Visible node/edge number:
Node colors:
Node labels:

show label of nodes with degree >=

Node sizes:
Edge colors:
Edge widths factor:
Layout:

gravity >=

edgeLength =

GRN in network:

Notice: IE browser need to manually refresh (F5) this page after resetting the network.

This regulatory network was inferred from the input dataset. The miRNAs and mRNAs are presented as round and rectangle nodes respectively. The numerical value popped up upon mouse over the gene node is the log2 transformed fold-change of the gene expression between the two groups. All of the nodes are clickable, and the detailed information of the miRNAs/mRNAs and related cancer pathway will be displayed in another window. The edges between nodes are supported by both interactions (predicted or experimentally verified) and correlations learnt from cancer dataset. The numerical value popped up upon mouse over the edge is the correlation beat value (effect size) between the two nodes. The experimental evidences of the edges reported in previous cancer studies are highlighted by red/orange color. All of these information can be accessed by the "mouse-over" action. This network shows a full map of the miRNA-mRNA regulation of the input gene list(s), and the hub miRNAs (with the high network degree/betweenness centrality) would be the potential cancer drivers or tumor suppressors. The full result table can be accessed in the "Regulations" tab.

"miRNACancerMAP" is also a network visualization tool for users to draw their regulatory network by personal customization. Users can set the complexity of the network by limiting the number of nodes or edges. And the color of the nodes can be defined by different categories of the mRNAs and miRNAs, such as Gene-Ontology, pathway, and expression status. Users can also select to use network degree or network betweenness centrality to define the node size. And edges can be black or colored by the correlation. Purple edge means negative correlation (mostly found between miRNA and mRNA), and blue edge means positive correlation (found in PPI or miRNA-miRNA sponge effect). We can also add the protein-protein interactions (PPI) into the network. This result will show the cluster of genes regulated by some specific miRNAs. Additionally, miRNA-miRNA edges can be added by the "miRNA sponge" button, presenting some clusters of miRNAs that have the interactions via sponge effect.

miRNA-gene regulations

(Download full result)

