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This regulatory network was inferred from the input dataset. The miRNAs and mRNAs are presented as round and rectangle nodes respectively. The numerical value popped up upon mouse over the gene node is the log2 transformed fold-change of the gene expression between the two groups. All of the nodes are clickable, and the detailed information of the miRNAs/mRNAs and related cancer pathway will be displayed in another window. The edges between nodes are supported by both interactions (predicted or experimentally verified) and correlations learnt from cancer dataset. The numerical value popped up upon mouse over the edge is the correlation beat value (effect size) between the two nodes. The experimental evidences of the edges reported in previous cancer studies are highlighted by red/orange color. All of these information can be accessed by the "mouse-over" action. This network shows a full map of the miRNA-mRNA regulation of the input gene list(s), and the hub miRNAs (with the high network degree/betweenness centrality) would be the potential cancer drivers or tumor suppressors. The full result table can be accessed in the "Regulations" tab.

"miRNACancerMAP" is also a network visualization tool for users to draw their regulatory network by personal customization. Users can set the complexity of the network by limiting the number of nodes or edges. And the color of the nodes can be defined by different categories of the mRNAs and miRNAs, such as Gene-Ontology, pathway, and expression status. Users can also select to use network degree or network betweenness centrality to define the node size. And edges can be black or colored by the correlation. Purple edge means negative correlation (mostly found between miRNA and mRNA), and blue edge means positive correlation (found in PPI or miRNA-miRNA sponge effect). We can also add the protein-protein interactions (PPI) into the network. This result will show the cluster of genes regulated by some specific miRNAs. Additionally, miRNA-miRNA edges can be added by the "miRNA sponge" button, presenting some clusters of miRNAs that have the interactions via sponge effect.

miRNA-gene regulations

(Download full result)

Num microRNA           Gene miRNA log2FC miRNA pvalue Gene log2FC Gene pvalue Interaction Correlation beta Correlation P-value PMID Reported in cancer studies
1 hsa-miR-148a-3p A4GNT -0.43 0.74664 1.01 0.03605 MirTarget -0.73 0 NA
2 hsa-miR-455-3p AAK1 0.05 0.95193 0.06 0.86766 PITA -0.2 0 NA
3 hsa-miR-146b-5p AASS -0.14 0.85977 -0.82 0.08743 miRanda -0.17 0.01702 NA
4 hsa-miR-30e-5p ABL2 0.17 0.8725 0.06 0.85246 mirMAP -0.18 5.0E-5 NA
5 hsa-miR-30e-5p ABR 0.17 0.8725 0.17 0.58738 mirMAP -0.25 0.00305 NA
6 hsa-miR-455-3p ACAN 0.05 0.95193 0.61 0.09493 MirTarget; miRNATAP -0.82 0 NA
7 hsa-miR-148a-3p ACHE -0.43 0.74664 0.44 0.14441 miRNATAP -0.64 0 NA
8 hsa-miR-194-5p ACHE -0.66 0.56197 0.44 0.14441 MirTarget -0.38 4.0E-5 NA
9 hsa-miR-146b-5p ACO1 -0.14 0.85977 -0.31 0.60258 miRanda -0.12 9.0E-5 NA
10 hsa-miR-192-5p ACPP -0.38 0.75615 0.07 0.85556 MirTarget -0.44 0 NA
11 hsa-miR-30e-5p ACSL3 0.17 0.8725 0.19 0.70327 mirMAP -0.15 0.00409 NA
12 hsa-miR-148a-3p ACSL4 -0.43 0.74664 -0.52 0.37291 miRNATAP -0.65 0 NA
13 hsa-miR-127-3p ACSM2A 0.06 0.93463 -1.55 0.021 miRanda -0.14 0.04952 NA
14 hsa-miR-194-5p ACTR3 -0.66 0.56197 0.2 0.6915 mirMAP -0.14 0 NA
15 hsa-miR-148a-3p ACVR1 -0.43 0.74664 0.26 0.47784 miRNAWalker2 validate; miRTarBase; MirTarget; miRNATAP -0.13 0.0001 NA
16 hsa-miR-148a-3p ADAM10 -0.43 0.74664 0.21 0.60427 MirTarget -0.11 0.02275 NA
17 hsa-miR-148a-3p ADAM19 -0.43 0.74664 -0.15 0.59553 mirMAP -0.33 0 NA
18 hsa-miR-30e-5p ADAM19 0.17 0.8725 -0.15 0.59553 MirTarget -0.17 0.01281 NA
19 hsa-miR-148a-3p ADAM22 -0.43 0.74664 0.86 0.0313 MirTarget; miRNATAP -0.57 0 NA
20 hsa-miR-148a-3p ADAM23 -0.43 0.74664 -0.54 0.19066 MirTarget -0.47 0.00032 NA
21 hsa-miR-148a-3p ADAMTS15 -0.43 0.74664 0.01 0.9881 MirTarget; miRNATAP -0.41 1.0E-5 NA
22 hsa-miR-148a-3p ADAMTS18 -0.43 0.74664 -0.22 0.60955 miRNATAP -0.21 0.04667 NA
23 hsa-miR-455-3p ADAMTS18 0.05 0.95193 -0.22 0.60955 PITA -0.26 0.00421 NA
24 hsa-miR-148a-3p ADAMTS5 -0.43 0.74664 0.46 0.02501 miRNATAP -0.31 0 NA
25 hsa-miR-194-5p ADAMTS5 -0.66 0.56197 0.46 0.02501 mirMAP -0.29 0 NA
26 hsa-miR-192-5p ADARB1 -0.38 0.75615 -0.11 0.68835 mirMAP -0.13 3.0E-5 NA
27 hsa-miR-132-3p ADCY1 0.29 0.56507 -0.32 0.42912 mirMAP -0.61 0.00048 NA
28 hsa-miR-146b-5p ADCY1 -0.14 0.85977 -0.32 0.42912 mirMAP -0.41 0 NA
29 hsa-miR-132-3p ADH1A 0.29 0.56507 -1.29 0.08498 miRNAWalker2 validate -1.27 0 NA
30 hsa-miR-148a-3p ADM2 -0.43 0.74664 0.24 0.45317 mirMAP -0.43 0 NA
31 hsa-miR-148a-3p ADPRH -0.43 0.74664 -0.17 0.42396 MirTarget -0.25 0 NA
32 hsa-miR-30e-5p ADRA1D 0.17 0.8725 -0.2 0.62344 MirTarget -1.11 0 NA
33 hsa-miR-30e-5p ADRA2A 0.17 0.8725 0.01 0.986 MirTarget -0.53 0.00123 NA
34 hsa-miR-192-5p AFAP1 -0.38 0.75615 0.23 0.36456 mirMAP -0.49 0 NA
35 hsa-miR-192-5p AFAP1L1 -0.38 0.75615 0 0.98479 miRNAWalker2 validate -0.18 0 NA
36 hsa-miR-146b-5p AFAP1L2 -0.14 0.85977 0.14 0.38633 miRanda; miRNATAP -0.13 0.00063 NA
37 hsa-miR-132-3p AFF1 0.29 0.56507 0.09 0.84353 mirMAP -0.2 0.0001 NA
38 hsa-miR-192-5p AFF2 -0.38 0.75615 0.2 0.63713 mirMAP -0.51 1.0E-5 NA
39 hsa-miR-194-5p AFF2 -0.66 0.56197 0.2 0.63713 mirMAP -0.52 0 NA
40 hsa-miR-132-3p AFF4 0.29 0.56507 -0.16 0.75987 mirMAP; miRNATAP -0.24 0 NA
41 hsa-miR-455-3p AGPAT4 0.05 0.95193 0.11 0.59369 mirMAP -0.25 5.0E-5 NA
42 hsa-miR-148a-3p AHDC1 -0.43 0.74664 0.13 0.67817 miRNATAP -0.12 0.00053 NA
