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This regulatory network was inferred from the input dataset. The miRNAs and mRNAs are presented as round and rectangle nodes respectively. The numerical value popped up upon mouse over the gene node is the log2 transformed fold-change of the gene expression between the two groups. All of the nodes are clickable, and the detailed information of the miRNAs/mRNAs and related cancer pathway will be displayed in another window. The edges between nodes are supported by both interactions (predicted or experimentally verified) and correlations learnt from cancer dataset. The numerical value popped up upon mouse over the edge is the correlation beat value (effect size) between the two nodes. The experimental evidences of the edges reported in previous cancer studies are highlighted by red/orange color. All of these information can be accessed by the "mouse-over" action. This network shows a full map of the miRNA-mRNA regulation of the input gene list(s), and the hub miRNAs (with the high network degree/betweenness centrality) would be the potential cancer drivers or tumor suppressors. The full result table can be accessed in the "Regulations" tab.

"miRNACancerMAP" is also a network visualization tool for users to draw their regulatory network by personal customization. Users can set the complexity of the network by limiting the number of nodes or edges. And the color of the nodes can be defined by different categories of the mRNAs and miRNAs, such as Gene-Ontology, pathway, and expression status. Users can also select to use network degree or network betweenness centrality to define the node size. And edges can be black or colored by the correlation. Purple edge means negative correlation (mostly found between miRNA and mRNA), and blue edge means positive correlation (found in PPI or miRNA-miRNA sponge effect). We can also add the protein-protein interactions (PPI) into the network. This result will show the cluster of genes regulated by some specific miRNAs. Additionally, miRNA-miRNA edges can be added by the "miRNA sponge" button, presenting some clusters of miRNAs that have the interactions via sponge effect.

miRNA-gene regulations

(Download full result)

Num microRNA           Gene miRNA log2FC miRNA pvalue Gene log2FC Gene pvalue Interaction Correlation beta Correlation P-value PMID Reported in cancer studies
1 hsa-miR-200b-3p ABCA1 2.06 0 0.61 0.0002 TargetScan -0.16 0 NA
2 hsa-miR-192-5p ABCA8 2.09 0 -2.99 0 miRNAWalker2 validate -0.49 0 NA
3 hsa-miR-200b-3p ABI2 2.06 0 0.18 0.14787 TargetScan -0.17 0 NA
4 hsa-miR-21-5p ACAT1 2.22 0 -0.96 0 miRNAWalker2 validate -0.32 0 NA
5 hsa-miR-192-5p ACSL1 2.09 0 -0.58 4.0E-5 miRNAWalker2 validate -0.11 0 NA
6 hsa-miR-200b-3p ACTR1A 2.06 0 -0.4 0 TargetScan -0.11 0 NA
7 hsa-miR-200b-3p ADAMTS3 2.06 0 0.38 0.04723 TargetScan -0.18 0 NA
8 hsa-miR-200b-3p ADCY2 2.06 0 -1.53 4.0E-5 TargetScan -0.62 0 NA
9 hsa-miR-200b-3p ADCY9 2.06 0 -0.36 0.01911 TargetScan -0.21 0 NA
10 hsa-miR-200b-3p AFF1 2.06 0 -0.38 0.00053 TargetScan -0.14 0 NA
11 hsa-miR-200b-3p AFF3 2.06 0 -2.37 0 TargetScan -0.56 0 NA
12 hsa-miR-18a-5p AFF4 2.05 0 -0.27 0.01565 miRNAWalker2 validate -0.15 0 NA
