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This regulatory network was inferred from the input dataset. The miRNAs and mRNAs are presented as round and rectangle nodes respectively. The numerical value popped up upon mouse over the gene node is the log2 transformed fold-change of the gene expression between the two groups. All of the nodes are clickable, and the detailed information of the miRNAs/mRNAs and related cancer pathway will be displayed in another window. The edges between nodes are supported by both interactions (predicted or experimentally verified) and correlations learnt from cancer dataset. The numerical value popped up upon mouse over the edge is the correlation beat value (effect size) between the two nodes. The experimental evidences of the edges reported in previous cancer studies are highlighted by red/orange color. All of these information can be accessed by the "mouse-over" action. This network shows a full map of the miRNA-mRNA regulation of the input gene list(s), and the hub miRNAs (with the high network degree/betweenness centrality) would be the potential cancer drivers or tumor suppressors. The full result table can be accessed in the "Regulations" tab.

"miRNACancerMAP" is also a network visualization tool for users to draw their regulatory network by personal customization. Users can set the complexity of the network by limiting the number of nodes or edges. And the color of the nodes can be defined by different categories of the mRNAs and miRNAs, such as Gene-Ontology, pathway, and expression status. Users can also select to use network degree or network betweenness centrality to define the node size. And edges can be black or colored by the correlation. Purple edge means negative correlation (mostly found between miRNA and mRNA), and blue edge means positive correlation (found in PPI or miRNA-miRNA sponge effect). We can also add the protein-protein interactions (PPI) into the network. This result will show the cluster of genes regulated by some specific miRNAs. Additionally, miRNA-miRNA edges can be added by the "miRNA sponge" button, presenting some clusters of miRNAs that have the interactions via sponge effect.

miRNA-gene regulations

(Download full result)

Num microRNA           Gene miRNA log2FC miRNA pvalue Gene log2FC Gene pvalue Interaction Correlation beta Correlation P-value PMID Reported in cancer studies
1 hsa-miR-361-5p ACLY 0.08 0.31404 0.64 0 miRNAWalker2 validate -0.11 0.03564 NA
2 hsa-miR-361-5p ACTG1 0.08 0.31404 -0.14 0.09417 miRNAWalker2 validate -0.11 0.01405 NA
3 hsa-miR-15a-5p ACVR1B 0.78 0 -0.22 0.01253 miRNAWalker2 validate -0.16 0 NA
4 hsa-miR-15a-5p AKT3 0.78 0 0.76 5.0E-5 miRNAWalker2 validate; miRTarBase -0.27 0.00011 NA
5 hsa-miR-15a-5p APP 0.78 0 0.97 0 miRNAWalker2 validate -0.13 0.00443 NA
6 hsa-miR-361-5p ARF4 0.08 0.31404 -0.22 0.00791 miRNAWalker2 validate -0.22 0 NA
7 hsa-miR-15a-5p ASXL2 0.78 0 -0.29 0.17368 miRNAWalker2 validate -0.72 0 NA
8 hsa-miR-15a-5p ATF2 0.78 0 0.1 0.47373 miRNAWalker2 validate -0.45 0 NA
9 hsa-miR-125a-5p ATL2 0.22 0.11955 -0.18 0.07378 miRNAWalker2 validate -0.13 3.0E-5 NA
10 hsa-miR-361-5p ATP6V1A 0.08 0.31404 0.03 0.76682 miRNAWalker2 validate -0.11 0.02067 NA
11 hsa-miR-590-3p ATXN1 0.22 0.09659 -0.05 0.68142 miRNAWalker2 validate -0.19 0 NA
12 hsa-miR-15a-5p BACE1 0.78 0 -0.15 0.17214 miRNAWalker2 validate -0.3 0 NA
13 hsa-miR-181b-5p BCL2 0.97 0 -0.91 1.0E-5 miRNAWalker2 validate; miRTarBase -0.37 0 25524579 Moreover we also found miR-181 reduction was associated with increased Bcl-2 levels and miR-181 was further suggested to exert its pro-apoptotic function mainly through targeting Bcl-2 expression
14 hsa-miR-181b-5p BPTF 0.97 0 -0.15 0.11807 miRNAWalker2 validate -0.18 0 NA
15 hsa-miR-15a-5p BTRC 0.78 0 -0.38 0 miRNAWalker2 validate -0.17 0 NA
