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This regulatory network was inferred from the input dataset. The miRNAs and mRNAs are presented as round and rectangle nodes respectively. The numerical value popped up upon mouse over the gene node is the log2 transformed fold-change of the gene expression between the two groups. All of the nodes are clickable, and the detailed information of the miRNAs/mRNAs and related cancer pathway will be displayed in another window. The edges between nodes are supported by both interactions (predicted or experimentally verified) and correlations learnt from cancer dataset. The numerical value popped up upon mouse over the edge is the correlation beat value (effect size) between the two nodes. The experimental evidences of the edges reported in previous cancer studies are highlighted by red/orange color. All of these information can be accessed by the "mouse-over" action. This network shows a full map of the miRNA-mRNA regulation of the input gene list(s), and the hub miRNAs (with the high network degree/betweenness centrality) would be the potential cancer drivers or tumor suppressors. The full result table can be accessed in the "Regulations" tab.

"miRNACancerMAP" is also a network visualization tool for users to draw their regulatory network by personal customization. Users can set the complexity of the network by limiting the number of nodes or edges. And the color of the nodes can be defined by different categories of the mRNAs and miRNAs, such as Gene-Ontology, pathway, and expression status. Users can also select to use network degree or network betweenness centrality to define the node size. And edges can be black or colored by the correlation. Purple edge means negative correlation (mostly found between miRNA and mRNA), and blue edge means positive correlation (found in PPI or miRNA-miRNA sponge effect). We can also add the protein-protein interactions (PPI) into the network. This result will show the cluster of genes regulated by some specific miRNAs. Additionally, miRNA-miRNA edges can be added by the "miRNA sponge" button, presenting some clusters of miRNAs that have the interactions via sponge effect.

miRNA-gene regulations

(Download full result)

Num microRNA           Gene miRNA log2FC miRNA pvalue Gene log2FC Gene pvalue Interaction Correlation beta Correlation P-value PMID Reported in cancer studies
1 hsa-miR-654-5p ACACB 0.2 0.03487 -0.69 0 MirTarget -0.4 0.00304 NA
