Skin	A2058	6.2
Skin	A375	6.8
Skin	C32	7.1
Skin	CHL1	6.7
Skin	CJM	6.7
Skin	COLO679	5.7
Skin	COLO741	7.4
Skin	COLO783	6.4
Skin	COLO792	5.9
Skin	COLO800	7.2
Skin	COLO818	6.6
Skin	COLO829	6.4
Skin	COLO849	6.1
Skin	G361	7.7
Skin	GRM	6.2
Skin	HMCB	6.7
Skin	HS294T	6
Skin	HS600T	7.1
Skin	HS688AT	6.9
Skin	HS695T	7
Skin	HS839T	6.7
Skin	HS852T	6.4
Skin	HS895T	6.4
Skin	HS934T	6.9
Skin	HS936T	7
Skin	HS939T	6
Skin	HS940T	6.8
Skin	HS944T	6.2
Skin	HT144	6.8
Skin	IGR1	6.8
Skin	IGR37	6.5
Skin	IGR39	6.5
Skin	IPC298	6.2
Skin	K029AX	6.8
Skin	LOXIMVI	6.6
Skin	MALME3M	7.1
Skin	MDAMB435S	6.3
Skin	MELHO	6.9
Skin	MELJUSO	6.7
Skin	MEWO	6.7
Skin	RPMI7951	6.6
Skin	RVH421	6.8
Skin	SH4	6.5
Skin	SKMEL1	7.3
Skin	SKMEL24	6.3
Skin	SKMEL28	6.7
Skin	SKMEL2	6.8
Skin	SKMEL30	6.4
Skin	SKMEL31	6.3
Skin	SKMEL3	7
Skin	SKMEL5	6.4
Skin	UACC257	6.4
Skin	UACC62	6.6
Skin	WM115	6.7
Skin	WM1799	6.3
Skin	WM2664	6.3
Skin	WM793	6.3
Skin	WM88	6.4
Skin	WM983B	6.5
Small intestine	HUTU80	7.2
Soft tissue	A204	7.5
Soft tissue	G401	7.6
Soft tissue	G402	7.5
Soft tissue	GCT	7.4
Soft tissue	HS729	7.1
Soft tissue	HT1080	6.7
Soft tissue	KYM1	7.2
Soft tissue	MESSA	8.1
Soft tissue	RD	7
Soft tissue	RH30	5.6
Soft tissue	RH41	7
Soft tissue	RKN	7.9
Soft tissue	S117	6.3
Soft tissue	SJRH30	7.1
Soft tissue	SKLMS1	7.5
Soft tissue	SKUT1	7.2
Soft tissue	TE125T	6.2
Soft tissue	TE159T	6.5
Soft tissue	TE441T	6.3
Soft tissue	TE617T	8.1
Stomach	2313287	6.3
Stomach	AGS	7.5
Stomach	AZ521	6.6
Stomach	ECC10	7.5
Stomach	ECC12	6.5
Stomach	FU97	6.2
Stomach	GCIY	6.7
Stomach	GSS	6.4
Stomach	GSU	6.1
Stomach	HGC27	7
Stomach	HS746T	7.4
Stomach	HUG1N	6.5
Stomach	IM95	5.4
Stomach	KATOIII	6.3
Stomach	KE39	6.5
Stomach	LMSU	6.9
Stomach	MKN1	6.3
Stomach	MKN45	6.1
Stomach	MKN74	7.7
Stomach	MKN7	5.8
Stomach	NCCSTCK140	6.6
Stomach	NCIN87	7
Stomach	NUGC2	6.6
Stomach	NUGC3	6.3
Stomach	NUGC4	6.1
Stomach	OCUM1	6.7
Stomach	RERFGC1B	7.7
Stomach	SH10TC	7.1
Stomach	SNU16	6.2
Stomach	SNU1	7
Stomach	SNU216	6.7
Stomach	SNU520	6.5
Stomach	SNU5	6.1
Stomach	SNU601	6