16 hsa-miR-15a-5p CADM1 0.78 0 -1.32 0 miRNAWalker2 validate; miRTarBase -0.52 0 NA
17 hsa-miR-361-5p CALCOCO2 0.08 0.31404 -0.3 2.0E-5 miRNAWalker2 validate -0.22 0 NA
18 hsa-miR-15a-5p CALD1 0.78 0 0.87 0 miRNAWalker2 validate -0.28 1.0E-5 NA
19 hsa-miR-181b-5p CAT 0.97 0 -0.74 0 miRNAWalker2 validate -0.13 0.00459 NA
20 hsa-miR-181b-5p CBX7 0.97 0 -1.23 0 miRNAWalker2 validate; miRTarBase -0.42 0 NA
21 hsa-miR-15a-5p CCND1 0.78 0 -0.01 0.95947 miRNAWalker2 validate; miRTarBase -0.32 5.0E-5 22922827 CCND1 has been found to be a target of miR-15a and miR-16-1 through analysis of complementary sequences between microRNAs and CCND1 mRNA; Moreover the transcription of CCND1 is suppressed by miR-15a and miR-16-1 via direct binding to the CCND1 3'-untranslated region 3'-UTR
22 hsa-miR-15a-5p CCNYL1 0.78 0 -0.1 0.38945 miRNAWalker2 validate -0.21 0 NA
23 hsa-miR-361-5p CD46 0.08 0.31404 -0.25 0.01424 miRNAWalker2 validate -0.13 0.0173 NA
24 hsa-miR-15a-5p CLCN3 0.78 0 -0.98 0 miRTarBase -0.5 0 NA
25 hsa-miR-15a-5p CNN3 0.78 0 -0.81 0 miRNAWalker2 validate -0.23 1.0E-5 NA
26 hsa-miR-125a-5p CORO1C 0.22 0.11955 0.63 0 miRNAWalker2 validate -0.16 0 NA
27 hsa-miR-15a-5p CREBL2 0.78 0 -0.15 0.06138 miRNAWalker2 validate -0.16 0 NA
28 hsa-miR-125a-5p CRK 0.22 0.11955 -0.08 0.34592 miRNAWalker2 validate -0.21 0 NA
29 hsa-miR-15a-5p CRKL 0.78 0 0.53 0 miRTarBase -0.14 6.0E-5 NA
30 hsa-miR-125a-5p DIP2A 0.22 0.11955 -0.16 0.06781 miRNAWalker2 validate -0.13 0 NA
31 hsa-miR-15a-5p DLK1 0.78 0 -5.53 0 miRNAWalker2 validate -0.95 0 NA
32 hsa-miR-361-5p DOCK6 0.08 0.31404 0.31 0.00123 miRNAWalker2 validate -0.16 0.00272 NA
33 hsa-miR-15a-5p DSTYK 0.78 0 -0.17 0.0232 miRNAWalker2 validate -0.16 0 NA
34 hsa-miR-361-5p DUSP3 0.08 0.31404 -0.61 0 miRNAWalker2 validate -0.14 0.00121 NA
35 hsa-miR-125a-5p E2F7 0.22 0.11955 2.22 0 miRNAWalker2 validate -0.2 0.00149 NA
36 hsa-miR-200c-3p EDNRA 0.63 0.00013 0.5 0.01433 miRNAWalker2 validate -0.36 0 NA
37 hsa-miR-181b-5p EP300 0.97 0 -0.04 0.77828 miRNAWalker2 validate -0.25 0 NA
38 hsa-miR-361-5p EPHA4 0.08 0.31404 -0.36 0.0644 miRNAWalker2 validate -0.28 0.00942 NA
39 hsa-miR-125a-5p ERBB3 0.22 0.11955 -1.15 0 miRNAWalker2 validate -0.25 0 NA
40 hsa-miR-125a-5p ERMP1 0.22 0.11955 -0.98 0 miRNAWalker2 validate -0.33 0 NA
41 hsa-miR-200c-3p ERRFI1 0.63 0.00013 -0.15 0.33179 miRNAWalker2 validate; miRTarBase -0.14 0.00075 NA
42 hsa-miR-15a-5p FAM69A 0.78 0 1.03 0 miRNAWalker2 validate -0.1 0.02484 NA
43 hsa-miR-15a-5p FASN 0.78 0 -0.08 0.56053 miRNAWalker2 validate -0.18 0.00016 27713175 Both miR-15a and miR-16-1 contributes to inhibiting FASN expression and breast cancer cell proliferation; In conclusion we demonstrated that FASN expression is primarily downregulated by miR-15a and miR-16-1 in mammary cells and FASN is one of the major targets of these two tumor suppressive microRNAs
44 hsa-miR-200c-3p FBLN5 0.63 0.00013 -0.78 0.00018 miRNAWalker2 validate; miRTarBase -0.4 0 NA
45 hsa-miR-15a-5p FBXO3 0.78 0 -0.8 0 miRNAWalker2 validate -0.16 2.0E-5 NA
46 hsa-miR-125a-5p FERMT1 0.22 0.11955 1.28 0 miRNAWalker2 validate -0.22 0.00031 NA
47 hsa-miR-15a-5p FGF7 0.78 0 -2.02 0 miRTarBase -0.76 0 NA
48 hsa-miR-200c-3p FHOD1 0.63 0.00013 0.7 0 miRNAWalker2 validate -0.26 0 22144583 MicroRNA 200c represses migration and invasion of breast cancer cells by targeting actin regulatory proteins FHOD1 and PPM1F; We identified FHOD1 and PPM1F direct regulators of the actin cytoskeleton as novel targets of miR-200c; Remarkably expression levels of FHOD1 and PPM1F were inversely correlated with the level of miR-200c in breast cancer cell lines breast cancer patient samples and 58 cancer cell lines of various origins
49 hsa-miR-200c-3p FLNA 0.63 0.00013 0.95 0 miRNAWalker2 validate -0.12 0.0013 NA
