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This regulatory network was inferred from the input dataset. The miRNAs and mRNAs are presented as round and rectangle nodes respectively. The numerical value popped up upon mouse over the gene node is the log2 transformed fold-change of the gene expression between the two groups. All of the nodes are clickable, and the detailed information of the miRNAs/mRNAs and related cancer pathway will be displayed in another window. The edges between nodes are supported by both interactions (predicted or experimentally verified) and correlations learnt from cancer dataset. The numerical value popped up upon mouse over the edge is the correlation beat value (effect size) between the two nodes. The experimental evidences of the edges reported in previous cancer studies are highlighted by red/orange color. All of these information can be accessed by the "mouse-over" action. This network shows a full map of the miRNA-mRNA regulation of the input gene list(s), and the hub miRNAs (with the high network degree/betweenness centrality) would be the potential cancer drivers or tumor suppressors. The full result table can be accessed in the "Regulations" tab.

"miRNACancerMAP" is also a network visualization tool for users to draw their regulatory network by personal customization. Users can set the complexity of the network by limiting the number of nodes or edges. And the color of the nodes can be defined by different categories of the mRNAs and miRNAs, such as Gene-Ontology, pathway, and expression status. Users can also select to use network degree or network betweenness centrality to define the node size. And edges can be black or colored by the correlation. Purple edge means negative correlation (mostly found between miRNA and mRNA), and blue edge means positive correlation (found in PPI or miRNA-miRNA sponge effect). We can also add the protein-protein interactions (PPI) into the network. This result will show the cluster of genes regulated by some specific miRNAs. Additionally, miRNA-miRNA edges can be added by the "miRNA sponge" button, presenting some clusters of miRNAs that have the interactions via sponge effect.

miRNA-gene regulations

(Download full result)

Num microRNA           Gene miRNA log2FC miRNA pvalue Gene log2FC Gene pvalue Interaction Correlation beta Correlation P-value PMID Reported in cancer studies
1 hsa-miR-103a-3p SMAD7 0.54 2.0E-5 -1.03 0 miRNAWalker2 validate -0.18 0.00234 NA
2 hsa-miR-106a-5p SMAD7 1.39 6.0E-5 -1.03 0 miRNATAP -0.13 0 NA
3 hsa-miR-106b-5p SMAD7 1.47 0 -1.03 0 miRNATAP -0.2 0 27619676; 25286029; 22286770 MiR 106b promotes migration and invasion through enhancing EMT via downregulation of Smad 7 in Kazakh's esophageal squamous cell carcinoma; To understand the regulation between miR-106b and Smad 7 qRT-PCR and western blot were performed; Smad 7 was confirmed as a downstream target of miR-106b in our experimental setting; Our results indicated that miR-106b can promote migration and invasion of ESCC cells through enhancing EMT process via downregulation of Smad 7 suggesting that miR-106b can be a potential molecular phenotype in ESCC metastases;Smad7 which inhibits transforming growth factor-β TGF-β/Smad signaling as a target of the miR-106b family was downregulated in CD44+ cells;The miR 106b 25 cluster targets Smad7 activates TGF β signaling and induces EMT and tumor initiating cell characteristics downstream of Six1 in human breast cancer
4 hsa-miR-16-5p SMAD7 0.75 0 -1.03 0 miRNAWalker2 validate; MirTarget; miRNATAP -0.15 0.00092 NA
5 hsa-miR-17-5p SMAD7 2.07 0 -1.03 0 TargetScan; miRNATAP -0.17 0 NA
6 hsa-miR-182-5p SMAD7 3.22 0 -1.03 0 miRNATAP -0.13 0 NA
7 hsa-miR-20a-5p SMAD7 2.65 0 -1.03 0 miRNATAP -0.13 0 NA