2 hsa-miR-324-3p ACTN4 -0.15 0.01636 0.08 0.26115 miRNAWalker2 validate; PITA; miRNATAP -0.25 0.04571 NA
3 hsa-miR-654-5p ADAMTS17 0.2 0.03487 -0.01 0.84529 MirTarget -0.12 0.02029 NA
4 hsa-miR-324-3p ADCYAP1 -0.15 0.01636 -0.11 0.05017 PITA; miRNATAP -0.23 0.0175 NA
5 hsa-miR-665 AKAP13 0.29 0.01654 -0.46 0 miRNATAP -0.23 0.00218 NA
6 hsa-miR-324-3p ALDOA -0.15 0.01636 0.18 0.00366 miRNAWalker2 validate -0.24 0.03509 NA
7 hsa-miR-654-5p ANXA11 0.2 0.03487 -0.1 0.19622 MirTarget -0.19 0.04292 NA
8 hsa-miR-665 AP1G1 0.29 0.01654 -0.16 0.02465 PITA; miRNATAP -0.13 0.03849 NA
9 hsa-miR-324-3p APRT -0.15 0.01636 0.18 0.00143 miRNAWalker2 validate -0.26 0.00878 NA
10 hsa-miR-324-3p ARL8A -0.15 0.01636 0.29 0.00044 miRNATAP -0.31 0.03918 NA
11 hsa-miR-665 ARSB 0.29 0.01654 -0.19 0.00161 MirTarget -0.11 0.04251 NA
12 hsa-miR-665 B4GALT1 0.29 0.01654 -0.24 0.01167 mirMAP -0.19 0.03154 NA
13 hsa-miR-324-3p B4GALT2 -0.15 0.01636 0.22 8.0E-5 MirTarget -0.21 0.04483 NA
14 hsa-miR-654-5p BMP2 0.2 0.03487 -0.6 0 miRNATAP -0.3 0.02767 NA
15 hsa-miR-665 BNC2 0.29 0.01654 -0.57 0 PITA -0.18 0.02762 NA
16 hsa-miR-324-3p C1QTNF1 -0.15 0.01636 0.2 0.00052 MirTarget -0.23 0.02687 NA
17 hsa-miR-665 C3orf70 0.29 0.01654 -0.44 0 miRNATAP -0.16 0.04855 NA
18 hsa-miR-665 C5orf30 0.29 0.01654 -0.84 0 miRNATAP -0.47 0.0004 NA
19 hsa-miR-665 CA12 0.29 0.01654 -1.6 0 mirMAP -0.73 0.00203 NA
20 hsa-miR-654-5p CADM3 0.2 0.03487 -0.52 0 miRNATAP -0.3 0.00474 NA
21 hsa-miR-665 CAPN5 0.29 0.01654 -0.72 0 PITA; miRNATAP -0.25 0.03612 NA
22 hsa-miR-654-5p CEP170B 0.2 0.03487 -0.06 0.3019 MirTarget -0.15 0.02975 NA
23 hsa-miR-654-5p CGN 0.2 0.03487 -0.31 1.0E-5 MirTarget -0.2 0.02479 NA
24 hsa-miR-654-5p CIITA 0.2 0.03487 -0.24 0.00257 miRNATAP -0.25 0.01269 NA
25 hsa-miR-324-3p CIZ1 -0.15 0.01636 0.23 1.0E-5 miRNAWalker2 validate -0.22 0.02287 NA
26 hsa-miR-665 CLTB 0.29 0.01654 -0.45 0 miRNATAP -0.19 0.02805 NA
27 hsa-miR-602 CLYBL -0.02 0.79816 -0.12 0.0486 miRNATAP -0.24 0.00388 NA
28 hsa-miR-654-5p CNNM4 0.2 0.03487 -0.68 0 MirTarget -0.44 0.00138 NA
29 hsa-miR-665 CPNE8 0.29 0.01654 -1.16 0 miRNATAP -0.44 0.00854 NA
30 hsa-miR-665 CRIM1 0.29 0.01654 -0.14 0.1372 MirTarget; PITA; miRNATAP -0.18 0.04026 NA
31 hsa-miR-665 CRISPLD2 0.29 0.01654 -0.67 0 MirTarget -0.25 0.03986 NA
32 hsa-miR-665 CRYBG3 0.29 0.01654 -0.94 0 MirTarget -0.42 0.0037 NA
33 hsa-miR-654-5p CTDP1 0.2 0.03487 -0.06 0.11551 miRNATAP -0.12 0.00978 NA
34 hsa-miR-665 CTDSP2 0.29 0.01654 -0.2 0.00649 mirMAP -0.17 0.01309 NA
