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This regulatory network was inferred from the input dataset. The miRNAs and mRNAs are presented as round and rectangle nodes respectively. The numerical value popped up upon mouse over the gene node is the log2 transformed fold-change of the gene expression between the two groups. All of the nodes are clickable, and the detailed information of the miRNAs/mRNAs and related cancer pathway will be displayed in another window. The edges between nodes are supported by both interactions (predicted or experimentally verified) and correlations learnt from cancer dataset. The numerical value popped up upon mouse over the edge is the correlation beat value (effect size) between the two nodes. The experimental evidences of the edges reported in previous cancer studies are highlighted by red/orange color. All of these information can be accessed by the "mouse-over" action. This network shows a full map of the miRNA-mRNA regulation of the input gene list(s), and the hub miRNAs (with the high network degree/betweenness centrality) would be the potential cancer drivers or tumor suppressors. The full result table can be accessed in the "Regulations" tab.

"miRNACancerMAP" is also a network visualization tool for users to draw their regulatory network by personal customization. Users can set the complexity of the network by limiting the number of nodes or edges. And the color of the nodes can be defined by different categories of the mRNAs and miRNAs, such as Gene-Ontology, pathway, and expression status. Users can also select to use network degree or network betweenness centrality to define the node size. And edges can be black or colored by the correlation. Purple edge means negative correlation (mostly found between miRNA and mRNA), and blue edge means positive correlation (found in PPI or miRNA-miRNA sponge effect). We can also add the protein-protein interactions (PPI) into the network. This result will show the cluster of genes regulated by some specific miRNAs. Additionally, miRNA-miRNA edges can be added by the "miRNA sponge" button, presenting some clusters of miRNAs that have the interactions via sponge effect.

miRNA-gene regulations

(Download full result)

Num microRNA           Gene miRNA log2FC miRNA pvalue Gene log2FC Gene pvalue Interaction Correlation beta Correlation P-value PMID Reported in cancer studies
1 hsa-miR-139-3p SOX4 -4 0 1.65 0 miRNATAP -0.22 0 NA
2 hsa-miR-140-5p SOX4 0.67 0.00034 1.65 0 PITA; miRanda; miRNATAP -0.14 0.00649 27353653 MicroRNA 140 Inhibits Cell Proliferation in Gastric Cancer Cell Line HGC 27 by Suppressing SOX4; SOX4 a predicted target of miR-140 was mutated to verify its regulation by miR-140 and was overexpressed to analyze its function in cell proliferation; miR-140 suppressed SOX4 expression via binding to the 3' untranslated region while the mutant SOX4 could not be regulated; CONCLUSIONS These findings suggest that miR-140 directly inhibits SOX4 which might be one of its mechanisms in suppressing gastric cancer cell proliferation
3 hsa-miR-145-5p SOX4 -1.35 0 1.65 0 mirMAP -0.15 1.0E-5 NA
4 hsa-miR-146b-3p SOX4 -0.81 0.00087 1.65 0 PITA -0.29 0 NA
5 hsa-miR-30a-3p SOX4 -2.54 0 1.65 0 mirMAP -0.24 0 25572678 Association of SOX4 regulated by tumor suppressor miR 30a with poor prognosis in low grade chondrosarcoma; In an attempt of characterizing SOX4 overexpression mechanism we identified miR-30a as a tumor suppressor that directly targets SOX4 in chondrosarcoma cells; Clinically miR-30a expression was negatively correlated with SOX4 expression in chondrosarcoma cases; In all we identified that SOX4 was oncogenic in chondrosarcoma and negatively regulated by miR-30a in vitro
6 hsa-miR-30a-5p SOX4 -0.92 0.00076 1.65 0 miRNATAP -0.26 0 25572678 Association of SOX4 regulated by tumor suppressor miR 30a with poor prognosis in low grade chondrosarcoma; In an attempt of characterizing SOX4 overexpression mechanism we identified miR-30a as a tumor suppressor that directly targets SOX4 in chondrosarcoma cells; Clinically miR-30a expression was negatively correlated with SOX4 expression in chondrosarcoma cases; In all we identified that SOX4 was oncogenic in chondrosarcoma and negatively regulated by miR-30a in vitro
7 hsa-miR-30c-5p SOX4 -0.33 0.1236 1.65 0 miRNAWalker2 validate; miRNATAP -0.21 0 NA
8 hsa-miR-30d-5p SOX4 -0.92 4.0E-5 1.65 0 miRNATAP -0.12 0.00262 NA
9 hsa-miR-30e-3p SOX4 -0.1 0.52624 1.65 0 mirMAP -0.17 0.00193 NA
10 hsa-miR-320a SOX4 -0.96 0 1.65 0 PITA; miRanda; miRNATAP -0.16 0.00258 NA
11 hsa-miR-342-5p SOX4 -0.38 0.0897 1.65 0 MirTarget; PITA; miRNATAP -0.15 0.00036 NA
NumGOOverlapSizeP ValueAdj. P Value
1 CELLULAR RESPONSE TO ORGANIC SUBSTANCE 23 1848 1.763e-17 8.203e-14
2 IMMUNE SYSTEM DEVELOPMENT 15 582 2.725e-15 6.339e-12
3 POSITIVE REGULATION OF BIOSYNTHETIC PROCESS 21 1805 5.054e-15 7.839e-12
4 LEUKOCYTE DIFFERENTIATION 12 292 1.303e-14 1.516e-11
5 POSITIVE REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 17 1004 1.983e-14 1.846e-11
6 POSITIVE REGULATION OF GENE EXPRESSION 20 1733 4.187e-14 3.247e-11
7 CELL ACTIVATION 14 568 5.584e-14 3.582e-11
8 RESPONSE TO LIPID 16 888 6.158e-14 3.582e-11
