Explanation
This regulatory network was inferred from the input dataset. The miRNAs and mRNAs are
presented as round and rectangle nodes respectively. The numerical value popped up upon mouse over the gene node is the log2 transformed fold-change of the gene expression between the two groups. All of the nodes are clickable, and the detailed information of the miRNAs/mRNAs and related cancer pathway will be displayed in another window. The edges between nodes are supported by both interactions (predicted or experimentally verified) and correlations learnt from cancer dataset. The numerical value popped up upon mouse over the edge is the correlation beat value (effect size) between the two nodes. The experimental evidences of the edges reported in previous cancer studies are highlighted by red/orange color. All of these information can be accessed by the "mouse-over" action. This network shows a full map of the miRNA-mRNA regulation of the input gene list(s), and the hub miRNAs (with the high network degree/betweenness centrality) would be the potential cancer drivers or tumor suppressors. The full result table can be accessed in the "Regulations" tab.
"miRNACancerMAP" is also a network visualization tool for users to draw their regulatory network by personal customization. Users can set the complexity of the network by limiting the number of nodes or edges. And the color of the nodes can be defined by different categories of the mRNAs and miRNAs, such as Gene-Ontology, pathway, and expression status. Users can also select to use network degree or network betweenness centrality to define the node size. And edges can be black or colored by the correlation. Purple edge means negative correlation (mostly found between miRNA and mRNA), and blue edge means positive correlation (found in PPI or miRNA-miRNA sponge effect). We can also add the protein-protein interactions (PPI) into the network. This result will show the cluster of genes regulated by some specific miRNAs. Additionally, miRNA-miRNA edges can be added by the "miRNA sponge" button, presenting some clusters of miRNAs that have the interactions via sponge effect.
miRNA-gene regulations
| Num | microRNA | Gene | miRNA log2FC | miRNA pvalue | Gene log2FC | Gene pvalue | Interaction | Correlation beta | Correlation P-value | PMID | Reported in cancer studies |
|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | hsa-miR-130b-3p | NRP1 | 3.54 | 0 | -0.61 | 0.02915 | miRNATAP | -0.18 | 0 | 26573160 | NRP1 is targeted by miR 130a and miR 130b and is associated with multidrug resistance in epithelial ovarian cancer based on integrated gene network analysis |
| 2 | hsa-miR-141-3p | NRP1 | 5.02 | 0 | -0.61 | 0.02915 | TargetScan; miRNATAP | -0.26 | 0 | NA | |
| 3 | hsa-miR-148a-3p | NRP1 | 1.27 | 0 | -0.61 | 0.02915 | miRNATAP | -0.15 | 0.00242 | 26967387 | Mechanistically miR-148a appears to suppress the extravasation process of cancer cells likely by targeting two genes WNT1 and NRP1 in a cell non-autonomous manner |
| 4 | hsa-miR-16-1-3p | NRP1 | 2.57 | 0 | -0.61 | 0.02915 | mirMAP | -0.17 | 0.00054 | NA | |
| 5 | hsa-miR-16-2-3p | NRP1 | 2.32 | 0 | -0.61 | 0.02915 | mirMAP | -0.14 | 0.00753 | NA | |
| 6 | hsa-miR-16-5p | NRP1 | 1.76 | 0 | -0.61 | 0.02915 | miRNAWalker2 validate | -0.17 | 0.00701 | NA | |
| 7 | hsa-miR-186-5p | NRP1 | 1.47 | 0 | -0.61 | 0.02915 | miRNAWalker2 validate; mirMAP; miRNATAP | -0.3 | 2.0E-5 | NA | |
| 8 | hsa-miR-194-5p | NRP1 | 1.9 | 0 | -0.61 | 0.02915 | miRNATAP | -0.27 | 0 | NA | |
| 9 | hsa-miR-197-3p | NRP1 | 1.76 | 0 | -0.61 | 0.02915 | miRNATAP | -0.16 | 0.00323 | NA | |
| 10 | hsa-miR-200a-3p | NRP1 | 4.59 | 0 | -0.61 | 0.02915 | miRNATAP | -0.25 | 0 | NA | |
| 11 | hsa-miR-28-5p | NRP1 | 0.23 | 0.07429 | -0.61 | 0.02915 | miRanda | -0.42 | 0.00013 | NA | |
| 12 | hsa-miR-301a-3p | NRP1 | 2.81 | 0 | -0.61 | 0.02915 | miRNATAP | -0.2 | 0 | NA | |
| 13 | hsa-miR-30b-5p | NRP1 | 0.8 | 0.00013 | -0.61 | 0.02915 | mirMAP | -0.43 | 0 | NA | |
| 14 | hsa-miR-30c-5p | NRP1 | 0.78 | 0.00029 | -0.61 | 0.02915 | mirMAP; miRNATAP | -0.41 | 0 | NA | |
| 15 | hsa-miR-30d-5p | NRP1 | 0.68 | 0.00271 | -0.61 | 0.02915 | mirMAP; miRNATAP | -0.43 | 0 | NA | |
| 16 | hsa-miR-30e-5p | NRP1 | 1.24 | 0 | -0.61 | 0.02915 | mirMAP | -0.53 | 0 | NA | |
| 17 | hsa-miR-320a | NRP1 | 0.44 | 0.03902 | -0.61 | 0.02915 | PITA; miRanda; miRNATAP | -0.32 | 0 | 22134529 | miR-320a directly binds to the 3'UTR of neuropilin 1 NRP-1 a protein that functions as a co-receptor of vascular epithelial growth factor |
| 18 | hsa-miR-320b | NRP1 | 1.56 | 0 | -0.61 | 0.02915 | PITA; miRanda; miRNATAP | -0.24 | 0 | NA | |
| 19 | hsa-miR-324-5p | NRP1 | 2.96 | 0 | -0.61 | 0.02915 | miRanda | -0.17 | 2.0E-5 | NA | |
| 20 | hsa-miR-330-5p | NRP1 | 1.15 | 0 | -0.61 | 0.02915 | miRanda | -0.18 | 0.00188 | NA | |
| 21 | hsa-miR-335-5p | NRP1 | 1.77 | 0 | -0.61 | 0.02915 | miRNAWalker2 validate | -0.17 | 0 | NA | |
| 22 | hsa-miR-3607-3p | NRP1 | 2.69 | 0 | -0.61 | 0.02915 | miRNATAP | -0.12 | 0.00156 | NA | |
| 23 | hsa-miR-361-5p | NRP1 | 0.97 | 0 | -0.61 | 0.02915 | miRanda; miRNATAP | -0.49 | 0 | NA | |
| 24 | hsa-miR-421 | NRP1 | 1.18 | 1.0E-5 | -0.61 | 0.02915 | miRanda | -0.13 | 0.00955 | NA | |
| 25 | hsa-miR-429 | NRP1 | 4.49 | 0 | -0.61 | 0.02915 | miRanda; miRNATAP | -0.25 | 0 | NA | |
| 26 | hsa-miR-454-3p | NRP1 | 2.47 | 0 | -0.61 | 0.02915 | miRNATAP | -0.2 | 7.0E-5 | NA | |
| 27 | hsa-miR-582-5p | NRP1 | 0.61 | 0.03299 | -0.61 | 0.02915 | PITA; miRNATAP | -0.26 | 0 | NA | |
| 28 | hsa-miR-590-3p | NRP1 | 2.59 | 0 | -0.61 | 0.02915 | PITA; miRanda; mirMAP | -0.16 | 0.00141 | NA | |
| 29 | hsa-miR-590-5p | NRP1 | 3.18 | 0 | -0.61 | 0.02915 | miRanda | -0.18 | 5.0E-5 | NA | |
| 30 | hsa-miR-664a-3p | NRP1 | 0.63 | 0.0052 | -0.61 | 0.02915 | mirMAP | -0.43 | 0 | NA | |
| 31 | hsa-miR-7-1-3p | NRP1 | 1.85 | 0 | -0.61 | 0.02915 | mirMAP | -0.12 | 0.02943 | NA | |
| 32 | hsa-miR-944 | NRP1 | 2.91 | 0 | -0.61 | 0.02915 | mirMAP | -0.15 | 0 | NA |
| Num | GO | Overlap | Size | P Value | Adj. P Value |
|---|---|---|---|---|---|
| 1 | CELL DEVELOPMENT | 31 | 1426 | 9.528e-22 | 4.434e-18 |
| 2 | NEURON DEVELOPMENT | 22 | 687 | 1.988e-18 | 4.625e-15 |
| 3 | NEURON PROJECTION DEVELOPMENT | 19 | 545 | 1.549e-16 | 2.402e-13 |
| 4 | NEUROGENESIS | 26 | 1402 | 3.821e-16 | 3.555e-13 |
| 5 | NEURON DIFFERENTIATION | 22 | 874 | 3.145e-16 | 3.555e-13 |
| 6 | REGULATION OF ANATOMICAL STRUCTURE MORPHOGENESIS | 23 | 1021 | 5.897e-16 | 4.573e-13 |
| 7 | MESENCHYME DEVELOPMENT | 13 | 190 | 3.474e-15 | 2.309e-12 |
| 8 | MOVEMENT OF CELL OR SUBCELLULAR COMPONENT | 24 | 1275 | 6.038e-15 | 3.512e-12 |
| 9 | SEMAPHORIN PLEXIN SIGNALING PATHWAY | 8 | 36 | 5.48e-14 | 2.833e-11 |
| 10 | MESENCHYMAL CELL DIFFERENTIATION | 11 | 134 | 7.494e-14 | 3.487e-11 |
| 11 | CELLULAR COMPONENT MORPHOGENESIS | 20 | 900 | 1.068e-13 | 4.188e-11 |
