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This regulatory network was inferred from the input dataset. The miRNAs and mRNAs are presented as round and rectangle nodes respectively. The numerical value popped up upon mouse over the gene node is the log2 transformed fold-change of the gene expression between the two groups. All of the nodes are clickable, and the detailed information of the miRNAs/mRNAs and related cancer pathway will be displayed in another window. The edges between nodes are supported by both interactions (predicted or experimentally verified) and correlations learnt from cancer dataset. The numerical value popped up upon mouse over the edge is the correlation beat value (effect size) between the two nodes. The experimental evidences of the edges reported in previous cancer studies are highlighted by red/orange color. All of these information can be accessed by the "mouse-over" action. This network shows a full map of the miRNA-mRNA regulation of the input gene list(s), and the hub miRNAs (with the high network degree/betweenness centrality) would be the potential cancer drivers or tumor suppressors. The full result table can be accessed in the "Regulations" tab.

"miRNACancerMAP" is also a network visualization tool for users to draw their regulatory network by personal customization. Users can set the complexity of the network by limiting the number of nodes or edges. And the color of the nodes can be defined by different categories of the mRNAs and miRNAs, such as Gene-Ontology, pathway, and expression status. Users can also select to use network degree or network betweenness centrality to define the node size. And edges can be black or colored by the correlation. Purple edge means negative correlation (mostly found between miRNA and mRNA), and blue edge means positive correlation (found in PPI or miRNA-miRNA sponge effect). We can also add the protein-protein interactions (PPI) into the network. This result will show the cluster of genes regulated by some specific miRNAs. Additionally, miRNA-miRNA edges can be added by the "miRNA sponge" button, presenting some clusters of miRNAs that have the interactions via sponge effect.

miRNA-gene regulations

(Download full result)

Num microRNA           Gene miRNA log2FC miRNA pvalue Gene log2FC Gene pvalue Interaction Correlation beta Correlation P-value PMID Reported in cancer studies
1 hsa-miR-27a-5p ABAT 0.1 0.90102 0.41 0.63594 miRNATAP -0.19 0.04218 NA
2 hsa-miR-93-5p ABCA1 -0.47 0.82637 -0.04 0.9599 MirTarget; miRNATAP -0.38 0 NA
3 hsa-miR-93-5p ABCD2 -0.47 0.82637 -0.25 0.61042 MirTarget -0.6 0 NA
4 hsa-miR-93-5p ABHD2 -0.47 0.82637 0.03 0.98501 miRNATAP -0.12 0.04107 NA
5 hsa-miR-93-5p ABL2 -0.47 0.82637 0.09 0.91468 MirTarget -0.15 3.0E-5 NA
6 hsa-miR-93-5p ADAM19 -0.47 0.82637 -0.01 0.98753 mirMAP -0.3 0.00022 NA
7 hsa-miR-17-3p ADAMTS15 0.16 0.91644 -0.91 0.09979 MirTarget; miRNATAP -0.38 0.027 NA
8 hsa-miR-17-3p ADAMTSL1 0.16 0.91644 0.05 0.90541 mirMAP -0.51 0 NA
9 hsa-miR-93-5p ADARB1 -0.47 0.82637 -0.12 0.85953 miRNAWalker2 validate; MirTarget -0.28 0 NA
10 hsa-miR-93-5p ADCY1 -0.47 0.82637 0.18 0.62889 mirMAP -0.31 0.00607 NA
11 hsa-miR-93-5p ADCY9 -0.47 0.82637 -0.2 0.81596 mirMAP -0.18 0.00019 NA
12 hsa-miR-17-3p AGPAT4 0.16 0.91644 0.17 0.74406 mirMAP -0.54 0 NA
13 hsa-miR-93-5p AHNAK -0.47 0.82637 -0.12 0.93956 miRNATAP -0.46 0 NA
14 hsa-miR-93-5p AKAP13 -0.47 0.82637 -0.18 0.88348 MirTarget; miRNATAP -0.21 1.0E-5 NA
15 hsa-miR-17-3p AKT3 0.16 0.91644 0.25 0.66912 miRNATAP -0.52 0 NA
16 hsa-miR-93-5p AKT3 -0.47 0.82637 0.25 0.66912 miRNATAP -0.76 0 NA
17 hsa-miR-93-5p ALDH1A3 -0.47 0.82637 0.39 0.62184 mirMAP -0.76 0 NA