9 REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 20 1784 7.268e-14 3.758e-11
10 IMMUNE SYSTEM PROCESS 20 1984 5.428e-13 2.526e-10
11 LEUKOCYTE ACTIVATION 12 414 8.208e-13 3.234e-10
12 REGULATION OF CELL PROLIFERATION 18 1496 8.34e-13 3.234e-10
13 POSITIVE REGULATION OF CELL PROLIFERATION 14 814 7.304e-12 2.614e-09
14 MYELOID CELL DIFFERENTIATION 9 189 1.154e-11 3.837e-09
15 RESPONSE TO OXYGEN CONTAINING COMPOUND 16 1381 5.12e-11 1.588e-08
16 POSITIVE REGULATION OF RESPONSE TO STIMULUS 18 1929 6.069e-11 1.765e-08
17 CELLULAR RESPONSE TO LIPID 11 457 6.587e-11 1.803e-08
18 LYMPHOCYTE ACTIVATION 10 342 8.663e-11 2.239e-08
19 CELLULAR RESPONSE TO OXYGEN CONTAINING COMPOUND 13 799 1.031e-10 2.351e-08
20 RESPONSE TO ENDOGENOUS STIMULUS 16 1450 1.061e-10 2.351e-08
21 REGULATION OF PROTEIN MODIFICATION PROCESS 17 1710 1.052e-10 2.351e-08
22 REGULATION OF CELL DEATH 16 1472 1.328e-10 2.809e-08
23 MYELOID LEUKOCYTE DIFFERENTIATION 7 96 1.434e-10 2.902e-08
24 REGULATION OF CELL DIFFERENTIATION 16 1492 1.624e-10 3.148e-08
25 POSITIVE REGULATION OF CATALYTIC ACTIVITY 16 1518 2.099e-10 3.899e-08
26 POSITIVE REGULATION OF MOLECULAR FUNCTION 17 1791 2.179e-10 3.899e-08
27 RESPONSE TO HORMONE 13 893 4.057e-10 6.991e-08
28 POSITIVE REGULATION OF MULTICELLULAR ORGANISMAL PROCESS 15 1395 7.622e-10 1.267e-07
29 REGULATION OF MULTICELLULAR ORGANISMAL DEVELOPMENT 16 1672 8.759e-10 1.359e-07
30 POSITIVE REGULATION OF CARDIAC MUSCLE TISSUE DEVELOPMENT 5 29 8.733e-10 1.359e-07
31 LYMPHOCYTE DIFFERENTIATION 8 209 1.055e-09 1.583e-07
32 TUBE MORPHOGENESIS 9 323 1.353e-09 1.968e-07
33 DENDRITIC CELL DIFFERENTIATION 5 33 1.738e-09 2.367e-07
34 CELLULAR RESPONSE TO ENDOGENOUS STIMULUS 13 1008 1.781e-09 2.367e-07
35 LYMPHOID PROGENITOR CELL DIFFERENTIATION 4 11 1.767e-09 2.367e-07
36 POSITIVE REGULATION OF PROTEIN METABOLIC PROCESS 15 1492 1.933e-09 2.499e-07
37 POSITIVE REGULATION OF CELL COMMUNICATION 15 1532 2.784e-09 3.409e-07
38 MOVEMENT OF CELL OR SUBCELLULAR COMPONENT 14 1275 2.714e-09 3.409e-07
39 REGULATION OF PHOSPHATIDYLINOSITOL 3 KINASE ACTIVITY 5 40 4.779e-09 5.702e-07
40 HOMEOSTATIC PROCESS 14 1337 5.009e-09 5.827e-07
41 POSITIVE REGULATION OF TRANSCRIPTION REGULATORY REGION DNA BINDING 4 14 5.341e-09 6.061e-07
42 REGULATION OF CELL CELL ADHESION 9 380 5.598e-09 6.202e-07
43 LOCOMOTION 13 1114 5.967e-09 6.457e-07
44 POSITIVE REGULATION OF PROTEIN MODIFICATION PROCESS 13 1135 7.471e-09 7.9e-07
45 TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 11 724 8.355e-09 8.639e-07
46 MORPHOGENESIS OF AN EPITHELIUM 9 400 8.739e-09 8.744e-07
47 TUBE DEVELOPMENT 10 552 8.832e-09 8.744e-07
48 REGULATION OF CELL PROJECTION ORGANIZATION 10 558 9.789e-09 9.296e-07
49 HOMEOSTASIS OF NUMBER OF CELLS 7 175 9.745e-09 9.296e-07
50 EPITHELIUM DEVELOPMENT 12 945 1.086e-08 9.717e-07
51 REGULATION OF CYTOKINE PRODUCTION 10 563 1.066e-08 9.717e-07
52 NEGATIVE REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 11 740 1.048e-08 9.717e-07
53 REGULATION OF LIPID METABOLIC PROCESS 8 282 1.11e-08 9.742e-07
54 REGULATION OF CARDIAC MUSCLE TISSUE DEVELOPMENT 5 48 1.233e-08 1.043e-06
55 REGULATION OF LIPID KINASE ACTIVITY 5 48 1.233e-08 1.043e-06
56 PEPTIDYL TYROSINE MODIFICATION 7 186 1.486e-08 1.235e-06
57 REGULATION OF CELLULAR COMPONENT MOVEMENT 11 771 1.6e-08 1.306e-06
58 REGULATION OF RESPONSE TO STRESS 14 1468 1.659e-08 1.331e-06
59 REGULATION OF ENDOTHELIAL CELL MIGRATION 6 114 2.412e-08 1.902e-06
60 POSITIVE REGULATION OF TRANSFERASE ACTIVITY 10 616 2.499e-08 1.927e-06
61 REGULATION OF ANATOMICAL STRUCTURE MORPHOGENESIS 12 1021 2.567e-08 1.927e-06
62 TISSUE DEVELOPMENT 14 1518 2.541e-08 1.927e-06
63 POSITIVE REGULATION OF MUSCLE TISSUE DEVELOPMENT 5 56 2.725e-08 2.013e-06
64 RESPONSE TO EXTERNAL STIMULUS 15 1821 2.932e-08 2.132e-06
65 REGULATION OF CELL ADHESION 10 629 3.043e-08 2.146e-06
66 RESPONSE TO MOLECULE OF BACTERIAL ORIGIN 8 321 3.036e-08 2.146e-06
67 POSITIVE REGULATION OF CELL DIFFERENTIATION 11 823 3.13e-08 2.174e-06
68 REGULATION OF PROTEIN KINASE B SIGNALING 6 121 3.449e-08 2.36e-06
69 CELL MOTILITY 11 835 3.63e-08 2.413e-06
70 LOCALIZATION OF CELL 11 835 3.63e-08 2.413e-06
71 INTRACELLULAR SIGNAL TRANSDUCTION 14 1572 3.956e-08 2.593e-06
72 REGULATION OF PHOSPHOLIPID METABOLIC PROCESS 5 61 4.22e-08 2.727e-06
73 POSITIVE REGULATION OF KINASE ACTIVITY 9 482 4.362e-08 2.78e-06
74 REGULATION OF PROTEIN ACETYLATION 5 64 5.39e-08 3.389e-06
75 CELL PROLIFERATION 10 672 5.668e-08 3.47e-06
76 NEGATIVE REGULATION OF CELL DEATH 11 872 5.653e-08 3.47e-06
77 IMMUNE RESPONSE 12 1100 5.845e-08 3.532e-06
78 POSITIVE REGULATION OF ENDOTHELIAL CELL MIGRATION 5 67 6.805e-08 4.059e-06
79 EMBRYO DEVELOPMENT 11 894 7.285e-08 4.291e-06
80 REGULATION OF INTRACELLULAR SIGNAL TRANSDUCTION 14 1656 7.623e-08 4.434e-06
81 POSITIVE REGULATION OF HYDROLASE ACTIVITY 11 905 8.249e-08 4.739e-06
82 POSITIVE REGULATION OF DEVELOPMENTAL PROCESS 12 1142 8.819e-08 5.004e-06
83 REGULATION OF IMMUNE SYSTEM PROCESS 13 1403 9.278e-08 5.201e-06
84 RESPONSE TO ORGANIC CYCLIC COMPOUND 11 917 9.43e-08 5.223e-06
85 RESPONSE TO CYTOKINE 10 714 9.993e-08 5.47e-06
86 TISSUE MORPHOGENESIS 9 533 1.029e-07 5.505e-06
87 REGULATION OF RESPONSE TO EXTERNAL STIMULUS 11 926 1.041e-07 5.505e-06