| 12 | CELL PROJECTION ORGANIZATION | 20 | 902 | 1.113e-13 | 4.188e-11 |
| 13 | STEM CELL DIFFERENTIATION | 12 | 190 | 1.17e-13 | 4.188e-11 |
| 14 | NEURON PROJECTION MORPHOGENESIS | 15 | 402 | 1.559e-13 | 5.1e-11 |
| 15 | NEGATIVE REGULATION OF DEVELOPMENTAL PROCESS | 19 | 801 | 1.644e-13 | 5.1e-11 |
| 16 | REGULATION OF CELL PROLIFERATION | 24 | 1496 | 2.035e-13 | 5.918e-11 |
| 17 | REGULATION OF MULTICELLULAR ORGANISMAL DEVELOPMENT | 25 | 1672 | 2.5e-13 | 6.843e-11 |
| 18 | CELL MOTILITY | 19 | 835 | 3.441e-13 | 7.623e-11 |
| 19 | LOCALIZATION OF CELL | 19 | 835 | 3.441e-13 | 7.623e-11 |
| 20 | CELL MORPHOGENESIS INVOLVED IN DIFFERENTIATION | 16 | 513 | 3.296e-13 | 7.623e-11 |
| 21 | NEGATIVE REGULATION OF CELL DIFFERENTIATION | 17 | 609 | 3.106e-13 | 7.623e-11 |
| 22 | LOCOMOTION | 21 | 1114 | 5.24e-13 | 1.108e-10 |
| 23 | REGULATION OF NERVOUS SYSTEM DEVELOPMENT | 18 | 750 | 6.89e-13 | 1.394e-10 |
| 24 | REGULATION OF AXONOGENESIS | 11 | 168 | 9.181e-13 | 1.78e-10 |
| 25 | REGULATION OF NEURON DIFFERENTIATION | 16 | 554 | 1.063e-12 | 1.978e-10 |
| 26 | NEURAL CREST CELL MIGRATION | 8 | 51 | 1.118e-12 | 2e-10 |
| 27 | CARDIOVASCULAR SYSTEM DEVELOPMENT | 18 | 788 | 1.581e-12 | 2.628e-10 |
| 28 | CIRCULATORY SYSTEM DEVELOPMENT | 18 | 788 | 1.581e-12 | 2.628e-10 |
| 29 | REGULATION OF CELL DIFFERENTIATION | 23 | 1492 | 1.826e-12 | 2.929e-10 |
| 30 | REGULATION OF NEURON PROJECTION DEVELOPMENT | 14 | 408 | 3.526e-12 | 5.469e-10 |
| 31 | NEGATIVE REGULATION OF MULTICELLULAR ORGANISMAL PROCESS | 19 | 983 | 6.056e-12 | 9.09e-10 |
| 32 | CELL PART MORPHOGENESIS | 16 | 633 | 7.946e-12 | 1.155e-09 |
| 33 | AMEBOIDAL TYPE CELL MIGRATION | 10 | 154 | 1.186e-11 | 1.672e-09 |
| 34 | CELL MORPHOGENESIS INVOLVED IN NEURON DIFFERENTIATION | 13 | 368 | 1.621e-11 | 2.219e-09 |
| 35 | REGULATION OF CELL PROJECTION ORGANIZATION | 15 | 558 | 1.705e-11 | 2.267e-09 |
| 36 | HEART DEVELOPMENT | 14 | 466 | 2.083e-11 | 2.692e-09 |
| 37 | TISSUE DEVELOPMENT | 22 | 1518 | 2.264e-11 | 2.847e-09 |
| 38 | NEURAL CREST CELL DIFFERENTIATION | 8 | 75 | 2.816e-11 | 3.448e-09 |
| 39 | GLAND DEVELOPMENT | 13 | 395 | 3.916e-11 | 4.672e-09 |
| 40 | REGULATION OF CELL DEVELOPMENT | 17 | 836 | 4.736e-11 | 5.51e-09 |
| 41 | ORGAN MORPHOGENESIS | 17 | 841 | 5.198e-11 | 5.899e-09 |
| 42 | NEGATIVE REGULATION OF AXON GUIDANCE | 6 | 27 | 9.244e-11 | 1e-08 |
| 43 | CENTRAL NERVOUS SYSTEM DEVELOPMENT | 17 | 872 | 9.132e-11 | 1e-08 |
| 44 | NEGATIVE REGULATION OF NEURON DIFFERENTIATION | 10 | 191 | 1.004e-10 | 1.061e-08 |
| 45 | NEGATIVE REGULATION OF NERVOUS SYSTEM DEVELOPMENT | 11 | 262 | 1.137e-10 | 1.175e-08 |
| 46 | REGULATION OF CELLULAR COMPONENT MOVEMENT | 16 | 771 | 1.487e-10 | 1.504e-08 |
| 47 | REGULATION OF CELL MORPHOGENESIS | 14 | 552 | 1.945e-10 | 1.926e-08 |
| 48 | EMBRYONIC ORGAN MORPHOGENESIS | 11 | 279 | 2.221e-10 | 2.153e-08 |
| 49 | REGULATION OF DEVELOPMENTAL GROWTH | 11 | 289 | 3.229e-10 | 3.005e-08 |
| 50 | REGULATION OF EXTENT OF CELL GROWTH | 8 | 101 | 3.194e-10 | 3.005e-08 |
| 51 | NEGATIVE REGULATION OF AXONOGENESIS | 7 | 65 | 4.929e-10 | 4.497e-08 |
| 52 | NEGATIVE REGULATION OF CELL DEVELOPMENT | 11 | 303 | 5.328e-10 | 4.768e-08 |
| 53 | POSITIVE REGULATION OF DEVELOPMENTAL PROCESS | 18 | 1142 | 6.996e-10 | 6.142e-08 |
| 54 | NEGATIVE REGULATION OF AXON EXTENSION | 6 | 38 | 8.424e-10 | 7.259e-08 |
| 55 | REGULATION OF AXON GUIDANCE | 6 | 39 | 9.935e-10 | 8.405e-08 |
| 56 | REGULATION OF GROWTH | 14 | 633 | 1.153e-09 | 9.581e-08 |
| 57 | ENDOCRINE SYSTEM DEVELOPMENT | 8 | 123 | 1.554e-09 | 1.269e-07 |
| 58 | REGULATION OF CELL MORPHOGENESIS INVOLVED IN DIFFERENTIATION | 11 | 337 | 1.632e-09 | 1.309e-07 |
| 59 | NEGATIVE REGULATION OF DEVELOPMENTAL GROWTH | 7 | 84 | 3.081e-09 | 2.43e-07 |
| 60 | TAXIS | 12 | 464 | 3.749e-09 | 2.908e-07 |
| 61 | VASCULATURE DEVELOPMENT | 12 | 469 | 4.228e-09 | 3.225e-07 |
| 62 | NEURON PROJECTION GUIDANCE | 9 | 205 | 4.43e-09 | 3.325e-07 |
| 63 | REGULATION OF EPITHELIAL CELL PROLIFERATION | 10 | 285 | 4.901e-09 | 3.62e-07 |
| 64 | NEGATIVE REGULATION OF CHEMOTAXIS | 6 | 51 | 5.347e-09 | 3.888e-07 |
| 65 | NEGATIVE REGULATION OF CELL PROJECTION ORGANIZATION | 8 | 144 | 5.434e-09 | 3.89e-07 |
| 66 | HEART MORPHOGENESIS | 9 | 212 | 5.942e-09 | 4.189e-07 |
| 67 | REGULATION OF CELL GROWTH | 11 | 391 | 7.669e-09 | 5.326e-07 |
| 68 | GLAND MORPHOGENESIS | 7 | 97 | 8.503e-09 | 5.818e-07 |
| 69 | NEGATIVE REGULATION OF CELL ADHESION | 9 | 223 | 9.235e-09 | 6.227e-07 |
| 70 | CELL FATE COMMITMENT | 9 | 227 | 1.078e-08 | 7.165e-07 |
| 71 | REGULATION OF CELL ADHESION | 13 | 629 | 1.122e-08 | 7.311e-07 |
| 72 | EMBRYONIC ORGAN DEVELOPMENT | 11 | 406 | 1.131e-08 | 7.311e-07 |
| 73 | EMBRYONIC PATTERN SPECIFICATION | 6 | 58 | 1.184e-08 | 7.548e-07 |
| 74 | GROWTH | 11 | 410 | 1.252e-08 | 7.87e-07 |
| 75 | DEVELOPMENTAL GROWTH INVOLVED IN MORPHOGENESIS | 7 | 104 | 1.385e-08 | 8.596e-07 |
| 76 | NEGATIVE REGULATION OF CELL PROLIFERATION | 13 | 643 | 1.456e-08 | 8.915e-07 |
| 77 | POSITIVE REGULATION OF LOCOMOTION | 11 | 420 | 1.604e-08 | 9.69e-07 |
| 78 | SENSORY ORGAN MORPHOGENESIS | 9 | 239 | 1.685e-08 | 1.005e-06 |
| 79 | DEVELOPMENTAL GROWTH | 10 | 333 | 2.154e-08 | 1.269e-06 |
| 80 | REGULATION OF CELL SIZE | 8 | 172 | 2.193e-08 | 1.276e-06 |
| 81 | POSITIVE REGULATION OF NERVOUS SYSTEM DEVELOPMENT | 11 | 437 | 2.409e-08 | 1.384e-06 |
| 82 | NEGATIVE REGULATION OF CELLULAR COMPONENT ORGANIZATION | 13 | 684 | 3.018e-08 | 1.713e-06 |
| 83 | NEGATIVE REGULATION OF CELL MORPHOGENESIS INVOLVED IN DIFFERENTIATION | 7 | 117 | 3.147e-08 | 1.764e-06 |
| 84 | NEGATIVE REGULATION OF LOCOMOTION | 9 | 263 | 3.846e-08 | 2.13e-06 |
| 85 | HEAD DEVELOPMENT | 13 | 709 | 4.597e-08 | 2.517e-06 |
| 86 | POSITIVE REGULATION OF CELL DEVELOPMENT | 11 | 472 | 5.283e-08 | 2.858e-06 |
| 87 | RESPONSE TO GROWTH FACTOR | 11 | 475 | 5.633e-08 | 3.013e-06 |
| 88 | NEGATIVE CHEMOTAXIS | 5 | 39 | 7e-08 | 3.701e-06 |
| 89 | NEGATIVE REGULATION OF RESPONSE TO STIMULUS | 17 | 1360 | 7.372e-08 | 3.854e-06 |
| 90 | BIOLOGICAL ADHESION | 15 | 1032 | 7.529e-08 | 3.893e-06 |
| 91 | BRANCHING INVOLVED IN SALIVARY GLAND MORPHOGENESIS | 4 | 16 | 9.088e-08 | 4.647e-06 |
| 92 | POSITIVE REGULATION OF MULTICELLULAR ORGANISMAL PROCESS | 17 | 1395 | 1.065e-07 | 5.387e-06 |
| 93 | CRANIAL NERVE DEVELOPMENT | 5 | 43 | 1.161e-07 | 5.807e-06 |
| 94 | CARDIAC SEPTUM DEVELOPMENT | 6 | 85 | 1.209e-07 | 5.984e-06 |
| 95 | CARDIAC CHAMBER DEVELOPMENT | 7 | 144 | 1.317e-07 | 6.451e-06 |
| 96 | INNER EAR MORPHOGENESIS | 6 | 92 | 1.942e-07 | 9.414e-06 |
| 97 | EMBRYONIC MORPHOGENESIS | 11 | 539 | 2.012e-07 | 9.652e-06 |
| 98 | ANATOMICAL STRUCTURE FORMATION INVOLVED IN MORPHOGENESIS | 14 | 957 | 2.083e-07 | 9.888e-06 |
| 99 | TUBE MORPHOGENESIS | 9 | 323 | 2.214e-07 | 1.04e-05 |
| 100 | NEGATIVE REGULATION OF GROWTH | 8 | 236 | 2.521e-07 | 1.173e-05 |
| 101 | TUBE DEVELOPMENT | 11 | 552 | 2.553e-07 | 1.176e-05 |
