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This regulatory network was inferred from the input dataset. The miRNAs and mRNAs are presented as round and rectangle nodes respectively. The numerical value popped up upon mouse over the gene node is the log2 transformed fold-change of the gene expression between the two groups. All of the nodes are clickable, and the detailed information of the miRNAs/mRNAs and related cancer pathway will be displayed in another window. The edges between nodes are supported by both interactions (predicted or experimentally verified) and correlations learnt from cancer dataset. The numerical value popped up upon mouse over the edge is the correlation beat value (effect size) between the two nodes. The experimental evidences of the edges reported in previous cancer studies are highlighted by red/orange color. All of these information can be accessed by the "mouse-over" action. This network shows a full map of the miRNA-mRNA regulation of the input gene list(s), and the hub miRNAs (with the high network degree/betweenness centrality) would be the potential cancer drivers or tumor suppressors. The full result table can be accessed in the "Regulations" tab.

"miRNACancerMAP" is also a network visualization tool for users to draw their regulatory network by personal customization. Users can set the complexity of the network by limiting the number of nodes or edges. And the color of the nodes can be defined by different categories of the mRNAs and miRNAs, such as Gene-Ontology, pathway, and expression status. Users can also select to use network degree or network betweenness centrality to define the node size. And edges can be black or colored by the correlation. Purple edge means negative correlation (mostly found between miRNA and mRNA), and blue edge means positive correlation (found in PPI or miRNA-miRNA sponge effect). We can also add the protein-protein interactions (PPI) into the network. This result will show the cluster of genes regulated by some specific miRNAs. Additionally, miRNA-miRNA edges can be added by the "miRNA sponge" button, presenting some clusters of miRNAs that have the interactions via sponge effect.

miRNA-gene regulations

(Download full result)

Num microRNA           Gene miRNA log2FC miRNA pvalue Gene log2FC Gene pvalue Interaction Correlation beta Correlation P-value PMID Reported in cancer studies