8 hsa-miR-21-3p SMAD7 2.54 0 -1.03 0 MirTarget -0.12 0.00014 23372687; 27185036; 26531758 Furthermore the expression of MSH2 and SMAD7 two important molecules involving TGF-β pathway was restored following miR-21 knockdown in both MCF-7 and Hs578T breast cancer cells;MicroRNA 21 Regulates Non Small Cell Lung Cancer Cell Invasion and Chemo Sensitivity through SMAD7; We performed bioinformatics analyses on the binding of microRNA-21 miR-21 to the 3'-UTR of SMAD7 mRNA and verified the biological effects of this binding using promoter luciferase reporter assay; Furthermore expression of miR-21 was found to be inhibited by Carboplatin and bioinformatics analyses showed that miR-21 targeted the 3'-UTR of SMAD7 mRNA to inhibit its translation which was confirmed by luciferase reporter assay; Carboplatin may upregulate SMAD7 through suppression of miR-21 to inhibit TGFβ receptor signaling mediated NSCLC cell invasion;MicroRNA 21 induces breast cancer cell invasion and migration by suppressing smad7 via EGF and TGF β pathways; The present study was undertaken to determine the association of miR-21 smad7 EGF and TGF-β with breast cancer cell invasion and migration and to identify the molecular mechanisms involved using immunohistochemistry and western blot analysis; Smad7 was confirmed to be a direct target of miR-21 by luciferase reporter and western blot assays; The downregulation of smad7 by miR-21 or sismad7 enhanced EGF-dependent invasion and migration as well as TGF-β-dependent invasion and migration; The actions of miR-21 were abrogated by expressing a modified smad7 cDNA resistant to miR-21; In conclusion our results demonstrated that plasma miR-21 levels may serve as a diagnostic marker in breast cancers whereas miR-21 promotes breast cancer cell proliferation and invasion by suppressing smad7 which enhances EGF and TGF-β pathways
9 hsa-miR-21-5p SMAD7 4.38 0 -1.03 0 miRNAWalker2 validate; MirTarget; miRNATAP -0.15 0 23372687; 27185036; 26531758 Furthermore the expression of MSH2 and SMAD7 two important molecules involving TGF-β pathway was restored following miR-21 knockdown in both MCF-7 and Hs578T breast cancer cells;MicroRNA 21 Regulates Non Small Cell Lung Cancer Cell Invasion and Chemo Sensitivity through SMAD7; We performed bioinformatics analyses on the binding of microRNA-21 miR-21 to the 3'-UTR of SMAD7 mRNA and verified the biological effects of this binding using promoter luciferase reporter assay; Furthermore expression of miR-21 was found to be inhibited by Carboplatin and bioinformatics analyses showed that miR-21 targeted the 3'-UTR of SMAD7 mRNA to inhibit its translation which was confirmed by luciferase reporter assay; Carboplatin may upregulate SMAD7 through suppression of miR-21 to inhibit TGFβ receptor signaling mediated NSCLC cell invasion;MicroRNA 21 induces breast cancer cell invasion and migration by suppressing smad7 via EGF and TGF β pathways; The present study was undertaken to determine the association of miR-21 smad7 EGF and TGF-β with breast cancer cell invasion and migration and to identify the molecular mechanisms involved using immunohistochemistry and western blot analysis; Smad7 was confirmed to be a direct target of miR-21 by luciferase reporter and western blot assays; The downregulation of smad7 by miR-21 or sismad7 enhanced EGF-dependent invasion and migration as well as TGF-β-dependent invasion and migration; The actions of miR-21 were abrogated by expressing a modified smad7 cDNA resistant to miR-21; In conclusion our results demonstrated that plasma miR-21 levels may serve as a diagnostic marker in breast cancers whereas miR-21 promotes breast cancer cell proliferation and invasion by suppressing smad7 which enhances EGF and TGF-β pathways