35 hsa-miR-665 DNAJC13 0.29 0.01654 -0.33 0.00192 MirTarget; PITA; miRNATAP -0.22 0.02417 NA
36 hsa-miR-665 ECE1 0.29 0.01654 -0.29 0.0001 mirMAP -0.18 0.00986 NA
37 hsa-miR-770-5p EDA2R -0.04 0.64438 -0.08 0.30296 MirTarget; PITA -0.26 0.0231 NA
38 hsa-miR-324-3p EEF2 -0.15 0.01636 0.23 0.00052 miRNAWalker2 validate -0.36 0.00316 NA
39 hsa-miR-665 EHF 0.29 0.01654 -0.33 0.10172 PITA -0.43 0.02061 NA
40 hsa-miR-770-5p EIF5A2 -0.04 0.64438 0.54 0 miRNATAP -0.34 0.02735 NA
41 hsa-miR-665 ELMO1 0.29 0.01654 -0.77 0 MirTarget -0.29 0.00666 NA
42 hsa-miR-324-3p FAM83H -0.15 0.01636 0.49 0 mirMAP -0.4 0.01522 NA
43 hsa-miR-665 FCRL5 0.29 0.01654 -0.27 0.0007 MirTarget -0.16 0.04234 NA
44 hsa-miR-665 FZD5 0.29 0.01654 -0.58 0 MirTarget; PITA; miRNATAP -0.29 0.01024 NA
45 hsa-miR-654-5p GALE 0.2 0.03487 0 0.97629 miRNATAP -0.24 0.00548 NA
46 hsa-miR-665 GDAP2 0.29 0.01654 -0.27 0.0053 MirTarget -0.23 0.01089 NA
47 hsa-miR-654-5p GDNF 0.2 0.03487 -0.08 0.17617 MirTarget -0.16 0.02402 NA
48 hsa-miR-324-3p GGA1 -0.15 0.01636 0 0.94933 miRNATAP -0.2 0.02979 NA
49 hsa-miR-665 GIMAP8 0.29 0.01654 -0.32 0 miRNATAP -0.13 0.0147 NA
50 hsa-miR-665 GLIPR2 0.29 0.01654 -0.91 0 MirTarget; miRNATAP -0.38 0.00292 NA
51 hsa-miR-654-5p GLP2R 0.2 0.03487 -0.67 0 miRNATAP -0.33 0.00624 NA
52 hsa-miR-665 GNG7 0.29 0.01654 -0.56 0 mirMAP -0.17 0.03129 NA
53 hsa-miR-665 GRAMD4 0.29 0.01654 -0.33 0 MirTarget -0.16 0.01668 NA
54 hsa-miR-654-5p GUCA2B 0.2 0.03487 -1.4 0 MirTarget -0.62 0.0081 NA
55 hsa-miR-665 HIPK1 0.29 0.01654 -0.17 0.01082 MirTarget; PITA -0.13 0.04695 NA
56 hsa-miR-324-3p HMGA1 -0.15 0.01636 0.45 0 miRNAWalker2 validate -0.57 0.00061 NA
57 hsa-miR-665 HSD11B2 0.29 0.01654 -1.36 0 miRNATAP -0.5 0.01008 NA
58 hsa-miR-324-3p IER5 -0.15 0.01636 0.07 0.17105 MirTarget -0.27 0.00168 NA
59 hsa-miR-665 IKZF3 0.29 0.01654 -0.71 0 MirTarget -0.35 0.00457 NA
60 hsa-miR-324-3p IMPDH2 -0.15 0.01636 0.44 0 miRNAWalker2 validate -0.43 0.01374 NA
61 hsa-miR-665 ISX 0.29 0.01654 -0.85 0 MirTarget -0.26 0.04603 NA
62 hsa-miR-665 KCNN3 0.29 0.01654 -0.4 0 MirTarget; PITA; miRNATAP -0.14 0.03834 NA
63 hsa-miR-654-5p KCNQ4 0.2 0.03487 0.03 0.56886 miRNATAP -0.14 0.02336 NA
64 hsa-miR-665 KDR 0.29 0.01654 -0.16 0.06671 PITA; miRNATAP -0.16 0.04801 NA
65 hsa-miR-324-3p KLF16 -0.15 0.01636 0.27 0.0002 mirMAP -0.34 0.01073 NA
66 hsa-miR-654-5p KRT8 0.2 0.03487 -0.16 0.0135 miRNATAP -0.22 0.00402 NA
67 hsa-miR-654-5p LCK 0.2 0.03487 -0.05 0.43327 MirTarget -0.16 0.02615 NA