88 POSITIVE REGULATION OF CELL ADHESION 8 376 1.027e-07 5.505e-06
89 REGULATION OF ORGANELLE ORGANIZATION 12 1178 1.238e-07 6.473e-06
90 PROTEIN PHOSPHORYLATION 11 944 1.265e-07 6.541e-06
91 ANATOMICAL STRUCTURE FORMATION INVOLVED IN MORPHOGENESIS 11 957 1.453e-07 7.428e-06
92 NEGATIVE REGULATION OF LOCOMOTION 7 263 1.596e-07 8.07e-06
93 REGULATION OF DEFENSE RESPONSE 10 759 1.765e-07 8.829e-06
94 POSITIVE REGULATION OF LIPID KINASE ACTIVITY 4 32 1.88e-07 9.299e-06
95 REGULATION OF NEURON PROJECTION DEVELOPMENT 8 408 1.919e-07 9.299e-06
96 NEGATIVE REGULATION OF MULTICELLULAR ORGANISMAL PROCESS 11 983 1.904e-07 9.299e-06
97 PHOSPHORYLATION 12 1228 1.947e-07 9.339e-06
98 CELLULAR RESPONSE TO BIOTIC STIMULUS 6 163 2.032e-07 9.647e-06
99 REGULATION OF KINASE ACTIVITY 10 776 2.167e-07 1.018e-05
100 REGULATION OF EPITHELIAL CELL MIGRATION 6 166 2.263e-07 1.053e-05
101 RESPONSE TO FLUID SHEAR STRESS 4 34 2.42e-07 1.093e-05
102 POSITIVE REGULATION OF LOCOMOTION 8 420 2.393e-07 1.093e-05
103 POSITIVE REGULATION OF REACTIVE OXYGEN SPECIES METABOLIC PROCESS 5 86 2.402e-07 1.093e-05
104 REGULATION OF EPITHELIAL CELL PROLIFERATION 7 285 2.75e-07 1.23e-05
105 POSITIVE REGULATION OF PROTEIN SERINE THREONINE KINASE ACTIVITY 7 289 3.022e-07 1.339e-05
106 REGULATION OF TRANSCRIPTION REGULATORY REGION DNA BINDING 4 36 3.066e-07 1.346e-05
107 POSITIVE REGULATION OF PHOSPHATE METABOLIC PROCESS 11 1036 3.226e-07 1.39e-05
108 POSITIVE REGULATION OF PHOSPHORUS METABOLIC PROCESS 11 1036 3.226e-07 1.39e-05
109 POSITIVE REGULATION OF RESPONSE TO EXTERNAL STIMULUS 7 296 3.552e-07 1.516e-05
110 REGULATION OF HOMEOSTATIC PROCESS 8 447 3.841e-07 1.625e-05
111 REGULATION OF CELL DEVELOPMENT 10 836 4.308e-07 1.806e-05
112 REGULATION OF HYDROLASE ACTIVITY 12 1327 4.501e-07 1.87e-05
113 HEMATOPOIETIC PROGENITOR CELL DIFFERENTIATION 5 98 4.621e-07 1.886e-05
114 MYELOID LEUKOCYTE ACTIVATION 5 98 4.621e-07 1.886e-05
115 REGULATION OF PHOSPHORUS METABOLIC PROCESS 13 1618 4.872e-07 1.971e-05
116 POSITIVE REGULATION OF CELL ACTIVATION 7 311 4.955e-07 1.987e-05
117 CELLULAR RESPONSE TO ORGANIC CYCLIC COMPOUND 8 465 5.179e-07 2.06e-05
118 NEGATIVE REGULATION OF FAT CELL DIFFERENTIATION 4 41 5.242e-07 2.066e-05
119 REGULATION OF HEMOPOIESIS 7 314 5.285e-07 2.066e-05
120 WOUND HEALING 8 470 5.615e-07 2.177e-05
121 REGULATION OF MUSCLE TISSUE DEVELOPMENT 5 103 5.923e-07 2.205e-05
122 POSITIVE REGULATION OF DNA BINDING 4 42 5.788e-07 2.205e-05
123 POSITIVE REGULATION OF PHOSPHOLIPID METABOLIC PROCESS 4 42 5.788e-07 2.205e-05
124 POSITIVE REGULATION OF EPITHELIAL CELL MIGRATION 5 103 5.923e-07 2.205e-05
125 REGULATION OF MUSCLE ORGAN DEVELOPMENT 5 103 5.923e-07 2.205e-05
126 POSITIVE REGULATION OF IMMUNE SYSTEM PROCESS 10 867 6.016e-07 2.222e-05
127 RESPONSE TO GROWTH FACTOR 8 475 6.081e-07 2.228e-05
128 REGULATION OF MAPK CASCADE 9 660 6.242e-07 2.269e-05
129 CELL FATE DETERMINATION 4 43 6.374e-07 2.299e-05
130 POSITIVE REGULATION OF INTRACELLULAR SIGNAL TRANSDUCTION 10 876 6.612e-07 2.367e-05
131 REGULATION OF CELL ACTIVATION 8 484 7.006e-07 2.488e-05
132 REGULATION OF SEQUESTERING OF CALCIUM ION 5 107 7.16e-07 2.524e-05
133 RESPONSE TO BIOTIC STIMULUS 10 886 7.335e-07 2.566e-05
134 REGULATION OF INTERLEUKIN 8 BIOSYNTHETIC PROCESS 3 12 8.105e-07 2.815e-05
135 POSITIVE REGULATION OF MAP KINASE ACTIVITY 6 207 8.277e-07 2.839e-05
136 EPITHELIAL CELL DIFFERENTIATION 8 495 8.297e-07 2.839e-05
137 RESPONSE TO STEROID HORMONE 8 497 8.553e-07 2.905e-05
138 POSITIVE REGULATION OF CELLULAR COMPONENT ORGANIZATION 11 1152 9.276e-07 3.105e-05
139 NEGATIVE REGULATION OF CYTOKINE PRODUCTION 6 211 9.256e-07 3.105e-05
140 REGULATION OF SECRETION 9 699 1.007e-06 3.347e-05
141 POSITIVE REGULATION OF CARDIAC MUSCLE CELL DIFFERENTIATION 3 13 1.053e-06 3.473e-05
142 REGULATION OF BLOOD VESSEL ENDOTHELIAL CELL MIGRATION 4 51 1.279e-06 4.192e-05
143 REGULATION OF TRANSFERASE ACTIVITY 10 946 1.332e-06 4.32e-05
144 RESPONSE TO BACTERIUM 8 528 1.346e-06 4.32e-05
145 RESPONSE TO LAMINAR FLUID SHEAR STRESS 3 14 1.338e-06 4.32e-05
146 T CELL DIFFERENTIATION 5 123 1.429e-06 4.555e-05
147 NEGATIVE REGULATION OF GENE EXPRESSION 12 1493 1.583e-06 4.944e-05
148 EMBRYONIC MORPHOGENESIS 8 539 1.571e-06 4.944e-05
149 POSITIVE REGULATION OF CYTOKINE PRODUCTION 7 370 1.583e-06 4.944e-05
150 POSITIVE REGULATION OF BINDING 5 127 1.674e-06 5.193e-05
151 POSITIVE REGULATION OF LIPID METABOLIC PROCESS 5 128 1.74e-06 5.362e-05
152 REGULATION OF NERVOUS SYSTEM DEVELOPMENT 9 750 1.804e-06 5.524e-05
153 CELLULAR RESPONSE TO HORMONE STIMULUS 8 552 1.876e-06 5.669e-05
154 REGULATION OF ERK1 AND ERK2 CASCADE 6 238 1.865e-06 5.669e-05
155 REGULATION OF NEURON DIFFERENTIATION 8 554 1.928e-06 5.786e-05
156 REGULATION OF CYTOKINE PRODUCTION INVOLVED IN IMMUNE RESPONSE 4 57 2.008e-06 5.99e-05
157 POSITIVE REGULATION OF CELL CELL ADHESION 6 243 2.103e-06 6.234e-05
158 RESPONSE TO WOUNDING 8 563 2.173e-06 6.4e-05
159 GLAND DEVELOPMENT 7 395 2.443e-06 7.149e-05
160 REGULATION OF CELLULAR LOCALIZATION 11 1277 2.551e-06 7.418e-05
161 CARDIOVASCULAR SYSTEM DEVELOPMENT 9 788 2.71e-06 7.784e-05
162 CIRCULATORY SYSTEM DEVELOPMENT 9 788 2.71e-06 7.784e-05
163 LEUKOCYTE CELL CELL ADHESION 6 255 2.78e-06 7.935e-05