Stomach	SNU620	5.9
Stomach	SNU668	6
Stomach	SNU719	6
Stomach	TGBC11TKB	6.5
Thyroid	8305C	6.4
Thyroid	8505C	6.6
Thyroid	BCPAP	7.1
Thyroid	BHT101	6.2
Thyroid	CAL62	6.9
Thyroid	CGTHW1	6.6
Thyroid	FTC133	6.3
Thyroid	FTC238	6.1
Thyroid	ML1	7.8
Thyroid	SW579	7
Thyroid	TT2609C02	6.5
Thyroid	TT	7.3
Upper aerodigestive tract	BHY	6.9
Upper aerodigestive tract	BICR16	6.1
Upper aerodigestive tract	BICR18	6.3
Upper aerodigestive tract	BICR22	5.8
Upper aerodigestive tract	BICR31	6
Upper aerodigestive tract	BICR56	6.2
Upper aerodigestive tract	BICR6	5.6
Upper aerodigestive tract	CAL27	6.6
Upper aerodigestive tract	CAL33	6.3
Upper aerodigestive tract	DETROIT562	6.6
Upper aerodigestive tract	FADU	7.7
Upper aerodigestive tract	HS840T	7.1
Upper aerodigestive tract	HSC2	6.4
Upper aerodigestive tract	HSC3	6.4
Upper aerodigestive tract	HSC4	7.1
Upper aerodigestive tract	PECAPJ15	6.7
Upper aerodigestive tract	PECAPJ34CLONEC12	6
Upper aerodigestive tract	PECAPJ41CLONED2	5.8
Upper aerodigestive tract	PECAPJ49	6.3
Upper aerodigestive tract	SCC15	6.4
Upper aerodigestive tract	SCC25	6.1
Upper aerodigestive tract	SCC4	6.2
Upper aerodigestive tract	SCC9	6.1
Upper aerodigestive tract	SNU1076	6.5
Upper aerodigestive tract	SNU1214	6.2
Upper aerodigestive tract	SNU46	6.8
Upper aerodigestive tract	SNU899	6
Upper aerodigestive tract	YD10B	7.3
Upper aerodigestive tract	YD38	6.2
Upper aerodigestive tract	YD8	7
Urinary tract	5637	6.9
Urinary tract	639V	6.7
Urinary tract	647V	6
Urinary tract	BC3C	6.5
Urinary tract	BFTC905	6.2
Urinary tract	CAL29	6.8
Urinary tract	HS172T	6.6
Urinary tract	HT1197	5.7
Urinary tract	HT1376	7.2
Urinary tract	J82	7.4
Urinary tract	JMSU1	7
Urinary tract	KMBC2	7.2
Urinary tract	KU1919	6.9
Urinary tract	RT11284	6.4
Urinary tract	RT112	6.6
Urinary tract	RT4	6.9
Urinary tract	SCABER	6.2
Urinary tract	SW1710	6.4
Urinary tract	SW780	7.8
Urinary tract	T24	7.6
Urinary tract	TCCSUP	5.7
Urinary tract	UMUC1	5.6
Urinary tract	UMUC3	7.2
Urinary tract	VMCUB1	7.1