1 hsa-miR-378a-3p ADM2 -1.8 0 2.41 0 mirMAP -0.2 0 NA
2 hsa-miR-337-3p ANP32E -2.14 0 0.4 0.00074 MirTarget; PITA; miRNATAP -0.11 1.0E-5 NA
3 hsa-miR-378a-3p ARL8B -1.8 0 0.2 0.00076 MirTarget; miRNATAP -0.11 0 NA
4 hsa-miR-378a-3p B4GALNT3 -1.8 0 1.51 0 miRNAWalker2 validate -0.27 0 NA
5 hsa-miR-378a-3p BRD3 -1.8 0 0.22 0.00061 miRNATAP -0.11 0 NA
6 hsa-miR-378a-3p C1orf21 -1.8 0 -0.47 0.00106 miRNATAP -0.15 0 NA
7 hsa-miR-378c C1orf21 -1.8 0 -0.47 0.00106 miRNATAP -0.19 0 NA
8 hsa-miR-337-3p CDC25A -2.14 0 2.05 0 mirMAP -0.35 0 NA
9 hsa-miR-337-3p CDCA4 -2.14 0 1.24 0 MirTarget -0.19 0 NA
10 hsa-miR-378a-3p CELSR3 -1.8 0 2.04 0 MirTarget -0.29 0 NA
11 hsa-miR-378c CELSR3 -1.8 0 2.04 0 MirTarget -0.29 0 NA
12 hsa-miR-378a-3p CENPP -1.8 0 1.39 0 mirMAP -0.25 0 NA
13 hsa-miR-378c CENPP -1.8 0 1.39 0 mirMAP -0.29 0 NA
14 hsa-miR-337-3p CHAF1A -2.14 0 1.08 0 PITA -0.24 0 NA
15 hsa-miR-378a-3p CNTD2 -1.8 0 2.71 0 MirTarget -0.58 0 NA
16 hsa-miR-378c CNTD2 -1.8 0 2.71 0 MirTarget -0.55 0 NA
17 hsa-miR-378a-3p CPD -1.8 0 -0.24 0.02078 MirTarget -0.15 0 NA
18 hsa-miR-378c CPD -1.8 0 -0.24 0.02078 MirTarget -0.12 0 NA
19 hsa-miR-378a-3p CPLX2 -1.8 0 1.27 0.00039 mirMAP -0.36 3.0E-5 NA
20 hsa-miR-378c CPLX2 -1.8 0 1.27 0.00039 mirMAP -0.34 0.0001 NA
21 hsa-miR-378c CSNK1G1 -1.8 0 0.25 0.00027 miRNATAP -0.12 0 NA
22 hsa-miR-378c CUEDC1 -1.8 0 0.54 0 miRNATAP -0.18 0 NA
23 hsa-miR-378c DACT1 -1.8 0 0.22 0.11609 miRNATAP -0.13 8.0E-5 NA
24 hsa-miR-378a-3p DAZAP2 -1.8 0 0.05 0.32954 MirTarget; miRNATAP -0.13 0 NA
25 hsa-miR-378c DAZAP2 -1.8 0 0.05 0.32954 MirTarget; miRNATAP -0.12 0 NA
26 hsa-miR-378a-3p DCTN4 -1.8 0 -0.12 0.07829 miRNAWalker2 validate -0.13 0 NA
27 hsa-miR-337-3p DSCC1 -2.14 0 1.08 0 MirTarget -0.21 0 NA
28 hsa-miR-337-3p E2F5 -2.14 0 1.22 0 MirTarget; PITA -0.23 0 NA
29 hsa-miR-378a-3p E2F5 -1.8 0 1.22 0 miRNAWalker2 validate -0.19 0 NA
30 hsa-miR-337-3p ECE2 -2.14 0 1.89 0 PITA -0.32 0 NA
31 hsa-miR-378a-3p EDARADD -1.8 0 -0.02 0.91132 miRNAWalker2 validate -0.14 0.00338 NA
32 hsa-miR-378c EFR3B -1.8 0 0.73 0 mirMAP -0.27 0 NA
33 hsa-miR-378c ELFN2 -1.8 0 1.01 7.0E-5 miRNATAP -0.23 0.00018 NA
34 hsa-miR-378a-3p FCGR1A -1.8 0 2.08 0 MirTarget -0.21 0 NA
35 hsa-miR-378c FCGR1A -1.8 0 2.08 0 MirTarget -0.19 0 NA
36 hsa-miR-378a-3p FCGR1B -1.8 0 1.64 0 MirTarget -0.15 0 NA
37 hsa-miR-378c FCGR1B -1.8 0 1.64 0 MirTarget -0.14 2.0E-5 NA
38 hsa-miR-337-3p FGFR3 -2.14 0 1.87 0 MirTarget -0.28 0 NA