50 hsa-miR-200c-3p FLT1 0.63 0.00013 0.74 0 miRNAWalker2 validate; miRTarBase -0.16 5.0E-5 NA
51 hsa-miR-200c-3p FN1 0.63 0.00013 2.78 0 miRNAWalker2 validate; miRTarBase -0.53 0 NA
52 hsa-miR-15a-5p FOXO1 0.78 0 -0.4 0.00142 miRNAWalker2 validate -0.23 0 NA
53 hsa-miR-125a-5p G2E3 0.22 0.11955 0.48 0 miRNAWalker2 validate -0.12 0.00014 NA
54 hsa-miR-15a-5p GCLM 0.78 0 -0.01 0.97735 miRNAWalker2 validate -0.15 0.0341 NA
55 hsa-miR-590-3p GFPT1 0.22 0.09659 -0.24 0.01176 miRNAWalker2 validate -0.12 9.0E-5 NA
56 hsa-miR-15a-5p GOLGA5 0.78 0 0.1 0.17306 miRNAWalker2 validate -0.17 0 NA
57 hsa-miR-15a-5p GOLPH3L 0.78 0 -0.81 0 miRNAWalker2 validate -0.14 0.00344 NA
58 hsa-miR-15a-5p HACE1 0.78 0 -0.64 0 miRNAWalker2 validate -0.21 0 NA
59 hsa-miR-125a-5p HK2 0.22 0.11955 0.21 0.20977 miRNAWalker2 validate; miRTarBase -0.3 0 NA
60 hsa-miR-181b-5p HUWE1 0.97 0 -0.15 0.1034 miRNAWalker2 validate -0.12 0.00057 NA
61 hsa-miR-590-3p ID4 0.22 0.09659 -2.1 0 miRNAWalker2 validate -0.25 0.00091 NA
62 hsa-miR-590-3p IL6ST 0.22 0.09659 -1.52 0 miRNAWalker2 validate -0.29 0.00477 NA
63 hsa-miR-15a-5p JUN 0.78 0 -0.41 0.00529 miRNAWalker2 validate -0.12 0.02488 NA
64 hsa-miR-181b-5p KAT2B 0.97 0 -2.05 0 miRNAWalker2 validate; miRTarBase -0.47 0 NA
65 hsa-miR-15a-5p KIF1A 0.78 0 -1.2 0.01386 miRNAWalker2 validate -0.59 0.00091 NA
66 hsa-miR-125a-5p KLF13 0.22 0.11955 0.39 0.00143 miRNAWalker2 validate -0.13 0.00086 NA
67 hsa-miR-200c-3p KLF9 0.63 0.00013 -1.05 0 miRNAWalker2 validate; miRTarBase -0.26 0 NA
68 hsa-miR-590-3p LIMS1 0.22 0.09659 0.2 0.25634 miRNAWalker2 validate -0.2 0.00035 NA
69 hsa-miR-361-5p LNPEP 0.08 0.31404 -0.46 0.0042 miRNAWalker2 validate -0.18 0.04853 NA
70 hsa-miR-200c-3p LPAR1 0.63 0.00013 -0.68 0.00029 miRNAWalker2 validate -0.21 2.0E-5 NA
71 hsa-miR-125a-5p LYPLA1 0.22 0.11955 0.02 0.85124 miRNAWalker2 validate -0.12 5.0E-5 NA
72 hsa-miR-125a-5p MACF1 0.22 0.11955 0.39 0.00175 miRNAWalker2 validate -0.22 0 NA
73 hsa-miR-125a-5p MAP3K1 0.22 0.11955 -0.68 0 miRNAWalker2 validate -0.24 0 NA
74 hsa-miR-15a-5p MAPK6 0.78 0 0.3 0.03108 miRNAWalker2 validate -0.21 6.0E-5 NA
75 hsa-miR-125a-5p MAPK8 0.22 0.11955 -0.17 0.26866 miRNAWalker2 validate -0.14 0.00351 NA
76 hsa-miR-590-3p MED13L 0.22 0.09659 -0.27 0.02619 miRNAWalker2 validate -0.11 0.00503 NA
77 hsa-miR-15a-5p MN1 0.78 0 0.58 0.0141 miRTarBase -0.49 0 NA
78 hsa-miR-200c-3p MSN 0.63 0.00013 1.12 0 miRNAWalker2 validate; miRTarBase -0.17 1.0E-5 NA
79 hsa-miR-125a-5p MTUS1 0.22 0.11955 -0.71 0 miRNAWalker2 validate -0.16 8.0E-5 26643896 In contrast let-7a-5p 7e-5p 7f-5p miR-125a-5p and 125b-5p may play important roles in CRC carcinogenesis independent from the MTUS1
80 hsa-miR-200c-3p NCAM1 0.63 0.00013 -1.12 0.00266 miRTarBase -0.74 0 NA
81 hsa-miR-590-3p NEDD4 0.22 0.09659 0.28 0.04605 miRNAWalker2 validate -0.11 0.01437 NA
82 hsa-miR-590-3p NEO1 0.22 0.09659 -0.42 0.00567 miRNAWalker2 validate -0.15 0.00304 NA
83 hsa-miR-15a-5p NFKB1 0.78 0 -0.06 0.53294 miRNAWalker2 validate -0.1 0.00332 NA
84 hsa-miR-125a-5p NIN 0.22 0.11955 0.45 0 miRNAWalker2 validate -0.14 0 NA
85 hsa-miR-15a-5p NIPAL2 0.78 0 -0.96 0 miRNAWalker2 validate -0.53 0 NA
86 hsa-miR-125a-5p NR1D2 0.22 0.11955 -0.8 0 miRNAWalker2 validate -0.1 0.01779 NA
87 hsa-miR-181b-5p NR2F1 0.97 0 -0.47 0.04091 miRNAWalker2 validate -0.35 2.0E-5 NA
88 hsa-miR-590-3p NRIP1 0.22 0.09659 0.07 0.66616 miRNAWalker2 validate -0.19 0.0005 NA
89 hsa-miR-361-5p OGDH 0.08 0.31404 -0.44 0 miRNAWalker2 validate -0.13 0.01134 NA
90 hsa-miR-181b-5p OSBPL8 0.97 0 -0.32 0.00159 miRNAWalker2 validate -0.16 2.0E-5 NA
91 hsa-miR-125a-5p OTUB2 0.22 0.11955 -0.13 0.47288 miRNAWalker2 validate -0.2 0.00042 NA
92 hsa-miR-125a-5p PARD6B 0.22 0.11955 -0.45 0.00407 miRNAWalker2 validate -0.11 0.02902 NA
93 hsa-miR-125a-5p PCDHGB2 0.22 0.11955 0.39 0.26819 miRNAWalker2 validate -0.4 0.0003 NA