Num microRNA           Gene miRNA log2FC miRNA pvalue Gene log2FC Gene pvalue Interaction Correlation beta Correlation P-value PMID Reported in cancer studies
1 hsa-miR-200c-3p ACTC1 3.5 0 -7.19 0 MirTarget -1.34 0 NA
2 hsa-miR-200c-3p ADAMTS3 3.5 0 -1.18 0.00448 miRNATAP -0.41 0 NA
3 hsa-miR-200c-3p ADCY2 3.5 0 -3.87 0 MirTarget; miRNATAP -0.44 0 NA
4 hsa-miR-200c-3p AFF3 3.5 0 -5 0 MirTarget; miRNATAP -0.59 0 NA
5 hsa-miR-200c-3p AP1S2 3.5 0 -1.31 0 MirTarget; miRNATAP -0.38 0 NA
6 hsa-miR-200c-3p ARHGAP20 3.5 0 -3.52 0 MirTarget; miRNATAP -0.51 0 NA
7 hsa-miR-200c-5p ATP1A2 2.96 0 -6.96 0 MirTarget -0.88 0 NA
8 hsa-miR-200c-3p BACH2 3.5 0 -1.52 0.00134 mirMAP -0.54 0 NA
9 hsa-miR-200c-3p BEND4 3.5 0 -1.97 7.0E-5 mirMAP -0.32 0 NA
10 hsa-miR-200c-3p BNC2 3.5 0 -2.95 0 MirTarget -0.7 0 NA
11 hsa-miR-200c-3p C11orf87 3.5 0 -1.55 0.01186 miRNATAP -0.34 0 NA
12 hsa-miR-200c-3p CACNA1C 3.5 0 -2.53 0 MirTarget -0.44 0 NA
13 hsa-miR-200c-5p CACNB2 2.96 0 -2.97 0 MirTarget; miRNATAP -0.35 0 NA
14 hsa-miR-200c-5p CASQ2 2.96 0 -6.22 0 MirTarget -1.11 0 NA
15 hsa-miR-200c-5p CCDC141 2.96 0 -2.94 0 MirTarget -0.44 0 NA
16 hsa-miR-200c-3p CDK6 3.5 0 -0.77 0.06479 mirMAP -0.32 0 NA
17 hsa-miR-200c-3p CELF2 3.5 0 -3.05 0 mirMAP; miRNATAP -0.51 0 NA
18 hsa-miR-200c-5p CELF2 2.96 0 -3.05 0 miRNATAP -0.53 0 NA
19 hsa-miR-200c-3p CFL2 3.5 0 -2.62 0 MirTarget; miRNATAP -0.48 0 23497265 We characterized one of the target genes of miR-200c CFL2 and demonstrated that CFL2 is overexpressed in aggressive breast cancer cell lines and can be significantly down-regulated by exogenous miR-200c
20 hsa-miR-200c-3p CHRDL1 3.5 0 -6.15 0 MirTarget -0.99 0 NA
21 hsa-miR-200c-3p CHST11 3.5 0 0.54 0.2311 mirMAP -0.4 0 NA
22 hsa-miR-200c-3p CLIC4 3.5 0 -1.72 0 MirTarget; miRNATAP -0.46 0 NA
23 hsa-miR-200c-3p CNTFR 3.5 0 -3.86 0 miRNATAP -0.44 0 NA
24 hsa-miR-200c-3p CNTN1 3.5 0 -4.98 0 MirTarget; miRNATAP -0.74 0 NA
25 hsa-miR-200c-5p COL11A1 2.96 0 4.69 0 MirTarget; miRNATAP -0.57 0 NA
26 hsa-miR-200c-3p COL4A3 3.5 0 -3.14 0 miRNATAP -0.32 0 NA
27 hsa-miR-200c-3p CREB5 3.5 0 -2.28 0 miRNATAP -0.47 0 NA
28 hsa-miR-200c-3p CYP1B1 3.5 0 -2.82 0 miRNATAP -0.55 0 25860934 Loss of miR 200c up regulates CYP1B1 and confers docetaxel resistance in renal cell carcinoma; Additionally miR-200c which is significantly down-regulated in RCC regulates CYP1B1 expression and activity; An inverse association was also observed between the expression levels of miR-200c and CYP1B1 protein in RCC tissues; Restoration of docetaxel resistance by exogenous expression of CYP1B1 in miR-200c-over-expressing cells indicates that CYP1B1 is a functional target of miR-200c; These results suggest that CYP1B1 up-regulation mediated by low miR-200c is one of the mechanisms underlying resistance of RCC cells to docetaxel; Therefore expression of CYP1B1 and miR-200c in RCC may be useful as a prediction for docetaxel response
29 hsa-miR-200c-3p DACT1 3.5 0 -1.78 2.0E-5 miRNATAP -0.47 0 NA
30 hsa-miR-200c-3p DCBLD2 3.5 0 -0.13 0.73597 MirTarget -0.31 0 NA
31 hsa-miR-200c-3p DDIT4L 3.5 0 -1.9 0.00047 MirTarget -0.47 0 NA
32 hsa-miR-200c-3p DENND5B 3.5 0 -1.35 0.0001 MirTarget; miRNATAP -0.39 0 NA
33 hsa-miR-200c-3p DIXDC1 3.5 0 -3.01 0 MirTarget -0.52 0 NA
34 hsa-miR-200c-3p DMD 3.5 0 -3.69 0 miRNATAP -0.53 0 NA
35 hsa-miR-200c-3p DNAJB5 3.5 0 -2.65 0 miRNATAP -0.52 0 NA
36 hsa-miR-200c-3p DRP2 3.5 0 -1.35 0.00023 mirMAP -0.31 0 NA
37 hsa-miR-200c-3p DTNA 3.5 0 -4.06 0 MirTarget -0.65 0 NA
38 hsa-miR-200c-5p DTNA 2.96 0 -4.06 0 MirTarget; miRNATAP -0.66 0 NA
39 hsa-miR-200c-3p DUSP1 3.5 0 -3.47 0 MirTarget; miRNATAP -0.32 0 NA
40 hsa-miR-200c-3p DZIP1 3.5 0 -1.57 2.0E-5 MirTarget -0.34 0 NA
41 hsa-miR-200c-3p EDNRA 3.5 0 -2.19 0 miRNAWalker2 validate; miRNATAP -0.43 0 NA
42 hsa-miR-200c-5p EML1 2.96 0 -2.07 0 MirTarget -0.33 0 NA
43 hsa-miR-200c-3p F2RL2 3.5 0 -0.07 0.88286 MirTarget -0.4 0 NA
