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This regulatory network was inferred from the input dataset. The miRNAs and mRNAs are presented as round and rectangle nodes respectively. The numerical value popped up upon mouse over the gene node is the log2 transformed fold-change of the gene expression between the two groups. All of the nodes are clickable, and the detailed information of the miRNAs/mRNAs and related cancer pathway will be displayed in another window. The edges between nodes are supported by both interactions (predicted or experimentally verified) and correlations learnt from cancer dataset. The numerical value popped up upon mouse over the edge is the correlation beat value (effect size) between the two nodes. The experimental evidences of the edges reported in previous cancer studies are highlighted by red/orange color. All of these information can be accessed by the "mouse-over" action. This network shows a full map of the miRNA-mRNA regulation of the input gene list(s), and the hub miRNAs (with the high network degree/betweenness centrality) would be the potential cancer drivers or tumor suppressors. The full result table can be accessed in the "Regulations" tab.

"miRNACancerMAP" is also a network visualization tool for users to draw their regulatory network by personal customization. Users can set the complexity of the network by limiting the number of nodes or edges. And the color of the nodes can be defined by different categories of the mRNAs and miRNAs, such as Gene-Ontology, pathway, and expression status. Users can also select to use network degree or network betweenness centrality to define the node size. And edges can be black or colored by the correlation. Purple edge means negative correlation (mostly found between miRNA and mRNA), and blue edge means positive correlation (found in PPI or miRNA-miRNA sponge effect). We can also add the protein-protein interactions (PPI) into the network. This result will show the cluster of genes regulated by some specific miRNAs. Additionally, miRNA-miRNA edges can be added by the "miRNA sponge" button, presenting some clusters of miRNAs that have the interactions via sponge effect.

miRNA-gene regulations

(Download full result)

Num microRNA           Gene miRNA log2FC miRNA pvalue Gene log2FC Gene pvalue Interaction Correlation beta Correlation P-value PMID Reported in cancer studies
1 hsa-miR-130a-3p NRP1 -0.01 0.93453 0.11 0.41779 miRNATAP -0.18 0.00023 26573160 NRP1 is targeted by miR 130a and miR 130b and is associated with multidrug resistance in epithelial ovarian cancer based on integrated gene network analysis