10 hsa-miR-25-3p SMAD7 0.36 0.01637 -1.03 0 miRNAWalker2 validate; MirTarget; miRNATAP -0.17 0.00029 23435373 MicroRNA 25 functions as a potential tumor suppressor in colon cancer by targeting Smad7; Furthermore bioinformatic predictions and experimental validation were used to identify Smad7 as a direct target of miR-25; Functional reverse experiments indicated that the antitumor effects of miR-25 were probably mediated by its repression of Smad7; These results suggest that miR-25 may function as a tumor suppressor by targeting Smad7 in colon cancer
11 hsa-miR-590-3p SMAD7 0.84 0.00129 -1.03 0 miRanda -0.17 0 NA
12 hsa-miR-590-5p SMAD7 2.07 0 -1.03 0 MirTarget; PITA; miRanda; miRNATAP -0.15 0 NA
13 hsa-miR-671-5p SMAD7 2.24 0 -1.03 0 PITA -0.12 2.0E-5 NA
14 hsa-miR-93-5p SMAD7 1.51 0 -1.03 0 miRNATAP -0.18 0 25371073 Mothers against decapentaplegic homolog 7 Smad7 as an essential molecular protein for nuclear accumulation of β-catenin in the canonical Wnt signaling pathway is predicted as a putative target gene of miR-93 by the silico method and demonstrated that it may be suppressed by targeting its 3'UTR; These findings showed that miR-93 suppresses colorectal cancer development via downregulating Wnt/β-catenin at least in part by targeting Smad7
15 hsa-miR-98-5p SMAD7 1.17 0 -1.03 0 miRNAWalker2 validate -0.15 2.0E-5 NA

Over-represented Gene Ontology Biological Process

NumGOOverlapSizeP ValueAdj. P Value
1 CELL CYCLE PROCESS 28 1081 1.807e-18 8.407e-15
2 REGULATION OF CELL CYCLE 26 949 1.15e-17 2.676e-14
3 CELL CYCLE 29 1316 2.744e-17 4.256e-14
4 REGULATION OF CELL CYCLE PROCESS 19 558 1.505e-14 1.751e-11
5 DNA METABOLIC PROCESS 21 758 2.704e-14 2.516e-11
6 MITOTIC CELL CYCLE 21 766 3.32e-14 2.575e-11
7 CELL CYCLE PHASE TRANSITION 14 255 1.126e-13 7.483e-11
8 DNA REPAIR 17 480 2.453e-13 1.427e-10
9 CELLULAR RESPONSE TO DNA DAMAGE STIMULUS 19 720 1.401e-12 7.244e-10
10 REGULATION OF PROTEIN MODIFICATION PROCESS 27 1710 1.677e-12 7.802e-10
11 REGULATION OF MITOTIC CELL CYCLE 16 468 2.355e-12 9.96e-10
12 CHROMOSOME ORGANIZATION 21 1009 6.638e-12 2.574e-09
13 SIGNAL TRANSDUCTION BY P53 CLASS MEDIATOR 10 127 1.359e-11 4.864e-09
14 SIGNAL TRANSDUCTION IN RESPONSE TO DNA DAMAGE 9 96 3.135e-11 1.042e-08
15 REGULATION OF CELL CYCLE PHASE TRANSITION 13 321 4.291e-11 1.331e-08
16 REGULATION OF DNA METABOLIC PROCESS 13 340 8.756e-11 2.546e-08
17 ANAPHASE PROMOTING COMPLEX DEPENDENT CATABOLIC PROCESS 8 77 1.806e-10 4.942e-08
18 POSITIVE REGULATION OF BIOSYNTHETIC PROCESS 25 1805 2.591e-10 6.346e-08
19 PHOSPHORYLATION 21 1228 2.572e-10 6.346e-08
20 REGULATION OF LIGASE ACTIVITY 9 130 4.87e-10 1.133e-07
21 CELLULAR RESPONSE TO STRESS 23 1565 5.557e-10 1.231e-07
22 CELL CYCLE CHECKPOINT 10 194 8.971e-10 1.897e-07
23 POSITIVE REGULATION OF CELL CYCLE 12 332 9.509e-10 1.922e-07
24 POSITIVE REGULATION OF PROTEIN MODIFICATION BY SMALL PROTEIN CONJUGATION OR REMOVAL 10 196 9.913e-10 1.922e-07
25 PHOSPHATE CONTAINING COMPOUND METABOLIC PROCESS 25 1977 1.751e-09 3.259e-07
26 NEGATIVE REGULATION OF NITROGEN COMPOUND METABOLIC PROCESS 22 1517 1.92e-09 3.435e-07
27 REGULATION OF PROTEIN MODIFICATION BY SMALL PROTEIN CONJUGATION OR REMOVAL 11 280 2.136e-09 3.681e-07
28 REGULATION OF CELL CYCLE ARREST 8 108 2.784e-09 4.627e-07
29 CELL DIVISION 13 460 3.491e-09 5.601e-07
30 RESPONSE TO ABIOTIC STIMULUS 18 1024 4.356e-09 6.756e-07
31 POSITIVE REGULATION OF PROTEIN METABOLIC PROCESS 21 1492 8.553e-09 1.284e-06
32 REGULATION OF TRANSFERASE ACTIVITY 17 946 9.294e-09 1.31e-06
33 POSITIVE REGULATION OF CELL CYCLE PROCESS 10 247 9.205e-09 1.31e-06
34 POSITIVE REGULATION OF CELL CYCLE ARREST 7 85 1.378e-08 1.886e-06
35 CELL CYCLE G2 M PHASE TRANSITION 8 138 1.939e-08 2.578e-06
36 NEGATIVE REGULATION OF PROTEIN MODIFICATION BY SMALL PROTEIN CONJUGATION OR REMOVAL 8 139 2.052e-08 2.653e-06