43 hsa-miR-215-5p AHSA2 0.07 0.90777 -0.23 0.42729 miRNAWalker2 validate -0.15 0 NA
44 hsa-miR-30e-5p AIDA 0.17 0.8725 -0 0.99937 MirTarget -0.16 0.00012 NA
45 hsa-miR-146b-5p AKAP13 -0.14 0.85977 -0.15 0.75454 miRanda -0.12 0 NA
46 hsa-miR-192-5p AKAP7 -0.38 0.75615 0.01 0.97703 miRNAWalker2 validate -0.12 0.01301 NA
47 hsa-miR-146b-5p AKAP9 -0.14 0.85977 0.09 0.84157 miRanda -0.18 0 NA
48 hsa-miR-146b-5p AKT3 -0.14 0.85977 0.23 0.34941 miRNAWalker2 validate -0.16 0.00026 NA
49 hsa-miR-455-3p ALDH1A2 0.05 0.95193 0.08 0.75414 PITA -0.21 0.00704 NA
50 hsa-miR-194-5p ALDH1L2 -0.66 0.56197 0.12 0.56553 mirMAP -0.54 0 NA
51 hsa-miR-455-3p ALPK3 0.05 0.95193 0.13 0.67222 mirMAP -0.34 0 NA
52 hsa-miR-146b-5p AMOTL2 -0.14 0.85977 0.09 0.82559 miRanda -0.14 0.0002 NA
53 hsa-miR-148a-3p AMZ1 -0.43 0.74664 0.36 0.30444 mirMAP -0.44 6.0E-5 NA
54 hsa-miR-146b-5p ANGPTL1 -0.14 0.85977 -0.62 0.06719 miRanda -0.4 0 NA
55 hsa-miR-148a-3p ANK2 -0.43 0.74664 -0.16 0.45483 MirTarget; miRNATAP -0.44 0 NA
56 hsa-miR-148a-3p ANKRD27 -0.43 0.74664 0.21 0.50133 mirMAP -0.18 0 NA
57 hsa-miR-132-3p ANKRD28 0.29 0.56507 -0.13 0.7521 miRNAWalker2 validate -0.15 2.0E-5 NA
58 hsa-miR-148a-3p ANKRD52 -0.43 0.74664 0.33 0.36636 mirMAP; miRNATAP -0.25 0 NA
59 hsa-miR-192-5p ANKRD52 -0.38 0.75615 0.33 0.36636 mirMAP -0.16 1.0E-5 NA
60 hsa-miR-148a-3p ANKS6 -0.43 0.74664 0.41 0.2121 mirMAP -0.63 0 NA
61 hsa-miR-192-5p ANLN -0.38 0.75615 0.97 0.00069 miRNAWalker2 validate -0.2 0.01824 NA
62 hsa-miR-215-5p ANLN 0.07 0.90777 0.97 0.00069 miRNAWalker2 validate -0.18 0.00495 NA
63 hsa-miR-30e-5p ANO4 0.17 0.8725 0.59 0.15302 MirTarget -0.63 1.0E-5 NA
64 hsa-miR-30e-5p ANTXR1 0.17 0.8725 0.19 0.5684 mirMAP -0.23 0.0476 NA
65 hsa-miR-30e-5p ANXA11 0.17 0.8725 0 0.99304 mirMAP -0.32 0 NA
66 hsa-miR-146b-5p ANXA3 -0.14 0.85977 0.31 0.32959 miRanda -0.29 0.00067 NA
67 hsa-miR-148a-3p ANXA4 -0.43 0.74664 0.09 0.87587 MirTarget -0.36 0 NA
68 hsa-miR-146b-5p AOC3 -0.14 0.85977 -0.24 0.51131 miRanda -0.1 0.00112 NA
69 hsa-miR-192-5p AP1S2 -0.38 0.75615 0.11 0.63521 miRNAWalker2 validate -0.33 0 NA
70 hsa-miR-192-5p AP3M2 -0.38 0.75615 0.29 0.18353 miRNAWalker2 validate -0.28 0 NA
71 hsa-miR-215-5p AP3M2 0.07 0.90777 0.29 0.18353 miRNAWalker2 validate -0.11 0 NA
72 hsa-miR-455-3p APLN 0.05 0.95193 0.54 0.04739 MirTarget; miRNATAP -0.26 0.00175 NA
73 hsa-miR-146b-5p AQP1 -0.14 0.85977 -0.48 0.33983 miRanda -0.18 0.00079 NA
74 hsa-miR-132-3p AR 0.29 0.56507 -1.03 0.00955 mirMAP -1.03 0 NA
75 hsa-miR-148a-3p ARAP2 -0.43 0.74664 -0.24 0.3858 MirTarget -0.26 0 NA
76 hsa-miR-192-5p ARF3 -0.38 0.75615 0.12 0.81302 mirMAP -0.14 0 NA
77 hsa-miR-194-5p ARHGAP24 -0.66 0.56197 -0.27 0.32543 miRNATAP -0.15 0.00266 NA
78 hsa-miR-132-3p ARHGAP32 0.29 0.56507 0.03 0.90337 miRNAWalker2 validate; miRTarBase; MirTarget; miRNATAP -0.19 0.00042 NA
79 hsa-miR-146b-5p ARHGAP6 -0.14 0.85977 -0.1 0.49053 PITA; miRanda -0.11 0.00647 NA
80 hsa-miR-192-5p ARHGEF10 -0.38 0.75615 0.12 0.55425 miRNAWalker2 validate -0.42 0 NA
81 hsa-miR-148a-3p ARHGEF17 -0.43 0.74664 0.32 0.30788 miRNATAP -0.46 0 NA
82 hsa-miR-146b-5p ARHGEF4 -0.14 0.85977 0.29 0.44593 miRanda -0.27 0.0043 NA
83 hsa-miR-30e-5p ARID3A 0.17 0.8725 0.21 0.37047 mirMAP -0.5 6.0E-5 NA
84 hsa-miR-192-5p ARID5B -0.38 0.75615 0.15 0.64543 mirMAP -0.16 2.0E-5 NA
85 hsa-miR-132-3p ARIH1 0.29 0.56507 -0.02 0.9687 MirTarget -0.11 0.0009 NA
86 hsa-miR-30e-5p ARL4A 0.17 0.8725 0.34 0.26566 MirTarget -0.21 0.00674 NA
87 hsa-miR-192-5p ARL4C -0.38 0.75615 0.09 0.80063 miRNAWalker2 validate -0.45 0 NA
88 hsa-miR-215-5p ARL4C 0.07 0.90777 0.09 0.80063 miRNAWalker2 validate -0.11 0.00494 NA
89 hsa-miR-192-5p ARNTL2 -0.38 0.75615 0.08 0.76868 miRNAWalker2 validate -0.27 0.00197 NA
90 hsa-miR-30e-5p ARPC5 0.17 0.8725 -0.04 0.94559 MirTarget -0.21 0 NA
91 hsa-miR-194-5p ASAP1 -0.66 0.56197 0.25 0.48559 MirTarget; miRNATAP -0.36 0 NA
92 hsa-miR-30e-5p ASB1 0.17 0.8725 0.17 0.54601 mirMAP -0.23 0 NA
93 hsa-miR-192-5p ASPH -0.38 0.75615 0.13 0.82595 miRNAWalker2 validate -0.11 0.02603 NA
94 hsa-miR-146b-5p ASXL2 -0.14 0.85977 0.28 0.30877 miRanda -0.12 0.01657 NA
95 hsa-miR-215-5p ATAD5 0.07 0.90777 0.44 0.01133 miRNAWalker2 validate -0.1 0.01461 NA
96 hsa-miR-148a-3p ATG4D -0.43 0.74664 0.02 0.94675 MirTarget -0.18 0 NA
97 hsa-miR-146b-5p ATP10B -0.14 0.85977 0.75 0.09634 miRanda; miRNATAP -0.27 0.00487 NA
98 hsa-miR-192-5p ATP10D -0.38 0.75615 0.15 0.55334 miRNAWalker2 validate -0.13 0.00486 NA
99 hsa-miR-148a-3p ATP11A -0.43 0.74664 0.15 0.70832 MirTarget -0.17 0.00011 NA
100 hsa-miR-455-3p ATP1B3 0.05 0.95193 0.44 0.24371 PITA -0.3 0 NA
101 hsa-miR-455-3p ATP2A3 0.05 0.95193 -0.23 0.44513 mirMAP -0.29 0 NA
102 hsa-miR-148a-3p ATP2B4 -0.43 0.74664 0.15 0.74889 MirTarget; miRNATAP -0.11 0.02111 NA
103 hsa-miR-148a-3p ATP7A -0.43 0.74664 0.39 0.04405 MirTarget; miRNATAP -0.12 0.00074 NA
104 hsa-miR-192-5p ATP8B4 -0.38 0.75615 -0.26 0.11774 MirTarget -0.11 0.01365 NA
105 hsa-miR-194-5p ATP8B4 -0.66 0.56197 -0.26 0.11774 MirTarget -0.14 0.00192 NA
106 hsa-miR-132-3p ATXN7 0.29 0.56507 -0.1 0.76036 MirTarget; miRNATAP -0.17 3.0E-5 NA
107 hsa-miR-148a-3p AURKB -0.43 0.74664 0.52 0.04694 miRNAWalker2 validate -0.53 0 NA
108 hsa-miR-192-5p B3GALNT1 -0.38 0.75615 0.34 0.05404 miRNAWalker2 validate -0.42 0 NA
109 hsa-miR-215-5p B3GALNT1 0.07 0.90777 0.34 0.05404 miRNAWalker2 validate -0.14 0.00028 NA
110 hsa-miR-146b-5p B3GNT5 -0.14 0.85977 0.47 0.09212 miRanda -0.15 0.00816 NA
111 hsa-miR-192-5p B3GNT5 -0.38 0.75615 0.47 0.09212 miRNAWalker2 validate -0.18 0.00734 NA
112 hsa-miR-148a-3p B4GALT2 -0.43 0.74664 0.05 0.91329 miRNATAP -0.13 3.0E-5 NA