164 SIGNAL TRANSDUCTION BY PROTEIN PHOSPHORYLATION 7 404 2.835e-06 8.044e-05
165 REGULATION OF RESPONSE TO WOUNDING 7 413 3.279e-06 9.246e-05
166 REGULATION OF REACTIVE OXYGEN SPECIES BIOSYNTHETIC PROCESS 4 65 3.412e-06 9.563e-05
167 REGULATION OF CARDIAC MUSCLE CELL DIFFERENTIATION 3 19 3.543e-06 9.813e-05
168 POSITIVE REGULATION OF CARDIAC MUSCLE CELL PROLIFERATION 3 19 3.543e-06 9.813e-05
169 SOMATIC STEM CELL POPULATION MAINTENANCE 4 66 3.628e-06 9.988e-05
170 CELLULAR RESPONSE TO CYTOKINE STIMULUS 8 606 3.75e-06 0.0001026
171 REGULATION OF REACTIVE OXYGEN SPECIES METABOLIC PROCESS 5 152 4.05e-06 0.0001096
172 REGULATION OF CHROMATIN ORGANIZATION 5 152 4.05e-06 0.0001096
173 MYELOID DENDRITIC CELL DIFFERENTIATION 3 20 4.164e-06 0.000112
174 POSITIVE REGULATION OF EPITHELIAL CELL PROLIFERATION 5 154 4.318e-06 0.0001155
175 ORGAN MORPHOGENESIS 9 841 4.615e-06 0.000122
176 POSITIVE REGULATION OF DEVELOPMENTAL GROWTH 5 156 4.599e-06 0.000122
177 PHOSPHATE CONTAINING COMPOUND METABOLIC PROCESS 13 1977 4.724e-06 0.0001235
178 NEGATIVE REGULATION OF RESPONSE TO STIMULUS 11 1360 4.7e-06 0.0001235
179 REGULATION OF GROWTH 8 633 5.172e-06 0.0001344
180 REGULATION OF DEVELOPMENTAL GROWTH 6 289 5.71e-06 0.0001476
181 CYTOKINE MEDIATED SIGNALING PATHWAY 7 452 5.932e-06 0.0001525
182 NEUROGENESIS 11 1402 6.301e-06 0.0001602
183 REGULATION OF INFLAMMATORY RESPONSE 6 294 6.299e-06 0.0001602
184 GLIAL CELL DEVELOPMENT 4 76 6.386e-06 0.0001615
185 SINGLE ORGANISM CELL ADHESION 7 459 6.56e-06 0.000165
186 TAXIS 7 464 7.041e-06 0.0001761
187 NEGATIVE REGULATION OF BLOOD VESSEL ENDOTHELIAL CELL MIGRATION 3 24 7.36e-06 0.0001831
188 CELL DEVELOPMENT 11 1426 7.416e-06 0.0001835
189 POSITIVE REGULATION OF MAPK CASCADE 7 470 7.657e-06 0.0001856
190 VASCULATURE DEVELOPMENT 7 469 7.551e-06 0.0001856
191 REGULATION OF PROTEIN SERINE THREONINE KINASE ACTIVITY 7 470 7.657e-06 0.0001856
192 EXTRACELLULAR STRUCTURE ORGANIZATION 6 304 7.626e-06 0.0001856
193 POSITIVE REGULATION OF PROTEIN KINASE B SIGNALING 4 81 8.235e-06 0.0001985
194 POSITIVE REGULATION OF BLOOD VESSEL ENDOTHELIAL CELL MIGRATION 3 25 8.355e-06 0.0002004
195 REGULATION OF CHEMOTAXIS 5 180 9.235e-06 0.0002204
196 MYELOID DENDRITIC CELL ACTIVATION 3 26 9.434e-06 0.000224
197 REGULATION OF MYELOID CELL DIFFERENTIATION 5 183 1.001e-05 0.0002358
198 REGULATION OF MAP KINASE ACTIVITY 6 319 1.003e-05 0.0002358
199 POSITIVE REGULATION OF B CELL ACTIVATION 4 86 1.045e-05 0.0002444
200 POSITIVE REGULATION OF HEART GROWTH 3 27 1.06e-05 0.0002454
201 INFLAMMATORY RESPONSE TO ANTIGENIC STIMULUS 3 27 1.06e-05 0.0002454
202 LEUKOCYTE PROLIFERATION 4 88 1.145e-05 0.0002625
203 POSITIVE REGULATION OF PEPTIDYL SERINE PHOSPHORYLATION 4 88 1.145e-05 0.0002625
204 CELL FATE COMMITMENT INVOLVED IN FORMATION OF PRIMARY GERM LAYER 3 28 1.186e-05 0.0002705
205 REGULATION OF BODY FLUID LEVELS 7 506 1.237e-05 0.0002808
206 REGULATION OF CARDIAC MUSCLE CELL PROLIFERATION 3 29 1.322e-05 0.0002985
207 NEGATIVE REGULATION OF NITROGEN COMPOUND METABOLIC PROCESS 11 1517 1.338e-05 0.0003007
208 POSITIVE REGULATION OF ESTABLISHMENT OF PROTEIN LOCALIZATION 7 514 1.37e-05 0.0003064
209 REGULATION OF DNA BINDING 4 93 1.426e-05 0.0003168
210 POSITIVE REGULATION OF PROTEIN COMPLEX ASSEMBLY 5 197 1.43e-05 0.0003168
211 REGULATION OF CYTOKINE BIOSYNTHETIC PROCESS 4 94 1.488e-05 0.000328
212 DIVALENT INORGANIC CATION HOMEOSTASIS 6 343 1.515e-05 0.0003324
213 CANONICAL WNT SIGNALING PATHWAY 4 95 1.551e-05 0.0003389
214 REGULATION OF ION HOMEOSTASIS 5 201 1.575e-05 0.0003425
215 MACROPHAGE ACTIVATION 3 31 1.622e-05 0.0003495
216 LIPOPOLYSACCHARIDE MEDIATED SIGNALING PATHWAY 3 31 1.622e-05 0.0003495
217 REGULATION OF INTERFERON GAMMA PRODUCTION 4 97 1.684e-05 0.0003612
218 CELL DEATH 9 1001 1.878e-05 0.0004008
219 REGULATION OF PRODUCTION OF MOLECULAR MEDIATOR OF IMMUNE RESPONSE 4 101 1.976e-05 0.0004199
220 HEART MORPHOGENESIS 5 212 2.036e-05 0.0004306
221 REGULATION OF CYSTEINE TYPE ENDOPEPTIDASE ACTIVITY 5 213 2.083e-05 0.0004385
222 REGULATION OF CELLULAR COMPONENT BIOGENESIS 8 767 2.093e-05 0.0004386
223 POSITIVE REGULATION OF DEFENSE RESPONSE 6 364 2.118e-05 0.000442
224 HEART VALVE DEVELOPMENT 3 34 2.153e-05 0.0004451
225 REGULATION OF SEQUENCE SPECIFIC DNA BINDING TRANSCRIPTION FACTOR ACTIVITY 6 365 2.151e-05 0.0004451
226 EMBRYO DEVELOPMENT ENDING IN BIRTH OR EGG HATCHING 7 554 2.22e-05 0.0004532
227 CARDIAC CHAMBER MORPHOGENESIS 4 104 2.218e-05 0.0004532
228 POSITIVE REGULATION OF PROTEIN IMPORT 4 104 2.218e-05 0.0004532
229 POSITIVE REGULATION OF SECRETION 6 370 2.322e-05 0.0004719
230 REGULATION OF FAT CELL DIFFERENTIATION 4 106 2.391e-05 0.0004819
231 BIOLOGICAL ADHESION 9 1032 2.393e-05 0.0004819
232 REGULATION OF NUCLEOCYTOPLASMIC TRANSPORT 5 220 2.433e-05 0.0004879
233 POSITIVE REGULATION OF IMMUNE RESPONSE 7 563 2.462e-05 0.0004917
234 REGULATION OF PROTEIN COMPLEX ASSEMBLY 6 375 2.505e-05 0.000498
235 POSITIVE REGULATION OF PROTEIN ACETYLATION 3 36 2.563e-05 0.0005074
236 POSITIVE REGULATION OF B CELL PROLIFERATION 3 37 2.786e-05 0.0005493
237 CELL FATE COMMITMENT 5 227 2.827e-05 0.000555
238 NEGATIVE REGULATION OF DEVELOPMENTAL PROCESS 8 801 2.857e-05 0.0005585
239 CYTOKINE SECRETION 3 38 3.021e-05 0.0005858
240 POSITIVE REGULATION OF ORGAN GROWTH 3 38 3.021e-05 0.0005858
