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This regulatory network was inferred from the input dataset. The miRNAs and mRNAs are presented as round and rectangle nodes respectively. The numerical value popped up upon mouse over the gene node is the log2 transformed fold-change of the gene expression between the two groups. All of the nodes are clickable, and the detailed information of the miRNAs/mRNAs and related cancer pathway will be displayed in another window. The edges between nodes are supported by both interactions (predicted or experimentally verified) and correlations learnt from cancer dataset. The numerical value popped up upon mouse over the edge is the correlation beat value (effect size) between the two nodes. The experimental evidences of the edges reported in previous cancer studies are highlighted by red/orange color. All of these information can be accessed by the "mouse-over" action. This network shows a full map of the miRNA-mRNA regulation of the input gene list(s), and the hub miRNAs (with the high network degree/betweenness centrality) would be the potential cancer drivers or tumor suppressors. The full result table can be accessed in the "Regulations" tab.

"miRNACancerMAP" is also a network visualization tool for users to draw their regulatory network by personal customization. Users can set the complexity of the network by limiting the number of nodes or edges. And the color of the nodes can be defined by different categories of the mRNAs and miRNAs, such as Gene-Ontology, pathway, and expression status. Users can also select to use network degree or network betweenness centrality to define the node size. And edges can be black or colored by the correlation. Purple edge means negative correlation (mostly found between miRNA and mRNA), and blue edge means positive correlation (found in PPI or miRNA-miRNA sponge effect). We can also add the protein-protein interactions (PPI) into the network. This result will show the cluster of genes regulated by some specific miRNAs. Additionally, miRNA-miRNA edges can be added by the "miRNA sponge" button, presenting some clusters of miRNAs that have the interactions via sponge effect.

miRNA-gene regulations

(Download full result)

Num microRNA           Gene miRNA log2FC miRNA pvalue Gene log2FC Gene pvalue Interaction Correlation beta Correlation P-value PMID Reported in cancer studies
1 hsa-miR-106b-5p TGFBR2 0.65 0 -0.52 3.0E-5 miRNATAP -0.37 0 NA
2 hsa-miR-130b-3p TGFBR2 0.69 0.00011 -0.52 3.0E-5 miRNAWalker2 validate; miRNATAP -0.13 0.00014 25024357 Follow-up experiments showed two miRNAs miR-9-5p and miR-130b-3p in this module had increased expression while their target gene TGFBR2 had decreased expression in a cohort of human NSCLC
3 hsa-miR-17-5p TGFBR2 0.7 2.0E-5 -0.52 3.0E-5 miRNAWalker2 validate; miRTarBase; TargetScan; miRNATAP -0.2 0 25011053; 27120811 We demonstrate that miR-17 overexpression interferes with the TGFβ-EMT axis and hinders RCC sphere formation; and validated TGFBR2 as a direct and biologically relevant target during this process;MiR-17-5p was found to bind to the 3'UTR of TGFBR2 mRNA and further validation of this specific binding was performed through a reporter assay; An inverse correlation between miR-17-5p and TGFBR2 protein was observed in gastric cancer tissues; Cell studies revealed that miR-17-5p negatively regulated TGFBR2 expression by directly binding to the 3'UTR of TGFBR2 mRNA thereby promoting cell growth and migration; The results of our study suggest a novel regulatory network in gastric cancer mediated by miR-17-5p and TGFBR2 and may indicate that TGFBR2 could serve as a new therapeutic target in gastric cancer