113 hsa-miR-148a-3p B4GALT5 -0.43 0.74664 0.34 0.45166 MirTarget; miRNATAP -0.33 0 NA
114 hsa-miR-148a-3p BAZ2A -0.43 0.74664 0.2 0.65423 mirMAP; miRNATAP -0.15 0 NA
115 hsa-miR-146b-5p BAZ2B -0.14 0.85977 0.04 0.91052 miRanda -0.1 0.00011 NA
116 hsa-miR-192-5p BBS7 -0.38 0.75615 0.37 0.04426 miRNAWalker2 validate -0.17 0.00017 NA
117 hsa-miR-127-3p BCAS3 0.06 0.93463 -0.15 0.66767 MirTarget; PITA; miRanda; miRNATAP -0.11 0 NA
118 hsa-miR-146b-5p BCAT2 -0.14 0.85977 0.16 0.65184 miRNATAP -0.11 0.00603 NA
119 hsa-miR-148a-3p BCL2 -0.43 0.74664 -0.15 0.47322 miRNAWalker2 validate; miRTarBase -0.31 0 21455217; 23975374 MiR 148a promotes apoptosis by targeting Bcl 2 in colorectal cancer;MiR 148a regulates the growth and apoptosis in pancreatic cancer by targeting CCKBR and Bcl 2; Using western blot and luciferase activity assay CCKBR and Bcl-2 were identified as targets of miR-148a; Moreover we also found that the expression of Bcl-2 lacking in 3'UTR could abrogate the pro-apoptosis function of miR-148a
120 hsa-miR-192-5p BCL2 -0.38 0.75615 -0.15 0.47322 miRNAWalker2 validate -0.34 0 26550150 MicroRNA 192 regulates chemo resistance of lung adenocarcinoma for gemcitabine and cisplatin combined therapy by targeting Bcl 2; In this paper we try to test whether miR-192 regulates chemo-resistance in human carcinoma A549 mice model by targeting Bcl-2; MTT assay real-time RT-PCR western blotting assay were used to investigate miR-192 expression levels cell viability ratio and Bcl-2 protein expression levels; Bcl-2 mRNA and protein expression levels up-regulated in miR-192 inhibitor treated tumor; Bcl-2 is a key regulator for miR-192 related chemotherapy resistance; In this study we demonstrate that miR-192 regulates chemoresistance for gemcitabine and cisplatin combined chemotherapy in human adenocarcinoma lung cancer A549 cells and Bcl-2 is the target of miR-192
121 hsa-miR-30e-5p BCL2L15 0.17 0.8725 0.27 0.37276 MirTarget -0.37 0.00235 NA
122 hsa-miR-148a-3p BCL9L -0.43 0.74664 0.43 0.29186 mirMAP -0.25 0 NA
123 hsa-miR-30e-5p BEND3 0.17 0.8725 0.44 0.00919 mirMAP -0.35 0 NA
124 hsa-miR-146b-5p BHLHB9 -0.14 0.85977 -0.01 0.96134 miRanda -0.14 8.0E-5 NA
125 hsa-miR-192-5p BHLHE22 -0.38 0.75615 -0.48 0.14453 MirTarget; miRNATAP -0.52 0 NA
126 hsa-miR-148a-3p BHLHE41 -0.43 0.74664 0.33 0.19513 MirTarget -0.82 0 NA
127 hsa-miR-192-5p BICD1 -0.38 0.75615 0.53 0.00803 miRNAWalker2 validate -0.46 0 NA
128 hsa-miR-30e-5p BICD1 0.17 0.8725 0.53 0.00803 mirMAP -0.38 0.00055 NA
129 hsa-miR-194-5p BICD2 -0.66 0.56197 0.27 0.41368 miRNATAP -0.12 0 NA
130 hsa-miR-132-3p BLCAP 0.29 0.56507 -0.09 0.86056 MirTarget -0.32 0 NA
131 hsa-miR-192-5p BLM -0.38 0.75615 0.58 0.00887 miRNAWalker2 validate -0.2 0.00541 NA
132 hsa-miR-148a-3p BMF -0.43 0.74664 0.34 0.26423 mirMAP -0.31 0 NA
133 hsa-miR-192-5p BMP2K -0.38 0.75615 0.2 0.30864 miRNAWalker2 validate -0.16 1.0E-5 NA
134 hsa-miR-30e-5p BMP7 0.17 0.8725 0.65 0.19575 mirMAP -0.58 0.00444 NA
135 hsa-miR-146b-5p BMP8A -0.14 0.85977 0.46 0.01909 miRanda -0.12 0.02024 NA
136 hsa-miR-30e-5p BNC2 0.17 0.8725 0.09 0.69634 mirMAP -0.29 0.01003 NA
137 hsa-miR-132-3p BNIP2 0.29 0.56507 -0.05 0.88758 miRNAWalker2 validate; MirTarget; miRNATAP -0.11 0.00507 NA
138 hsa-miR-127-3p BOLA1 0.06 0.93463 0.03 0.91869 miRanda -0.14 0 NA
139 hsa-miR-127-3p BRIP1 0.06 0.93463 0.38 0.09841 miRanda -0.11 0.0302 NA
140 hsa-miR-132-3p BRWD1 0.29 0.56507 -0.11 0.7844 MirTarget -0.3 0 NA
141 hsa-miR-132-3p BTAF1 0.29 0.56507 0.02 0.95569 MirTarget -0.18 0.00186 NA
142 hsa-miR-148a-3p BTBD10 -0.43 0.74664 0.17 0.51856 MirTarget; miRNATAP -0.17 0 NA
143 hsa-miR-455-3p BTBD10 0.05 0.95193 0.17 0.51856 MirTarget -0.11 0 NA
144 hsa-miR-148a-3p BTBD3 -0.43 0.74664 0.3 0.34286 miRNAWalker2 validate; miRNATAP -0.17 1.0E-5 NA
145 hsa-miR-192-5p BTF3L4 -0.38 0.75615 0.28 0.42225 miRNAWalker2 validate -0.12 0 NA
146 hsa-miR-455-3p BTG2 0.05 0.95193 0.02 0.95118 MirTarget; PITA; miRNATAP -0.12 0.01114 NA
147 hsa-miR-455-3p BTN2A2 0.05 0.95193 -0.16 0.55588 mirMAP -0.12 0.00034 NA
148 hsa-miR-192-5p BUB1B -0.38 0.75615 0.84 0.00176 miRNAWalker2 validate -0.22 0.01192 NA
149 hsa-miR-215-5p BUB1B 0.07 0.90777 0.84 0.00176 miRNAWalker2 validate -0.16 0.00993 NA
150 hsa-miR-192-5p BVES -0.38 0.75615 0.03 0.87329 mirMAP -0.29 0 NA

Over-represented Gene Ontology Biological Process

NumGOOverlapSizeP ValueAdj. P Value
1 CELL DEVELOPMENT 191 1426 1.672e-20 7.78e-17
2 NEUROGENESIS 180 1402 2.069e-17 4.812e-14
3 TISSUE DEVELOPMENT 188 1518 1.521e-16 2.359e-13
4 REGULATION OF CELL DIFFERENTIATION 184 1492 5.154e-16 5.996e-13
5 REGULATION OF MULTICELLULAR ORGANISMAL DEVELOPMENT 198 1672 2.274e-15 2.116e-12
6 REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 206 1784 7.804e-15 6.052e-12
7 REGULATION OF ANATOMICAL STRUCTURE MORPHOGENESIS 136 1021 1.551e-14 1.031e-11
8 CARDIOVASCULAR SYSTEM DEVELOPMENT 112 788 5.169e-14 2.672e-11
9 CIRCULATORY SYSTEM DEVELOPMENT 112 788 5.169e-14 2.672e-11
10 TISSUE MORPHOGENESIS 83 533 9.042e-13 3.987e-10
11 MOVEMENT OF CELL OR SUBCELLULAR COMPONENT 154 1275 9.425e-13 3.987e-10
12 MORPHOGENESIS OF AN EPITHELIUM 68 400 1.87e-12 7.251e-10
13 NEGATIVE REGULATION OF GENE EXPRESSION 171 1493 4.359e-12 1.56e-09
14 POSITIVE REGULATION OF GENE EXPRESSION 191 1733 6.6e-12 2.194e-09
15 MUSCLE STRUCTURE DEVELOPMENT 70 432 8.927e-12 2.769e-09
16 CELLULAR COMPONENT MORPHOGENESIS 116 900 1.353e-11 3.935e-09
17 CELL MOTILITY 109 835 2.686e-11 6.944e-09
18 LOCALIZATION OF CELL 109 835 2.686e-11 6.944e-09
19 ANATOMICAL STRUCTURE FORMATION INVOLVED IN MORPHOGENESIS 120 957 3.575e-11 8.754e-09
20 HEART DEVELOPMENT 72 466 4.388e-11 9.896e-09