241 REGULATION OF PROTEIN SECRETION 6 389 3.076e-05 0.0005915
242 POSITIVE REGULATION OF INFLAMMATORY RESPONSE 4 113 3.075e-05 0.0005915
243 REGULATION OF VASCULATURE DEVELOPMENT 5 233 3.202e-05 0.0006132
244 NEGATIVE REGULATION OF ENDOTHELIAL CELL MIGRATION 3 39 3.27e-05 0.0006235
245 POSITIVE REGULATION OF GROWTH 5 238 3.544e-05 0.0006731
246 REGULATION OF PEPTIDYL SERINE PHOSPHORYLATION 4 118 3.644e-05 0.0006892
247 POSITIVE REGULATION OF CELL DEATH 7 605 3.899e-05 0.0007315
248 POSITIVE REGULATION OF CHEMOTAXIS 4 120 3.892e-05 0.0007315
249 CALCIUM ION TRANSMEMBRANE IMPORT INTO CYTOSOL 3 42 4.094e-05 0.0007441
250 PEPTIDYL AMINO ACID MODIFICATION 8 841 4.045e-05 0.0007441
251 CELL CELL ADHESION 7 608 4.024e-05 0.0007441
252 POSITIVE REGULATION OF NUCLEOCYTOPLASMIC TRANSPORT 4 121 4.021e-05 0.0007441
253 REGULATION OF B CELL ACTIVATION 4 121 4.021e-05 0.0007441
254 REGULATION OF HEART GROWTH 3 42 4.094e-05 0.0007441
255 NEGATIVE REGULATION OF CELL DIFFERENTIATION 7 609 4.066e-05 0.0007441
256 CALCIUM ION IMPORT INTO CYTOSOL 3 42 4.094e-05 0.0007441
257 REGULATION OF ADAPTIVE IMMUNE RESPONSE 4 123 4.287e-05 0.0007732
258 ENDOCRINE SYSTEM DEVELOPMENT 4 123 4.287e-05 0.0007732
259 NEGATIVE REGULATION OF PROTEIN MODIFICATION PROCESS 7 616 4.372e-05 0.0007855
260 NEGATIVE REGULATION OF HOMEOSTATIC PROCESS 4 124 4.425e-05 0.0007919
261 KIDNEY EPITHELIUM DEVELOPMENT 4 125 4.566e-05 0.000814
262 REGULATION OF IMMUNE RESPONSE 8 858 4.663e-05 0.0008281
263 RESPONSE TO NITROGEN COMPOUND 8 859 4.702e-05 0.0008318
264 REGULATION OF ALCOHOL BIOSYNTHETIC PROCESS 3 45 5.044e-05 0.000889
265 POSITIVE REGULATION OF PROTEIN LOCALIZATION TO NUCLEUS 4 129 5.164e-05 0.0009067
266 CENTRAL NERVOUS SYSTEM DEVELOPMENT 8 872 5.229e-05 0.0009148
267 CHEMICAL HOMEOSTASIS 8 874 5.315e-05 0.0009262
268 RESPONSE TO DRUG 6 431 5.449e-05 0.0009461
269 MAINTENANCE OF CELL NUMBER 4 132 5.648e-05 0.000977
270 POSITIVE REGULATION OF VASCULATURE DEVELOPMENT 4 133 5.817e-05 0.001002
271 POSITIVE REGULATION OF REACTIVE OXYGEN SPECIES BIOSYNTHETIC PROCESS 3 48 6.128e-05 0.001048
272 REGULATION OF MYOBLAST DIFFERENTIATION 3 48 6.128e-05 0.001048
273 POSITIVE REGULATION OF STRESS ACTIVATED PROTEIN KINASE SIGNALING CASCADE 4 135 6.165e-05 0.001051
274 GLIAL CELL DIFFERENTIATION 4 136 6.345e-05 0.001077
275 REGULATION OF PHOSPHATIDYLINOSITOL 3 KINASE SIGNALING 4 138 6.716e-05 0.001136
276 REGULATION OF SKELETAL MUSCLE TISSUE DEVELOPMENT 3 50 6.929e-05 0.001164
277 NEGATIVE REGULATION OF RESPONSE TO EXTERNAL STIMULUS 5 274 6.921e-05 0.001164
278 INFLAMMATORY RESPONSE 6 454 7.267e-05 0.001216
279 REGULATION OF CHROMOSOME ORGANIZATION 5 278 7.412e-05 0.001232
280 NEGATIVE REGULATION OF CELL COMMUNICATION 9 1192 7.405e-05 0.001232
281 POSITIVE REGULATION OF STRIATED MUSCLE CELL DIFFERENTIATION 3 52 7.796e-05 0.001291
282 CARDIAC CHAMBER DEVELOPMENT 4 144 7.923e-05 0.001304
283 POSITIVE REGULATION OF CYTOPLASMIC TRANSPORT 5 282 7.929e-05 0.001304
284 REGULATION OF BINDING 5 283 8.062e-05 0.001321
285 REGULATION OF NITRIC OXIDE BIOSYNTHETIC PROCESS 3 53 8.255e-05 0.001338
286 CYTOSOLIC CALCIUM ION TRANSPORT 3 53 8.255e-05 0.001338
287 NEGATIVE REGULATION OF EPITHELIAL CELL MIGRATION 3 53 8.255e-05 0.001338
288 NEGATIVE REGULATION OF CELLULAR COMPONENT ORGANIZATION 7 684 8.465e-05 0.001368
289 CARTILAGE DEVELOPMENT 4 147 8.583e-05 0.001381
290 POSITIVE REGULATION OF TRANSPORT 8 936 8.61e-05 0.001381
291 DIGESTIVE SYSTEM DEVELOPMENT 4 148 8.812e-05 0.001409
292 REGULATION OF CYTOKINE SECRETION 4 149 9.045e-05 0.001436
293 REGULATION OF CELLULAR RESPONSE TO STRESS 7 691 9.023e-05 0.001436
294 REGULATION OF B CELL PROLIFERATION 3 55 9.224e-05 0.00146
295 DEFENSE RESPONSE 9 1231 9.495e-05 0.001498
296 REGULATION OF PROTEIN LOCALIZATION 8 950 9.552e-05 0.001502
297 REGULATION OF MUSCLE CELL DIFFERENTIATION 4 152 9.77e-05 0.001531
298 REGULATION OF CYTOPLASMIC TRANSPORT 6 481 9.989e-05 0.00156
299 ADAPTIVE IMMUNE RESPONSE BASED ON SOMATIC RECOMBINATION OF IMMUNE RECEPTORS BUILT FROM IMMUNOGLOBULIN SUPERFAMILY DOMAINS 4 154 0.0001028 0.001594
300 POSITIVE REGULATION OF PEPTIDASE ACTIVITY 4 154 0.0001028 0.001594
301 UROGENITAL SYSTEM DEVELOPMENT 5 299 0.0001044 0.001614
302 REGULATION OF LEUKOCYTE MEDIATED IMMUNITY 4 156 0.000108 0.001653
303 POSITIVE REGULATION OF IMMUNE EFFECTOR PROCESS 4 156 0.000108 0.001653
304 NEGATIVE REGULATION OF RESPONSE TO WOUNDING 4 156 0.000108 0.001653
305 REGULATION OF JNK CASCADE 4 159 0.0001163 0.001774
306 REGULATION OF MONOOXYGENASE ACTIVITY 3 60 0.0001197 0.001808
307 CHONDROCYTE DIFFERENTIATION 3 60 0.0001197 0.001808
308 LEUKOCYTE HOMEOSTASIS 3 60 0.0001197 0.001808
309 REGULATION OF INTERLEUKIN 8 PRODUCTION 3 61 0.0001257 0.001869
310 POSITIVE REGULATION OF RESPONSE TO WOUNDING 4 162 0.000125 0.001869
311 POSITIVE REGULATION OF PEPTIDYL TYROSINE PHOSPHORYLATION 4 162 0.000125 0.001869
312 HEMOSTASIS 5 311 0.0001256 0.001869
313 POSITIVE REGULATION OF CELL MORPHOGENESIS INVOLVED IN DIFFERENTIATION 4 162 0.000125 0.001869
314 REGULATION OF CYTOSKELETON ORGANIZATION 6 502 0.0001262 0.001871
315 POSITIVE REGULATION OF HEMOPOIESIS 4 163 0.000128 0.00189
316 CARDIAC VENTRICLE MORPHOGENESIS 3 62 0.000132 0.001943