13 hsa-miR-200b-3p AHNAK 2.06 0 -1.21 0 TargetScan -0.32 0 NA
14 hsa-miR-183-5p AKAP12 2.08 0 -0.93 0.0028 miRNAWalker2 validate; miRTarBase -0.57 0 NA
15 hsa-miR-21-5p AKT2 2.22 0 -0.16 0.09338 miRNAWalker2 validate -0.13 0.00012 NA
16 hsa-miR-146b-5p AKT3 2.23 0 -0.27 0.18865 miRNAWalker2 validate -0.26 0 NA
17 hsa-miR-200b-3p AMOTL2 2.06 0 0.15 0.30776 TargetScan -0.11 1.0E-5 NA
18 hsa-miR-192-5p ANKRD6 2.09 0 -0.36 0.03942 miRNAWalker2 validate -0.21 0 NA
19 hsa-miR-200b-3p ANO5 2.06 0 -2.17 0 TargetScan -0.49 0 NA
20 hsa-miR-192-5p ANO6 2.09 0 -0.09 0.50227 miRNAWalker2 validate -0.11 0 NA
21 hsa-miR-200b-3p ANO6 2.06 0 -0.09 0.50227 TargetScan -0.16 0 NA
22 hsa-miR-192-5p AP1S2 2.09 0 -0.61 0.00205 miRNAWalker2 validate -0.34 0 NA
23 hsa-miR-200b-3p AP1S2 2.06 0 -0.61 0.00205 TargetScan -0.41 0 NA
24 hsa-miR-192-5p APOLD1 2.09 0 -0.38 0.04851 miRNAWalker2 validate -0.13 2.0E-5 NA
25 hsa-miR-21-5p APOLD1 2.22 0 -0.38 0.04851 miRNAWalker2 validate -0.28 2.0E-5 NA
26 hsa-miR-200b-3p ARHGAP20 2.06 0 -1.38 0 TargetScan -0.53 0 NA
27 hsa-miR-192-5p ARHGAP29 2.09 0 0.13 0.42953 miRNAWalker2 validate -0.13 0 NA
28 hsa-miR-200b-3p ARHGAP6 2.06 0 -0.53 0.04006 TargetScan -0.29 0 NA
29 hsa-miR-192-5p ARHGEF10 2.09 0 -0.1 0.61 miRNAWalker2 validate -0.17 0 NA
30 hsa-miR-200b-3p ARHGEF17 2.06 0 0.03 0.85895 TargetScan -0.34 0 NA
31 hsa-miR-192-5p ARHGEF26 2.09 0 -1.96 0 miRNAWalker2 validate -0.51 0 NA
32 hsa-miR-192-5p ARL2BP 2.09 0 -0.34 3.0E-5 miRNAWalker2 validate -0.11 0 NA
33 hsa-miR-200b-3p ARL2BP 2.06 0 -0.34 3.0E-5 TargetScan -0.11 0 NA
34 hsa-miR-200b-3p ARL3 2.06 0 -0.52 0 TargetScan -0.15 0 NA
35 hsa-miR-133a-3p ARL6IP1 -2.63 0 0.58 1.0E-5 miRNAWalker2 validate -0.14 0 NA
36 hsa-miR-21-5p ARMCX3 2.22 0 -0.17 0.29447 miRNAWalker2 validate -0.12 0.03566 NA
37 hsa-miR-200b-3p ARRDC3 2.06 0 -0.15 0.28741 TargetScan -0.12 0 NA
38 hsa-miR-200b-3p ASXL3 2.06 0 -1.88 0 TargetScan -0.46 0 NA
39 hsa-miR-200b-3p ATL2 2.06 0 -0.38 0.00058 TargetScan -0.14 0 NA
40 hsa-miR-18a-5p ATM 2.05 0 0.18 0.21568 miRNAWalker2 validate; miRTarBase -0.11 0.00023 23437304; 25963391; 23857602; 23229340 MicroRNA 18a attenuates DNA damage repair through suppressing the expression of ataxia telangiectasia mutated in colorectal cancer; Through in silico search the 3'UTR of Ataxia telangiectasia mutated ATM contains a conserved miR-18a binding site; Expression of ATM was down-regulated in CRC tumors p<0.0001 and inversely correlated with miR-18a expression r = -0.4562 p<0.01; This was further confirmed by the down-regulation of ATM protein by miR-18a; As ATM is a key enzyme in DNA damage repair we evaluated the effect of miR-18a on DNA double-strand breaks; miR-18a attenuates cellular repair of DNA double-strand breaks by directly suppressing ATM a key enzyme in DNA damage repair;However the upregulation of miR-18a suppressed the level of ataxia-telangiectasia mutated and attenuated DNA double-strand break repair after irradiation which re-sensitized the cervical cancer cells to radiotherapy by promoting apoptosis;Furthermore we used antisense oligonucleotides against micro RNAs miRNA or miRNA overexpression plasmids