94 hsa-miR-15a-5p PCF11 0.78 0 -0.65 0 miRNAWalker2 validate -0.11 0.00086 NA
95 hsa-miR-15a-5p PDCD4 0.78 0 -1.3 0 miRNAWalker2 validate -0.13 0.00316 NA
96 hsa-miR-15a-5p PDCD6IP 0.78 0 -0.69 0 miRNAWalker2 validate -0.17 0 NA
97 hsa-miR-181b-5p PDHX 0.97 0 -0.39 0 miRNAWalker2 validate -0.1 0.00031 NA
98 hsa-miR-125a-5p PDPK1 0.22 0.11955 -0.37 0.00067 miRNAWalker2 validate -0.2 0 NA
99 hsa-miR-15a-5p PHKB 0.78 0 -0.82 0 miRNAWalker2 validate -0.23 0 NA
100 hsa-miR-125a-5p PLA2G4F 0.22 0.11955 -1.14 0.00039 miRNAWalker2 validate -0.29 0.00415 NA
101 hsa-miR-125a-5p PLS3 0.22 0.11955 0.4 0.00047 miRNAWalker2 validate -0.18 0 NA
102 hsa-miR-361-5p PPA1 0.08 0.31404 -0.14 0.12841 miRNAWalker2 validate -0.26 0 NA
103 hsa-miR-200c-3p PPM1F 0.63 0.00013 -0.03 0.71909 miRNAWalker2 validate -0.12 0 22144583 MicroRNA 200c represses migration and invasion of breast cancer cells by targeting actin regulatory proteins FHOD1 and PPM1F; We identified FHOD1 and PPM1F direct regulators of the actin cytoskeleton as novel targets of miR-200c; Remarkably expression levels of FHOD1 and PPM1F were inversely correlated with the level of miR-200c in breast cancer cell lines breast cancer patient samples and 58 cancer cell lines of various origins
104 hsa-miR-125a-5p PPP2R5E 0.22 0.11955 0.18 0.07679 miRNAWalker2 validate -0.26 0 NA
105 hsa-miR-125a-5p PRC1 0.22 0.11955 1.35 0 miRNAWalker2 validate -0.16 0.00015 NA
106 hsa-miR-15a-5p PTAR1 0.78 0 -0.01 0.93427 miRNAWalker2 validate -0.14 0.00012 NA
107 hsa-miR-361-5p PTGS1 0.08 0.31404 -0.11 0.65456 miRNAWalker2 validate -0.3 0.03791 NA
108 hsa-miR-200c-3p PTPRD 0.63 0.00013 0.35 0.3389 miRNAWalker2 validate -0.47 0 NA
109 hsa-miR-125a-5p PUM2 0.22 0.11955 -0.02 0.76365 miRNAWalker2 validate -0.1 0 NA
110 hsa-miR-15a-5p PURA 0.78 0 -0.23 0.00119 miRNAWalker2 validate; miRTarBase -0.16 0 NA
111 hsa-miR-361-5p RAB8B 0.08 0.31404 0.45 3.0E-5 miRNAWalker2 validate -0.16 0.00947 NA
112 hsa-miR-125a-5p RALBP1 0.22 0.11955 -0.09 0.38094 miRNAWalker2 validate -0.13 2.0E-5 NA
113 hsa-miR-181b-5p RAP1GAP2 0.97 0 -0.1 0.58891 miRNAWalker2 validate -0.16 0.00927 NA
114 hsa-miR-200c-3p RASSF2 0.63 0.00013 -0.31 0.11473 miRNAWalker2 validate -0.27 0 NA
115 hsa-miR-125a-5p RBAK 0.22 0.11955 0.28 0.00107 miRNAWalker2 validate -0.12 1.0E-5 NA
116 hsa-miR-15a-5p RECK 0.78 0 -0.78 8.0E-5 miRNAWalker2 validate -0.55 0 NA
117 hsa-miR-15a-5p RGPD5 0.78 0 -0.39 0.14845 miRNAWalker2 validate -0.51 0 NA
118 hsa-miR-200c-3p RHOA 0.63 0.00013 -0.39 0 miRNAWalker2 validate -0.1 0 NA
119 hsa-miR-15a-5p RHOT1 0.78 0 -0.28 0.00015 miRNAWalker2 validate -0.13 0 NA
120 hsa-miR-15a-5p RNASEL 0.78 0 -0.25 0.02222 miRNAWalker2 validate -0.17 1.0E-5 NA
121 hsa-miR-181b-5p RPRD1A 0.97 0 -0.26 0.00491 miRNAWalker2 validate -0.24 0 NA
122 hsa-miR-125a-5p RRP1B 0.22 0.11955 0.21 0.00573 miRNAWalker2 validate -0.13 0 NA
123 hsa-miR-15a-5p SEC63 0.78 0 0.02 0.74711 miRNAWalker2 validate -0.12 0 NA
124 hsa-let-7a-3p SENP7 0.1 0.42376 -0.21 0.07484 miRNAWalker2 validate -0.14 0.00054 NA
125 hsa-miR-590-3p SESN3 0.22 0.09659 0.78 0.00057 miRNAWalker2 validate -0.4 0 NA
126 hsa-miR-590-3p SETD7 0.22 0.09659 -0.52 1.0E-5 miRNAWalker2 validate -0.19 0 NA
127 hsa-miR-181b-5p SIRT1 0.97 0 -0.37 8.0E-5 miRNAWalker2 validate; miRTarBase -0.19 0 NA
128 hsa-miR-15a-5p SKAP2 0.78 0 0.65 0 miRNAWalker2 validate -0.11 0.01362 NA
129 hsa-miR-590-3p SKI 0.22 0.09659 -0.12 0.1932 miRNAWalker2 validate -0.11 0.00022 NA
130 hsa-miR-15a-5p SNX6 0.78 0 0.19 0.03624 miRNAWalker2 validate -0.15 0 NA
131 hsa-miR-125a-5p SP1 0.22 0.11955 -0.22 0.00488 miRNAWalker2 validate -0.16 0 NA
132 hsa-miR-125a-5p TDG 0.22 0.11955 0.38 0 miRNAWalker2 validate -0.11 5.0E-5 NA
133 hsa-miR-125a-5p TFRC 0.22 0.11955 1.13 0 miRNAWalker2 validate -0.29 0 NA
