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This regulatory network was inferred from the input dataset. The miRNAs and mRNAs are presented as round and rectangle nodes respectively. The numerical value popped up upon mouse over the gene node is the log2 transformed fold-change of the gene expression between the two groups. All of the nodes are clickable, and the detailed information of the miRNAs/mRNAs and related cancer pathway will be displayed in another window. The edges between nodes are supported by both interactions (predicted or experimentally verified) and correlations learnt from cancer dataset. The numerical value popped up upon mouse over the edge is the correlation beat value (effect size) between the two nodes. The experimental evidences of the edges reported in previous cancer studies are highlighted by red/orange color. All of these information can be accessed by the "mouse-over" action. This network shows a full map of the miRNA-mRNA regulation of the input gene list(s), and the hub miRNAs (with the high network degree/betweenness centrality) would be the potential cancer drivers or tumor suppressors. The full result table can be accessed in the "Regulations" tab.

"miRNACancerMAP" is also a network visualization tool for users to draw their regulatory network by personal customization. Users can set the complexity of the network by limiting the number of nodes or edges. And the color of the nodes can be defined by different categories of the mRNAs and miRNAs, such as Gene-Ontology, pathway, and expression status. Users can also select to use network degree or network betweenness centrality to define the node size. And edges can be black or colored by the correlation. Purple edge means negative correlation (mostly found between miRNA and mRNA), and blue edge means positive correlation (found in PPI or miRNA-miRNA sponge effect). We can also add the protein-protein interactions (PPI) into the network. This result will show the cluster of genes regulated by some specific miRNAs. Additionally, miRNA-miRNA edges can be added by the "miRNA sponge" button, presenting some clusters of miRNAs that have the interactions via sponge effect.

miRNA-gene regulations

(Download full result)

Num microRNA           Gene miRNA log2FC miRNA pvalue Gene log2FC Gene pvalue Interaction Correlation beta Correlation P-value PMID Reported in cancer studies
1 hsa-miR-17-5p KAT2B 3.27 0 -1 2.0E-5 MirTarget; TargetScan -0.14 7.0E-5 23095762 miR 17 5p targets the p300/CBP associated factor and modulates androgen receptor transcriptional activity in cultured prostate cancer cells; Targeting of PCAF by miR-17-5p was evaluated using the luciferase reporter assay; Expression of PCAF in PCa cells was associated with the downregulation of miR-17-5p; Targeting of the 3'-untranslated region of PCAF mRNA by miR-17-5p caused translational suppression and RNA degradation and consequently modulation of AR transcriptional activity in PCa cells; PCAF is upregulated in cultured PCa cells and upregulation of PCAF is associated with the downregulation of miR-17-5p; Targeting of PCAF by miR-17-5p modulates AR transcriptional activity and cell growth in cultured PCa cells
2 hsa-miR-181a-5p KAT2B 2.3 0 -1 2.0E-5 miRNAWalker2 validate; miRTarBase; MirTarget -0.15 0.00154 NA
3 hsa-miR-181b-5p KAT2B 2.49 0 -1 2.0E-5 miRNAWalker2 validate; miRTarBase; MirTarget -0.12 0.00298 NA
4 hsa-miR-19a-3p KAT2B 3.42 0 -1 2.0E-5 miRNAWalker2 validate -0.15 1.0E-5 NA
5 hsa-miR-19b-3p KAT2B 2.5 0 -1 2.0E-5 miRNAWalker2 validate -0.16 0.00021 NA
6 hsa-miR-20a-3p KAT2B 2.93 0 -1 2.0E-5 MirTarget -0.1 0.00186 NA
7 hsa-miR-20a-5p KAT2B 3.16 0 -1 2.0E-5 MirTarget -0.15 5.0E-5 NA
8 hsa-miR-29a-5p KAT2B 1.47 0 -1 2.0E-5 MirTarget -0.27 0 NA
9 hsa-miR-576-5p KAT2B 2.2 0 -1 2.0E-5 mirMAP -0.13 0.00377 NA
10 hsa-miR-92a-3p KAT2B 2.06 0 -1 2.0E-5 miRNAWalker2 validate; MirTarget -0.18 0.00029 NA

Over-represented Gene Ontology Biological Process

NumGOOverlapSizeP ValueAdj. P Value
1 REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 82 1784 4.027e-29 1.874e-25
2 POSITIVE REGULATION OF GENE EXPRESSION 78 1733 6.068e-27 1.412e-23
3 POSITIVE REGULATION OF BIOSYNTHETIC PROCESS 75 1805 1.185e-23 1.837e-20
4 POSITIVE REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 53 1004 5.82e-21 6.77e-18
5 CELLULAR RESPONSE TO DNA DAMAGE STIMULUS 45 720 1.227e-20 1.142e-17
6 CHROMOSOME ORGANIZATION 51 1009 2.403e-19 1.863e-16
7 CELL CYCLE 58 1316 3.385e-19 2.25e-16
8 CELLULAR RESPONSE TO STRESS 63 1565 6.388e-19 3.716e-16
9 NEGATIVE REGULATION OF GENE EXPRESSION 61 1493 1.317e-18 6.811e-16
10 TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 42 724 4.309e-18 1.9e-15
11 CELL CYCLE PROCESS 51 1081 4.493e-18 1.9e-15
12 CHROMATIN ORGANIZATION 40 663 7.695e-18 2.984e-15
13 REGULATION OF CELL CYCLE 47 949 1.771e-17 6.338e-15
14 MITOTIC CELL CYCLE 42 766 3.286e-17 1.092e-14
15 REGULATION OF CELL DEATH 58 1472 6.149e-17 1.907e-14
16 NEGATIVE REGULATION OF NITROGEN COMPOUND METABOLIC PROCESS 57 1517 1.009e-15 2.933e-13
17 CHROMATIN MODIFICATION 33 539 5.157e-15 1.412e-12
18 INTERSPECIES INTERACTION BETWEEN ORGANISMS 36 662 1.013e-14 2.481e-12
19 SYMBIOSIS ENCOMPASSING MUTUALISM THROUGH PARASITISM 36 662 1.013e-14 2.481e-12
20 NEGATIVE REGULATION OF CELL DEATH 41 872 1.586e-14 3.691e-12
21 REGULATION OF BINDING 24 283 3.146e-14 6.971e-12
22 NEGATIVE REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 37 740 5.574e-14 1.179e-11
23 CELLULAR RESPONSE TO ORGANIC SUBSTANCE 60 1848 1.046e-13 2.117e-11
24 PEPTIDYL AMINO ACID MODIFICATION 39 841 1.18e-13 2.288e-11
25 REGULATION OF CELL PROLIFERATION 53 1496 1.404e-13 2.614e-11
26 REGULATION OF CELLULAR RESPONSE TO STRESS 35 691 1.993e-13 3.434e-11