317 CARDIAC MUSCLE ADAPTATION 2 11 0.0001352 0.001953
318 POSITIVE REGULATION OF CELL FATE COMMITMENT 2 11 0.0001352 0.001953
319 MUSCLE HYPERTROPHY IN RESPONSE TO STRESS 2 11 0.0001352 0.001953
320 CARDIAC CHAMBER FORMATION 2 11 0.0001352 0.001953
321 NEGATIVE REGULATION OF INTERLEUKIN 17 PRODUCTION 2 11 0.0001352 0.001953
322 CARDIAC MUSCLE HYPERTROPHY IN RESPONSE TO STRESS 2 11 0.0001352 0.001953
323 CELL MORPHOGENESIS INVOLVED IN DIFFERENTIATION 6 513 0.0001421 0.002047
324 POSITIVE REGULATION OF PRODUCTION OF MOLECULAR MEDIATOR OF IMMUNE RESPONSE 3 64 0.0001451 0.002083
325 CALCIUM ION IMPORT 3 65 0.0001519 0.002168
326 REGULATION OF CHEMOKINE PRODUCTION 3 65 0.0001519 0.002168
327 POSITIVE REGULATION OF ERK1 AND ERK2 CASCADE 4 172 0.0001574 0.002239
328 LENS DEVELOPMENT IN CAMERA TYPE EYE 3 66 0.000159 0.002255
329 REGULATION OF VITAMIN METABOLIC PROCESS 2 12 0.0001621 0.002285
330 REGULATION OF MACROPHAGE CYTOKINE PRODUCTION 2 12 0.0001621 0.002285
331 GLIOGENESIS 4 175 0.0001682 0.002364
332 POSITIVE REGULATION OF ENDOTHELIAL CELL PROLIFERATION 3 68 0.0001737 0.002435
333 POSITIVE REGULATION OF LYMPHOCYTE MEDIATED IMMUNITY 3 69 0.0001814 0.00252
334 NEGATIVE REGULATION OF OSSIFICATION 3 69 0.0001814 0.00252
335 POSITIVE REGULATION OF AXONOGENESIS 3 69 0.0001814 0.00252
336 REGULATION OF DNA METABOLIC PROCESS 5 340 0.0001904 0.002618
337 NEGATIVE REGULATION OF MONOOXYGENASE ACTIVITY 2 13 0.0001913 0.002618
338 REGULATION OF CELL FATE SPECIFICATION 2 13 0.0001913 0.002618
339 REGULATION OF MHC CLASS II BIOSYNTHETIC PROCESS 2 13 0.0001913 0.002618
340 MESODERMAL CELL FATE COMMITMENT 2 13 0.0001913 0.002618
341 REGULATION OF PROTEIN IMPORT 4 183 0.0001996 0.002724
342 POSITIVE REGULATION OF ADAPTIVE IMMUNE RESPONSE 3 73 0.0002144 0.002876
343 ERYTHROCYTE HOMEOSTASIS 3 73 0.0002144 0.002876
344 PANCREAS DEVELOPMENT 3 73 0.0002144 0.002876
345 REGULATION OF ORGAN GROWTH 3 73 0.0002144 0.002876
346 REGULATION OF PLASMA MEMBRANE ORGANIZATION 3 73 0.0002144 0.002876
347 REGULATION OF CELLULAR PROTEIN LOCALIZATION 6 552 0.0002115 0.002876
348 REGULATION OF PODOSOME ASSEMBLY 2 14 0.000223 0.002968
349 CARDIAC MUSCLE CELL DIFFERENTIATION 3 74 0.0002233 0.002968
350 REGULATION OF EXTRACELLULAR MATRIX DISASSEMBLY 2 14 0.000223 0.002968
351 MESENCHYME DEVELOPMENT 4 190 0.0002304 0.003055
352 POSITIVE REGULATION OF CELLULAR PROTEIN LOCALIZATION 5 360 0.0002481 0.003279
353 CONNECTIVE TISSUE DEVELOPMENT 4 194 0.0002495 0.003289
354 CELLULAR CHEMICAL HOMEOSTASIS 6 570 0.0002515 0.003305
355 HYALURONAN CATABOLIC PROCESS 2 15 0.000257 0.003313
356 NEGATIVE REGULATION OF HISTONE ACETYLATION 2 15 0.000257 0.003313
357 POSITIVE REGULATION OF RESPONSE TO OXIDATIVE STRESS 2 15 0.000257 0.003313
358 INTERFERON GAMMA PRODUCTION 2 15 0.000257 0.003313
359 POSITIVE REGULATION OF ANTIGEN RECEPTOR MEDIATED SIGNALING PATHWAY 2 15 0.000257 0.003313
360 MUSCLE CELL FATE COMMITMENT 2 15 0.000257 0.003313
361 RESPONSE TO ALCOHOL 5 362 0.0002545 0.003313
362 RENAL TUBULE DEVELOPMENT 3 78 0.0002609 0.003346
363 BLOOD VESSEL MORPHOGENESIS 5 364 0.0002611 0.003346
364 REGULATION OF STRESS ACTIVATED PROTEIN KINASE SIGNALING CASCADE 4 197 0.0002645 0.003382
365 ION HOMEOSTASIS 6 576 0.0002661 0.003392
366 REGULATION OF LEUKOCYTE APOPTOTIC PROCESS 3 79 0.0002709 0.003444
367 REGULATION OF ENDOCYTOSIS 4 199 0.0002749 0.003476
368 CELL MORPHOGENESIS INVOLVED IN NEURON DIFFERENTIATION 5 368 0.0002746 0.003476
369 POSITIVE REGULATION OF INTRACELLULAR TRANSPORT 5 370 0.0002815 0.00355
370 CARDIAC RIGHT VENTRICLE MORPHOGENESIS 2 16 0.0002935 0.003681
371 POSITIVE REGULATION OF HUMORAL IMMUNE RESPONSE 2 16 0.0002935 0.003681
372 RECEPTOR METABOLIC PROCESS 3 82 0.0003024 0.003772
373 KIDNEY MORPHOGENESIS 3 82 0.0003024 0.003772
374 REGULATION OF LEUKOCYTE PROLIFERATION 4 206 0.0003136 0.003891
375 ORGAN REGENERATION 3 83 0.0003134 0.003891
376 REGULATION OF INTRACELLULAR PROTEIN TRANSPORT 5 381 0.0003222 0.003987
377 POSITIVE REGULATION OF MUSCLE CELL DIFFERENTIATION 3 84 0.0003246 0.004007
378 CARDIAC SEPTUM DEVELOPMENT 3 85 0.0003361 0.004105
379 REGULATION OF STRIATED MUSCLE CELL DIFFERENTIATION 3 85 0.0003361 0.004105
380 POSITIVE REGULATION OF CELL CYCLE ARREST 3 85 0.0003361 0.004105
381 POSITIVE REGULATION OF LEUKOCYTE MEDIATED IMMUNITY 3 85 0.0003361 0.004105
382 POSITIVE REGULATION OF PROTEIN SECRETION 4 211 0.0003434 0.004183
383 REGULATION OF TRANSPORT 10 1804 0.0003511 0.004266
384 REGULATION OF PEPTIDYL TYROSINE PHOSPHORYLATION 4 213 0.0003559 0.004313
385 REGULATION OF PEPTIDASE ACTIVITY 5 392 0.0003671 0.004437
386 MYELOID CELL HOMEOSTASIS 3 88 0.0003723 0.004467
387 REGULATION OF HETEROTYPIC CELL CELL ADHESION 2 18 0.0003734 0.004467
388 CATECHOLAMINE BIOSYNTHETIC PROCESS 2 18 0.0003734 0.004467
389 CATECHOL CONTAINING COMPOUND BIOSYNTHETIC PROCESS 2 18 0.0003734 0.004467
390 POSITIVE REGULATION OF HOMEOSTATIC PROCESS 4 216 0.0003753 0.004478
391 RESPONSE TO ESTROGEN 4 218 0.0003886 0.004601
392 CELLULAR RESPONSE TO STEROID HORMONE STIMULUS 4 218 0.0003886 0.004601
393 REGULATION OF PROTEIN LOCALIZATION TO NUCLEUS 4 218 0.0003886 0.004601
394 REGULATION OF OXIDOREDUCTASE ACTIVITY 3 90 0.0003977 0.004675
395 REGULATION OF INTRACELLULAR TRANSPORT 6 621 0.0003979 0.004675