39 hsa-miR-337-3p FLVCR1 -2.14 0 1.31 0 MirTarget -0.12 0 NA
40 hsa-miR-378a-3p FMN1 -1.8 0 -0.1 0.62996 mirMAP -0.34 0 NA
41 hsa-miR-378c FMN1 -1.8 0 -0.1 0.62996 mirMAP -0.21 1.0E-5 NA
42 hsa-miR-337-3p FRAT2 -2.14 0 0.92 0 MirTarget; PITA -0.17 0 NA
43 hsa-miR-378a-3p GALNT6 -1.8 0 1.53 0 MirTarget -0.57 0 NA
44 hsa-miR-378c GALNT6 -1.8 0 1.53 0 MirTarget -0.58 0 NA
45 hsa-miR-378a-3p GALNT7 -1.8 0 1.09 0 miRNAWalker2 validate -0.44 0 NA
46 hsa-miR-337-3p GMPPB -2.14 0 0.91 0 mirMAP -0.14 0 NA
47 hsa-miR-378a-3p GOLT1A -1.8 0 2.04 0 MirTarget; miRNATAP -0.43 0 26255816 miR 378a 3p modulates tamoxifen sensitivity in breast cancer MCF 7 cells through targeting GOLT1A; GOLT1A was selected as one of the miR-378a-3p candidate target genes by in silico analysis
48 hsa-miR-378c GOLT1A -1.8 0 2.04 0 MirTarget; miRNATAP -0.42 0 NA
49 hsa-miR-378a-3p GRB2 -1.8 0 0.64 0 miRNAWalker2 validate; MirTarget; miRNATAP -0.13 0 NA
50 hsa-miR-378c GRB2 -1.8 0 0.64 0 MirTarget; miRNATAP -0.13 0 NA
51 hsa-miR-378a-3p GRIK2 -1.8 0 -0.15 0.41613 miRNATAP -0.12 0.00832 NA
52 hsa-miR-378c GRIK2 -1.8 0 -0.15 0.41613 miRNATAP -0.18 0.0001 NA
53 hsa-miR-378a-3p GRIK3 -1.8 0 -0.9 0.00309 MirTarget; mirMAP -0.64 0 NA
54 hsa-miR-378c GRIK3 -1.8 0 -0.9 0.00309 MirTarget; mirMAP -0.58 0 NA
55 hsa-miR-337-3p HAPLN1 -2.14 0 3.74 0 MirTarget; mirMAP -0.37 0 NA
56 hsa-miR-378a-3p HIST1H2BD -1.8 0 2.62 0 miRNAWalker2 validate -0.57 0 NA
57 hsa-miR-378a-3p HIST1H3H -1.8 0 3.64 0 miRNAWalker2 validate -0.51 0 NA
58 hsa-miR-337-3p HMGB3 -2.14 0 2.15 0 mirMAP -0.3 0 NA
59 hsa-miR-337-3p HPSE -2.14 0 0.77 0 MirTarget -0.15 0 NA
60 hsa-miR-378a-3p IGF1R -1.8 0 0.12 0.48217 miRTarBase; MirTarget; miRNATAP -0.41 0 24119742; 25427715; 24412052 The insulin-like growth factor 1 receptor IGF1R was predicted as a potential target of miR-378 and luciferase reporter activity of IGF1R was significantly decreased in the HEK293 cells co-transfected with miR-378 by 41.8% vs the control cells P less than 0.01; miR-378 may suppress growth characteristics of HBV-related HCC by directly targeting the IGF1R 3'-UTR and inhibiting its protein expression;Interestingly members of the miR-378 family presented as a possible target the insulin-like growth factor receptor 1 IGF1R a key signalling molecule in RMS; MiR-378a-3p over-expression in an RMS-derived cell line suppressed IGF1R expression and affected phosphorylated-Akt protein levels;Furthermore miR-378a-3p over-expression or down-regulation could inhibit or enhance insulin-like growth factor 1 receptor IGF1R expression in CRC cells; There was a significantly negative correlation between IGF1R protein expression and miR-378a-3p expression in CRC tissues