21 NEURON DIFFERENTIATION 112 874 4.466e-11 9.896e-09
22 ORGAN MORPHOGENESIS 108 841 8.935e-11 1.89e-08
23 SKELETAL SYSTEM DEVELOPMENT 70 455 9.976e-11 2.018e-08
24 NEGATIVE REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 98 740 1.279e-10 2.48e-08
25 INTRACELLULAR SIGNAL TRANSDUCTION 172 1572 1.556e-10 2.896e-08
26 CONNECTIVE TISSUE DEVELOPMENT 40 194 2.125e-10 3.803e-08
27 TUBE DEVELOPMENT 79 552 2.256e-10 3.887e-08
28 CELL MORPHOGENESIS INVOLVED IN DIFFERENTIATION 75 513 2.423e-10 4.027e-08
29 REGULATION OF CELL DEVELOPMENT 106 836 2.827e-10 4.536e-08
30 CENTRAL NERVOUS SYSTEM DEVELOPMENT 109 872 3.609e-10 5.598e-08
31 REGULATION OF NEURON DIFFERENTIATION 78 554 6.386e-10 9.377e-08
32 LOCOMOTION 130 1114 6.449e-10 9.377e-08
33 POSITIVE REGULATION OF BIOSYNTHETIC PROCESS 189 1805 6.652e-10 9.379e-08
34 NEGATIVE REGULATION OF NITROGEN COMPOUND METABOLIC PROCESS 164 1517 1.079e-09 1.46e-07
35 PROTEIN PHOSPHORYLATION 114 944 1.098e-09 1.46e-07
36 MESENCHYMAL CELL DIFFERENTIATION 31 134 1.204e-09 1.556e-07
37 STEM CELL DIFFERENTIATION 38 190 1.488e-09 1.871e-07
38 NEGATIVE REGULATION OF MULTICELLULAR ORGANISMAL PROCESS 117 983 1.555e-09 1.904e-07
39 POSITIVE REGULATION OF DEVELOPMENTAL PROCESS 131 1142 1.657e-09 1.977e-07
40 POSITIVE REGULATION OF MOLECULAR FUNCTION 186 1791 1.785e-09 2.077e-07
41 TUBE MORPHOGENESIS 53 323 1.938e-09 2.199e-07
42 HEAD DEVELOPMENT 91 709 2.969e-09 3.289e-07
43 CARTILAGE DEVELOPMENT 32 147 3.297e-09 3.568e-07
44 REGULATION OF CELL PROLIFERATION 160 1496 3.802e-09 4.021e-07
45 EPITHELIUM DEVELOPMENT 112 945 4.522e-09 4.676e-07
46 MESENCHYME DEVELOPMENT 37 190 5.229e-09 5.29e-07
47 REGULATION OF INTRACELLULAR SIGNAL TRANSDUCTION 172 1656 7.971e-09 7.891e-07
48 NEGATIVE REGULATION OF DEVELOPMENTAL PROCESS 98 801 8.874e-09 8.602e-07
49 REGULATION OF NERVOUS SYSTEM DEVELOPMENT 93 750 1.118e-08 1.062e-06
50 PHOSPHORYLATION 135 1228 1.359e-08 1.265e-06
51 PHOSPHATE CONTAINING COMPOUND METABOLIC PROCESS 197 1977 1.51e-08 1.377e-06
52 CELL CYCLE 142 1316 1.816e-08 1.625e-06
53 POSITIVE REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 115 1004 1.915e-08 1.681e-06
54 UROGENITAL SYSTEM DEVELOPMENT 48 299 2.275e-08 1.96e-06
55 BIOLOGICAL ADHESION 117 1032 2.537e-08 2.147e-06
56 POSITIVE REGULATION OF CATALYTIC ACTIVITY 158 1518 3.055e-08 2.538e-06
57 VASCULATURE DEVELOPMENT 65 469 3.205e-08 2.616e-06
58 MUSCLE TISSUE DEVELOPMENT 45 275 3.468e-08 2.735e-06
59 POSITIVE REGULATION OF CELL DIFFERENTIATION 98 823 3.467e-08 2.735e-06
60 GROWTH 59 410 3.615e-08 2.804e-06
61 REGULATION OF CELL ADHESION 80 629 4.086e-08 3.066e-06
62 DEVELOPMENTAL GROWTH 51 333 4.063e-08 3.066e-06
63 REGULATION OF CELL PROJECTION ORGANIZATION 73 558 5.167e-08 3.816e-06
64 EMBRYONIC ORGAN DEVELOPMENT 58 406 6.11e-08 4.442e-06
65 REGULATION OF CELL MORPHOGENESIS 72 552 7.196e-08 5.152e-06
66 EMBRYO DEVELOPMENT 103 894 8.199e-08 5.78e-06
67 NEURON DEVELOPMENT 84 687 1.084e-07 7.53e-06
68 REGULATION OF PHOSPHATIDYLINOSITOL 3 KINASE SIGNALING 28 138 1.517e-07 1.038e-05
69 REGULATION OF CELLULAR COMPONENT MOVEMENT 91 771 1.626e-07 1.096e-05
70 REGULATION OF NEURON PROJECTION DEVELOPMENT 57 408 1.711e-07 1.137e-05
71 NEURON PROJECTION DEVELOPMENT 70 545 1.989e-07 1.303e-05
72 EXTRACELLULAR STRUCTURE ORGANIZATION 46 304 2.66e-07 1.719e-05
73 EMBRYONIC MORPHOGENESIS 69 539 2.756e-07 1.756e-05
74 BLOOD VESSEL MORPHOGENESIS 52 364 2.925e-07 1.839e-05
75 CELL CYCLE PROCESS 117 1081 3.061e-07 1.899e-05
76 POSITIVE REGULATION OF NEURON DIFFERENTIATION 46 306 3.227e-07 1.976e-05
77 CELL PROLIFERATION 81 672 3.334e-07 2.015e-05
78 REGULATION OF SMALL GTPASE MEDIATED SIGNAL TRANSDUCTION 43 278 3.507e-07 2.092e-05
79 EMBRYONIC ORGAN MORPHOGENESIS 43 279 3.879e-07 2.285e-05
80 NEGATIVE REGULATION OF CELL DIFFERENTIATION 75 609 3.96e-07 2.303e-05
81 OSSIFICATION 40 251 4.037e-07 2.319e-05
82 REGULATION OF TRANSPORT 176 1804 4.164e-07 2.363e-05
83 POSITIVE REGULATION OF CELL DEVELOPMENT 62 472 4.552e-07 2.552e-05
84 POSITIVE REGULATION OF CELL PROLIFERATION 93 814 5.184e-07 2.872e-05
85 NEGATIVE REGULATION OF CELL DEATH 98 872 5.443e-07 2.98e-05
86 CYTOSKELETON ORGANIZATION 95 838 5.538e-07 2.997e-05
87 POSITIVE REGULATION OF MULTICELLULAR ORGANISMAL PROCESS 142 1395 6.018e-07 3.182e-05
88 ANGIOGENESIS 44 293 5.959e-07 3.182e-05
89 TISSUE MIGRATION 20 84 6.27e-07 3.278e-05
90 MUSCLE CELL DIFFERENTIATION 38 237 6.684e-07 3.455e-05
91 MUSCLE ORGAN DEVELOPMENT 42 277 8.233e-07 4.21e-05
92 REGULATION OF CELL MORPHOGENESIS INVOLVED IN DIFFERENTIATION 48 337 9.05e-07 4.577e-05
93 REGULATION OF CELL DEATH 147 1472 1.135e-06 5.681e-05
94 CELL PROJECTION ORGANIZATION 99 902 1.394e-06 6.901e-05
95 REGULATION OF CELL CYCLE 103 949 1.42e-06 6.956e-05
96 EMBRYO DEVELOPMENT ENDING IN BIRTH OR EGG HATCHING 68 554 1.551e-06 7.447e-05
97 MITOTIC CELL CYCLE 87 766 1.553e-06 7.447e-05
98 AMEBOIDAL TYPE CELL MIGRATION 28 154 1.576e-06 7.485e-05
99 REGULATION OF EPITHELIAL CELL PROLIFERATION 42 285 1.762e-06 8.279e-05
100 NEGATIVE REGULATION OF CELL COMMUNICATION 123 1192 1.828e-06 8.504e-05
101 REGULATION OF PROTEIN MODIFICATION PROCESS 165 1710 1.964e-06 9.05e-05
102 NEURON PROJECTION MORPHOGENESIS 53 402 2.75e-06 0.0001254
103 REGULATION OF ORGAN MORPHOGENESIS 37 242 2.986e-06 0.0001349
104 NEGATIVE REGULATION OF CELL PROLIFERATION 75 643 3.128e-06 0.0001399
105 KIDNEY EPITHELIUM DEVELOPMENT 24 125 3.215e-06 0.0001411
106 CENTRAL NERVOUS SYSTEM NEURON DEVELOPMENT 17 70 3.211e-06 0.0001411
107 SENSORY ORGAN DEVELOPMENT 61 493 4.11e-06 0.0001787
108 EPITHELIAL CELL DIFFERENTIATION 61 495 4.68e-06 0.0002016
109 RESPONSE TO ORGANIC CYCLIC COMPOUND 98 917 5.001e-06 0.0002116