2 hsa-miR-133b NRP1 -1.64 0 0.11 0.41779 miRanda -0.15 0 NA
3 hsa-miR-139-5p NRP1 -0.25 0.04065 0.11 0.41779 PITA; miRanda -0.14 0.00259 NA
4 hsa-miR-141-3p NRP1 1.8 0 0.11 0.41779 TargetScan; miRNATAP -0.12 0.00065 NA
5 hsa-miR-148a-3p NRP1 1.85 0 0.11 0.41779 miRNATAP -0.2 0 26967387 Mechanistically miR-148a appears to suppress the extravasation process of cancer cells likely by targeting two genes WNT1 and NRP1 in a cell non-autonomous manner
6 hsa-miR-186-5p NRP1 0.57 0 0.11 0.41779 miRNAWalker2 validate; mirMAP; miRNATAP -0.19 0.00921 NA
7 hsa-miR-214-3p NRP1 0.25 0.05575 0.11 0.41779 miRNATAP -0.15 0.00097 NA
8 hsa-miR-30a-5p NRP1 0.51 0 0.11 0.41779 mirMAP; miRNATAP -0.19 0.00027 NA
9 hsa-miR-30b-5p NRP1 1.17 0 0.11 0.41779 mirMAP -0.13 0.00248 NA
10 hsa-miR-30c-5p NRP1 0.75 0 0.11 0.41779 mirMAP; miRNATAP -0.29 0 NA
11 hsa-miR-30e-5p NRP1 -0.04 0.61092 0.11 0.41779 mirMAP -0.23 0.00128 NA
12 hsa-miR-320a NRP1 1 0 0.11 0.41779 PITA; miRanda; miRNATAP -0.12 0.01833 22134529 miR-320a directly binds to the 3'UTR of neuropilin 1 NRP-1 a protein that functions as a co-receptor of vascular epithelial growth factor
13 hsa-miR-324-5p NRP1 0.54 2.0E-5 0.11 0.41779 miRanda -0.12 0.00975 NA
14 hsa-miR-361-5p NRP1 0.65 0 0.11 0.41779 miRanda; miRNATAP -0.36 1.0E-5 NA
15 hsa-miR-374a-3p NRP1 0.61 0 0.11 0.41779 miRNATAP -0.14 0.02516 NA
16 hsa-miR-582-5p NRP1 0.31 0.04027 0.11 0.41779 PITA; miRNATAP -0.15 7.0E-5 NA
17 hsa-miR-590-3p NRP1 0.58 0 0.11 0.41779 PITA; miRanda; mirMAP -0.1 0.02839 NA
18 hsa-miR-590-5p NRP1 0.78 0 0.11 0.41779 miRanda -0.12 0.00685 NA
19 hsa-miR-664a-3p NRP1 0.77 0 0.11 0.41779 mirMAP -0.21 0.00023 NA

Over-represented Gene Ontology Biological Process

NumGOOverlapSizeP ValueAdj. P Value
1 REGULATION OF CELLULAR COMPONENT MOVEMENT 15 771 2.291e-12 1.066e-08
2 NEGATIVE REGULATION OF NERVOUS SYSTEM DEVELOPMENT 10 262 3.2e-11 7.444e-08
3 NEGATIVE REGULATION OF CELL DEVELOPMENT 10 303 1.333e-10 1.55e-07
4 REGULATION OF ANATOMICAL STRUCTURE MORPHOGENESIS 15 1021 1.224e-10 1.55e-07
5 REGULATION OF NEURON DIFFERENTIATION 12 554 1.786e-10 1.662e-07
6 REGULATION OF NERVOUS SYSTEM DEVELOPMENT 13 750 4.054e-10 3.073e-07
7 TAXIS 11 464 4.623e-10 3.073e-07
8 RESPONSE TO EXTERNAL STIMULUS 18 1821 5.563e-10 3.235e-07
9 NEGATIVE REGULATION OF LOCOMOTION 9 263 9.25e-10 4.782e-07
10 REGULATION OF MULTICELLULAR ORGANISMAL DEVELOPMENT 17 1672 1.383e-09 6.434e-07
11 REGULATION OF CELL DEVELOPMENT 13 836 1.522e-09 6.439e-07
12 MESENCHYME DEVELOPMENT 8 190 1.746e-09 6.769e-07