61 hsa-miR-378c IGF1R -1.8 0 0.12 0.48217 MirTarget; miRNATAP -0.37 0 NA
62 hsa-miR-378a-3p IL6ST -1.8 0 -1.53 0 miRNATAP -0.3 0 NA
63 hsa-miR-378c IL6ST -1.8 0 -1.53 0 miRNATAP -0.17 0.0075 NA
64 hsa-miR-378c IQSEC2 -1.8 0 0.44 0 miRNATAP -0.18 0 NA
65 hsa-miR-378a-3p IVD -1.8 0 -0.02 0.81042 mirMAP -0.19 0 NA
66 hsa-miR-378c IVD -1.8 0 -0.02 0.81042 mirMAP -0.19 0 NA
67 hsa-miR-378a-3p KCNC1 -1.8 0 -0.42 0.12578 mirMAP -0.27 4.0E-5 NA
68 hsa-miR-378c KCNC1 -1.8 0 -0.42 0.12578 mirMAP -0.26 0.00012 NA
69 hsa-miR-378c KIAA1522 -1.8 0 0.93 0 miRNATAP -0.26 0 NA
70 hsa-miR-378a-3p KIF6 -1.8 0 0.23 0.18754 mirMAP -0.3 0 NA
71 hsa-miR-378c KIF6 -1.8 0 0.23 0.18754 mirMAP -0.24 0 NA
72 hsa-miR-378c LBX2 -1.8 0 1.72 0 miRNATAP -0.21 0 NA
73 hsa-miR-337-3p LHFPL5 -2.14 0 2.63 0 MirTarget -0.21 0.00063 NA
74 hsa-miR-378a-3p LMX1B -1.8 0 0.89 1.0E-5 mirMAP -0.63 0 NA
75 hsa-miR-378c LMX1B -1.8 0 0.89 1.0E-5 mirMAP -0.61 0 NA
76 hsa-miR-378c LRP10 -1.8 0 -0.04 0.56835 mirMAP -0.11 0 NA
77 hsa-miR-378c MDGA1 -1.8 0 -0.06 0.63991 mirMAP -0.11 0.00068 NA
78 hsa-miR-378c MED12L -1.8 0 0.34 0.08715 miRNATAP -0.19 7.0E-5 NA
79 hsa-miR-378c MKL2 -1.8 0 -0.56 0 miRNATAP -0.17 0 NA
80 hsa-miR-378a-3p MPP3 -1.8 0 0.46 5.0E-5 MirTarget -0.11 7.0E-5 NA
81 hsa-miR-378c MPP3 -1.8 0 0.46 5.0E-5 MirTarget -0.15 0 NA
82 hsa-miR-378c MREG -1.8 0 0.79 0 miRNATAP -0.3 0 NA
83 hsa-miR-378a-3p NCAPG -1.8 0 3.02 0 MirTarget -0.22 0 NA
84 hsa-miR-378c NCAPG -1.8 0 3.02 0 MirTarget -0.23 0 NA
85 hsa-miR-378a-3p NDE1 -1.8 0 0.88 0 miRNAWalker2 validate -0.19 0 NA
86 hsa-miR-378a-3p NDFIP1 -1.8 0 -0.13 0.02626 miRNAWalker2 validate -0.11 0 NA
87 hsa-miR-378a-3p NEBL -1.8 0 0.36 0.00633 mirMAP -0.36 0 NA
88 hsa-miR-378c NEBL -1.8 0 0.36 0.00633 mirMAP -0.28 0 NA
89 hsa-miR-378a-3p NME4 -1.8 0 0.95 0 miRNAWalker2 validate -0.16 0 NA
90 hsa-miR-378a-3p NPNT -1.8 0 1.31 0 miRNAWalker2 validate -0.63 0 NA
91 hsa-miR-378a-3p NUFIP2 -1.8 0 0.14 0.06726 miRNATAP -0.11 0 NA
92 hsa-miR-378a-3p OCRL -1.8 0 0.12 0.07422 miRNAWalker2 validate -0.11 0 NA
93 hsa-miR-378c OTUB2 -1.8 0 1.05 0 miRNATAP -0.22 0 NA
