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This regulatory network was inferred from the input dataset. The miRNAs and mRNAs are presented as round and rectangle nodes respectively. The numerical value popped up upon mouse over the gene node is the log2 transformed fold-change of the gene expression between the two groups. All of the nodes are clickable, and the detailed information of the miRNAs/mRNAs and related cancer pathway will be displayed in another window. The edges between nodes are supported by both interactions (predicted or experimentally verified) and correlations learnt from cancer dataset. The numerical value popped up upon mouse over the edge is the correlation beat value (effect size) between the two nodes. The experimental evidences of the edges reported in previous cancer studies are highlighted by red/orange color. All of these information can be accessed by the "mouse-over" action. This network shows a full map of the miRNA-mRNA regulation of the input gene list(s), and the hub miRNAs (with the high network degree/betweenness centrality) would be the potential cancer drivers or tumor suppressors. The full result table can be accessed in the "Regulations" tab.

"miRNACancerMAP" is also a network visualization tool for users to draw their regulatory network by personal customization. Users can set the complexity of the network by limiting the number of nodes or edges. And the color of the nodes can be defined by different categories of the mRNAs and miRNAs, such as Gene-Ontology, pathway, and expression status. Users can also select to use network degree or network betweenness centrality to define the node size. And edges can be black or colored by the correlation. Purple edge means negative correlation (mostly found between miRNA and mRNA), and blue edge means positive correlation (found in PPI or miRNA-miRNA sponge effect). We can also add the protein-protein interactions (PPI) into the network. This result will show the cluster of genes regulated by some specific miRNAs. Additionally, miRNA-miRNA edges can be added by the "miRNA sponge" button, presenting some clusters of miRNAs that have the interactions via sponge effect.

miRNA-gene regulations

(Download full result)

Num microRNA           Gene miRNA log2FC miRNA pvalue Gene log2FC Gene pvalue Interaction Correlation beta Correlation P-value PMID Reported in cancer studies
1 hsa-miR-140-5p ABCD3 -0.76 0 0.36 0.0002 miRanda -0.18 0 NA
2 hsa-miR-152-3p ABCD3 -0.27 0.00639 0.36 0.0002 MirTarget -0.15 1.0E-5 NA
3 hsa-miR-140-5p ABHD1 -0.76 0 -0.98 0 miRanda -0.13 0.01184 NA
4 hsa-miR-34a-5p ABHD2 0.13 0.13326 0.45 0.00053 mirMAP -0.12 0.01835 NA
5 hsa-miR-194-5p ACADSB 0.47 0 -0.52 0.002 mirMAP -0.23 0.00038 NA
6 hsa-miR-34a-5p ACSL4 0.13 0.13326 -1.48 0 miRNAWalker2 validate; MirTarget; miRNATAP -0.11 0.02677 NA
7 hsa-miR-34a-5p ADAM22 0.13 0.13326 -1.22 0 MirTarget; miRNATAP -0.33 5.0E-5 NA
8 hsa-miR-140-5p ADAMTS13 -0.76 0 0.49 0.00058 mirMAP -0.38 0 NA
9 hsa-miR-152-3p ADAMTS19 -0.27 0.00639 0.71 0.02881 MirTarget -0.36 0.00184 NA
10 hsa-miR-194-5p ADAMTS5 0.47 0 -3.55 0 mirMAP -0.42 0 NA
11 hsa-miR-140-5p ADCY1 -0.76 0 -0.05 0.84149 mirMAP -0.43 0 NA
12 hsa-miR-34a-5p ADCY1 0.13 0.13326 -0.05 0.84149 mirMAP -0.24 0.01304 NA
13 hsa-miR-140-5p ADCY6 -0.76 0 -0.63 0 MirTarget; PITA; miRanda; miRNATAP -0.16 0 NA
14 hsa-miR-34a-5p AFAP1L2 0.13 0.13326 -1.15 0 miRNAWalker2 validate -0.13 0.0145 NA
15 hsa-miR-194-5p AFF2 0.47 0 -1.78 0 mirMAP -0.18 0.01098 NA
16 hsa-miR-34a-5p AHNAK 0.13 0.13326 -1.77 0 miRNAWalker2 validate -0.15 0.00201 NA
17 hsa-miR-34a-5p AKAP13 0.13 0.13326 -0.61 0 mirMAP -0.11 0.0002 NA
18 hsa-miR-34a-5p AKAP6 0.13 0.13326 -2.28 0 MirTarget -0.13 0.0257 NA
19 hsa-miR-194-5p ALDH1L2 0.47 0 -0.04 0.78616 mirMAP -0.2 0.00037 NA
20 hsa-miR-140-5p ALOX15B -0.76 0 -0.75 0.01908 miRanda -0.25 0.0205 NA
21 hsa-miR-34a-5p ALX4 0.13 0.13326 -3.22 0 mirMAP -0.47 2.0E-5 NA
22 hsa-miR-140-5p AMACR -0.76 0 0.53 0 miRanda -0.15 0 NA
23 hsa-miR-194-5p ANGPTL1 0.47 0 -3.72 0 MirTarget -0.55 0 NA
24 hsa-miR-34a-5p ANK2 0.13 0.13326 -2.51 0 MirTarget; miRNATAP -0.32 0 NA
25 hsa-miR-34a-5p ANK3 0.13 0.13326 -0.03 0.84332 miRNATAP -0.14 0.00547 NA
26 hsa-miR-140-5p ANKRD42 -0.76 0 0.22 0.01213 MirTarget; miRanda -0.21 0 NA