| 102 | POSITIVE REGULATION OF CELL DIFFERENTIATION | 13 | 823 | 2.58e-07 | 1.177e-05 |
| 103 | REGULATION OF EPITHELIAL CELL MIGRATION | 7 | 166 | 3.47e-07 | 1.568e-05 |
| 104 | CARDIAC CHAMBER MORPHOGENESIS | 6 | 104 | 4.03e-07 | 1.79e-05 |
| 105 | POSITIVE REGULATION OF CELL COMMUNICATION | 17 | 1532 | 4.066e-07 | 1.79e-05 |
| 106 | NEGATIVE REGULATION OF CELL GROWTH | 7 | 170 | 4.078e-07 | 1.79e-05 |
| 107 | POSITIVE REGULATION OF CELLULAR RESPONSE TO TRANSFORMING GROWTH FACTOR BETA STIMULUS | 4 | 24 | 5.22e-07 | 2.228e-05 |
| 108 | FOREBRAIN DEVELOPMENT | 9 | 357 | 5.13e-07 | 2.228e-05 |
| 109 | POSITIVE REGULATION OF TRANSFORMING GROWTH FACTOR BETA RECEPTOR SIGNALING PATHWAY | 4 | 24 | 5.22e-07 | 2.228e-05 |
| 110 | BLOOD VESSEL MORPHOGENESIS | 9 | 364 | 6.033e-07 | 2.552e-05 |
| 111 | EAR MORPHOGENESIS | 6 | 112 | 6.248e-07 | 2.619e-05 |
| 112 | EMBRYO DEVELOPMENT | 13 | 894 | 6.608e-07 | 2.745e-05 |
| 113 | NEGATIVE REGULATION OF RESPONSE TO EXTERNAL STIMULUS | 8 | 274 | 7.813e-07 | 3.217e-05 |
| 114 | SENSORY ORGAN DEVELOPMENT | 10 | 493 | 8.18e-07 | 3.339e-05 |
| 115 | RESPONSE TO EXTERNAL STIMULUS | 18 | 1821 | 9.183e-07 | 3.716e-05 |
| 116 | EAR DEVELOPMENT | 7 | 195 | 1.027e-06 | 4.12e-05 |
| 117 | NERVE DEVELOPMENT | 5 | 68 | 1.193e-06 | 4.745e-05 |
| 118 | ANGIOGENESIS | 8 | 293 | 1.292e-06 | 5.053e-05 |
| 119 | POSITIVE REGULATION OF AXONOGENESIS | 5 | 69 | 1.284e-06 | 5.053e-05 |
| 120 | REGULATION OF TRANSMEMBRANE RECEPTOR PROTEIN SERINE THREONINE KINASE SIGNALING PATHWAY | 7 | 207 | 1.531e-06 | 5.937e-05 |
| 121 | REPRODUCTIVE SYSTEM DEVELOPMENT | 9 | 408 | 1.553e-06 | 5.974e-05 |
| 122 | BRANCHING MORPHOGENESIS OF AN EPITHELIAL TUBE | 6 | 131 | 1.568e-06 | 5.981e-05 |
| 123 | TISSUE MORPHOGENESIS | 10 | 533 | 1.654e-06 | 6.231e-05 |
| 124 | POSITIVE REGULATION OF CELL PROJECTION ORGANIZATION | 8 | 303 | 1.66e-06 | 6.231e-05 |
| 125 | SALIVARY GLAND DEVELOPMENT | 4 | 32 | 1.738e-06 | 6.469e-05 |
| 126 | REGULATION OF PROTEIN MODIFICATION PROCESS | 17 | 1710 | 1.889e-06 | 6.975e-05 |
| 127 | POSITIVE REGULATION OF CELLULAR COMPONENT ORGANIZATION | 14 | 1152 | 1.925e-06 | 7.053e-05 |
| 128 | ARTERY DEVELOPMENT | 5 | 75 | 1.947e-06 | 7.077e-05 |
| 129 | POSITIVE REGULATION OF RESPONSE TO STIMULUS | 18 | 1929 | 2.12e-06 | 7.645e-05 |
| 130 | DIENCEPHALON DEVELOPMENT | 5 | 77 | 2.219e-06 | 7.944e-05 |
| 131 | REGULATION OF ORGANELLE ORGANIZATION | 14 | 1178 | 2.502e-06 | 8.888e-05 |
| 132 | CELLULAR RESPONSE TO ENDOGENOUS STIMULUS | 13 | 1008 | 2.524e-06 | 8.895e-05 |
| 133 | RESPONSE TO WOUNDING | 10 | 563 | 2.699e-06 | 9.442e-05 |
| 134 | REGULATION OF CELLULAR RESPONSE TO GROWTH FACTOR STIMULUS | 7 | 229 | 2.994e-06 | 0.000104 |
| 135 | INTRACELLULAR SIGNAL TRANSDUCTION | 16 | 1572 | 3.07e-06 | 0.0001051 |
| 136 | RESPONSE TO OXYGEN CONTAINING COMPOUND | 15 | 1381 | 3.072e-06 | 0.0001051 |
| 137 | IMMUNE SYSTEM DEVELOPMENT | 10 | 582 | 3.625e-06 | 0.0001222 |
| 138 | PALATE DEVELOPMENT | 5 | 85 | 3.624e-06 | 0.0001222 |
| 139 | REGULATION OF CELLULAR COMPONENT SIZE | 8 | 337 | 3.654e-06 | 0.0001223 |
| 140 | REGULATION OF TRANSPORT | 17 | 1804 | 3.928e-06 | 0.0001305 |
| 141 | POSITIVE REGULATION OF EPITHELIAL CELL PROLIFERATION | 6 | 154 | 4.014e-06 | 0.0001325 |
| 142 | SINGLE ORGANISM CELL ADHESION | 9 | 459 | 4.07e-06 | 0.0001334 |
| 143 | REGULATION OF MESENCHYMAL CELL APOPTOTIC PROCESS | 3 | 12 | 4.254e-06 | 0.0001384 |
| 144 | REGULATION OF STEM CELL PROLIFERATION | 5 | 88 | 4.301e-06 | 0.000139 |
| 145 | MAMMARY GLAND MORPHOGENESIS | 4 | 40 | 4.345e-06 | 0.0001394 |
| 146 | REGULATION OF PHOSPHORUS METABOLIC PROCESS | 16 | 1618 | 4.46e-06 | 0.0001421 |
| 147 | MESONEPHROS DEVELOPMENT | 5 | 90 | 4.805e-06 | 0.0001521 |
| 148 | DEVELOPMENTAL PROCESS INVOLVED IN REPRODUCTION | 10 | 602 | 4.888e-06 | 0.0001537 |
| 149 | AUTONOMIC NERVOUS SYSTEM DEVELOPMENT | 4 | 42 | 5.3e-06 | 0.0001655 |
| 150 | POSITIVE REGULATION OF CELL MORPHOGENESIS INVOLVED IN DIFFERENTIATION | 6 | 162 | 5.375e-06 | 0.0001667 |
| 151 | CELLULAR RESPONSE TO ORGANIC SUBSTANCE | 17 | 1848 | 5.443e-06 | 0.0001677 |
| 152 | SEMAPHORIN PLEXIN SIGNALING PATHWAY INVOLVED IN NEURON PROJECTION GUIDANCE | 3 | 13 | 5.519e-06 | 0.0001679 |
| 153 | MESENCHYMAL CELL PROLIFERATION | 3 | 13 | 5.519e-06 | 0.0001679 |
| 154 | RESPONSE TO ENDOGENOUS STIMULUS | 15 | 1450 | 5.588e-06 | 0.0001688 |
| 155 | REGULATION OF INTRACELLULAR SIGNAL TRANSDUCTION | 16 | 1656 | 6.011e-06 | 0.0001805 |
| 156 | CENTRAL NERVOUS SYSTEM NEURON DIFFERENTIATION | 6 | 166 | 6.184e-06 | 0.0001844 |
| 157 | MORPHOGENESIS OF A BRANCHING STRUCTURE | 6 | 167 | 6.401e-06 | 0.0001897 |
| 158 | OUTFLOW TRACT SEPTUM MORPHOGENESIS | 3 | 14 | 7.011e-06 | 0.0002052 |
| 159 | EXOCRINE SYSTEM DEVELOPMENT | 4 | 45 | 7.013e-06 | 0.0002052 |
| 160 | REGULATION OF TRANSFORMING GROWTH FACTOR BETA RECEPTOR SIGNALING PATHWAY | 5 | 99 | 7.674e-06 | 0.0002204 |
| 161 | REGULATION OF CELLULAR RESPONSE TO TRANSFORMING GROWTH FACTOR BETA STIMULUS | 5 | 99 | 7.674e-06 | 0.0002204 |
| 162 | REPRODUCTION | 14 | 1297 | 7.636e-06 | 0.0002204 |
| 163 | EPITHELIUM DEVELOPMENT | 12 | 945 | 7.724e-06 | 0.0002205 |
| 164 | POSITIVE REGULATION OF TRANSMEMBRANE RECEPTOR PROTEIN SERINE THREONINE KINASE SIGNALING PATHWAY | 5 | 100 | 8.061e-06 | 0.0002287 |
| 165 | OTIC VESICLE DEVELOPMENT | 3 | 15 | 8.747e-06 | 0.0002394 |
| 166 | ECTODERMAL PLACODE DEVELOPMENT | 3 | 15 | 8.747e-06 | 0.0002394 |
| 167 | BLASTODERM SEGMENTATION | 3 | 15 | 8.747e-06 | 0.0002394 |
| 168 | MUSCLE CELL FATE COMMITMENT | 3 | 15 | 8.747e-06 | 0.0002394 |
| 169 | ECTODERMAL PLACODE MORPHOGENESIS | 3 | 15 | 8.747e-06 | 0.0002394 |
| 170 | ECTODERMAL PLACODE FORMATION | 3 | 15 | 8.747e-06 | 0.0002394 |
| 171 | POSITIVE REGULATION OF EPITHELIAL CELL MIGRATION | 5 | 103 | 9.315e-06 | 0.0002535 |
| 172 | REGULATION OF CHEMOTAXIS | 6 | 180 | 9.83e-06 | 0.0002659 |
| 173 | CARDIAC SEPTUM MORPHOGENESIS | 4 | 49 | 9.891e-06 | 0.000266 |
| 174 | ODONTOGENESIS | 5 | 105 | 1.023e-05 | 0.0002736 |
| 175 | CARDIAC VENTRICLE DEVELOPMENT | 5 | 106 | 1.072e-05 | 0.0002849 |
| 176 | POSITIVE REGULATION OF CELL PROLIFERATION | 11 | 814 | 1.102e-05 | 0.0002912 |
| 177 | PEPTIDYL TYROSINE MODIFICATION | 6 | 186 | 1.185e-05 | 0.0003115 |
| 178 | MORPHOGENESIS OF AN EPITHELIUM | 8 | 400 | 1.278e-05 | 0.000334 |
| 179 | NEGATIVE REGULATION OF KIDNEY DEVELOPMENT | 3 | 17 | 1.302e-05 | 0.0003366 |
| 180 | PARASYMPATHETIC NERVOUS SYSTEM DEVELOPMENT | 3 | 17 | 1.302e-05 | 0.0003366 |
| 181 | NEURON PROJECTION EXTENSION | 4 | 53 | 1.356e-05 | 0.0003486 |
| 182 | CELL DEATH | 12 | 1001 | 1.379e-05 | 0.0003526 |
| 183 | REGULATION OF OSTEOBLAST DIFFERENTIATION | 5 | 112 | 1.401e-05 | 0.0003562 |
| 184 | PROTEIN AUTOPHOSPHORYLATION | 6 | 192 | 1.419e-05 | 0.0003589 |
| 185 | LEUKOCYTE DIFFERENTIATION | 7 | 292 | 1.466e-05 | 0.0003668 |
| 186 | VENTRICULAR SEPTUM DEVELOPMENT | 4 | 54 | 1.461e-05 | 0.0003668 |