44 hsa-miR-200c-5p FAM110B 2.96 0 -2.49 0 MirTarget -0.52 0 NA
45 hsa-miR-200c-3p FBLN5 3.5 0 -2.76 0 miRNAWalker2 validate; miRTarBase -0.4 0 NA
46 hsa-miR-200c-3p FGF2 3.5 0 -3.46 0 mirMAP -0.58 0 NA
47 hsa-miR-200c-3p FHL1 3.5 0 -4.79 0 MirTarget -0.78 0 NA
48 hsa-miR-200c-3p FLI1 3.5 0 -1.11 7.0E-5 MirTarget; miRNATAP -0.32 0 NA
49 hsa-miR-200c-3p FLNA 3.5 0 -2.63 0 miRNAWalker2 validate -0.57 0 NA
50 hsa-miR-200c-3p FN1 3.5 0 -0.41 0.45793 miRNAWalker2 validate; miRTarBase; MirTarget; miRNATAP -0.66 0 NA
51 hsa-miR-200c-3p FOXF1 3.5 0 -3.6 0 MirTarget -0.33 0 NA
52 hsa-miR-200c-3p FSTL1 3.5 0 -1.2 3.0E-5 MirTarget -0.36 0 NA
53 hsa-miR-200c-3p FYN 3.5 0 -1.47 0 miRNATAP -0.35 0 NA
54 hsa-miR-200c-3p GEM 3.5 0 -3.69 0 MirTarget; miRNATAP -0.6 0 NA
55 hsa-miR-200c-3p GFRA1 3.5 0 -5 0 mirMAP -0.33 0 NA
56 hsa-miR-200c-3p GJC1 3.5 0 -0.97 0.00222 MirTarget; miRNATAP -0.31 0 NA
57 hsa-miR-200c-3p GLIS2 3.5 0 -0.61 0.05279 miRNATAP -0.31 0 NA
58 hsa-miR-200c-5p GNAO1 2.96 0 -3.6 0 MirTarget -0.62 0 NA
59 hsa-miR-200c-3p GNG4 3.5 0 0.22 0.74468 mirMAP -0.42 0 NA
60 hsa-miR-200c-3p GPM6A 3.5 0 -4.43 0 miRNATAP -0.61 0 NA
61 hsa-miR-200c-3p GREM1 3.5 0 0.09 0.91453 MirTarget -0.65 0 NA
62 hsa-miR-200c-3p HLF 3.5 0 -5.48 0 MirTarget; miRNATAP -0.6 0 NA
63 hsa-miR-200c-3p HS3ST3A1 3.5 0 -0.13 0.83157 MirTarget -0.63 0 NA
64 hsa-miR-200c-3p IGSF10 3.5 0 -5.3 0 MirTarget -0.54 0 NA
65 hsa-miR-200c-3p IL6ST 3.5 0 -2.1 2.0E-5 mirMAP -0.35 0 NA
66 hsa-miR-200c-3p ITGA1 3.5 0 -1.43 0 MirTarget -0.34 0 NA
67 hsa-miR-200c-3p ITPR1 3.5 0 -2.58 0 miRNATAP -0.31 0 NA
68 hsa-miR-200c-3p JAZF1 3.5 0 -1.92 0 MirTarget; miRNATAP -0.42 0 NA
69 hsa-miR-200c-3p KCNK2 3.5 0 -3.96 0 miRNATAP -0.5 0 NA
70 hsa-miR-200c-3p KCNQ4 3.5 0 -2.64 0 miRNATAP -0.36 0 NA
71 hsa-miR-200c-3p KIAA1462 3.5 0 -1.72 0 MirTarget -0.39 0 NA
72 hsa-miR-200c-3p KLF9 3.5 0 -2.79 0 miRNAWalker2 validate; miRTarBase; miRNATAP -0.4 0 NA
73 hsa-miR-200c-3p LHFP 3.5 0 -1.83 0 MirTarget; miRNATAP -0.36 0 NA
74 hsa-miR-200c-5p LINGO2 2.96 0 -1.99 0.00051 MirTarget -0.32 0 NA
75 hsa-miR-200c-3p LIX1L 3.5 0 -1.29 0 MirTarget -0.34 0 NA
76 hsa-miR-200c-3p MAF 3.5 0 -1.28 0.00016 miRNATAP -0.36 0 NA
77 hsa-miR-200c-5p MAP1B 2.96 0 -3.18 0 miRNATAP -0.56 0 NA
78 hsa-miR-200c-5p MEF2C 2.96 0 -2.13 0 MirTarget -0.4 0 NA
79 hsa-miR-200c-3p MFAP5 3.5 0 -4.35 0 miRNATAP -0.9 0 NA
80 hsa-miR-200c-3p MITF 3.5 0 -2.11 0 miRNATAP -0.37 0 NA
81 hsa-miR-200c-3p MMD 3.5 0 -0.05 0.87055 miRNATAP -0.31 0 NA
82 hsa-miR-200c-3p MRVI1 3.5 0 -3.2 0 MirTarget -0.43 0 NA
83 hsa-miR-200c-3p MSN 3.5 0 -0.86 0.01366 miRNAWalker2 validate; miRTarBase; MirTarget -0.39 0 NA
84 hsa-miR-200c-3p MSRB3 3.5 0 -3.32 0 mirMAP -0.64 0 NA
85 hsa-miR-200c-5p MSRB3 2.96 0 -3.32 0 MirTarget -0.7 0 NA
86 hsa-miR-200c-3p NCAM1 3.5 0 -5.47 0 miRTarBase -0.87 0 NA
87 hsa-miR-200c-3p NCS1 3.5 0 -1.74 0 miRNATAP -0.3 0 NA
88 hsa-miR-200c-3p NEGR1 3.5 0 -4.78 0 miRNATAP -0.68 0 NA
89 hsa-miR-200c-3p NFASC 3.5 0 -2.96 0 miRNATAP -0.3 0 23185507 miR 200c targets a NF κB up regulated TrkB/NTF3 autocrine signaling loop to enhance anoikis sensitivity in triple negative breast cancer
90 hsa-miR-200c-3p NOG 3.5 0 -1.05 0.08272 MirTarget; miRNATAP -0.38 0 NA
91 hsa-miR-200c-3p NOVA1 3.5 0 -4.22 0 MirTarget; miRNATAP -0.42 0 NA
92 hsa-miR-200c-3p NR3C1 3.5 0 -1.29 4.0E-5 miRNATAP -0.31 0 NA
93 hsa-miR-200c-3p NRG1 3.5 0 -1.24 0.07417 miRNATAP -0.39 0 NA
94 hsa-miR-200c-5p NRK 2.96 0 -1.59 0.0051 miRNATAP -0.37 0 NA
95 hsa-miR-200c-3p NTRK2 3.5 0 -3.44 0 miRNAWalker2 validate; miRTarBase -0.56 0 23209748; 23074172 miR 200c sensitizes breast cancer cells to doxorubicin treatment by decreasing TrkB and Bmi1 expression;miR-200c also targets TrkB a mediator of resistance to anoikis
96 hsa-miR-200c-3p PALM2-AKAP2 3.5 0 -1.62 0 miRNATAP -0.42 0 NA
97 hsa-miR-200c-3p PCDH10 3.5 0 -3.24 0 MirTarget -0.53 0 NA
98 hsa-miR-200c-3p PCSK2 3.5 0 -6.63 0 miRNATAP -0.39 0 NA