37 POSITIVE REGULATION OF PROTEIN MODIFICATION PROCESS 18 1135 2.152e-08 2.707e-06
38 POSITIVE REGULATION OF GENE EXPRESSION 22 1733 2.219e-08 2.717e-06
39 DNA INTEGRITY CHECKPOINT 8 146 3.015e-08 3.597e-06
40 MITOTIC DNA INTEGRITY CHECKPOINT 7 100 4.297e-08 4.998e-06
41 PROTEIN PHOSPHORYLATION 16 944 6.226e-08 7.065e-06
42 ORGANELLE FISSION 12 496 8.242e-08 9.003e-06
43 POSITIVE REGULATION OF LIGASE ACTIVITY 7 110 8.32e-08 9.003e-06
44 PEPTIDYL AMINO ACID MODIFICATION 15 841 8.983e-08 9.087e-06
45 CELL CYCLE G1 S PHASE TRANSITION 7 111 8.857e-08 9.087e-06
46 G1 S TRANSITION OF MITOTIC CELL CYCLE 7 111 8.857e-08 9.087e-06
47 NEGATIVE REGULATION OF PROTEIN MODIFICATION PROCESS 13 616 1.09e-07 1.079e-05
48 INTRACELLULAR SIGNAL TRANSDUCTION 20 1572 1.148e-07 1.113e-05
49 PROTEIN MODIFICATION BY SMALL PROTEIN CONJUGATION OR REMOVAL 15 873 1.458e-07 1.384e-05
50 G1 DNA DAMAGE CHECKPOINT 6 73 1.605e-07 1.494e-05
51 RESPONSE TO DRUG 11 431 1.78e-07 1.624e-05
52 POSITIVE REGULATION OF DNA METABOLIC PROCESS 8 185 1.885e-07 1.687e-05
53 POSITIVE REGULATION OF CELLULAR PROTEIN CATABOLIC PROCESS 8 192 2.505e-07 2.2e-05
54 NEGATIVE REGULATION OF GENE EXPRESSION 19 1493 2.604e-07 2.244e-05
55 POSITIVE REGULATION OF CELL PROLIFERATION 14 814 4.027e-07 3.407e-05
56 MITOTIC CELL CYCLE CHECKPOINT 7 139 4.133e-07 3.434e-05
57 NEGATIVE REGULATION OF PROTEIN METABOLIC PROCESS 16 1087 4.232e-07 3.454e-05
58 DNA REPLICATION 8 208 4.61e-07 3.698e-05
59 NEGATIVE REGULATION OF CELL CYCLE PROCESS 8 214 5.719e-07 4.51e-05
60 REGULATION OF CELL CYCLE G1 S PHASE TRANSITION 7 147 6.039e-07 4.683e-05
61 REGULATION OF PROTEIN CATABOLIC PROCESS 10 393 7.003e-07 5.342e-05
62 REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 20 1784 8.78e-07 6.589e-05
63 REGULATION OF PHOSPHORUS METABOLIC PROCESS 19 1618 8.928e-07 6.594e-05
64 NEGATIVE REGULATION OF CELL CYCLE G1 S PHASE TRANSITION 6 98 9.296e-07 6.758e-05
65 RESPONSE TO RADIATION 10 413 1.098e-06 7.859e-05
66 REGULATION OF SIGNAL TRANSDUCTION BY P53 CLASS MEDIATOR 7 162 1.162e-06 8.19e-05
67 REGULATION OF PROTEIN UBIQUITINATION INVOLVED IN UBIQUITIN DEPENDENT PROTEIN CATABOLIC PROCESS 6 103 1.246e-06 8.655e-05
68 REGULATION OF CELL PROLIFERATION 18 1496 1.323e-06 9.055e-05
69 INNATE IMMUNE RESPONSE ACTIVATING CELL SURFACE RECEPTOR SIGNALING PATHWAY 6 106 1.475e-06 9.753e-05
70 PROTEIN POLYUBIQUITINATION 8 243 1.488e-06 9.753e-05
71 REGULATION OF MULTICELLULAR ORGANISMAL DEVELOPMENT 19 1672 1.465e-06 9.753e-05
72 NEGATIVE REGULATION OF CELL CYCLE 10 433 1.68e-06 0.0001086
73 NUCLEOTIDE EXCISION REPAIR 6 113 2.145e-06 0.0001368
74 MICROTUBULE CYTOSKELETON ORGANIZATION 9 348 2.319e-06 0.0001458
75 NEGATIVE REGULATION OF TRANSFERASE ACTIVITY 9 351 2.488e-06 0.0001544
76 POSITIVE REGULATION OF PROTEIN CATABOLIC PROCESS 8 263 2.682e-06 0.0001642
77 POSITIVE REGULATION OF PROTEOLYSIS 9 363 3.274e-06 0.0001978
78 MISMATCH REPAIR 4 31 3.381e-06 0.0001991
79 PROTEASOMAL PROTEIN CATABOLIC PROCESS 8 271 3.348e-06 0.0001991
80 REGULATION OF CELLULAR PROTEIN CATABOLIC PROCESS 8 274 3.632e-06 0.0002112
81 INTRINSIC APOPTOTIC SIGNALING PATHWAY IN RESPONSE TO DNA DAMAGE 5 71 3.978e-06 0.0002285
82 NEGATIVE REGULATION OF MITOTIC CELL CYCLE 7 199 4.56e-06 0.0002587
83 REGULATION OF RESPONSE TO STRESS 17 1468 4.707e-06 0.0002639
84 POSITIVE REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 14 1004 4.774e-06 0.0002645
85 ACTIVATION OF INNATE IMMUNE RESPONSE 7 204 5.368e-06 0.0002939
86 POSITIVE REGULATION OF TRANSFERASE ACTIVITY 11 616 5.809e-06 0.0003143
87 REGULATION OF RNA STABILITY 6 139 7.124e-06 0.000381
88 DNA RECOMBINATION 7 215 7.573e-06 0.0004004
89 FC EPSILON RECEPTOR SIGNALING PATHWAY 6 142 8.053e-06 0.000421