to study the role of miR-18a and -106a on ATM expression; Furthermore we identified that ERα activates miR-18a and -106a to downregulate ATM expression; We reveal a novel mechanism involving ERα and miR-18a and -106a regulation of ATM in breast cancer;MicroRNA 18a upregulates autophagy and ataxia telangiectasia mutated gene expression in HCT116 colon cancer cells; Previous studies showed that certain microRNAs including miR-18a potentially regulate ATM in cancer cells; However the mechanisms behind the modulation of ATM by miR-18a remain to be elucidated in colon cancer cells; In the present study we explored the impact of miR-18a on the autophagy process and ATM expression in HCT116 colon cancer cells; Western blotting and luciferase assays were implemented to explore the impact of miR-18a on ATM gene expression in HCT116 cells; Moreover miR-18a overexpression led to the upregulation of ATM expression and suppression of mTORC1 activity; Results of the present study pertaining to the role of miR-18a in regulating autophagy and ATM gene expression in colon cancer cells revealed a novel function for miR-18a in a critical cellular event and on a crucial gene with significant impacts in cancer development progression treatment and in other diseases
41 hsa-miR-192-5p ATP10D 2.09 0 -0.37 0.00764 miRNAWalker2 validate -0.12 0 NA
42 hsa-miR-21-5p ATP2B4 2.22 0 -0.64 0.00597 miRNAWalker2 validate -0.5 0 NA
43 hsa-miR-192-5p ATRNL1 2.09 0 -1.69 1.0E-5 miRNAWalker2 validate -0.33 0 NA
44 hsa-miR-200b-3p ATXN1 2.06 0 -0.51 0.00026 TargetScan -0.23 0 NA
45 hsa-miR-200b-3p AUTS2 2.06 0 -0.27 0.18068 TargetScan -0.16 1.0E-5 NA
46 hsa-miR-21-5p AUTS2 2.22 0 -0.27 0.18068 miRNAWalker2 validate -0.22 0.00112 NA
47 hsa-miR-192-5p B3GALNT1 2.09 0 0.08 0.70688 miRNAWalker2 validate -0.14 1.0E-5 NA
48 hsa-miR-200b-3p BACH2 2.06 0 -0.15 0.55909 TargetScan -0.28 0 NA
49 hsa-miR-200b-3p BBX 2.06 0 0.14 0.22968 TargetScan -0.12 0 NA
50 hsa-miR-196a-5p BCL11A 5.06 0 -0.93 0.0063 miRNAWalker2 validate -0.1 0.01003 NA
51 hsa-miR-192-5p BCL2 2.09 0 -0.9 0 miRNAWalker2 validate -0.22 0 26550150 MicroRNA 192 regulates chemo resistance of lung adenocarcinoma for gemcitabine and cisplatin combined therapy by targeting Bcl 2; In this paper we try to test whether miR-192 regulates chemo-resistance in human carcinoma A549 mice model by targeting Bcl-2; MTT assay real-time RT-PCR western blotting assay were used to investigate miR-192 expression levels cell viability ratio and Bcl-2 protein expression levels; Bcl-2 mRNA and protein expression levels up-regulated in miR-192 inhibitor treated tumor; Bcl-2 is a key regulator for miR-192 related chemotherapy resistance; In this study we demonstrate that miR-192 regulates chemoresistance for gemcitabine and cisplatin combined chemotherapy in human adenocarcinoma lung cancer A549 cells and Bcl-2 is the target of miR-192
52 hsa-miR-196b-5p BCL2 4.52 0 -0.9 0 miRNAWalker2 validate -0.14 0 NA
53 hsa-miR-200b-3p BCL2 2.06 0 -0.9 0 miRNAWalker2 validate; miRTarBase; TargetScan -0.27 0 NA