> The Human Protein Atlas (HPA)

[ TOP ]

Tissue	Expression Level (TPM)
Adipose tissue	7.9
Adrenal gland	15.1
Appendix	14.1
Bone marrow	7.3
Breast	13.1
Cerebral cortex	29
Cervix, uterine	26.9
Colon	8.5
Duodenum	6.6
Endometrium	26.3
Epididymis	19.6
Esophagus	6.6
Fallopian tube	23.7
Gallbladder	17.1
Heart muscle	6.7
Kidney	10
Liver	2.1
Lung	12.2
Lymph node	10.3
Ovary	20.5
Pancreas	1.6
Parathyroid gland	49.6
Placenta	17.2
Prostate	18.8
Rectum	11.4
Salivary gland	4.3
Seminal vesicle	17.9
Skeletal muscle	2.5
Skin	10.9
Small intestine	4.4
Smooth muscle	24
Spleen	11.9
Stomach	7.3
Testis	39.6
Thyroid gland	29.6
Tonsil	11.8
Urinary bladder	14.4

> Text Mining based Expression

[ TOP ]

PMID	Expression	Cancer	Evidence
26261485	Underexpression	Colorectal Carcinoma	53BP1 intensity was found to be associated with tumor location (P < 0.05), and the low expression of 53BP1 revealed decreased survival time compared with high expression in subgroups as male, tumor size > 5 cm, tumor located at right side, T stage as T3-T4, N0, clinical stage as I-II (P < 0.05).
24681733	Overexpression	Cervical Carcinoma	We found that the level of 53BP1 NF increased in the following order: normal cervical tissues, cervical intraepithelial neoplasia (CIN) 1, CIN2/3, and cervical cancers, indicating that the level of 53BP1 NF increases as cervical cancer initiates and progresses.
24197907	Overexpression	Non-Small Cell Lung Cancer	Patients expressing low levels of both BRCA1 and 53BP1 obtained a median progression-free survival of 10.3 months and overall survival of 19.3 months, while among those with low BRCA1 and high 53BP1 progression-free survival was 5.9 months (P less than 0.0001) and overall survival was 8.2 months (P=0.001).
23246380	Overexpression	Breast Carcinoma	BRCA1-mutated ovarian carcinomas have higher 53BP1 protein expression than wildtype or BRCA2-mutated carcinomas, in opposition to previous findings in breast carcinomas.
22520477	Underexpression	Breast Carcinoma	Low expression of 53BP1 was associated with worse outcomes for all endpoints studied, including 10-year IBRFS (76.8% vs. 90.5%; P=.01), OS (66.4% vs. 81.7%; P=.02), CSS (66.0% vs. 87.4%; P<.01), DMFS (55.9% vs. 87.0%; P<.01), and RFS (45.2% vs. 80.6%; P<.01).
20098063	Overexpression	Gastric Carcinoma	In gastric carcinoma cells, 53BP1 and gamma-H2AX were highly expressed as compared to normal epithelial cells and gastric adenoma (p<0.01).
28475402	Underexpression	Breast Carcinoma	Tumors with worse prognosis (tumor grade 3 and triple negative) showed reduced expression of tBRCT genes, notably, PAXIP1 and TP53BP1.
28442502	Overexpression	Plasma Cell Myeloma	Immunoblot and qRT-PCR analysis confirmed that γ-H2A.X, ATM, ATR, Chk1, Chk2, RAD51, 53BP1, BRCA1, and BRCA2 were upregulated/activated.

Summary
Symbol	TP53BP1
Name	tumor protein p53 binding protein 1
Aliases	53BP1; p202; TDRD30; tumor protein p53-binding protein, 1; p53BP1; p53-binding protein 1; tumor protein 53-b ......
Location	15q15.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Somatic copy number alteration in primary tomur tissue

> The Cancer Genome Atlas (TCGA)

[ TOP ]

Correlation between expression and SCNA as well as percentage of patients in different status.

Cancer	Full Name	# Sample	R	P	% Loss	% Neutral	% Gain	Status
BLCA	Bladder urothelial carcinoma	404	0.449	2.08e-21	37.9	53.7	8.4	Loss
BRCA	Breast invasive carcinoma	1075	0.482	1.24e-63	35.8	57.6	6.6	Loss
CESC	Cervical and endocervical cancers	292	0.448	8.71e-16	22.9	62.7	14.4	Neutral
COAD	Colon adenocarcinoma	449	0.437	2.38e-22	37.6	59	3.3	Loss
ESCA	Esophageal carcinoma	183	0.408	1.03e-08	33.9	49.2	16.9	Loss
GBM	Glioblastoma multiforme	147	0.542	1.39e-12	27.9	66.7	5.4	Neutral
HNSC	Head and Neck squamous cell carcinoma	514	0.309	7.62e-13	23.5	62.3	14.2	Neutral
KIRC	Kidney renal clear cell carcinoma	525	0.258	2.03e-09	7.6	87.8	4.6	Neutral
KIRP	Kidney renal papillary cell carcinoma	288	0.11	0.0625	11.8	86.5	1.7	Neutral
LAML	Acute Myeloid Leukemia	166	0.084	0.284	2.4	97.6	0	Neutral
LGG	Brain Lower Grade Glioma	513	0.278	1.43e-10	12.1	86.5	1.4	Neutral
LIHC	Liver hepatocellular carcinoma	364	0.126	0.0159	19.8	70.9	9.3	Neutral
LUAD	Lung adenocarcinoma	512	0.391	3.77e-20	52	41.4	6.6	Loss
LUSC	Lung squamous cell carcinoma	498	0.491	1.28e-31	33.9	45	21.1	Loss
OV	Ovarian serous cystadenocarcinoma	300	0.646	9.37e-37	60.3	34.7	5	Loss
PAAD	Pancreatic adenocarcinoma	177	0.405	2.33e-08	18.6	75.1	6.2	Neutral
PCPG	Pheochromocytoma and Paraganglioma	162	0.236	0.00246	2.5	89.5	8	Neutral
PRAD	Prostate adenocarcinoma	491	0.442	7.56e-25	13	85.9	1	Neutral
READ	Rectum adenocarcinoma	164	0.497	1.26e-11	48.2	49.4	2.4	Loss
SARC	Sarcoma	255	0.429	7.75e-13	22.4	54.5	23.1	Neutral
SKCM	Skin Cutaneous Melanoma	367	0.605	4.6e-38	24.8	55	20.2	Neutral
STAD	Stomach adenocarcinoma	413	0.336	2.22e-12	26.4	66.8	6.8	Neutral
TGCT	Testicular Germ Cell Tumors	150	0.414	1.42e-07	22.7	42	35.3	Gain
THCA	Thyroid carcinoma	497	0.223	4.85e-07	1.8	98.2	0	Neutral
THYM	Thymoma	119	0.049	0.598	1.7	89.1	9.2	Neutral
UCEC	Uterine Corpus Endometrial Carcinoma	537	0.4	4.57e-22	25.5	72.1	2.4	Neutral