18 hsa-miR-17-3p ANGPTL1 0.16 0.91644 0.24 0.70436 MirTarget -1.51 0 NA
19 hsa-miR-93-5p ANK2 -0.47 0.82637 -0.09 0.8433 MirTarget; miRNATAP -1.16 0 NA
20 hsa-miR-93-5p ANKRD12 -0.47 0.82637 0.06 0.93991 MirTarget -0.12 0.00484 NA
21 hsa-miR-93-5p ANKRD29 -0.47 0.82637 0.64 0.08037 miRNAWalker2 validate; MirTarget -0.53 1.0E-5 NA
22 hsa-miR-17-3p ANKRD50 0.16 0.91644 0.03 0.97538 MirTarget; miRNATAP -0.23 0 NA
23 hsa-miR-93-5p ANKRD50 -0.47 0.82637 0.03 0.97538 MirTarget; miRNATAP -0.21 0 NA
24 hsa-miR-27a-5p ANTXR1 0.1 0.90102 0.14 0.90557 MirTarget -0.25 0.01093 NA
25 hsa-miR-93-5p APBB2 -0.47 0.82637 0 0.99736 miRNAWalker2 validate; MirTarget; miRNATAP -0.14 0.00474 NA
26 hsa-miR-20b-5p APCDD1 0.28 0.48508 1.11 0.282 MirTarget -0.17 0.04915 NA
27 hsa-miR-93-5p AR -0.47 0.82637 -0.38 0.58507 mirMAP -1.04 0 NA
28 hsa-miR-93-5p ARHGAP1 -0.47 0.82637 -0.11 0.93344 miRNAWalker2 validate; MirTarget; miRNATAP -0.19 0 NA
29 hsa-miR-93-5p ARHGAP23 -0.47 0.82637 0.05 0.9518 mirMAP -0.43 0 NA
30 hsa-miR-93-5p ARHGAP24 -0.47 0.82637 -0.06 0.89635 MirTarget -0.57 0 NA
31 hsa-miR-93-5p ARHGEF3 -0.47 0.82637 -0.03 0.9748 MirTarget; miRNATAP -0.16 8.0E-5 NA
32 hsa-miR-93-5p ARID4B -0.47 0.82637 0.11 0.90679 miRNAWalker2 validate; MirTarget; miRNATAP -0.1 0.00082 NA
33 hsa-miR-93-5p ARL10 -0.47 0.82637 0.01 0.96883 mirMAP -0.51 0 NA
34 hsa-miR-93-5p ARL4C -0.47 0.82637 -0.1 0.91679 MirTarget; miRNATAP -0.48 0 NA
35 hsa-miR-93-5p ARL9 -0.47 0.82637 0.42 0.51463 miRNAWalker2 validate -0.5 0.00024 NA
36 hsa-miR-93-5p ARNT2 -0.47 0.82637 -0.28 0.615 mirMAP -0.44 0.00083 NA
37 hsa-miR-20b-5p ARSD 0.28 0.48508 -0.06 0.95634 mirMAP -0.1 0.01104 NA
38 hsa-miR-93-5p ASPA -0.47 0.82637 0.11 0.88022 mirMAP -0.8 0 NA
39 hsa-miR-17-3p ASTN1 0.16 0.91644 0.28 0.76516 MirTarget -0.97 0 NA
40 hsa-miR-93-5p ATCAY -0.47 0.82637 0.67 0.44599 mirMAP -1.02 0 NA
41 hsa-miR-93-5p ATP1A2 -0.47 0.82637 -0.04 0.95085 MirTarget -1.89 0 NA
42 hsa-miR-93-5p ATXN1 -0.47 0.82637 0.04 0.96341 miRNAWalker2 validate; miRNATAP -0.25 0 NA
43 hsa-miR-93-5p ATXN1L -0.47 0.82637 -0.1 0.92096 miRNATAP -0.11 0.00036 NA
44 hsa-miR-93-5p BAG2 -0.47 0.82637 0.07 0.91567 miRNAWalker2 validate -0.27 0.01276 NA
45 hsa-miR-93-5p BBX -0.47 0.82637 0.02 0.9851 MirTarget; miRNATAP -0.13 0.00012 NA
46 hsa-miR-17-3p BCL9L 0.16 0.91644 0.02 0.98781 mirMAP -0.12 0.00261 NA
47 hsa-miR-93-5p BEND4 -0.47 0.82637 -0.11 0.88946 mirMAP -0.58 4.0E-5 NA
48 hsa-miR-93-5p BHLHE41 -0.47 0.82637 0.52 0.4886 miRNATAP -0.6 0 NA
49 hsa-miR-93-5p BMPR2 -0.47 0.82637 0.12 0.90786 miRNAWalker2 validate; MirTarget; miRNATAP -0.29 0 NA
50 hsa-miR-93-5p BNC2 -0.47 0.82637 0.15 0.76233 miRNATAP -1.05 0 NA
51 hsa-miR-93-5p BNIP2 -0.47 0.82637 0.08 0.92524 miRNAWalker2 validate; MirTarget; miRNATAP -0.13 0.00059 NA
52 hsa-miR-93-5p BNIP3L -0.47 0.82637 -0.4 0.70779 MirTarget -0.12 0.04888 NA
53 hsa-miR-17-3p BTBD7 0.16 0.91644 -0.13 0.8883 miRNATAP -0.11 0.00049 NA
54 hsa-miR-17-3p C15orf52 0.16 0.91644 -0.08 0.91072 mirMAP -0.24 0.00136 NA
55 hsa-miR-17-3p C1orf21 0.16 0.91644 -0.11 0.91205 mirMAP -0.18 0.0105 NA
56 hsa-miR-93-5p CA5B -0.47 0.82637 -0.22 0.62382 mirMAP -0.15 0.0047 NA
57 hsa-miR-17-3p CACNA1E 0.16 0.91644 -0.51 0.36647 miRNATAP -0.51 0.00035 NA
58 hsa-miR-93-5p CACNA1E -0.47 0.82637 -0.51 0.36647 mirMAP -0.62 4.0E-5 NA
59 hsa-miR-93-5p CADM2 -0.47 0.82637 0.76 0.4386 miRNATAP -0.87 0 NA
60 hsa-miR-93-5p CALD1 -0.47 0.82637 0.13 0.92312 miRNATAP -0.76 0 NA
61 hsa-miR-93-5p CAMTA2 -0.47 0.82637 -0.01 0.99321 MirTarget -0.12 0.00446 NA
62 hsa-miR-93-5p CAV2 -0.47 0.82637 0.18 0.80695 miRNAWalker2 validate -0.48 0 NA
63 hsa-miR-93-5p CBX7 -0.47 0.82637 -0.06 0.9429 mirMAP -0.4 0 NA
64 hsa-miR-93-5p CCBE1 -0.47 0.82637 -0.02 0.97818 mirMAP -1.43 0 NA