54 hsa-miR-21-5p BCL2 2.22 0 -0.9 0 miRNAWalker2 validate; miRTarBase -0.4 0 21468550; 25994220; 25381586; 26555418; 23359184; 22964582; 21376256 BCL-2 up-regulation could be achieved by miR-21 overexpression which prevented T24 cells from apoptosis induced by doxorubicin; Furthermore the miR-21 induced BCL-2 up-regulation could be cancelled by the PI3K inhibitor LY294002;Meanwhile miR-21 loss reduced STAT3 and Bcl-2 activation causing an increase in the apoptosis of tumour cells in CAC mice;Changes in the sensitivity of osteosarcoma cells to CDDP were examined after transfection with miR-21 mimics or anti-miR-21 or bcl-2 siRNA in combination with CDDP;The expression of Bax Bcl-2 and miR-21 in parental and paclitaxel-resistant cells was detected by RT-PCR and Western blotting;Resveratrol induces apoptosis of pancreatic cancers cells by inhibiting miR 21 regulation of BCL 2 expression; We also used Western blot to measure BCL-2 protein levels after down-regulation of miR-21 expression; Besides down-regulation of miR-21 expression can inhibit BCL-2 expression in PANC-1 CFPAC-1 and MIA Paca-2 cells; Over-expression of miR-21 expression can reverse down-regulation of BCL-2 expression and apoptosis induced by resveratrol; In this study we demonstrated that the effect of resveratrol on apoptosis is due to inhibiting miR-21 regulation of BCL-2 expression;Tumors harvested from these lungs have elevated levels of oncogenic miRNAs miR-21 and miR-155; are deficient for p53-regulated miRNAs; and have heightened expression of miR-34 target genes such as Met and Bcl-2;Bcl 2 upregulation induced by miR 21 via a direct interaction is associated with apoptosis and chemoresistance in MIA PaCa 2 pancreatic cancer cells; However the roles and mechanisms of miRNA miR-21 in regulation of Bcl-2 in pancreatic cancer remain to be elucidated; Then luciferase activity was observed after miR-21 mimics and pRL-TK plasmids containing wild-type and mutant 3'UTRs of Bcl-2 mRNA were co-transfected; Cells transfected with miR-21 inhibitor revealed an opposite trend. There was a significant increase in luciferase activity in the cells transfected with the wild-type pRL-TK plasmid in contrast to those transfected with the mutant one indicating that miR-21 promotes Bcl-2 expression by binding directly to the 3'UTR of Bcl-2 mRNA; Upregulation of Bcl-2 directly induced by miR-21 is associated with apoptosis chemoresistance and proliferation of MIA PaCa-2 pancreatic cancer cells
55 hsa-miR-133a-3p BCL2L1 -2.63 0 0.54 0.00023 miRNAWalker2 validate -0.11 0 23756231 Furthermore bioinformatic prediction and experimental validation were applied to identify target genes of miR-133a and the results revealed that the anti-tumor effect of miR-133a was probably due to targeting and repressing of Bcl-xL and Mcl-1 expression
56 hsa-miR-21-5p BCL6 2.22 0 -0.21 0.19489 miRNAWalker2 validate -0.17 0.00271 NA
57 hsa-miR-21-5p BDH2 2.22 0 -1.2 0 miRNAWalker2 validate -0.28 0 NA
58 hsa-miR-192-5p BGLAP 2.09 0 -0.9 0 miRNAWalker2 validate -0.16 0 NA
59 hsa-miR-200b-3p BHLHE41 2.06 0 0.35 0.12753 TargetScan -0.16 0.0001 NA
60 hsa-miR-200b-3p BICC1 2.06 0 0.84 0.0014 TargetScan -0.29 0 NA
61 hsa-miR-200b-3p BICD2 2.06 0 -0.02 0.88611 TargetScan -0.17 0 NA
62 hsa-miR-192-5p BMPR2 2.09 0 0.21 0.0635 miRNAWalker2 validate -0.1 0 NA