90 PROTEOLYSIS 15 1208 8.422e-06 0.0004354
91 NIK NF KAPPAB SIGNALING 5 83 8.6e-06 0.0004397
92 NEGATIVE REGULATION OF CELL CYCLE PHASE TRANSITION 6 146 9.443e-06 0.0004776
93 REGULATION OF DNA DEPENDENT DNA REPLICATION 4 41 1.061e-05 0.0005308
94 MACROMOLECULAR COMPLEX ASSEMBLY 16 1398 1.111e-05 0.0005497
95 CHROMATIN MODIFICATION 10 539 1.161e-05 0.0005685
96 POSITIVE REGULATION OF RESPONSE TO STIMULUS 19 1929 1.194e-05 0.0005787
97 REGULATION OF DNA BINDING 5 93 1.5e-05 0.0007196
98 CENTROSOME CYCLE 4 45 1.545e-05 0.0007297
99 NEGATIVE REGULATION OF CELLULAR COMPONENT ORGANIZATION 11 684 1.553e-05 0.0007297
100 SOMATIC DIVERSIFICATION OF IMMUNE RECEPTORS VIA SOMATIC MUTATION 3 15 1.589e-05 0.0007318
101 DNA DAMAGE RESPONSE SIGNAL TRANSDUCTION RESULTING IN TRANSCRIPTION 3 15 1.589e-05 0.0007318
102 REGULATION OF DNA REPLICATION 6 161 1.649e-05 0.0007522
103 REGULATION OF MICROTUBULE BASED PROCESS 7 243 1.677e-05 0.0007565
104 POSITIVE REGULATION OF IMMUNE RESPONSE 10 563 1.691e-05 0.0007565
105 POSITIVE REGULATION OF INNATE IMMUNE RESPONSE 7 246 1.815e-05 0.0008041
106 DOUBLE STRAND BREAK REPAIR 6 165 1.895e-05 0.0008318
107 PURINE CONTAINING COMPOUND SALVAGE 3 16 1.95e-05 0.0008403
108 COVALENT CHROMATIN MODIFICATION 8 345 1.944e-05 0.0008403
109 DNA DEPENDENT DNA REPLICATION 5 99 2.033e-05 0.0008678
110 PROTEIN CATABOLIC PROCESS 10 579 2.15e-05 0.0009096
111 REGULATION OF PROTEOLYSIS 11 711 2.222e-05 0.0009312
112 REGULATION OF INNATE IMMUNE RESPONSE 8 357 2.483e-05 0.001032
113 CELLULAR RESPONSE TO ORGANIC SUBSTANCE 18 1848 2.523e-05 0.001039
114 MITOTIC NUCLEAR DIVISION 8 361 2.689e-05 0.001097
115 AGING 7 264 2.854e-05 0.00115
116 REGULATION OF CATABOLIC PROCESS 11 731 2.867e-05 0.00115
117 POSTREPLICATION REPAIR 4 54 3.207e-05 0.001264
118 NEGATIVE REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 11 740 3.206e-05 0.001264
119 CHROMOSOME SEGREGATION 7 272 3.453e-05 0.001339
120 REGULATION OF CELL DIVISION 7 272 3.453e-05 0.001339
121 CIRCADIAN REGULATION OF GENE EXPRESSION 4 57 3.975e-05 0.001529
122 PROTEIN UBIQUITINATION 10 629 4.344e-05 0.001657
123 SOMATIC RECOMBINATION OF IMMUNOGLOBULIN GENE SEGMENTS 3 21 4.577e-05 0.001731
124 TUMOR NECROSIS FACTOR MEDIATED SIGNALING PATHWAY 5 118 4.735e-05 0.001777
125 POSITIVE REGULATION OF CATABOLIC PROCESS 8 395 5.085e-05 0.001883
126 NEGATIVE REGULATION OF MOLECULAR FUNCTION 13 1079 5.098e-05 0.001883
127 POSITIVE REGULATION OF MITOTIC CELL CYCLE 5 123 5.773e-05 0.002115
128 MICROTUBULE BASED PROCESS 9 522 5.841e-05 0.002123
129 SIGNAL TRANSDUCTION BY PROTEIN PHOSPHORYLATION 8 404 5.956e-05 0.002148
130 NUCLEOTIDE EXCISION REPAIR DNA DAMAGE RECOGNITION 3 23 6.066e-05 0.002171
131 POSITIVE REGULATION OF MOLECULAR FUNCTION 17 1791 6.238e-05 0.002216
132 RESPONSE TO UV 5 126 6.475e-05 0.002282
133 FC RECEPTOR SIGNALING PATHWAY 6 206 6.568e-05 0.002297
134 INTERSPECIES INTERACTION BETWEEN ORGANISMS 10 662 6.665e-05 0.002297
135 SYMBIOSIS ENCOMPASSING MUTUALISM THROUGH PARASITISM 10 662 6.665e-05 0.002297
136 CHROMATIN ORGANIZATION 10 663 6.75e-05 0.002309
137 NEGATIVE REGULATION OF CELLULAR RESPONSE TO TRANSFORMING GROWTH FACTOR BETA STIMULUS 4 66 7.09e-05 0.002373
138 NUCLEOBASE CONTAINING SMALL MOLECULE METABOLIC PROCESS 9 535 7.054e-05 0.002373
139 NEGATIVE REGULATION OF TRANSFORMING GROWTH FACTOR BETA RECEPTOR SIGNALING PATHWAY 4 66 7.09e-05 0.002373
140 POSITIVE REGULATION OF CELL CYCLE PHASE TRANSITION 4 68 7.972e-05 0.002649
141 PEPTIDYL LYSINE MODIFICATION 7 312 8.203e-05 0.002705
142 PROTEIN COMPLEX BIOGENESIS 13 1132 8.314e-05 0.002705
143 PROTEIN COMPLEX ASSEMBLY 13 1132 8.314e-05 0.002705
144 MITOTIC SPINDLE ORGANIZATION 4 69 8.441e-05 0.002709
145 REGULATION OF CELL DEATH 15 1472 8.44e-05 0.002709
146 NEGATIVE REGULATION OF CYTOSKELETON ORGANIZATION 6 221 9.677e-05 0.003084