110 TELENCEPHALON DEVELOPMENT 35 228 4.996e-06 0.0002116
111 REGULATION OF PHOSPHORUS METABOLIC PROCESS 155 1618 6.222e-06 0.0002608
112 EMBRYONIC DIGESTIVE TRACT DEVELOPMENT 11 33 6.618e-06 0.0002749
113 GLAND MORPHOGENESIS 20 97 6.805e-06 0.0002802
114 BRANCHING MORPHOGENESIS OF AN EPITHELIAL TUBE 24 131 7.499e-06 0.0003034
115 POSITIVE REGULATION OF CELL CYCLE 45 332 7.435e-06 0.0003034
116 MORPHOGENESIS OF A BRANCHING STRUCTURE 28 167 8.029e-06 0.000322
117 CELLULAR RESPONSE TO OXYGEN CONTAINING COMPOUND 87 799 8.369e-06 0.0003328
118 ACTIN FILAMENT BASED PROCESS 56 450 8.516e-06 0.0003358
119 REGULATION OF GTPASE ACTIVITY 76 673 8.749e-06 0.0003392
120 NEURAL CREST CELL DIFFERENTIATION 17 75 8.747e-06 0.0003392
121 POSITIVE REGULATION OF PROTEIN MODIFICATION PROCESS 115 1135 9.364e-06 0.0003601
122 REGULATION OF SYSTEM PROCESS 61 507 9.967e-06 0.0003801
123 NEGATIVE REGULATION OF RESPONSE TO STIMULUS 133 1360 1.101e-05 0.0004165
124 CELLULAR RESPONSE TO ORGANIC CYCLIC COMPOUND 57 465 1.116e-05 0.0004187
125 POSITIVE REGULATION OF CELLULAR COMPONENT ORGANIZATION 116 1152 1.135e-05 0.0004197
126 TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 80 724 1.137e-05 0.0004197
127 PROSTATE GLAND DEVELOPMENT 12 41 1.156e-05 0.0004235
128 PALLIUM DEVELOPMENT 26 153 1.306e-05 0.0004747
129 CELLULAR RESPONSE TO LIPID 56 457 1.342e-05 0.0004841
130 REGULATION OF CELL CYCLE PROCESS 65 558 1.469e-05 0.0005259
131 SMALL GTPASE MEDIATED SIGNAL TRANSDUCTION 46 352 1.544e-05 0.0005484
132 REGULATION OF CELL CYCLE PHASE TRANSITION 43 321 1.577e-05 0.000556
133 EPITHELIAL TO MESENCHYMAL TRANSITION 14 56 1.64e-05 0.0005736
134 REGULATION OF DENDRITE DEVELOPMENT 22 120 1.754e-05 0.000609
135 HEART MORPHOGENESIS 32 212 1.774e-05 0.0006115
136 DENDRITE DEVELOPMENT 17 79 1.819e-05 0.0006177
137 REGULATION OF TRANSFERASE ACTIVITY 98 946 1.811e-05 0.0006177
138 REGULATION OF RAS PROTEIN SIGNAL TRANSDUCTION 29 184 1.894e-05 0.0006386
139 CELLULAR RESPONSE TO ACID CHEMICAL 28 175 1.973e-05 0.0006606
140 CENTRAL NERVOUS SYSTEM NEURON DIFFERENTIATION 27 166 2.039e-05 0.0006778
141 NEGATIVE REGULATION OF LOCOMOTION 37 263 2.058e-05 0.000679
142 CELL PART MORPHOGENESIS 71 633 2.154e-05 0.0007058
143 FOREBRAIN DEVELOPMENT 46 357 2.216e-05 0.0007211
144 CELL MORPHOGENESIS INVOLVED IN NEURON DIFFERENTIATION 47 368 2.278e-05 0.0007361
145 POSITIVE REGULATION OF CELL COMMUNICATION 145 1532 2.354e-05 0.0007555
146 NON CANONICAL WNT SIGNALING PATHWAY 24 140 2.387e-05 0.0007608
147 NEGATIVE REGULATION OF GROWTH 34 236 2.671e-05 0.0008397
148 REGULATION OF MITOTIC CELL CYCLE 56 468 2.663e-05 0.0008397
149 REGULATION OF OSSIFICATION 28 178 2.715e-05 0.0008479
150 CELLULAR RESPONSE TO ALCOHOL 21 115 2.873e-05 0.0008912
151 POSITIVE REGULATION OF TRANSFERASE ACTIVITY 69 616 2.928e-05 0.0009023
152 POSITIVE REGULATION OF NERVOUS SYSTEM DEVELOPMENT 53 437 3.009e-05 0.000921
153 AMINOGLYCAN BIOSYNTHETIC PROCESS 20 107 3.115e-05 0.0009474
154 NEGATIVE REGULATION OF CELL GROWTH 27 170 3.152e-05 0.0009525
155 POSITIVE REGULATION OF PROTEIN METABOLIC PROCESS 141 1492 3.31e-05 0.0009899
156 GLAND DEVELOPMENT 49 395 3.319e-05 0.0009899
157 CHONDROCYTE DIFFERENTIATION 14 60 3.793e-05 0.001124
158 ORGAN GROWTH 15 68 4.106e-05 0.001209
159 NEGATIVE REGULATION OF DEVELOPMENTAL GROWTH 17 84 4.208e-05 0.001231
160 STRIATED MUSCLE CELL DIFFERENTIATION 27 173 4.32e-05 0.001256
161 CELL SUBSTRATE ADHESION 26 164 4.524e-05 0.001308
162 NEGATIVE REGULATION OF CELL ADHESION 32 223 4.922e-05 0.001414
163 ACTOMYOSIN STRUCTURE ORGANIZATION 16 77 5.01e-05 0.00143
164 BONE DEVELOPMENT 25 156 5.24e-05 0.001487
165 FOREBRAIN NEURON DEVELOPMENT 10 34 5.932e-05 0.001643
166 POSITIVE REGULATION OF PHOSPHATE METABOLIC PROCESS 103 1036 5.909e-05 0.001643
167 NEURAL PRECURSOR CELL PROLIFERATION 15 70 5.873e-05 0.001643
168 POSITIVE REGULATION OF PHOSPHORUS METABOLIC PROCESS 103 1036 5.909e-05 0.001643
169 DIGESTIVE SYSTEM DEVELOPMENT 24 148 6.048e-05 0.001665
170 WNT SIGNALING PATHWAY 44 351 6.411e-05 0.001744
171 MORPHOGENESIS OF A POLARIZED EPITHELIUM 9 28 6.404e-05 0.001744
172 RESPONSE TO ALCOHOL 45 362 6.509e-05 0.001761
173 POSITIVE REGULATION OF HYDROLASE ACTIVITY 92 905 6.593e-05 0.001773
174 REGULATION OF CARTILAGE DEVELOPMENT 14 63 6.748e-05 0.001794
175 DEVELOPMENTAL GROWTH INVOLVED IN MORPHOGENESIS 19 104 6.746e-05 0.001794
176 CARDIAC MUSCLE TISSUE DEVELOPMENT 23 140 6.951e-05 0.001838
177 PATTERN SPECIFICATION PROCESS 50 418 7.119e-05 0.001872
178 REGULATION OF KINASE ACTIVITY 81 776 7.467e-05 0.001952
179 REGULATION OF DENDRITIC SPINE DEVELOPMENT 13 56 7.547e-05 0.001953
180 APPENDAGE DEVELOPMENT 26 169 7.596e-05 0.001953
181 LIMB DEVELOPMENT 26 169 7.596e-05 0.001953
182 POSITIVE REGULATION OF LOCOMOTION 50 420 8.034e-05 0.002054
183 CELLULAR RESPONSE TO ENDOGENOUS STIMULUS 100 1008 8.217e-05 0.002089
184 REGULATION OF ACTIN FILAMENT BASED PROCESS 40 312 8.284e-05 0.002095
185 PROSTATE GLAND MORPHOGENESIS 8 23 8.722e-05 0.002194
186 INOSITOL LIPID MEDIATED SIGNALING 21 124 9.037e-05 0.002261
187 ENDOTHELIAL CELL MIGRATION 13 57 9.174e-05 0.002283
188 RESPONSE TO VITAMIN 18 98 9.667e-05 0.002393
189 POSITIVE REGULATION OF CELL MORPHOGENESIS INVOLVED IN DIFFERENTIATION 25 162 9.839e-05 0.002422
190 MESONEPHROS DEVELOPMENT 17 90 0.0001045 0.002559
191 ENZYME LINKED RECEPTOR PROTEIN SIGNALING PATHWAY 73 689 0.0001057 0.002574
192 SINGLE ORGANISM CELL ADHESION 53 459 0.0001107 0.002683
193 CARDIAC MUSCLE CELL DIFFERENTIATION 15 74 0.0001149 0.00277
194 REGULATION OF DENDRITIC SPINE MORPHOGENESIS 9 30 0.0001172 0.002811
195 RESPONSE TO WOUNDING 62 563 0.0001189 0.002837