134 hsa-miR-200c-3p TIMP2 0.63 0.00013 0.1 0.61306 miRTarBase -0.41 0 NA
135 hsa-miR-15a-5p TMEM214 0.78 0 0.07 0.24142 miRNAWalker2 validate -0.12 0 NA
136 hsa-miR-361-5p TMEM62 0.08 0.31404 -0.61 0 miRNAWalker2 validate -0.19 0.00163 NA
137 hsa-miR-125a-5p TOR1AIP2 0.22 0.11955 -0.15 0.28655 miRNAWalker2 validate -0.38 0 NA
138 hsa-let-7a-3p TRIM33 0.1 0.42376 -0.35 7.0E-5 miRNAWalker2 validate -0.12 0.00012 NA
139 hsa-miR-181b-5p TRRAP 0.97 0 0.14 0.21597 miRNAWalker2 validate -0.12 0.00248 NA
140 hsa-miR-125a-5p TTC30B 0.22 0.11955 -0.03 0.84946 miRNAWalker2 validate -0.18 0.00012 NA
141 hsa-miR-200c-3p TUBB3 0.63 0.00013 1.85 0 miRNAWalker2 validate; miRTarBase -0.14 0.01533 23074172; 23394580 miR-200c increases sensitivity to taxanes in vitro by targeting class III β-tubulin gene TUBB3 a tubulin known to mediate chemoresistance;This study assessed the role of miR-200c as regulator of class III β-tubulin TUBB3 a factor associated with drug-resistance and poor prognosis in ovarian cancer; Crosslinking-coupled affinity purification method and ribonucleic-immunoprecipitation assay were used to characterise the complexes between miR-200c HuR and 3'UTR region of TUBB3 mRNA; Nanofluidic technology and immunohistochemistry were used to analyze the expression of HuR TUBB3 and miR-200c in 220 ovarian cancer patients; In A2780 cells miR-200c targeted TUBB3 3'UTR while a positive correlation was observed between miR-200c and TUBB3 expression in most of the other cell lines; This study suggests a model for the combined regulatory activity of miR-200c and HuR on TUBB3 expression in ovarian cancer
142 hsa-miR-15a-5p UGDH 0.78 0 0.14 0.37043 miRNAWalker2 validate -0.23 4.0E-5 NA
143 hsa-miR-15a-5p UGP2 0.78 0 -0.85 0 miRNAWalker2 validate -0.1 0.00093 NA
144 hsa-miR-361-5p VCP 0.08 0.31404 0.15 0.13327 miRNAWalker2 validate -0.13 0.01389 NA
145 hsa-miR-361-5p WDR36 0.08 0.31404 0.12 0.1557 miRNAWalker2 validate -0.16 0.00073 NA
146 hsa-miR-15a-5p WIPF1 0.78 0 0.63 0.00017 miRNAWalker2 validate -0.16 0.0076 NA
147 hsa-miR-125a-5p YES1 0.22 0.11955 0.37 0.00025 miRNAWalker2 validate -0.13 6.0E-5 NA
148 hsa-miR-125a-5p YOD1 0.22 0.11955 -0.59 3.0E-5 miRNAWalker2 validate -0.16 0.00055 NA
149 hsa-miR-181b-5p ZBTB20 0.97 0 -0.86 1.0E-5 miRNAWalker2 validate -0.3 3.0E-5 NA
150 hsa-miR-181b-5p ZBTB4 0.97 0 -0.39 0 miRNAWalker2 validate -0.1 0.00032 NA

Over-represented Gene Ontology Biological Process

NumGOOverlapSizeP ValueAdj. P Value
1 REGULATION OF PROTEIN MODIFICATION PROCESS 43 1710 2.684e-12 1.249e-08
2 POSITIVE REGULATION OF MOLECULAR FUNCTION 42 1791 4.876e-11 7.563e-08
3 REGULATION OF PHOSPHORUS METABOLIC PROCESS 40 1618 3.263e-11 7.563e-08
4 REGULATION OF CELL DIFFERENTIATION 37 1492 1.985e-10 2.309e-07
5 POSITIVE REGULATION OF RESPONSE TO STIMULUS 42 1929 4.923e-10 3.818e-07
6 CELLULAR RESPONSE TO ORGANIC SUBSTANCE 41 1848 4.814e-10 3.818e-07
7 NEGATIVE REGULATION OF GENE EXPRESSION 36 1493 7.963e-10 5.293e-07
8 POSITIVE REGULATION OF CATALYTIC ACTIVITY 36 1518 1.247e-09 7.252e-07
9 POSITIVE REGULATION OF PROTEIN METABOLIC PROCESS 35 1492 2.973e-09 1.537e-06
10 NEGATIVE REGULATION OF NITROGEN COMPOUND METABOLIC PROCESS 35 1517 4.574e-09 2.128e-06
11 REGULATION OF KINASE ACTIVITY 24 776 8.069e-09 3.129e-06
12 REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 38 1784 7.646e-09 3.129e-06
13 POSITIVE REGULATION OF GENE EXPRESSION 37 1733 1.195e-08 4.278e-06
14 POSITIVE REGULATION OF DEVELOPMENTAL PROCESS 29 1142 1.564e-08 5.198e-06
15 REGULATION OF HYDROLASE ACTIVITY 31 1327 3.155e-08 9.788e-06
16 POSITIVE REGULATION OF PROTEIN MODIFICATION PROCESS 28 1135 5.312e-08 1.545e-05
17 RESPONSE TO ENDOGENOUS STIMULUS 32 1450 6.814e-08 1.774e-05
18 CELLULAR RESPONSE TO ENDOGENOUS STIMULUS 26 1008 7.139e-08 1.774e-05