4 hsa-miR-18a-5p TGFBR2 0.92 2.0E-5 -0.52 3.0E-5 miRNAWalker2 validate -0.19 0 NA
5 hsa-miR-19a-3p TGFBR2 1.02 0 -0.52 3.0E-5 miRNAWalker2 validate; miRNATAP -0.15 0 NA
6 hsa-miR-19b-3p TGFBR2 0.6 0.00017 -0.52 3.0E-5 miRNAWalker2 validate; miRNATAP -0.16 3.0E-5 NA
7 hsa-miR-20a-5p TGFBR2 0.85 0 -0.52 3.0E-5 miRNAWalker2 validate; miRTarBase; miRNATAP -0.18 0 NA
8 hsa-miR-21-5p TGFBR2 1.51 0 -0.52 3.0E-5 miRNAWalker2 validate; miRTarBase; miRNATAP -0.24 0 24037531 Androgen receptor and microRNA 21 axis downregulates transforming growth factor beta receptor II TGFBR2 expression in prostate cancer; Our results revealed that miR-21 suppresses TGFBR2 levels by binding to its 3'-UTR and AR signaling further potentiates this effect in both untransformed and transformed human prostate epithelial cells as well as in human prostate cancers; Manipulation of androgen signaling or the expression levels of AR or miR-21 negatively altered TGFBR2 expression in untransformed and transformed human prostate epithelial cells human prostate cancer xenografts and mouse prostate glands; Together these results suggest that the AR and miR-21 axis exerts its oncogenic effects in prostate tumors by downregulating TGFBR2 hence inhibiting the tumor-suppressive activity of TGFβ pathway
9 hsa-miR-301a-3p TGFBR2 0.84 0 -0.52 3.0E-5 miRNATAP -0.18 0 25551793 MicroRNA 301a promotes migration and invasion by targeting TGFBR2 in human colorectal cancer; TGFBR2 was identified to be the downstream target of miR-301a; Knockdown of TGFBR2 in cells treated by miR-301a inhibitor elevated the previously abrogated migration and invasion; Our data indicated that miR-301a correlated with the metastatic and invasive ability in human colorectal cancers and miR-301a exerted its role as oncogene by targeting TGFBR2
10 hsa-miR-501-3p TGFBR2 1 0 -0.52 3.0E-5 TargetScan -0.12 0.00378 NA
11 hsa-miR-590-5p TGFBR2 -0.1 0.31003 -0.52 3.0E-5 miRNAWalker2 validate; miRTarBase; PITA; miRanda; miRNATAP -0.25 4.0E-5 NA
12 hsa-miR-92a-3p TGFBR2 0.21 0.13429 -0.52 3.0E-5 miRNAWalker2 validate -0.17 7.0E-5 NA
13 hsa-miR-93-5p TGFBR2 1.4 0 -0.52 3.0E-5 miRNAWalker2 validate; miRNATAP -0.26 0 NA

Over-represented Gene Ontology Biological Process

NumGOOverlapSizeP ValueAdj. P Value
1 REGULATION OF CELL CYCLE 27 949 1.39e-15 6.466e-12
2 CELL CYCLE 30 1316 9.049e-15 2.105e-11
3 CELL CYCLE PHASE TRANSITION 15 255 2.464e-13 3.821e-10
4 REGULATION OF CELL DEATH 29 1472 1.168e-12 1.359e-09
5 REGULATION OF TRANSFERASE ACTIVITY 23 946 7.034e-12 6.546e-09
6 CELL CYCLE PROCESS 24 1081 1.491e-11 1.156e-08
7 CELL CYCLE G2 M PHASE TRANSITION 11 138 1.775e-11 1.18e-08
8 MITOTIC CELL CYCLE 20 766 6.101e-11 3.548e-08
9 CELL DEATH 22 1001 1.545e-10 7.989e-08
10 TRANSFORMING GROWTH FACTOR BETA RECEPTOR SIGNALING PATHWAY 9 95 2.846e-10 1.324e-07
11 POSITIVE REGULATION OF DNA METABOLIC PROCESS 11 185 4.215e-10 1.621e-07
12 NEGATIVE REGULATION OF CELL CYCLE 15 433 4.528e-10 1.621e-07
13 REGULATION OF PHOSPHORUS METABOLIC PROCESS 27 1618 3.884e-10 1.621e-07
14 REGULATION OF KINASE ACTIVITY 19 776 5.856e-10 1.946e-07
15 POSITIVE REGULATION OF TRANSFERASE ACTIVITY 17 616 8.961e-10 2.633e-07
16 REGULATION OF CELL CYCLE ARREST 9 108 9.054e-10 2.633e-07
17 CELLULAR RESPONSE TO STRESS 26 1565 1.003e-09 2.745e-07
18 REGULATION OF PROTEIN MODIFICATION PROCESS 27 1710 1.319e-09 3.409e-07
19 REGULATION OF CELL CYCLE PROCESS 16 558 1.732e-09 4.242e-07
20 POSITIVE REGULATION OF RESPONSE TO STIMULUS 28 1929 3.893e-09 8.627e-07