13 NEGATIVE REGULATION OF CELLULAR COMPONENT ORGANIZATION 12 684 1.967e-09 7.039e-07
14 REGULATION OF NEURON PROJECTION DEVELOPMENT 10 408 2.383e-09 7.92e-07
15 REGULATION OF CELL PROJECTION ORGANIZATION 11 558 3.202e-09 8.763e-07
16 NEURON PROJECTION GUIDANCE 8 205 3.179e-09 8.763e-07
17 TISSUE DEVELOPMENT 16 1518 3.121e-09 8.763e-07
18 CELLULAR COMPONENT MORPHOGENESIS 13 900 3.713e-09 9.598e-07
19 MESENCHYMAL CELL DIFFERENTIATION 7 134 4.507e-09 1.085e-06
20 LOCOMOTION 14 1114 4.663e-09 1.085e-06
21 SEMAPHORIN PLEXIN SIGNALING PATHWAY 5 36 5.916e-09 1.311e-06
22 NEGATIVE REGULATION OF DEVELOPMENTAL GROWTH 6 84 9.59e-09 1.801e-06
23 NEUROGENESIS 15 1402 9.677e-09 1.801e-06
24 CARDIOVASCULAR SYSTEM DEVELOPMENT 12 788 9.621e-09 1.801e-06
25 CIRCULATORY SYSTEM DEVELOPMENT 12 788 9.621e-09 1.801e-06
26 NEGATIVE REGULATION OF MULTICELLULAR ORGANISMAL PROCESS 13 983 1.069e-08 1.914e-06
27 CELL PART MORPHOGENESIS 11 633 1.184e-08 1.967e-06
28 NEGATIVE REGULATION OF DEVELOPMENTAL PROCESS 12 801 1.154e-08 1.967e-06
29 CELL MORPHOGENESIS INVOLVED IN NEURON DIFFERENTIATION 9 368 1.731e-08 2.778e-06
30 CELL MORPHOGENESIS INVOLVED IN DIFFERENTIATION 10 513 2.112e-08 3.276e-06
31 REGULATION OF CELL SIZE 7 172 2.55e-08 3.828e-06
32 NEURON DIFFERENTIATION 12 874 3.035e-08 4.324e-06
33 NEGATIVE REGULATION OF RESPONSE TO EXTERNAL STIMULUS 8 274 3.067e-08 4.324e-06
34 GLAND DEVELOPMENT 9 395 3.185e-08 4.358e-06
35 NEURON PROJECTION DEVELOPMENT 10 545 3.736e-08 4.698e-06
36 NEURAL CREST CELL MIGRATION 5 51 3.613e-08 4.698e-06
37 NEURON PROJECTION MORPHOGENESIS 9 402 3.703e-08 4.698e-06
38 RESPONSE TO WOUNDING 10 563 5.068e-08 6.047e-06
39 STEM CELL DIFFERENTIATION 7 190 5.058e-08 6.047e-06
40 NEGATIVE REGULATION OF NEURON DIFFERENTIATION 7 191 5.243e-08 6.099e-06
41 POSITIVE REGULATION OF LOCOMOTION 9 420 5.388e-08 6.115e-06
42 POSITIVE REGULATION OF DEVELOPMENTAL PROCESS 13 1142 6.31e-08 6.991e-06
43 POSITIVE REGULATION OF MULTICELLULAR ORGANISMAL PROCESS 14 1395 8.039e-08 8.699e-06
44 CELL DEVELOPMENT 14 1426 1.057e-07 1.093e-05
45 NEGATIVE REGULATION OF CELL DIFFERENTIATION 10 609 1.056e-07 1.093e-05
46 NEGATIVE REGULATION OF AXONOGENESIS 5 65 1.247e-07 1.261e-05
47 HEART DEVELOPMENT 9 466 1.306e-07 1.293e-05
48 NEGATIVE REGULATION OF AXON GUIDANCE 4 27 1.687e-07 1.635e-05
49 REGULATION OF CELL DIFFERENTIATION 14 1492 1.852e-07 1.759e-05
50 ORGAN MORPHOGENESIS 11 841 2.134e-07 1.986e-05
51 NEGATIVE REGULATION OF CELL PROJECTION ORGANIZATION 6 144 2.427e-07 2.214e-05
52 RESPONSE TO ALCOHOL 8 362 2.603e-07 2.286e-05
53 NEURAL CREST CELL DIFFERENTIATION 5 75 2.571e-07 2.286e-05