27 hsa-miR-140-5p ANKRD52 -0.76 0 0.23 0.00024 PITA; miRanda; miRNATAP -0.12 0 NA
28 hsa-miR-34a-5p ANKS1A 0.13 0.13326 -0.37 0 MirTarget -0.1 2.0E-5 NA
29 hsa-miR-140-5p ANKS1B -0.76 0 0.2 0.2194 miRanda -0.32 0 NA
30 hsa-miR-140-5p AP1AR -0.76 0 0.37 0 miRanda -0.11 2.0E-5 NA
31 hsa-miR-140-5p AP2B1 -0.76 0 0.26 0.00183 PITA; miRanda -0.13 0 NA
32 hsa-miR-140-5p ARFIP2 -0.76 0 0.83 0 PITA; miRanda -0.3 0 NA
33 hsa-miR-34a-5p ARHGAP19 0.13 0.13326 -0.97 0 mirMAP -0.11 0.00019 NA
34 hsa-miR-194-5p ARHGAP24 0.47 0 -1.41 0 miRNATAP -0.23 0 NA
35 hsa-miR-140-5p ARHGAP32 -0.76 0 0.43 9.0E-5 miRanda -0.19 0 NA
36 hsa-miR-194-5p ARHGAP5 0.47 0 -0.91 0 miRNATAP -0.18 0 NA
37 hsa-miR-140-5p ARHGEF18 -0.76 0 0.6 0 miRanda -0.11 0 NA
38 hsa-miR-34a-5p ARHGEF33 0.13 0.13326 -0.66 0 MirTarget -0.1 0.03642 NA
39 hsa-miR-194-5p ARID4A 0.47 0 -0.86 0 miRNATAP -0.14 1.0E-5 NA
40 hsa-miR-140-5p ARMC9 -0.76 0 1.05 0 miRanda -0.26 0 NA
41 hsa-miR-140-5p ARV1 -0.76 0 0.72 0 miRanda -0.13 0 NA
42 hsa-miR-34a-5p ASTN1 0.13 0.13326 -2.96 0 MirTarget -0.54 0 NA
43 hsa-miR-34a-5p ASXL2 0.13 0.13326 -0.86 0 MirTarget -0.17 0.00682 NA
44 hsa-miR-140-5p ATG4B -0.76 0 0.43 0 miRanda -0.11 0 NA
45 hsa-miR-140-5p ATP6V1G1 -0.76 0 0.81 0 miRanda -0.17 0 NA
46 hsa-miR-194-5p ATP8B4 0.47 0 -1.46 0 MirTarget -0.25 0 NA
47 hsa-miR-140-5p B3GALT6 -0.76 0 0.69 0 miRanda -0.16 0 NA
48 hsa-miR-140-5p BBC3 -0.76 0 1.65 0 miRNATAP -0.47 0 NA
49 hsa-miR-140-5p BBS4 -0.76 0 0.09 0.27948 miRanda -0.15 0 NA
50 hsa-miR-34a-5p BCL2 0.13 0.13326 -0.9 0 miRNAWalker2 validate; miRTarBase -0.22 0.00143 24565525; 22623155; 21399894; 23155233; 24444609; 20687223; 24988056; 18803879; 19714243; 25053345; 20433755; 22964582; 23862748 In vitro and in vivo experiments showed that miR-34a and DOX can be efficiently encapsulated into HA-CS NPs and delivered into tumor cells or tumor tissues and enhance anti-tumor effects of DOX by suppressing the expression of non-pump resistance and anti-apoptosis proto-oncogene Bcl-2;MiR 34a inhibits proliferation and migration of breast cancer through down regulation of Bcl 2 and SIRT1; In this study we aimed to determine the effect of miR-34a on the growth of breast cancer and to investigate whether its effect is achieved by targeting Bcl-2 and SIRT1; Bcl-2 and SIRT1 as the targets of miR-34a were found to be in reverse correlation with ectopic expression of miR-34a;Quantitative PCR and western analysis confirmed decreased expression of two genes BCL-2 and CCND1 in docetaxel-resistant cells which are both targeted by miR-34a;The miR-34a expression levels in cells after irradiation at 30 and 60 Gy were 0.17- and 18.7-times the BCL2 and caspase-9 expression levels respectively;Functional analyses further indicate that restoration of miR-34a inhibits B cell lymphoma-2 Bcl-2 protein expression to withdraw the survival advantage of these resistant NSCLC cells;Thus in PC3PR cells reduced expression of miR-34a confers paclitaxel resistance via up-regulating SIRT1 and Bcl2 expression; MiR-34a and its downstream targets SIRT1 and Bcl2 play important roles in the development of paclitaxel resistance all of which can be useful biomarkers and promising therapeutic targets for the drug resistance in hormone-refractory prostate cancer;Target analysis indicated that micro RNA miR-34a directly regulates Bcl-2 and miR-34a overexpression decreased Bcl-2 protein level in gastric cancer cells; We also found that luteolin upregulates miR-34a expression and downregulates Bcl-2 expression; Based on these results we can draw the conclusion that luteolin partly decreases Bcl-2 expression through upregulating miR-34a expression;miR-34 targets Notch HMGA2 and Bcl-2 genes involved in the self-renewal and survival of cancer stem cells; Human gastric cancer cells were transfected with miR-34 mimics or infected with the lentiviral miR-34-MIF expression system and validated by miR-34 reporter assay using Bcl-2 3'UTR reporter; Human gastric cancer Kato III cells with miR-34 restoration reduced the expression of target genes Bcl-2 Notch and HMGA2; Bcl-2 3'UTR reporter assay showed that the transfected miR-34s were functional and confirmed that Bcl-2 is a direct target of miR-34; The mechanism of miR-34-mediated suppression of self-renewal appears to be related to the direct modulation of downstream targets