27 REGULATION OF MITOTIC CELL CYCLE 29 468 1.964e-13 3.434e-11
28 DNA TEMPLATED TRANSCRIPTION ELONGATION 15 97 3.922e-13 6.518e-11
29 REGULATION OF CELL CYCLE PROCESS 31 558 4.939e-13 7.924e-11
30 TRANSCRIPTION ELONGATION FROM RNA POLYMERASE II PROMOTER 14 82 5.897e-13 9.146e-11
31 REGULATION OF PROTEIN MODIFICATION PROCESS 56 1710 6.211e-13 9.323e-11
32 NEGATIVE REGULATION OF CELL CYCLE 27 433 1.222e-12 1.777e-10
33 POSITIVE REGULATION OF CELLULAR COMPONENT ORGANIZATION 44 1152 2.077e-12 2.929e-10
34 COVALENT CHROMATIN MODIFICATION 24 345 2.344e-12 3.207e-10
35 DNA TEMPLATED TRANSCRIPTION INITIATION 19 202 2.668e-12 3.547e-10
36 DNA METABOLIC PROCESS 35 758 2.831e-12 3.659e-10
37 REGULATION OF CELL DIFFERENTIATION 50 1492 6.329e-12 7.749e-10
38 POSITIVE REGULATION OF PROTEIN METABOLIC PROCESS 50 1492 6.329e-12 7.749e-10
39 CELL CYCLE CHECKPOINT 18 194 1.288e-11 1.536e-09
40 PROTEIN PHOSPHORYLATION 38 944 1.813e-11 2.109e-09
41 TRANSCRIPTION INITIATION FROM RNA POLYMERASE II PROMOTER 16 153 3e-11 3.404e-09
42 RESPONSE TO ABIOTIC STIMULUS 39 1024 4.958e-11 5.493e-09
43 DNA REPAIR 26 480 7.508e-11 8.124e-09
44 NEGATIVE REGULATION OF CELL PROLIFERATION 30 643 9.28e-11 9.814e-09
45 RESPONSE TO ENDOGENOUS STIMULUS 47 1450 9.696e-11 1.003e-08
46 REGULATION OF RESPONSE TO STRESS 47 1468 1.467e-10 1.484e-08
47 NEGATIVE REGULATION OF MOLECULAR FUNCTION 39 1079 2.301e-10 2.229e-08
48 PHOSPHORYLATION 42 1228 2.297e-10 2.229e-08
49 REGULATION OF PROTEOLYSIS 31 711 2.347e-10 2.229e-08
50 REGULATION OF TRANSFERASE ACTIVITY 36 946 3.116e-10 2.9e-08
51 POSITIVE REGULATION OF CELL CYCLE 21 332 3.421e-10 3.122e-08
52 REGULATION OF CELL CYCLE ARREST 13 108 3.827e-10 3.425e-08
53 RESPONSE TO ORGANIC CYCLIC COMPOUND 35 917 5.249e-10 4.608e-08
54 POSITIVE REGULATION OF CELL CYCLE PROCESS 18 247 6.92e-10 5.963e-08
55 NOTCH SIGNALING PATHWAY 13 114 7.575e-10 6.409e-08
56 RESPONSE TO STEROID HORMONE 25 497 8.301e-10 6.897e-08
57 CELL DIVISION 24 460 8.944e-10 7.176e-08
58 RESPONSE TO LIPID 34 888 8.818e-10 7.176e-08
59 MACROMOLECULAR COMPLEX ASSEMBLY 44 1398 1.088e-09 8.582e-08
60 CELL CYCLE PHASE TRANSITION 18 255 1.155e-09 8.94e-08
61 POSITIVE REGULATION OF DEVELOPMENTAL PROCESS 39 1142 1.172e-09 8.94e-08
62 REGULATION OF CELL CYCLE PHASE TRANSITION 20 321 1.193e-09 8.953e-08
63 NEGATIVE REGULATION OF MITOTIC CELL CYCLE 16 199 1.524e-09 1.125e-07
64 PROTEIN DNA COMPLEX SUBUNIT ORGANIZATION 17 229 1.578e-09 1.147e-07
65 DNA INTEGRITY CHECKPOINT 14 146 1.68e-09 1.202e-07
66 CHROMATIN REMODELING 14 150 2.396e-09 1.689e-07
67 REGULATION OF ORGANELLE ORGANIZATION 39 1178 2.807e-09 1.95e-07
68 TISSUE MORPHOGENESIS 25 533 3.45e-09 2.361e-07
69 NEGATIVE REGULATION OF PROTEIN METABOLIC PROCESS 37 1087 3.638e-09 2.453e-07
70 SKELETAL SYSTEM DEVELOPMENT 23 455 3.736e-09 2.484e-07
71 TISSUE DEVELOPMENT 45 1518 4.39e-09 2.877e-07
72 REGULATION OF CHROMOSOME ORGANIZATION 18 278 4.55e-09 2.94e-07
73 PROTEIN COMPLEX SUBUNIT ORGANIZATION 45 1527 5.263e-09 3.355e-07
74 CELLULAR RESPONSE TO STEROID HORMONE STIMULUS 16 218 5.703e-09 3.586e-07
75 CELLULAR RESPONSE TO ENDOGENOUS STIMULUS 35 1008 6.155e-09 3.818e-07
76 REGULATION OF SIGNAL TRANSDUCTION BY P53 CLASS MEDIATOR 14 162 6.528e-09 3.997e-07
77 POSITIVE REGULATION OF DNA TEMPLATED TRANSCRIPTION INITIATION 7 24 7.554e-09 4.565e-07
78 MITOTIC NUCLEAR DIVISION 20 361 8.885e-09 5.233e-07
79 MITOTIC CELL CYCLE CHECKPOINT 13 139 8.815e-09 5.233e-07
80 MORPHOGENESIS OF AN EPITHELIUM 21 400 9.561e-09 5.561e-07
81 POSITIVE REGULATION OF MULTICELLULAR ORGANISMAL PROCESS 42 1395 1.02e-08 5.861e-07
82 REGULATION OF PROTEIN BINDING 14 168 1.044e-08 5.921e-07
83 POSITIVE REGULATION OF PROTEIN MODIFICATION PROCESS 37 1135 1.145e-08 6.417e-07
84 ORGANELLE FISSION 23 496 1.876e-08 1.039e-06
85 CELLULAR RESPONSE TO LIPID 22 457 2e-08 1.095e-06
86 CELL PROLIFERATION 27 672 2.089e-08 1.13e-06
87 DNA CONFORMATION CHANGE 17 273 2.205e-08 1.179e-06
88 POSITIVE REGULATION OF CELL PROLIFERATION 30 814 2.262e-08 1.196e-06
89 POSITIVE REGULATION OF TRANSCRIPTION INITIATION FROM RNA POLYMERASE II PROMOTER 6 17 2.54e-08 1.328e-06
90 REGULATION OF CHROMATIN ORGANIZATION 13 152 2.597e-08 1.343e-06
91 PEPTIDYL LYSINE MODIFICATION 18 312 2.729e-08 1.395e-06
92 POSITIVE REGULATION OF BINDING 12 127 2.967e-08 1.5e-06
93 NEGATIVE REGULATION OF CELL CYCLE PROCESS 15 214 3.202e-08 1.585e-06
94 REGULATION OF PROTEIN MODIFICATION BY SMALL PROTEIN CONJUGATION OR REMOVAL 17 280 3.198e-08 1.585e-06
95 REGULATION OF FIBROBLAST PROLIFERATION 10 81 3.323e-08 1.627e-06
96 PROTEIN LOCALIZATION TO ORGANELLE 24 556 3.54e-08 1.716e-06
97 ORGAN REGENERATION 10 83 4.217e-08 2.023e-06
98 REGULATION OF DNA TEMPLATED TRANSCRIPTION INITIATION 7 31 5.356e-08 2.517e-06
99 POSITIVE REGULATION OF CHROMATIN MODIFICATION 10 85 5.316e-08 2.517e-06
100 NEGATIVE REGULATION OF PROTEIN MODIFICATION PROCESS 25 616 5.973e-08 2.779e-06
101 CELL CYCLE G1 S PHASE TRANSITION 11 111 6.903e-08 3.149e-06
102 G1 S TRANSITION OF MITOTIC CELL CYCLE 11 111 6.903e-08 3.149e-06
103 NCRNA METABOLIC PROCESS 23 533 6.979e-08 3.153e-06
104 REGULATION OF MULTICELLULAR ORGANISMAL DEVELOPMENT 45 1672 7.911e-08 3.539e-06
105 RESPONSE TO RADIATION 20 413 8.247e-08 3.654e-06
106 REGULATION OF PHOSPHORUS METABOLIC PROCESS 44 1618 8.471e-08 3.718e-06
107 VIRAL LATENCY 5 11 8.781e-08 3.819e-06
108 POSITIVE REGULATION OF CELL DIFFERENTIATION 29 823 1.035e-07 4.46e-06
109 REGULATION OF CATABOLIC PROCESS 27 731 1.162e-07 4.96e-06
110 PROTEASOMAL PROTEIN CATABOLIC PROCESS 16 271 1.206e-07 5.103e-06
111 CELLULAR RESPONSE TO ORGANIC CYCLIC COMPOUND 21 465 1.253e-07 5.254e-06
112 REGULATION OF RESPONSE TO DNA DAMAGE STIMULUS 12 145 1.298e-07 5.391e-06
113 POSITIVE REGULATION OF FIBROBLAST PROLIFERATION 8 53 1.643e-07 6.765e-06
114 EPITHELIUM DEVELOPMENT 31 945 1.771e-07 7.165e-06