54 CENTRAL NERVOUS SYSTEM DEVELOPMENT 11 872 3.066e-07 2.642e-05
55 NEURON DEVELOPMENT 10 687 3.222e-07 2.725e-05
56 AMEBOIDAL TYPE CELL MIGRATION 6 154 3.608e-07 2.998e-05
57 TISSUE MORPHOGENESIS 9 533 4.054e-07 3.31e-05
58 HEAD DEVELOPMENT 10 709 4.304e-07 3.394e-05
59 CELL PROJECTION ORGANIZATION 11 902 4.296e-07 3.394e-05
60 NEGATIVE REGULATION OF RESPONSE TO STIMULUS 13 1360 4.787e-07 3.712e-05
61 REGULATION OF RESPONSE TO EXTERNAL STIMULUS 11 926 5.576e-07 4.253e-05
62 REGULATION OF AXONOGENESIS 6 168 6.019e-07 4.517e-05
63 MUSCLE TISSUE DEVELOPMENT 7 275 6.229e-07 4.6e-05
64 NEGATIVE REGULATION OF AXON EXTENSION 4 38 6.994e-07 5.085e-05
65 ANATOMICAL STRUCTURE FORMATION INVOLVED IN MORPHOGENESIS 11 957 7.724e-07 5.487e-05
66 REGULATION OF AXON GUIDANCE 4 39 7.783e-07 5.487e-05
67 REGULATION OF DEVELOPMENTAL GROWTH 7 289 8.689e-07 6.034e-05
68 RHYTHMIC PROCESS 7 298 1.067e-06 7.298e-05
69 REGULATION OF EXTENT OF CELL GROWTH 5 101 1.14e-06 7.685e-05
70 REGIONALIZATION 7 311 1.418e-06 9.292e-05
71 REGULATION OF CELL PROLIFERATION 13 1496 1.414e-06 9.292e-05
72 POSITIVE REGULATION OF CELL PROLIFERATION 10 814 1.512e-06 9.774e-05
73 MOVEMENT OF CELL OR SUBCELLULAR COMPONENT 12 1275 1.781e-06 0.0001135
74 CELL MOTILITY 10 835 1.903e-06 0.000118
75 LOCALIZATION OF CELL 10 835 1.903e-06 0.000118
76 OVULATION CYCLE 5 113 1.987e-06 0.0001217
77 REGULATION OF CELL MORPHOGENESIS INVOLVED IN DIFFERENTIATION 7 337 2.416e-06 0.0001405
78 REGULATION OF CELLULAR COMPONENT SIZE 7 337 2.416e-06 0.0001405
79 NEGATIVE REGULATION OF CELL MORPHOGENESIS INVOLVED IN DIFFERENTIATION 5 117 2.36e-06 0.0001405
80 NEGATIVE REGULATION OF CHEMOTAXIS 4 51 2.327e-06 0.0001405
81 RESPONSE TO STEROID HORMONE 8 497 2.815e-06 0.0001617
82 CARDIAC RIGHT VENTRICLE MORPHOGENESIS 3 16 3.21e-06 0.00018
83 BRANCHING INVOLVED IN SALIVARY GLAND MORPHOGENESIS 3 16 3.21e-06 0.00018
84 FOREBRAIN DEVELOPMENT 7 357 3.535e-06 0.0001935
85 EMBRYO DEVELOPMENT 10 894 3.508e-06 0.0001935
86 ANATOMICAL STRUCTURE ARRANGEMENT 3 17 3.893e-06 0.0002106
87 REGULATION OF VASCULATURE DEVELOPMENT 6 233 4.029e-06 0.0002155
88 NEGATIVE REGULATION OF GROWTH 6 236 4.336e-06 0.0002293
89 RESPONSE TO ORGANIC CYCLIC COMPOUND 10 917 4.398e-06 0.0002299
90 RETINAL GANGLION CELL AXON GUIDANCE 3 18 4.666e-06 0.0002412
91 KIDNEY VASCULATURE DEVELOPMENT 3 19 5.534e-06 0.0002799
92 RENAL SYSTEM VASCULATURE DEVELOPMENT 3 19 5.534e-06 0.0002799
93 TUBE DEVELOPMENT 8 552 6.099e-06 0.0003019
94 REGULATION OF CELL MORPHOGENESIS 8 552 6.099e-06 0.0003019
95 RESPONSE TO ESTRADIOL 5 146 6.989e-06 0.0003423