| 187 | REGULATION OF ENDOTHELIAL CELL MIGRATION | 5 | 114 | 1.527e-05 | 0.0003779 |
| 188 | REGULATION OF EMBRYONIC DEVELOPMENT | 5 | 114 | 1.527e-05 | 0.0003779 |
| 189 | NEGATIVE REGULATION OF EPITHELIAL CELL PROLIFERATION | 5 | 115 | 1.593e-05 | 0.0003921 |
| 190 | POSITIVE REGULATION OF MUSCLE TISSUE DEVELOPMENT | 4 | 56 | 1.69e-05 | 0.0004118 |
| 191 | OUTFLOW TRACT MORPHOGENESIS | 4 | 56 | 1.69e-05 | 0.0004118 |
| 192 | UROGENITAL SYSTEM DEVELOPMENT | 7 | 299 | 1.708e-05 | 0.0004139 |
| 193 | PATTERN SPECIFICATION PROCESS | 8 | 418 | 1.755e-05 | 0.000423 |
| 194 | MESODERM DEVELOPMENT | 5 | 118 | 1.804e-05 | 0.0004328 |
| 195 | THYMIC T CELL SELECTION | 3 | 19 | 1.848e-05 | 0.000441 |
| 196 | POSITIVE REGULATION OF NEURON DIFFERENTIATION | 7 | 306 | 1.982e-05 | 0.0004706 |
| 197 | REGULATION OF PROTEIN KINASE B SIGNALING | 5 | 121 | 2.037e-05 | 0.0004812 |
| 198 | NEGATIVE REGULATION OF CELL DEATH | 11 | 872 | 2.092e-05 | 0.0004917 |
| 199 | POSITIVE REGULATION OF INTRACELLULAR SIGNAL TRANSDUCTION | 11 | 876 | 2.183e-05 | 0.0005104 |
| 200 | MUSCLE STRUCTURE DEVELOPMENT | 8 | 432 | 2.222e-05 | 0.000517 |
| 201 | KIDNEY EPITHELIUM DEVELOPMENT | 5 | 125 | 2.384e-05 | 0.0005491 |
| 202 | POSITIVE REGULATION OF STEM CELL PROLIFERATION | 4 | 61 | 2.377e-05 | 0.0005491 |
| 203 | RESPONSE TO LIPID | 11 | 888 | 2.475e-05 | 0.0005673 |
| 204 | SYMPATHETIC NERVOUS SYSTEM DEVELOPMENT | 3 | 21 | 2.527e-05 | 0.0005764 |
| 205 | POSITIVE REGULATION OF PROTEIN LOCALIZATION TO NUCLEUS | 5 | 129 | 2.774e-05 | 0.0006297 |
| 206 | REGULATION OF PROTEIN LOCALIZATION TO NUCLEUS | 6 | 218 | 2.907e-05 | 0.0006566 |
| 207 | EYE DEVELOPMENT | 7 | 326 | 2.973e-05 | 0.0006683 |
| 208 | REGULATION OF CELL DEATH | 14 | 1472 | 3.183e-05 | 0.000712 |
| 209 | SKELETAL SYSTEM DEVELOPMENT | 8 | 455 | 3.217e-05 | 0.0007162 |
| 210 | RESPONSE TO ORGANIC CYCLIC COMPOUND | 11 | 917 | 3.326e-05 | 0.0007368 |
| 211 | CRANIAL NERVE MORPHOGENESIS | 3 | 23 | 3.352e-05 | 0.0007392 |
| 212 | CELL GROWTH | 5 | 135 | 3.451e-05 | 0.0007575 |
| 213 | REGULATION OF PHOSPHATIDYLINOSITOL 3 KINASE SIGNALING | 5 | 138 | 3.835e-05 | 0.0008338 |
| 214 | EMBRYONIC CAMERA TYPE EYE MORPHOGENESIS | 3 | 24 | 3.823e-05 | 0.0008338 |
| 215 | CELL CELL SIGNALING | 10 | 767 | 3.969e-05 | 0.0008551 |
| 216 | REGULATION OF CELL SHAPE | 5 | 139 | 3.969e-05 | 0.0008551 |
| 217 | WOUND HEALING | 8 | 470 | 4.048e-05 | 0.000868 |
| 218 | CENTRAL NERVOUS SYSTEM NEURON DEVELOPMENT | 4 | 70 | 4.101e-05 | 0.0008749 |
| 219 | POSITIVE REGULATION OF NEURON PROJECTION DEVELOPMENT | 6 | 232 | 4.118e-05 | 0.0008749 |
| 220 | REGULATION OF ANATOMICAL STRUCTURE SIZE | 8 | 472 | 4.171e-05 | 0.0008823 |
| 221 | REGULATION OF VASCULATURE DEVELOPMENT | 6 | 233 | 4.218e-05 | 0.000888 |
| 222 | CELL FATE SPECIFICATION | 4 | 71 | 4.337e-05 | 0.000905 |
| 223 | PHOSPHATIDYLINOSITOL 3 KINASE SIGNALING | 3 | 25 | 4.336e-05 | 0.000905 |
| 224 | NEGATIVE REGULATION OF NITROGEN COMPOUND METABOLIC PROCESS | 14 | 1517 | 4.438e-05 | 0.0009218 |
| 225 | RESPONSE TO INORGANIC SUBSTANCE | 8 | 479 | 4.628e-05 | 0.0009571 |
| 226 | POSITIVE REGULATION OF GROWTH | 6 | 238 | 4.747e-05 | 0.0009774 |
| 227 | NEGATIVE REGULATION OF EMBRYONIC DEVELOPMENT | 3 | 26 | 4.892e-05 | 0.001003 |
| 228 | REGULATION OF ORGAN MORPHOGENESIS | 6 | 242 | 5.208e-05 | 0.001063 |
| 229 | DIGESTIVE SYSTEM DEVELOPMENT | 5 | 148 | 5.355e-05 | 0.001088 |
| 230 | MOTOR NEURON AXON GUIDANCE | 3 | 27 | 5.493e-05 | 0.001106 |
| 231 | POSITIVE REGULATION OF MESENCHYMAL CELL PROLIFERATION | 3 | 27 | 5.493e-05 | 0.001106 |
| 232 | EPITHELIAL CELL DIFFERENTIATION | 8 | 495 | 5.831e-05 | 0.001169 |
| 233 | DEVELOPMENTAL CELL GROWTH | 4 | 77 | 5.967e-05 | 0.001192 |
| 234 | MAMMARY GLAND DUCT MORPHOGENESIS | 3 | 28 | 6.14e-05 | 0.001221 |
| 235 | ERBB SIGNALING PATHWAY | 4 | 79 | 6.598e-05 | 0.001306 |
| 236 | SENSORY PERCEPTION OF MECHANICAL STIMULUS | 5 | 155 | 6.67e-05 | 0.001315 |
| 237 | POSITIVE REGULATION OF MOLECULAR FUNCTION | 15 | 1791 | 6.81e-05 | 0.001337 |
| 238 | POSITIVE REGULATION OF DEVELOPMENTAL GROWTH | 5 | 156 | 6.877e-05 | 0.001339 |
| 239 | CELLULAR RESPONSE TO INORGANIC SUBSTANCE | 5 | 156 | 6.877e-05 | 0.001339 |
| 240 | POSITIVE REGULATION OF PROTEIN KINASE B SIGNALING | 4 | 81 | 7.277e-05 | 0.001411 |
| 241 | POSITIVE REGULATION OF CELL ADHESION | 7 | 376 | 7.327e-05 | 0.001415 |
| 242 | NEGATIVE REGULATION OF CELL COMMUNICATION | 12 | 1192 | 7.648e-05 | 0.001471 |
| 243 | REGULATION OF CELL CELL ADHESION | 7 | 380 | 7.829e-05 | 0.001499 |
| 244 | CELL PROLIFERATION | 9 | 672 | 8.25e-05 | 0.001573 |
| 245 | RESPONSE TO ABIOTIC STIMULUS | 11 | 1024 | 9.021e-05 | 0.001713 |
| 246 | ENZYME LINKED RECEPTOR PROTEIN SIGNALING PATHWAY | 9 | 689 | 9.98e-05 | 0.001883 |
| 247 | APPENDAGE DEVELOPMENT | 5 | 169 | 0.0001004 | 0.001883 |
| 248 | LIMB DEVELOPMENT | 5 | 169 | 0.0001004 | 0.001883 |
| 249 | EMBRYONIC EYE MORPHOGENESIS | 3 | 33 | 0.0001013 | 0.001892 |
| 250 | RESPONSE TO NITROGEN COMPOUND | 10 | 859 | 0.0001023 | 0.001904 |
| 251 | MUSCLE TISSUE DEVELOPMENT | 6 | 275 | 0.0001054 | 0.001954 |
| 252 | REGULATION OF MESENCHYMAL CELL PROLIFERATION | 3 | 34 | 0.0001109 | 0.002047 |
| 253 | REGULATION OF CELL SUBSTRATE ADHESION | 5 | 173 | 0.0001121 | 0.002061 |
| 254 | GLIOGENESIS | 5 | 175 | 0.0001183 | 0.002167 |
| 255 | EMBRYONIC CAMERA TYPE EYE DEVELOPMENT | 3 | 35 | 0.000121 | 0.002208 |
| 256 | REGULATION OF OSSIFICATION | 5 | 178 | 0.0001281 | 0.002328 |
| 257 | POSITIVE REGULATION OF AXON EXTENSION | 3 | 36 | 0.0001318 | 0.002376 |
| 258 | T CELL SELECTION | 3 | 36 | 0.0001318 | 0.002376 |
| 259 | CANONICAL WNT SIGNALING PATHWAY | 4 | 95 | 0.0001353 | 0.002431 |
| 260 | MYELOID LEUKOCYTE DIFFERENTIATION | 4 | 96 | 0.0001409 | 0.002512 |
| 261 | RESPONSE TO HORMONE | 10 | 893 | 0.0001407 | 0.002512 |
| 262 | CORONARY VASCULATURE DEVELOPMENT | 3 | 37 | 0.0001431 | 0.002522 |
| 263 | MYOBLAST DIFFERENTIATION | 3 | 37 | 0.0001431 | 0.002522 |
| 264 | AXON EXTENSION | 3 | 37 | 0.0001431 | 0.002522 |
| 265 | CELL JUNCTION ORGANIZATION | 5 | 185 | 0.0001534 | 0.002694 |
| 266 | ERBB2 SIGNALING PATHWAY | 3 | 39 | 0.0001677 | 0.002933 |
| 267 | MYELOID CELL DIFFERENTIATION | 5 | 189 | 0.0001695 | 0.002954 |
| 268 | RESPONSE TO DRUG | 7 | 431 | 0.0001709 | 0.002967 |
| 269 | REGULATION OF MUSCLE TISSUE DEVELOPMENT | 4 | 103 | 0.0001849 | 0.003187 |
| 270 | REGULATION OF MUSCLE ORGAN DEVELOPMENT | 4 | 103 | 0.0001849 | 0.003187 |
| 271 | POSITIVE REGULATION OF GENE EXPRESSION | 14 | 1733 | 0.0001858 | 0.00319 |
| 272 | AORTA DEVELOPMENT | 3 | 41 | 0.0001948 | 0.003332 |
| 273 | POSITIVE REGULATION OF TRANSPORT | 10 | 936 | 0.0002063 | 0.003503 |
| 274 | REGIONALIZATION | 6 | 311 | 0.0002058 | 0.003503 |
| 275 | CATECHOLAMINE METABOLIC PROCESS | 3 | 42 | 0.0002094 | 0.00353 |
| 276 | CATECHOL CONTAINING COMPOUND METABOLIC PROCESS | 3 | 42 | 0.0002094 | 0.00353 |