Bcl-2 Notch and HMGA2 indicating that miR-34 may be involved in gastric cancer stem cell self-renewal/differentiation decision-making;Among the target proteins regulated by miR-34 are Notch pathway proteins and Bcl-2 suggesting the possibility of a role for miR-34 in the maintenance and survival of cancer stem cells; Our data support the view that miR-34 may be involved in pancreatic cancer stem cell self-renewal potentially via the direct modulation of downstream targets Bcl-2 and Notch implying that miR-34 may play an important role in pancreatic cancer stem cell self-renewal and/or cell fate determination;Manipulating miR-34a in prostate cancer cells confirms that this miRNA regulates BCL-2 and may in part regulate response to docetaxel;For instance miR-34a up-regulation corresponded with a down-regulation of BCL2 protein; Treating Par-4-overexpressing HT29 cells with a miR-34a antagomir functionally reversed both BCL2 down-regulation and apoptosis by 5-FU;Tumors harvested from these lungs have elevated levels of oncogenic miRNAs miR-21 and miR-155; are deficient for p53-regulated miRNAs; and have heightened expression of miR-34 target genes such as Met and Bcl-2;MicroRNA 34a targets Bcl 2 and sensitizes human hepatocellular carcinoma cells to sorafenib treatment; HCC tissues with lower miR-34a expression displayed higher expression of Bcl-2 protein than those with high expression of miR-34a; therefore an inverse correlation is evident between the miR-34a level and Bcl-2 expression; Bioinformatics and luciferase reporter assays revealed that miR-34a binds the 3'-UTR of the Bcl-2 mRNA and represses its translation; Western blotting analysis and qRT-PCR confirmed that Bcl-2 is inhibited by miR-34a overexpression; Functional analyses indicated that the restoration of miR-34a reduced cell viability promoted cell apoptosis and potentiated sorafenib-induced apoptosis and toxicity in HCC cell lines by inhibiting Bcl-2 expression
51 hsa-miR-140-5p BCL2L1 -0.76 0 0.52 0 PITA; miRanda; miRNATAP -0.18 0 NA
52 hsa-miR-140-5p BCL9 -0.76 0 1.09 0 MirTarget; PITA; miRanda; miRNATAP -0.21 0 NA
53 hsa-miR-140-5p BMP8A -0.76 0 2.55 0 miRanda -0.17 0.00068 NA
54 hsa-miR-194-5p BNC1 0.47 0 -2.84 0 MirTarget -0.43 5.0E-5 NA
55 hsa-miR-34a-5p BNC2 0.13 0.13326 -0.78 0 miRNATAP -0.13 0.03676 NA
56 hsa-miR-140-5p BRD8 -0.76 0 0.07 0.22169 miRanda -0.11 0 NA
57 hsa-miR-194-5p BRMS1L 0.47 0 -0.44 0 MirTarget -0.12 0 NA
58 hsa-miR-34a-5p BRPF3 0.13 0.13326 0.09 0.20587 MirTarget; miRNATAP -0.12 3.0E-5 NA
59 hsa-miR-140-5p BSN -0.76 0 -0.24 0.13233 mirMAP -0.15 0.0064 NA
60 hsa-miR-194-5p BTBD7 0.47 0 -0.65 0 miRNATAP -0.11 0.0001 NA
61 hsa-miR-34a-5p C17orf51 0.13 0.13326 -1.38 0 mirMAP -0.18 0.00028 NA
62 hsa-miR-34a-5p C1orf21 0.13 0.13326 -0.47 0.00106 mirMAP -0.15 0.01067 NA
63 hsa-miR-152-3p CABP7 -0.27 0.00639 1.18 0 MirTarget -0.2 0.00095 NA
64 hsa-miR-34a-5p CACHD1 0.13 0.13326 -2.57 0 MirTarget -0.38 0 NA
65 hsa-miR-194-5p CADM1 0.47 0 -0.07 0.58588 miRNATAP -0.13 0.0115 NA
66 hsa-miR-140-5p CADPS -0.76 0 1.86 0 miRanda -0.29 2.0E-5 NA
67 hsa-miR-140-5p CAMK2N1 -0.76 0 0.27 0.07667 PITA; miRanda -0.29 0 NA
68 hsa-miR-140-5p CAPN1 -0.76 0 0.6 0 miRanda; miRNATAP -0.12 0 NA
69 hsa-miR-34a-5p CAPN6 0.13 0.13326 -3.62 0 miRNATAP -0.8 0 NA
70 hsa-miR-140-5p CARD10 -0.76 0 -0.48 6.0E-5 miRanda -0.13 0.00133 NA
71 hsa-miR-140-5p CASC1 -0.76 0 0.07 0.72877 miRanda -0.54 0 NA
72 hsa-miR-140-5p CASD1 -0.76 0 -0.07 0.57131 miRNAWalker2 validate -0.1 0.00691 NA
73 hsa-miR-140-5p CBWD3 -0.76 0 0.89 0 miRanda -0.2 0 NA
74 hsa-miR-140-5p CC2D1A -0.76 0 0.42 0 miRanda -0.16 0 NA
75 hsa-miR-140-5p CCDC120 -0.76 0 0.74 0 miRanda -0.15 0 NA
76 hsa-miR-140-5p CCDC13 -0.76 0 -0.04 0.76305 miRanda -0.12 0.00611 NA
77 hsa-miR-140-5p CCDC30 -0.76 0 0.19 0.10313 miRanda -0.29 0 NA
78 hsa-miR-34a-5p CCDC50 0.13 0.13326 -1.33 0 miRNATAP -0.11 0.00025 NA
79 hsa-miR-140-5p CCDC78 -0.76 0 3.58 0 miRanda -0.82 0 NA
80 hsa-miR-140-5p CCNB1 -0.76 0 2.42 0 miRanda -0.15 0.00114 NA
81 hsa-miR-140-5p CCNF -0.76 0 1.72 0 miRanda -0.21 0 NA
82 hsa-miR-140-5p CD276 -0.76 0 0.96 0 miRanda -0.1 1.0E-5 NA
83 hsa-miR-194-5p CD302 0.47 0 -1.77 0 mirMAP -0.21 0 NA
84 hsa-miR-140-5p CD46 -0.76 0 0.22 0.00794 miRanda -0.14 0 NA
85 hsa-miR-194-5p CDC42BPA 0.47 0 -0.67 0 mirMAP -0.1 0.01633 NA