19 NEGATIVE REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 22 740 7.244e-08 1.774e-05
20 REGULATION OF TRANSFERASE ACTIVITY 25 946 8.309e-08 1.933e-05
21 POSITIVE REGULATION OF MULTICELLULAR ORGANISMAL PROCESS 31 1395 9.763e-08 2.065e-05
22 RHYTHMIC PROCESS 14 298 9.375e-08 2.065e-05
23 POSITIVE REGULATION OF PHOSPHATE METABOLIC PROCESS 26 1036 1.223e-07 2.277e-05
24 POSITIVE REGULATION OF PHOSPHORUS METABOLIC PROCESS 26 1036 1.223e-07 2.277e-05
25 PHOSPHATE CONTAINING COMPOUND METABOLIC PROCESS 38 1977 1.174e-07 2.277e-05
26 REGULATION OF INTRACELLULAR SIGNAL TRANSDUCTION 34 1656 1.382e-07 2.474e-05
27 TISSUE DEVELOPMENT 32 1518 1.939e-07 3.341e-05
28 POSITIVE REGULATION OF CELL COMMUNICATION 32 1532 2.384e-07 3.962e-05
29 POSITIVE REGULATION OF CELL DIFFERENTIATION 22 823 4.485e-07 7.053e-05
30 REGULATION OF CELL PROLIFERATION 31 1496 4.548e-07 7.053e-05
31 POSITIVE REGULATION OF HYDROLASE ACTIVITY 23 905 5.765e-07 8.486e-05
32 REGULATION OF CELL DEVELOPMENT 22 836 5.836e-07 8.486e-05
33 POSITIVE REGULATION OF CELLULAR COMPONENT ORGANIZATION 26 1152 9.34e-07 0.0001317
34 POSITIVE REGULATION OF BIOSYNTHETIC PROCESS 34 1805 1.025e-06 0.0001363
35 RESPONSE TO GROWTH FACTOR 16 475 1.002e-06 0.0001363
36 POSITIVE REGULATION OF INTRACELLULAR SIGNAL TRANSDUCTION 22 876 1.269e-06 0.000164
37 CELLULAR RESPONSE TO HORMONE STIMULUS 17 552 1.543e-06 0.000194
38 REGULATION OF NEURON DIFFERENTIATION 17 554 1.621e-06 0.0001946
39 REGULATION OF MULTICELLULAR ORGANISMAL DEVELOPMENT 32 1672 1.631e-06 0.0001946
40 RESPONSE TO HORMONE 22 893 1.739e-06 0.0002023
41 FAT CELL DIFFERENTIATION 8 106 1.808e-06 0.0002051
42 ENZYME LINKED RECEPTOR PROTEIN SIGNALING PATHWAY 19 689 1.862e-06 0.0002063
43 CELL JUNCTION ORGANIZATION 10 185 1.962e-06 0.0002123
44 REGULATION OF CELLULAR COMPONENT MOVEMENT 20 771 2.483e-06 0.0002626
45 GLAND DEVELOPMENT 14 395 2.737e-06 0.000283
46 NEGATIVE REGULATION OF MOLECULAR FUNCTION 24 1079 3.329e-06 0.0003324
47 POSITIVE REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 23 1004 3.358e-06 0.0003324
48 NEUROGENESIS 28 1402 3.69e-06 0.0003577
49 PROTEIN PHOSPHORYLATION 22 944 4.271e-06 0.0004056
50 POSITIVE REGULATION OF CELL DEVELOPMENT 15 472 4.514e-06 0.0004201
51 POSITIVE REGULATION OF NEURON DIFFERENTIATION 12 306 5.24e-06 0.00046
52 FC RECEPTOR SIGNALING PATHWAY 10 206 5.132e-06 0.00046
53 POSITIVE REGULATION OF CELL MORPHOGENESIS INVOLVED IN DIFFERENTIATION 9 162 5.186e-06 0.00046
54 APOPTOTIC MITOCHONDRIAL CHANGES 6 57 5.344e-06 0.0004605
55 POSITIVE REGULATION OF KINASE ACTIVITY 15 482 5.81e-06 0.0004743
56 LOCOMOTION 24 1114 5.732e-06 0.0004743
57 RESPONSE TO LIPID 21 888 5.767e-06 0.0004743
58 REGULATION OF NERVOUS SYSTEM DEVELOPMENT 19 750 6.346e-06 0.0005091
59 AGING 11 264 7.409e-06 0.0005843
60 CELL JUNCTION ASSEMBLY 8 129 7.855e-06 0.0006091
61 RESPONSE TO OXYGEN CONTAINING COMPOUND 27 1381 8.356e-06 0.0006374
62 PEPTIDYL AMINO ACID MODIFICATION 20 841 9.051e-06 0.0006584
63 REGULATION OF RESPONSE TO STRESS 28 1468 8.789e-06 0.0006584
64 IMMUNE RESPONSE REGULATING CELL SURFACE RECEPTOR SIGNALING PATHWAY 12 323 9.055e-06 0.0006584
65 PHOSPHORYLATION 25 1228 9.539e-06 0.0006829
66 CELL DEATH 22 1001 1.078e-05 0.00076
67 REGULATION OF IMMUNE SYSTEM PROCESS 27 1403 1.112e-05 0.0007726
68 REGULATION OF IMMUNE RESPONSE 20 858 1.212e-05 0.0008282
69 NEGATIVE REGULATION OF PROTEIN METABOLIC PROCESS 23 1087 1.228e-05 0.0008282
70 POSITIVE REGULATION OF LIPASE ACTIVITY 6 66 1.263e-05 0.0008395
71 REGULATION OF CELLULAR RESPONSE TO GROWTH FACTOR STIMULUS 10 229 1.299e-05 0.000851
72 REGULATION OF CELL MORPHOGENESIS INVOLVED IN DIFFERENTIATION 12 337 1.384e-05 0.0008946
73 POSITIVE REGULATION OF IMMUNE SYSTEM PROCESS 20 867 1.409e-05 0.0008983
74 CELLULAR RESPONSE TO LIPID 14 457 1.438e-05 0.0009041
75 EPITHELIUM DEVELOPMENT 21 945 1.479e-05 0.0009179