21 SIGNAL TRANSDUCTION BY P53 CLASS MEDIATOR 9 127 3.84e-09 8.627e-07
22 REGULATION OF CELLULAR RESPONSE TO STRESS 17 691 5.039e-09 1.066e-06
23 PHOSPHORYLATION 22 1228 6.981e-09 1.412e-06
24 POSITIVE REGULATION OF CELL CYCLE PROCESS 11 247 8.83e-09 1.643e-06
25 MITOTIC CELL CYCLE CHECKPOINT 9 139 8.516e-09 1.643e-06
26 CELL DIVISION 14 460 9.537e-09 1.644e-06
27 RESPONSE TO ABIOTIC STIMULUS 20 1024 9.305e-09 1.644e-06
28 CELL CYCLE CHECKPOINT 10 194 1.092e-08 1.815e-06
29 RESPONSE TO TRANSFORMING GROWTH FACTOR BETA 9 144 1.161e-08 1.863e-06
30 ERROR FREE TRANSLESION SYNTHESIS 5 19 1.449e-08 2.107e-06
31 NEGATIVE REGULATION OF MITOTIC CELL CYCLE 10 199 1.393e-08 2.107e-06
32 ERROR PRONE TRANSLESION SYNTHESIS 5 19 1.449e-08 2.107e-06
33 POSITIVE REGULATION OF CELL CYCLE 12 332 1.829e-08 2.579e-06
34 REGULATION OF DNA METABOLIC PROCESS 12 340 2.379e-08 3.255e-06
35 NEGATIVE REGULATION OF PROTEIN METABOLIC PROCESS 20 1087 2.525e-08 3.356e-06
36 PHOSPHATE CONTAINING COMPOUND METABOLIC PROCESS 27 1977 2.981e-08 3.853e-06
37 CELLULAR RESPONSE TO ORGANIC SUBSTANCE 26 1848 3.223e-08 4.053e-06
38 POSITIVE REGULATION OF CELL DEATH 15 605 4.094e-08 4.884e-06
39 MEMBRANE ORGANIZATION 18 899 4.029e-08 4.884e-06
40 REGULATION OF PROTEIN BINDING 9 168 4.439e-08 5.164e-06
41 MEMBRANE DISASSEMBLY 6 47 4.937e-08 5.292e-06
42 NUCLEOTIDE EXCISION REPAIR DNA GAP FILLING 5 24 5.208e-08 5.292e-06
43 DNA BIOSYNTHETIC PROCESS 8 121 5.085e-08 5.292e-06
44 NUCLEAR ENVELOPE DISASSEMBLY 6 47 4.937e-08 5.292e-06
45 REGULATION OF PROTEOLYSIS 16 711 5.231e-08 5.292e-06
46 NEGATIVE REGULATION OF PROTEIN MODIFICATION PROCESS 15 616 5.183e-08 5.292e-06
47 NUCLEAR ENVELOPE ORGANIZATION 7 81 5.7e-08 5.643e-06
48 CELLULAR RESPONSE TO DNA DAMAGE STIMULUS 16 720 6.219e-08 6.029e-06
49 POSITIVE REGULATION OF CATALYTIC ACTIVITY 23 1518 6.662e-08 6.326e-06
50 REGULATION OF INTRACELLULAR SIGNAL TRANSDUCTION 24 1656 7.379e-08 6.867e-06
51 REGULATION OF CATABOLIC PROCESS 16 731 7.657e-08 6.985e-06
52 PROTEIN LOCALIZATION 25 1805 8.781e-08 7.857e-06
53 REGULATION OF MITOTIC CELL CYCLE 13 468 9.831e-08 8.63e-06
54 PROTEIN LOCALIZATION TO ORGANELLE 14 556 1.01e-07 8.705e-06
55 NUCLEUS ORGANIZATION 8 136 1.262e-07 1.042e-05
56 TRANSMEMBRANE RECEPTOR PROTEIN SERINE THREONINE KINASE SIGNALING PATHWAY 9 190 1.277e-07 1.042e-05
57 DNA METABOLIC PROCESS 16 758 1.256e-07 1.042e-05
58 REGULATION OF RESPONSE TO STRESS 22 1468 1.679e-07 1.347e-05
59 SIGNAL TRANSDUCTION IN RESPONSE TO DNA DAMAGE 7 96 1.855e-07 1.463e-05
60 NEGATIVE REGULATION OF CELL CYCLE G1 S PHASE TRANSITION 7 98 2.138e-07 1.658e-05
61 NEGATIVE REGULATION OF CELL CYCLE PHASE TRANSITION 8 146 2.183e-07 1.665e-05
62 POSITIVE REGULATION OF PROTEIN METABOLIC PROCESS 22 1492 2.223e-07 1.669e-05
63 POSITIVE REGULATION OF PROTEIN MODIFICATION PROCESS 19 1135 2.631e-07 1.943e-05
64 RESPONSE TO ORGANIC CYCLIC COMPOUND 17 917 3.041e-07 2.211e-05
65 POSITIVE REGULATION OF MOLECULAR FUNCTION 24 1791 3.177e-07 2.274e-05
66 POSITIVE REGULATION OF PHOSPHATE METABOLIC PROCESS 18 1036 3.349e-07 2.326e-05
67 POSITIVE REGULATION OF PHOSPHORUS METABOLIC PROCESS 18 1036 3.349e-07 2.326e-05
68 NEGATIVE REGULATION OF CELL CYCLE PROCESS 9 214 3.502e-07 2.397e-05
69 POSITIVE REGULATION OF BIOSYNTHETIC PROCESS 24 1805 3.665e-07 2.472e-05
70 DNA DAMAGE RESPONSE DETECTION OF DNA DAMAGE 5 36 4.436e-07 2.949e-05
71 PROTEIN PHOSPHORYLATION 17 944 4.567e-07 2.982e-05
72 REGULATION OF DNA REPLICATION 8 161 4.615e-07 2.982e-05
73 RESPONSE TO ENDOGENOUS STIMULUS 21 1450 6.028e-07 3.842e-05
74 NUCLEOTIDE EXCISION REPAIR DNA INCISION 5 39 6.707e-07 4.217e-05
