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show label of nodes with degree >=

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This regulatory network was inferred from the input dataset. The miRNAs and mRNAs are presented as round and rectangle nodes respectively. The numerical value popped up upon mouse over the gene node is the log2 transformed fold-change of the gene expression between the two groups. All of the nodes are clickable, and the detailed information of the miRNAs/mRNAs and related cancer pathway will be displayed in another window. The edges between nodes are supported by both interactions (predicted or experimentally verified) and correlations learnt from cancer dataset. The numerical value popped up upon mouse over the edge is the correlation beat value (effect size) between the two nodes. The experimental evidences of the edges reported in previous cancer studies are highlighted by red/orange color. All of these information can be accessed by the "mouse-over" action. This network shows a full map of the miRNA-mRNA regulation of the input gene list(s), and the hub miRNAs (with the high network degree/betweenness centrality) would be the potential cancer drivers or tumor suppressors. The full result table can be accessed in the "Regulations" tab.

"miRNACancerMAP" is also a network visualization tool for users to draw their regulatory network by personal customization. Users can set the complexity of the network by limiting the number of nodes or edges. And the color of the nodes can be defined by different categories of the mRNAs and miRNAs, such as Gene-Ontology, pathway, and expression status. Users can also select to use network degree or network betweenness centrality to define the node size. And edges can be black or colored by the correlation. Purple edge means negative correlation (mostly found between miRNA and mRNA), and blue edge means positive correlation (found in PPI or miRNA-miRNA sponge effect). We can also add the protein-protein interactions (PPI) into the network. This result will show the cluster of genes regulated by some specific miRNAs. Additionally, miRNA-miRNA edges can be added by the "miRNA sponge" button, presenting some clusters of miRNAs that have the interactions via sponge effect.

miRNA-gene regulations

(Download full result)

Num microRNA           Gene miRNA log2FC miRNA pvalue Gene log2FC Gene pvalue Interaction Correlation beta Correlation P-value PMID Reported in cancer studies
1 hsa-miR-129-5p PRSS23 -0.52 0.22258 -1.29 1.0E-5 miRanda; mirMAP -0.12 0.00061 NA
2 hsa-miR-192-5p PRSS23 2.69 0 -1.29 1.0E-5 miRNAWalker2 validate -0.31 0 NA
3 hsa-miR-215-5p PRSS23 2.31 0 -1.29 1.0E-5 miRNAWalker2 validate -0.13 1.0E-5 NA
4 hsa-miR-30d-3p PRSS23 0.98 4.0E-5 -1.29 1.0E-5 mirMAP -0.31 0 NA
5 hsa-miR-30e-3p PRSS23 -0.22 0.23538 -1.29 1.0E-5 mirMAP -0.41 0 NA
6 hsa-miR-32-3p PRSS23 2.02 0 -1.29 1.0E-5 mirMAP -0.27 0 NA
7 hsa-miR-330-5p PRSS23 1.15 0 -1.29 1.0E-5 miRNATAP -0.17 0.00638 NA
8 hsa-miR-361-3p PRSS23 1.07 0 -1.29 1.0E-5 MirTarget -0.24 0.00325 NA
9 hsa-miR-361-5p PRSS23 0.97 0 -1.29 1.0E-5 miRanda -0.69 0 NA
10 hsa-miR-532-5p PRSS23 1.56 0 -1.29 1.0E-5 PITA; miRNATAP -0.31 0 NA
11 hsa-miR-590-3p PRSS23 2.59 0 -1.29 1.0E-5 miRanda; mirMAP -0.32 0 NA
12 hsa-miR-664a-3p PRSS23 0.63 0.0052 -1.29 1.0E-5 mirMAP -0.35 0 NA
13 hsa-miR-7-1-3p PRSS23 1.85 0 -1.29 1.0E-5 mirMAP -0.39 0 NA
14 hsa-miR-944 PRSS23 2.91 0 -1.29 1.0E-5 mirMAP -0.15 0 NA

Over-represented Gene Ontology Biological Process

NumGOOverlapSizeP ValueAdj. P Value
NumGOOverlapSizeP ValueAdj. P Value
NumGOOverlapSizeP ValueAdj. P Value

Over-represented Pathway

NumPathwayPathviewOverlapSizeP ValueAdj. P Value

lncRNA-mediated sponge

(Download full result)