Summary
Symbol	TP53BP1
Name	tumor protein p53 binding protein 1
Aliases	53BP1; p202; TDRD30; tumor protein p53-binding protein, 1; p53BP1; p53-binding protein 1; tumor protein 53-b ......
Location	15q15.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Methylation level in the promoter region of CR

> Methylation level in the promoter region of CR

[ TOP ]

Correlation between expression and methylation as well as differential methylation analysis.

Cancer	Full Name	R	P	# N	# T	Delta beta (T vs N)	P value (T vs N)	Status
BLCA	Bladder urothelial carcinoma	-0.26	6.01e-08	17	408	-0.044	0.00875	NS/NA
BRCA	Breast invasive carcinoma	-0.247	1.89e-13	83	785	0.003	0.0131	NS/NA
CESC	Cervical and endocervical cancers	-0.239	2.33e-05	3	306	NA	NA	NS/NA
COAD	Colon adenocarcinoma	-0.196	0.00047	19	297	-0.003	0.578	NS/NA
ESCA	Esophageal carcinoma	-0.148	0.0396	9	185	NA	NA	NS/NA
GBM	Glioblastoma multiforme	-0.354	0.00403	1	64	NA	NA	NS/NA
HNSC	Head and Neck squamous cell carcinoma	-0.281	3.19e-11	20	522	-0.002	0.845	NS/NA
KIRC	Kidney renal clear cell carcinoma	-0.191	0.000377	24	319	0.049	9.89e-22	NS/NA
KIRP	Kidney renal papillary cell carcinoma	-0.275	1.52e-06	23	275	0.005	2.84e-06	NS/NA
LAML	Acute Myeloid Leukemia	-0.156	0.0426	0	170	NA	NA	NS/NA
LGG	Brain Lower Grade Glioma	-0.196	5.98e-06	0	530	NA	NA	NS/NA
LIHC	Liver hepatocellular carcinoma	-0.179	0.000248	41	373	0.006	0.0111	NS/NA
LUAD	Lung adenocarcinoma	-0.203	8.38e-06	21	456	-0.016	0.214	NS/NA
LUSC	Lung squamous cell carcinoma	-0.302	2.56e-09	8	370	NA	NA	NS/NA
OV	Ovarian serous cystadenocarcinoma	-0.633	0.076	0	9	NA	NA	NS/NA
PAAD	Pancreatic adenocarcinoma	-0.215	0.00352	4	179	NA	NA	NS/NA
PCPG	Pheochromocytoma and Paraganglioma	-0.44	4.17e-10	3	184	NA	NA	NS/NA
PRAD	Prostate adenocarcinoma	-0.292	7.16e-12	35	498	0.005	0.644	NS/NA
READ	Rectum adenocarcinoma	-0.338	0.000578	2	99	NA	NA	NS/NA
SARC	Sarcoma	-0.29	1.93e-06	0	263	NA	NA	NS/NA
SKCM	Skin Cutaneous Melanoma	-0.368	9.53e-17	1	471	NA	NA	NS/NA
STAD	Stomach adenocarcinoma	-0.293	9.51e-09	0	372	NA	NA	NS/NA
TGCT	Testicular Germ Cell Tumors	-0.504	1.36e-11	0	156	NA	NA	NS/NA
THCA	Thyroid carcinoma	-0.165	9.28e-05	50	509	-0.002	0.589	NS/NA
THYM	Thymoma	-0.212	0.0193	2	120	NA	NA	NS/NA
UCEC	Uterine Corpus Endometrial Carcinoma	-0.231	5.4e-07	34	431	-0.002	0.338	NS/NA