76 REGULATION OF MAPK CASCADE 17 660 1.631e-05 0.0009985
77 MOVEMENT OF CELL OR SUBCELLULAR COMPONENT 25 1275 1.805e-05 0.001091
78 REGULATION OF PROTEIN SERINE THREONINE KINASE ACTIVITY 14 470 1.963e-05 0.001171
79 RESPONSE TO OXIDATIVE STRESS 12 352 2.13e-05 0.001255
80 NEGATIVE REGULATION OF PHOSPHORUS METABOLIC PROCESS 15 541 2.268e-05 0.001287
81 CELLULAR RESPONSE TO KETONE 6 73 2.262e-05 0.001287
82 NEGATIVE REGULATION OF PHOSPHATE METABOLIC PROCESS 15 541 2.268e-05 0.001287
83 NEGATIVE REGULATION OF CELL DIFFERENTIATION 16 609 2.309e-05 0.001295
84 POSITIVE REGULATION OF TRANSFERASE ACTIVITY 16 616 2.652e-05 0.001464
85 POSITIVE REGULATION OF CELL PROJECTION ORGANIZATION 11 303 2.674e-05 0.001464
86 REGULATION OF CELL MORPHOGENESIS 15 552 2.861e-05 0.001548
87 RESPONSE TO ORGANIC CYCLIC COMPOUND 20 917 3.138e-05 0.001678
88 RESPONSE TO STEROID HORMONE 14 497 3.621e-05 0.001893
89 POSITIVE REGULATION OF IMMUNE RESPONSE 15 563 3.587e-05 0.001893
90 POSITIVE REGULATION OF NERVOUS SYSTEM DEVELOPMENT 13 437 3.982e-05 0.002059
91 REGULATION OF LIPASE ACTIVITY 6 83 4.705e-05 0.002406
92 CELLULAR RESPONSE TO OXYGEN CONTAINING COMPOUND 18 799 5.313e-05 0.002687
93 CELLULAR RESPONSE TO STEROID HORMONE STIMULUS 9 218 5.499e-05 0.002751
94 POSITIVE REGULATION OF PHOSPHOLIPASE ACTIVITY 5 53 5.744e-05 0.002844
95 RESPONSE TO UV 7 126 5.964e-05 0.002921
96 RESPONSE TO CORTICOSTEROID 8 176 7.357e-05 0.003566
97 CELLULAR RESPONSE TO ORGANIC CYCLIC COMPOUND 13 465 7.487e-05 0.003591
98 REGULATION OF NEURON PROJECTION DEVELOPMENT 12 408 8.853e-05 0.004169
99 POSITIVE REGULATION OF NEURON PROJECTION DEVELOPMENT 9 232 8.869e-05 0.004169
100 RESPONSE TO KETONE 8 182 9.299e-05 0.004327
101 POSITIVE REGULATION BY HOST OF VIRAL TRANSCRIPTION 3 12 9.726e-05 0.00448
102 CIRCADIAN RHYTHM 7 137 0.0001012 0.00457
103 RESPONSE TO INORGANIC SUBSTANCE 13 479 0.0001008 0.00457
104 REGULATION OF CELL PROJECTION ORGANIZATION 14 558 0.0001243 0.005382
105 REGULATION OF TRANSFORMING GROWTH FACTOR BETA RECEPTOR SIGNALING PATHWAY 6 99 0.0001261 0.005382
106 REGULATION OF CELLULAR RESPONSE TO TRANSFORMING GROWTH FACTOR BETA STIMULUS 6 99 0.0001261 0.005382
107 MESENCHYME DEVELOPMENT 8 190 0.0001253 0.005382
108 NEGATIVE REGULATION OF PHOSPHORYLATION 12 422 0.0001216 0.005382
109 POSITIVE REGULATION OF PHOSPHATIDYLINOSITOL 3 KINASE SIGNALING 5 62 0.0001224 0.005382
110 RESPONSE TO WOUNDING 14 563 0.0001364 0.005704
111 ACTIVATION OF IMMUNE RESPONSE 12 427 0.0001357 0.005704
112 REGULATION OF ANATOMICAL STRUCTURE MORPHOGENESIS 20 1021 0.0001373 0.005704
113 REGULATION OF PHOSPHOLIPASE ACTIVITY 5 64 0.0001425 0.005866
114 TRANSMEMBRANE RECEPTOR PROTEIN TYROSINE KINASE SIGNALING PATHWAY 13 498 0.0001481 0.006045
115 REGULATION OF AUTOPHAGY 9 249 0.0001515 0.006129
116 NEGATIVE REGULATION OF KINASE ACTIVITY 9 250 0.0001561 0.006262
117 NEGATIVE REGULATION OF CELL DEATH 18 872 0.0001599 0.00636
118 POSITIVE REGULATION OF ORGANELLE ORGANIZATION 14 573 0.0001637 0.006457
119 REGULATION OF FAT CELL DIFFERENTIATION 6 106 0.0001836 0.007117
120 REGULATION OF CELL DEATH 25 1472 0.0001833 0.007117
121 RESPONSE TO NERVE GROWTH FACTOR 4 37 0.0001925 0.007402
122 POSITIVE REGULATION OF AXONOGENESIS 5 69 0.0002035 0.007762
123 RESPONSE TO INSULIN 8 205 0.000211 0.00798
124 INTERSPECIES INTERACTION BETWEEN ORGANISMS 15 662 0.0002162 0.00798
125 REGULATION OF MEMBRANE PERMEABILITY 5 70 0.0002178 0.00798
126 SYMBIOSIS ENCOMPASSING MUTUALISM THROUGH PARASITISM 15 662 0.0002162 0.00798
127 RESPONSE TO HYDROGEN PEROXIDE 6 109 0.0002138 0.00798
128 REGULATION OF TRANSMEMBRANE RECEPTOR PROTEIN SERINE THREONINE KINASE SIGNALING PATHWAY 8 207 0.0002254 0.008192
129 PROTEIN ACYLATION 7 159 0.0002543 0.009172
130 NEGATIVE REGULATION OF CATALYTIC ACTIVITY 17 829 0.0002651 0.009487
NumGOOverlapSizeP ValueAdj. P Value