75 G1 DNA DAMAGE CHECKPOINT 6 73 7.16e-07 4.442e-05
76 DNA SYNTHESIS INVOLVED IN DNA REPAIR 6 74 7.765e-07 4.717e-05
77 REGULATION OF PROTEIN SERINE THREONINE KINASE ACTIVITY 12 470 7.806e-07 4.717e-05
78 TRANSLESION SYNTHESIS 5 41 8.671e-07 5.172e-05
79 CELLULAR MACROMOLECULE LOCALIZATION 19 1234 9.375e-07 5.522e-05
80 NEGATIVE REGULATION OF GENE EXPRESSION 21 1493 9.703e-07 5.644e-05
81 POSITIVE REGULATION OF KINASE ACTIVITY 12 482 1.017e-06 5.843e-05
82 REGULATION OF CELL CYCLE PHASE TRANSITION 10 321 1.187e-06 6.738e-05
83 REGULATION OF RELEASE OF CYTOCHROME C FROM MITOCHONDRIA 5 44 1.244e-06 6.973e-05
84 ENZYME LINKED RECEPTOR PROTEIN SIGNALING PATHWAY 14 689 1.331e-06 7.375e-05
85 POSITIVE REGULATION OF CELL COMMUNICATION 21 1532 1.471e-06 8.054e-05
86 REGULATION OF CELLULAR LOCALIZATION 19 1277 1.564e-06 8.461e-05
87 POSITIVE REGULATION OF CELL CYCLE ARREST 6 85 1.765e-06 9.441e-05
88 ESTABLISHMENT OF PROTEIN LOCALIZATION 20 1423 1.892e-06 0.0001001
89 POSITIVE REGULATION OF PROTEIN MODIFICATION BY SMALL PROTEIN CONJUGATION OR REMOVAL 8 196 2.036e-06 0.0001064
90 RESPONSE TO DRUG 11 431 2.348e-06 0.0001214
91 NEGATIVE REGULATION OF MOLECULAR FUNCTION 17 1079 2.857e-06 0.0001461
92 DNA INTEGRITY CHECKPOINT 7 146 3.174e-06 0.0001605
93 REGULATION OF PROTEIN MODIFICATION BY SMALL PROTEIN CONJUGATION OR REMOVAL 9 280 3.258e-06 0.000163
94 REGULATION OF CELL CYCLE G1 S PHASE TRANSITION 7 147 3.321e-06 0.0001644
95 POSTREPLICATION REPAIR 5 54 3.502e-06 0.000166
96 MITOTIC NUCLEAR DIVISION 10 361 3.397e-06 0.000166
97 POSITIVE REGULATION OF PROTEOLYSIS 10 363 3.568e-06 0.000166
98 REGULATION OF BINDING 9 283 3.554e-06 0.000166
99 RESPONSE TO ALCOHOL 10 362 3.481e-06 0.000166
100 REGULATION OF APOPTOTIC SIGNALING PATHWAY 10 363 3.568e-06 0.000166
101 NEGATIVE REGULATION OF CELL DEATH 15 872 4.179e-06 0.0001925
102 MITOTIC DNA INTEGRITY CHECKPOINT 6 100 4.57e-06 0.0002085
103 REGULATION OF MAPK CASCADE 13 660 4.649e-06 0.00021
104 CELLULAR GLUCAN METABOLIC PROCESS 5 58 5.006e-06 0.0002218
105 GLUCAN METABOLIC PROCESS 5 58 5.006e-06 0.0002218
106 REGULATION OF PROTEIN UBIQUITINATION INVOLVED IN UBIQUITIN DEPENDENT PROTEIN CATABOLIC PROCESS 6 103 5.426e-06 0.0002382
107 ESTABLISHMENT OF PROTEIN LOCALIZATION TO ENDOPLASMIC RETICULUM 6 104 5.739e-06 0.0002496
108 REGENERATION 7 161 6.059e-06 0.0002587
109 POSITIVE REGULATION OF ORGANELLE ORGANIZATION 12 573 6.044e-06 0.0002587
110 DNA REPAIR 11 480 6.56e-06 0.0002775
111 POSITIVE REGULATION OF CATABOLIC PROCESS 10 395 7.505e-06 0.0003146
112 POSITIVE REGULATION OF LIGASE ACTIVITY 6 110 7.936e-06 0.0003297
113 CELL CYCLE G1 S PHASE TRANSITION 6 111 8.36e-06 0.0003412
114 G1 S TRANSITION OF MITOTIC CELL CYCLE 6 111 8.36e-06 0.0003412
115 INTRACELLULAR SIGNAL TRANSDUCTION 20 1572 8.539e-06 0.0003455
116 MACROMOLECULE CATABOLIC PROCESS 15 926 8.613e-06 0.0003455
117 MISMATCH REPAIR 4 31 9.175e-06 0.0003619
118 REGULATION OF ORGANELLE ORGANIZATION 17 1178 9.177e-06 0.0003619
119 POSITIVE REGULATION OF GENE EXPRESSION 21 1733 1.022e-05 0.0003994
120 NEGATIVE REGULATION OF CELL COMMUNICATION 17 1192 1.071e-05 0.0004153
121 NUCLEAR TRANSCRIBED MRNA CATABOLIC PROCESS NONSENSE MEDIATED DECAY 6 118 1.188e-05 0.0004568
122 MICROTUBULE BASED PROCESS 11 522 1.44e-05 0.0005446
123 CELLULAR RESPONSE TO TOPOLOGICALLY INCORRECT PROTEIN 6 122 1.437e-05 0.0005446
124 ENERGY RESERVE METABOLIC PROCESS 5 72 1.458e-05 0.0005472
125 POSITIVE REGULATION OF MITOTIC CELL CYCLE 6 123 1.506e-05 0.0005561
126 PROTEIN LOCALIZATION TO ENDOPLASMIC RETICULUM 6 123 1.506e-05 0.0005561