94 hsa-miR-378c PDIA4 -1.8 0 1.19 0 MirTarget; miRNATAP -0.12 0 NA
95 hsa-miR-378c PDIK1L -1.8 0 0.47 0 miRNATAP -0.14 0 NA
96 hsa-miR-337-3p PRR12 -2.14 0 0.51 0 MirTarget; PITA -0.11 0 NA
97 hsa-miR-378a-3p PTGES3 -1.8 0 0.34 0 MirTarget -0.1 0 NA
98 hsa-miR-378a-3p QSOX1 -1.8 0 0.6 0 mirMAP -0.18 0 NA
99 hsa-miR-378c QSOX1 -1.8 0 0.6 0 mirMAP -0.22 0 NA
100 hsa-miR-378a-3p RABEP2 -1.8 0 1.44 0 miRNAWalker2 validate -0.18 0 NA
101 hsa-miR-378c RIMS4 -1.8 0 1.94 0 miRNATAP -0.93 0 NA
102 hsa-miR-378a-3p SLC1A2 -1.8 0 0.46 0.04286 mirMAP -0.62 0 NA
103 hsa-miR-378c SLC1A2 -1.8 0 0.46 0.04286 mirMAP -0.52 0 NA
104 hsa-miR-378a-3p SLC22A23 -1.8 0 -0.24 0.02826 miRNAWalker2 validate; mirMAP -0.1 8.0E-5 NA
105 hsa-miR-378a-3p SLC2A1 -1.8 0 1.5 0 MirTarget -0.15 0 NA
106 hsa-miR-378c SLC2A1 -1.8 0 1.5 0 MirTarget; miRNATAP -0.17 0 NA
107 hsa-miR-378c SLC30A8 -1.8 0 2.08 2.0E-5 miRNATAP -0.83 0 NA
108 hsa-miR-378c SLC39A9 -1.8 0 0.26 9.0E-5 miRNATAP -0.19 0 NA
109 hsa-miR-337-3p SMARCB1 -2.14 0 0.61 0 PITA -0.1 0 NA
110 hsa-miR-378a-3p SMPD3 -1.8 0 0.62 0.00021 mirMAP -0.35 0 NA
111 hsa-miR-378c SMPD3 -1.8 0 0.62 0.00021 mirMAP -0.3 0 NA
112 hsa-miR-378c SPOPL -1.8 0 0.22 0.02518 miRNATAP -0.24 0 NA
113 hsa-miR-378a-3p SPTLC2 -1.8 0 -0.09 0.33706 miRNATAP -0.13 0 NA
114 hsa-miR-378a-3p SREBF1 -1.8 0 1.02 0 miRNAWalker2 validate -0.3 0 NA
115 hsa-miR-378a-3p SRGAP1 -1.8 0 0.04 0.67595 mirMAP -0.14 0 NA
116 hsa-miR-378c SRGAP1 -1.8 0 0.04 0.67595 mirMAP -0.13 0 NA
117 hsa-miR-337-3p SSX2IP -2.14 0 1.3 0 mirMAP -0.12 0 NA
118 hsa-miR-378a-3p SULF1 -1.8 0 1.46 0 MirTarget; miRNATAP -0.26 0 NA
119 hsa-miR-378c SULF1 -1.8 0 1.46 0 MirTarget; miRNATAP -0.29 0 NA
120 hsa-miR-337-3p SYCP2 -2.14 0 1.05 0 MirTarget -0.19 0 NA
121 hsa-miR-378c TBX6 -1.8 0 0.58 0 miRNATAP -0.19 0 NA
122 hsa-miR-378c TMCO1 -1.8 0 0.85 0 miRNATAP -0.19 0 NA
123 hsa-miR-378a-3p TMED8 -1.8 0 0.17 0.00546 mirMAP -0.14 0 NA
124 hsa-miR-378a-3p TMEM130 -1.8 0 -0.15 0.43377 MirTarget -0.19 3.0E-5 NA
125 hsa-miR-378c TMEM130 -1.8 0 -0.15 0.43377 MirTarget -0.13 0.00663 NA
126 hsa-miR-378a-3p TMEM199 -1.8 0 0.58 0 miRNAWalker2 validate -0.17 0 NA
127 hsa-miR-378a-3p TRAFD1 -1.8 0 0.55 0 miRNAWalker2 validate -0.13 0 NA
128 hsa-miR-378c TRIL -1.8 0 -0.09 0.49347 miRNATAP -0.16 0 NA
129 hsa-miR-378a-3p TRIM62 -1.8 0 0.79 0 MirTarget -0.2 0 NA
130 hsa-miR-378c TRIM62 -1.8 0 0.79 0 MirTarget -0.2 0 NA
131 hsa-miR-378c TSPAN17 -1.8 0 1.01 0 miRNATAP -0.11 0 NA