Summary
Symbol	TP53BP1
Name	tumor protein p53 binding protein 1
Aliases	53BP1; p202; TDRD30; tumor protein p53-binding protein, 1; p53BP1; p53-binding protein 1; tumor protein 53-b ......
Location	15q15.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Primary tumor tissue from TCGA > Normal tumor tissue from HPA

>The Cancer Genome Atlas (TCGA)

[ TOP ]

Cancer	Full Name	# Sample	Median (abundance)	MAD (abundance)
BLCA	Bladder urothelial carcinoma	344	0.021	0.337
BRCA	Breast invasive carcinoma	892	0.008	0.374
CESC	Cervical and endocervical cancers	173	-0.081	0.295
COAD	Colon adenocarcinoma	362	-0.013	0.364
ESCA	Esophageal carcinoma	126	-0.075	0.33
GBM	Glioblastoma multiforme	244	0	0.393
HNSC	Head and Neck squamous cell carcinoma	212	1.228	0.399
KIRC	Kidney renal clear cell carcinoma	478	0.016	0.207
KIRP	Kidney renal papillary cell carcinoma	216	0	0.384
LGG	Brain Lower Grade Glioma	435	-0.029	0.291
LIHC	Liver hepatocellular carcinoma	184	-0.031	0.094
LUAD	Lung adenocarcinoma	365	-0.025	0.259
LUSC	Lung squamous cell carcinoma	328	-0.02	0.331
OV	Ovarian serous cystadenocarcinoma	436	0.002	0.345
PAAD	Pancreatic adenocarcinoma	123	0.008	0.296
PCPG	Pheochromocytoma and Paraganglioma	82	-0.001	0.191
PRAD	Prostate adenocarcinoma	352	-0.019	0.351
READ	Rectum adenocarcinoma	131	0.05	0.406
SARC	Sarcoma	226	0.015	0.357
SKCM	Skin Cutaneous Melanoma	355	-0.026	0.353
STAD	Stomach adenocarcinoma	357	-0.012	0.42
TGCT	Testicular Germ Cell Tumors	122	-0.081	0.245
THCA	Thyroid carcinoma	224	1.956	0.38
THYM	Thymoma	90	-0.047	0.131
UCEC	Uterine Corpus Endometrial Carcinoma	440	-0.031	0.335

> The Human Protein Atlas (HPA)

[ TOP ]

Tissue	Level	Level Name
Adrenal gland	3	High
Appendix	2	Medium
Bone marrow	2	Medium
Breast	2	Medium
Bronchus	3	High
Caudate	3	High
Cerebellum	3	High
Cerebral cortex	3	High
Cervix, uterine	3	High
Colon	2	Medium
Duodenum	2	Medium
Endometrium	3	High
Epididymis	2	Medium
Esophagus	2	Medium
Fallopian tube	3	High
Gallbladder	3	High
Heart muscle	3	High
Hippocampus	3	High
Kidney	2	Medium
Liver	2	Medium
Lung	3	High
Lymph node	2	Medium
Nasopharynx	3	High
Oral mucosa	2	Medium
Ovary	2	Medium
Pancreas	2	Medium
Parathyroid gland	3	High
Placenta	3	High
Prostate	3	High
Rectum	2	Medium
Salivary gland	2	Medium
Seminal vesicle	2	Medium
Skeletal muscle	2	Medium
Skin	3	High
Small intestine	2	Medium
Smooth muscle	2	Medium
Soft tissue	2	Medium
Spleen	2	Medium
Stomach	2	Medium
Testis	3	High
Thyroid gland	3	High
Tonsil	2	Medium
Urinary bladder	2	Medium
Vagina	2	Medium