115 EMBRYO DEVELOPMENT 30 894 1.76e-07 7.165e-06
116 RESPONSE TO GROWTH FACTOR 21 475 1.786e-07 7.165e-06
117 POSITIVE REGULATION OF CHROMOSOME ORGANIZATION 12 150 1.882e-07 7.485e-06
118 RNA CAPPING 7 37 1.977e-07 7.601e-06
119 X7 METHYLGUANOSINE RNA CAPPING 7 37 1.977e-07 7.601e-06
120 GLAND DEVELOPMENT 19 395 1.953e-07 7.601e-06
121 REGULATION OF TRANSCRIPTION INITIATION FROM RNA POLYMERASE II PROMOTER 6 23 1.955e-07 7.601e-06
122 POSITIVE REGULATION OF MOLECULAR FUNCTION 46 1791 2.164e-07 8.228e-06
123 REGULATION OF MUSCLE CELL DIFFERENTIATION 12 152 2.175e-07 8.228e-06
124 MITOTIC DNA INTEGRITY CHECKPOINT 10 100 2.527e-07 9.482e-06
125 ANAPHASE PROMOTING COMPLEX DEPENDENT CATABOLIC PROCESS 9 77 2.648e-07 9.795e-06
126 POSITIVE REGULATION OF PROTEOLYSIS 18 363 2.652e-07 9.795e-06
127 POSITIVE REGULATION OF RESPONSE TO STIMULUS 48 1929 2.848e-07 1.043e-05
128 POSITIVE REGULATION OF VIRAL TRANSCRIPTION 7 39 2.895e-07 1.052e-05
129 POSTTRANSCRIPTIONAL REGULATION OF GENE EXPRESSION 20 448 3.043e-07 1.098e-05
130 NEGATIVE REGULATION OF BINDING 11 131 3.777e-07 1.342e-05
131 BRANCHING MORPHOGENESIS OF AN EPITHELIAL TUBE 11 131 3.777e-07 1.342e-05
132 NEGATIVE REGULATION OF RESPONSE TO STIMULUS 38 1360 3.857e-07 1.36e-05
133 SNRNA METABOLIC PROCESS 9 82 4.575e-07 1.601e-05
134 CELLULAR RESPONSE TO ABIOTIC STIMULUS 15 263 4.701e-07 1.633e-05
135 AGING 15 264 4.934e-07 1.701e-05
136 REGULATION OF VIRAL TRANSCRIPTION 8 61 5.04e-07 1.724e-05
137 REGULATION OF DNA METABOLIC PROCESS 17 340 5.129e-07 1.742e-05
138 POSITIVE REGULATION OF PROTEIN COMPLEX ASSEMBLY 13 197 5.403e-07 1.822e-05
139 ORGAN MORPHOGENESIS 28 841 5.499e-07 1.841e-05
140 EMBRYO DEVELOPMENT ENDING IN BIRTH OR EGG HATCHING 22 554 5.612e-07 1.865e-05
141 PHOSPHATE CONTAINING COMPOUND METABOLIC PROCESS 48 1977 5.85e-07 1.931e-05
142 POSITIVE REGULATION OF LIGASE ACTIVITY 10 110 6.188e-07 2.028e-05
143 POSITIVE REGULATION OF CELL CYCLE ARREST 9 85 6.238e-07 2.03e-05
144 INTRACELLULAR RECEPTOR SIGNALING PATHWAY 12 168 6.415e-07 2.073e-05
145 REGULATION OF CELL DIVISION 15 272 7.201e-07 2.311e-05
146 RESPONSE TO DRUG 19 431 7.355e-07 2.344e-05
147 IN UTERO EMBRYONIC DEVELOPMENT 16 311 7.69e-07 2.434e-05
148 REGULATION OF CELLULAR PROTEIN CATABOLIC PROCESS 15 274 7.898e-07 2.483e-05
149 REGULATION OF PROTEIN CATABOLIC PROCESS 18 393 8.42e-07 2.63e-05
150 REGULATION OF ORGAN MORPHOGENESIS 14 242 9.648e-07 2.993e-05
151 POSITIVE REGULATION OF ORGANELLE ORGANIZATION 22 573 9.84e-07 3.013e-05
152 PROTEIN COMPLEX BIOGENESIS 33 1132 9.907e-07 3.013e-05
153 PROTEIN COMPLEX ASSEMBLY 33 1132 9.907e-07 3.013e-05
154 RESPONSE TO IONIZING RADIATION 11 145 1.045e-06 3.157e-05
155 CHROMATIN ASSEMBLY OR DISASSEMBLY 12 177 1.118e-06 3.337e-05
156 NEGATIVE REGULATION OF CELL CYCLE PHASE TRANSITION 11 146 1.119e-06 3.337e-05
157 MACROMOLECULE CATABOLIC PROCESS 29 926 1.175e-06 3.475e-05
158 POSITIVE REGULATION OF CELL CYCLE PHASE TRANSITION 8 68 1.18e-06 3.475e-05
159 CARTILAGE DEVELOPMENT 11 147 1.197e-06 3.503e-05
160 CELL DEVELOPMENT 38 1426 1.233e-06 3.586e-05
161 REGULATION OF KINASE ACTIVITY 26 776 1.283e-06 3.707e-05
162 REGULATION OF EPITHELIAL CELL PROLIFERATION 15 285 1.293e-06 3.715e-05
163 CELLULAR MACROMOLECULAR COMPLEX ASSEMBLY 25 727 1.307e-06 3.732e-05
164 REGULATION OF PROTEASOMAL PROTEIN CATABOLIC PROCESS 12 181 1.416e-06 4.017e-05
165 RESPONSE TO OXYGEN CONTAINING COMPOUND 37 1381 1.533e-06 4.322e-05
166 REGULATION OF CELL DEVELOPMENT 27 836 1.59e-06 4.457e-05
167 INTRACELLULAR STEROID HORMONE RECEPTOR SIGNALING PATHWAY 8 71 1.648e-06 4.593e-05
168 RESPONSE TO GAMMA RADIATION 7 50 1.687e-06 4.673e-05
169 RESPONSE TO HORMONE 28 893 1.785e-06 4.913e-05
170 CELLULAR SENESCENCE 6 33 1.946e-06 5.327e-05
171 STEROID HORMONE MEDIATED SIGNALING PATHWAY 10 125 2.012e-06 5.473e-05
172 G1 DNA DAMAGE CHECKPOINT 8 73 2.042e-06 5.523e-05
173 POSITIVE REGULATION OF CELL DEATH 22 605 2.396e-06 6.444e-05
174 PROTEIN ACYLATION 11 159 2.588e-06 6.922e-05
175 PROTEIN ACETYLATION 10 129 2.679e-06 7.041e-05
176 CELL FATE COMMITMENT 13 227 2.653e-06 7.041e-05
177 NEGATIVE REGULATION OF CELL DIFFERENTIATION 22 609 2.665e-06 7.041e-05
178 REGULATION OF CYTOKINE PRODUCTION 21 563 2.764e-06 7.226e-05
179 TRANSCRIPTION FROM RNA POLYMERASE I PROMOTER 6 35 2.798e-06 7.272e-05
180 REGULATION OF LIGASE ACTIVITY 10 130 2.873e-06 7.426e-05
181 REGENERATION 11 161 2.923e-06 7.438e-05
182 CONNECTIVE TISSUE DEVELOPMENT 12 194 2.925e-06 7.438e-05
183 DNA PACKAGING 12 194 2.925e-06 7.438e-05
184 NEGATIVE REGULATION OF CELL COMMUNICATION 33 1192 3.038e-06 7.682e-05
185 POSITIVE REGULATION OF TRANSFERASE ACTIVITY 22 616 3.204e-06 8.059e-05
186 NEGATIVE REGULATION OF MUSCLE CELL DIFFERENTIATION 7 55 3.263e-06 8.119e-05
187 POSITIVE REGULATION OF PROTEIN MODIFICATION BY SMALL PROTEIN CONJUGATION OR REMOVAL 12 196 3.253e-06 8.119e-05
188 REGULATION OF CELLULAR COMPONENT BIOGENESIS 25 767 3.388e-06 8.385e-05
189 NEGATIVE REGULATION OF MULTICELLULAR ORGANISMAL PROCESS 29 983 3.818e-06 9.399e-05
190 REGULATION OF CELLULAR AMIDE METABOLIC PROCESS 16 354 4.127e-06 0.0001011
191 MORPHOGENESIS OF A BRANCHING STRUCTURE 11 167 4.167e-06 0.0001015
192 CELLULAR RESPONSE TO RADIATION 10 137 4.607e-06 0.0001117
193 REGULATION OF GROWTH 22 633 4.951e-06 0.0001194
194 CELL DEATH 29 1001 5.42e-06 0.00013
195 RESPONSE TO ALCOHOL 16 362 5.479e-06 0.0001307
196 POSITIVE REGULATION OF CELL COMMUNICATION 38 1532 6.691e-06 0.0001589
197 NEGATIVE REGULATION OF DEVELOPMENTAL PROCESS 25 801 7.199e-06 0.00017
198 REGULATION OF CYSTEINE TYPE ENDOPEPTIDASE ACTIVITY 12 213 7.637e-06 0.0001795
199 POSITIVE REGULATION OF DNA BINDING 6 42 8.449e-06 0.0001966
200 NCRNA TRANSCRIPTION 8 88 8.41e-06 0.0001966
201 REGULATION OF CELL CYCLE G1 S PHASE TRANSITION 10 147 8.626e-06 0.0001997