86 hsa-miR-140-5p CDHR3 -0.76 0 -0.46 0.04587 miRanda -0.2 0.01135 NA
87 hsa-miR-140-5p CDK1 -0.76 0 3.03 0 miRanda -0.14 0.01652 NA
88 hsa-miR-194-5p CDK14 0.47 0 -0.43 5.0E-5 MirTarget -0.17 6.0E-5 NA
89 hsa-miR-34a-5p CDKN1C 0.13 0.13326 -2.11 0 miRNATAP -0.28 0 NA
90 hsa-miR-140-5p CDKN3 -0.76 0 3.05 0 miRanda -0.14 0.01639 NA
91 hsa-miR-34a-5p CDON 0.13 0.13326 -0.99 0 miRNAWalker2 validate -0.13 0.01996 NA
92 hsa-miR-140-5p CEACAM6 -0.76 0 3.15 0 miRanda -0.72 0 NA
93 hsa-miR-34a-5p CELF2 0.13 0.13326 -2.12 0 miRNATAP -0.14 0.01317 NA
94 hsa-miR-140-5p CELF3 -0.76 0 2.06 0 miRanda -0.55 0 NA
95 hsa-miR-152-3p CELSR1 -0.27 0.00639 1.62 0 MirTarget -0.24 0.0001 NA
96 hsa-miR-152-3p CEP55 -0.27 0.00639 3.48 0 MirTarget -0.15 0.0288 NA
97 hsa-miR-140-5p CERCAM -0.76 0 1.06 0 miRanda; miRNATAP -0.25 0 NA
98 hsa-miR-194-5p CHD9 0.47 0 -1.21 0 miRNATAP -0.21 0 NA
99 hsa-miR-140-5p CHST15 -0.76 0 0.52 0 miRanda -0.23 0 NA
100 hsa-miR-194-5p CLDN19 0.47 0 -4.73 0 mirMAP -0.59 2.0E-5 NA
101 hsa-miR-140-5p CLEC5A -0.76 0 2.97 0 miRanda -0.14 0.03363 NA
102 hsa-miR-194-5p CLIP4 0.47 0 -2.32 0 MirTarget -0.21 0.00162 NA
103 hsa-miR-34a-5p CLOCK 0.13 0.13326 -0.44 0.00109 MirTarget -0.11 0.04508 NA
104 hsa-miR-34a-5p CNTN2 0.13 0.13326 -1.15 0 MirTarget; miRNATAP -0.27 0.00433 NA
105 hsa-miR-152-3p COL2A1 -0.27 0.00639 -0.25 0.56528 MirTarget -0.3 0.04906 NA
106 hsa-miR-140-5p COPG2 -0.76 0 0.25 0.00034 miRanda -0.13 0 NA
107 hsa-miR-140-5p COQ4 -0.76 0 0.53 0 miRanda -0.25 0 NA
108 hsa-miR-140-5p CORIN -0.76 0 2 0 miRanda -0.34 0 NA
109 hsa-miR-140-5p CORO2A -0.76 0 1.38 0 MirTarget; miRanda; miRNATAP -0.29 0 NA
110 hsa-miR-34a-5p CR2 0.13 0.13326 -0.58 0.1206 MirTarget -0.33 0.0271 NA
111 hsa-miR-140-5p CREB3L1 -0.76 0 1.98 0 MirTarget; miRanda; miRNATAP -0.45 0 NA
112 hsa-miR-140-5p CREB3L4 -0.76 0 1.73 0 miRanda -0.57 0 NA
113 hsa-miR-140-5p CROT -0.76 0 0.04 0.77707 miRNATAP -0.28 0 NA
114 hsa-miR-34a-5p CRY2 0.13 0.13326 -1.2 0 MirTarget -0.13 7.0E-5 NA
115 hsa-miR-140-5p CST9L -0.76 0 0.9 0.00141 miRanda -0.54 0 NA
116 hsa-miR-34a-5p CTDSP2 0.13 0.13326 -0.73 0 miRNATAP -0.14 0 NA
117 hsa-miR-194-5p CTDSPL 0.47 0 -0.59 0 mirMAP -0.14 0 NA
118 hsa-miR-140-5p CTSF -0.76 0 -0.45 5.0E-5 miRanda -0.15 4.0E-5 NA
119 hsa-miR-194-5p CTTNBP2NL 0.47 0 -0.5 0 MirTarget -0.11 9.0E-5 NA
120 hsa-miR-140-5p CUEDC1 -0.76 0 0.54 0 PITA; miRanda -0.19 0 NA
121 hsa-miR-140-5p CXXC4 -0.76 0 -0.35 0.08009 miRanda -0.13 0.04681 NA
122 hsa-miR-140-5p CYB5D1 -0.76 0 -0.14 0.07571 miRanda -0.15 0 NA
123 hsa-miR-194-5p CYP26B1 0.47 0 -2.18 0 mirMAP -0.17 0.01637 NA
124 hsa-miR-140-5p CYTH2 -0.76 0 0.7 0 MirTarget; miRanda; miRNATAP -0.27 0 NA
125 hsa-miR-194-5p CYTH3 0.47 0 -0.74 0 mirMAP -0.15 3.0E-5 NA
126 hsa-miR-194-5p DAAM1 0.47 0 -0.83 0 miRNATAP -0.19 4.0E-5 NA
127 hsa-miR-34a-5p DAPK2 0.13 0.13326 -1.03 0 MirTarget -0.1 0.02207 27704360 E2F 1 promotes DAPK2 induced anti tumor immunity of gastric cancer cells by targeting miR 34a
128 hsa-miR-194-5p DCBLD2 0.47 0 -0.92 0 MirTarget -0.2 0 NA
129 hsa-miR-140-5p DCDC1 -0.76 0 0.96 5.0E-5 PITA; miRanda -0.52 0 NA
130 hsa-miR-140-5p DCDC2 -0.76 0 -1.86 0 miRanda -0.2 0.0478 NA
131 hsa-miR-34a-5p DCX 0.13 0.13326 -2.75 0 MirTarget; miRNATAP -0.68 0 NA
132 hsa-miR-140-5p DHCR24 -0.76 0 0.77 0 miRanda -0.32 0 NA
133 hsa-miR-140-5p DHRS4L1 -0.76 0 -0.1 0.44303 miRanda -0.21 0 NA
134 hsa-miR-194-5p DISC1 0.47 0 -0.75 0 MirTarget -0.13 0.00032 NA
135 hsa-miR-34a-5p DLL1 0.13 0.13326 -0.95 0 miRNAWalker2 validate; miRTarBase; miRNATAP -0.18 0.0003 22438124 Delta tocotrienol suppresses Notch 1 pathway by upregulating miR 34a in nonsmall cell lung cancer cells
136 hsa-miR-194-5p DMD 0.47 0 -3.78 0 MirTarget; miRNATAP -0.37 1.0E-5 NA
137 hsa-miR-152-3p DMPK -0.27 0.00639 0.32 0.00202 MirTarget -0.16 1.0E-5 NA
138 hsa-miR-140-5p DNAH14 -0.76 0 1.8 0 miRanda -0.21 0 NA
139 hsa-miR-140-5p DNAH7 -0.76 0 -0.38 0.0511 miRanda -0.32 0 NA
140 hsa-miR-140-5p DNAJA4 -0.76 0 0.78 0 miRanda -0.22 0 NA
141 hsa-miR-140-5p DNMBP -0.76 0 -0.67 0 miRanda -0.1 0.01111 NA