| 277 | PROTEIN PHOSPHORYLATION | 10 | 944 | 0.000221 | 0.003712 |
| 278 | REGULATION OF CELLULAR COMPONENT BIOGENESIS | 9 | 767 | 0.0002235 | 0.003728 |
| 279 | POSITIVE REGULATION OF PROTEIN MODIFICATION PROCESS | 11 | 1135 | 0.0002232 | 0.003728 |
| 280 | CELL FATE DETERMINATION | 3 | 43 | 0.0002246 | 0.003733 |
| 281 | REGULATION OF PROTEIN LOCALIZATION | 10 | 950 | 0.0002326 | 0.003851 |
| 282 | NEURON MIGRATION | 4 | 110 | 0.000238 | 0.003928 |
| 283 | CELL CELL ADHESION | 8 | 608 | 0.0002406 | 0.003955 |
| 284 | REGULATION OF KINASE ACTIVITY | 9 | 776 | 0.0002438 | 0.003994 |
| 285 | CELLULAR RESPONSE TO STRESS | 13 | 1565 | 0.0002534 | 0.004137 |
| 286 | THYMOCYTE AGGREGATION | 3 | 45 | 0.0002573 | 0.004157 |
| 287 | VENTRICULAR CARDIAC MUSCLE TISSUE DEVELOPMENT | 3 | 45 | 0.0002573 | 0.004157 |
| 288 | T CELL DIFFERENTIATION IN THYMUS | 3 | 45 | 0.0002573 | 0.004157 |
| 289 | REGULATION OF VESICLE MEDIATED TRANSPORT | 7 | 462 | 0.0002612 | 0.004205 |
| 290 | CELLULAR RESPONSE TO ORGANIC CYCLIC COMPOUND | 7 | 465 | 0.0002716 | 0.004358 |
| 291 | VENTRAL SPINAL CORD DEVELOPMENT | 3 | 46 | 0.0002747 | 0.004393 |
| 292 | POSITIVE REGULATION OF BIOSYNTHETIC PROCESS | 14 | 1805 | 0.0002842 | 0.004528 |
| 293 | THYMUS DEVELOPMENT | 3 | 47 | 0.0002929 | 0.004651 |
| 294 | SPECIFICATION OF SYMMETRY | 4 | 117 | 0.0003014 | 0.004753 |
| 295 | MAMMARY GLAND DEVELOPMENT | 4 | 117 | 0.0003014 | 0.004753 |
| 296 | EMBRYONIC SKELETAL SYSTEM DEVELOPMENT | 4 | 122 | 0.0003534 | 0.005556 |
| 297 | T CELL DIFFERENTIATION | 4 | 123 | 0.0003646 | 0.005712 |
| 298 | ARTERY MORPHOGENESIS | 3 | 51 | 0.0003732 | 0.005828 |
| 299 | INOSITOL LIPID MEDIATED SIGNALING | 4 | 124 | 0.000376 | 0.005851 |
| 300 | PROSTATE GLAND GROWTH | 2 | 11 | 0.000402 | 0.006193 |
| 301 | LYMPHOID PROGENITOR CELL DIFFERENTIATION | 2 | 11 | 0.000402 | 0.006193 |
| 302 | RESPONSE TO WATER DEPRIVATION | 2 | 11 | 0.000402 | 0.006193 |
| 303 | RESPONSE TO STEROID HORMONE | 7 | 497 | 0.0004057 | 0.006231 |
| 304 | TRANSMEMBRANE RECEPTOR PROTEIN TYROSINE KINASE SIGNALING PATHWAY | 7 | 498 | 0.0004106 | 0.006285 |
| 305 | REGULATION OF MORPHOGENESIS OF A BRANCHING STRUCTURE | 3 | 53 | 0.0004182 | 0.006339 |
| 306 | REGULATION OF MAPK CASCADE | 8 | 660 | 0.0004171 | 0.006339 |
| 307 | MAMMARY GLAND EPITHELIUM DEVELOPMENT | 3 | 53 | 0.0004182 | 0.006339 |
| 308 | CYTOSKELETON ORGANIZATION | 9 | 838 | 0.0004287 | 0.006476 |
| 309 | REGULATION OF CYTOSKELETON ORGANIZATION | 7 | 502 | 0.0004308 | 0.006487 |
| 310 | REGULATION OF LEUKOCYTE DIFFERENTIATION | 5 | 232 | 0.0004364 | 0.006535 |
| 311 | REGULATION OF REPRODUCTIVE PROCESS | 4 | 129 | 0.0004368 | 0.006535 |
| 312 | CELL DIFFERENTIATION IN SPINAL CORD | 3 | 54 | 0.000442 | 0.006591 |
| 313 | CELLULAR RESPONSE TO NITROGEN COMPOUND | 7 | 505 | 0.0004464 | 0.006636 |
| 314 | POSITIVE REGULATION OF CELLULAR PROTEIN LOCALIZATION | 6 | 360 | 0.0004497 | 0.006663 |
| 315 | POSITIVE REGULATION OF PHOSPHATE METABOLIC PROCESS | 10 | 1036 | 0.0004636 | 0.006805 |
| 316 | POSITIVE REGULATION OF PHOSPHORUS METABOLIC PROCESS | 10 | 1036 | 0.0004636 | 0.006805 |
| 317 | RESPONSE TO ALCOHOL | 6 | 362 | 0.000463 | 0.006805 |
| 318 | REGULATION OF KIDNEY DEVELOPMENT | 3 | 55 | 0.0004666 | 0.006826 |
| 319 | ENDOCYTOSIS | 7 | 509 | 0.000468 | 0.006826 |
| 320 | NEURON PROJECTION EXTENSION INVOLVED IN NEURON PROJECTION GUIDANCE | 2 | 12 | 0.0004815 | 0.006958 |
| 321 | AXON EXTENSION INVOLVED IN AXON GUIDANCE | 2 | 12 | 0.0004815 | 0.006958 |
| 322 | MUSCLE CELL DIFFERENTIATION | 5 | 237 | 0.0004809 | 0.006958 |
| 323 | EPITHELIAL TO MESENCHYMAL TRANSITION | 3 | 56 | 0.000492 | 0.007088 |
| 324 | ENDOTHELIAL CELL MIGRATION | 3 | 57 | 0.0005183 | 0.007444 |
| 325 | GLIAL CELL DIFFERENTIATION | 4 | 136 | 0.0005332 | 0.007634 |
| 326 | POSITIVE REGULATION OF CELLULAR AMINE METABOLIC PROCESS | 2 | 13 | 0.000568 | 0.008009 |
| 327 | NEGATIVE REGULATION OF CELL CELL ADHESION | 4 | 138 | 0.0005634 | 0.008009 |
| 328 | REGULATION OF CELL PROLIFERATION INVOLVED IN KIDNEY DEVELOPMENT | 2 | 13 | 0.000568 | 0.008009 |
| 329 | PLACENTA DEVELOPMENT | 4 | 138 | 0.0005634 | 0.008009 |
| 330 | GANGLION DEVELOPMENT | 2 | 13 | 0.000568 | 0.008009 |
| 331 | CARDIAC MUSCLE TISSUE DEVELOPMENT | 4 | 140 | 0.0005947 | 0.00836 |
| 332 | STEM CELL PROLIFERATION | 3 | 60 | 0.0006027 | 0.008421 |
| 333 | OLIGODENDROCYTE DIFFERENTIATION | 3 | 60 | 0.0006027 | 0.008421 |
| 334 | OSSIFICATION | 5 | 251 | 0.0006239 | 0.008692 |
| 335 | EMBRYONIC DIGIT MORPHOGENESIS | 3 | 61 | 0.0006326 | 0.008787 |
| 336 | RESPONSE TO TRANSFORMING GROWTH FACTOR BETA | 4 | 144 | 0.0006611 | 0.00908 |
| 337 | CARDIAC VENTRICLE MORPHOGENESIS | 3 | 62 | 0.0006635 | 0.00908 |
| 338 | METANEPHRIC MESENCHYME DEVELOPMENT | 2 | 14 | 0.0006615 | 0.00908 |
| 339 | POSITIVE REGULATION OF PHOSPHATIDYLINOSITOL 3 KINASE SIGNALING | 3 | 62 | 0.0006635 | 0.00908 |
| 340 | EMBRYONIC HEART TUBE MORPHOGENESIS | 3 | 62 | 0.0006635 | 0.00908 |
| 341 | NEGATIVE REGULATION OF PHOSPHORUS METABOLIC PROCESS | 7 | 541 | 0.0006719 | 0.009115 |
| 342 | LEUKOCYTE CELL CELL ADHESION | 5 | 255 | 0.0006701 | 0.009115 |
| 343 | NEGATIVE REGULATION OF PHOSPHATE METABOLIC PROCESS | 7 | 541 | 0.0006719 | 0.009115 |
| 344 | NEGATIVE REGULATION OF PROTEIN METABOLIC PROCESS | 10 | 1087 | 0.0006748 | 0.009128 |
| 345 | RESPONSE TO IONIZING RADIATION | 4 | 145 | 0.0006785 | 0.00915 |
| 346 | POSITIVE REGULATION OF CELL GROWTH | 4 | 148 | 0.0007325 | 0.009823 |
| 347 | MALE SEX DIFFERENTIATION | 4 | 148 | 0.0007325 | 0.009823 |
| Num | GO | Overlap | Size | P Value | Adj. P Value |
|---|---|---|---|---|---|
| 1 | SEMAPHORIN RECEPTOR BINDING | 6 | 22 | 2.355e-11 | 2.187e-08 |
| 2 | CHEMOREPELLENT ACTIVITY | 5 | 27 | 1.006e-08 | 3.159e-06 |
| 3 | PROTEIN DOMAIN SPECIFIC BINDING | 13 | 624 | 1.02e-08 | 3.159e-06 |
| 4 | RECEPTOR BINDING | 17 | 1476 | 2.395e-07 | 5.562e-05 |
| 5 | PROTEIN TYROSINE KINASE ACTIVITY | 7 | 176 | 5.155e-07 | 9.578e-05 |
| 6 | TRANSMEMBRANE RECEPTOR PROTEIN KINASE ACTIVITY | 5 | 81 | 2.854e-06 | 0.0004419 |
| 7 | PROTEIN KINASE ACTIVITY | 10 | 640 | 8.366e-06 | 0.001016 |
| 8 | NEUROPILIN BINDING | 3 | 15 | 8.747e-06 | 0.001016 |
| 9 | GLYCOSAMINOGLYCAN BINDING | 6 | 205 | 2.057e-05 | 0.002049 |
| 10 | GROWTH FACTOR BINDING | 5 | 123 | 2.205e-05 | 0.002049 |
| 11 | TRANSMEMBRANE RECEPTOR PROTEIN TYROSINE KINASE ACTIVITY | 4 | 64 | 2.877e-05 | 0.00243 |
| 12 | KINASE ACTIVITY | 10 | 842 | 8.67e-05 | 0.006712 |
| Num | GO | Overlap | Size | P Value | Adj. P Value |
|---|---|---|---|---|---|
| 1 | ENDOCYTIC VESICLE | 7 | 256 | 6.232e-06 | 0.001331 |
| 2 | NEURON PROJECTION | 12 | 942 | 7.479e-06 | 0.001331 |
| 3 | PLASMA MEMBRANE REGION | 12 | 929 | 6.494e-06 | 0.001331 |
| 4 | MEMBRANE REGION | 13 | 1134 | 9.116e-06 | 0.001331 |
| 5 | CELL PROJECTION | 16 | 1786 | 1.568e-05 | 0.001831 |
| 6 | SIDE OF MEMBRANE | 8 | 428 | 2.079e-05 | 0.002024 |