147 TRANSCRIPTION COUPLED NUCLEOTIDE EXCISION REPAIR 4 73 0.0001052 0.00333
148 NON CANONICAL WNT SIGNALING PATHWAY 5 140 0.0001066 0.003352
149 NUCLEOTIDE BINDING DOMAIN LEUCINE RICH REPEAT CONTAINING RECEPTOR SIGNALING PATHWAY 3 28 0.0001109 0.003442
150 DNA SYNTHESIS INVOLVED IN DNA REPAIR 4 74 0.0001109 0.003442
151 NUCLEAR CHROMOSOME SEGREGATION 6 228 0.0001148 0.003538
152 POSITIVE REGULATION OF CATALYTIC ACTIVITY 15 1518 0.0001192 0.003649
153 REGULATION OF IMMUNE RESPONSE 11 858 0.000121 0.00368
154 SOMATIC DIVERSIFICATION OF IMMUNOGLOBULINS 3 29 0.0001234 0.00368
155 POSTTRANSCRIPTIONAL REGULATION OF GENE EXPRESSION 8 448 0.0001221 0.00368
156 DNA REPLICATION INITIATION 3 29 0.0001234 0.00368
157 RESPONSE TO IONIZING RADIATION 5 145 0.0001258 0.003727
158 T CELL RECEPTOR SIGNALING PATHWAY 5 146 0.0001299 0.003801
159 RESPONSE TO TUMOR NECROSIS FACTOR 6 233 0.0001293 0.003801
160 POSITIVE REGULATION OF IMMUNE SYSTEM PROCESS 11 867 0.0001327 0.003858
161 NEGATIVE REGULATION OF RESPONSE TO STIMULUS 14 1360 0.0001368 0.003954
162 NUCLEOSIDE MONOPHOSPHATE METABOLIC PROCESS 6 239 0.0001485 0.004264
163 INTRINSIC APOPTOTIC SIGNALING PATHWAY 5 152 0.0001569 0.004451
164 MEIOTIC CELL CYCLE PROCESS 5 152 0.0001569 0.004451
165 REGULATION OF CENTROSOME DUPLICATION 3 32 0.0001663 0.004688
166 SOMATIC CELL DNA RECOMBINATION 3 33 0.0001824 0.005023
167 SOMATIC DIVERSIFICATION OF IMMUNE RECEPTORS VIA GERMLINE RECOMBINATION WITHIN A SINGLE LOCUS 3 33 0.0001824 0.005023
168 MICROTUBULE ORGANIZING CENTER ORGANIZATION 4 84 0.0001814 0.005023
169 CYTOPLASMIC PATTERN RECOGNITION RECEPTOR SIGNALING PATHWAY 3 33 0.0001824 0.005023
170 RESPONSE TO PURINE CONTAINING COMPOUND 5 158 0.0001879 0.005144
171 POSITIVE REGULATION OF DNA REPLICATION 4 86 0.0001987 0.005406
172 REGULATION OF NUCLEAR DIVISION 5 163 0.0002172 0.005694
173 REGULATION OF CELLULAR AMINE METABOLIC PROCESS 4 88 0.0002171 0.005694
174 MEIOSIS I 4 88 0.0002171 0.005694
175 RESPONSE TO ORGANIC CYCLIC COMPOUND 11 917 0.0002163 0.005694
176 NEGATIVE REGULATION OF CANONICAL WNT SIGNALING PATHWAY 5 162 0.0002111 0.005694
177 POSITIVE REGULATION OF DEFENSE RESPONSE 7 364 0.0002126 0.005694
178 RESPONSE TO IRON ION 3 35 0.0002178 0.005694
179 GLYCOSYL COMPOUND METABOLIC PROCESS 7 368 0.0002272 0.005906
180 REGULATION OF KINASE ACTIVITY 10 776 0.0002443 0.006315
181 INTRACELLULAR RECEPTOR SIGNALING PATHWAY 5 168 0.0002499 0.006424
182 POSITIVE REGULATION OF DNA REPAIR 3 38 0.0002787 0.007087
183 CELLULAR METABOLIC COMPOUND SALVAGE 3 38 0.0002787 0.007087
184 REGULATION OF CENTROSOME CYCLE 3 39 0.0003012 0.007618
185 NEGATIVE REGULATION OF ORGANELLE ORGANIZATION 7 387 0.0003083 0.007755
186 NEGATIVE REGULATION OF DEVELOPMENTAL PROCESS 10 801 0.0003146 0.007847
187 REGULATION OF CYCLIN DEPENDENT PROTEIN KINASE ACTIVITY 4 97 0.0003153 0.007847
188 REGULATION OF TRANSFORMING GROWTH FACTOR BETA RECEPTOR SIGNALING PATHWAY 4 99 0.0003409 0.008392
189 REGULATION OF CELLULAR RESPONSE TO TRANSFORMING GROWTH FACTOR BETA STIMULUS 4 99 0.0003409 0.008392
190 PURINE CONTAINING COMPOUND METABOLIC PROCESS 7 394 0.0003435 0.008412
191 MITOTIC SPINDLE ASSEMBLY 3 41 0.0003497 0.008431
192 MICROTUBULE CYTOSKELETON ORGANIZATION INVOLVED IN MITOSIS 3 41 0.0003497 0.008431
193 RESPONSE TO LIGHT STIMULUS 6 280 0.0003482 0.008431
194 SOMATIC DIVERSIFICATION OF IMMUNE RECEPTORS 3 42 0.0003757 0.009011
195 NEGATIVE REGULATION OF TRANSMEMBRANE RECEPTOR PROTEIN SERINE THREONINE KINASE SIGNALING PATHWAY 4 102 0.0003819 0.009114
196 MEIOTIC CELL CYCLE 5 186 0.0003992 0.009477
197 NEGATIVE REGULATION OF CATALYTIC ACTIVITY 10 829 0.0004128 0.009751
NumGOOverlapSizeP ValueAdj. P Value
1 ENZYME BINDING 28 1737 3.224e-13 2.995e-10
2 KINASE BINDING 14 606 1.055e-08 4.901e-06