96 MORPHOGENESIS OF AN EPITHELIUM 7 400 7.45e-06 0.0003611
97 GROWTH 7 410 8.75e-06 0.0004197
98 PATTERN SPECIFICATION PROCESS 7 418 9.922e-06 0.0004711
99 CELLULAR RESPONSE TO CARBOHYDRATE STIMULUS 4 74 1.04e-05 0.0004886
100 CELLULAR GLUCOSE HOMEOSTASIS 4 75 1.097e-05 0.0005103
101 RESPONSE TO ABIOTIC STIMULUS 10 1024 1.163e-05 0.000536
102 MUSCLE STRUCTURE DEVELOPMENT 7 432 1.229e-05 0.0005497
103 RESPONSE TO DRUG 7 431 1.21e-05 0.0005497
104 DIENCEPHALON DEVELOPMENT 4 77 1.218e-05 0.0005497
105 REGULATION OF EPITHELIAL CELL PROLIFERATION 6 285 1.274e-05 0.0005645
106 REGULATION OF EPITHELIAL CELL MIGRATION 5 166 1.304e-05 0.0005724
107 MORPHOGENESIS OF A BRANCHING STRUCTURE 5 167 1.342e-05 0.0005837
108 RESPONSE TO CARBOHYDRATE 5 168 1.382e-05 0.0005953
109 POSITIVE REGULATION OF CELL DIFFERENTIATION 9 823 1.426e-05 0.0006087
110 ANGIOGENESIS 6 293 1.49e-05 0.0006304
111 NEGATIVE REGULATION OF NEURON DEATH 5 171 1.505e-05 0.0006309
112 REGULATION OF GROWTH 8 633 1.651e-05 0.0006858
113 NEGATIVE REGULATION OF CELL PROLIFERATION 8 643 1.848e-05 0.000761
114 REGULATION OF CHEMOTAXIS 5 180 1.928e-05 0.0007868
115 RESPONSE TO KETONE 5 182 2.033e-05 0.0008225
116 RESPONSE TO ARSENIC CONTAINING SUBSTANCE 3 29 2.06e-05 0.0008264
117 VASCULATURE DEVELOPMENT 7 469 2.087e-05 0.0008301
118 REGULATION OF ANATOMICAL STRUCTURE SIZE 7 472 2.174e-05 0.0008432
119 SEGMENTATION 4 89 2.163e-05 0.0008432
120 POSITIVE REGULATION OF CELL DEVELOPMENT 7 472 2.174e-05 0.0008432
121 POSITIVE REGULATION OF INTRACELLULAR SIGNAL TRANSDUCTION 9 876 2.341e-05 0.0009002
122 RESPONSE TO ACID CHEMICAL 6 319 2.407e-05 0.0009181
123 REGULATION OF INTRACELLULAR SIGNAL TRANSDUCTION 12 1656 2.607e-05 0.0009752
124 RESPONSE TO OXYGEN CONTAINING COMPOUND 11 1381 2.62e-05 0.0009752
125 RESPONSE TO LIPID 9 888 2.607e-05 0.0009752
126 SALIVARY GLAND DEVELOPMENT 3 32 2.786e-05 0.001021
127 ENDOCARDIAL CUSHION DEVELOPMENT 3 32 2.786e-05 0.001021
128 NEURON RECOGNITION 3 33 3.061e-05 0.00108
129 GLAND MORPHOGENESIS 4 97 3.037e-05 0.00108
130 ENZYME LINKED RECEPTOR PROTEIN SIGNALING PATHWAY 8 689 3.033e-05 0.00108
131 RESPIRATORY SYSTEM DEVELOPMENT 5 197 2.973e-05 0.00108
132 DEVELOPMENTAL GROWTH 6 333 3.063e-05 0.00108
133 POSITIVE REGULATION OF EPITHELIAL CELL MIGRATION 4 103 3.845e-05 0.001345
134 POSITIVE CHEMOTAXIS 3 36 3.99e-05 0.001385
135 RESPONSE TO ENDOGENOUS STIMULUS 11 1450 4.115e-05 0.001418
136 EPITHELIUM DEVELOPMENT 9 945 4.248e-05 0.001453
137 NEGATIVE REGULATION OF GLIOGENESIS 3 37 4.337e-05 0.001473
138 DEVELOPMENT OF PRIMARY SEXUAL CHARACTERISTICS 5 216 4.615e-05 0.001556