142 hsa-miR-152-3p DNMT1 -0.27 0.00639 1.04 0 miRNAWalker2 validate; miRTarBase; MirTarget -0.16 0 27475839; 21868754; 25004396; 20578129; 24998573; 23318422 mRNA and protein expression profile of DNMT1 implicate that miR-152 targets DNMT1 mRNA and inhibits its protein expression; Further experiments revealed that DNMT1 plays crucial role for regulation of miR-152 gene; When DNMT1 protein function is blocked miR-152 expression prevails and destroys the mRNA of DNMT1; this molecular regulatory mechanism is creating a cyclic feedback loop which is now focused as DNMT1/miR-152 switch for on/off of DNMT1 target genes; We have demonstrated further that DNMT1 down regulation mediated upregulation of CDH1 hereafter DNMT1/CDH1 loop in presence of ectopic-excess of miR-152 prevents migration of cancer cells;Epigenetic silencing documented in miR-152 was consistent with its location at 17q21.32 in intron 1 of the COPZ2 gene which is also silenced often in endometrial cancer by DNA hypermethylation and also with evidence that miR-152 targets the DNA methyltransferase DNMT1;There appeared to be a reciprocal regulatory relationship of miR-152/DNMT1 expression as cells treated with siRNA DNMT1 caused miR-152 to be re-expressed in all cell lines;Our results showed that the expression of microRNA-152 miR-152 was frequently down-regulated in HBV-related HCC tissues in comparison with adjacent noncancerous hepatic tissues and was inversely correlated to DNA methyltransferase 1 DNMT1 messenger RNA mRNA expression in HBV-related HCCs; The forced expression of miR-152 in liver cell lines resulted in a marked reduction of the expression of DNMT1 at both the mRNA and protein levels by directly targeting the 3' untranslated regions of DNMT1; Our findings suggest that miR-152 is frequently down-regulated and regulates DNMT1 in HBV-related HCC;Furthermore Western blotting showed that the miR-152 mimic downregulated Wnt-1 DNMT1 ERK1/2 AKT and TNFRS6B signaling;MiR 152 and miR 185 co contribute to ovarian cancer cells cisplatin sensitivity by targeting DNMT1 directly: a novel epigenetic therapy independent of decitabine; The overexpression of miR-152 or miR-185 increased cisplatin sensitivity of SKOV3/DDP and A2780/DDP cells by inhibiting proliferation and promoting apoptosis then we further confirmed that these miRNAs functioned through suppressing DNA methyltransferase 1 DNMT1 directly; Our results indicated that miR-152 and miR-185 were involved in ovarian cancer cisplatin resistance in vitro and in vivo by targeting DNMT1 directly
143 hsa-miR-140-5p DNPEP -0.76 0 0.47 0 miRNAWalker2 validate; miRTarBase -0.16 0 NA
144 hsa-miR-140-5p DPP9 -0.76 0 0.84 0 miRanda -0.19 0 NA
145 hsa-miR-140-5p DUSP16 -0.76 0 -0 0.97223 miRNATAP -0.17 0 NA
146 hsa-miR-140-5p EARS2 -0.76 0 0.69 0 miRanda -0.2 0 NA
147 hsa-miR-140-5p ECHDC2 -0.76 0 -0.58 0 miRanda -0.16 1.0E-5 NA
148 hsa-miR-140-5p ECM1 -0.76 0 1.1 0 miRanda -0.31 0 NA
149 hsa-miR-34a-5p EDAR 0.13 0.13326 -2.79 0 miRNATAP -0.46 4.0E-5 NA
150 hsa-miR-194-5p EDN1 0.47 0 -1.72 0 MirTarget; miRNATAP -0.22 0.00072 NA

Over-represented Gene Ontology Biological Process

NumGOOverlapSizeP ValueAdj. P Value
1 INTRACELLULAR SIGNAL TRANSDUCTION 99 1572 4.328e-11 1.007e-07
2 NEUROGENESIS 92 1402 2.666e-11 1.007e-07
3 REGULATION OF INTRACELLULAR SIGNAL TRANSDUCTION 99 1656 7.571e-10 1.174e-06
4 REGULATION OF MULTICELLULAR ORGANISMAL DEVELOPMENT 99 1672 1.264e-09 1.47e-06
5 REGULATION OF CELL DIFFERENTIATION 90 1492 3.289e-09 3.061e-06
6 POSITIVE REGULATION OF CELL COMMUNICATION 89 1532 2.422e-08 1.878e-05
7 ORGAN MORPHOGENESIS 58 841 3.152e-08 1.883e-05
8 TISSUE DEVELOPMENT 88 1518 3.237e-08 1.883e-05
9 NEURON DIFFERENTIATION 59 874 5.057e-08 2.615e-05
10 REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 98 1784 6.789e-08 3.159e-05
11 REGULATION OF MUSCLE CELL DIFFERENTIATION 20 152 8.564e-08 3.623e-05
12 POSITIVE REGULATION OF MULTICELLULAR ORGANISMAL PROCESS 81 1395 1.148e-07 4.451e-05
13 POSITIVE REGULATION OF DEVELOPMENTAL GROWTH 20 156 1.324e-07 4.738e-05
14 CELL DEVELOPMENT 82 1426 1.431e-07 4.756e-05
15 REGULATION OF MEMBRANE POTENTIAL 31 343 2.165e-07 5.545e-05
16 REGULATION OF NEURON DIFFERENTIATION 42 554 2.264e-07 5.545e-05
17 CELL MORPHOGENESIS INVOLVED IN DIFFERENTIATION 40 513 2.129e-07 5.545e-05
18 REGULATION OF ANATOMICAL STRUCTURE MORPHOGENESIS 64 1021 2.01e-07 5.545e-05
19 REGULATION OF TRANSPORT 97 1804 2.194e-07 5.545e-05
20 POSITIVE REGULATION OF DEVELOPMENTAL PROCESS 69 1142 2.584e-07 6.011e-05
21 CELL MORPHOGENESIS INVOLVED IN NEURON DIFFERENTIATION 32 368 3.305e-07 7.134e-05