99 hsa-miR-200c-3p PDE5A 3.5 0 -2.72 0 miRNATAP -0.3 0 NA
100 hsa-miR-200c-3p PLCL1 3.5 0 -2.36 0 MirTarget -0.41 0 NA
101 hsa-miR-200c-3p PLXNA4 3.5 0 -2.25 5.0E-5 miRNATAP -0.68 0 NA
102 hsa-miR-200c-3p PLXNC1 3.5 0 -0.53 0.2847 miRNATAP -0.43 0 NA
103 hsa-miR-200c-3p PPARGC1A 3.5 0 -4.12 0 mirMAP -0.48 0 NA
104 hsa-miR-200c-3p PPP2R2C 3.5 0 -0.8 0.26616 miRNATAP -0.31 4.0E-5 NA
105 hsa-miR-200c-3p PRKAA2 3.5 0 -3.17 0 MirTarget -0.32 0 NA
106 hsa-miR-200c-3p PRKCB 3.5 0 -3.26 0 MirTarget; miRNATAP -0.49 0 NA
107 hsa-miR-200c-3p PRKG1 3.5 0 -3.09 0 miRNATAP -0.56 0 NA
108 hsa-miR-200c-3p PTHLH 3.5 0 -0.64 0.35954 MirTarget -0.32 1.0E-5 NA
109 hsa-miR-200c-3p PTPRD 3.5 0 -3.63 0 miRNAWalker2 validate -0.63 0 NA
110 hsa-miR-200c-3p PTPRZ1 3.5 0 -3.07 0.00082 MirTarget; miRNATAP -0.42 1.0E-5 NA
111 hsa-miR-200c-3p PYGO1 3.5 0 -2.1 4.0E-5 mirMAP -0.41 0 NA
112 hsa-miR-200c-3p RASSF8 3.5 0 -1.49 0 miRNATAP -0.31 0 NA
113 hsa-miR-200c-3p RECK 3.5 0 -2.39 0 miRNATAP -0.45 0 27574450; 24647918 MiR 200c promotes bladder cancer cell migration and invasion by directly targeting RECK; The luciferase reporter assay showed that RECK was a direct target of miR-200c;Finally we demonstrated that expression of miR-200c in H460 cells suppressed cell growth by targeting RECK followed by activation of the JNK signaling pathway and ER stress; Collectively these data show that miR-200c expression sensitizes H460 cells to RESV and this is likely due to RECK expression
114 hsa-miR-200c-3p REEP1 3.5 0 -4.35 0 MirTarget; miRNATAP -0.61 0 NA
115 hsa-miR-200c-3p RELN 3.5 0 -4.7 0 MirTarget -0.65 0 NA
116 hsa-miR-200c-5p RUNX1T1 2.96 0 -3.29 0 miRNATAP -0.65 0 NA
117 hsa-miR-200c-3p RUSC2 3.5 0 -1.6 0 miRNATAP -0.33 0 NA
118 hsa-miR-200c-5p SAMD4A 2.96 0 -2.18 0 mirMAP -0.37 0 NA
119 hsa-miR-200c-3p SCN3A 3.5 0 -2.33 0 mirMAP -0.32 0 NA
120 hsa-miR-200c-3p SCUBE3 3.5 0 -2.48 0 mirMAP -0.39 0 NA
121 hsa-miR-200c-3p SDC2 3.5 0 -2.01 0 miRNATAP -0.33 0 NA
122 hsa-miR-200c-3p SFMBT2 3.5 0 -1.41 0.00042 mirMAP -0.35 0 NA
123 hsa-miR-200c-3p SGCD 3.5 0 -3.55 0 mirMAP -0.67 0 NA
124 hsa-miR-200c-3p SGIP1 3.5 0 -0.44 0.23102 MirTarget -0.32 0 NA
125 hsa-miR-200c-3p SHE 3.5 0 -2.12 0 mirMAP -0.35 0 NA
126 hsa-miR-200c-3p SIRPA 3.5 0 -0.55 0.11927 MirTarget -0.38 0 NA
127 hsa-miR-200c-3p SLC16A12 3.5 0 -0.98 0.04552 mirMAP; miRNATAP -0.31 0 NA
128 hsa-miR-200c-3p SLC16A2 3.5 0 -1.54 0 miRNATAP -0.4 0 NA
129 hsa-miR-200c-5p SLC18A2 2.96 0 -2.15 0 MirTarget; miRNATAP -0.38 0 NA
130 hsa-miR-200c-3p SLC30A4 3.5 0 -1.13 0.0037 mirMAP -0.37 0 NA
131 hsa-miR-200c-3p SLC6A17 3.5 0 0.94 0.05681 mirMAP; miRNATAP -0.34 0 NA
132 hsa-miR-200c-5p SLIT3 2.96 0 -3.6 0 mirMAP -0.36 0 NA
133 hsa-miR-200c-3p SNAP25 3.5 0 -1.15 0.03273 MirTarget; miRNATAP -0.46 0 NA
134 hsa-miR-200c-3p STARD8 3.5 0 -1.76 0 mirMAP -0.38 0 NA
135 hsa-miR-200c-3p SULF1 3.5 0 0.17 0.75761 MirTarget; miRNATAP -0.5 0 NA
136 hsa-miR-200c-3p SV2B 3.5 0 -2.33 7.0E-5 mirMAP -0.6 0 NA
137 hsa-miR-200c-3p SYDE1 3.5 0 -0.81 0.00222 MirTarget; miRNATAP -0.36 0 NA
138 hsa-miR-200c-3p SYT11 3.5 0 -2.12 0 mirMAP -0.47 0 NA
139 hsa-miR-200c-3p TBX18 3.5 0 -2.2 0.00125 MirTarget -0.48 0 NA
140 hsa-miR-200c-3p TCF4 3.5 0 -1.61 0 mirMAP; miRNATAP -0.32 0 NA
141 hsa-miR-200c-3p TCF7L1 3.5 0 -1.3 0.00022 miRNAWalker2 validate -0.32 0 NA
142 hsa-miR-200c-3p TFEC 3.5 0 0.02 0.97058 MirTarget -0.38 0 NA
143 hsa-miR-200c-3p THEMIS 3.5 0 -1.31 0.01187 mirMAP -0.31 0 NA
144 hsa-miR-200c-3p TIMP2 3.5 0 -1.75 1.0E-5 miRTarBase -0.48 0 NA
145 hsa-miR-200c-3p TUBB2A 3.5 0 -0.68 0.0629 MirTarget; miRNATAP -0.3 0 NA
146 hsa-miR-200c-5p VASN 2.96 0 -1.27 7.0E-5 MirTarget -0.33 0 NA
147 hsa-miR-200c-3p VAT1L 3.5 0 -1.21 0.00422 MirTarget; miRNATAP -0.3 0 NA
148 hsa-miR-200c-3p WIPF1 3.5 0 -1.36 1.0E-5 MirTarget; miRNATAP -0.42 0 NA
149 hsa-miR-200c-3p ZCCHC24 3.5 0 -2.71 0 MirTarget; miRNATAP -0.47 0 NA
150 hsa-miR-200c-3p ZDHHC15 3.5 0 -2.82 0 MirTarget -0.37 0 NA