127 TRANSCRIPTION COUPLED NUCLEOTIDE EXCISION REPAIR 5 73 1.56e-05 0.0005716
128 POSITIVE REGULATION OF PROTEIN CATABOLIC PROCESS 8 263 1.76e-05 0.0006397
129 AGING 8 264 1.808e-05 0.0006472
130 ESTABLISHMENT OF PROTEIN LOCALIZATION TO MEMBRANE 8 264 1.808e-05 0.0006472
131 MICROTUBULE CYTOSKELETON ORGANIZATION 9 348 1.867e-05 0.0006631
132 POSITIVE REGULATION OF CELLULAR PROTEIN CATABOLIC PROCESS 7 192 1.908e-05 0.0006707
133 RESPONSE TO OXYGEN CONTAINING COMPOUND 18 1381 1.917e-05 0.0006707
134 WNT SIGNALING PATHWAY 9 351 1.998e-05 0.0006858
135 NEGATIVE REGULATION OF PHOSPHORUS METABOLIC PROCESS 11 541 2.004e-05 0.0006858
136 NEGATIVE REGULATION OF PHOSPHATE METABOLIC PROCESS 11 541 2.004e-05 0.0006858
137 ANAPHASE PROMOTING COMPLEX DEPENDENT CATABOLIC PROCESS 5 77 2.025e-05 0.0006877
138 REGULATION OF LIGASE ACTIVITY 6 130 2.063e-05 0.0006957
139 VENTRICULAR CARDIAC MUSCLE CELL DEVELOPMENT 3 13 2.128e-05 0.0007124
140 ESTABLISHMENT OF LOCALIZATION IN CELL 20 1676 2.186e-05 0.0007213
141 PROTEASOMAL PROTEIN CATABOLIC PROCESS 8 271 2.182e-05 0.0007213
142 REGULATION OF CELLULAR PROTEIN CATABOLIC PROCESS 8 274 2.361e-05 0.0007736
143 POSITIVE REGULATION OF CELLULAR PROTEIN LOCALIZATION 9 360 2.438e-05 0.0007826
144 POLYSACCHARIDE METABOLIC PROCESS 5 80 2.439e-05 0.0007826
145 REGULATION OF CELLULAR PROTEIN LOCALIZATION 11 552 2.412e-05 0.0007826
146 ESTABLISHMENT OF PROTEIN LOCALIZATION TO ORGANELLE 9 361 2.492e-05 0.0007941
147 POSITIVE REGULATION OF EXTRINSIC APOPTOTIC SIGNALING PATHWAY IN ABSENCE OF LIGAND 3 14 2.7e-05 0.0008547
148 RESPONSE TO LIGHT STIMULUS 8 280 2.756e-05 0.0008665
149 INTRACELLULAR PROTEIN TRANSPORT 13 781 2.78e-05 0.000868
150 POSITIVE REGULATION OF CELLULAR COMPONENT ORGANIZATION 16 1152 2.807e-05 0.0008706
151 MULTI ORGANISM METABOLIC PROCESS 6 138 2.892e-05 0.0008913
152 ORGAN REGENERATION 5 83 2.916e-05 0.0008926
153 NEGATIVE REGULATION OF PROTEIN MODIFICATION BY SMALL PROTEIN CONJUGATION OR REMOVAL 6 139 3.013e-05 0.0009162
154 REGULATION OF HEART GROWTH 4 42 3.148e-05 0.0009512
155 REPRODUCTION 17 1297 3.175e-05 0.0009512
156 DNA REPLICATION 7 208 3.189e-05 0.0009512
157 POSITIVE REGULATION OF NUCLEASE ACTIVITY 3 15 3.365e-05 0.0009909
158 T CELL APOPTOTIC PROCESS 3 15 3.365e-05 0.0009909
159 POSITIVE REGULATION OF DNA REPLICATION 5 86 3.462e-05 0.001001
160 PROTEIN LOCALIZATION TO MEMBRANE 9 376 3.425e-05 0.001001
161 APOPTOTIC SIGNALING PATHWAY 8 289 3.451e-05 0.001001
162 CELLULAR RESPONSE TO OXYGEN LEVELS 6 143 3.534e-05 0.001015
163 GENERATION OF PRECURSOR METABOLITES AND ENERGY 8 292 3.714e-05 0.00106
164 RESPONSE TO INORGANIC SUBSTANCE 10 479 3.931e-05 0.001115
165 TRANSLATIONAL INITIATION 6 146 3.971e-05 0.00112
166 REGULATION OF CYTOPLASMIC TRANSPORT 10 481 4.072e-05 0.001141
167 PROTEIN LOCALIZATION TO CHROMOSOME 4 45 4.15e-05 0.001156
168 ENERGY DERIVATION BY OXIDATION OF ORGANIC COMPOUNDS 7 217 4.177e-05 0.001157
169 REGULATION OF MITOCHONDRION ORGANIZATION 7 218 4.3e-05 0.00117
170 RHYTHMIC PROCESS 8 298 4.288e-05 0.00117
171 REGULATION OF PROTEIN LOCALIZATION TO NUCLEUS 7 218 4.3e-05 0.00117
172 REGULATION OF EXTRINSIC APOPTOTIC SIGNALING PATHWAY IN ABSENCE OF LIGAND 4 46 4.53e-05 0.001226
173 REGULATION OF PROTEIN STABILITY 7 221 4.69e-05 0.001261
174 REGULATION OF PROTEIN CATABOLIC PROCESS 9 393 4.827e-05 0.001291
175 REGULATION OF EXTRINSIC APOPTOTIC SIGNALING PATHWAY 6 153 5.159e-05 0.001364
176 NEGATIVE REGULATION OF CATALYTIC ACTIVITY 13 829 5.141e-05 0.001364
177 ORGANELLE FISSION 10 496 5.269e-05 0.001385
178 REGULATION OF CARDIAC MUSCLE TISSUE DEVELOPMENT 4 48 5.367e-05 0.001403