139 REGULATION OF CELL DEATH 11 1472 4.726e-05 0.001582
140 RESPONSE TO ESTROGEN 5 218 4.821e-05 0.001602
141 BLOOD VESSEL MORPHOGENESIS 6 364 5.033e-05 0.001655
142 NEGATIVE CHEMOTAXIS 3 39 5.088e-05 0.001655
143 NEGATIVE REGULATION OF MITOCHONDRION ORGANIZATION 3 39 5.088e-05 0.001655
144 NEGATIVE REGULATION OF EPITHELIAL CELL PROLIFERATION 4 115 5.917e-05 0.001912
145 CELL CELL SIGNALING 8 767 6.482e-05 0.00208
146 POSITIVE REGULATION OF CELL COMMUNICATION 11 1532 6.81e-05 0.002164
147 CRANIAL NERVE DEVELOPMENT 3 43 6.835e-05 0.002164
148 REGULATION OF CELL GROWTH 6 391 7.479e-05 0.002351
149 CELLULAR RESPONSE TO ORGANIC SUBSTANCE 12 1848 7.7e-05 0.002404
150 EXOCRINE SYSTEM DEVELOPMENT 3 45 7.839e-05 0.002432
151 REGULATION OF ORGAN MORPHOGENESIS 5 242 7.908e-05 0.002437
152 EMBRYONIC ORGAN DEVELOPMENT 6 406 9.202e-05 0.002817
153 RESPONSE TO AXON INJURY 3 48 9.519e-05 0.002854
154 REPRODUCTIVE SYSTEM DEVELOPMENT 6 408 9.453e-05 0.002854
155 DIGESTIVE TRACT MORPHOGENESIS 3 48 9.519e-05 0.002854
156 REGULATION OF NEURON DEATH 5 252 9.57e-05 0.002854
157 RETINA DEVELOPMENT IN CAMERA TYPE EYE 4 131 9.819e-05 0.00291
158 POSITIVE REGULATION OF CELL DEATH 7 605 0.0001046 0.003081
159 NEGATIVE REGULATION OF NEURON APOPTOTIC PROCESS 4 135 0.0001103 0.003228
160 CELLULAR RESPONSE TO ABIOTIC STIMULUS 5 263 0.000117 0.003401
161 AGING 5 264 0.0001191 0.003441
162 SEX DIFFERENTIATION 5 266 0.0001233 0.003543
163 NEGATIVE REGULATION OF AUTOPHAGY 3 53 0.0001281 0.003657
164 POSITIVE REGULATION OF NERVOUS SYSTEM DEVELOPMENT 6 437 0.0001376 0.003905
165 CARDIAC CHAMBER DEVELOPMENT 4 144 0.0001415 0.003991
166 RESPONSE TO EXTRACELLULAR STIMULUS 6 441 0.0001446 0.004054
167 EMBRYONIC ORGAN MORPHOGENESIS 5 279 0.0001541 0.004295
168 CELLULAR RESPONSE TO LIPID 6 457 0.0001755 0.004862
169 NEGATIVE REGULATION OF GLIAL CELL PROLIFERATION 2 11 0.0001812 0.00499
170 POSITIVE REGULATION OF EPITHELIAL CELL PROLIFERATION 4 154 0.0001832 0.005014
171 POSITIVE REGULATION OF SMOOTH MUSCLE CELL PROLIFERATION 3 60 0.0001855 0.00504
172 RESPONSE TO HORMONE 8 893 0.0001863 0.00504
173 CELLULAR RESPONSE TO ORGANIC CYCLIC COMPOUND 6 465 0.0001928 0.005157
174 NEGATIVE REGULATION OF CELLULAR CATABOLIC PROCESS 4 156 0.0001925 0.005157
175 OVARIAN FOLLICLE DEVELOPMENT 3 61 0.0001948 0.00518
176 CELL PROLIFERATION 7 672 0.0002003 0.005295
177 WOUND HEALING 6 470 0.0002043 0.005345
178 CARDIAC VENTRICLE MORPHOGENESIS 3 62 0.0002045 0.005345
179 UROGENITAL SYSTEM DEVELOPMENT 5 299 0.0002127 0.005529
180 NEURON PROJECTION EXTENSION INVOLVED IN NEURON PROJECTION GUIDANCE 2 12 0.0002172 0.005554