196 RESPONSE TO ACID CHEMICAL 40 319 0.0001344 0.003174
197 NEGATIVE REGULATION OF CELL CYCLE PHASE TRANSITION 23 146 0.000134 0.003174
198 GLIOGENESIS 26 175 0.0001366 0.003211
199 HINDBRAIN DEVELOPMENT 22 137 0.0001397 0.003264
200 REGULATION OF MUSCLE SYSTEM PROCESS 28 195 0.0001403 0.003264
201 NEURON MIGRATION 19 110 0.0001469 0.003401
202 SISTER CHROMATID SEGREGATION 26 176 0.0001502 0.003459
203 POSITIVE REGULATION OF CELL CYCLE PROCESS 33 247 0.0001545 0.003541
204 LUNG MORPHOGENESIS 11 45 0.000163 0.003664
205 SPROUTING ANGIOGENESIS 11 45 0.000163 0.003664
206 CELL FATE COMMITMENT 31 227 0.0001621 0.003664
207 CELL JUNCTION ASSEMBLY 21 129 0.0001612 0.003664
208 REGULATION OF CELLULAR LOCALIZATION 120 1277 0.0001651 0.003693
209 SUBSTRATE ADHESION DEPENDENT CELL SPREADING 10 38 0.0001666 0.003707
210 RESPIRATORY SYSTEM DEVELOPMENT 28 197 0.0001673 0.003707
211 REGULATION OF ORGANELLE ORGANIZATION 112 1178 0.0001739 0.003835
212 RESPONSE TO OXYGEN CONTAINING COMPOUND 128 1381 0.0001794 0.003938
213 REGULATION OF MORPHOGENESIS OF A BRANCHING STRUCTURE 12 53 0.0001826 0.003977
214 NEURAL TUBE DEVELOPMENT 23 149 0.0001829 0.003977
215 REGULATION OF OSTEOBLAST DIFFERENTIATION 19 112 0.0001876 0.004059
216 POSITIVE REGULATION OF CELL PROJECTION ORGANIZATION 38 303 0.0001947 0.004193
217 CELLULAR RESPONSE TO ORGANIC SUBSTANCE 164 1848 0.0001966 0.004216
218 REGULATION OF CELL GROWTH 46 391 0.0002002 0.004273
219 REGULATION OF CHONDROCYTE DIFFERENTIATION 11 46 0.0002012 0.004274
220 POSITIVE REGULATION OF KINASE ACTIVITY 54 482 0.000208 0.004398
221 RENAL TUBULE DEVELOPMENT 15 78 0.000213 0.004484
222 CELL DIVISION 52 460 0.0002171 0.00455
223 REGULATION OF ANATOMICAL STRUCTURE SIZE 53 472 0.0002241 0.004676
224 REGULATION OF HEART CONTRACTION 30 221 0.000228 0.004736
225 RESPONSE TO ABIOTIC STIMULUS 99 1024 0.0002293 0.004743
226 RESPONSE TO VITAMIN A 7 20 0.0002335 0.004803
227 REGULATION OF BLOOD CIRCULATION 37 295 0.0002343 0.004803
228 SKELETAL SYSTEM MORPHOGENESIS 28 201 0.0002356 0.004809
229 CEREBRAL CORTEX DEVELOPMENT 18 105 0.0002396 0.004868
230 REGULATION OF MUSCLE CELL DIFFERENTIATION 23 152 0.000247 0.004996
231 SKIN EPIDERMIS DEVELOPMENT 14 71 0.0002608 0.005254
232 CELLULAR RESPONSE TO OXYGEN LEVELS 22 143 0.0002626 0.005267
233 EPIDERMAL GROWTH FACTOR RECEPTOR SIGNALING PATHWAY 12 55 0.0002646 0.005285
234 NEGATIVE REGULATION OF EPITHELIAL CELL PROLIFERATION 19 115 0.000267 0.005286
235 NEPHRON DEVELOPMENT 19 115 0.000267 0.005286
236 FAT CELL DIFFERENTIATION 18 106 0.0002706 0.005334
237 REPRODUCTIVE SYSTEM DEVELOPMENT 47 408 0.0002791 0.005479
238 PHOSPHATIDYLINOSITOL METABOLIC PROCESS 27 193 0.0002816 0.005506
239 CELL MIGRATION INVOLVED IN SPROUTING ANGIOGENESIS 6 15 0.0002867 0.005582
240 NEGATIVE REGULATION OF CELL CYCLE PROCESS 29 214 0.0002961 0.005741
241 DIGESTIVE TRACT MORPHOGENESIS 11 48 0.0003006 0.005755
242 MYOFIBRIL ASSEMBLY 11 48 0.0003006 0.005755
243 EPITHELIAL CELL PROLIFERATION 16 89 0.0002992 0.005755
244 RESPONSE TO ENDOGENOUS STIMULUS 132 1450 0.0003045 0.005807
245 CELL GROWTH 21 135 0.0003075 0.00584
246 REGULATION OF DEVELOPMENTAL GROWTH 36 289 0.0003227 0.006104
247 HEART VALVE DEVELOPMENT 9 34 0.0003356 0.006323
248 MUCOPOLYSACCHARIDE METABOLIC PROCESS 18 108 0.0003431 0.006437
249 LIPID PHOSPHORYLATION 17 99 0.0003458 0.006461
250 RESPONSE TO LIPID 87 888 0.0003558 0.006621
251 CARDIAC SEPTUM MORPHOGENESIS 11 49 0.000364 0.006749
252 EPITHELIAL CELL DEVELOPMENT 26 186 0.0003664 0.006765
253 CELLULAR RESPONSE TO RETINOIC ACID 13 65 0.0003704 0.006812
254 INTEGRIN MEDIATED SIGNALING PATHWAY 15 82 0.0003764 0.006895
255 REGULATION OF RHO PROTEIN SIGNAL TRANSDUCTION 18 109 0.0003853 0.007031
256 REGULATION OF MUSCLE CONTRACTION 22 147 0.0003901 0.00709
257 MUSCLE CELL DEVELOPMENT 20 128 0.0003987 0.007219
258 REGULATION OF DENDRITE MORPHOGENESIS 14 74 0.0004082 0.007358
259 ORGANELLE LOCALIZATION 47 415 0.0004096 0.007358
260 REGULATION OF CATION TRANSMEMBRANE TRANSPORT 28 208 0.0004163 0.007451
261 REGULATION OF CELLULAR COMPONENT SIZE 40 337 0.000423 0.007535
262 EYE DEVELOPMENT 39 326 0.0004243 0.007535
263 DEVELOPMENTAL PROCESS INVOLVED IN REPRODUCTION 63 602 0.0004267 0.007549
264 REGULATION OF ESTABLISHMENT OF PLANAR POLARITY 18 110 0.000432 0.007593
265 EXTRACELLULAR MATRIX ASSEMBLY 6 16 0.0004325 0.007593
266 TUBE FORMATION 20 129 0.0004423 0.007737
267 SOMATIC STEM CELL DIVISION 7 22 0.0004554 0.007936
268 PROSTATE GLAND GROWTH 5 11 0.0004714 0.008185
269 TAXIS 51 464 0.0004823 0.008331
270 SISTER CHROMATID COHESION 18 111 0.0004834 0.008331
271 NEPHRON EPITHELIUM DEVELOPMENT 16 93 0.0004995 0.008577
272 EPIDERMIS MORPHOGENESIS 8 29 0.0005293 0.008891
273 REGULATION OF CELL CYCLE G2 M PHASE TRANSITION 12 59 0.0005249 0.008891
274 AGING 33 264 0.0005272 0.008891
275 STEM CELL DIVISION 8 29 0.0005293 0.008891
276 NEUROBLAST PROLIFERATION 8 29 0.0005293 0.008891
277 POSITIVE REGULATION OF NEURON PROJECTION DEVELOPMENT 30 232 0.0005267 0.008891
278 REGULATION OF PROTEIN LOCALIZATION 91 950 0.0005504 0.009213
279 RESPONSE TO NUTRIENT 26 191 0.0005539 0.009238
280 POSITIVE REGULATION OF INTRACELLULAR SIGNAL TRANSDUCTION 85 876 0.00056 0.009307
281 NEURAL TUBE FORMATION 16 94 0.0005647 0.00935
282 RESPONSE TO INORGANIC SUBSTANCE 52 479 0.0005703 0.009409
283 REGULATION OF GROWTH 65 633 0.0005789 0.009518
284 REGULATION OF STEM CELL DIFFERENTIATION 18 113 0.0006023 0.009869
NumGOOverlapSizeP ValueAdj. P Value
1 NUCLEIC ACID BINDING TRANSCRIPTION FACTOR ACTIVITY 155 1199 2.58e-15 2.397e-12
2 CYTOSKELETAL PROTEIN BINDING 108 819 1.794e-11 8.333e-09