202 CELLULAR RESPONSE TO EPIDERMAL GROWTH FACTOR STIMULUS 5 25 8.843e-06 0.0002037
203 MAMMARY GLAND DEVELOPMENT 9 117 9.077e-06 0.0002081
204 PEPTIDYL SERINE MODIFICATION 10 148 9.158e-06 0.0002089
205 REGULATION OF PROTEIN LOCALIZATION TO NUCLEUS 12 218 9.66e-06 0.0002193
206 CELLULAR RESPONSE TO UV 7 66 1.124e-05 0.0002539
207 REGULATION OF RNA POLYMERASE II TRANSCRIPTIONAL PREINITIATION COMPLEX ASSEMBLY 4 13 1.162e-05 0.0002599
208 REGULATION OF HISTONE PHOSPHORYLATION 4 13 1.162e-05 0.0002599
209 POSITIVE REGULATION OF VIRAL PROCESS 8 92 1.17e-05 0.0002606
210 CELL AGING 7 67 1.243e-05 0.0002753
211 REGULATION OF DNA BINDING 8 93 1.268e-05 0.0002796
212 MUSCLE STRUCTURE DEVELOPMENT 17 432 1.279e-05 0.0002808
213 POSITIVE REGULATION OF PROTEIN CATABOLIC PROCESS 13 263 1.308e-05 0.0002857
214 POSITIVE REGULATION OF MITOTIC CELL CYCLE 9 123 1.362e-05 0.0002961
215 RNA PROCESSING 25 835 1.46e-05 0.0003159
216 PROTEIN CATABOLIC PROCESS 20 579 1.483e-05 0.0003166
217 CANONICAL WNT SIGNALING PATHWAY 8 95 1.483e-05 0.0003166
218 REGULATION OF PEPTIDASE ACTIVITY 16 392 1.479e-05 0.0003166
219 POSITIVE REGULATION OF CELLULAR PROTEIN CATABOLIC PROCESS 11 192 1.569e-05 0.0003334
220 HORMONE MEDIATED SIGNALING PATHWAY 10 158 1.624e-05 0.0003436
221 REGULATION OF INTRACELLULAR SIGNAL TRANSDUCTION 39 1656 1.651e-05 0.0003466
222 RESPONSE TO UV 9 126 1.654e-05 0.0003466
223 POSITIVE REGULATION OF PROTEASOMAL PROTEIN CATABOLIC PROCESS 8 98 1.864e-05 0.0003872
224 NEGATIVE REGULATION OF CELL CYCLE G1 S PHASE TRANSITION 8 98 1.864e-05 0.0003872
225 REGULATION OF NUCLEAR DIVISION 10 163 2.129e-05 0.0004402
226 RESPONSE TO EPIDERMAL GROWTH FACTOR 5 30 2.262e-05 0.0004656
227 POSITIVE REGULATION OF CELLULAR COMPONENT BIOGENESIS 16 406 2.271e-05 0.0004656
228 HISTONE H4 ACETYLATION 6 50 2.369e-05 0.0004834
229 REGULATION OF APOPTOTIC SIGNALING PATHWAY 15 363 2.381e-05 0.0004838
230 TUBE DEVELOPMENT 19 552 2.562e-05 0.0005183
231 TUBE MORPHOGENESIS 14 323 2.649e-05 0.0005336
232 REGULATION OF PROTEIN UBIQUITINATION INVOLVED IN UBIQUITIN DEPENDENT PROTEIN CATABOLIC PROCESS 8 103 2.68e-05 0.0005376
233 RESPONSE TO EXTERNAL STIMULUS 41 1821 2.776e-05 0.0005543
234 REGULATION OF SYMBIOSIS ENCOMPASSING MUTUALISM THROUGH PARASITISM 11 205 2.883e-05 0.0005707
235 APOPTOTIC PROCESS INVOLVED IN MORPHOGENESIS 4 16 2.878e-05 0.0005707
236 NUCLEUS ORGANIZATION 9 136 3.041e-05 0.0005997
237 REGULATION OF FAT CELL DIFFERENTIATION 8 106 3.3e-05 0.0006452
238 DNA REPLICATION 11 208 3.294e-05 0.0006452
239 MAMMARY GLAND EPITHELIUM DEVELOPMENT 6 53 3.325e-05 0.0006472
240 REGULATION OF PROTEIN COMPLEX ASSEMBLY 15 375 3.463e-05 0.0006687
241 REGULATION OF CELLULAR COMPONENT MOVEMENT 23 771 3.459e-05 0.0006687
242 NEGATIVE REGULATION OF PROTEIN MODIFICATION BY SMALL PROTEIN CONJUGATION OR REMOVAL 9 139 3.613e-05 0.0006933
243 NEGATIVE REGULATION OF PHOSPHORYLATION 16 422 3.621e-05 0.0006933
244 NEGATIVE REGULATION OF PROTEIN BINDING 7 79 3.682e-05 0.0007021
245 NEGATIVE REGULATION OF CATALYTIC ACTIVITY 24 829 3.742e-05 0.0007108
246 POSITIVE REGULATION OF CELL DEVELOPMENT 17 472 3.933e-05 0.000744
247 CELLULAR MACROMOLECULE LOCALIZATION 31 1234 4.13e-05 0.000778
248 DNA GEOMETRIC CHANGE 7 81 4.331e-05 0.0008126
249 CYTOSKELETON ORGANIZATION 24 838 4.439e-05 0.0008294
250 REGULATION OF PROTEIN LOCALIZATION 26 950 4.509e-05 0.0008393
251 EPITHELIAL TO MESENCHYMAL TRANSITION 6 56 4.568e-05 0.0008467
252 POSITIVE REGULATION OF CELLULAR AMIDE METABOLIC PROCESS 8 111 4.598e-05 0.0008489
253 NEGATIVE REGULATION OF ORGANELLE ORGANIZATION 15 387 4.958e-05 0.0009119
254 REGULATION OF INTRINSIC APOPTOTIC SIGNALING PATHWAY 9 145 5.034e-05 0.0009221
255 IMMUNE SYSTEM DEVELOPMENT 19 582 5.234e-05 0.0009514
256 NUCLEOTIDE EXCISION REPAIR 8 113 5.224e-05 0.0009514
257 REGULATION OF NUCLEOCYTOPLASMIC TRANSPORT 11 220 5.489e-05 0.0009938
258 ENZYME LINKED RECEPTOR PROTEIN SIGNALING PATHWAY 21 689 5.662e-05 0.001013
259 REGULATION OF ERYTHROCYTE DIFFERENTIATION 5 36 5.656e-05 0.001013
260 POSITIVE REGULATION OF PROTEIN ACETYLATION 5 36 5.656e-05 0.001013
261 REGULATION OF PROTEIN IMPORT 10 183 5.714e-05 0.001018
262 REGULATION OF ANATOMICAL STRUCTURE MORPHOGENESIS 27 1021 5.733e-05 0.001018
263 REGULATION OF PROTEASOMAL UBIQUITIN DEPENDENT PROTEIN CATABOLIC PROCESS 9 148 5.905e-05 0.001045
264 MICROTUBULE CYTOSKELETON ORGANIZATION 14 348 5.952e-05 0.001047
265 LIVER REGENERATION 4 19 5.964e-05 0.001047
266 REGULATION OF CELL CYCLE G2 M PHASE TRANSITION 6 59 6.158e-05 0.001077
267 EMBRYONIC MORPHOGENESIS 18 539 6.198e-05 0.00108
268 POSITIVE REGULATION OF CATABOLIC PROCESS 15 395 6.246e-05 0.001084
269 INTRACELLULAR SIGNAL TRANSDUCTION 36 1572 6.532e-05 0.00113
270 RNA SPLICING VIA TRANSESTERIFICATION REACTIONS 12 267 7.089e-05 0.001222
271 REGULATION OF HOMEOSTATIC PROCESS 16 447 7.157e-05 0.001229
272 REGULATION OF WNT SIGNALING PATHWAY 13 310 7.199e-05 0.001232
273 NUCLEAR TRANSPORT 14 355 7.363e-05 0.00125
274 REGULATION OF STEM CELL PROLIFERATION 7 88 7.383e-05 0.00125
275 MESENCHYME MORPHOGENESIS 5 38 7.389e-05 0.00125
276 CELL CYCLE ARREST 9 154 8.031e-05 0.001349
277 POSITIVE REGULATION OF EPITHELIAL CELL PROLIFERATION 9 154 8.031e-05 0.001349
278 NEUROGENESIS 33 1402 8.127e-05 0.00136
279 DEVELOPMENTAL PROCESS INVOLVED IN REPRODUCTION 19 602 8.184e-05 0.001365
280 PROTEIN MODIFICATION BY SMALL PROTEIN CONJUGATION OR REMOVAL 24 873 8.39e-05 0.001384
281 CELLULAR RESPONSE TO HORMONE STIMULUS 18 552 8.388e-05 0.001384
282 REGULATION OF CELLULAR PROTEIN LOCALIZATION 18 552 8.388e-05 0.001384
283 EMBRYONIC ORGAN DEVELOPMENT 15 406 8.491e-05 0.001396
284 ESTABLISHMENT OF PROTEIN LOCALIZATION TO ORGANELLE 14 361 8.796e-05 0.001441
285 PROTEIN LOCALIZATION TO NUCLEUS 9 156 8.869e-05 0.001448