65 hsa-miR-93-5p CCNG2 -0.47 0.82637 -0.04 0.96901 miRNAWalker2 validate; MirTarget; miRNATAP -0.14 0.00129 NA
66 hsa-miR-93-5p CD274 -0.47 0.82637 -0.02 0.95972 MirTarget; miRNATAP -0.28 0.01757 NA
67 hsa-miR-93-5p CD69 -0.47 0.82637 -0.08 0.84476 miRNATAP -0.28 0.0202 NA
68 hsa-miR-17-3p CDK17 0.16 0.91644 -0.03 0.96463 MirTarget; miRNATAP -0.17 0 NA
69 hsa-miR-17-3p CDO1 0.16 0.91644 0.35 0.55727 MirTarget -0.94 0 NA
70 hsa-miR-27a-5p CELF5 0.1 0.90102 -0.59 0.21561 mirMAP -0.35 0.00432 NA
71 hsa-miR-93-5p CEP170 -0.47 0.82637 -0.01 0.98675 MirTarget -0.28 0 NA
72 hsa-miR-93-5p CERCAM -0.47 0.82637 -0.1 0.9115 MirTarget -0.54 0 NA
73 hsa-miR-93-5p CFL2 -0.47 0.82637 -0.06 0.92086 MirTarget; miRNATAP -0.56 0 NA
74 hsa-miR-93-5p CHD5 -0.47 0.82637 0.31 0.59864 MirTarget; miRNATAP -0.44 0.00093 NA
75 hsa-miR-93-5p CHD9 -0.47 0.82637 -0.03 0.975 MirTarget; miRNATAP -0.16 8.0E-5 NA
76 hsa-miR-93-5p CIC -0.47 0.82637 -0.14 0.89104 miRNATAP -0.11 0.00079 NA
77 hsa-miR-17-3p CLIP3 0.16 0.91644 0.02 0.96975 miRNATAP -0.7 0 NA
78 hsa-miR-27a-5p CLIP3 0.1 0.90102 0.02 0.96975 miRNATAP -0.3 2.0E-5 NA
79 hsa-miR-93-5p CLIP4 -0.47 0.82637 -0.05 0.8934 MirTarget -0.93 0 NA
80 hsa-miR-93-5p CNTNAP3 -0.47 0.82637 -0.26 0.63022 MirTarget -0.87 0 NA
81 hsa-miR-17-3p COL12A1 0.16 0.91644 0.04 0.97928 MirTarget; miRNATAP -0.37 0.00016 NA
82 hsa-miR-93-5p COL1A1 -0.47 0.82637 -0.12 0.95162 mirMAP -0.61 0 NA
83 hsa-miR-93-5p COL4A3 -0.47 0.82637 -0.34 0.65324 MirTarget; miRNATAP -0.55 0.00189 NA
84 hsa-miR-27a-5p COL9A3 0.1 0.90102 1.04 0.13989 MirTarget -0.34 0.01397 NA
85 hsa-miR-93-5p CORO2B -0.47 0.82637 0.6 0.10777 MirTarget; miRNATAP -0.86 0 NA
86 hsa-miR-93-5p CPEB3 -0.47 0.82637 -0.04 0.91989 miRNATAP -0.13 0.00426 NA
87 hsa-miR-17-3p CPNE8 0.16 0.91644 -0.04 0.92677 MirTarget -0.22 0.00808 NA
88 hsa-miR-93-5p CREB5 -0.47 0.82637 0.4 0.40036 MirTarget; miRNATAP -0.3 0.00588 NA
89 hsa-miR-93-5p CRIM1 -0.47 0.82637 0.05 0.96442 MirTarget; miRNATAP -0.14 0.00157 NA
90 hsa-miR-93-5p CRY2 -0.47 0.82637 -0.03 0.9668 miRNAWalker2 validate; MirTarget; miRNATAP -0.17 0 NA
91 hsa-miR-93-5p CRYBG3 -0.47 0.82637 -0.13 0.83349 MirTarget; miRNATAP -0.26 1.0E-5 NA
92 hsa-miR-93-5p CSF1 -0.47 0.82637 -0.08 0.9101 miRNATAP -0.45 0 NA
93 hsa-miR-93-5p CSGALNACT1 -0.47 0.82637 0.26 0.68074 MirTarget -0.34 2.0E-5 NA
94 hsa-miR-93-5p CTSK -0.47 0.82637 0.03 0.97917 MirTarget -0.56 0 NA
95 hsa-miR-93-5p CXorf36 -0.47 0.82637 0.13 0.80812 mirMAP -0.53 0 NA
96 hsa-miR-93-5p CYBRD1 -0.47 0.82637 0.11 0.90715 MirTarget -0.82 0 NA
97 hsa-miR-93-5p CYP26B1 -0.47 0.82637 0.59 0.14311 miRNATAP -0.4 0.00065 NA
98 hsa-miR-93-5p CYP2U1 -0.47 0.82637 -0.07 0.89867 MirTarget -0.29 1.0E-5 NA
99 hsa-miR-17-3p CYTH3 0.16 0.91644 0.04 0.96043 MirTarget -0.12 0.00765 NA
100 hsa-miR-27a-5p CYTH3 0.1 0.90102 0.04 0.96043 mirMAP -0.13 0.00055 NA
101 hsa-miR-93-5p DAB2 -0.47 0.82637 0.14 0.89972 MirTarget; miRNATAP -0.2 0.0041 24037530 miR 93 directed downregulation of DAB2 defines a novel oncogenic pathway in lung cancer; We next identify that microRNA miR-93 functions as a potent repressor of DAB2 expression by directly targeting the 3'UTR of the DAB2 mRNA; Using in vitro and in vivo approaches we demonstrate that miR-93 overexpression has an important role in promoting lung cancer cell growth and that its oncogenic function is primarily mediated by downregulating DAB2 expression; The correlations of both low DAB2 and high miR-93 expression levels with poor patient survival strongly support the critical role of the miR-93/DAB2 pathway in determining lung cancer progression
102 hsa-miR-93-5p DCBLD2 -0.47 0.82637 0 0.99929 MirTarget; miRNATAP -0.33 0.0001 NA