Over-represented Gene Ontology Biological Process

NumGOOverlapSizeP ValueAdj. P Value
1 CELL DEVELOPMENT 41 1426 3.996e-14 1.859e-10
2 REGULATION OF MULTICELLULAR ORGANISMAL DEVELOPMENT 44 1672 8.12e-14 1.889e-10
3 REGULATION OF NEURON DIFFERENTIATION 25 554 6.135e-13 9.516e-10
4 REGULATION OF CELL DEVELOPMENT 30 836 8.438e-13 9.816e-10
5 REGULATION OF NERVOUS SYSTEM DEVELOPMENT 27 750 1.285e-11 1.196e-08
6 REGULATION OF CELL DIFFERENTIATION 38 1492 1.703e-11 1.321e-08
7 POSITIVE REGULATION OF NEURON DIFFERENTIATION 17 306 1.702e-10 1.131e-07
8 NEUROGENESIS 35 1402 2.245e-10 1.306e-07
9 REGULATION OF NEURON PROJECTION DEVELOPMENT 19 408 2.717e-10 1.405e-07
10 MOVEMENT OF CELL OR SUBCELLULAR COMPONENT 33 1275 3.283e-10 1.528e-07
11 MUSCLE SYSTEM PROCESS 16 282 4.447e-10 1.806e-07
12 POSITIVE REGULATION OF CELL DEVELOPMENT 20 472 4.659e-10 1.806e-07
13 REGULATION OF ANATOMICAL STRUCTURE MORPHOGENESIS 29 1021 5.709e-10 2.043e-07
14 POSITIVE REGULATION OF NERVOUS SYSTEM DEVELOPMENT 19 437 8.569e-10 2.848e-07
15 CELLULAR COMPONENT MORPHOGENESIS 26 900 3.58e-09 1.11e-06
16 POSITIVE REGULATION OF DEVELOPMENTAL PROCESS 29 1142 7.259e-09 2.111e-06
17 REGULATION OF CELL PROJECTION ORGANIZATION 20 558 8.169e-09 2.236e-06
18 REGULATION OF CELL MORPHOGENESIS INVOLVED IN DIFFERENTIATION 15 337 4.189e-08 1.083e-05
19 LOCOMOTION 27 1114 6.796e-08 1.664e-05
20 EXTRACELLULAR STRUCTURE ORGANIZATION 14 304 7.961e-08 1.852e-05
21 FOREBRAIN DEVELOPMENT 15 357 8.904e-08 1.973e-05
22 NEURON PROJECTION DEVELOPMENT 18 545 1.642e-07 3.473e-05
23 POSITIVE REGULATION OF NEURON PROJECTION DEVELOPMENT 12 232 2.024e-07 3.924e-05
24 REGULATION OF CELL MORPHOGENESIS 18 552 1.983e-07 3.924e-05
25 MUSCLE CONTRACTION 12 233 2.12e-07 3.946e-05
26 NEURON DEVELOPMENT 20 687 2.452e-07 4.288e-05
27 HEART PROCESS 8 85 2.58e-07 4.288e-05
28 POSITIVE REGULATION OF CELL DIFFERENTIATION 22 823 2.52e-07 4.288e-05
29 CELL MORPHOGENESIS INVOLVED IN DIFFERENTIATION 17 513 3.542e-07 5.553e-05
30 REGULATION OF CELLULAR COMPONENT MOVEMENT 21 771 3.58e-07 5.553e-05
31 NEURON PROJECTION MORPHOGENESIS 15 402 4.09e-07 6.139e-05
32 POSITIVE REGULATION OF MULTICELLULAR ORGANISMAL PROCESS 29 1395 5.315e-07 7.494e-05
33 POSITIVE REGULATION OF CELL PROJECTION ORGANIZATION 13 303 5.297e-07 7.494e-05
34 CENTRAL NERVOUS SYSTEM DEVELOPMENT 22 872 6.69e-07 9.155e-05
35 NEURON DIFFERENTIATION 22 874 6.951e-07 9.24e-05
36 CIRCULATORY SYSTEM PROCESS 14 366 7.56e-07 9.772e-05
37 CELL MORPHOGENESIS INVOLVED IN NEURON DIFFERENTIATION 14 368 8.066e-07 0.0001014
38 STRIATED MUSCLE CONTRACTION 8 99 8.397e-07 0.0001028
39 TISSUE DEVELOPMENT 30 1518 9.447e-07 0.0001127
40 CELL MOTILITY 21 835 1.297e-06 0.0001472
41 LOCALIZATION OF CELL 21 835 1.297e-06 0.0001472
42 REGULATION OF CELLULAR RESPONSE TO GROWTH FACTOR STIMULUS 11 229 1.374e-06 0.0001523
43 CELL PART MORPHOGENESIS 18 633 1.437e-06 0.0001555
44 REGULATION OF CARDIAC MUSCLE TISSUE DEVELOPMENT 6 48 1.584e-06 0.0001675
45 HEAD DEVELOPMENT 19 709 1.727e-06 0.0001786
46 NEGATIVE REGULATION OF CELL PROLIFERATION 18 643 1.794e-06 0.0001815
47 REGULATION OF CARDIAC MUSCLE CELL PROLIFERATION 5 29 2.355e-06 0.0002332
48 SYSTEM PROCESS 32 1785 3.141e-06 0.0003045
49 EMBRYONIC MORPHOGENESIS 16 539 3.329e-06 0.0003161
50 REGULATION OF TRANSPORT 32 1804 3.927e-06 0.0003654
51 CELL PROJECTION ORGANIZATION 21 902 4.355e-06 0.0003973
52 MUSCLE STRUCTURE DEVELOPMENT 14 432 5.231e-06 0.0004681
53 REGULATION OF CELL PROLIFERATION 28 1496 6.583e-06 0.0005779
54 REGULATION OF HEART CONTRACTION 10 221 7.144e-06 0.0006155
55 CELL COMMUNICATION INVOLVED IN CARDIAC CONDUCTION 5 37 8.235e-06 0.0006842
56 CARDIAC MUSCLE CELL ACTION POTENTIAL 5 37 8.235e-06 0.0006842
57 ION TRANSPORT 25 1262 8.484e-06 0.0006926
58 TELENCEPHALON DEVELOPMENT 10 228 9.39e-06 0.0007533
59 REGULATION OF CARDIAC MUSCLE CONTRACTION BY REGULATION OF THE RELEASE OF SEQUESTERED CALCIUM ION 4 19 1.108e-05 0.0008738