286 APOPTOTIC PROCESS INVOLVED IN DEVELOPMENT 4 21 9.042e-05 0.001471
287 CELLULAR RESPONSE TO LIGHT STIMULUS 7 91 9.14e-05 0.001482
288 RESPONSE TO ENDOPLASMIC RETICULUM STRESS 11 233 9.183e-05 0.001484
289 ANTERIOR POSTERIOR PATTERN SPECIFICATION 10 194 9.305e-05 0.001498
290 MUSCLE TISSUE DEVELOPMENT 12 275 9.385e-05 0.001501
291 RESPONSE TO CYTOKINE 21 714 9.364e-05 0.001501
292 ENDOCRINE SYSTEM DEVELOPMENT 8 123 9.522e-05 0.001517
293 EAR DEVELOPMENT 10 195 9.71e-05 0.001542
294 REGULATION OF PROTEIN ACETYLATION 6 64 9.764e-05 0.001545
295 MRNA METABOLIC PROCESS 19 611 9.936e-05 0.001567
296 REGULATION OF CANONICAL WNT SIGNALING PATHWAY 11 236 0.0001029 0.001617
297 MUSCLE CELL DIFFERENTIATION 11 237 0.0001068 0.001673
298 ENDOCARDIAL CUSHION MORPHOGENESIS 4 22 0.0001095 0.00171
299 RESPONSE TO LIGHT STIMULUS 12 280 0.0001112 0.001731
300 CELLULAR COMPONENT DISASSEMBLY 17 515 0.0001143 0.001773
301 PATTERN SPECIFICATION PROCESS 15 418 0.0001172 0.001811
302 SIGNAL TRANSDUCTION BY P53 CLASS MEDIATOR 8 127 0.0001191 0.001835
303 HEPATICOBILIARY SYSTEM DEVELOPMENT 8 128 0.0001258 0.001932
304 SIGNAL TRANSDUCTION IN RESPONSE TO DNA DAMAGE 7 96 0.0001282 0.001962
305 SINGLE ORGANISM CELLULAR LOCALIZATION 24 898 0.000129 0.001968
306 NEGATIVE REGULATION OF PROTEOLYSIS 13 329 0.0001305 0.001985
307 REGULATION OF NUCLEASE ACTIVITY 4 23 0.0001314 0.001991
308 REGULATION OF MICROTUBULE BASED PROCESS 11 243 0.0001331 0.002011
309 MICROTUBULE BASED PROCESS 17 522 0.0001343 0.002011
310 PROTEIN LOCALIZATION TO MEMBRANE 14 376 0.0001349 0.002011
311 CARDIOVASCULAR SYSTEM DEVELOPMENT 22 788 0.0001347 0.002011
312 CIRCULATORY SYSTEM DEVELOPMENT 22 788 0.0001347 0.002011
313 GLAND MORPHOGENESIS 7 97 0.0001368 0.002027
314 REGULATION OF CYCLIN DEPENDENT PROTEIN KINASE ACTIVITY 7 97 0.0001368 0.002027
315 MITOTIC SPINDLE ORGANIZATION 6 69 0.0001488 0.002198
316 REGULATION OF DNA TEMPLATED TRANSCRIPTION ELONGATION 5 44 0.0001511 0.002225
317 RESPONSE TO VIRUS 11 247 0.0001536 0.002254
318 DNA DEPENDENT DNA REPLICATION 7 99 0.0001555 0.002275
319 REGULATION OF TRANSCRIPTION ELONGATION FROM RNA POLYMERASE II PROMOTER 4 24 0.0001562 0.002279
320 RESPONSE TO INORGANIC SUBSTANCE 16 479 0.0001589 0.00231
321 PROTEOLYSIS 29 1208 0.0001636 0.002371
322 DNA TEMPLATED TRANSCRIPTION TERMINATION 7 101 0.0001761 0.002545
323 HOMEOSTATIC PROCESS 31 1337 0.0001783 0.002568
324 HISTONE PHOSPHORYLATION 4 25 0.0001843 0.002646
325 IMMUNE SYSTEM PROCESS 41 1984 0.0001861 0.002664
326 NEGATIVE REGULATION OF INTRACELLULAR SIGNAL TRANSDUCTION 15 437 0.0001901 0.002714
327 HEART MORPHOGENESIS 10 212 0.0001925 0.002739
328 REGULATION OF MUSCLE TISSUE DEVELOPMENT 7 103 0.000199 0.002814
329 REGULATION OF MUSCLE ORGAN DEVELOPMENT 7 103 0.000199 0.002814
330 TRANSCRIPTION COUPLED NUCLEOTIDE EXCISION REPAIR 6 73 0.0002033 0.002864
331 NEGATIVE REGULATION OF PHOSPHORUS METABOLIC PROCESS 17 541 0.000205 0.002864
332 RIBONUCLEOPROTEIN COMPLEX BIOGENESIS 15 440 0.0002047 0.002864
333 NEGATIVE REGULATION OF PHOSPHATE METABOLIC PROCESS 17 541 0.000205 0.002864
334 CELL CYCLE G2 M PHASE TRANSITION 8 138 0.0002115 0.002946
335 GAMETE GENERATION 18 595 0.0002127 0.002954
336 DEVELOPMENTAL PROGRAMMED CELL DEATH 4 26 0.0002158 0.002962
337 REGULATION OF CELLULAR SENESCENCE 4 26 0.0002158 0.002962
338 NEGATIVE REGULATION OF STRIATED MUSCLE CELL DIFFERENTIATION 4 26 0.0002158 0.002962
339 DNA RECOMBINATION 10 215 0.0002156 0.002962
340 CENTRAL NERVOUS SYSTEM DEVELOPMENT 23 872 0.0002166 0.002964
341 ATP DEPENDENT CHROMATIN REMODELING 6 74 0.0002191 0.00299
342 SENSORY ORGAN DEVELOPMENT 16 493 0.0002199 0.002992
343 RESPONSE TO CORTICOSTEROID 9 176 0.0002211 0.002999
344 REGULATION OF CARDIAC MUSCLE TISSUE DEVELOPMENT 5 48 0.0002294 0.003103
345 REGULATION OF PROTEIN COMPLEX DISASSEMBLY 10 217 0.0002323 0.003133
346 REGULATION OF DNA REPAIR 6 75 0.0002359 0.003172
347 EPITHELIAL TO MESENCHYMAL TRANSITION INVOLVED IN ENDOCARDIAL CUSHION FORMATION 3 11 0.0002373 0.003183
348 REGULATION OF MICROTUBULE POLYMERIZATION OR DEPOLYMERIZATION 9 178 0.0002405 0.003215
349 WNT SIGNALING PATHWAY 13 351 0.0002459 0.003269
350 NEGATIVE REGULATION OF TRANSFERASE ACTIVITY 13 351 0.0002459 0.003269
351 NEGATIVE REGULATION OF INTRINSIC APOPTOTIC SIGNALING PATHWAY IN RESPONSE TO DNA DAMAGE 4 27 0.0002511 0.003309
352 REGULATION OF CATENIN IMPORT INTO NUCLEUS 4 27 0.0002511 0.003309
353 NEGATIVE REGULATION OF SIGNAL TRANSDUCTION BY P53 CLASS MEDIATOR 4 27 0.0002511 0.003309
354 REGULATION OF PROTEIN TARGETING 12 307 0.0002609 0.003429
355 CELLULAR RESPONSE TO CYTOKINE STIMULUS 18 606 0.0002655 0.00348
356 REGULATION OF SODIUM ION TRANSPORT 6 77 0.0002724 0.003559
357 ESTABLISHMENT OF PROTEIN LOCALIZATION TO MEMBRANE 11 264 0.0002731 0.003559
358 POSITIVE REGULATION OF STEM CELL DIFFERENTIATION 5 50 0.0002786 0.003621
359 REGULATION OF DNA DAMAGE RESPONSE SIGNAL TRANSDUCTION BY P53 CLASS MEDIATOR 4 28 0.0002902 0.003762
360 POSITIVE REGULATION OF GENE EXPRESSION EPIGENETIC 6 78 0.0002923 0.003762
361 RESPONSE TO OXYGEN LEVELS 12 311 0.0002935 0.003762
362 SOMITE DEVELOPMENT 6 78 0.0002923 0.003762
363 REGIONALIZATION 12 311 0.0002935 0.003762
364 REGULATION OF MYELOID CELL DIFFERENTIATION 9 183 0.0002953 0.003774
365 CARTILAGE MORPHOGENESIS 3 12 0.0003137 0.003978
366 REGULATION OF VITAMIN METABOLIC PROCESS 3 12 0.0003137 0.003978
367 BONE MORPHOGENESIS 6 79 0.0003133 0.003978
368 REGULATION OF TYPE I INTERFERON PRODUCTION 7 111 0.0003154 0.003988
369 POSITIVE REGULATION OF DNA METABOLIC PROCESS 9 185 0.0003199 0.004034
370 ANATOMICAL STRUCTURE FORMATION INVOLVED IN MORPHOGENESIS 24 957 0.0003307 0.004159
371 REGULATION OF HEART MORPHOGENESIS 4 29 0.0003336 0.004184
372 NEGATIVE REGULATION OF RESPONSE TO DNA DAMAGE STIMULUS 5 52 0.0003354 0.004195