103 hsa-miR-17-3p DCLK1 0.16 0.91644 0.01 0.98653 MirTarget; miRNATAP -0.87 0 NA
104 hsa-miR-93-5p DENND5B -0.47 0.82637 0.03 0.95555 MirTarget; miRNATAP -0.21 0.00657 NA
105 hsa-miR-93-5p DIXDC1 -0.47 0.82637 -0.07 0.91444 mirMAP -0.45 0 NA
106 hsa-miR-27a-5p DLG2 0.1 0.90102 0.05 0.9264 miRNATAP -0.46 5.0E-5 NA
107 hsa-miR-93-5p DMKN -0.47 0.82637 -0.47 0.50996 miRNAWalker2 validate -0.49 0.00546 NA
108 hsa-miR-17-3p DNAJC18 0.16 0.91644 -0.13 0.72848 MirTarget -0.21 0 NA
109 hsa-miR-93-5p DOCK4 -0.47 0.82637 0.02 0.97023 MirTarget -0.26 0.00199 NA
110 hsa-miR-17-3p DOK6 0.16 0.91644 0.12 0.7148 MirTarget -0.6 0 NA
111 hsa-miR-17-3p DPT 0.16 0.91644 0.19 0.76162 MirTarget -1.1 0 NA
112 hsa-miR-93-5p DPYD -0.47 0.82637 0.07 0.90718 MirTarget -0.77 0 NA
113 hsa-miR-93-5p DPYSL2 -0.47 0.82637 -0.16 0.88622 MirTarget; miRNATAP -0.23 0.00484 NA
114 hsa-miR-17-3p DST 0.16 0.91644 0.06 0.96207 mirMAP; miRNATAP -0.26 0 NA
115 hsa-miR-93-5p DST -0.47 0.82637 0.06 0.96207 mirMAP -0.33 0 NA
116 hsa-miR-93-5p DSTYK -0.47 0.82637 -0.05 0.951 miRNAWalker2 validate; miRNATAP -0.18 0 NA
117 hsa-miR-17-3p DUSP19 0.16 0.91644 -0.03 0.90206 mirMAP -0.2 2.0E-5 NA
118 hsa-miR-17-3p EBF1 0.16 0.91644 0.25 0.44838 MirTarget; miRNATAP -0.48 0 NA
119 hsa-miR-93-5p ECE1 -0.47 0.82637 0.12 0.92902 mirMAP -0.17 0.00025 NA
120 hsa-miR-93-5p EDA2R -0.47 0.82637 0.27 0.45282 MirTarget -0.51 2.0E-5 NA
121 hsa-miR-93-5p EGR2 -0.47 0.82637 0.02 0.9747 miRNAWalker2 validate; MirTarget; miRNATAP -0.62 0 NA
122 hsa-miR-17-3p EHD3 0.16 0.91644 0.21 0.66734 MirTarget -0.31 2.0E-5 NA
123 hsa-miR-93-5p ELAVL2 -0.47 0.82637 1.49 0.03805 MirTarget; miRNATAP -0.45 0.02718 NA
124 hsa-miR-17-3p ELFN2 0.16 0.91644 0.07 0.88599 mirMAP -0.55 0.00028 NA
125 hsa-miR-93-5p ELK3 -0.47 0.82637 0.03 0.96415 MirTarget; miRNATAP -0.44 0 NA
126 hsa-miR-17-3p ELOVL2 0.16 0.91644 0.16 0.75946 miRNAWalker2 validate -0.35 0.0017 NA
127 hsa-miR-17-3p ENTPD1 0.16 0.91644 -0.08 0.93919 mirMAP -0.24 0 NA
128 hsa-miR-93-5p EPAS1 -0.47 0.82637 0.02 0.98754 miRNATAP -0.25 0 NA
129 hsa-miR-93-5p EPHA4 -0.47 0.82637 -0.07 0.90219 miRNAWalker2 validate; miRNATAP -0.7 0 NA
130 hsa-miR-93-5p EPHA7 -0.47 0.82637 0.16 0.77187 miRNAWalker2 validate; miRNATAP -0.89 0 NA
131 hsa-miR-93-5p ETV1 -0.47 0.82637 0.09 0.87424 MirTarget; miRNATAP -0.34 4.0E-5 NA
132 hsa-miR-93-5p FAM117A -0.47 0.82637 -0.04 0.94562 miRNATAP -0.11 0.03928 NA
133 hsa-miR-93-5p FAM129A -0.47 0.82637 0.07 0.91871 miRNAWalker2 validate -0.84 0 NA
134 hsa-miR-17-3p FAM19A1 0.16 0.91644 -0.08 0.89505 MirTarget -0.52 8.0E-5 NA
135 hsa-miR-93-5p FAM19A1 -0.47 0.82637 -0.08 0.89505 MirTarget -0.53 0.00016 NA
136 hsa-miR-93-5p FAT3 -0.47 0.82637 0.26 0.59295 mirMAP -0.81 0 NA
137 hsa-miR-93-5p FAT4 -0.47 0.82637 -0.14 0.82442 MirTarget; miRNATAP -0.58 0 NA
138 hsa-miR-93-5p FBXL5 -0.47 0.82637 0.06 0.95442 miRNAWalker2 validate; miRNATAP -0.15 0 NA
139 hsa-miR-93-5p FGD1 -0.47 0.82637 0.03 0.95404 MirTarget; miRNATAP -0.2 0.02482 NA
140 hsa-miR-93-5p FGD5 -0.47 0.82637 0.06 0.93238 MirTarget; miRNATAP -0.49 0 NA
141 hsa-miR-93-5p FGFR1 -0.47 0.82637 -0 0.99975 mirMAP -0.67 0 NA
142 hsa-miR-93-5p FGL2 -0.47 0.82637 -0.4 0.60105 MirTarget -0.52 0 NA
143 hsa-miR-93-5p FIBIN -0.47 0.82637 0.31 0.61256 MirTarget -0.76 0 NA
144 hsa-miR-93-5p FKBP7 -0.47 0.82637 0.07 0.89678 miRNAWalker2 validate -0.32 0 NA
145 hsa-miR-93-5p FLT1 -0.47 0.82637 0.22 0.79856 MirTarget; miRNATAP -0.29 0 NA
146 hsa-miR-27a-5p FN1 0.1 0.90102 0.13 0.94049 MirTarget -0.35 0.00209 NA
147 hsa-miR-17-3p FOSL2 0.16 0.91644 -0.14 0.89993 mirMAP -0.11 0.02297 NA
148 hsa-miR-17-3p FOXP1 0.16 0.91644 -0.25 0.81645 MirTarget; miRNATAP -0.17 0.00025 NA