68 hsa-miR-665 LDLRAP1 0.29 0.01654 -0.16 0.02944 MirTarget -0.2 0.00348 NA
69 hsa-miR-665 LITAF 0.29 0.01654 -0.24 0.00022 miRNATAP -0.17 0.00569 NA
70 hsa-miR-665 LMOD1 0.29 0.01654 -0.93 0 mirMAP -0.36 0.00592 NA
71 hsa-miR-665 LUZP1 0.29 0.01654 -0.31 1.0E-5 MirTarget; PITA; miRNATAP -0.19 0.00458 NA
72 hsa-miR-654-5p MALL 0.2 0.03487 -0.45 0 MirTarget -0.32 0.00535 NA
73 hsa-miR-665 MARCH8 0.29 0.01654 -0.61 0 mirMAP -0.27 0.00403 NA
74 hsa-miR-324-3p MED15 -0.15 0.01636 0.07 0.22923 miRNAWalker2 validate -0.22 0.04325 NA
75 hsa-miR-665 MED31 0.29 0.01654 -0.21 0.01037 MirTarget -0.17 0.02416 NA
76 hsa-miR-654-5p MGLL 0.2 0.03487 -0.53 0 MirTarget -0.29 0.02254 NA
77 hsa-miR-665 MTFR1L 0.29 0.01654 -0.29 0.00028 miRNATAP -0.17 0.02968 NA
78 hsa-miR-324-3p MYH9 -0.15 0.01636 0.02 0.84806 miRNAWalker2 validate -0.41 0.00715 NA
79 hsa-miR-665 NBL1 0.29 0.01654 -0.73 0 mirMAP -0.41 0.00859 NA
80 hsa-miR-324-3p NFIX -0.15 0.01636 0.13 0.08535 mirMAP -0.26 0.04393 NA
81 hsa-miR-654-5p NKX2-3 0.2 0.03487 -0.34 0 miRNATAP -0.2 0.00635 NA
82 hsa-miR-324-3p NSMF -0.15 0.01636 0.45 0 MirTarget; miRNATAP -0.35 0.02226 NA
83 hsa-miR-654-5p NTN1 0.2 0.03487 -0.2 3.0E-5 mirMAP -0.13 0.02828 NA
84 hsa-miR-654-5p NUDT8 0.2 0.03487 0.08 0.19109 PITA; miRNATAP -0.18 0.01581 NA
85 hsa-miR-324-3p PCYT2 -0.15 0.01636 0.05 0.23868 mirMAP -0.17 0.03329 NA
86 hsa-miR-654-5p PCYT2 0.2 0.03487 0.05 0.23868 MirTarget -0.16 0.00291 NA
87 hsa-miR-324-3p PDDC1 -0.15 0.01636 0.31 0 MirTarget -0.24 0.03418 NA
88 hsa-miR-654-5p PDZD3 0.2 0.03487 -0.47 0 miRNATAP -0.35 0.00146 NA
89 hsa-miR-654-5p PEX26 0.2 0.03487 -0.52 0 MirTarget -0.22 0.03605 NA
90 hsa-miR-665 PIM2 0.29 0.01654 -0.4 0.00256 miRNATAP -0.29 0.01996 NA
91 hsa-miR-654-5p PKP2 0.2 0.03487 -0.45 0.00259 MirTarget -0.5 0.00804 NA
92 hsa-miR-324-3p PKP3 -0.15 0.01636 0.19 0.00368 MirTarget; miRNATAP -0.27 0.02535 NA
93 hsa-miR-324-3p PLEKHA6 -0.15 0.01636 -0.12 0.09553 MirTarget -0.26 0.03769 NA
94 hsa-miR-654-5p PLEKHA6 0.2 0.03487 -0.12 0.09553 MirTarget -0.22 0.00761 NA
95 hsa-miR-324-3p PPP6R1 -0.15 0.01636 0.16 0.00266 miRNATAP -0.22 0.02119 NA
96 hsa-miR-324-3p PRKCSH -0.15 0.01636 0.2 0.00039 miRNAWalker2 validate -0.25 0.01308 NA
97 hsa-miR-665 PRR5L 0.29 0.01654 -0.56 0 MirTarget -0.26 0.01592 NA
98 hsa-miR-654-5p RAB11FIP1 0.2 0.03487 -0.02 0.84623 MirTarget -0.26 0.02584 NA
99 hsa-miR-324-3p RAD23A -0.15 0.01636 0.27 0 miRNAWalker2 validate -0.27 0.00905 NA