373 REGULATION OF STEM CELL DIFFERENTIATION 7 113 0.0003517 0.004388
374 REGULATION OF GENE EXPRESSION EPIGENETIC 10 229 0.0003568 0.004439
375 REGULATION OF SEQUENCE SPECIFIC DNA BINDING TRANSCRIPTION FACTOR ACTIVITY 13 365 0.0003578 0.004439
376 REGULATION OF EMBRYONIC DEVELOPMENT 7 114 0.0003711 0.004593
377 HEART DEVELOPMENT 15 466 0.0003765 0.004647
378 MESENCHYME DEVELOPMENT 9 190 0.000389 0.004788
379 ESTABLISHMENT OR MAINTENANCE OF TRANSMEMBRANE ELECTROCHEMICAL GRADIENT 3 13 0.0004044 0.004913
380 WHITE FAT CELL DIFFERENTIATION 3 13 0.0004044 0.004913
381 REGULATION OF IRE1 MEDIATED UNFOLDED PROTEIN RESPONSE 3 13 0.0004044 0.004913
382 RESPONSE TO NUTRIENT 9 191 0.0004041 0.004913
383 NEGATIVE REGULATION OF DNA DAMAGE RESPONSE SIGNAL TRANSDUCTION BY P53 CLASS MEDIATOR 3 13 0.0004044 0.004913
384 INTRINSIC APOPTOTIC SIGNALING PATHWAY 8 152 0.0004068 0.004929
385 MUSCLE ORGAN DEVELOPMENT 11 277 0.0004106 0.004959
386 RESPONSE TO FIBROBLAST GROWTH FACTOR 7 116 0.0004124 0.004959
387 REGULATION OF PROTEIN SERINE THREONINE KINASE ACTIVITY 15 470 0.0004117 0.004959
388 NEGATIVE REGULATION OF CELLULAR COMPONENT ORGANIZATION 19 684 0.0004138 0.004963
389 PALLIUM DEVELOPMENT 8 153 0.000425 0.005083
390 POSITIVE REGULATION OF PHOSPHATE METABOLIC PROCESS 25 1036 0.0004389 0.005209
391 HISTONE METHYLATION 6 84 0.0004367 0.005209
392 POSITIVE REGULATION OF PHOSPHORUS METABOLIC PROCESS 25 1036 0.0004389 0.005209
393 REGULATION OF PEPTIDYL SERINE PHOSPHORYLATION 7 118 0.0004573 0.005414
394 REGULATION OF STRIATED MUSCLE CELL DIFFERENTIATION 6 85 0.0004654 0.005482
395 PALATE DEVELOPMENT 6 85 0.0004654 0.005482
396 POSITIVE REGULATION OF CANONICAL WNT SIGNALING PATHWAY 7 119 0.0004812 0.005654
397 ESTABLISHMENT OF LOCALIZATION IN CELL 35 1676 0.0004841 0.005674
398 ENDOCARDIAL CUSHION DEVELOPMENT 4 32 0.0004916 0.005718
399 PATTERNING OF BLOOD VESSELS 4 32 0.0004916 0.005718
400 INTRINSIC APOPTOTIC SIGNALING PATHWAY IN RESPONSE TO ENDOPLASMIC RETICULUM STRESS 4 32 0.0004916 0.005718
401 REGULATION OF STRESS ACTIVATED PROTEIN KINASE SIGNALING CASCADE 9 197 0.0005059 0.005848
402 HISTONE H3 K9 MODIFICATION 3 14 0.0005103 0.005848
403 POSITIVE REGULATION OF TRANSCRIPTION REGULATORY REGION DNA BINDING 3 14 0.0005103 0.005848
404 POSITIVE REGULATION OF MULTI ORGANISM PROCESS 8 157 0.0005047 0.005848
405 PEPTIDYL ARGININE METHYLATION 3 14 0.0005103 0.005848
406 POST EMBRYONIC ORGAN DEVELOPMENT 3 14 0.0005103 0.005848
407 REGULATION OF CYTOPLASMIC TRANSPORT 15 481 0.0005234 0.005984
408 REPRODUCTION 29 1297 0.0005287 0.006029
409 MRNA PROCESSING 14 432 0.0005501 0.006259
410 REGULATION OF CELL AGING 4 33 0.0005543 0.006291
411 REGULATION OF EPITHELIAL CELL DIFFERENTIATION 7 122 0.0005588 0.006312
412 CELLULAR RESPONSE TO CORTICOSTEROID STIMULUS 5 58 0.0005589 0.006312
413 NEGATIVE REGULATION OF CYSTEINE TYPE ENDOPEPTIDASE ACTIVITY 6 88 0.0005603 0.006313
414 NEGATIVE REGULATION OF APOPTOTIC SIGNALING PATHWAY 9 200 0.0005642 0.006341
415 MALE GAMETE GENERATION 15 486 0.0005822 0.006528
416 SKELETAL SYSTEM MORPHOGENESIS 9 201 0.0005848 0.006541
417 EPITHELIAL CELL PROLIFERATION 6 89 0.0005951 0.00664
418 POSITIVE REGULATION OF CELL MORPHOGENESIS INVOLVED IN DIFFERENTIATION 8 162 0.0006208 0.006911
419 REGULATION OF INTRINSIC APOPTOTIC SIGNALING PATHWAY IN RESPONSE TO DNA DAMAGE 4 34 0.0006226 0.006914
420 ENDOCARDIAL CUSHION FORMATION 3 15 0.0006324 0.006924
421 NEGATIVE REGULATION OF INTRINSIC APOPTOTIC SIGNALING PATHWAY 6 90 0.0006315 0.006924
422 MIDBRAIN DEVELOPMENT 6 90 0.0006315 0.006924
423 HISTONE H2A ACETYLATION 3 15 0.0006324 0.006924
424 POSITIVE REGULATION OF NUCLEASE ACTIVITY 3 15 0.0006324 0.006924
425 ACTIVATION OF ANAPHASE PROMOTING COMPLEX ACTIVITY 3 15 0.0006324 0.006924
426 HEAD DEVELOPMENT 19 709 0.0006393 0.006983
427 CHONDROCYTE DIFFERENTIATION 5 60 0.0006537 0.007124
428 MULTICELLULAR ORGANISM REPRODUCTION 20 768 0.0006595 0.007169
429 RESPONSE TO BIOTIC STIMULUS 22 886 0.0006713 0.007264
430 CATABOLIC PROCESS 36 1773 0.0006704 0.007264
431 RESPONSE TO EXTRACELLULAR STIMULUS 14 441 0.000673 0.007266
432 RESPONSE TO MINERALOCORTICOID 4 35 0.0006965 0.007502
433 NEGATIVE REGULATION OF CATION TRANSMEMBRANE TRANSPORT 5 61 0.0007055 0.007563
434 POSITIVE REGULATION OF STEM CELL PROLIFERATION 5 61 0.0007055 0.007563
435 MITOCHONDRIAL MEMBRANE ORGANIZATION 6 92 0.0007095 0.007589
436 CELLULAR CATABOLIC PROCESS 29 1322 0.000716 0.007641
437 MULTI ORGANISM REPRODUCTIVE PROCESS 22 891 0.0007229 0.007697
438 POSITIVE REGULATION OF CATALYTIC ACTIVITY 32 1518 0.0007376 0.007835
439 TRANSMEMBRANE RECEPTOR PROTEIN TYROSINE KINASE SIGNALING PATHWAY 15 498 0.0007468 0.007916
440 CELLULAR PROCESS INVOLVED IN REPRODUCTION IN MULTICELLULAR ORGANISM 10 252 0.0007517 0.00793
441 RHYTHMIC PROCESS 11 298 0.0007533 0.00793
442 REGULATION OF NEURON DEATH 10 252 0.0007517 0.00793
443 SOMITOGENESIS 5 62 0.0007602 0.007985
444 COPPER ION HOMEOSTASIS 3 16 0.0007717 0.008063
445 CELL SURFACE RECEPTOR SIGNALING PATHWAY INVOLVED IN HEART DEVELOPMENT 3 16 0.0007717 0.008063
446 LYMPHOCYTE DIFFERENTIATION 9 209 0.0007728 0.008063
447 PROTEIN K63 LINKED UBIQUITINATION 4 36 0.0007765 0.008065
448 REGULATION OF TRANSCRIPTION REGULATORY REGION DNA BINDING 4 36 0.0007765 0.008065
449 POSITIVE REGULATION OF PROTEIN LOCALIZATION TO NUCLEUS 7 129 0.0007789 0.008071
450 REGULATION OF CYTOSKELETON ORGANIZATION 15 502 0.0008098 0.008373
451 REGULATION OF CARTILAGE DEVELOPMENT 5 63 0.000818 0.00844
452 NEGATIVE REGULATION OF CYTOKINE PRODUCTION 9 211 0.0008268 0.008511
453 POSITIVE REGULATION OF RESPONSE TO DNA DAMAGE STIMULUS 5 64 0.0008791 0.009029
454 POSITIVE REGULATION OF APOPTOTIC SIGNALING PATHWAY 8 171 0.0008839 0.009059