149 hsa-miR-17-3p FOXP3 0.16 0.91644 -0.38 0.33932 MirTarget -0.31 0.00274 NA
150 hsa-miR-20b-5p FOXQ1 0.28 0.48508 0.46 0.63909 MirTarget -0.17 0.01371 NA

Over-represented Gene Ontology Biological Process

NumGOOverlapSizeP ValueAdj. P Value
1 CELL DEVELOPMENT 80 1426 1.298e-11 6.041e-08
2 NEUROGENESIS 78 1402 3.665e-11 8.527e-08
3 CELL MORPHOGENESIS INVOLVED IN DIFFERENTIATION 41 513 9.394e-11 1.457e-07
4 POSITIVE REGULATION OF GENE EXPRESSION 87 1733 4.541e-10 4.454e-07
5 CENTRAL NERVOUS SYSTEM DEVELOPMENT 55 872 4.786e-10 4.454e-07
6 TISSUE DEVELOPMENT 79 1518 6.454e-10 5.005e-07
7 REGULATION OF CELL DIFFERENTIATION 77 1492 1.608e-09 1.069e-06
8 POSITIVE REGULATION OF CELL MORPHOGENESIS INVOLVED IN DIFFERENTIATION 20 162 5.555e-09 3.231e-06
9 REGULATION OF ANATOMICAL STRUCTURE MORPHOGENESIS 58 1021 7.592e-09 3.925e-06
10 NEURON DIFFERENTIATION 52 874 1.068e-08 4.968e-06
11 REGULATION OF CELL DEVELOPMENT 50 836 1.769e-08 7.483e-06
12 SKELETAL SYSTEM DEVELOPMENT 34 455 2.136e-08 8.282e-06
13 REGULATION OF MULTICELLULAR ORGANISMAL DEVELOPMENT 79 1672 4.711e-08 1.686e-05
14 ORGAN MORPHOGENESIS 49 841 5.593e-08 1.735e-05
15 POSITIVE REGULATION OF CELL DEVELOPMENT 34 472 5.223e-08 1.735e-05
16 POSITIVE REGULATION OF BIOSYNTHETIC PROCESS 83 1805 6.665e-08 1.824e-05
17 POSITIVE REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 55 1004 6.503e-08 1.824e-05
18 CELLULAR COMPONENT MORPHOGENESIS 51 900 7.103e-08 1.836e-05
19 CELL MORPHOGENESIS INVOLVED IN NEURON DIFFERENTIATION 29 368 7.668e-08 1.878e-05
20 REGULATION OF CELL MORPHOGENESIS 37 552 8.494e-08 1.976e-05
21 REGULATION OF NEURON DIFFERENTIATION 37 554 9.307e-08 2.062e-05
22 NEURON PROJECTION MORPHOGENESIS 30 402 1.509e-07 3.193e-05
23 REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 81 1784 1.686e-07 3.411e-05
24 REGULATION OF NERVOUS SYSTEM DEVELOPMENT 44 750 2.287e-07 4.257e-05
25 REGULATION OF GTPASE ACTIVITY 41 673 2.243e-07 4.257e-05
26 REGULATION OF INTRACELLULAR SIGNAL TRANSDUCTION 76 1656 2.842e-07 4.729e-05
27 MOVEMENT OF CELL OR SUBCELLULAR COMPONENT 63 1275 2.806e-07 4.729e-05
28 REGULATION OF SYSTEM PROCESS 34 507 2.846e-07 4.729e-05
29 REGULATION OF CELL PROJECTION ORGANIZATION 36 558 3.234e-07 5.133e-05
30 HEAD DEVELOPMENT 42 709 3.369e-07 5.133e-05
31 CARDIOVASCULAR SYSTEM DEVELOPMENT 45 788 3.53e-07 5.133e-05
32 CIRCULATORY SYSTEM DEVELOPMENT 45 788 3.53e-07 5.133e-05
33 POSITIVE REGULATION OF MOLECULAR FUNCTION 80 1791 3.97e-07 5.598e-05
34 POSITIVE REGULATION OF CELL DIFFERENTIATION 46 823 4.764e-07 6.52e-05
35 REGULATION OF CELL MORPHOGENESIS INVOLVED IN DIFFERENTIATION 26 337 5.458e-07 7.256e-05
36 INTRACELLULAR SIGNAL TRANSDUCTION 72 1572 6.611e-07 8.409e-05
37 REGULATION OF NEURON PROJECTION DEVELOPMENT 29 408 6.687e-07 8.409e-05
38 REGULATION OF SMALL GTPASE MEDIATED SIGNAL TRANSDUCTION 23 278 7.413e-07 9.077e-05
39 CARTILAGE DEVELOPMENT 16 147 1.057e-06 0.0001261
40 POSITIVE REGULATION OF NEURON DIFFERENTIATION 24 306 1.113e-06 0.0001295
41 POSITIVE REGULATION OF HYDROLASE ACTIVITY 48 905 1.189e-06 0.0001344
42 REGULATION OF CELLULAR COMPONENT MOVEMENT 43 771 1.213e-06 0.0001344
43 VASCULATURE DEVELOPMENT 31 469 1.304e-06 0.0001411
44 POSITIVE REGULATION OF CATALYTIC ACTIVITY 69 1518 1.528e-06 0.0001616
45 TELENCEPHALON DEVELOPMENT 20 228 1.587e-06 0.0001641
46 REGULATION OF PHOSPHORUS METABOLIC PROCESS 72 1618 1.9e-06 0.0001892
47 BIOLOGICAL ADHESION 52 1032 1.911e-06 0.0001892
48 POSITIVE REGULATION OF NEURON PROJECTION DEVELOPMENT 20 232 2.077e-06 0.0002014
49 CONNECTIVE TISSUE DEVELOPMENT 18 194 2.37e-06 0.000225
50 NEURON DEVELOPMENT 39 687 2.534e-06 0.0002329
51 CEREBRAL CORTEX DEVELOPMENT 13 105 2.552e-06 0.0002329