1 ENZYME BINDING 42 1737 1.842e-11 1.711e-08
2 IDENTICAL PROTEIN BINDING 32 1209 8.807e-10 4.091e-07
3 SMAD BINDING 8 72 8.973e-08 2.779e-05
4 TRANSCRIPTION FACTOR BINDING 18 524 1.511e-07 3.509e-05
5 KINASE BINDING 18 606 1.248e-06 0.0002319
6 PROTEIN HOMODIMERIZATION ACTIVITY 19 722 3.678e-06 0.0004881
7 TRANSCRIPTION FACTOR ACTIVITY PROTEIN BINDING 17 588 3.607e-06 0.0004881
8 PROTEIN DIMERIZATION ACTIVITY 24 1149 9.629e-06 0.001118
9 MOLECULAR FUNCTION REGULATOR 26 1353 1.701e-05 0.001756
10 PROTEIN DOMAIN SPECIFIC BINDING 16 624 3.098e-05 0.002616
11 MACROMOLECULAR COMPLEX BINDING 26 1399 3.019e-05 0.002616
12 RNA POLYMERASE II TRANSCRIPTION FACTOR ACTIVITY SEQUENCE SPECIFIC DNA BINDING 16 629 3.41e-05 0.00264
13 PROTEIN KINASE ACTIVITY 16 640 4.194e-05 0.002997
14 ENZYME REGULATOR ACTIVITY 20 959 5.86e-05 0.003889
15 KINASE ACTIVITY 18 842 0.0001034 0.006405
16 RNA POLYMERASE II TRANSCRIPTION FACTOR BINDING 6 104 0.0001654 0.009602
NumGOOverlapSizeP ValueAdj. P Value
1 CELL SUBSTRATE JUNCTION 14 398 2.988e-06 0.001745
2 ANCHORING JUNCTION 15 489 6.905e-06 0.002016

Over-represented Pathway

NumPathwayPathviewOverlapSizeP ValueAdj. P Value
1 Focal_adhesion_hsa04510 13 199 5.671e-09 2.949e-07
2 MAPK_signaling_pathway_hsa04010 14 295 8.275e-08 2.151e-06
3 Tight_junction_hsa04530 10 170 9.103e-07 1.235e-05
4 FoxO_signaling_pathway_hsa04068 9 132 9.5e-07 1.235e-05
5 HIF_1_signaling_pathway_hsa04066 7 100 1.339e-05 0.0001392
6 PI3K_Akt_signaling_pathway_hsa04151 12 352 2.13e-05 0.0001846
7 Rap1_signaling_pathway_hsa04015 9 206 3.54e-05 0.000255
8 Sphingolipid_signaling_pathway_hsa04071 7 118 3.923e-05 0.000255
9 AMPK_signaling_pathway_hsa04152 7 121 4.607e-05 0.0002662
10 ErbB_signaling_pathway_hsa04012 6 85 5.382e-05 0.0002799
11 Apoptosis_hsa04210 7 138 0.0001059 0.0005005
12 Mitophagy_animal_hsa04137 5 65 0.0001534 0.0006646
13 Ras_signaling_pathway_hsa04014 8 232 0.0004837 0.001891
14 TGF_beta_signaling_pathway_hsa04350 5 84 0.0005091 0.001891
15 cAMP_signaling_pathway_hsa04024 7 198 0.0009427 0.003268
16 Wnt_signaling_pathway_hsa04310 6 146 0.001011 0.003286
17 Regulation_of_actin_cytoskeleton_hsa04810 7 208 0.001254 0.003837
18 TNF_signaling_pathway_hsa04668 5 108 0.001583 0.004426
19 Cellular_senescence_hsa04218 6 160 0.001617 0.004426
20 Adherens_junction_hsa04520 4 72 0.002428 0.006312
21 Endocytosis_hsa04144 7 244 0.003088 0.007647
22 Hedgehog_signaling_pathway_hsa04340 3 47 0.005871 0.01388
23 Jak_STAT_signaling_pathway_hsa04630 5 162 0.008884 0.02008
24 Autophagy_animal_hsa04140 4 128 0.01803 0.03906
25 Signaling_pathways_regulating_pluripotency_of_stem_cells_hsa04550 4 139 0.02358 0.04905
26 Apoptosis_multiple_species_hsa04215 2 33 0.02725 0.05315
27 Phospholipase_D_signaling_pathway_hsa04072 4 146 0.0276 0.05315
28 mTOR_signaling_pathway_hsa04150 4 151 0.0307 0.05621
29 Phagosome_hsa04145 4 152 0.03135 0.05621
30 Hippo_signaling_pathway_hsa04390 4 154 0.03266 0.05662
31 Ferroptosis_hsa04216 2 40 0.03886 0.06333
32 cGMP_PKG_signaling_pathway_hsa04022 4 163 0.03897 0.06333
33 Notch_signaling_pathway_hsa04330 2 48 0.05399 0.08508
34 VEGF_signaling_pathway_hsa04370 2 59 0.07753 0.1186
35 p53_signaling_pathway_hsa04115 2 68 0.09873 0.1467
36 Cell_adhesion_molecules_.CAMs._hsa04514 3 145 0.1045 0.151
37 Necroptosis_hsa04217 3 164 0.1368 0.1923
38 Gap_junction_hsa04540 2 88 0.1504 0.2058
39 NF_kappa_B_signaling_pathway_hsa04064 2 95 0.1696 0.2211
40 Calcium_signaling_pathway_hsa04020 3 182 0.17 0.2211
41 Cell_cycle_hsa04110 2 124 0.2521 0.3048
42 Oocyte_meiosis_hsa04114 2 124 0.2521 0.3048
43 Apelin_signaling_pathway_hsa04371 2 137 0.2896 0.3423
44 Cytokine_cytokine_receptor_interaction_hsa04060 3 270 0.3523 0.4071
45 Neuroactive_ligand_receptor_interaction_hsa04080 2 278 0.6408 0.6942

Quest ID: 1e7721a12892593c68117cafb73aad50