22 REGULATION OF CELL DEVELOPMENT 55 836 3.373e-07 7.134e-05
23 REGULATION OF GROWTH 45 633 5.121e-07 0.0001036
24 CELLULAR COMPONENT MORPHOGENESIS 57 900 7.008e-07 0.0001359
25 SENSORY ORGAN MORPHOGENESIS 24 239 7.858e-07 0.0001462
26 POSITIVE REGULATION OF GENE EXPRESSION 92 1733 8.267e-07 0.0001479
27 CEREBRAL CORTEX DEVELOPMENT 15 105 1.219e-06 0.0002021
28 NEGATIVE REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 49 740 1.26e-06 0.0002021
29 CENTRAL NERVOUS SYSTEM DEVELOPMENT 55 872 1.258e-06 0.0002021
30 REGULATION OF CELL PROLIFERATION 81 1496 1.928e-06 0.000299
31 REGULATION OF DEVELOPMENTAL GROWTH 26 289 2.233e-06 0.0003234
32 POSITIVE REGULATION OF MUSCLE CELL DIFFERENTIATION 13 84 2.493e-06 0.0003234
33 POSITIVE REGULATION OF BIOSYNTHETIC PROCESS 93 1805 2.561e-06 0.0003234
34 NEURON PROJECTION MORPHOGENESIS 32 402 2.273e-06 0.0003234
35 POSITIVE REGULATION OF GROWTH 23 238 2.572e-06 0.0003234
36 POSITIVE REGULATION OF TRANSPORT 57 936 2.393e-06 0.0003234
37 POSITIVE REGULATION OF CELL DIFFERENTIATION 52 823 2.36e-06 0.0003234
38 CELL PART MORPHOGENESIS 43 633 3e-06 0.0003673
39 REGULATION OF CELLULAR LOCALIZATION 71 1277 3.557e-06 0.0004244
40 PHOSPHATE CONTAINING COMPOUND METABOLIC PROCESS 99 1977 4.005e-06 0.0004545
41 SENSORY ORGAN DEVELOPMENT 36 493 3.936e-06 0.0004545
42 REGULATION OF NERVOUS SYSTEM DEVELOPMENT 48 750 4.131e-06 0.0004576
43 NEURON DEVELOPMENT 45 687 4.581e-06 0.0004634
44 FOREBRAIN DEVELOPMENT 29 357 4.557e-06 0.0004634
45 EAR DEVELOPMENT 20 195 4.68e-06 0.0004634
46 HEAD DEVELOPMENT 46 709 4.608e-06 0.0004634
47 TELENCEPHALON DEVELOPMENT 22 228 4.337e-06 0.0004634
48 RENAL TUBULE DEVELOPMENT 12 78 6.451e-06 0.0006253
49 PALLIUM DEVELOPMENT 17 153 8.293e-06 0.0007875
50 REGULATION OF CELLULAR COMPONENT MOVEMENT 48 771 8.637e-06 0.0008038
51 GROWTH 31 410 9.261e-06 0.0008449
52 REGULATION OF HISTONE H3 K9 METHYLATION 6 17 9.516e-06 0.0008515
53 POSITIVE REGULATION OF MUSCLE TISSUE DEVELOPMENT 10 56 9.762e-06 0.0008571
54 MUSCLE ORGAN DEVELOPMENT 24 277 1.032e-05 0.0008891
55 ENZYME LINKED RECEPTOR PROTEIN SIGNALING PATHWAY 44 689 1.105e-05 0.0009079
56 NEURON MIGRATION 14 110 1.09e-05 0.0009079
57 RESPONSE TO GROWTH FACTOR 34 475 1.112e-05 0.0009079
58 EMBRYONIC ORGAN MORPHOGENESIS 24 279 1.164e-05 0.0009339
59 MOVEMENT OF CELL OR SUBCELLULAR COMPONENT 69 1275 1.212e-05 0.0009562
60 NEURON PROJECTION DEVELOPMENT 37 545 1.495e-05 0.00116
61 POSITIVE REGULATION OF HEART GROWTH 7 27 1.672e-05 0.001275
62 REGULATION OF MUSCLE HYPERTROPHY 8 37 1.767e-05 0.001326
63 POSITIVE REGULATION OF NEURON DIFFERENTIATION 25 306 1.862e-05 0.001354
64 HEART DEVELOPMENT 33 466 1.858e-05 0.001354
65 PROTEIN LOCALIZATION 89 1805 2.38e-05 0.001678
66 PHOSPHORYLATION 66 1228 2.354e-05 0.001678
67 MUSCLE STRUCTURE DEVELOPMENT 31 432 2.573e-05 0.001787
68 IMMUNE SYSTEM DEVELOPMENT 38 582 2.723e-05 0.001841
69 EMBRYONIC MORPHOGENESIS 36 539 2.753e-05 0.001841
70 POSITIVE REGULATION OF INTRACELLULAR SIGNAL TRANSDUCTION 51 876 2.769e-05 0.001841
71 LOCOMOTION 61 1114 2.839e-05 0.00186
72 NEGATIVE REGULATION OF CELL DIFFERENTIATION 39 609 3.285e-05 0.002123
73 REGULATION OF SECRETION 43 699 3.384e-05 0.002128
74 NEURON PROJECTION GUIDANCE 19 205 3.38e-05 0.002128
75 POSITIVE REGULATION OF PROTEIN METABOLIC PROCESS 76 1492 3.457e-05 0.002144
76 MODULATION OF EXCITATORY POSTSYNAPTIC POTENTIAL 7 30 3.526e-05 0.002159
77 POSITIVE REGULATION OF RESPONSE TO STIMULUS 93 1929 3.612e-05 0.002183
78 POSITIVE REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 56 1004 3.703e-05 0.002209
79 ANATOMICAL STRUCTURE FORMATION INVOLVED IN MORPHOGENESIS 54 957 3.758e-05 0.002213
80 MORPHOGENESIS OF AN EPITHELIUM 29 400 3.871e-05 0.002251
81 NEPHRON EPITHELIUM DEVELOPMENT 12 93 4.003e-05 0.002299
82 NEGATIVE REGULATION OF NEURON DIFFERENTIATION 18 191 4.338e-05 0.002462
83 ACTION POTENTIAL 12 94 4.457e-05 0.002499
84 EMBRYO DEVELOPMENT 51 894 4.691e-05 0.002598
85 TISSUE MORPHOGENESIS 35 533 5.015e-05 0.002745
86 CELL FATE DETERMINATION 8 43 5.606e-05 0.003033
87 CELL PROJECTION ORGANIZATION 51 902 5.887e-05 0.003149
88 REGULATION OF PROTEIN LOCALIZATION 53 950 5.975e-05 0.003159
89 REGULATION OF NEURON DEATH 21 252 6.415e-05 0.003298
90 CARDIOVASCULAR SYSTEM DEVELOPMENT 46 788 6.451e-05 0.003298