| 7 | INTRACELLULAR VESICLE | 13 | 1259 | 2.771e-05 | 0.002312 |
| 8 | CELL SURFACE | 10 | 757 | 3.552e-05 | 0.002593 |
| 9 | CELL LEADING EDGE | 7 | 350 | 4.668e-05 | 0.003029 |
| 10 | APICAL PART OF CELL | 7 | 361 | 5.674e-05 | 0.003314 |
| 11 | RUFFLE | 5 | 156 | 6.877e-05 | 0.003651 |
| 12 | NEURON PART | 12 | 1265 | 0.0001346 | 0.006101 |
| 13 | AXON | 7 | 418 | 0.0001415 | 0.006101 |
| 14 | APICAL PLASMA MEMBRANE | 6 | 292 | 0.0001463 | 0.006101 |
| 15 | ACTIN CYTOSKELETON | 7 | 444 | 0.000205 | 0.007483 |
| 16 | CYTOSKELETON | 15 | 1967 | 0.0001958 | 0.007483 |
| 17 | CELL PROJECTION PART | 10 | 946 | 0.0002248 | 0.007722 |
| 18 | RECEPTOR COMPLEX | 6 | 327 | 0.0002695 | 0.008745 |
Over-represented Pathway
| Num | Pathway | Pathview | Overlap | Size | P Value | Adj. P Value |
|---|---|---|---|---|---|---|
| 1 | Adherens_junction_hsa04520 | 4 | 72 | 4.583e-05 | 0.001789 | |
| 2 | ErbB_signaling_pathway_hsa04012 | 4 | 85 | 8.784e-05 | 0.001789 | |
| 3 | Tight_junction_hsa04530 | 5 | 170 | 0.0001032 | 0.001789 | |
| 4 | Rap1_signaling_pathway_hsa04015 | 4 | 206 | 0.002473 | 0.02407 | |
| 5 | Regulation_of_actin_cytoskeleton_hsa04810 | 4 | 208 | 0.002561 | 0.02407 | |
| 6 | PI3K_Akt_signaling_pathway_hsa04151 | 5 | 352 | 0.002777 | 0.02407 | |
| 7 | Endocytosis_hsa04144 | 4 | 244 | 0.004529 | 0.03364 | |
| 8 | Cell_adhesion_molecules_.CAMs._hsa04514 | 3 | 145 | 0.007436 | 0.04833 | |
| 9 | MAPK_signaling_pathway_hsa04010 | 4 | 295 | 0.008769 | 0.05067 | |
| 10 | VEGF_signaling_pathway_hsa04370 | 2 | 59 | 0.01149 | 0.05976 | |
| 11 | Focal_adhesion_hsa04510 | 3 | 199 | 0.01743 | 0.08238 | |
| 12 | Signaling_pathways_regulating_pluripotency_of_stem_cells_hsa04550 | 2 | 139 | 0.05607 | 0.243 | |
| 13 | Phospholipase_D_signaling_pathway_hsa04072 | 2 | 146 | 0.06114 | 0.2446 | |
| 14 | Hippo_signaling_pathway_hsa04390 | 2 | 154 | 0.06712 | 0.2493 | |
| 15 | Calcium_signaling_pathway_hsa04020 | 2 | 182 | 0.08944 | 0.3101 | |
| 16 | Neuroactive_ligand_receptor_interaction_hsa04080 | 2 | 278 | 0.1778 | 0.5136 |
lncRNA-mediated sponge
| Num | lncRNA | miRNAs | miRNAs count | Gene | Sponge regulatory network | lncRNA log2FC | lncRNA pvalue | Gene log2FC | Gene pvalue | lncRNA-gene Pearson correlation |
|---|---|---|---|---|---|---|---|---|---|---|
| 1 | RP11-253E3.3 | hsa-miR-141-3p;hsa-miR-16-1-3p;hsa-miR-194-5p;hsa-miR-197-3p;hsa-miR-200a-3p;hsa-miR-28-5p;hsa-miR-301a-3p;hsa-miR-30b-5p;hsa-miR-30c-5p;hsa-miR-30d-5p;hsa-miR-30e-5p;hsa-miR-320a;hsa-miR-320b;hsa-miR-3607-3p | 14 | NRP1 | Sponge network | -0.01 | 0.98061 | -0.612 | 0.02915 | 0.488 |
| 2 | GAS6-AS2 | hsa-miR-130b-3p;hsa-miR-141-3p;hsa-miR-148a-3p;hsa-miR-16-1-3p;hsa-miR-16-2-3p;hsa-miR-16-5p;hsa-miR-186-5p;hsa-miR-194-5p;hsa-miR-197-3p;hsa-miR-200a-3p;hsa-miR-301a-3p;hsa-miR-421;hsa-miR-429;hsa-miR-590-5p;hsa-miR-664a-3p;hsa-miR-7-1-3p | 16 | NRP1 | Sponge network | -2.655 | 0 | -0.612 | 0.02915 | 0.456 |
| 3 | LINC00702 | hsa-miR-130b-3p;hsa-miR-141-3p;hsa-miR-148a-3p;hsa-miR-16-1-3p;hsa-miR-16-2-3p;hsa-miR-16-5p;hsa-miR-186-5p;hsa-miR-194-5p;hsa-miR-197-3p;hsa-miR-200a-3p;hsa-miR-301a-3p;hsa-miR-30b-5p;hsa-miR-30c-5p;hsa-miR-30d-5p;hsa-miR-30e-5p;hsa-miR-320a;hsa-miR-320b;hsa-miR-330-5p;hsa-miR-361-5p;hsa-miR-421;hsa-miR-454-3p;hsa-miR-582-5p;hsa-miR-590-3p;hsa-miR-590-5p;hsa-miR-664a-3p;hsa-miR-7-1-3p | 26 | NRP1 | Sponge network | -2.704 | 0 | -0.612 | 0.02915 | 0.45 |
| 4 | RP11-175K6.1 | hsa-miR-130b-3p;hsa-miR-148a-3p;hsa-miR-16-1-3p;hsa-miR-16-2-3p;hsa-miR-16-5p;hsa-miR-186-5p;hsa-miR-194-5p;hsa-miR-197-3p;hsa-miR-301a-3p;hsa-miR-320a;hsa-miR-320b;hsa-miR-330-5p;hsa-miR-421;hsa-miR-590-5p | 14 | NRP1 | Sponge network | -2.386 | 0 | -0.612 | 0.02915 | 0.449 |
| 5 | VIM-AS1 | hsa-miR-130b-3p;hsa-miR-141-3p;hsa-miR-16-1-3p;hsa-miR-186-5p;hsa-miR-194-5p;hsa-miR-197-3p;hsa-miR-200a-3p;hsa-miR-28-5p;hsa-miR-301a-3p;hsa-miR-320a;hsa-miR-320b;hsa-miR-421;hsa-miR-7-1-3p;hsa-miR-944 | 14 | NRP1 | Sponge network | -1.424 | 0.00627 | -0.612 | 0.02915 | 0.447 |
| 6 | RASSF8-AS1 | hsa-miR-130b-3p;hsa-miR-141-3p;hsa-miR-16-1-3p;hsa-miR-16-5p;hsa-miR-186-5p;hsa-miR-194-5p;hsa-miR-197-3p;hsa-miR-200a-3p;hsa-miR-30b-5p;hsa-miR-30c-5p;hsa-miR-30d-5p;hsa-miR-30e-5p;hsa-miR-320a;hsa-miR-320b;hsa-miR-3607-3p;hsa-miR-361-5p;hsa-miR-429;hsa-miR-582-5p;hsa-miR-590-3p;hsa-miR-664a-3p;hsa-miR-7-1-3p;hsa-miR-944 | 22 | NRP1 | Sponge network | -0.877 | 0.00508 | -0.612 | 0.02915 | 0.435 |
| 7 | RP11-536K7.3 | hsa-miR-130b-3p;hsa-miR-141-3p;hsa-miR-16-2-3p;hsa-miR-16-5p;hsa-miR-186-5p;hsa-miR-194-5p;hsa-miR-197-3p;hsa-miR-200a-3p;hsa-miR-301a-3p;hsa-miR-30b-5p;hsa-miR-30c-5p;hsa-miR-30d-5p;hsa-miR-30e-5p;hsa-miR-330-5p;hsa-miR-582-5p;hsa-miR-590-3p | 16 | NRP1 | Sponge network | -0.673 | 0.17143 | -0.612 | 0.02915 | 0.426 |
| 8 | RP11-389C8.2 | hsa-miR-130b-3p;hsa-miR-16-1-3p;hsa-miR-16-2-3p;hsa-miR-16-5p;hsa-miR-186-5p;hsa-miR-197-3p;hsa-miR-301a-3p;hsa-miR-421;hsa-miR-590-3p;hsa-miR-7-1-3p | 10 | NRP1 | Sponge network | -0.61 | 0.01261 | -0.612 | 0.02915 | 0.425 |
| 9 | LINC00565 | hsa-miR-130b-3p;hsa-miR-16-1-3p;hsa-miR-16-5p;hsa-miR-186-5p;hsa-miR-197-3p;hsa-miR-301a-3p;hsa-miR-330-5p;hsa-miR-3607-3p;hsa-miR-664a-3p;hsa-miR-944 | 10 | NRP1 | Sponge network | -1.493 | 0.05998 | -0.612 | 0.02915 | 0.424 |
| 10 | NR2F1-AS1 | hsa-miR-130b-3p;hsa-miR-141-3p;hsa-miR-148a-3p;hsa-miR-16-1-3p;hsa-miR-16-2-3p;hsa-miR-16-5p;hsa-miR-186-5p;hsa-miR-194-5p;hsa-miR-197-3p;hsa-miR-200a-3p;hsa-miR-28-5p;hsa-miR-301a-3p;hsa-miR-320a;hsa-miR-320b;hsa-miR-330-5p;hsa-miR-3607-3p;hsa-miR-361-5p;hsa-miR-421;hsa-miR-429;hsa-miR-454-3p;hsa-miR-582-5p;hsa-miR-590-3p;hsa-miR-664a-3p;hsa-miR-7-1-3p;hsa-miR-944 | 25 | NRP1 | Sponge network | -1.881 | 0 | -0.612 | 0.02915 | 0.423 |
| 11 | FAM225B | hsa-miR-141-3p;hsa-miR-200a-3p;hsa-miR-28-5p;hsa-miR-30b-5p;hsa-miR-30c-5p;hsa-miR-30d-5p;hsa-miR-30e-5p;hsa-miR-320a;hsa-miR-3607-3p;hsa-miR-582-5p;hsa-miR-664a-3p | 11 | NRP1 | Sponge network | 0.864 | 0.07672 | -0.612 | 0.02915 | 0.422 |
| 12 | RP11-166D19.1 | hsa-miR-130b-3p;hsa-miR-141-3p;hsa-miR-148a-3p;hsa-miR-16-1-3p;hsa-miR-16-2-3p;hsa-miR-16-5p;hsa-miR-186-5p;hsa-miR-194-5p;hsa-miR-197-3p;hsa-miR-200a-3p;hsa-miR-301a-3p;hsa-miR-320a;hsa-miR-320b;hsa-miR-330-5p;hsa-miR-335-5p;hsa-miR-3607-3p;hsa-miR-361-5p;hsa-miR-421;hsa-miR-429;hsa-miR-454-3p;hsa-miR-590-3p;hsa-miR-590-5p;hsa-miR-664a-3p;hsa-miR-7-1-3p;hsa-miR-944 | 25 | NRP1 | Sponge network | -3.855 | 0 | -0.612 | 0.02915 | 0.42 |
| 13 | MAGI2-AS3 | hsa-miR-130b-3p;hsa-miR-141-3p;hsa-miR-16-1-3p;hsa-miR-16-2-3p;hsa-miR-16-5p;hsa-miR-186-5p;hsa-miR-194-5p;hsa-miR-197-3p;hsa-miR-200a-3p;hsa-miR-301a-3p;hsa-miR-30b-5p;hsa-miR-30c-5p;hsa-miR-30d-5p;hsa-miR-30e-5p;hsa-miR-320a;hsa-miR-320b;hsa-miR-324-5p;hsa-miR-330-5p;hsa-miR-335-5p;hsa-miR-3607-3p;hsa-miR-361-5p;hsa-miR-421;hsa-miR-429;hsa-miR-454-3p;hsa-miR-582-5p;hsa-miR-590-3p;hsa-miR-664a-3p;hsa-miR-7-1-3p;hsa-miR-944 | 29 | NRP1 | Sponge network | -2.414 | 0 | -0.612 | 0.02915 | 0.419 |