3 SEQUENCE SPECIFIC DNA BINDING 127 1037 4.514e-11 1.398e-08
4 REGULATORY REGION NUCLEIC ACID BINDING 105 818 1.699e-10 3.156e-08
5 RNA POLYMERASE II TRANSCRIPTION FACTOR ACTIVITY SEQUENCE SPECIFIC DNA BINDING 87 629 1.613e-10 3.156e-08
6 MACROMOLECULAR COMPLEX BINDING 155 1399 5.805e-10 8.987e-08
7 DOUBLE STRANDED DNA BINDING 97 764 1.561e-09 2.071e-07
8 TRANSCRIPTIONAL ACTIVATOR ACTIVITY RNA POLYMERASE II TRANSCRIPTION REGULATORY REGION SEQUENCE SPECIFIC BINDING 50 315 1.699e-08 1.974e-06
9 TRANSCRIPTION FACTOR ACTIVITY RNA POLYMERASE II CORE PROMOTER PROXIMAL REGION SEQUENCE SPECIFIC BINDING 51 328 2.457e-08 2.536e-06
10 KINASE ACTIVITY 100 842 2.852e-08 2.65e-06
11 ENZYME BINDING 175 1737 5.142e-08 4.343e-06
12 PROTEIN KINASE ACTIVITY 80 640 8.627e-08 6.679e-06
13 TRANSCRIPTIONAL ACTIVATOR ACTIVITY RNA POLYMERASE II CORE PROMOTER PROXIMAL REGION SEQUENCE SPECIFIC BINDING 38 226 1.94e-07 1.386e-05
14 PROTEIN COMPLEX BINDING 105 935 2.191e-07 1.454e-05
15 RIBONUCLEOTIDE BINDING 181 1860 3.304e-07 2.046e-05
16 WNT ACTIVATED RECEPTOR ACTIVITY 10 22 6.21e-07 3.606e-05
17 TRANSCRIPTION FACTOR BINDING 66 524 8.941e-07 4.886e-05
18 ADENYL NUCLEOTIDE BINDING 149 1514 2.193e-06 0.0001132
19 ACTIN BINDING 52 393 3.063e-06 0.0001423
20 PROTEIN SERINE THREONINE KINASE ACTIVITY 57 445 2.919e-06 0.0001423
21 WNT PROTEIN BINDING 11 31 3.286e-06 0.0001454
22 PROTEIN DOMAIN SPECIFIC BINDING 73 624 3.802e-06 0.0001606
23 KINASE BINDING 71 606 4.892e-06 0.0001976
24 TRANSFERASE ACTIVITY TRANSFERRING PHOSPHORUS CONTAINING GROUPS 103 992 1.002e-05 0.000388
25 CORE PROMOTER PROXIMAL REGION DNA BINDING 48 371 1.329e-05 0.000494
26 TRANSCRIPTION FACTOR ACTIVITY PROTEIN BINDING 67 588 2.222e-05 0.000794
27 EXTRACELLULAR MATRIX BINDING 13 51 2.615e-05 0.0008997
28 RHO GUANYL NUCLEOTIDE EXCHANGE FACTOR ACTIVITY 16 77 5.01e-05 0.001662
29 CALCIUM ION BINDING 74 697 8.896e-05 0.00285
30 GUANYL NUCLEOTIDE EXCHANGE FACTOR ACTIVITY 39 303 9.28e-05 0.002874
31 SH3 DOMAIN BINDING 20 116 0.000102 0.002962
32 CHROMATIN BINDING 51 435 0.0001011 0.002962
33 ION CHANNEL BINDING 19 111 0.0001662 0.004678
34 HISTONE DEACETYLASE BINDING 18 105 0.0002396 0.006546
NumGOOverlapSizeP ValueAdj. P Value
1 CELL JUNCTION 140 1151 6.863e-12 4.008e-09
2 PERINUCLEAR REGION OF CYTOPLASM 87 642 4.595e-10 1.342e-07
3 CYTOSKELETON 200 1967 2.268e-09 4.414e-07
4 ANCHORING JUNCTION 69 489 5.75e-09 8.395e-07
5 CELL SUBSTRATE JUNCTION 59 398 1.214e-08 1.418e-06
6 CELL PROJECTION 181 1786 1.906e-08 1.855e-06
7 AXON 55 418 1.907e-06 0.0001237
8 SYNAPSE 86 754 1.501e-06 0.0001237
9 NEURON PROJECTION 102 942 1.779e-06 0.0001237
10 CELL PROJECTION PART 102 946 2.153e-06 0.0001257
11 KINESIN COMPLEX 15 55 2.542e-06 0.0001295
12 CELL CELL JUNCTION 51 383 3.16e-06 0.0001295
13 PLASMA MEMBRANE REGION 100 929 2.922e-06 0.0001295
14 CELL LEADING EDGE 48 350 2.686e-06 0.0001295
15 MEMBRANE REGION 117 1134 3.326e-06 0.0001295
16 LAMELLIPODIUM 29 172 4.974e-06 0.0001815
17 ACTIN CYTOSKELETON 56 444 5.696e-06 0.0001957
18 FILOPODIUM 19 94 1.548e-05 0.0005023
19 PROTEIN COMPLEX INVOLVED IN CELL ADHESION 10 30 1.746e-05 0.0005366
20 GOLGI APPARATUS 138 1445 2.434e-05 0.0007107
21 NEURON PART 123 1265 3.111e-05 0.0008653
22 HETEROCHROMATIN 15 67 3.412e-05 0.0009058
23 MICROTUBULE ASSOCIATED COMPLEX 24 145 4.312e-05 0.001095
24 I BAND 21 121 6.265e-05 0.001525
25 GOLGI APPARATUS PART 91 893 6.614e-05 0.001545
26 CYTOSKELETAL PART 134 1436 9.337e-05 0.002097
27 CONTRACTILE FIBER 30 211 9.902e-05 0.002142
28 SYNAPSE PART 66 610 0.0001223 0.00255
29 CELL DIVISION SITE 12 52 0.0001504 0.00303
30 EXCITATORY SYNAPSE 28 197 0.0001673 0.003257
31 POSTSYNAPSE 45 378 0.0001788 0.003368
32 MICROTUBULE CYTOSKELETON 103 1068 0.0001883 0.003436
33 EXTRACELLULAR MATRIX COMPONENT 20 125 0.0002896 0.004974
34 SARCOLEMMA 20 125 0.0002896 0.004974
35 CHROMOSOME CENTROMERIC REGION 25 174 0.0003087 0.005017
36 SPINDLE MIDZONE 8 27 0.0003093 0.005017
37 SPINDLE 36 289 0.0003227 0.005094
38 CELL SURFACE 76 757 0.0004065 0.006247
39 MICROTUBULE 46 405 0.0004406 0.006598
40 PIGMENT GRANULE 17 103 0.0005568 0.008129
41 MIDBODY 20 132 0.0005988 0.00853
42 PODOSOME 7 23 0.0006165 0.008572
43 EXTRACELLULAR MATRIX 47 426 0.0007263 0.009865

Over-represented Pathway

NumPathwayPathviewOverlapSizeP ValueAdj. P Value
1 hsa04510_Focal_adhesion 35 200 2.165e-07 3.896e-05
2 hsa04810_Regulation_of_actin_cytoskeleton 34 214 3.134e-06 0.0002821
3 hsa04390_Hippo_signaling_pathway 26 154 1.471e-05 0.0008294
4 hsa04012_ErbB_signaling_pathway 18 87 1.843e-05 0.0008294
5 hsa04310_Wnt_signaling_pathway 24 151 8.386e-05 0.003019
6 hsa04512_ECM.receptor_interaction 16 85 0.0001724 0.004633
7 hsa04360_Axon_guidance 21 130 0.0001802 0.004633
8 hsa04070_Phosphatidylinositol_signaling_system 14 78 0.0007108 0.01599
9 hsa04151_PI3K_AKT_signaling_pathway 40 351 0.0009444 0.0188
10 hsa04110_Cell_cycle 19 128 0.001045 0.0188
11 hsa04916_Melanogenesis 16 101 0.001258 0.02058
12 hsa04014_Ras_signaling_pathway 28 236 0.002902 0.04353
13 hsa04666_Fc_gamma_R.mediated_phagocytosis 14 95 0.004846 0.0671
14 hsa04914_Progesterone.mediated_oocyte_maturation 13 87 0.005777 0.07428
15 hsa04520_Adherens_junction 11 73 0.01001 0.1202
16 hsa04722_Neurotrophin_signaling_pathway 16 127 0.01234 0.1389
17 hsa00562_Inositol_phosphate_metabolism 9 57 0.01415 0.1436
18 hsa00532_Glycosaminoglycan_biosynthesis_._chondroitin_sulfate 5 22 0.01436 0.1436
19 hsa00510_N.Glycan_biosynthesis 8 49 0.01667 0.1579
20 hsa04141_Protein_processing_in_endoplasmic_reticulum 19 168 0.0201 0.1809
21 hsa04320_Dorso.ventral_axis_formation 5 25 0.02448 0.2099