52 POSITIVE REGULATION OF NERVOUS SYSTEM DEVELOPMENT 29 437 2.655e-06 0.0002375
53 POSITIVE REGULATION OF CELL PROJECTION ORGANIZATION 23 303 3.236e-06 0.0002841
54 POSITIVE REGULATION OF LOCOMOTION 28 420 3.618e-06 0.0003117
55 POSITIVE REGULATION OF DEVELOPMENTAL PROCESS 55 1142 3.701e-06 0.0003131
56 EPITHELIUM DEVELOPMENT 48 945 3.916e-06 0.0003201
57 NEURON PROJECTION DEVELOPMENT 33 545 3.99e-06 0.0003201
58 SKELETAL SYSTEM MORPHOGENESIS 18 201 3.923e-06 0.0003201
59 REGULATION OF HYDROLASE ACTIVITY 61 1327 4.657e-06 0.0003558
60 POSITIVE REGULATION OF PHOSPHATE METABOLIC PROCESS 51 1036 4.664e-06 0.0003558
61 POSITIVE REGULATION OF PHOSPHORUS METABOLIC PROCESS 51 1036 4.664e-06 0.0003558
62 REGULATION OF RAS PROTEIN SIGNAL TRANSDUCTION 17 184 4.77e-06 0.000358
63 MEMBRANE DEPOLARIZATION DURING ACTION POTENTIAL 8 39 4.971e-06 0.0003671
64 MUSCLE STRUCTURE DEVELOPMENT 28 432 6.164e-06 0.0004482
65 REGULATION OF CELLULAR RESPONSE TO GROWTH FACTOR STIMULUS 19 229 6.51e-06 0.000466
66 MUSCLE TISSUE DEVELOPMENT 21 275 7.861e-06 0.0005527
67 LOCOMOTION 53 1114 7.959e-06 0.0005527
68 POSITIVE REGULATION OF AXONOGENESIS 10 69 8.922e-06 0.0006105
69 BEHAVIOR 31 516 9.159e-06 0.0006176
70 BONE DEVELOPMENT 15 156 1.061e-05 0.0007053
71 POSITIVE REGULATION OF CELL COMMUNICATION 66 1532 1.53e-05 0.001003
72 ENZYME LINKED RECEPTOR PROTEIN SIGNALING PATHWAY 37 689 1.588e-05 0.001026
73 RESPONSE TO ENDOGENOUS STIMULUS 63 1450 1.885e-05 0.001194
74 POSITIVE REGULATION OF AUTOPHAGY 10 75 1.899e-05 0.001194
75 POSITIVE REGULATION OF MULTICELLULAR ORGANISMAL PROCESS 61 1395 2.142e-05 0.001329
76 NEURON MIGRATION 12 110 2.288e-05 0.001382
77 REGULATION OF BLOOD CIRCULATION 21 295 2.272e-05 0.001382
78 HEART DEVELOPMENT 28 466 2.473e-05 0.001475
79 ANATOMICAL STRUCTURE FORMATION INVOLVED IN MORPHOGENESIS 46 957 2.535e-05 0.001493
80 REGULATION OF AXONOGENESIS 15 168 2.572e-05 0.001496
81 SENSORY ORGAN DEVELOPMENT 29 493 2.623e-05 0.001507
82 POSITIVE REGULATION OF AXON EXTENSION 7 36 2.847e-05 0.001616
83 NEGATIVE REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 38 740 3.256e-05 0.001826
84 EMBRYO DEVELOPMENT ENDING IN BIRTH OR EGG HATCHING 31 554 3.618e-05 0.001961
85 CELLULAR RESPONSE TO OXYGEN CONTAINING COMPOUND 40 799 3.566e-05 0.001961
86 PALLIUM DEVELOPMENT 14 153 3.624e-05 0.001961
87 POSITIVE REGULATION OF RESPONSE TO STIMULUS 77 1929 4.007e-05 0.002143
88 FOREBRAIN DEVELOPMENT 23 357 4.533e-05 0.002389
89 TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 37 724 4.577e-05 0.002389
90 EMBRYO DEVELOPMENT 43 894 4.62e-05 0.002389
91 SINGLE ORGANISM BEHAVIOR 24 384 5.042e-05 0.002563
92 REGULATION OF EXTENT OF CELL GROWTH 11 101 5.068e-05 0.002563
93 REGULATION OF DEVELOPMENTAL GROWTH 20 289 5.268e-05 0.002636
94 BLOOD VESSEL MORPHOGENESIS 23 364 6.101e-05 0.00302
95 EMBRYONIC SKELETAL SYSTEM DEVELOPMENT 12 122 6.419e-05 0.003144
96 MULTICELLULAR ORGANISMAL SIGNALING 12 123 6.952e-05 0.00337
97 NEURON PROJECTION GUIDANCE 16 205 7.207e-05 0.003457
98 REGULATION OF PROTEIN MODIFICATION PROCESS 69 1710 7.656e-05 0.003635
99 TRANSMEMBRANE RECEPTOR PROTEIN TYROSINE KINASE SIGNALING PATHWAY 28 498 7.908e-05 0.003717
100 CELL PART MORPHOGENESIS 33 633 8.093e-05 0.003764
101 TUBE DEVELOPMENT 30 552 8.169e-05 0.003764
102 ACTIN FILAMENT BASED PROCESS 26 450 9.129e-05 0.004164
103 SMALL GTPASE MEDIATED SIGNAL TRANSDUCTION 22 352 0.0001028 0.004637
104 POSITIVE REGULATION OF PROTEIN MODIFICATION PROCESS 50 1135 0.0001037 0.004637
105 VASCULOGENESIS 8 59 0.0001149 0.005094
106 CELL PROJECTION ORGANIZATION 42 902 0.0001162 0.0051
107 EMBRYONIC SKELETAL SYSTEM MORPHOGENESIS 10 93 0.0001233 0.005312
108 MUSCLE CELL DIFFERENTIATION 17 237 0.0001227 0.005312