| 14 | RP11-359E10.1 | hsa-miR-130b-3p;hsa-miR-16-1-3p;hsa-miR-16-2-3p;hsa-miR-16-5p;hsa-miR-186-5p;hsa-miR-194-5p;hsa-miR-301a-3p;hsa-miR-330-5p;hsa-miR-361-5p;hsa-miR-582-5p;hsa-miR-7-1-3p | 11 | NRP1 | Sponge network | -1.216 | 0.0438 | -0.612 | 0.02915 | 0.417 |
| 15 | RP11-356I2.4 | hsa-miR-130b-3p;hsa-miR-141-3p;hsa-miR-16-1-3p;hsa-miR-186-5p;hsa-miR-194-5p;hsa-miR-200a-3p;hsa-miR-28-5p;hsa-miR-301a-3p;hsa-miR-3607-3p;hsa-miR-664a-3p | 10 | NRP1 | Sponge network | -0.68 | 0.02565 | -0.612 | 0.02915 | 0.405 |
| 16 | RP11-145A3.1 | hsa-miR-130b-3p;hsa-miR-16-1-3p;hsa-miR-16-2-3p;hsa-miR-186-5p;hsa-miR-197-3p;hsa-miR-28-5p;hsa-miR-301a-3p;hsa-miR-590-3p;hsa-miR-590-5p;hsa-miR-944 | 10 | NRP1 | Sponge network | 1.041 | 0.23373 | -0.612 | 0.02915 | 0.402 |
| 17 | PCED1B-AS1 | hsa-miR-130b-3p;hsa-miR-141-3p;hsa-miR-16-1-3p;hsa-miR-16-2-3p;hsa-miR-186-5p;hsa-miR-194-5p;hsa-miR-197-3p;hsa-miR-200a-3p;hsa-miR-301a-3p;hsa-miR-3607-3p;hsa-miR-429;hsa-miR-7-1-3p | 12 | NRP1 | Sponge network | -0.575 | 0.17488 | -0.612 | 0.02915 | 0.397 |
| 18 | RP11-532F6.3 | hsa-miR-130b-3p;hsa-miR-16-1-3p;hsa-miR-16-2-3p;hsa-miR-16-5p;hsa-miR-186-5p;hsa-miR-194-5p;hsa-miR-197-3p;hsa-miR-301a-3p;hsa-miR-330-5p;hsa-miR-590-3p | 10 | NRP1 | Sponge network | -1.772 | 1.0E-5 | -0.612 | 0.02915 | 0.389 |
| 19 | APCDD1L-AS1 | hsa-miR-130b-3p;hsa-miR-141-3p;hsa-miR-148a-3p;hsa-miR-16-1-3p;hsa-miR-16-2-3p;hsa-miR-16-5p;hsa-miR-186-5p;hsa-miR-194-5p;hsa-miR-197-3p;hsa-miR-200a-3p;hsa-miR-28-5p;hsa-miR-301a-3p;hsa-miR-320a;hsa-miR-320b;hsa-miR-3607-3p;hsa-miR-664a-3p;hsa-miR-7-1-3p | 17 | NRP1 | Sponge network | -2.022 | 0.00702 | -0.612 | 0.02915 | 0.381 |
| 20 | LINC00578 | hsa-miR-130b-3p;hsa-miR-16-1-3p;hsa-miR-16-2-3p;hsa-miR-16-5p;hsa-miR-186-5p;hsa-miR-194-5p;hsa-miR-197-3p;hsa-miR-301a-3p;hsa-miR-320a;hsa-miR-320b;hsa-miR-324-5p;hsa-miR-664a-3p | 12 | NRP1 | Sponge network | -1.091 | 0.13719 | -0.612 | 0.02915 | 0.377 |
| 21 | AC002480.3 | hsa-miR-130b-3p;hsa-miR-141-3p;hsa-miR-16-1-3p;hsa-miR-194-5p;hsa-miR-197-3p;hsa-miR-200a-3p;hsa-miR-28-5p;hsa-miR-301a-3p;hsa-miR-320a;hsa-miR-320b;hsa-miR-324-5p;hsa-miR-454-3p;hsa-miR-664a-3p | 13 | NRP1 | Sponge network | -1.522 | 0.03484 | -0.612 | 0.02915 | 0.376 |
| 22 | LINC00242 | hsa-miR-130b-3p;hsa-miR-141-3p;hsa-miR-16-1-3p;hsa-miR-16-5p;hsa-miR-186-5p;hsa-miR-200a-3p;hsa-miR-28-5p;hsa-miR-301a-3p;hsa-miR-324-5p;hsa-miR-330-5p;hsa-miR-421;hsa-miR-590-5p | 12 | NRP1 | Sponge network | -0.58 | 0.1728 | -0.612 | 0.02915 | 0.368 |
| 23 | RP11-367G6.3 | hsa-miR-130b-3p;hsa-miR-141-3p;hsa-miR-16-1-3p;hsa-miR-186-5p;hsa-miR-194-5p;hsa-miR-200a-3p;hsa-miR-28-5p;hsa-miR-301a-3p;hsa-miR-3607-3p;hsa-miR-421;hsa-miR-944 | 11 | NRP1 | Sponge network | -1.318 | 0.14472 | -0.612 | 0.02915 | 0.364 |
| 24 | RP11-284N8.3 | hsa-miR-130b-3p;hsa-miR-141-3p;hsa-miR-16-1-3p;hsa-miR-16-2-3p;hsa-miR-186-5p;hsa-miR-197-3p;hsa-miR-200a-3p;hsa-miR-301a-3p;hsa-miR-320a;hsa-miR-320b;hsa-miR-582-5p;hsa-miR-590-5p;hsa-miR-7-1-3p;hsa-miR-944 | 14 | NRP1 | Sponge network | -1.414 | 0.007 | -0.612 | 0.02915 | 0.363 |
| 25 | AC020571.3 | hsa-miR-130b-3p;hsa-miR-16-1-3p;hsa-miR-16-2-3p;hsa-miR-16-5p;hsa-miR-186-5p;hsa-miR-197-3p;hsa-miR-28-5p;hsa-miR-301a-3p;hsa-miR-324-5p;hsa-miR-3607-3p;hsa-miR-582-5p;hsa-miR-944 | 12 | NRP1 | Sponge network | -0.862 | 0.18422 | -0.612 | 0.02915 | 0.357 |
| 26 | DNM3OS | hsa-miR-130b-3p;hsa-miR-141-3p;hsa-miR-148a-3p;hsa-miR-16-1-3p;hsa-miR-16-2-3p;hsa-miR-16-5p;hsa-miR-186-5p;hsa-miR-194-5p;hsa-miR-200a-3p;hsa-miR-301a-3p;hsa-miR-320a;hsa-miR-320b;hsa-miR-429;hsa-miR-454-3p;hsa-miR-590-3p;hsa-miR-590-5p;hsa-miR-664a-3p;hsa-miR-7-1-3p;hsa-miR-944 | 19 | NRP1 | Sponge network | -2.298 | 1.0E-5 | -0.612 | 0.02915 | 0.354 |
| 27 | AC011526.1 | hsa-miR-16-1-3p;hsa-miR-16-2-3p;hsa-miR-16-5p;hsa-miR-200a-3p;hsa-miR-320a;hsa-miR-320b;hsa-miR-330-5p;hsa-miR-361-5p;hsa-miR-421;hsa-miR-590-3p | 10 | NRP1 | Sponge network | -1.209 | 1.0E-5 | -0.612 | 0.02915 | 0.349 |
| 28 | LINC00163 | hsa-miR-130b-3p;hsa-miR-148a-3p;hsa-miR-16-1-3p;hsa-miR-16-5p;hsa-miR-186-5p;hsa-miR-194-5p;hsa-miR-197-3p;hsa-miR-28-5p;hsa-miR-301a-3p;hsa-miR-324-5p;hsa-miR-330-5p;hsa-miR-664a-3p | 12 | NRP1 | Sponge network | -4.312 | 0.00014 | -0.612 | 0.02915 | 0.348 |
| 29 | RP11-325F22.2 | hsa-miR-130b-3p;hsa-miR-141-3p;hsa-miR-16-1-3p;hsa-miR-16-5p;hsa-miR-194-5p;hsa-miR-197-3p;hsa-miR-200a-3p;hsa-miR-301a-3p;hsa-miR-3607-3p;hsa-miR-421 | 10 | NRP1 | Sponge network | -1.801 | 0.01297 | -0.612 | 0.02915 | 0.344 |
| 30 | LINC00327 | hsa-miR-130b-3p;hsa-miR-148a-3p;hsa-miR-16-1-3p;hsa-miR-16-2-3p;hsa-miR-16-5p;hsa-miR-186-5p;hsa-miR-194-5p;hsa-miR-197-3p;hsa-miR-28-5p;hsa-miR-301a-3p;hsa-miR-30b-5p;hsa-miR-30c-5p;hsa-miR-30d-5p;hsa-miR-30e-5p;hsa-miR-324-5p;hsa-miR-330-5p;hsa-miR-3607-3p;hsa-miR-361-5p;hsa-miR-421;hsa-miR-590-3p;hsa-miR-664a-3p;hsa-miR-944 | 22 | NRP1 | Sponge network | -1.951 | 0.01135 | -0.612 | 0.02915 | 0.341 |
| 31 | RP11-35G9.5 | hsa-miR-130b-3p;hsa-miR-141-3p;hsa-miR-16-1-3p;hsa-miR-16-5p;hsa-miR-186-5p;hsa-miR-194-5p;hsa-miR-200a-3p;hsa-miR-28-5p;hsa-miR-301a-3p;hsa-miR-330-5p;hsa-miR-3607-3p;hsa-miR-421;hsa-miR-454-3p | 13 | NRP1 | Sponge network | -0.537 | 0.0574 | -0.612 | 0.02915 | 0.341 |
| 32 | RP11-399O19.9 | hsa-miR-130b-3p;hsa-miR-16-1-3p;hsa-miR-16-2-3p;hsa-miR-16-5p;hsa-miR-186-5p;hsa-miR-194-5p;hsa-miR-197-3p;hsa-miR-301a-3p;hsa-miR-429;hsa-miR-7-1-3p | 10 | NRP1 | Sponge network | -0.911 | 0.02612 | -0.612 | 0.02915 | 0.335 |
| 33 | C4A-AS1 | hsa-miR-130b-3p;hsa-miR-16-5p;hsa-miR-186-5p;hsa-miR-194-5p;hsa-miR-197-3p;hsa-miR-301a-3p;hsa-miR-330-5p;hsa-miR-3607-3p;hsa-miR-361-5p;hsa-miR-590-5p | 10 | NRP1 | Sponge network | -1.76 | 0.00265 | -0.612 | 0.02915 | 0.333 |
| 34 | RP6-91H8.3 | hsa-miR-141-3p;hsa-miR-194-5p;hsa-miR-200a-3p;hsa-miR-28-5p;hsa-miR-30b-5p;hsa-miR-30c-5p;hsa-miR-30d-5p;hsa-miR-30e-5p;hsa-miR-320a;hsa-miR-361-5p | 10 | NRP1 | Sponge network | 0.534 | 0.59239 | -0.612 | 0.02915 | 0.327 |
| 35 | LINC01010 | hsa-miR-194-5p;hsa-miR-200a-3p;hsa-miR-28-5p;hsa-miR-301a-3p;hsa-miR-30b-5p;hsa-miR-30c-5p;hsa-miR-30d-5p;hsa-miR-30e-5p;hsa-miR-429;hsa-miR-582-5p;hsa-miR-664a-3p | 11 | NRP1 | Sponge network | 0.747 | 0.44797 | -0.612 | 0.02915 | 0.327 |
| 36 | RP11-356J5.12 | hsa-miR-130b-3p;hsa-miR-141-3p;hsa-miR-148a-3p;hsa-miR-16-1-3p;hsa-miR-16-2-3p;hsa-miR-16-5p;hsa-miR-186-5p;hsa-miR-194-5p;hsa-miR-197-3p;hsa-miR-200a-3p;hsa-miR-301a-3p;hsa-miR-320a;hsa-miR-320b;hsa-miR-324-5p;hsa-miR-330-5p;hsa-miR-335-5p;hsa-miR-3607-3p;hsa-miR-361-5p;hsa-miR-590-3p;hsa-miR-590-5p;hsa-miR-7-1-3p | 21 | NRP1 | Sponge network | -2.015 | 0 | -0.612 | 0.02915 | 0.322 |
| 37 | RP11-1024P17.1 | hsa-miR-130b-3p;hsa-miR-141-3p;hsa-miR-16-1-3p;hsa-miR-16-2-3p;hsa-miR-16-5p;hsa-miR-186-5p;hsa-miR-197-3p;hsa-miR-200a-3p;hsa-miR-301a-3p;hsa-miR-320a;hsa-miR-320b;hsa-miR-324-5p;hsa-miR-429;hsa-miR-590-3p | 14 | NRP1 | Sponge network | -1.552 | 0 | -0.612 | 0.02915 | 0.312 |