3 PROTEIN COMPLEX BINDING 16 935 5.455e-08 1.296e-05
4 MISMATCHED DNA BINDING 4 12 5.579e-08 1.296e-05
5 MACROMOLECULAR COMPLEX BINDING 19 1399 9.433e-08 1.753e-05
6 DOUBLE STRANDED DNA BINDING 14 764 1.869e-07 2.894e-05
7 DAMAGED DNA BINDING 5 63 2.192e-06 0.0002909
8 SEQUENCE SPECIFIC DNA BINDING 14 1037 6.919e-06 0.0008035
9 IDENTICAL PROTEIN BINDING 15 1209 8.506e-06 0.000878
10 REGULATORY REGION NUCLEIC ACID BINDING 12 818 1.527e-05 0.00129
11 SINGLE STRANDED DNA BINDING 5 93 1.5e-05 0.00129
12 ADENYL NUCLEOTIDE BINDING 16 1514 2.982e-05 0.002308
13 RNA BINDING 16 1598 5.736e-05 0.004099
14 KINASE ACTIVITY 11 842 0.0001025 0.006348
15 RIBONUCLEOTIDE BINDING 17 1860 9.984e-05 0.006348
16 TRANSCRIPTION FACTOR ACTIVITY PROTEIN BINDING 9 588 0.0001444 0.007893
17 NF KAPPAB BINDING 3 30 0.0001367 0.007893
NumGOOverlapSizeP ValueAdj. P Value
1 CHROMOSOME 19 880 4.543e-11 2.653e-08
2 NUCLEAR CHROMOSOME 13 523 1.61e-08 4.701e-06
3 CHROMOSOMAL REGION 10 330 1.407e-07 2.74e-05
4 CONDENSED CHROMOSOME 8 195 2.821e-07 4.118e-05
5 CHROMOSOME TELOMERIC REGION 7 162 1.162e-06 0.0001357
6 MISMATCH REPAIR COMPLEX 3 14 1.274e-05 0.00124
7 CENTROSOME 9 487 3.412e-05 0.002847
8 MICROTUBULE ORGANIZING CENTER 10 623 4.007e-05 0.002925
9 NUCLEAR CHROMOSOME TELOMERIC REGION 5 132 8.075e-05 0.00524
10 TRANSFERASE COMPLEX 10 703 0.0001096 0.006165
11 NUCLEOPLASM PART 10 708 0.0001161 0.006165
12 CATALYTIC COMPLEX 12 1038 0.0001525 0.007423
13 CONDENSED NUCLEAR CHROMOSOME 4 85 0.0001899 0.008295
14 MICROTUBULE CYTOSKELETON 12 1068 0.0001989 0.008295

Over-represented Pathway

NumPathwayPathviewOverlapSizeP ValueAdj. P Value
1 Cell_cycle_hsa04110 11 124 3.175e-13 1.651e-11
2 Cellular_senescence_hsa04218 11 160 5.305e-12 1.379e-10
3 p53_signaling_pathway_hsa04115 5 68 3.21e-06 5.563e-05
4 Oocyte_meiosis_hsa04114 5 124 6e-05 0.00078
5 FoxO_signaling_pathway_hsa04068 5 132 8.075e-05 0.0008398
6 Notch_signaling_pathway_hsa04330 3 48 0.000558 0.004836
7 PI3K_Akt_signaling_pathway_hsa04151 6 352 0.001152 0.008558
8 HIF_1_signaling_pathway_hsa04066 3 100 0.004609 0.02996
9 Regulation_of_actin_cytoskeleton_hsa04810 4 208 0.005226 0.03019
10 Hippo_signaling_pathway_hsa04390 3 154 0.01497 0.07786
11 TGF_beta_signaling_pathway_hsa04350 2 84 0.03231 0.1528
12 Endocytosis_hsa04144 3 244 0.04859 0.2036
13 TNF_signaling_pathway_hsa04668 2 108 0.0509 0.2036
14 Autophagy_animal_hsa04140 2 128 0.06865 0.2541
15 MAPK_signaling_pathway_hsa04010 3 295 0.07647 0.2541
16 Apoptosis_hsa04210 2 138 0.07818 0.2541
17 mTOR_signaling_pathway_hsa04150 2 151 0.09115 0.2788
18 Rap1_signaling_pathway_hsa04015 2 206 0.1516 0.3942

lncRNA-mediated sponge

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Num lncRNA miRNAs           miRNAs count     Gene Sponge regulatory network lncRNA log2FC lncRNA pvalue Gene log2FC Gene pvalue lncRNA-gene Pearson correlation
1 TBX5-AS1 hsa-miR-103a-3p;hsa-miR-106a-5p;hsa-miR-106b-5p;hsa-miR-16-5p;hsa-miR-17-5p;hsa-miR-182-5p;hsa-miR-20a-5p;hsa-miR-21-5p;hsa-miR-25-3p;hsa-miR-590-5p 10 SMAD7 Sponge network -2.108 0 -1.033 0 0.448
2 RP11-401P9.4 hsa-miR-106a-5p;hsa-miR-106b-5p;hsa-miR-16-5p;hsa-miR-17-5p;hsa-miR-182-5p;hsa-miR-20a-5p;hsa-miR-21-3p;hsa-miR-21-5p;hsa-miR-25-3p;hsa-miR-590-5p;hsa-miR-93-5p;hsa-miR-98-5p 12 SMAD7 Sponge network -3.04 0 -1.033 0 0.437
3 RP11-389C8.2 hsa-miR-103a-3p;hsa-miR-106a-5p;hsa-miR-106b-5p;hsa-miR-17-5p;hsa-miR-182-5p;hsa-miR-20a-5p;hsa-miR-21-3p;hsa-miR-21-5p;hsa-miR-590-3p;hsa-miR-671-5p;hsa-miR-93-5p 11 SMAD7 Sponge network -2.039 0 -1.033 0 0.423
4 AC109642.1 hsa-miR-103a-3p;hsa-miR-106a-5p;hsa-miR-106b-5p;hsa-miR-16-5p;hsa-miR-17-5p;hsa-miR-182-5p;hsa-miR-20a-5p;hsa-miR-21-3p;hsa-miR-21-5p;hsa-miR-25-3p;hsa-miR-590-3p;hsa-miR-93-5p;hsa-miR-98-5p 13 SMAD7 Sponge network -2.791 0 -1.033 0 0.421