91 CIRCULATORY SYSTEM DEVELOPMENT 46 788 6.451e-05 0.003298
92 NEURON RECOGNITION 7 33 6.809e-05 0.003443
93 RESPONSE TO ENDOGENOUS STIMULUS 73 1450 7.243e-05 0.003624
94 DEVELOPMENTAL GROWTH 25 333 7.491e-05 0.003708
95 CELLULAR RESPONSE TO ENDOGENOUS STIMULUS 55 1008 7.812e-05 0.00382
96 NEPHRON DEVELOPMENT 13 115 7.88e-05 0.00382
97 REGULATION OF STRIATED MUSCLE CELL DIFFERENTIATION 11 85 8.112e-05 0.003891
98 PIGMENTATION 11 86 9.038e-05 0.004227
99 POSITIVE REGULATION OF PROTEIN MODIFICATION PROCESS 60 1135 8.922e-05 0.004227
100 CAMERA TYPE EYE MORPHOGENESIS 12 101 9.084e-05 0.004227
101 PROTEIN PHOSPHORYLATION 52 944 9.68e-05 0.00446
102 CELL CELL JUNCTION ASSEMBLY 10 74 0.0001176 0.005329
103 EYE MORPHOGENESIS 14 136 0.000118 0.005329
104 NEGATIVE REGULATION OF CELL DEVELOPMENT 23 303 0.0001219 0.005451
105 REGULATION OF CELL PROJECTION ORGANIZATION 35 558 0.0001242 0.005451
106 EMBRYONIC ORGAN DEVELOPMENT 28 406 0.0001236 0.005451
107 REGULATION OF NEURON PROJECTION DEVELOPMENT 28 408 0.0001343 0.005679
108 CELL FATE COMMITMENT 19 227 0.0001333 0.005679
109 REGULATION OF PROTEIN MODIFICATION PROCESS 82 1710 0.0001316 0.005679
110 POSITIVE REGULATION OF CELL DEVELOPMENT 31 472 0.000133 0.005679
111 REGULATION OF PHOSPHATIDYLINOSITOL 3 KINASE SIGNALING 14 138 0.0001379 0.005759
112 POSITIVE REGULATION OF MOLECULAR FUNCTION 85 1791 0.0001389 0.005759
113 EYE DEVELOPMENT 24 326 0.0001399 0.005759
114 ANATOMICAL STRUCTURE ARRANGEMENT 5 17 0.0001473 0.006014
115 POSITIVE REGULATION OF PHOSPHATE METABOLIC PROCESS 55 1036 0.0001584 0.006261
116 POSITIVE REGULATION OF PHOSPHORUS METABOLIC PROCESS 55 1036 0.0001584 0.006261
117 TRANSMEMBRANE RECEPTOR PROTEIN TYROSINE KINASE SIGNALING PATHWAY 32 498 0.0001554 0.006261
118 POSITIVE REGULATION OF SECRETION 26 370 0.0001588 0.006261
119 REGULATION OF MUSCLE ADAPTATION 9 63 0.0001663 0.006501
120 POSITIVE REGULATION OF ORGAN GROWTH 7 38 0.0001751 0.00679
121 NEGATIVE REGULATION OF CELL DEATH 48 872 0.0001825 0.006961
122 REGULATION OF MUSCLE SYSTEM PROCESS 17 195 0.0001822 0.006961
123 KIDNEY EPITHELIUM DEVELOPMENT 13 125 0.0001847 0.006987
124 NEGATIVE REGULATION OF CELL COMMUNICATION 61 1192 0.0001893 0.007104
125 DENDRITE DEVELOPMENT 10 79 0.0002044 0.00761
126 REGULATION OF SYSTEM PROCESS 32 507 0.0002145 0.00792
127 MUSCLE TISSUE DEVELOPMENT 21 275 0.0002185 0.008005
128 POSITIVE REGULATION OF STRIATED MUSCLE CELL DIFFERENTIATION 8 52 0.000226 0.008215
129 FOREBRAIN GENERATION OF NEURONS 9 66 0.0002389 0.008615
130 REGULATION OF SMALL GTPASE MEDIATED SIGNAL TRANSDUCTION 21 278 0.0002533 0.009064
131 POSITIVE REGULATION OF CELL PROLIFERATION 45 814 0.0002635 0.009084
132 POSITIVE REGULATION OF CARDIAC MUSCLE TISSUE DEVELOPMENT 6 29 0.0002634 0.009084
133 NEURONAL STEM CELL POPULATION MAINTENANCE 5 19 0.0002626 0.009084
134 SKELETAL MUSCLE CELL DIFFERENTIATION 8 53 0.0002588 0.009084
135 CEREBRAL CORTEX RADIALLY ORIENTED CELL MIGRATION 6 29 0.0002634 0.009084
136 REGULATION OF GTPASE ACTIVITY 39 673 0.0002673 0.009147
137 POSITIVE REGULATION OF ESTABLISHMENT OF PROTEIN LOCALIZATION 32 514 0.0002735 0.00929
138 SINGLE ORGANISM BEHAVIOR 26 384 0.0002841 0.009498
139 PEPTIDYL SERINE MODIFICATION 14 148 0.0002878 0.009498
140 PEPTIDYL AMINO ACID MODIFICATION 46 841 0.0002856 0.009498
141 POSITIVE REGULATION OF CATALYTIC ACTIVITY 73 1518 0.0002907 0.009498
142 CENTRAL NERVOUS SYSTEM NEURON DIFFERENTIATION 15 166 0.0002919 0.009498
143 MODULATION OF SYNAPTIC TRANSMISSION 22 301 0.0002893 0.009498
144 NEGATIVE REGULATION OF NERVOUS SYSTEM DEVELOPMENT 20 262 0.0003075 0.009916
145 TUBE MORPHOGENESIS 23 323 0.000309 0.009916
NumGOOverlapSizeP ValueAdj. P Value
1 ENZYME BINDING 100 1737 4.524e-09 4.203e-06
2 TRANSCRIPTION FACTOR ACTIVITY RNA POLYMERASE II CORE PROMOTER PROXIMAL REGION SEQUENCE SPECIFIC BINDING 30 328 2.627e-07 0.000122
3 REGULATORY REGION NUCLEIC ACID BINDING 52 818 1.976e-06 0.0005926
4 RNA POLYMERASE II TRANSCRIPTION FACTOR ACTIVITY SEQUENCE SPECIFIC DNA BINDING 43 629 2.551e-06 0.0005926
5 KINASE ACTIVITY 52 842 4.541e-06 0.0008436
6 NUCLEIC ACID BINDING TRANSCRIPTION FACTOR ACTIVITY 65 1199 2.09e-05 0.003236
7 TRANSMEMBRANE RECEPTOR PROTEIN KINASE ACTIVITY 11 81 5.173e-05 0.004375
8 PROTEIN COMPLEX SCAFFOLD 10 68 5.651e-05 0.004375