60 REGULATION OF MUSCLE TISSUE DEVELOPMENT 7 103 1.315e-05 0.00102
61 EMBRYO DEVELOPMENT 20 894 1.347e-05 0.001028
62 SYNAPSE ORGANIZATION 8 145 1.458e-05 0.001077
63 MESENCHYME DEVELOPMENT 9 190 1.443e-05 0.001077
64 REGULATION OF HEART GROWTH 5 42 1.559e-05 0.001133
65 REGULATION OF SEQUESTERING OF CALCIUM ION 7 107 1.688e-05 0.001208
66 CELL CELL SIGNALING INVOLVED IN CARDIAC CONDUCTION 4 22 2.055e-05 0.001448
67 REGULATION OF TRANSMEMBRANE TRANSPORT 13 426 2.168e-05 0.001506
68 REGULATION OF ION HOMEOSTASIS 9 201 2.256e-05 0.001544
69 RESPONSE TO WOUNDING 15 563 2.444e-05 0.00162
70 REGULATION OF GROWTH 16 633 2.459e-05 0.00162
71 REGULATION OF CARDIAC MUSCLE CONTRACTION BY CALCIUM ION SIGNALING 4 23 2.472e-05 0.00162
72 REGULATION OF PHOSPHORUS METABOLIC PROCESS 28 1618 2.785e-05 0.0018
73 CARDIOVASCULAR SYSTEM DEVELOPMENT 18 788 2.868e-05 0.001803
74 CIRCULATORY SYSTEM DEVELOPMENT 18 788 2.868e-05 0.001803
75 SECOND MESSENGER MEDIATED SIGNALING 8 160 2.97e-05 0.001836
76 NEGATIVE REGULATION OF RESPONSE TO STIMULUS 25 1360 2.999e-05 0.001836
77 NEGATIVE REGULATION OF CELL COMMUNICATION 23 1192 3.084e-05 0.001864
78 REGULATION OF SYSTEM PROCESS 14 507 3.13e-05 0.001867
79 CATION TRANSPORT 18 796 3.273e-05 0.001892
80 BIOLOGICAL ADHESION 21 1032 3.294e-05 0.001892
81 POSITIVE REGULATION OF CELL MORPHOGENESIS INVOLVED IN DIFFERENTIATION 8 162 3.246e-05 0.001892
82 ANATOMICAL STRUCTURE FORMATION INVOLVED IN MORPHOGENESIS 20 957 3.558e-05 0.001925
83 POSITIVE REGULATION OF PHOSPHATE METABOLIC PROCESS 21 1036 3.485e-05 0.001925
84 POSITIVE REGULATION OF PHOSPHORUS METABOLIC PROCESS 21 1036 3.485e-05 0.001925
85 REGULATION OF DENDRITE DEVELOPMENT 7 120 3.548e-05 0.001925
86 REGULATION OF RELEASE OF SEQUESTERED CALCIUM ION INTO CYTOSOL BY SARCOPLASMIC RETICULUM 4 25 3.491e-05 0.001925
87 BEHAVIOR 14 516 3.79e-05 0.002004
88 DIVALENT INORGANIC CATION TRANSPORT 10 268 3.771e-05 0.002004
89 TISSUE MIGRATION 6 84 4.197e-05 0.002151
90 MULTICELLULAR ORGANISMAL SIGNALING 7 123 4.158e-05 0.002151
91 REGULATION OF AXONOGENESIS 8 168 4.207e-05 0.002151
92 REGULATION OF ION TRANSPORT 15 592 4.346e-05 0.002198
93 MUSCLE ORGAN DEVELOPMENT 10 277 4.981e-05 0.002465
94 ION TRANSMEMBRANE TRANSPORT 18 822 4.967e-05 0.002465
95 CALCIUM ION TRANSPORT 9 223 5.085e-05 0.00249
96 TISSUE MORPHOGENESIS 14 533 5.378e-05 0.002607
97 POSITIVE REGULATION OF CELLULAR COMPONENT ORGANIZATION 22 1152 5.453e-05 0.002616
98 REGULATION OF MEMBRANE POTENTIAL 11 343 6.101e-05 0.002897
99 POSITIVE REGULATION OF CARDIAC MUSCLE TISSUE DEVELOPMENT 4 29 6.402e-05 0.002992
100 POSITIVE REGULATION OF MUSCLE TISSUE DEVELOPMENT 5 56 6.43e-05 0.002992
101 POSITIVE REGULATION OF MOLECULAR FUNCTION 29 1791 6.567e-05 0.003025
102 REGULATION OF DEVELOPMENTAL GROWTH 10 289 7.097e-05 0.003238
103 ACTIN FILAMENT BASED MOVEMENT 6 93 7.443e-05 0.003298
104 RESPONSE TO KETONE 8 182 7.401e-05 0.003298
105 CELLULAR RESPONSE TO ENDOGENOUS STIMULUS 20 1008 7.313e-05 0.003298
106 ACTION POTENTIAL 6 94 7.902e-05 0.003469
107 TRANSMEMBRANE TRANSPORT 21 1098 8.023e-05 0.003489
108 MUSCLE CELL DIFFERENTIATION 9 237 8.124e-05 0.0035
109 RESPONSE TO ALKALOID 7 137 8.246e-05 0.00352
110 REGULATION OF BLOOD CIRCULATION 10 295 8.415e-05 0.00356
111 RESPONSE TO ENDOGENOUS STIMULUS 25 1450 8.495e-05 0.003561
112 CARDIAC MUSCLE TISSUE DEVELOPMENT 7 140 9.45e-05 0.003926
113 SENSORY ORGAN DEVELOPMENT 13 493 9.643e-05 0.003971
114 STEM CELL DIFFERENTIATION 8 190 9.992e-05 0.004043
115 MODULATION OF SYNAPTIC TRANSMISSION 10 301 9.935e-05 0.004043
116 FOREBRAIN CELL MIGRATION 5 62 0.000105 0.004151
117 CARDIAC VENTRICLE MORPHOGENESIS 5 62 0.000105 0.004151
118 NEGATIVE REGULATION OF CELL DEATH 18 872 0.0001053 0.004151
119 POSITIVE REGULATION OF CARDIAC MUSCLE CELL DIFFERENTIATION 3 13 0.0001141 0.004463
120 CONNECTIVE TISSUE DEVELOPMENT 8 194 0.0001155 0.004477
121 REGULATION OF MUSCLE SYSTEM PROCESS 8 195 0.0001196 0.0046
122 REGULATION OF NEUROTRANSMITTER TRANSPORT 5 64 0.0001223 0.004664