Summary
Symbol	TP53BP1
Name	tumor protein p53 binding protein 1
Aliases	53BP1; p202; TDRD30; tumor protein p53-binding protein, 1; p53BP1; p53-binding protein 1; tumor protein 53-b ......
Location	15q15.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Association between expresson and subtype > Overall survival analysis based on expression > Association between expresson and stage > Association between expresson and grade

> Subtype

[ TOP ]

Association between expresson and subtype.

Cancer	Full Name	# Patients	P Value (Kruskal-Wallis)	Association	Source
BLCA	Bladder urothelial carcinoma	128	0.979	NS	24476821
BRCA	Breast invasive carcinoma	521	2.5e-17	Significant	23000897
COAD	Colon adenocarcinoma	149	0.326	NS	22810696
GBM	Glioblastoma multiforme	157	0.000267	Significant	26824661
HNSC	Head and Neck squamous cell carcinoma	279	1.51e-05	Significant	25631445
KIRP	Kidney renal papillary cell carcinoma	161	0.00221	Significant	26536169
LGG	Brain Lower Grade Glioma	513	1.34e-05	Significant	26824661
LUAD	Lung adenocarcinoma	230	0.0407	Significant	25079552
LUSC	Lung squamous cell carcinoma	178	0.000152	Significant	22960745
OV	Ovarian serous cystadenocarcinoma	287	0.0249	Significant	21720365
PRAD	Prostate adenocarcinoma	333	5.08e-08	Significant	26544944
READ	Rectum adenocarcinoma	67	0.67	NS	22810696
SKCM	Skin Cutaneous Melanoma	315	0.00253	Significant	26091043
STAD	Stomach adenocarcinoma	277	0.204	NS	25079317
THCA	Thyroid carcinoma	391	0.335	NS	25417114
UCEC	Uterine Corpus Endometrial Carcinoma	232	1.7e-07	Significant	23636398

> Overall survival

[ TOP ]

Overall survival analysis based on expression.

Cancer	Full Name	# Patients	Hazard Ratio	P Value (Log Rank Test)	Association
BLCA	Bladder urothelial carcinoma	405	1.47	0.0722	NS
BRCA	Breast invasive carcinoma	1079	1.025	0.916	NS
CESC	Cervical and endocervical cancers	291	1.853	0.0661	NS
COAD	Colon adenocarcinoma	439	1.824	0.0397	Shorter
ESCA	Esophageal carcinoma	184	0.853	0.616	NS
GBM	Glioblastoma multiforme	158	0.765	0.311	NS
HNSC	Head and Neck squamous cell carcinoma	518	1.087	0.67	NS
KIRC	Kidney renal clear cell carcinoma	531	0.722	0.124	NS
KIRP	Kidney renal papillary cell carcinoma	287	1.366	0.451	NS
LAML	Acute Myeloid Leukemia	149	0.49	0.0232	Longer
LGG	Brain Lower Grade Glioma	511	0.848	0.548	NS
LIHC	Liver hepatocellular carcinoma	365	1.166	0.545	NS
LUAD	Lung adenocarcinoma	502	1.25	0.286	NS
LUSC	Lung squamous cell carcinoma	494	1.014	0.939	NS
OV	Ovarian serous cystadenocarcinoma	303	1.393	0.114	NS
PAAD	Pancreatic adenocarcinoma	177	0.916	0.758	NS
PCPG	Pheochromocytoma and Paraganglioma	179	569527109.525	0.167	NS
PRAD	Prostate adenocarcinoma	497	0.835	0.84	NS
READ	Rectum adenocarcinoma	159	0.562	0.289	NS
SARC	Sarcoma	259	1.182	0.548	NS
SKCM	Skin Cutaneous Melanoma	459	0.764	0.173	NS
STAD	Stomach adenocarcinoma	388	0.721	0.145	NS
TGCT	Testicular Germ Cell Tumors	134	0.625	0.7	NS
THCA	Thyroid carcinoma	500	1.268	0.755	NS
THYM	Thymoma	119	0.7	0.709	NS
UCEC	Uterine Corpus Endometrial Carcinoma	543	0.807	0.493	NS

> Stage

[ TOP ]

Association between expresson and stage.