109 CHONDROCYTE DIFFERENTIATION 8 60 0.0001297 0.005487
110 REGULATION OF CELL SIZE 14 172 0.0001292 0.005487
111 MEMBRANE DEPOLARIZATION 8 61 0.000146 0.006067
112 POSITIVE REGULATION OF STEM CELL PROLIFERATION 8 61 0.000146 0.006067
113 TAXIS 26 464 0.0001492 0.006143
114 CELLULAR RESPONSE TO ACID CHEMICAL 14 175 0.0001551 0.006268
115 CELLULAR RESPONSE TO ORGANIC SUBSTANCE 72 1848 0.0001553 0.006268
116 PROTEIN PHOSPHORYLATION 43 944 0.0001563 0.006268
117 CELLULAR RESPONSE TO ENDOGENOUS STIMULUS 45 1008 0.0001727 0.006811
118 BONE MORPHOGENESIS 9 79 0.0001717 0.006811
119 POSITIVE REGULATION OF DEVELOPMENTAL GROWTH 13 156 0.0001765 0.006903
120 POSITIVE REGULATION OF CELL DEATH 31 605 0.00018 0.006981
121 REGULATION OF KINASE ACTIVITY 37 776 0.0001868 0.007125
122 REGULATION OF OSSIFICATION 14 178 0.0001854 0.007125
123 POSITIVE REGULATION OF EPITHELIAL TO MESENCHYMAL TRANSITION 6 34 0.0001895 0.007126
124 CELL MOTILITY 39 835 0.0001914 0.007126
125 LOCALIZATION OF CELL 39 835 0.0001914 0.007126
126 REGULATION OF MEMBRANE POTENTIAL 21 343 0.000195 0.0072
127 REGULATION OF PHOSPHOLIPASE ACTIVITY 8 64 0.0002054 0.007526
128 CARDIAC MUSCLE TISSUE DEVELOPMENT 12 140 0.0002391 0.008693
129 PERIPHERAL NERVOUS SYSTEM NEURON DIFFERENTIATION 4 13 0.0002432 0.008705
130 PERIPHERAL NERVOUS SYSTEM NEURON DEVELOPMENT 4 13 0.0002432 0.008705
131 TISSUE MORPHOGENESIS 28 533 0.0002454 0.008715
132 NEGATIVE REGULATION OF GENE EXPRESSION 60 1493 0.0002602 0.009172
133 POSITIVE REGULATION OF KINASE ACTIVITY 26 482 0.0002705 0.009462
134 REGULATION OF ION TRANSPORT 30 592 0.0002752 0.009486
135 REGULATION OF CELL PROLIFERATION 60 1496 0.0002742 0.009486
NumGOOverlapSizeP ValueAdj. P Value
1 CYTOSKELETAL PROTEIN BINDING 50 819 9.127e-09 8.479e-06
2 ENZYME BINDING 81 1737 5.444e-08 2.529e-05
3 RNA POLYMERASE II TRANSCRIPTION FACTOR ACTIVITY SEQUENCE SPECIFIC DNA BINDING 39 629 2.864e-07 6.763e-05
4 NUCLEIC ACID BINDING TRANSCRIPTION FACTOR ACTIVITY 60 1199 3.64e-07 6.763e-05
5 TRANSCRIPTION FACTOR ACTIVITY RNA POLYMERASE II CORE PROMOTER PROXIMAL REGION SEQUENCE SPECIFIC BINDING 26 328 3.244e-07 6.763e-05
6 GUANYL NUCLEOTIDE EXCHANGE FACTOR ACTIVITY 24 303 9.342e-07 0.0001311
7 SEQUENCE SPECIFIC DNA BINDING 53 1037 9.878e-07 0.0001311
8 TRANSCRIPTIONAL ACTIVATOR ACTIVITY RNA POLYMERASE II CORE PROMOTER PROXIMAL REGION SEQUENCE SPECIFIC BINDING 20 226 1.383e-06 0.0001606
9 TUBULIN BINDING 22 273 1.995e-06 0.0002059
10 TRANSMEMBRANE RECEPTOR PROTEIN KINASE ACTIVITY 11 81 6.093e-06 0.0004777
11 TRANSCRIPTIONAL ACTIVATOR ACTIVITY RNA POLYMERASE II TRANSCRIPTION REGULATORY REGION SEQUENCE SPECIFIC BINDING 23 315 6.17e-06 0.0004777
12 RAS GUANYL NUCLEOTIDE EXCHANGE FACTOR ACTIVITY 19 228 6.11e-06 0.0004777
13 VOLTAGE GATED SODIUM CHANNEL ACTIVITY 6 20 7.38e-06 0.0005274
14 REGULATORY REGION NUCLEIC ACID BINDING 42 818 1.249e-05 0.0008286
15 PROTEIN HOMODIMERIZATION ACTIVITY 38 722 1.904e-05 0.001179
16 MACROMOLECULAR COMPLEX BINDING 61 1399 2.332e-05 0.001354
17 PROTEIN KINASE ACTIVITY 34 640 4.359e-05 0.002382
18 CALCIUM ION BINDING 36 697 4.668e-05 0.002409
19 MOLECULAR FUNCTION REGULATOR 58 1353 6.036e-05 0.002951
20 GTPASE BINDING 20 295 7.006e-05 0.003099
21 GROWTH FACTOR BINDING 12 123 6.952e-05 0.003099
22 KINASE ACTIVITY 40 842 0.0001111 0.004691
23 RIBONUCLEOTIDE BINDING 72 1860 0.0001886 0.007616
24 TRANSMEMBRANE RECEPTOR PROTEIN TYROSINE KINASE ACTIVITY 8 64 0.0002054 0.007633
25 MICROTUBULE BINDING 15 201 0.0001973 0.007633
26 HORMONE BINDING 8 65 0.0002291 0.008187
27 BETA CATENIN BINDING 9 84 0.0002746 0.00945
NumGOOverlapSizeP ValueAdj. P Value
1 NEURON PROJECTION 58 942 3.865e-10 2.257e-07
2 NEURON PART 67 1265 7.795e-09 2.276e-06