123 CARTILAGE DEVELOPMENT 7 147 0.0001282 0.00485
124 REGULATION OF MUSCLE ORGAN DEVELOPMENT 6 103 0.0001313 0.004925
125 REGULATION OF TRANSPORTER ACTIVITY 8 198 0.0001329 0.004948
126 METAL ION TRANSPORT 14 582 0.0001363 0.005032
127 INORGANIC ION TRANSMEMBRANE TRANSPORT 14 583 0.0001387 0.005082
128 REGULATION OF CARDIAC MUSCLE CONTRACTION 5 66 0.0001416 0.005147
129 MEMBRANE DEPOLARIZATION DURING CARDIAC MUSCLE CELL ACTION POTENTIAL 3 14 0.0001445 0.005211
130 REGULATION OF HOMEOSTATIC PROCESS 12 447 0.0001526 0.005419
131 CARDIAC VENTRICLE DEVELOPMENT 6 106 0.0001537 0.005419
132 REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 28 1784 0.0001527 0.005419
133 NEGATIVE REGULATION OF MULTICELLULAR ORGANISMAL PROCESS 19 983 0.0001576 0.005512
134 PALLIUM DEVELOPMENT 7 153 0.0001643 0.005706
135 NEURON PROJECTION GUIDANCE 8 205 0.0001688 0.005817
136 NEGATIVE REGULATION OF NITROGEN COMPOUND METABOLIC PROCESS 25 1517 0.0001727 0.00591
137 POSITIVE REGULATION OF AXONOGENESIS 5 69 0.0001749 0.005939
138 NEGATIVE REGULATION OF LOCOMOTION 9 263 0.0001784 0.005951
139 REGULATION OF TRANSMEMBRANE RECEPTOR PROTEIN SERINE THREONINE KINASE SIGNALING PATHWAY 8 207 0.0001803 0.005951
140 REGULATION OF N METHYL D ASPARTATE SELECTIVE GLUTAMATE RECEPTOR ACTIVITY 3 15 0.0001796 0.005951
141 TUBE MORPHOGENESIS 10 323 0.0001766 0.005951
142 COLLAGEN FIBRIL ORGANIZATION 4 38 0.0001887 0.006141
143 NEURON MIGRATION 6 110 0.0001883 0.006141
144 REGULATION OF CELL GROWTH 11 391 0.0001932 0.006242
145 RESPONSE TO MECHANICAL STIMULUS 8 210 0.0001989 0.006384
146 MEMBRANE DEPOLARIZATION DURING ACTION POTENTIAL 4 39 0.0002091 0.006618
147 CALCIUM ION TRANSMEMBRANE TRANSPORT 7 159 0.0002083 0.006618
148 ORGAN MORPHOGENESIS 17 841 0.000212 0.006666
149 ESTABLISHMENT OR MAINTENANCE OF MONOPOLAR CELL POLARITY 3 16 0.0002198 0.006864
150 HEART DEVELOPMENT 12 466 0.0002239 0.006945
151 REGULATION OF ORGAN GROWTH 5 73 0.0002281 0.006983
152 CELLULAR RESPONSE TO KETONE 5 73 0.0002281 0.006983
153 POSITIVE REGULATION OF GENE EXPRESSION 27 1733 0.00023 0.006996
154 POSITIVE REGULATION OF PEPTIDYL TYROSINE PHOSPHORYLATION 7 162 0.0002336 0.007057
155 VASCULATURE DEVELOPMENT 12 469 0.0002374 0.007126
156 NEPHRON DEVELOPMENT 6 115 0.0002398 0.007154
157 WOUND HEALING 12 470 0.000242 0.007161
158 ACTIN MEDIATED CELL CONTRACTION 5 74 0.0002432 0.007161
159 REGULATION OF ANATOMICAL STRUCTURE SIZE 12 472 0.0002516 0.007317
160 REGULATION OF CALCIUM ION TRANSMEMBRANE TRANSPORT 6 116 0.0002514 0.007317
161 REGULATION OF RELEASE OF SEQUESTERED CALCIUM ION INTO CYTOSOL 5 75 0.000259 0.007485
162 REGULATION OF RECEPTOR ACTIVITY 6 117 0.0002633 0.007563
163 REGULATION OF INTRACELLULAR SIGNAL TRANSDUCTION 26 1656 0.0002711 0.007739
164 REGULATION OF CELL DEATH 24 1472 0.0002775 0.007872
165 CELLULAR RESPONSE TO HORMONE STIMULUS 13 552 0.0002915 0.008221
166 NEGATIVE REGULATION OF CELLULAR RESPONSE TO GROWTH FACTOR STIMULUS 6 121 0.0003157 0.008826
167 RESPONSE TO CAFFEINE 3 18 0.0003168 0.008826
168 DENDRITE DEVELOPMENT 5 79 0.0003301 0.009035
169 EMBRYONIC SKELETAL SYSTEM DEVELOPMENT 6 122 0.00033 0.009035
170 REGULATION OF STRIATED MUSCLE CONTRACTION 5 79 0.0003301 0.009035
171 POSITIVE REGULATION OF PROTEIN METABOLIC PROCESS 24 1492 0.0003382 0.009202
NumGOOverlapSizeP ValueAdj. P Value
NumGOOverlapSizeP ValueAdj. P Value
1 SOMATODENDRITIC COMPARTMENT 22 650 3.894e-09 2.274e-06
2 NEURON PROJECTION 26 942 9.159e-09 2.675e-06
3 NEURON PART 30 1265 1.811e-08 3.525e-06
4 SYNAPSE 22 754 5.544e-08 8.095e-06
5 CELL BODY 17 494 2.085e-07 2.435e-05
6 PLASMA MEMBRANE PROTEIN COMPLEX 17 510 3.263e-07 2.722e-05
7 DENDRITE 16 451 3.24e-07 2.722e-05
8 CELL PROJECTION 32 1786 3.179e-06 0.000232
9 SYNAPSE PART 17 610 3.763e-06 0.0002441
10 CELL JUNCTION 24 1151 5.596e-06 0.0003268
11 POSTSYNAPSE 12 378 3.095e-05 0.001643
12 SARCOLEMMA 7 125 4.61e-05 0.002071
13 MEMBRANE REGION 22 1134 4.315e-05 0.002071