181 AXON EXTENSION INVOLVED IN AXON GUIDANCE 2 12 0.0002172 0.005554
182 HEART FORMATION 2 12 0.0002172 0.005554
183 RESPONSE TO INORGANIC SUBSTANCE 6 479 0.0002263 0.005724
184 POSITIVE REGULATION OF CELL PROJECTION ORGANIZATION 5 303 0.0002262 0.005724
185 POSITIVE REGULATION OF NEURON DIFFERENTIATION 5 306 0.0002367 0.005954
186 CENTRAL NERVOUS SYSTEM NEURON DIFFERENTIATION 4 166 0.0002441 0.006107
187 NEGATIVE REGULATION OF CELL COMMUNICATION 9 1192 0.0002508 0.006242
188 CELLULAR RESPONSE TO THYROID HORMONE STIMULUS 2 13 0.0002564 0.006247
189 SEMAPHORIN PLEXIN SIGNALING PATHWAY INVOLVED IN NEURON PROJECTION GUIDANCE 2 13 0.0002564 0.006247
190 MESENCHYMAL CELL PROLIFERATION 2 13 0.0002564 0.006247
191 GANGLION DEVELOPMENT 2 13 0.0002564 0.006247
192 NEGATIVE REGULATION OF CELL GROWTH 4 170 0.0002674 0.006348
193 GLUCOSE HOMEOSTASIS 4 170 0.0002674 0.006348
194 MULTICELLULAR ORGANISMAL RESPONSE TO STRESS 3 68 0.0002689 0.006348
195 ORGAN GROWTH 3 68 0.0002689 0.006348
196 NERVE DEVELOPMENT 3 68 0.0002689 0.006348
197 CARBOHYDRATE HOMEOSTASIS 4 170 0.0002674 0.006348
198 EPITHELIAL CELL DIFFERENTIATION 6 495 0.0002701 0.006348
199 REGULATION OF CELL SUBSTRATE ADHESION 4 173 0.0002858 0.006682
200 CENTRAL NERVOUS SYSTEM NEURON DEVELOPMENT 3 70 0.0002929 0.006815
201 SPECIFICATION OF ORGAN IDENTITY 2 14 0.0002988 0.006883
202 ATRIAL SEPTUM MORPHOGENESIS 2 14 0.0002988 0.006883
203 REGULATION OF SYSTEM PROCESS 6 507 0.0003071 0.007039
204 BLASTODERM SEGMENTATION 2 15 0.0003444 0.007817
205 REGULATION OF CELL PROLIFERATION INVOLVED IN HEART MORPHOGENESIS 2 15 0.0003444 0.007817
206 DEVELOPMENTAL CELL GROWTH 3 77 0.000388 0.008764
207 REGULATION OF MEMBRANE POTENTIAL 5 343 0.0004001 0.008994
208 RESPONSE TO NUTRIENT 4 191 0.000416 0.009306
209 DENDRITE DEVELOPMENT 3 79 0.0004184 0.009314
210 REGULATION OF NEURON APOPTOTIC PROCESS 4 192 0.0004243 0.009357
211 CELLULAR RESPONSE TO ENDOGENOUS STIMULUS 8 1008 0.0004232 0.009357
212 NEGATIVE REGULATION OF VASCULATURE DEVELOPMENT 3 80 0.0004341 0.009528
213 NEGATIVE REGULATION OF STEM CELL PROLIFERATION 2 17 0.000445 0.009677
214 PARASYMPATHETIC NERVOUS SYSTEM DEVELOPMENT 2 17 0.000445 0.009677
215 MULTICELLULAR ORGANISM REPRODUCTION 7 768 0.0004505 0.009749
NumGOOverlapSizeP ValueAdj. P Value
1 RECEPTOR BINDING 14 1476 1.621e-07 0.0001506
2 NEUROPILIN BINDING 3 15 2.612e-06 0.001213
3 HEPARIN BINDING 5 157 9.952e-06 0.002311
4 SEMAPHORIN RECEPTOR BINDING 3 22 8.761e-06 0.002311
5 CHEMOREPELLENT ACTIVITY 3 27 1.653e-05 0.003072
6 GLYCOSAMINOGLYCAN BINDING 5 205 3.597e-05 0.005569
7 SULFUR COMPOUND BINDING 5 234 6.746e-05 0.008953