179 CYTOSKELETON ORGANIZATION 13 838 5.739e-05 0.001489
180 RESPONSE TO OXYGEN LEVELS 8 311 5.791e-05 0.001489
181 NEGATIVE REGULATION OF RESPONSE TO STIMULUS 17 1360 5.761e-05 0.001489
182 PROTEIN TARGETING TO MEMBRANE 6 157 5.957e-05 0.00152
183 LYMPHOCYTE APOPTOTIC PROCESS 3 18 5.978e-05 0.00152
184 LYMPHOCYTE HOMEOSTASIS 4 50 6.311e-05 0.001596
185 RESPONSE TO ENDOPLASMIC RETICULUM STRESS 7 233 6.547e-05 0.001647
186 NEGATIVE REGULATION OF NITROGEN COMPOUND METABOLIC PROCESS 18 1517 6.613e-05 0.001654
187 REGULATION OF MAP KINASE ACTIVITY 8 319 6.918e-05 0.001721
188 VENTRICULAR CARDIAC MUSCLE CELL DIFFERENTIATION 3 19 7.077e-05 0.001736
189 RESPONSE TO RADIATION 9 413 7.07e-05 0.001736
190 REGULATION OF SIGNAL TRANSDUCTION BY P53 CLASS MEDIATOR 6 162 7.089e-05 0.001736
191 RESPONSE TO TOPOLOGICALLY INCORRECT PROTEIN 6 163 7.335e-05 0.001787
192 POSITIVE REGULATION OF EXTRINSIC APOPTOTIC SIGNALING PATHWAY 4 53 7.946e-05 0.001926
193 RESPONSE TO TOXIC SUBSTANCE 7 241 8.091e-05 0.001951
194 NEGATIVE REGULATION OF PHOSPHORYLATION 9 422 8.335e-05 0.001999
195 POSITIVE REGULATION OF INTRACELLULAR SIGNAL TRANSDUCTION 13 876 8.99e-05 0.002145
196 RESPONSE TO METAL ION 8 333 9.326e-05 0.002214
197 POSITIVE REGULATION OF APOPTOTIC SIGNALING PATHWAY 6 171 9.557e-05 0.002257
198 CHROMOSOME ORGANIZATION 14 1009 9.611e-05 0.002259
199 REGULATION OF PROTEIN HOMODIMERIZATION ACTIVITY 3 22 0.0001114 0.002592
200 RELEASE OF CYTOCHROME C FROM MITOCHONDRIA 3 22 0.0001114 0.002592
201 NUCLEIC ACID PHOSPHODIESTER BOND HYDROLYSIS 7 254 0.0001123 0.002599
202 SINGLE ORGANISM CELLULAR LOCALIZATION 13 898 0.0001152 0.002654
203 POSITIVE REGULATION OF DNA BIOSYNTHETIC PROCESS 4 59 0.0001211 0.002776
204 REGULATION OF NUCLEASE ACTIVITY 3 23 0.0001277 0.002885
205 NUCLEOTIDE EXCISION REPAIR 5 113 0.0001274 0.002885
206 LEUKOCYTE APOPTOTIC PROCESS 3 23 0.0001277 0.002885
207 LEUKOCYTE HOMEOSTASIS 4 60 0.0001293 0.002907
208 NOTCH SIGNALING PATHWAY 5 114 0.0001328 0.002972
209 NEGATIVE REGULATION OF TRANSFERASE ACTIVITY 8 351 0.0001341 0.002985
210 CELLULAR CATABOLIC PROCESS 16 1322 0.0001435 0.003179
211 PROTEIN MATURATION 7 265 0.0001459 0.003218
212 REGULATION OF HYDROLASE ACTIVITY 16 1327 0.0001499 0.003274
213 RESPONSE TO WOUNDING 10 563 0.0001498 0.003274
214 GLYCOGEN BIOSYNTHETIC PROCESS 3 25 0.0001649 0.003552
215 EPITHELIAL CELL APOPTOTIC PROCESS 3 25 0.0001649 0.003552
216 GLUCAN BIOSYNTHETIC PROCESS 3 25 0.0001649 0.003552
217 ENDOMEMBRANE SYSTEM ORGANIZATION 9 465 0.0001732 0.003715
218 HEART DEVELOPMENT 9 466 0.000176 0.003757
219 FEMALE MEIOTIC DIVISION 3 26 0.0001858 0.003948
220 CELLULAR RESPONSE TO UV 4 66 0.0001874 0.00395
221 POSITIVE REGULATION OF MAPK CASCADE 9 470 0.0001876 0.00395
222 CELL AGING 4 67 0.0001987 0.004164
223 REGULATION OF PROTEIN LOCALIZATION 13 950 0.0002009 0.004192
224 RESPONSE TO GROWTH FACTOR 9 475 0.000203 0.004216
225 REGULATION OF STRESS ACTIVATED PROTEIN KINASE SIGNALING CASCADE 6 197 0.0002069 0.004278
226 REGULATION OF TRANSCRIPTION INVOLVED IN G1 S TRANSITION OF MITOTIC CELL CYCLE 3 27 0.0002084 0.00429
227 MULTI ORGANISM TRANSPORT 4 68 0.0002104 0.004294
228 MULTI ORGANISM LOCALIZATION 4 68 0.0002104 0.004294
229 REGULATION OF G PROTEIN COUPLED RECEPTOR PROTEIN SIGNALING PATHWAY 5 127 0.0002202 0.004455
230 TISSUE DEVELOPMENT 17 1518 0.0002194 0.004455
231 RESPONSE TO COPPER ION 3 28 0.0002327 0.004666
232 POSITIVE REGULATION OF RELEASE OF CYTOCHROME C FROM MITOCHONDRIA 3 28 0.0002327 0.004666
233 POSITIVE REGULATION OF PROTEIN LOCALIZATION TO NUCLEUS 5 129 0.0002368 0.004729