455 POSITIVE REGULATION OF CELL DIVISION 7 132 0.0008919 0.009121
456 SEXUAL REPRODUCTION 19 730 0.0009041 0.009226
457 NUCLEOSOME DISASSEMBLY 3 17 0.0009291 0.009357
458 PROTEIN DNA COMPLEX DISASSEMBLY 3 17 0.0009291 0.009357
459 REGULATION OF CHROMATIN BINDING 3 17 0.0009291 0.009357
460 INNER MITOCHONDRIAL MEMBRANE ORGANIZATION 3 17 0.0009291 0.009357
461 CHROMATIN DISASSEMBLY 3 17 0.0009291 0.009357
462 PROTEIN LOCALIZATION 36 1805 0.0009261 0.009357
463 CELLULAR HOMEOSTASIS 18 676 0.0009528 0.009575
464 RIBOSOME BIOGENESIS 11 308 0.0009855 0.009882
465 SINGLE ORGANISM CELL ADHESION 14 459 0.0009895 0.009901
NumGOOverlapSizeP ValueAdj. P Value
1 TRANSCRIPTION FACTOR ACTIVITY PROTEIN BINDING 40 588 1.116e-19 1.037e-16
2 MACROMOLECULAR COMPLEX BINDING 55 1399 5.307e-16 2.465e-13
3 TRANSCRIPTION FACTOR BINDING 33 524 2.29e-15 7.09e-13
4 CHROMATIN BINDING 29 435 3.062e-14 7.111e-12
5 SEQUENCE SPECIFIC DNA BINDING 43 1037 2.5e-13 4.646e-11
6 ENZYME BINDING 57 1737 3.34e-13 5.172e-11
7 REGULATORY REGION NUCLEIC ACID BINDING 37 818 1.151e-12 1.528e-10
8 DOUBLE STRANDED DNA BINDING 35 764 3.537e-12 4.108e-10
9 TRANSCRIPTION COACTIVATOR ACTIVITY 22 296 5.494e-12 5.671e-10
10 NUCLEIC ACID BINDING TRANSCRIPTION FACTOR ACTIVITY 40 1199 1.364e-09 1.152e-07
11 ADENYL NUCLEOTIDE BINDING 46 1514 1.304e-09 1.152e-07
12 RIBONUCLEOTIDE BINDING 51 1860 4.614e-09 3.572e-07
13 RNA POLYMERASE II TRANSCRIPTION FACTOR ACTIVITY SEQUENCE SPECIFIC DNA BINDING 27 629 5.226e-09 3.735e-07
14 TRANSCRIPTION FACTOR ACTIVITY RNA POLYMERASE II CORE PROMOTER PROXIMAL REGION SEQUENCE SPECIFIC BINDING 19 328 1.036e-08 6.872e-07
15 TRANSFERASE ACTIVITY TRANSFERRING PHOSPHORUS CONTAINING GROUPS 34 992 1.437e-08 8.899e-07
16 RNA BINDING 45 1598 2.083e-08 1.209e-06
17 CYCLIN DEPENDENT PROTEIN KINASE ACTIVITY 7 34 1.064e-07 5.813e-06
18 PROTEIN KINASE ACTIVITY 25 640 1.239e-07 6.395e-06
19 KINASE BINDING 24 606 1.751e-07 7.88e-06
20 TRANSCRIPTIONAL ACTIVATOR ACTIVITY RNA POLYMERASE II TRANSCRIPTION REGULATORY REGION SEQUENCE SPECIFIC BINDING 17 315 1.75e-07 7.88e-06
21 IDENTICAL PROTEIN BINDING 36 1209 1.781e-07 7.88e-06
22 CHAPERONE BINDING 9 81 4.114e-07 1.737e-05
23 POLY A RNA BINDING 34 1170 7.143e-07 2.885e-05
24 PROTEIN SERINE THREONINE KINASE ACTIVITY 19 445 1.185e-06 4.586e-05
25 KINASE ACTIVITY 27 842 1.82e-06 6.763e-05
26 TRANSCRIPTION COREPRESSOR ACTIVITY 13 221 1.972e-06 7.044e-05
27 PROTEIN DIMERIZATION ACTIVITY 32 1149 3.856e-06 0.0001327
28 HORMONE RECEPTOR BINDING 11 168 4.414e-06 0.0001465
29 TRANSCRIPTION FACTOR ACTIVITY RNA POLYMERASE II DISTAL ENHANCER SEQUENCE SPECIFIC BINDING 8 90 9.942e-06 0.0003185
30 PROTEIN HOMODIMERIZATION ACTIVITY 23 722 1.234e-05 0.000361
31 PROTEIN COMPLEX BINDING 27 935 1.243e-05 0.000361
32 PEPTIDE N ACETYLTRANSFERASE ACTIVITY 7 67 1.243e-05 0.000361
33 TRANSCRIPTIONAL ACTIVATOR ACTIVITY RNA POLYMERASE II CORE PROMOTER PROXIMAL REGION SEQUENCE SPECIFIC BINDING 12 226 1.388e-05 0.0003792
34 UBIQUITIN LIKE PROTEIN LIGASE BINDING 13 264 1.362e-05 0.0003792
35 SMAD BINDING 7 72 2.004e-05 0.000532
36 N ACYLTRANSFERASE ACTIVITY 8 104 2.875e-05 0.0007419
37 HISTONE DEACETYLASE BINDING 8 105 3.081e-05 0.0007533
38 CORE PROMOTER PROXIMAL REGION DNA BINDING 15 371 3.062e-05 0.0007533
39 NOTCH BINDING 4 18 4.751e-05 0.001132
40 HISTONE METHYLTRANSFERASE ACTIVITY 6 58 5.585e-05 0.001297
41 N ACETYLTRANSFERASE ACTIVITY 7 87 6.862e-05 0.001555
42 CORE PROMOTER BINDING 9 152 7.261e-05 0.001596
43 TBP CLASS PROTEIN BINDING 4 20 7.387e-05 0.001596
44 SINGLE STRANDED DNA BINDING 7 93 0.0001049 0.002215
45 PROTEIN HETERODIMERIZATION ACTIVITY 16 468 0.0001219 0.002461
46 RIBONUCLEOPROTEIN COMPLEX BINDING 7 95 0.00012 0.002461
47 PROTEIN DEACETYLASE ACTIVITY 5 43 0.0001352 0.002672
48 NUCLEOTIDYLTRANSFERASE ACTIVITY 8 131 0.0001478 0.00286
49 ACETYLTRANSFERASE ACTIVITY 7 103 0.000199 0.003772
50 RNA POLYMERASE I ACTIVITY 3 12 0.0003137 0.005605
51 DNA DEPENDENT ATPASE ACTIVITY 6 79 0.0003133 0.005605
52 TRANSFERASE ACTIVITY TRANSFERRING ONE CARBON GROUPS 10 225 0.0003102 0.005605
53 NAD BINDING 5 53 0.0003668 0.006196
54 STEROID HORMONE RECEPTOR BINDING 6 81 0.0003589 0.006196
55 DNA HELICASE ACTIVITY 5 53 0.0003668 0.006196
56 PROTEIN METHYLTRANSFERASE ACTIVITY 6 82 0.0003835 0.006362
57 BETA CATENIN BINDING 6 84 0.0004367 0.006876
58 HELICASE ACTIVITY 8 153 0.000425 0.006876
59 DEACETYLASE ACTIVITY 5 55 0.0004364 0.006876
60 N METHYLTRANSFERASE ACTIVITY 6 88 0.0005603 0.008533
61 RRNA BINDING 5 58 0.0005589 0.008533
62 HEAT SHOCK PROTEIN BINDING 6 89 0.0005951 0.008856
63 HYDROLASE ACTIVITY ACTING ON ACID ANHYDRIDES 21 820 0.0006006 0.008856
NumGOOverlapSizeP ValueAdj. P Value
1 TRANSFERASE COMPLEX 41 703 9.422e-18 5.502e-15
2 CHROMOSOME 44 880 1.579e-16 4.61e-14
3 NUCLEOPLASM PART 38 708 2.554e-15 3.989e-13
4 CATALYTIC COMPLEX 46 1038 2.732e-15 3.989e-13
5 TRANSCRIPTION FACTOR COMPLEX 25 298 1.143e-14 1.335e-12
6 RNA POLYMERASE II TRANSCRIPTION FACTOR COMPLEX 16 101 4.27e-14 4.156e-12
7 TRANSFERASE COMPLEX TRANSFERRING PHOSPHORUS CONTAINING GROUPS 22 237 6.127e-14 5.112e-12
8 NUCLEAR TRANSCRIPTION FACTOR COMPLEX 17 127 1.193e-13 8.707e-12
9 NUCLEAR CHROMOSOME 28 523 1.741e-11 1.13e-09
10 CHROMATIN 25 441 6.816e-11 3.981e-09
11 DNA DIRECTED RNA POLYMERASE II HOLOENZYME 13 97 9.693e-11 5.146e-09
12 RNA POLYMERASE COMPLEX 14 122 1.523e-10 7.413e-09
13 ACETYLTRANSFERASE COMPLEX 11 100 2.31e-08 1.038e-06
14 NUCLEOLUS 30 848 5.595e-08 2.334e-06
15 CHROMOSOMAL REGION 18 330 6.403e-08 2.493e-06
16 CARBOXY TERMINAL DOMAIN PROTEIN KINASE COMPLEX 6 22 1.459e-07 5.325e-06
17 PROTEIN KINASE COMPLEX 9 90 1.018e-06 3.301e-05
18 METHYLTRANSFERASE COMPLEX 9 90 1.018e-06 3.301e-05
19 CYCLIN DEPENDENT PROTEIN KINASE HOLOENZYME COMPLEX 6 31 1.319e-06 4.055e-05
20 NUCLEAR PERIPHERY 10 121 1.494e-06 4.363e-05