| 38 | MIR143HG | hsa-miR-130b-3p;hsa-miR-141-3p;hsa-miR-148a-3p;hsa-miR-16-1-3p;hsa-miR-16-2-3p;hsa-miR-16-5p;hsa-miR-186-5p;hsa-miR-194-5p;hsa-miR-197-3p;hsa-miR-200a-3p;hsa-miR-301a-3p;hsa-miR-30b-5p;hsa-miR-30c-5p;hsa-miR-30d-5p;hsa-miR-30e-5p;hsa-miR-320a;hsa-miR-320b;hsa-miR-324-5p;hsa-miR-330-5p;hsa-miR-335-5p;hsa-miR-3607-3p;hsa-miR-429;hsa-miR-582-5p;hsa-miR-590-3p;hsa-miR-590-5p;hsa-miR-664a-3p;hsa-miR-7-1-3p;hsa-miR-944 | 28 | NRP1 | Sponge network | -4.237 | 0 | -0.612 | 0.02915 | 0.31 |
| 39 | RP1-151F17.2 | hsa-miR-130b-3p;hsa-miR-16-1-3p;hsa-miR-16-2-3p;hsa-miR-186-5p;hsa-miR-194-5p;hsa-miR-197-3p;hsa-miR-301a-3p;hsa-miR-30b-5p;hsa-miR-30c-5p;hsa-miR-30d-5p;hsa-miR-30e-5p;hsa-miR-320a;hsa-miR-320b;hsa-miR-335-5p;hsa-miR-3607-3p;hsa-miR-421;hsa-miR-454-3p;hsa-miR-590-3p;hsa-miR-590-5p;hsa-miR-7-1-3p | 20 | NRP1 | Sponge network | -1.606 | 0 | -0.612 | 0.02915 | 0.306 |
| 40 | RP11-326C3.11 | hsa-miR-130b-3p;hsa-miR-141-3p;hsa-miR-16-1-3p;hsa-miR-16-2-3p;hsa-miR-16-5p;hsa-miR-186-5p;hsa-miR-200a-3p;hsa-miR-28-5p;hsa-miR-301a-3p;hsa-miR-330-5p | 10 | NRP1 | Sponge network | -1.196 | 3.0E-5 | -0.612 | 0.02915 | 0.305 |
| 41 | LINC00883 | hsa-miR-130b-3p;hsa-miR-141-3p;hsa-miR-16-1-3p;hsa-miR-186-5p;hsa-miR-194-5p;hsa-miR-197-3p;hsa-miR-200a-3p;hsa-miR-301a-3p;hsa-miR-324-5p;hsa-miR-330-5p;hsa-miR-582-5p;hsa-miR-664a-3p | 12 | NRP1 | Sponge network | -0.614 | 0.0511 | -0.612 | 0.02915 | 0.305 |
| 42 | LINC00473 | hsa-miR-130b-3p;hsa-miR-16-1-3p;hsa-miR-16-2-3p;hsa-miR-16-5p;hsa-miR-186-5p;hsa-miR-194-5p;hsa-miR-197-3p;hsa-miR-301a-3p;hsa-miR-320a;hsa-miR-320b;hsa-miR-324-5p;hsa-miR-330-5p;hsa-miR-3607-3p;hsa-miR-361-5p;hsa-miR-454-3p;hsa-miR-590-3p;hsa-miR-664a-3p;hsa-miR-7-1-3p | 18 | NRP1 | Sponge network | -5.53 | 0 | -0.612 | 0.02915 | 0.304 |
| 43 | PDZRN3-AS1 | hsa-miR-130b-3p;hsa-miR-141-3p;hsa-miR-16-1-3p;hsa-miR-16-2-3p;hsa-miR-16-5p;hsa-miR-186-5p;hsa-miR-194-5p;hsa-miR-197-3p;hsa-miR-200a-3p;hsa-miR-301a-3p;hsa-miR-320a;hsa-miR-320b;hsa-miR-324-5p;hsa-miR-3607-3p;hsa-miR-361-5p;hsa-miR-590-3p;hsa-miR-590-5p;hsa-miR-7-1-3p | 18 | NRP1 | Sponge network | -5.049 | 1.0E-5 | -0.612 | 0.02915 | 0.297 |
| 44 | RP11-815I9.4 | hsa-miR-16-1-3p;hsa-miR-16-2-3p;hsa-miR-16-5p;hsa-miR-186-5p;hsa-miR-197-3p;hsa-miR-28-5p;hsa-miR-301a-3p;hsa-miR-30c-5p;hsa-miR-320a;hsa-miR-320b;hsa-miR-330-5p;hsa-miR-3607-3p;hsa-miR-590-5p;hsa-miR-664a-3p;hsa-miR-7-1-3p | 15 | NRP1 | Sponge network | -0.665 | 0.01108 | -0.612 | 0.02915 | 0.295 |
| 45 | RP11-360F5.1 | hsa-miR-130b-3p;hsa-miR-141-3p;hsa-miR-16-1-3p;hsa-miR-16-2-3p;hsa-miR-194-5p;hsa-miR-200a-3p;hsa-miR-320a;hsa-miR-320b;hsa-miR-324-5p;hsa-miR-429 | 10 | NRP1 | Sponge network | -0.286 | 0.77753 | -0.612 | 0.02915 | 0.293 |
| 46 | RP11-180N14.1 | hsa-miR-130b-3p;hsa-miR-141-3p;hsa-miR-16-1-3p;hsa-miR-16-2-3p;hsa-miR-16-5p;hsa-miR-186-5p;hsa-miR-194-5p;hsa-miR-197-3p;hsa-miR-200a-3p;hsa-miR-301a-3p;hsa-miR-7-1-3p;hsa-miR-944 | 12 | NRP1 | Sponge network | -4.46 | 0 | -0.612 | 0.02915 | 0.292 |
| 47 | AC005682.5 | hsa-miR-130b-3p;hsa-miR-141-3p;hsa-miR-186-5p;hsa-miR-194-5p;hsa-miR-197-3p;hsa-miR-200a-3p;hsa-miR-301a-3p;hsa-miR-330-5p;hsa-miR-335-5p;hsa-miR-454-3p | 10 | NRP1 | Sponge network | -0.787 | 0.08468 | -0.612 | 0.02915 | 0.291 |
| 48 | RP11-25K19.1 | hsa-miR-130b-3p;hsa-miR-16-1-3p;hsa-miR-186-5p;hsa-miR-194-5p;hsa-miR-197-3p;hsa-miR-301a-3p;hsa-miR-320a;hsa-miR-320b;hsa-miR-429;hsa-miR-944 | 10 | NRP1 | Sponge network | -1.478 | 0.00829 | -0.612 | 0.02915 | 0.291 |
| 49 | CTD-2013N24.2 | hsa-miR-130b-3p;hsa-miR-141-3p;hsa-miR-16-1-3p;hsa-miR-16-2-3p;hsa-miR-16-5p;hsa-miR-186-5p;hsa-miR-194-5p;hsa-miR-197-3p;hsa-miR-200a-3p;hsa-miR-301a-3p;hsa-miR-30b-5p;hsa-miR-30c-5p;hsa-miR-30d-5p;hsa-miR-30e-5p;hsa-miR-330-5p;hsa-miR-3607-3p;hsa-miR-361-5p;hsa-miR-429;hsa-miR-454-3p;hsa-miR-590-3p;hsa-miR-7-1-3p | 21 | NRP1 | Sponge network | -1.002 | 1.0E-5 | -0.612 | 0.02915 | 0.291 |
| 50 | AC079767.4 | hsa-miR-130b-3p;hsa-miR-141-3p;hsa-miR-200a-3p;hsa-miR-301a-3p;hsa-miR-30b-5p;hsa-miR-30c-5p;hsa-miR-30d-5p;hsa-miR-30e-5p;hsa-miR-324-5p;hsa-miR-944 | 10 | NRP1 | Sponge network | 0.594 | 0.61846 | -0.612 | 0.02915 | 0.289 |
| 51 | LINC00654 | hsa-miR-130b-3p;hsa-miR-141-3p;hsa-miR-16-1-3p;hsa-miR-16-2-3p;hsa-miR-16-5p;hsa-miR-186-5p;hsa-miR-194-5p;hsa-miR-197-3p;hsa-miR-200a-3p;hsa-miR-301a-3p;hsa-miR-30b-5p;hsa-miR-30c-5p;hsa-miR-30d-5p;hsa-miR-30e-5p;hsa-miR-320a;hsa-miR-320b;hsa-miR-324-5p;hsa-miR-330-5p;hsa-miR-3607-3p;hsa-miR-361-5p;hsa-miR-429;hsa-miR-454-3p;hsa-miR-590-3p;hsa-miR-7-1-3p;hsa-miR-944 | 25 | NRP1 | Sponge network | -1.448 | 0.00044 | -0.612 | 0.02915 | 0.28 |
| 52 | RP11-1008C21.2 | hsa-miR-130b-3p;hsa-miR-141-3p;hsa-miR-16-2-3p;hsa-miR-16-5p;hsa-miR-186-5p;hsa-miR-197-3p;hsa-miR-200a-3p;hsa-miR-301a-3p;hsa-miR-320b;hsa-miR-330-5p;hsa-miR-3607-3p;hsa-miR-361-5p;hsa-miR-421 | 13 | NRP1 | Sponge network | -0.999 | 0.0012 | -0.612 | 0.02915 | 0.276 |
| 53 | RP11-426C22.5 | hsa-miR-130b-3p;hsa-miR-141-3p;hsa-miR-16-1-3p;hsa-miR-16-2-3p;hsa-miR-16-5p;hsa-miR-186-5p;hsa-miR-194-5p;hsa-miR-197-3p;hsa-miR-200a-3p;hsa-miR-301a-3p;hsa-miR-330-5p;hsa-miR-421;hsa-miR-582-5p;hsa-miR-664a-3p;hsa-miR-7-1-3p | 15 | NRP1 | Sponge network | -0.559 | 0.08048 | -0.612 | 0.02915 | 0.271 |
| 54 | BZRAP1-AS1 | hsa-miR-130b-3p;hsa-miR-141-3p;hsa-miR-16-1-3p;hsa-miR-16-5p;hsa-miR-186-5p;hsa-miR-194-5p;hsa-miR-197-3p;hsa-miR-200a-3p;hsa-miR-301a-3p;hsa-miR-330-5p;hsa-miR-335-5p;hsa-miR-361-5p;hsa-miR-454-3p;hsa-miR-944 | 14 | NRP1 | Sponge network | -2.343 | 0 | -0.612 | 0.02915 | 0.269 |
| 55 | RP11-20J15.3 | hsa-miR-16-1-3p;hsa-miR-16-5p;hsa-miR-186-5p;hsa-miR-194-5p;hsa-miR-197-3p;hsa-miR-301a-3p;hsa-miR-320a;hsa-miR-320b;hsa-miR-361-5p;hsa-miR-582-5p | 10 | NRP1 | Sponge network | -5.104 | 8.0E-5 | -0.612 | 0.02915 | 0.257 |
| 56 | RP11-693J15.4 | hsa-miR-130b-3p;hsa-miR-141-3p;hsa-miR-16-1-3p;hsa-miR-16-2-3p;hsa-miR-16-5p;hsa-miR-186-5p;hsa-miR-194-5p;hsa-miR-197-3p;hsa-miR-200a-3p;hsa-miR-301a-3p;hsa-miR-320a;hsa-miR-320b;hsa-miR-582-5p;hsa-miR-590-5p;hsa-miR-664a-3p;hsa-miR-7-1-3p | 16 | NRP1 | Sponge network | -3.319 | 0.00281 | -0.612 | 0.02915 | 0.254 |
| 57 | RP11-35G9.3 | hsa-miR-141-3p;hsa-miR-186-5p;hsa-miR-194-5p;hsa-miR-197-3p;hsa-miR-200a-3p;hsa-miR-301a-3p;hsa-miR-320a;hsa-miR-320b;hsa-miR-421;hsa-miR-429;hsa-miR-664a-3p | 11 | NRP1 | Sponge network | -0.328 | 0.16721 | -0.612 | 0.02915 | 0.253 |
| 58 | RP11-456K23.1 | hsa-miR-130b-3p;hsa-miR-141-3p;hsa-miR-148a-3p;hsa-miR-16-1-3p;hsa-miR-16-2-3p;hsa-miR-16-5p;hsa-miR-186-5p;hsa-miR-194-5p;hsa-miR-197-3p;hsa-miR-200a-3p;hsa-miR-28-5p;hsa-miR-301a-3p;hsa-miR-320a;hsa-miR-320b;hsa-miR-324-5p;hsa-miR-3607-3p;hsa-miR-429;hsa-miR-454-3p;hsa-miR-590-3p;hsa-miR-590-5p | 20 | NRP1 | Sponge network | -1.962 | 1.0E-5 | -0.612 | 0.02915 | 0.252 |