396 MESONEPHROS DEVELOPMENT 3 90 0.0003977 0.004675
397 REGULATION OF INTERLEUKIN 5 PRODUCTION 2 19 0.000417 0.004838
398 REGULATION OF INFLAMMATORY RESPONSE TO ANTIGENIC STIMULUS 2 19 0.000417 0.004838
399 THYMIC T CELL SELECTION 2 19 0.000417 0.004838
400 CELLULAR RESPONSE TO FLUID SHEAR STRESS 2 19 0.000417 0.004838
401 ASTROCYTE DEVELOPMENT 2 19 0.000417 0.004838
402 NEGATIVE REGULATION OF CELL ADHESION 4 223 0.0004234 0.004901
403 POSITIVE REGULATION OF CELLULAR COMPONENT BIOGENESIS 5 406 0.0004311 0.004965
404 EMBRYONIC ORGAN DEVELOPMENT 5 406 0.0004311 0.004965
405 NEPHRON EPITHELIUM DEVELOPMENT 3 93 0.0004378 0.00503
406 POSITIVE REGULATION OF SEQUENCE SPECIFIC DNA BINDING TRANSCRIPTION FACTOR ACTIVITY 4 228 0.0004604 0.005276
407 ACTIVATION OF CYSTEINE TYPE ENDOPEPTIDASE ACTIVITY 3 95 0.000466 0.005327
408 REGULATION OF CELLULAR RESPONSE TO GROWTH FACTOR STIMULUS 4 229 0.000468 0.005338
409 NEGATIVE REGULATION OF CELL PROLIFERATION 6 643 0.0004787 0.005446
410 CARDIOCYTE DIFFERENTIATION 3 96 0.0004805 0.005453
411 REGULATION OF LEUKOCYTE DIFFERENTIATION 4 232 0.0004916 0.005565
412 NECROPTOTIC PROCESS 2 21 0.000511 0.00573
413 SYMPATHETIC NERVOUS SYSTEM DEVELOPMENT 2 21 0.000511 0.00573
414 NEGATIVE REGULATION OF PROTEIN ACETYLATION 2 21 0.000511 0.00573
415 REGULATION OF ENDOTHELIAL CELL PROLIFERATION 3 98 0.0005104 0.00573
416 REGULATION OF IMMUNE EFFECTOR PROCESS 5 424 0.0005252 0.005875
417 NEGATIVE REGULATION OF INFLAMMATORY RESPONSE 3 100 0.0005414 0.006027
418 LIMBIC SYSTEM DEVELOPMENT 3 100 0.0005414 0.006027
419 NEGATIVE REGULATION OF CYTOKINE PRODUCTION INVOLVED IN IMMUNE RESPONSE 2 22 0.0005616 0.006192
420 REGULATION OF DOPAMINE SECRETION 2 22 0.0005616 0.006192
421 REGULATION OF INTERLEUKIN 17 PRODUCTION 2 22 0.0005616 0.006192
422 POSITIVE REGULATION OF MESONEPHROS DEVELOPMENT 2 22 0.0005616 0.006192
423 REGULATION OF ORGAN MORPHOGENESIS 4 242 0.0005761 0.006337
424 REGULATION OF CALCIUM ION IMPORT 3 103 0.0005902 0.006477
425 DEVELOPMENTAL GROWTH INVOLVED IN MORPHOGENESIS 3 104 0.0006071 0.006647
426 POSITIVE REGULATION OF ALCOHOL BIOSYNTHETIC PROCESS 2 23 0.0006144 0.006649
427 SYNAPTIC VESICLE RECYCLING 2 23 0.0006144 0.006649
428 REGULATION OF SUPEROXIDE METABOLIC PROCESS 2 23 0.0006144 0.006649
429 STRIATED MUSCLE ADAPTATION 2 23 0.0006144 0.006649
430 REGULATION OF GTPASE ACTIVITY 6 673 0.000609 0.006649
431 CELLULAR HOMEOSTASIS 6 676 0.0006235 0.006715
432 RESPONSE TO VIRUS 4 247 0.000622 0.006715
433 CARDIAC VENTRICLE DEVELOPMENT 3 106 0.0006418 0.006897
434 NEGATIVE REGULATION OF MYOBLAST DIFFERENTIATION 2 24 0.0006696 0.007179
435 REGULATION OF CELL CYCLE ARREST 3 108 0.0006777 0.007249
436 ENZYME LINKED RECEPTOR PROTEIN SIGNALING PATHWAY 6 689 0.0006891 0.007354
437 POSITIVE REGULATION OF LEUKOCYTE MIGRATION 3 109 0.0006961 0.007412
438 FORMATION OF PRIMARY GERM LAYER 3 110 0.0007149 0.007577
439 NEURON MIGRATION 3 110 0.0007149 0.007577
440 SKELETAL SYSTEM DEVELOPMENT 5 455 0.0007229 0.007645
441 LENS FIBER CELL DIFFERENTIATION 2 25 0.0007271 0.007672
442 POSITIVE REGULATION OF CELLULAR AMIDE METABOLIC PROCESS 3 111 0.0007339 0.007691
443 POSITIVE REGULATION OF INTRACELLULAR PROTEIN TRANSPORT 4 258 0.0007322 0.007691
444 COLUMNAR CUBOIDAL EPITHELIAL CELL DIFFERENTIATION 3 111 0.0007339 0.007691
445 LEUKOCYTE MIGRATION 4 259 0.0007428 0.007767
446 ZYMOGEN ACTIVATION 3 112 0.0007533 0.007859
447 REGULATION OF STEM CELL DIFFERENTIATION 3 113 0.000773 0.008047
448 POSITIVE REGULATION OF SKELETAL MUSCLE TISSUE DEVELOPMENT 2 26 0.0007869 0.008047
449 POSITIVE REGULATION OF B CELL MEDIATED IMMUNITY 2 26 0.0007869 0.008047
450 NEGATIVE REGULATION OF NERVOUS SYSTEM DEVELOPMENT 4 262 0.0007755 0.008047
451 REGULATION OF MESONEPHROS DEVELOPMENT 2 26 0.0007869 0.008047
452 NEGATIVE REGULATION OF OXIDOREDUCTASE ACTIVITY 2 26 0.0007869 0.008047
453 POSITIVE REGULATION OF IMMUNOGLOBULIN MEDIATED IMMUNE RESPONSE 2 26 0.0007869 0.008047
454 MESODERMAL CELL DIFFERENTIATION 2 26 0.0007869 0.008047
455 REGULATION OF CELL FATE COMMITMENT 2 26 0.0007869 0.008047
456 POSITIVE REGULATION OF ENDOCYTOSIS 3 114 0.000793 0.008057
457 REGULATION OF LYMPHOCYTE MEDIATED IMMUNITY 3 114 0.000793 0.008057
458 REGULATION OF EMBRYONIC DEVELOPMENT 3 114 0.000793 0.008057
459 HEAD DEVELOPMENT 6 709 0.0008004 0.008113
460 HEART DEVELOPMENT 5 466 0.000805 0.008142
461 NEGATIVE REGULATION OF EPITHELIAL CELL PROLIFERATION 3 115 0.0008134 0.008174
462 CELLULAR RESPONSE TO ALCOHOL 3 115 0.0008134 0.008174
463 NEPHRON DEVELOPMENT 3 115 0.0008134 0.008174
464 PROTEIN SECRETION 3 116 0.0008341 0.008364
465 CELL PROLIFERATION IN FOREBRAIN 2 27 0.000849 0.008423
466 EXCITATORY POSTSYNAPTIC POTENTIAL 2 27 0.000849 0.008423
467 REGULATION OF HISTONE H3 K4 METHYLATION 2 27 0.000849 0.008423
468 AXIS ELONGATION 2 27 0.000849 0.008423
469 POSITIVE REGULATION OF NF KAPPAB IMPORT INTO NUCLEUS 2 27 0.000849 0.008423
470 POSITIVE REGULATION OF CELL DEVELOPMENT 5 472 0.0008526 0.00844
471 MAMMARY GLAND DEVELOPMENT 3 117 0.0008551 0.008448
472 MESODERM DEVELOPMENT 3 118 0.0008765 0.00864
473 REGULATION OF T CELL RECEPTOR SIGNALING PATHWAY 2 28 0.0009134 0.008873
474 NECROTIC CELL DEATH 2 28 0.0009134 0.008873