Num lncRNA miRNAs           miRNAs count     Gene Sponge regulatory network lncRNA log2FC lncRNA pvalue Gene log2FC Gene pvalue lncRNA-gene Pearson correlation
1 MIR143HG hsa-miR-129-5p;hsa-miR-192-5p;hsa-miR-215-5p;hsa-miR-30d-3p;hsa-miR-30e-3p;hsa-miR-330-5p;hsa-miR-361-3p;hsa-miR-532-5p;hsa-miR-590-3p;hsa-miR-664a-3p;hsa-miR-7-1-3p;hsa-miR-944 12 PRSS23 Sponge network -4.237 0 -1.288 1.0E-5 0.482
2 LINC00702 hsa-miR-129-5p;hsa-miR-192-5p;hsa-miR-215-5p;hsa-miR-30d-3p;hsa-miR-30e-3p;hsa-miR-330-5p;hsa-miR-361-5p;hsa-miR-532-5p;hsa-miR-590-3p;hsa-miR-664a-3p;hsa-miR-7-1-3p 11 PRSS23 Sponge network -2.704 0 -1.288 1.0E-5 0.474
3 RP11-166D19.1 hsa-miR-129-5p;hsa-miR-192-5p;hsa-miR-215-5p;hsa-miR-30d-3p;hsa-miR-30e-3p;hsa-miR-32-3p;hsa-miR-330-5p;hsa-miR-361-3p;hsa-miR-361-5p;hsa-miR-532-5p;hsa-miR-590-3p;hsa-miR-664a-3p;hsa-miR-7-1-3p;hsa-miR-944 14 PRSS23 Sponge network -3.855 0 -1.288 1.0E-5 0.472
4 MAGI2-AS3 hsa-miR-192-5p;hsa-miR-215-5p;hsa-miR-30d-3p;hsa-miR-30e-3p;hsa-miR-32-3p;hsa-miR-330-5p;hsa-miR-361-5p;hsa-miR-532-5p;hsa-miR-590-3p;hsa-miR-664a-3p;hsa-miR-7-1-3p;hsa-miR-944 12 PRSS23 Sponge network -2.414 0 -1.288 1.0E-5 0.428
5 HAND2-AS1 hsa-miR-129-5p;hsa-miR-192-5p;hsa-miR-215-5p;hsa-miR-30d-3p;hsa-miR-30e-3p;hsa-miR-32-3p;hsa-miR-330-5p;hsa-miR-361-3p;hsa-miR-361-5p;hsa-miR-590-3p;hsa-miR-664a-3p;hsa-miR-7-1-3p;hsa-miR-944 13 PRSS23 Sponge network -5.605 0 -1.288 1.0E-5 0.408
6 ADAMTS9-AS1 hsa-miR-129-5p;hsa-miR-192-5p;hsa-miR-215-5p;hsa-miR-30d-3p;hsa-miR-30e-3p;hsa-miR-330-5p;hsa-miR-361-3p;hsa-miR-361-5p;hsa-miR-532-5p;hsa-miR-590-3p;hsa-miR-664a-3p;hsa-miR-7-1-3p;hsa-miR-944 13 PRSS23 Sponge network -7.614 0 -1.288 1.0E-5 0.378
7 NR2F1-AS1 hsa-miR-192-5p;hsa-miR-215-5p;hsa-miR-30d-3p;hsa-miR-30e-3p;hsa-miR-330-5p;hsa-miR-361-3p;hsa-miR-361-5p;hsa-miR-532-5p;hsa-miR-590-3p;hsa-miR-664a-3p;hsa-miR-7-1-3p;hsa-miR-944 12 PRSS23 Sponge network -1.881 0 -1.288 1.0E-5 0.363
8 MEG3 hsa-miR-192-5p;hsa-miR-215-5p;hsa-miR-30d-3p;hsa-miR-30e-3p;hsa-miR-32-3p;hsa-miR-330-5p;hsa-miR-361-3p;hsa-miR-361-5p;hsa-miR-7-1-3p;hsa-miR-944 10 PRSS23 Sponge network -2.367 0 -1.288 1.0E-5 0.347
9 LINC00327 hsa-miR-192-5p;hsa-miR-215-5p;hsa-miR-30d-3p;hsa-miR-30e-3p;hsa-miR-32-3p;hsa-miR-330-5p;hsa-miR-361-3p;hsa-miR-361-5p;hsa-miR-532-5p;hsa-miR-590-3p;hsa-miR-664a-3p;hsa-miR-944 12 PRSS23 Sponge network -1.951 0.01135 -1.288 1.0E-5 0.332
10 FENDRR hsa-miR-129-5p;hsa-miR-192-5p;hsa-miR-215-5p;hsa-miR-32-3p;hsa-miR-330-5p;hsa-miR-361-3p;hsa-miR-361-5p;hsa-miR-532-5p;hsa-miR-590-3p;hsa-miR-7-1-3p;hsa-miR-944 11 PRSS23 Sponge network -4.793 0 -1.288 1.0E-5 0.319

Quest ID: 0be09fa06bba9aeac5e36f722602a04f