9 TRANSMEMBRANE RECEPTOR PROTEIN TYROSINE KINASE ACTIVITY 10 64 3.301e-05 0.004375
10 TRANSCRIPTIONAL ACTIVATOR ACTIVITY RNA POLYMERASE II CORE PROMOTER PROXIMAL REGION SEQUENCE SPECIFIC BINDING 20 226 4.111e-05 0.004375
11 PROTEIN DOMAIN SPECIFIC BINDING 39 624 5.576e-05 0.004375
12 TRANSFERASE ACTIVITY TRANSFERRING PHOSPHORUS CONTAINING GROUPS 55 992 5.112e-05 0.004375
13 DOUBLE STRANDED DNA BINDING 45 764 6.286e-05 0.004492
14 TRANSCRIPTIONAL ACTIVATOR ACTIVITY RNA POLYMERASE II TRANSCRIPTION REGULATORY REGION SEQUENCE SPECIFIC BINDING 24 315 8.254e-05 0.005477
15 PROTEIN KINASE ACTIVITY 39 640 9.549e-05 0.005914
16 SEQUENCE SPECIFIC DNA BINDING 55 1037 0.0001623 0.009425
NumGOOverlapSizeP ValueAdj. P Value
1 CELL JUNCTION 76 1151 1.344e-09 7.849e-07
2 PLASMA MEMBRANE REGION 61 929 7.948e-08 2.321e-05
3 CELL CELL JUNCTION 32 383 8.001e-07 0.0001265
4 MEMBRANE REGION 67 1134 8.666e-07 0.0001265
5 NEURON PROJECTION 56 942 6.039e-06 0.0005878
6 CELL PROJECTION 91 1786 5.249e-06 0.0005878
7 NEURON PART 69 1265 9.358e-06 0.0007589
8 SYNAPSE 47 754 1.04e-05 0.0007589
9 APICAL PART OF CELL 28 361 1.566e-05 0.001016
10 APICAL PLASMA MEMBRANE 24 292 2.469e-05 0.001442
11 CYTOPLASMIC REGION 23 287 5.365e-05 0.002848
12 APICAL JUNCTION COMPLEX 14 128 6.096e-05 0.002967
13 CELL CORTEX 20 238 8.478e-05 0.003809
14 CELL CORTEX PART 13 119 0.0001121 0.004678
15 SOMATODENDRITIC COMPARTMENT 39 650 0.0001319 0.005135
16 BASOLATERAL PLASMA MEMBRANE 18 211 0.0001565 0.005711

Over-represented Pathway

NumPathwayPathviewOverlapSizeP ValueAdj. P Value
1 Wnt_signaling_pathway_hsa04310 12 146 0.002567 0.03441
2 Rap1_signaling_pathway_hsa04015 15 206 0.002643 0.03441
3 MAPK_signaling_pathway_hsa04010 19 295 0.003137 0.03441
4 Hedgehog_signaling_pathway_hsa04340 6 47 0.003662 0.03441
5 Apoptosis_multiple_species_hsa04215 5 33 0.003706 0.03441
6 Hippo_signaling_pathway_hsa04390 12 154 0.00397 0.03441
7 Cellular_senescence_hsa04218 12 160 0.005382 0.03998
8 Gap_junction_hsa04540 8 88 0.007098 0.04614
9 PI3K_Akt_signaling_pathway_hsa04151 20 352 0.00971 0.0561
10 Hippo_signaling_pathway_multiple_species_hsa04392 4 29 0.013 0.0676
11 Ras_signaling_pathway_hsa04014 14 232 0.01742 0.08213
12 Phospholipase_D_signaling_pathway_hsa04072 10 146 0.01895 0.08213
13 Focal_adhesion_hsa04510 12 199 0.02656 0.1062
14 Apoptosis_hsa04210 9 138 0.03319 0.1195
15 Signaling_pathways_regulating_pluripotency_of_stem_cells_hsa04550 9 139 0.03453 0.1195
16 cGMP_PKG_signaling_pathway_hsa04022 10 163 0.03678 0.1195
17 Phosphatidylinositol_signaling_system_hsa04070 7 99 0.03932 0.1203
18 Oocyte_meiosis_hsa04114 8 124 0.04552 0.1315
19 Peroxisome_hsa04146 6 83 0.04964 0.1359
20 p53_signaling_pathway_hsa04115 5 68 0.06609 0.1718
21 Apelin_signaling_pathway_hsa04371 8 137 0.07286 0.1804
22 Adherens_junction_hsa04520 5 72 0.08019 0.1893
23 NF_kappa_B_signaling_pathway_hsa04064 6 95 0.08373 0.1893
24 AMPK_signaling_pathway_hsa04152 7 121 0.09317 0.2019
25 HIF_1_signaling_pathway_hsa04066 6 100 0.101 0.21
26 mTOR_signaling_pathway_hsa04150 8 151 0.1114 0.2229
27 Autophagy_animal_hsa04140 7 128 0.1161 0.2237
28 Calcium_signaling_pathway_hsa04020 9 182 0.1298 0.2411
29 ErbB_signaling_pathway_hsa04012 5 85 0.1359 0.2436
30 Endocytosis_hsa04144 11 244 0.1597 0.2768
31 Tight_junction_hsa04530 8 170 0.1782 0.2968
32 Cell_adhesion_molecules_.CAMs._hsa04514 7 145 0.1826 0.2968
33 Notch_signaling_pathway_hsa04330 3 48 0.1975 0.3112
34 Jak_STAT_signaling_pathway_hsa04630 7 162 0.2614 0.3911
35 TNF_signaling_pathway_hsa04668 5 108 0.2633 0.3911
36 FoxO_signaling_pathway_hsa04068 5 132 0.4144 0.5985
37 cAMP_signaling_pathway_hsa04024 7 198 0.447 0.6282
38 ECM_receptor_interaction_hsa04512 3 82 0.4894 0.6697
39 TGF_beta_signaling_pathway_hsa04350 3 84 0.5055 0.674
40 Sphingolipid_signaling_pathway_hsa04071 4 118 0.5234 0.6804
41 Cell_cycle_hsa04110 4 124 0.5627 0.7013
42 VEGF_signaling_pathway_hsa04370 2 59 0.5665 0.7013
43 Necroptosis_hsa04217 5 164 0.6047 0.7308
44 Mitophagy_animal_hsa04137 2 65 0.6194 0.7308
45 Cytokine_cytokine_receptor_interaction_hsa04060 8 270 0.6353 0.7308
46 Lysosome_hsa04142 3 123 0.7571 0.8155
47 Regulation_of_actin_cytoskeleton_hsa04810 5 208 0.7981 0.8301
48 Neuroactive_ligand_receptor_interaction_hsa04080 6 278 0.8827 0.9
49 Phagosome_hsa04145 2 152 0.9573 0.9573

Quest ID: 347c14a12be866ff273644500e2f5b95