234 PEPTIDYL AMINO ACID MODIFICATION 12 841 0.000247 0.004911
235 POSITIVE REGULATION OF PROTEIN SERINE THREONINE KINASE ACTIVITY 7 289 0.0002481 0.004913
236 VIRAL LIFE CYCLE 7 290 0.0002534 0.004996
237 REGULATION OF CARDIAC MUSCLE CELL PROLIFERATION 3 29 0.0002587 0.005079
238 REGULATION OF TRANSMEMBRANE RECEPTOR PROTEIN SERINE THREONINE KINASE SIGNALING PATHWAY 6 207 0.0002701 0.005258
239 POSITIVE REGULATION OF MAP KINASE ACTIVITY 6 207 0.0002701 0.005258
240 MACROMOLECULAR COMPLEX ASSEMBLY 16 1398 0.0002714 0.005262
241 POSITIVE REGULATION OF PROTEIN BINDING 4 73 0.0002767 0.005319
242 REGULATION OF ORGAN GROWTH 4 73 0.0002767 0.005319
243 PROTEIN UBIQUITINATION INVOLVED IN UBIQUITIN DEPENDENT PROTEIN CATABOLIC PROCESS 5 134 0.0002825 0.005409
244 DNA STRAND ELONGATION 3 30 0.0002866 0.005465
245 CARDIAC MUSCLE CELL DIFFERENTIATION 4 74 0.0002915 0.005519
246 RESPONSE TO MECHANICAL STIMULUS 6 210 0.0002918 0.005519
247 CELLULAR RESPONSE TO RADIATION 5 137 0.0003129 0.005894
248 REGULATION OF CYSTEINE TYPE ENDOPEPTIDASE ACTIVITY 6 213 0.0003148 0.005906
249 REGULATION OF INTRACELLULAR TRANSPORT 10 621 0.0003286 0.006141
250 PROTEIN MODIFICATION BY SMALL PROTEIN CONJUGATION OR REMOVAL 12 873 0.0003468 0.006399
251 PATTERNING OF BLOOD VESSELS 3 32 0.0003479 0.006399
252 TELOMERE MAINTENANCE VIA RECOMBINATION 3 32 0.0003479 0.006399
253 CARDIAC MUSCLE TISSUE DEVELOPMENT 5 140 0.0003458 0.006399
254 CELLULAR RESPONSE TO ENDOGENOUS STIMULUS 13 1008 0.0003565 0.006531
255 PROTEIN TARGETING 8 406 0.000359 0.00655
256 REGULATION OF WNT SIGNALING PATHWAY 7 310 0.000379 0.006854
257 SIGNAL TRANSDUCTION IN ABSENCE OF LIGAND 3 33 0.0003815 0.006854
258 EXTRINSIC APOPTOTIC SIGNALING PATHWAY IN ABSENCE OF LIGAND 3 33 0.0003815 0.006854
259 REGULATION OF CELL AGING 3 33 0.0003815 0.006854
260 CELLULAR CARBOHYDRATE METABOLIC PROCESS 5 144 0.0003935 0.007043
261 RESPONSE TO LIPID 12 888 0.0004044 0.007209
262 T CELL HOMEOSTASIS 3 34 0.0004172 0.007408
263 RNA CATABOLIC PROCESS 6 227 0.0004416 0.007813
264 PEPTIDYL SERINE MODIFICATION 5 148 0.0004462 0.007834
265 RESPONSE TO TRANSITION METAL NANOPARTICLE 5 148 0.0004462 0.007834
266 NIK NF KAPPAB SIGNALING 4 83 0.0004521 0.007897
267 REGULATION OF GLYCOGEN METABOLIC PROCESS 3 35 0.0004548 0.007897
268 NEURON APOPTOTIC PROCESS 3 35 0.0004548 0.007897
269 EPHRIN RECEPTOR SIGNALING PATHWAY 4 85 0.0004949 0.008529
270 POSITIVE REGULATION OF MITOCHONDRIAL OUTER MEMBRANE PERMEABILIZATION INVOLVED IN APOPTOTIC SIGNALING PATHWAY 3 36 0.0004947 0.008529
271 INTRINSIC APOPTOTIC SIGNALING PATHWAY 5 152 0.0005039 0.008652
272 REGULATION OF I KAPPAB KINASE NF KAPPAB SIGNALING 6 233 0.0005069 0.008671
273 INTERSPECIES INTERACTION BETWEEN ORGANISMS 10 662 0.0005424 0.009177
274 ORGANONITROGEN COMPOUND METABOLIC PROCESS 18 1796 0.0005398 0.009177
275 SYMBIOSIS ENCOMPASSING MUTUALISM THROUGH PARASITISM 10 662 0.0005424 0.009177
276 CARDIOVASCULAR SYSTEM DEVELOPMENT 11 788 0.0005482 0.009209
277 CIRCULATORY SYSTEM DEVELOPMENT 11 788 0.0005482 0.009209
278 POSITIVE REGULATION OF DNA REPAIR 3 38 0.0005808 0.009722
NumGOOverlapSizeP ValueAdj. P Value
1 ENZYME BINDING 29 1737 6.744e-11 6.265e-08
2 KINASE BINDING 16 606 5.614e-09 2.608e-06
3 CYCLIN DEPENDENT PROTEIN KINASE ACTIVITY 5 34 3.296e-07 0.0001021
4 KINASE ACTIVITY 15 842 2.727e-06 0.0006334
5 ADENYL NUCLEOTIDE BINDING 20 1514 4.865e-06 0.0007533
6 TRANSFERASE ACTIVITY TRANSFERRING PHOSPHORUS CONTAINING GROUPS 16 992 4.359e-06 0.0007533
7 PROTEIN COMPLEX BINDING 15 935 9.665e-06 0.001122
8 RIBONUCLEOTIDE BINDING 22 1860 8.74e-06 0.001122