5 LINC00702 hsa-miR-103a-3p;hsa-miR-106a-5p;hsa-miR-106b-5p;hsa-miR-16-5p;hsa-miR-17-5p;hsa-miR-182-5p;hsa-miR-20a-5p;hsa-miR-21-3p;hsa-miR-21-5p;hsa-miR-25-3p;hsa-miR-590-3p;hsa-miR-590-5p;hsa-miR-671-5p;hsa-miR-93-5p 14 SMAD7 Sponge network -2.856 0 -1.033 0 0.388
6 RP11-456K23.1 hsa-miR-106a-5p;hsa-miR-106b-5p;hsa-miR-16-5p;hsa-miR-17-5p;hsa-miR-182-5p;hsa-miR-20a-5p;hsa-miR-21-3p;hsa-miR-21-5p;hsa-miR-25-3p;hsa-miR-590-3p;hsa-miR-590-5p;hsa-miR-93-5p 12 SMAD7 Sponge network -1.488 0 -1.033 0 0.383
7 RP11-1024P17.1 hsa-miR-106a-5p;hsa-miR-106b-5p;hsa-miR-16-5p;hsa-miR-17-5p;hsa-miR-182-5p;hsa-miR-20a-5p;hsa-miR-21-3p;hsa-miR-21-5p;hsa-miR-25-3p;hsa-miR-590-3p 10 SMAD7 Sponge network -2.062 0 -1.033 0 0.371
8 LINC00968 hsa-miR-106a-5p;hsa-miR-106b-5p;hsa-miR-16-5p;hsa-miR-17-5p;hsa-miR-182-5p;hsa-miR-20a-5p;hsa-miR-21-5p;hsa-miR-25-3p;hsa-miR-590-3p;hsa-miR-590-5p;hsa-miR-671-5p;hsa-miR-93-5p 12 SMAD7 Sponge network -4.19 0 -1.033 0 0.36
9 MAGI2-AS3 hsa-miR-103a-3p;hsa-miR-106a-5p;hsa-miR-106b-5p;hsa-miR-16-5p;hsa-miR-17-5p;hsa-miR-182-5p;hsa-miR-20a-5p;hsa-miR-21-3p;hsa-miR-21-5p;hsa-miR-25-3p;hsa-miR-590-3p;hsa-miR-671-5p;hsa-miR-93-5p 13 SMAD7 Sponge network -1.892 0 -1.033 0 0.353
10 MIR497HG hsa-miR-103a-3p;hsa-miR-106a-5p;hsa-miR-106b-5p;hsa-miR-16-5p;hsa-miR-17-5p;hsa-miR-182-5p;hsa-miR-20a-5p;hsa-miR-21-3p;hsa-miR-21-5p;hsa-miR-25-3p;hsa-miR-590-5p;hsa-miR-671-5p;hsa-miR-93-5p 13 SMAD7 Sponge network -2.142 0 -1.033 0 0.352
11 CTD-2013N24.2 hsa-miR-106a-5p;hsa-miR-106b-5p;hsa-miR-16-5p;hsa-miR-17-5p;hsa-miR-182-5p;hsa-miR-20a-5p;hsa-miR-21-5p;hsa-miR-25-3p;hsa-miR-590-3p;hsa-miR-93-5p 10 SMAD7 Sponge network -1.745 0 -1.033 0 0.336
12 FENDRR hsa-miR-106a-5p;hsa-miR-106b-5p;hsa-miR-16-5p;hsa-miR-17-5p;hsa-miR-182-5p;hsa-miR-20a-5p;hsa-miR-21-3p;hsa-miR-21-5p;hsa-miR-25-3p;hsa-miR-590-3p;hsa-miR-671-5p;hsa-miR-93-5p;hsa-miR-98-5p 13 SMAD7 Sponge network -4.222 0 -1.033 0 0.334
13 DNM3OS hsa-miR-106a-5p;hsa-miR-106b-5p;hsa-miR-16-5p;hsa-miR-17-5p;hsa-miR-182-5p;hsa-miR-20a-5p;hsa-miR-25-3p;hsa-miR-590-3p;hsa-miR-590-5p;hsa-miR-93-5p 10 SMAD7 Sponge network 0.053 0.85755 -1.033 0 0.33
14 LL22NC03-86G7.1 hsa-miR-106a-5p;hsa-miR-106b-5p;hsa-miR-16-5p;hsa-miR-17-5p;hsa-miR-182-5p;hsa-miR-21-3p;hsa-miR-21-5p;hsa-miR-25-3p;hsa-miR-590-3p;hsa-miR-590-5p;hsa-miR-93-5p;hsa-miR-98-5p 12 SMAD7 Sponge network -1.177 3.0E-5 -1.033 0 0.32
15 BAIAP2-AS1 hsa-miR-103a-3p;hsa-miR-106a-5p;hsa-miR-106b-5p;hsa-miR-16-5p;hsa-miR-17-5p;hsa-miR-20a-5p;hsa-miR-25-3p;hsa-miR-590-3p;hsa-miR-671-5p;hsa-miR-93-5p 10 SMAD7 Sponge network -0.182 0.51705 -1.033 0 0.301
16 LINC00261 hsa-miR-106a-5p;hsa-miR-106b-5p;hsa-miR-17-5p;hsa-miR-182-5p;hsa-miR-20a-5p;hsa-miR-21-3p;hsa-miR-21-5p;hsa-miR-25-3p;hsa-miR-590-3p;hsa-miR-590-5p;hsa-miR-671-5p 11 SMAD7 Sponge network -2.566 0.00025 -1.033 0 0.283
17 AC007743.1 hsa-miR-106a-5p;hsa-miR-106b-5p;hsa-miR-16-5p;hsa-miR-17-5p;hsa-miR-182-5p;hsa-miR-20a-5p;hsa-miR-21-5p;hsa-miR-590-5p;hsa-miR-671-5p;hsa-miR-93-5p 10 SMAD7 Sponge network -2.595 0 -1.033 0 0.268
18 RP11-536K7.3 hsa-miR-103a-3p;hsa-miR-106a-5p;hsa-miR-106b-5p;hsa-miR-16-5p;hsa-miR-17-5p;hsa-miR-182-5p;hsa-miR-20a-5p;hsa-miR-21-3p;hsa-miR-21-5p;hsa-miR-25-3p;hsa-miR-93-5p 11 SMAD7 Sponge network -1.239 5.0E-5 -1.033 0 0.266
19 AC079630.4 hsa-miR-106a-5p;hsa-miR-106b-5p;hsa-miR-17-5p;hsa-miR-182-5p;hsa-miR-20a-5p;hsa-miR-21-5p;hsa-miR-25-3p;hsa-miR-590-3p;hsa-miR-671-5p;hsa-miR-93-5p 10 SMAD7 Sponge network -3.758 0 -1.033 0 0.259
20 RP11-354E11.2 hsa-miR-106a-5p;hsa-miR-106b-5p;hsa-miR-16-5p;hsa-miR-17-5p;hsa-miR-182-5p;hsa-miR-20a-5p;hsa-miR-21-5p;hsa-miR-25-3p;hsa-miR-590-3p;hsa-miR-671-5p 10 SMAD7 Sponge network -2.138 0 -1.033 0 0.258

Quest ID: 7b4befc2d713bcc322849ad1d7138b6d