22 hsa04270_Vascular_smooth_muscle_contraction 14 116 0.02581 0.2112
23 hsa04660_T_cell_receptor_signaling_pathway 13 108 0.03154 0.2431
24 hsa04020_Calcium_signaling_pathway 19 177 0.03241 0.2431
25 hsa04010_MAPK_signaling_pathway 26 268 0.04304 0.3099
26 hsa04114_Oocyte_meiosis 13 114 0.04589 0.3177
27 hsa04350_TGF.beta_signaling_pathway 10 85 0.0623 0.4051
28 hsa04960_Aldosterone.regulated_sodium_reabsorption 6 42 0.06301 0.4051
29 hsa04662_B_cell_receptor_signaling_pathway 9 75 0.0674 0.4184
30 hsa04973_Carbohydrate_digestion_and_absorption 6 44 0.07575 0.4487
31 hsa00533_Glycosaminoglycan_biosynthesis_._keratan_sulfate 3 15 0.07728 0.4487
32 hsa04340_Hedgehog_signaling_pathway 7 56 0.08405 0.4728
33 hsa04664_Fc_epsilon_RI_signaling_pathway 9 79 0.08726 0.476
34 hsa00270_Cysteine_and_methionine_metabolism 5 36 0.09462 0.4907
35 hsa04115_p53_signaling_pathway 8 69 0.09542 0.4907
36 hsa04974_Protein_digestion_and_absorption 9 81 0.09837 0.4918
37 hsa03440_Homologous_recombination 4 28 0.1191 0.5512
38 hsa00630_Glyoxylate_and_dicarboxylate_metabolism 3 18 0.1194 0.5512
39 hsa00670_One_carbon_pool_by_folate 3 18 0.1194 0.5512
40 hsa04971_Gastric_acid_secretion 8 74 0.1289 0.5801
41 hsa04514_Cell_adhesion_molecules_.CAMs. 13 136 0.1346 0.5907
42 hsa04150_mTOR_signaling_pathway 6 52 0.1399 0.5936
43 hsa00512_Mucin_type_O.Glycan_biosynthesis 4 30 0.1436 0.5936
44 hsa04910_Insulin_signaling_pathway 13 138 0.1455 0.5936
45 hsa04912_GnRH_signaling_pathway 10 101 0.1484 0.5936
46 hsa00564_Glycerophospholipid_metabolism 8 80 0.176 0.6885
47 hsa00410_beta.Alanine_metabolism 3 22 0.1854 0.7101
48 hsa04710_Circadian_rhythm_._mammal 3 23 0.2032 0.7463
49 hsa04062_Chemokine_signaling_pathway 16 189 0.2159 0.7763
50 hsa00920_Sulfur_metabolism 2 13 0.22 0.7763
51 hsa04130_SNARE_interactions_in_vesicular_transport 4 36 0.227 0.7856
52 hsa04972_Pancreatic_secretion 9 101 0.2482 0.8161
53 hsa04380_Osteoclast_differentiation 11 128 0.2537 0.8161
54 hsa04970_Salivary_secretion 8 89 0.2581 0.8161
55 hsa00534_Glycosaminoglycan_biosynthesis_._heparan_sulfate 3 26 0.2584 0.8161
56 hsa00601_Glycosphingolipid_biosynthesis_._lacto_and_neolacto_series 3 26 0.2584 0.8161
57 hsa00330_Arginine_and_proline_metabolism 5 54 0.3049 0.9352
58 hsa04144_Endocytosis 16 203 0.3065 0.9352
59 hsa04920_Adipocytokine_signaling_pathway 6 68 0.3158 0.9475
60 hsa00360_Phenylalanine_metabolism 2 17 0.3233 0.9541
61 hsa04630_Jak.STAT_signaling_pathway 12 155 0.3637 1
62 hsa00260_Glycine._serine_and_threonine_metabolism 3 32 0.3725 1
63 hsa00514_Other_types_of_O.glycan_biosynthesis 4 46 0.3824 1
64 hsa04640_Hematopoietic_cell_lineage 7 88 0.3909 1
65 hsa04670_Leukocyte_transendothelial_migration 9 117 0.401 1
66 hsa04210_Apoptosis 7 89 0.4023 1
67 hsa04540_Gap_junction 7 90 0.4136 1
68 hsa04370_VEGF_signaling_pathway 6 76 0.4145 1
69 hsa04530_Tight_junction 10 133 0.4185 1
70 hsa04260_Cardiac_muscle_contraction 6 77 0.4268 1
71 hsa04672_Intestinal_immune_network_for_IgA_production 4 49 0.4293 1
72 hsa00830_Retinol_metabolism 5 64 0.442 1
73 hsa00051_Fructose_and_mannose_metabolism 3 36 0.4469 1
74 hsa00910_Nitrogen_metabolism 2 23 0.47 1
75 hsa04964_Proximal_tubule_bicarbonate_reclamation 2 23 0.47 1
76 hsa04120_Ubiquitin_mediated_proteolysis 10 139 0.4742 1
77 hsa03015_mRNA_surveillance_pathway 6 83 0.4996 1
78 hsa04610_Complement_and_coagulation_cascades 5 69 0.5086 1
79 hsa00563_Glycosylphosphatidylinositol.GPI..anchor_biosynthesis 2 25 0.5145 1
80 hsa04720_Long.term_potentiation 5 70 0.5216 1
81 hsa04976_Bile_secretion 5 71 0.5344 1
82 hsa00350_Tyrosine_metabolism 3 41 0.5345 1
83 hsa00030_Pentose_phosphate_pathway 2 27 0.5566 1
84 hsa00052_Galactose_metabolism 2 27 0.5566 1
85 hsa00071_Fatty_acid_metabolism 3 43 0.5673 1
86 hsa03050_Proteasome 3 45 0.5986 1
87 hsa00020_Citrate_cycle_.TCA_cycle. 2 30 0.6146 1
88 hsa04330_Notch_signaling_pathway 3 47 0.6284 1
89 hsa00250_Alanine._aspartate_and_glutamate_metabolism 2 32 0.65 1
90 hsa00561_Glycerolipid_metabolism 3 50 0.6701 1
91 hsa04140_Regulation_of_autophagy 2 34 0.6827 1
92 hsa04620_Toll.like_receptor_signaling_pathway 6 102 0.7006 1
93 hsa03320_PPAR_signaling_pathway 4 70 0.7097 1
94 hsa04730_Long.term_depression 4 70 0.7097 1
95 hsa03030_DNA_replication 2 36 0.7129 1
96 hsa04650_Natural_killer_cell_mediated_cytotoxicity 8 136 0.714 1
97 hsa00600_Sphingolipid_metabolism 2 40 0.766 1
98 hsa04621_NOD.like_receptor_signaling_pathway 3 59 0.7743 1
99 hsa04612_Antigen_processing_and_presentation 4 78 0.7856 1
100 hsa00380_Tryptophan_metabolism 2 42 0.7892 1
101 hsa00310_Lysine_degradation 2 44 0.8104 1
102 hsa04962_Vasopressin.regulated_water_reabsorption 2 44 0.8104 1
103 hsa00240_Pyrimidine_metabolism 5 99 0.8116 1
104 hsa04145_Phagosome 8 156 0.84 1
105 hsa00520_Amino_sugar_and_nucleotide_sugar_metabolism 2 48 0.8471 1
106 hsa00480_Glutathione_metabolism 2 50 0.8629 1
107 hsa00980_Metabolism_of_xenobiotics_by_cytochrome_P450 3 71 0.8697 1
108 hsa03018_RNA_degradation 3 71 0.8697 1
109 hsa04742_Taste_transduction 2 52 0.8772 1
110 hsa00982_Drug_metabolism_._cytochrome_P450 3 73 0.8815 1
111 hsa00140_Steroid_hormone_biosynthesis 2 57 0.9072 1
112 hsa04146_Peroxisome 3 79 0.9116 1
113 hsa00010_Glycolysis_._Gluconeogenesis 2 65 0.9412 1
114 hsa03013_RNA_transport 6 152 0.951 1
115 hsa03010_Ribosome 3 92 0.9543 1
116 hsa04622_RIG.I.like_receptor_signaling_pathway 2 71 0.9586 1
117 hsa00230_Purine_metabolism 6 162 0.9678 1
118 hsa04142_Lysosome 3 121 0.9905 1
119 hsa03040_Spliceosome 2 128 0.9988 1
120 hsa00190_Oxidative_phosphorylation 2 132 0.999 1
121 hsa04740_Olfactory_transduction 2 388 1 1

Quest ID: d6e5d13ab6fac0f77483ea069e2e0a02