3 CELL PROJECTION 83 1786 4.198e-08 8.173e-06
4 MEMBRANE REGION 56 1134 1.397e-06 0.0002039
5 SITE OF POLARIZED GROWTH 15 149 6.058e-06 0.0007076
6 VOLTAGE GATED SODIUM CHANNEL COMPLEX 5 14 1.7e-05 0.001419
7 MEMBRANE MICRODOMAIN 21 288 1.587e-05 0.001419
8 CELL JUNCTION 53 1151 1.966e-05 0.001435
9 AXON 26 418 2.682e-05 0.00174
10 CELL LEADING EDGE 23 350 3.337e-05 0.001949
11 EXCITATORY SYNAPSE 16 197 4.474e-05 0.002058
12 SODIUM CHANNEL COMPLEX 5 17 4.934e-05 0.002058
13 CYTOSKELETON 78 1967 4.431e-05 0.002058
14 SYNAPSE 38 754 4.863e-05 0.002058
15 PLASMA MEMBRANE REGION 44 929 5.395e-05 0.0021
16 PLASMA MEMBRANE RAFT 10 86 6.327e-05 0.002309
17 T TUBULE 7 45 0.0001271 0.004318
18 SOMATODENDRITIC COMPARTMENT 33 650 0.0001331 0.004318
19 CELL PROJECTION PART 43 946 0.0001636 0.005029
20 SYNAPSE PART 31 610 0.000208 0.006073
21 CELL SUBSTRATE JUNCTION 23 398 0.0002286 0.006226
22 DENDRITE 25 451 0.0002345 0.006226
23 POSTSYNAPSE 22 378 0.0002818 0.007155
24 CONTRACTILE FIBER 15 211 0.0003332 0.007424
25 PROTEINACEOUS EXTRACELLULAR MATRIX 21 356 0.000322 0.007424
26 EXTRACELLULAR MATRIX COMPONENT 11 125 0.0003432 0.007424
27 ANCHORING JUNCTION 26 489 0.0003374 0.007424

Over-represented Pathway

NumPathwayPathviewOverlapSizeP ValueAdj. P Value
1 Hippo_signaling_pathway_multiple_species_hsa04392 7 29 6.207e-06 0.0003228
2 PI3K_Akt_signaling_pathway_hsa04151 23 352 3.645e-05 0.0009478
3 Phospholipase_D_signaling_pathway_hsa04072 12 146 0.0003524 0.005008
4 MAPK_signaling_pathway_hsa04010 18 295 0.0005693 0.005008
5 Hippo_signaling_pathway_hsa04390 12 154 0.0005713 0.005008
6 Focal_adhesion_hsa04510 14 199 0.0005778 0.005008
7 ECM_receptor_interaction_hsa04512 8 82 0.001113 0.008265
8 Endocytosis_hsa04144 15 244 0.001482 0.009634
9 Rap1_signaling_pathway_hsa04015 13 206 0.002383 0.01297
10 Ras_signaling_pathway_hsa04014 14 232 0.002494 0.01297
11 Regulation_of_actin_cytoskeleton_hsa04810 12 208 0.006987 0.03303
12 Apelin_signaling_pathway_hsa04371 9 137 0.008271 0.03584
13 FoxO_signaling_pathway_hsa04068 8 132 0.01936 0.07744
14 cGMP_PKG_signaling_pathway_hsa04022 9 163 0.02339 0.08688
15 Sphingolipid_signaling_pathway_hsa04071 7 118 0.03073 0.1065
16 TGF_beta_signaling_pathway_hsa04350 5 84 0.06223 0.1903
17 Signaling_pathways_regulating_pluripotency_of_stem_cells_hsa04550 7 139 0.06396 0.1903
18 cAMP_signaling_pathway_hsa04024 9 198 0.06587 0.1903
19 Cytokine_cytokine_receptor_interaction_hsa04060 11 270 0.08375 0.2278
20 AMPK_signaling_pathway_hsa04152 6 121 0.08762 0.2278
21 Calcium_signaling_pathway_hsa04020 8 182 0.0926 0.2293
22 Autophagy_animal_hsa04140 6 128 0.1073 0.2393
23 Adherens_junction_hsa04520 4 72 0.11 0.2393
24 HIF_1_signaling_pathway_hsa04066 5 100 0.1105 0.2393
25 Tight_junction_hsa04530 7 170 0.1419 0.2951
26 Gap_junction_hsa04540 4 88 0.1844 0.3575
27 mTOR_signaling_pathway_hsa04150 6 151 0.1856 0.3575
28 Oocyte_meiosis_hsa04114 5 124 0.2069 0.3843
29 Jak_STAT_signaling_pathway_hsa04630 6 162 0.2293 0.4112
30 p53_signaling_pathway_hsa04115 3 68 0.248 0.4298
31 TNF_signaling_pathway_hsa04668 4 108 0.2933 0.492
32 Cell_adhesion_molecules_.CAMs._hsa04514 5 145 0.307 0.4988
33 ABC_transporters_hsa02010 2 45 0.3166 0.4988
34 Phosphatidylinositol_signaling_system_hsa04070 3 99 0.4606 0.7045
35 Mitophagy_animal_hsa04137 2 65 0.4933 0.7329
36 ErbB_signaling_pathway_hsa04012 2 85 0.6386 0.9027
37 Apoptosis_hsa04210 3 138 0.6834 0.9125
38 Wnt_signaling_pathway_hsa04310 3 146 0.7195 0.9125
39 Cellular_senescence_hsa04218 3 160 0.7749 0.9441
40 Neuroactive_ligand_receptor_interaction_hsa04080 5 278 0.8367 0.9888
41 Phagosome_hsa04145 2 152 0.9009 0.9996
42 Necroptosis_hsa04217 2 164 0.9227 0.9996

Quest ID: 0689ea28fd8c6c313eaf7fa0e25c9053