NumGOOverlapSizeP ValueAdj. P Value
1 EXTRACELLULAR SPACE 14 1376 6.774e-08 3.956e-05
2 PROTEINACEOUS EXTRACELLULAR MATRIX 8 356 2.292e-07 6.694e-05
3 EXTRACELLULAR MATRIX 8 426 8.912e-07 0.0001735
4 BASEMENT MEMBRANE 4 93 2.573e-05 0.003756
5 EXTRACELLULAR MATRIX COMPONENT 4 125 8.186e-05 0.009561

Over-represented Pathway

NumPathwayPathviewOverlapSizeP ValueAdj. P Value
1 PI3K_Akt_signaling_pathway_hsa04151 5 352 0.0004504 0.02243
2 Ras_signaling_pathway_hsa04014 4 232 0.0008628 0.02243
3 Autophagy_animal_hsa04140 3 128 0.001697 0.02942
4 Wnt_signaling_pathway_hsa04310 3 146 0.002469 0.0321
5 Cellular_senescence_hsa04218 3 160 0.003198 0.03326
6 Focal_adhesion_hsa04510 3 199 0.005879 0.03837
7 Mitophagy_animal_hsa04137 2 65 0.006437 0.03837
8 Rap1_signaling_pathway_hsa04015 3 206 0.006467 0.03837
9 Regulation_of_actin_cytoskeleton_hsa04810 3 208 0.006641 0.03837
10 MAPK_signaling_pathway_hsa04010 3 295 0.01705 0.08867
11 Sphingolipid_signaling_pathway_hsa04071 2 118 0.02009 0.09499
12 Apelin_signaling_pathway_hsa04371 2 137 0.02653 0.109
13 Signaling_pathways_regulating_pluripotency_of_stem_cells_hsa04550 2 139 0.02725 0.109
14 Cell_adhesion_molecules_.CAMs._hsa04514 2 145 0.02946 0.1094
15 Tight_junction_hsa04530 2 170 0.03939 0.1366
16 cAMP_signaling_pathway_hsa04024 2 198 0.05179 0.1683

lncRNA-mediated sponge

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Num lncRNA miRNAs           miRNAs count     Gene Sponge regulatory network lncRNA log2FC lncRNA pvalue Gene log2FC Gene pvalue lncRNA-gene Pearson correlation
1 RP11-815I9.4 hsa-miR-130a-3p;hsa-miR-148a-3p;hsa-miR-186-5p;hsa-miR-214-3p;hsa-miR-30a-5p;hsa-miR-30c-5p;hsa-miR-320a;hsa-miR-324-5p;hsa-miR-590-5p;hsa-miR-664a-3p 10 NRP1 Sponge network -0.348 0.02944 0.111 0.41779 0.39
2 OIP5-AS1 hsa-miR-130a-3p;hsa-miR-141-3p;hsa-miR-148a-3p;hsa-miR-186-5p;hsa-miR-214-3p;hsa-miR-30a-5p;hsa-miR-30b-5p;hsa-miR-30c-5p;hsa-miR-320a;hsa-miR-324-5p;hsa-miR-582-5p;hsa-miR-590-3p;hsa-miR-590-5p;hsa-miR-664a-3p 14 NRP1 Sponge network -0.421 0 0.111 0.41779 0.389
3 BHLHE40-AS1 hsa-miR-130a-3p;hsa-miR-139-5p;hsa-miR-148a-3p;hsa-miR-186-5p;hsa-miR-30a-5p;hsa-miR-30b-5p;hsa-miR-30c-5p;hsa-miR-30e-5p;hsa-miR-582-5p;hsa-miR-590-3p;hsa-miR-590-5p 11 NRP1 Sponge network -0.37 0.02438 0.111 0.41779 0.36
4 SNHG14 hsa-miR-130a-3p;hsa-miR-186-5p;hsa-miR-214-3p;hsa-miR-30b-5p;hsa-miR-30c-5p;hsa-miR-30e-5p;hsa-miR-320a;hsa-miR-324-5p;hsa-miR-361-5p;hsa-miR-590-3p;hsa-miR-590-5p;hsa-miR-664a-3p 12 NRP1 Sponge network -0.051 0.64448 0.111 0.41779 0.268

Quest ID: 3057e18407bf073f462a4bf3945928dd