100 hsa-miR-324-3p RANGAP1 -0.15 0.01636 0.55 0 MirTarget -0.37 0.01895 NA
101 hsa-miR-324-3p RARG -0.15 0.01636 0.22 0.00069 MirTarget; PITA -0.3 0.01032 NA
102 hsa-miR-665 RBMS2 0.29 0.01654 -0.1 0.29659 miRNATAP -0.25 0.00397 NA
103 hsa-miR-324-3p RFX2 -0.15 0.01636 -0.02 0.68523 MirTarget -0.16 0.04273 NA
104 hsa-miR-665 RNF122 0.29 0.01654 -0.36 6.0E-5 MirTarget -0.19 0.03111 NA
105 hsa-miR-665 RNF135 0.29 0.01654 -0.2 0.01197 miRNATAP -0.18 0.01777 NA
106 hsa-miR-654-5p RNPEPL1 0.2 0.03487 0.03 0.62312 MirTarget -0.14 0.03288 NA
107 hsa-miR-324-3p RPLP1 -0.15 0.01636 0.12 0.11364 miRNAWalker2 validate -0.3 0.02706 NA
108 hsa-miR-665 RPS6KA3 0.29 0.01654 -0.24 0.07546 miRNATAP -0.25 0.04968 NA
109 hsa-miR-665 RPS6KA6 0.29 0.01654 -0.63 0.00026 MirTarget -0.33 0.0484 NA
110 hsa-miR-324-3p RUVBL2 -0.15 0.01636 0.36 0 miRNAWalker2 validate -0.31 0.00959 NA
111 hsa-miR-324-3p SETD1A -0.15 0.01636 0.08 0.10856 PITA; miRNATAP -0.16 0.04892 NA
112 hsa-miR-665 SIPA1L2 0.29 0.01654 -0.73 0 PITA -0.26 0.01948 NA
113 hsa-miR-665 SLAMF6 0.29 0.01654 -0.65 0.00027 miRNATAP -0.44 0.01044 NA
114 hsa-miR-654-5p SLC22A23 0.2 0.03487 -0.53 0 miRNATAP -0.39 9.0E-5 NA
115 hsa-miR-665 SLC22A23 0.29 0.01654 -0.53 0 mirMAP -0.17 0.02802 NA
116 hsa-miR-654-5p SLC25A34 0.2 0.03487 -0.26 0 MirTarget -0.17 0.01088 NA
117 hsa-miR-665 SLC31A2 0.29 0.01654 -0.36 0 MirTarget -0.14 0.04754 NA
118 hsa-miR-665 SLC41A2 0.29 0.01654 -1.02 0 MirTarget -0.53 0.00329 NA
119 hsa-miR-665 SLC51B 0.29 0.01654 -2.18 0 MirTarget -0.81 0.004 NA
120 hsa-miR-654-5p SLC6A8 0.2 0.03487 -0.09 0.25244 miRNATAP -0.2 0.03143 NA
121 hsa-miR-665 SMCHD1 0.29 0.01654 -0.78 0 miRNATAP -0.33 0.01758 NA
122 hsa-miR-654-5p SMPD3 0.2 0.03487 -0.72 0 MirTarget -0.44 0.00224 NA
123 hsa-miR-324-3p SMS -0.15 0.01636 0.24 0.00012 miRNAWalker2 validate -0.23 0.0442 NA
124 hsa-miR-665 SPRED1 0.29 0.01654 -0.23 0.02136 PITA; miRNATAP -0.25 0.00736 NA
125 hsa-miR-324-3p SPTBN2 -0.15 0.01636 0.41 0 miRNATAP -0.29 0.01825 NA
126 hsa-miR-665 SRSF4 0.29 0.01654 -0.17 0.00752 miRNATAP -0.15 0.00891 NA
127 hsa-miR-665 SSH2 0.29 0.01654 -0.29 0 miRNATAP -0.15 0.01678 NA
128 hsa-miR-665 STMN2 0.29 0.01654 -1.59 0 MirTarget -0.52 0.00947 NA
129 hsa-miR-665 SUSD6 0.29 0.01654 -0.34 0 MirTarget -0.14 0.04014 NA
130 hsa-miR-324-3p TAPBP -0.15 0.01636 0.07 0.32433 miRNAWalker2 validate -0.27 0.04551 NA
131 hsa-miR-324-3p TBL3 -0.15 0.01636 0.23 0 mirMAP -0.22 0.0168 NA
132 hsa-miR-665 TLE4 0.29 0.01654 -0.65 0 PITA -0.26 0.00474 NA