Over-represented Pathway

NumPathwayPathviewOverlapSizeP ValueAdj. P Value
1 hsa04270_Vascular_smooth_muscle_contraction 7 116 2.852e-05 0.004039
2 hsa04512_ECM.receptor_interaction 6 85 4.487e-05 0.004039
3 hsa04151_PI3K_AKT_signaling_pathway 11 351 7.496e-05 0.004497
4 hsa04971_Gastric_acid_secretion 5 74 0.0002432 0.01094
5 hsa04970_Salivary_secretion 5 89 0.0005723 0.01807
6 hsa04540_Gap_junction 5 90 0.0006024 0.01807
7 hsa04510_Focal_adhesion 7 200 0.0008258 0.02032
8 hsa04010_MAPK_signaling_pathway 8 268 0.0009999 0.02032
9 hsa04916_Melanogenesis 5 101 0.001016 0.02032
10 hsa04730_Long.term_depression 4 70 0.001945 0.03501
11 hsa04260_Cardiac_muscle_contraction 4 77 0.002756 0.04511
12 hsa04514_Cell_adhesion_molecules_.CAMs. 5 136 0.003742 0.05613
13 hsa04912_GnRH_signaling_pathway 4 101 0.007238 0.09306
14 hsa04972_Pancreatic_secretion 4 101 0.007238 0.09306
15 hsa04020_Calcium_signaling_pathway 5 177 0.01113 0.1336
16 hsa04720_Long.term_potentiation 3 70 0.01597 0.1797
17 hsa04360_Axon_guidance 4 130 0.01704 0.1805
18 hsa04810_Regulation_of_actin_cytoskeleton 5 214 0.02334 0.2334
19 hsa04960_Aldosterone.regulated_sodium_reabsorption 2 42 0.04004 0.3794
20 hsa04973_Carbohydrate_digestion_and_absorption 2 44 0.04357 0.3921
21 hsa04380_Osteoclast_differentiation 3 128 0.07294 0.6252
22 hsa04920_Adipocytokine_signaling_pathway 2 68 0.09347 0.7289
23 hsa04976_Bile_secretion 2 71 0.1005 0.7289
24 hsa04014_Ras_signaling_pathway 4 236 0.1039 0.7289
25 hsa04520_Adherens_junction 2 73 0.1053 0.7289
26 hsa04070_Phosphatidylinositol_signaling_system 2 78 0.1175 0.7712
27 hsa04664_Fc_epsilon_RI_signaling_pathway 2 79 0.12 0.7712
28 hsa04974_Protein_digestion_and_absorption 2 81 0.125 0.7756
29 hsa04012_ErbB_signaling_pathway 2 87 0.1402 0.8415
30 hsa04666_Fc_gamma_R.mediated_phagocytosis 2 95 0.1612 0.8793
31 hsa04062_Chemokine_signaling_pathway 3 189 0.1718 0.9097
32 hsa04114_Oocyte_meiosis 2 114 0.2128 1
33 hsa04670_Leukocyte_transendothelial_migration 2 117 0.2211 1
34 hsa04530_Tight_junction 2 133 0.2658 1
35 hsa04650_Natural_killer_cell_mediated_cytotoxicity 2 136 0.2742 1
36 hsa04910_Insulin_signaling_pathway 2 138 0.2798 1
37 hsa04310_Wnt_signaling_pathway 2 151 0.316 1
38 hsa04390_Hippo_signaling_pathway 2 154 0.3243 1
39 hsa04630_Jak.STAT_signaling_pathway 2 155 0.3271 1
40 hsa00230_Purine_metabolism 2 162 0.3463 1

Quest ID: e35b812f501773a2af32d74de684f1c4