Cancer	Full Name	# Patients	R Value (Spearman)	P Value (Spearman)	Association
BLCA	Bladder urothelial carcinoma	406	0.008	0.869	NS
BRCA	Breast invasive carcinoma	1071	-0.005	0.862	NS
CESC	Cervical and endocervical cancers	167	0.067	0.389	NS
COAD	Colon adenocarcinoma	445	-0.001	0.983	NS
ESCA	Esophageal carcinoma	162	0.026	0.742	NS
HNSC	Head and Neck squamous cell carcinoma	448	0.098	0.0373	Higher
KIRC	Kidney renal clear cell carcinoma	531	-0.006	0.889	NS
KIRP	Kidney renal papillary cell carcinoma	260	0.092	0.139	NS
LIHC	Liver hepatocellular carcinoma	347	0.146	0.00637	Higher
LUAD	Lung adenocarcinoma	507	0.071	0.112	NS
LUSC	Lung squamous cell carcinoma	497	0.027	0.545	NS
OV	Ovarian serous cystadenocarcinoma	302	-0.064	0.265	NS
PAAD	Pancreatic adenocarcinoma	176	-0.066	0.385	NS
READ	Rectum adenocarcinoma	156	-0.13	0.106	NS
SKCM	Skin Cutaneous Melanoma	410	0.018	0.719	NS
STAD	Stomach adenocarcinoma	392	0.001	0.987	NS
TGCT	Testicular Germ Cell Tumors	81	-0.196	0.0791	NS
THCA	Thyroid carcinoma	499	-0.077	0.0853	NS
UCEC	Uterine Corpus Endometrial Carcinoma	501	-0.111	0.0126	Lower

> Grade

[ TOP ]

Association between expresson and grade.

Cancer	Full Name	# Patients	R Value (Spearman)	P Value (Spearman)	Association
CESC	Cervical and endocervical cancers	272	-0.097	0.109	NS
HNSC	Head and Neck squamous cell carcinoma	498	0.126	0.00484	Higher
KIRC	Kidney renal clear cell carcinoma	525	-0.005	0.905	NS
LGG	Brain Lower Grade Glioma	514	-0.021	0.632	NS
LIHC	Liver hepatocellular carcinoma	366	0.131	0.0118	Higher
OV	Ovarian serous cystadenocarcinoma	296	0.099	0.0887	NS
PAAD	Pancreatic adenocarcinoma	176	0.101	0.182	NS
STAD	Stomach adenocarcinoma	406	-0.028	0.567	NS
UCEC	Uterine Corpus Endometrial Carcinoma	534	-0.079	0.0681	NS

Summary
Symbol	TP53BP1
Name	tumor protein p53 binding protein 1
Aliases	53BP1; p202; TDRD30; tumor protein p53-binding protein, 1; p53BP1; p53-binding protein 1; tumor protein 53-b ......
Location	15q15.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Targets inferred by reverse engineering method > Targets identified by ChIP-seq data

> Targets inferred by reverse engineering method [ TOP ]

> Targets identified by ChIP-seq data [ TOP ]

Summary
Symbol	TP53BP1
Name	tumor protein p53 binding protein 1
Aliases	53BP1; p202; TDRD30; tumor protein p53-binding protein, 1; p53BP1; p53-binding protein 1; tumor protein 53-b ......
Location	15q15.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Drugs from DrugBank database

> Drugs from DrugBank database [ TOP ]
There is no record for TP53BP1.

Summary
Symbol	TP53BP1
Name	tumor protein p53 binding protein 1
Aliases	53BP1; p202; TDRD30; tumor protein p53-binding protein, 1; p53BP1; p53-binding protein 1; tumor protein 53-b ......
Location	15q15.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Protein-Protein Interaction Network > miRNA Regulatory Relationship > Interactions from Text Mining

> Protein-Protein Interaction Network [ TOP ]

> miRNA Regulatory Relationship [ TOP ]

> Interactions from Text Mining [ TOP ]
There is no record for TP53BP1.