9 TAU PROTEIN KINASE ACTIVITY 3 12 1.642e-05 0.001695
10 PROTEIN SERINE THREONINE KINASE ACTIVITY 10 445 2.104e-05 0.001926
11 MACROMOLECULAR COMPLEX BINDING 18 1399 2.28e-05 0.001926
NumGOOverlapSizeP ValueAdj. P Value
1 MICROTUBULE CYTOSKELETON 19 1068 1.025e-07 3.312e-05
2 CYTOSKELETON 26 1967 1.134e-07 3.312e-05
3 CHROMOSOME 16 880 9.243e-07 0.0001654
4 CENTROSOME 12 487 1.133e-06 0.0001654
5 RIBONUCLEOPROTEIN COMPLEX 14 721 2.265e-06 0.0002646
6 CYTOSOLIC PART 8 223 5.297e-06 0.0005156
7 CHROMOSOMAL REGION 9 330 1.225e-05 0.001022
8 MICROTUBULE ORGANIZING CENTER 12 623 1.4e-05 0.001022
9 PERINUCLEAR REGION OF CYTOPLASM 12 642 1.885e-05 0.001223
10 PROTEIN KINASE COMPLEX 5 90 4.311e-05 0.002518
11 NUCLEAR CHROMOSOME 10 523 8.187e-05 0.004347
12 CYTOSOLIC RIBOSOME 5 113 0.0001274 0.006202

Over-represented Pathway

NumPathwayPathviewOverlapSizeP ValueAdj. P Value
1 hsa04110_Cell_cycle 10 128 1.895e-10 3.355e-08
2 hsa03430_Mismatch_repair 5 23 4.137e-08 3.661e-06
3 hsa04114_Oocyte_meiosis 6 114 9.747e-06 0.0005235
4 hsa04115_p53_signaling_pathway 5 69 1.183e-05 0.0005235
5 hsa04914_Progesterone.mediated_oocyte_maturation 5 87 3.661e-05 0.001296
6 hsa03010_Ribosome 5 92 4.791e-05 0.001413
7 hsa04530_Tight_junction 5 133 0.0002728 0.006899
8 hsa03030_DNA_replication 3 36 0.0004947 0.01094
9 hsa04141_Protein_processing_in_endoplasmic_reticulum 5 168 0.0007929 0.01559
10 hsa03420_Nucleotide_excision_repair 3 45 0.0009561 0.01692
11 hsa04144_Endocytosis 5 203 0.001836 0.02954
12 hsa04910_Insulin_signaling_pathway 4 138 0.002976 0.04389
13 hsa04350_TGF.beta_signaling_pathway 3 85 0.005882 0.07587
14 hsa04010_MAPK_signaling_pathway 5 268 0.006001 0.07587
15 hsa04062_Chemokine_signaling_pathway 4 189 0.008986 0.1037
16 hsa03410_Base_excision_repair 2 34 0.009377 0.1037
17 hsa04330_Notch_signaling_pathway 2 47 0.01743 0.1717
18 hsa04722_Neurotrophin_signaling_pathway 3 127 0.01746 0.1717
19 hsa04621_NOD.like_receptor_signaling_pathway 2 59 0.02669 0.2486
20 hsa04720_Long.term_potentiation 2 70 0.03655 0.3081
21 hsa04730_Long.term_depression 2 70 0.03655 0.3081
22 hsa04520_Adherens_junction 2 73 0.03945 0.3174
23 hsa04510_Focal_adhesion 3 200 0.05515 0.4244
24 hsa04810_Regulation_of_actin_cytoskeleton 3 214 0.06485 0.4782
25 hsa04660_T_cell_receptor_signaling_pathway 2 108 0.07884 0.5582
26 hsa03040_Spliceosome 2 128 0.1051 0.6816
27 hsa04380_Osteoclast_differentiation 2 128 0.1051 0.6816
28 hsa04360_Axon_guidance 2 130 0.1078 0.6816
29 hsa04310_Wnt_signaling_pathway 2 151 0.1377 0.7944
30 hsa03013_RNA_transport 2 152 0.1391 0.7944
31 hsa04145_Phagosome 2 156 0.145 0.8022
32 hsa00230_Purine_metabolism 2 162 0.154 0.825

lncRNA-mediated sponge

(Download full result)

Num lncRNA miRNAs           miRNAs count     Gene Sponge regulatory network lncRNA log2FC lncRNA pvalue Gene log2FC Gene pvalue lncRNA-gene Pearson correlation
1 HCG11 hsa-miR-106b-5p;hsa-miR-130b-3p;hsa-miR-17-5p;hsa-miR-18a-5p;hsa-miR-19a-3p;hsa-miR-19b-3p;hsa-miR-20a-5p;hsa-miR-21-5p;hsa-miR-301a-3p;hsa-miR-93-5p 10 TGFBR2 Sponge network -0.781 0 -0.523 3.0E-5 0.472
2 MAGI2-AS3 hsa-miR-106b-5p;hsa-miR-130b-3p;hsa-miR-17-5p;hsa-miR-18a-5p;hsa-miR-19a-3p;hsa-miR-19b-3p;hsa-miR-20a-5p;hsa-miR-21-5p;hsa-miR-301a-3p;hsa-miR-92a-3p;hsa-miR-93-5p 11 TGFBR2 Sponge network -1.801 0 -0.523 3.0E-5 0.428
3 RP11-166D19.1 hsa-miR-106b-5p;hsa-miR-130b-3p;hsa-miR-17-5p;hsa-miR-18a-5p;hsa-miR-19a-3p;hsa-miR-19b-3p;hsa-miR-20a-5p;hsa-miR-21-5p;hsa-miR-301a-3p;hsa-miR-590-5p;hsa-miR-92a-3p 11 TGFBR2 Sponge network -0.244 0.28835 -0.523 3.0E-5 0.324

Quest ID: bf601cb56486913098b1d97e0813130c