475 REGULATION OF FIBROBLAST MIGRATION 2 28 0.0009134 0.008873
476 POSITIVE REGULATION OF ACUTE INFLAMMATORY RESPONSE 2 28 0.0009134 0.008873
477 RESPONSE TO INORGANIC SUBSTANCE 5 479 0.0009107 0.008873
478 MUSCLE HYPERTROPHY 2 28 0.0009134 0.008873
479 REGULATION OF SPROUTING ANGIOGENESIS 2 28 0.0009134 0.008873
480 CYTOKINE PRODUCTION 3 120 0.0009202 0.00892
481 ESTABLISHMENT OF LOCALIZATION IN CELL 9 1676 0.0009481 0.009171
482 REGULATION OF EPITHELIAL CELL DIFFERENTIATION 3 122 0.0009653 0.009318
483 NEGATIVE REGULATION OF PRODUCTION OF MOLECULAR MEDIATOR OF IMMUNE RESPONSE 2 29 0.0009801 0.009364
484 REGULATION OF EXTRACELLULAR MATRIX ORGANIZATION 2 29 0.0009801 0.009364
485 PROTEIN IMPORT INTO NUCLEUS TRANSLOCATION 2 29 0.0009801 0.009364
486 REGULATION OF HEART MORPHOGENESIS 2 29 0.0009801 0.009364
487 MUSCLE ADAPTATION 2 29 0.0009801 0.009364
488 RESPONSE TO ABIOTIC STIMULUS 7 1024 0.0009856 0.009397
489 INOSITOL LIPID MEDIATED SIGNALING 3 124 0.001012 0.009627
490 SENSORY ORGAN DEVELOPMENT 5 493 0.001036 0.009837
491 SMOOTH MUSCLE CELL DIFFERENTIATION 2 30 0.001049 0.009922
492 POSITIVE REGULATION OF CYTOKINE PRODUCTION INVOLVED IN IMMUNE RESPONSE 2 30 0.001049 0.009922
NumGOOverlapSizeP ValueAdj. P Value
1 TRANSCRIPTIONAL ACTIVATOR ACTIVITY RNA POLYMERASE II TRANSCRIPTION REGULATORY REGION SEQUENCE SPECIFIC BINDING 10 315 3.867e-11 3.593e-08
2 REGULATORY REGION NUCLEIC ACID BINDING 13 818 1.378e-10 4.267e-08
3 RNA POLYMERASE II TRANSCRIPTION FACTOR ACTIVITY SEQUENCE SPECIFIC DNA BINDING 12 629 1.071e-10 4.267e-08
4 NUCLEIC ACID BINDING TRANSCRIPTION FACTOR ACTIVITY 14 1199 1.222e-09 2.839e-07
5 PROTEIN TYROSINE KINASE ACTIVITY 7 176 1.014e-08 1.884e-06
6 TRANSCRIPTION FACTOR ACTIVITY RNA POLYMERASE II CORE PROMOTER PROXIMAL REGION SEQUENCE SPECIFIC BINDING 8 328 3.588e-08 5.555e-06
7 TRANSCRIPTIONAL ACTIVATOR ACTIVITY RNA POLYMERASE II CORE PROMOTER PROXIMAL REGION SEQUENCE SPECIFIC BINDING 7 226 5.675e-08 7.531e-06
8 CORE PROMOTER BINDING 6 152 1.343e-07 1.56e-05
9 TRANSCRIPTION FACTOR ACTIVITY RNA POLYMERASE II DISTAL ENHANCER SEQUENCE SPECIFIC BINDING 5 90 3.017e-07 3.115e-05
10 CORE PROMOTER SEQUENCE SPECIFIC DNA BINDING 5 101 5.371e-07 4.99e-05
11 RNA POLYMERASE II TRANSCRIPTION FACTOR BINDING 5 104 6.215e-07 5.249e-05
12 DOUBLE STRANDED DNA BINDING 9 764 2.102e-06 0.0001627
13 SEQUENCE SPECIFIC DNA BINDING 10 1037 3.048e-06 0.0002178
14 TRANSCRIPTIONAL ACTIVATOR ACTIVITY RNA POLYMERASE II DISTAL ENHANCER SEQUENCE SPECIFIC BINDING 3 26 9.434e-06 0.000626
15 RECEPTOR BINDING 11 1476 1.031e-05 0.0006385
16 CYTOKINE RECEPTOR ACTIVITY 4 89 1.198e-05 0.0006954
17 ENHANCER BINDING 4 93 1.426e-05 0.0007792
18 TRANSCRIPTION FACTOR BINDING 7 524 1.551e-05 0.0008007
19 CORE PROMOTER PROXIMAL REGION DNA BINDING 6 371 2.358e-05 0.001106
20 CYTOKINE ACTIVITY 5 219 2.38e-05 0.001106
21 PROTEIN KINASE ACTIVITY 7 640 5.57e-05 0.002464
22 CYTOKINE RECEPTOR BINDING 5 271 6.57e-05 0.002774
23 TRANSCRIPTIONAL REPRESSOR ACTIVITY RNA POLYMERASE II ACTIVATING TRANSCRIPTION FACTOR BINDING 3 53 8.255e-05 0.003195
24 RNA POLYMERASE II CORE PROMOTER SEQUENCE SPECIFIC DNA BINDING 3 53 8.255e-05 0.003195
25 GROWTH FACTOR ACTIVITY 4 160 0.0001191 0.004427
26 RNA POLYMERASE II DISTAL ENHANCER SEQUENCE SPECIFIC DNA BINDING 3 65 0.0001519 0.005428
27 MOLECULAR FUNCTION REGULATOR 9 1353 0.0001953 0.00672
28 SIGNAL TRANSDUCER ACTIVITY 10 1731 0.0002509 0.008048
29 MACROMOLECULAR COMPLEX BINDING 9 1399 0.0002512 0.008048
30 KINASE ACTIVITY 7 842 0.0003058 0.009163
31 TRANSCRIPTION FACTOR ACTIVITY PROTEIN BINDING 6 588 0.0002972 0.009163
NumGOOverlapSizeP ValueAdj. P Value
1 TRANSCRIPTION FACTOR COMPLEX 7 298 3.717e-07 0.000217

Over-represented Pathway

NumPathwayPathviewOverlapSizeP ValueAdj. P Value
1 hsa04640_Hematopoietic_cell_lineage 4 88 1.145e-05 0.002061
2 hsa04380_Osteoclast_differentiation 4 128 5.009e-05 0.00374
3 hsa04010_MAPK_signaling_pathway 5 268 6.233e-05 0.00374
4 hsa04630_Jak.STAT_signaling_pathway 4 155 0.0001054 0.004742
5 hsa04014_Ras_signaling_pathway 4 236 0.0005242 0.01887
6 hsa04660_T_cell_receptor_signaling_pathway 3 108 0.0006777 0.02033
7 hsa04650_Natural_killer_cell_mediated_cytotoxicity 3 136 0.00132 0.03395
8 hsa04672_Intestinal_immune_network_for_IgA_production 2 49 0.002783 0.06262
9 hsa04664_Fc_epsilon_RI_signaling_pathway 2 79 0.007076 0.1415
10 hsa04350_TGF.beta_signaling_pathway 2 85 0.008151 0.1457
11 hsa04210_Apoptosis 2 89 0.008905 0.1457
12 hsa04620_Toll.like_receptor_signaling_pathway 2 102 0.01156 0.1735
13 hsa04151_PI3K_AKT_signaling_pathway 3 351 0.01825 0.2527
14 hsa04390_Hippo_signaling_pathway 2 154 0.02512 0.323
15 hsa04062_Chemokine_signaling_pathway 2 189 0.0366 0.4392
16 hsa04810_Regulation_of_actin_cytoskeleton 2 214 0.04581 0.4851

lncRNA-mediated sponge

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Num lncRNA miRNAs           miRNAs count     Gene Sponge regulatory network lncRNA log2FC lncRNA pvalue Gene log2FC Gene pvalue lncRNA-gene Pearson correlation
1 LINC00511 hsa-miR-139-3p;hsa-miR-145-5p;hsa-miR-146b-3p;hsa-miR-30a-3p;hsa-miR-30a-5p;hsa-miR-30c-5p;hsa-miR-30d-5p;hsa-miR-30e-3p;hsa-miR-320a;hsa-miR-342-5p 10 SOX4 Sponge network 2.848 0 1.654 0 0.312

Quest ID: e97e36c4b3baf608e4c3a2a24d1fc5b5