133 hsa-miR-654-5p TMEM125 0.2 0.03487 -0.19 0.0019 MirTarget -0.26 0.00035 NA
134 hsa-miR-654-5p TMEM189 0.2 0.03487 -0.08 0.17947 MirTarget -0.15 0.04164 NA
135 hsa-miR-324-3p TPPP -0.15 0.01636 0 0.99297 MirTarget -0.22 0.04515 NA
136 hsa-miR-654-5p TRABD 0.2 0.03487 0.05 0.34592 MirTarget -0.13 0.04706 NA
137 hsa-miR-324-3p TRIM65 -0.15 0.01636 0.16 0.00029 miRNAWalker2 validate -0.17 0.02514 NA
138 hsa-miR-324-3p TTLL12 -0.15 0.01636 0.32 6.0E-5 miRNAWalker2 validate -0.5 0.00062 NA
139 hsa-miR-665 UGDH 0.29 0.01654 -1.17 0 MirTarget -0.56 0.00211 NA
140 hsa-miR-665 USF3 0.29 0.01654 -0.41 0 MirTarget -0.27 0.00129 NA
141 hsa-miR-324-3p VARS -0.15 0.01636 0.52 0 miRNAWalker2 validate -0.42 0.00559 NA
142 hsa-miR-654-5p VDAC2 0.2 0.03487 -0.11 0.0337 miRNATAP -0.16 0.00823 NA
143 hsa-miR-665 VSIG4 0.29 0.01654 -0.69 8.0E-5 MirTarget -0.34 0.04385 NA
144 hsa-miR-324-3p WDR46 -0.15 0.01636 0.25 0 miRNAWalker2 validate -0.19 0.0271 NA
145 hsa-miR-654-5p WNK4 0.2 0.03487 -0.03 0.72545 miRNATAP -0.26 0.01359 NA
146 hsa-miR-324-3p WNT3A -0.15 0.01636 0.1 0.12263 MirTarget -0.26 0.025 NA
147 hsa-miR-665 ZCCHC2 0.29 0.01654 -0.25 0 MirTarget; PITA -0.11 0.01501 NA
148 hsa-miR-324-3p ZDHHC8 -0.15 0.01636 0.13 0.03009 MirTarget -0.22 0.04342 NA

Over-represented Gene Ontology Biological Process

NumGOOverlapSizeP ValueAdj. P Value
NumGOOverlapSizeP ValueAdj. P Value
NumGOOverlapSizeP ValueAdj. P Value

Over-represented Pathway

NumPathwayPathviewOverlapSizeP ValueAdj. P Value
1 Lysosome_hsa04142 5 123 0.002036 0.1059
2 mTOR_signaling_pathway_hsa04150 4 151 0.02433 0.6325
3 Hippo_signaling_pathway_hsa04390 3 154 0.1016 1
4 TGF_beta_signaling_pathway_hsa04350 2 84 0.1241 1
5 Tight_junction_hsa04530 3 170 0.1263 1
6 Regulation_of_actin_cytoskeleton_hsa04810 3 208 0.192 1
7 AMPK_signaling_pathway_hsa04152 2 121 0.2189 1
8 Oocyte_meiosis_hsa04114 2 124 0.2269 1
9 Endocytosis_hsa04144 3 244 0.2605 1
10 Signaling_pathways_regulating_pluripotency_of_stem_cells_hsa04550 2 139 0.2671 1
11 Wnt_signaling_pathway_hsa04310 2 146 0.2859 1
12 Cytokine_cytokine_receptor_interaction_hsa04060 3 270 0.3117 1
13 Cellular_senescence_hsa04218 2 160 0.3233 1
14 MAPK_signaling_pathway_hsa04010 3 295 0.3612 1
15 Focal_adhesion_hsa04510 2 199 0.4241 1
16 Rap1_signaling_pathway_hsa04015 2 206 0.4414 1
17 Ras_signaling_pathway_hsa04014 2 232 0.5032 1
18 PI3K_Akt_signaling_pathway_hsa04151 2 352 0.7271 1

Quest ID: 3851be9cfad75104929a07a43f576ab2