132 hsa-miR-337-3p TTC13 -2.14 0 0.62 0 MirTarget; PITA -0.13 0 NA
133 hsa-miR-378a-3p TUSC2 -1.8 0 0.3 0 miRNAWalker2 validate; miRTarBase -0.1 0 NA
134 hsa-miR-378a-3p TWF1 -1.8 0 0.31 1.0E-5 MirTarget -0.14 0 NA
135 hsa-miR-378c TWF1 -1.8 0 0.31 1.0E-5 MirTarget -0.15 0 NA
136 hsa-miR-378a-3p UHRF1 -1.8 0 3.82 0 MirTarget -0.37 0 NA
137 hsa-miR-378c UHRF1 -1.8 0 3.82 0 MirTarget -0.39 0 NA
138 hsa-miR-378c VANGL1 -1.8 0 0.83 0 miRNATAP -0.13 0 NA
139 hsa-miR-378a-3p VPS13B -1.8 0 -0.13 0.17494 mirMAP -0.11 0 NA
140 hsa-miR-378a-3p WDR31 -1.8 0 -0.52 0.0008 MirTarget -0.22 0 NA
141 hsa-miR-378c WDR31 -1.8 0 -0.52 0.0008 MirTarget -0.13 0.00047 NA
142 hsa-miR-378a-3p ZKSCAN1 -1.8 0 -0.3 0.01748 MirTarget -0.16 0 NA
143 hsa-miR-378a-3p ZNF100 -1.8 0 0.13 0.14768 miRNAWalker2 validate -0.11 0 NA
144 hsa-miR-378a-3p ZNF182 -1.8 0 0 0.96629 miRNATAP -0.15 0 NA
145 hsa-miR-378c ZNF182 -1.8 0 0 0.96629 miRNATAP -0.13 0 NA
146 hsa-miR-378a-3p ZNF239 -1.8 0 1.14 0 miRNAWalker2 validate -0.3 0 NA
147 hsa-miR-378a-3p ZNF500 -1.8 0 0.37 0 mirMAP -0.15 0 NA
148 hsa-miR-378c ZNF500 -1.8 0 0.37 0 mirMAP -0.16 0 NA

Over-represented Gene Ontology Biological Process

NumGOOverlapSizeP ValueAdj. P Value
NumGOOverlapSizeP ValueAdj. P Value
NumGOOverlapSizeP ValueAdj. P Value

Over-represented Pathway

NumPathwayPathviewOverlapSizeP ValueAdj. P Value
1 Signaling_pathways_regulating_pluripotency_of_stem_cells_hsa04550 4 139 0.007309 0.38
2 Hedgehog_signaling_pathway_hsa04340 2 47 0.02759 0.7174
3 Adherens_junction_hsa04520 2 72 0.05974 0.8318
4 HIF_1_signaling_pathway_hsa04066 2 100 0.105 0.8318
5 Ras_signaling_pathway_hsa04014 3 232 0.136 0.8318
6 AMPK_signaling_pathway_hsa04152 2 121 0.1432 0.8318
7 Cell_cycle_hsa04110 2 124 0.1489 0.8318
8 Endocytosis_hsa04144 3 244 0.1513 0.8318
9 FoxO_signaling_pathway_hsa04068 2 132 0.1643 0.8318
10 Wnt_signaling_pathway_hsa04310 2 146 0.1918 0.8318
11 mTOR_signaling_pathway_hsa04150 2 151 0.2018 0.8318
12 Cellular_senescence_hsa04218 2 160 0.2199 0.8318
13 MAPK_signaling_pathway_hsa04010 3 295 0.2215 0.8318
14 Jak_STAT_signaling_pathway_hsa04630 2 162 0.2239 0.8318
15 Focal_adhesion_hsa04510 2 199 0.2992 0.9587
16 PI3K_Akt_signaling_pathway_hsa04151 3 352 0.3058 0.9587
17 Rap1_signaling_pathway_hsa04015 2 206 0.3134 0.9587
18 Neuroactive_ligand_receptor_interaction_hsa04080 2 278 0.4535 1

Quest ID: b7504da78cfd8d48b27e24d68fdfe862