21 HISTONE METHYLTRANSFERASE COMPLEX 8 71 1.648e-06 4.584e-05
22 NUCLEAR MATRIX 9 98 2.092e-06 5.554e-05
23 NUCLEAR CHROMATIN 14 291 8.254e-06 0.0002096
24 RIBONUCLEOPROTEIN COMPLEX 23 721 1.207e-05 0.0002936
25 CYTOSKELETON 44 1967 1.564e-05 0.0003572
26 MLL1 2 COMPLEX 5 28 1.59e-05 0.0003572
27 CONDENSED NUCLEAR CHROMOSOME CENTROMERIC REGION 4 18 4.751e-05 0.001028
28 H4 HISTONE ACETYLTRANSFERASE COMPLEX 4 19 5.964e-05 0.001244
29 CYTOSOLIC PART 11 223 6.202e-05 0.001249
30 CELL SUBSTRATE JUNCTION 15 398 6.799e-05 0.001324
31 NUCLEOLAR PART 6 62 8.162e-05 0.001538
32 CONDENSED CHROMOSOME 10 195 9.71e-05 0.001772
33 MICROTUBULE CYTOSKELETON 27 1068 0.0001213 0.002083
34 CHROMOSOME TELOMERIC REGION 9 162 0.0001184 0.002083
35 HETEROCHROMATIN 6 67 0.0001263 0.002107
36 CHROMOSOME CENTROMERIC REGION 9 174 0.000203 0.003204
37 ANCHORING JUNCTION 16 489 0.0002007 0.003204
38 CYTOSOLIC PROTEASOME COMPLEX 3 11 0.0002373 0.003648
39 HOLO TFIIH COMPLEX 3 12 0.0003137 0.004581
40 PROTEASOME REGULATORY PARTICLE BASE SUBCOMPLEX 3 12 0.0003137 0.004581
41 MICROTUBULE ORGANIZING CENTER 18 623 0.0003696 0.005265
42 DNA DIRECTED RNA POLYMERASE I COMPLEX 3 13 0.0004044 0.005623
43 CONDENSED NUCLEAR CHROMOSOME 6 85 0.0004654 0.006321
44 DNA HELICASE COMPLEX 3 14 0.0005103 0.006773
45 CENTROSOME 15 487 0.0005947 0.007717
46 NUCLEAR CYCLIN DEPENDENT PROTEIN KINASE HOLOENZYME COMPLEX 3 15 0.0006324 0.007858
47 XY BODY 3 15 0.0006324 0.007858
48 REPLICATION FORK 5 62 0.0007602 0.009249

Over-represented Pathway

NumPathwayPathviewOverlapSizeP ValueAdj. P Value
1 hsa04110_Cell_cycle 16 128 1.891e-12 3.403e-10
2 hsa04914_Progesterone.mediated_oocyte_maturation 12 87 3.679e-10 3.311e-08
3 hsa03022_Basal_transcription_factors 7 37 1.977e-07 1.186e-05
4 hsa04114_Oocyte_meiosis 10 114 8.625e-07 3.881e-05
5 hsa04390_Hippo_signaling_pathway 11 154 1.894e-06 6.817e-05
6 hsa04010_MAPK_signaling_pathway 13 268 1.597e-05 0.0004237
7 hsa04330_Notch_signaling_pathway 6 47 1.648e-05 0.0004237
8 hsa00240_Pyrimidine_metabolism 8 99 2.008e-05 0.0004518
9 hsa04115_p53_signaling_pathway 6 69 0.0001488 0.002975
10 hsa04520_Adherens_junction 6 73 0.0002033 0.003659
11 hsa03020_RNA_polymerase 4 29 0.0003336 0.00546
12 hsa04310_Wnt_signaling_pathway 8 151 0.0003892 0.005838
13 hsa04722_Neurotrophin_signaling_pathway 7 127 0.00071 0.009563
14 hsa04380_Osteoclast_differentiation 7 128 0.0007438 0.009563
15 hsa04960_Aldosterone.regulated_sodium_reabsorption 4 42 0.001398 0.01677
16 hsa03420_Nucleotide_excision_repair 4 45 0.001811 0.02037
17 hsa04510_Focal_adhesion 8 200 0.002385 0.0245
18 hsa04670_Leukocyte_transendothelial_migration 6 117 0.00245 0.0245
19 hsa03010_Ribosome 5 92 0.004366 0.04136
20 hsa04120_Ubiquitin_mediated_proteolysis 6 139 0.005706 0.05136
21 hsa04660_T_cell_receptor_signaling_pathway 5 108 0.008532 0.07313
22 hsa04622_RIG.I.like_receptor_signaling_pathway 4 71 0.009348 0.07648
23 hsa03450_Non.homologous_end.joining 2 14 0.01112 0.08499
24 hsa00230_Purine_metabolism 6 162 0.01169 0.08499
25 hsa04370_VEGF_signaling_pathway 4 76 0.0118 0.08499
26 hsa04664_Fc_epsilon_RI_signaling_pathway 4 79 0.01346 0.09188
27 hsa04141_Protein_processing_in_endoplasmic_reticulum 6 168 0.01378 0.09188
28 hsa03050_Proteasome 3 45 0.01528 0.09826
29 hsa04620_Toll.like_receptor_signaling_pathway 4 102 0.03105 0.1868
30 hsa04621_NOD.like_receptor_signaling_pathway 3 59 0.03114 0.1868
31 hsa03013_RNA_transport 5 152 0.03233 0.1877
32 hsa00970_Aminoacyl.tRNA_biosynthesis 3 63 0.03679 0.2069
33 hsa04720_Long.term_potentiation 3 70 0.04784 0.261
34 hsa04151_PI3K_AKT_signaling_pathway 8 351 0.05283 0.2797
35 hsa03030_DNA_replication 2 36 0.06524 0.3355
36 hsa04530_Tight_junction 4 133 0.06938 0.3375
37 hsa04012_ErbB_signaling_pathway 3 87 0.08052 0.3814
38 hsa04210_Apoptosis 3 89 0.08487 0.3917
39 hsa04144_Endocytosis 5 203 0.08809 0.3964
40 hsa04973_Carbohydrate_digestion_and_absorption 2 44 0.09232 0.4053
41 hsa04810_Regulation_of_actin_cytoskeleton 5 214 0.1042 0.4467
42 hsa04912_GnRH_signaling_pathway 3 101 0.1129 0.4517
43 hsa04916_Melanogenesis 3 101 0.1129 0.4517
44 hsa04150_mTOR_signaling_pathway 2 52 0.122 0.4673
45 hsa04623_Cytosolic_DNA.sensing_pathway 2 56 0.1376 0.5161
46 hsa00010_Glycolysis_._Gluconeogenesis 2 65 0.1741 0.6268
47 hsa03040_Spliceosome 3 128 0.1862 0.6444
48 hsa04730_Long.term_depression 2 70 0.195 0.6623
49 hsa04971_Gastric_acid_secretion 2 74 0.2119 0.691
50 hsa04910_Insulin_signaling_pathway 3 138 0.2159 0.691
51 hsa04662_B_cell_receptor_signaling_pathway 2 75 0.2162 0.691
52 hsa04260_Cardiac_muscle_contraction 2 77 0.2247 0.691
53 hsa04612_Antigen_processing_and_presentation 2 78 0.229 0.691
54 hsa03008_Ribosome_biogenesis_in_eukaryotes 2 81 0.2418 0.691
55 hsa04974_Protein_digestion_and_absorption 2 81 0.2418 0.691
56 hsa04350_TGF.beta_signaling_pathway 2 85 0.259 0.7285
57 hsa04630_Jak.STAT_signaling_pathway 3 155 0.2683 0.7403
58 hsa04145_Phagosome 3 156 0.2714 0.7403
59 hsa04540_Gap_junction 2 90 0.2805 0.7426
60 hsa04062_Chemokine_signaling_pathway 3 189 0.3758 0.9019
61 hsa04360_Axon_guidance 2 130 0.4464 1
62 hsa00190_Oxidative_phosphorylation 2 132 0.4542 1
63 hsa04650_Natural_killer_cell_mediated_cytotoxicity 2 136 0.4695 1
64 hsa04014_Ras_signaling_pathway 3 236 0.5176 1

lncRNA-mediated sponge

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Num lncRNA miRNAs           miRNAs count     Gene Sponge regulatory network lncRNA log2FC lncRNA pvalue Gene log2FC Gene pvalue lncRNA-gene Pearson correlation
1 RP11-531A24.5 hsa-miR-17-5p;hsa-miR-181a-5p;hsa-miR-181b-5p;hsa-miR-19a-3p;hsa-miR-19b-3p;hsa-miR-20a-3p;hsa-miR-20a-5p;hsa-miR-29a-5p;hsa-miR-576-5p;hsa-miR-92a-3p 10 KAT2B Sponge network -1.752 0 -1.005 2.0E-5 0.38

Quest ID: 75bcfd9268f4f21f15d15d1126694a24