63 hsa-miR-200b-3p BNC2 2.06 0 -0.49 0.09988 TargetScan -0.55 0 NA
64 hsa-miR-21-5p BOC 2.22 0 -0.91 0.0056 miRNAWalker2 validate -0.63 0 NA
65 hsa-miR-21-5p BTBD3 2.22 0 -0.1 0.50084 miRNAWalker2 validate -0.1 0.03696 NA
66 hsa-miR-21-5p BTBD7 2.22 0 -0.17 0.03473 miRNAWalker2 validate -0.1 0.00018 NA
67 hsa-miR-192-5p BTC 2.09 0 -1.69 0 miRNAWalker2 validate -0.26 0 NA
68 hsa-miR-192-5p BTF3L4 2.09 0 0.18 0.05058 miRNAWalker2 validate -0.1 0 NA
69 hsa-miR-21-5p BTG2 2.22 0 -1.76 0 miRNAWalker2 validate; miRTarBase -0.78 0 24821435 miR 21 regulates N methyl N nitro N' nitrosoguanidine induced gastric tumorigenesis by targeting FASLG and BTG2
70 hsa-miR-18a-5p BVES 2.05 0 -1.51 1.0E-5 miRNAWalker2 validate -0.69 0 NA
71 hsa-miR-192-5p C1QTNF3 2.09 0 -1.29 3.0E-5 miRNAWalker2 validate -0.38 0 NA
72 hsa-miR-192-5p CAB39L 2.09 0 -1.77 0 miRNAWalker2 validate -0.4 0 NA
73 hsa-miR-200b-3p CACHD1 2.06 0 -0.32 0.13899 TargetScan -0.14 0.00048 NA
74 hsa-miR-200b-3p CACNA1C 2.06 0 -0.18 0.557 TargetScan -0.53 0 NA
75 hsa-miR-200b-3p CACNA2D1 2.06 0 -0.85 0.00675 TargetScan -0.43 0 NA
76 hsa-miR-192-5p CADM1 2.09 0 -0.9 0.00084 miRNAWalker2 validate -0.26 0 NA
77 hsa-miR-200b-3p CADM1 2.06 0 -0.9 0.00084 TargetScan -0.26 0 NA
78 hsa-miR-21-5p CALD1 2.22 0 -0.5 0.08544 miRNAWalker2 validate -0.47 0 NA
79 hsa-miR-192-5p CAMK4 2.09 0 -0.6 0.01183 miRNAWalker2 validate -0.1 0.00723 NA
80 hsa-miR-200b-3p CAMSAP2 2.06 0 0.42 0.00053 TargetScan -0.12 0 NA
81 hsa-miR-1-3p CAND1 -2.73 0 0.4 0.00013 miRTarBase -0.11 0 NA
82 hsa-miR-200b-3p CASD1 2.06 0 -0.06 0.67432 TargetScan -0.14 0 NA
83 hsa-miR-200b-3p CBX5 2.06 0 0.16 0.24446 TargetScan -0.1 3.0E-5 NA
84 hsa-miR-21-5p CCNG1 2.22 0 -0.7 0 miRNAWalker2 validate -0.16 0.00089 NA
85 hsa-miR-200b-3p CDC42EP3 2.06 0 -0.12 0.56698 TargetScan -0.37 0 NA
86 hsa-miR-200b-3p CDH11 2.06 0 1.43 0 TargetScan -0.2 0 NA
87 hsa-miR-194-5p CDH2 2.24 0 -0.68 0.04042 miRNAWalker2 validate; miRTarBase -0.38 0 21845495; 20979124 The results of real-time PCR and western blot highlighted that miR-194 interacted with N-cadherin and negatively regulated its expression at the translational level;The overexpression of miR-194 in liver mesenchymal-like cancer cells reduced the expression of the mesenchymal cell marker N-cadherin and suppressed invasion and migration of the mesenchymal-like cancer cells both in vitro and in vivo
88 hsa-miR-192-5p CDK14 2.09 0 -0.3 0.18672 miRNAWalker2 validate -0.24 0 NA
89 hsa-miR-200b-3p CDK17 2.06 0 0.07 0.48708 TargetScan -0.12 0 NA
90 hsa-miR-146b-5p CDKN1A 2.23 0 -1.27 0 miRNAWalker2 validate -0.22 0 27602131 During the search for potential targets of miR-146b in ATC p21 also known as p21Waf1/Cip1 or CDKN1A was noted for its role in cell cycle progression and tumor pathogenesis
91 hsa-miR-192-5p CDON 2.09 0 -0.74 0.01452 miRNAWalker2 validate -0.41 0 NA
92 hsa-miR-200b-3p CEBPD 2.06 0 -0.99 0 TargetScan -0.22 0 NA
93 hsa-miR-200b-3p CECR2 2.06 0 -0.99 0.00379 TargetScan -0.38 0 NA
94 hsa-miR-200b-3p CELF2 2.06 0 -1.1 1.0E-5 TargetScan -0.43 0 NA
95 hsa-miR-200b-3p CEP85L 2.06 0 -0.89 0 TargetScan -0.19 0 NA
96 hsa-miR-192-5p CFL2 2.09 0 -1.3 0 miRNAWalker2 validate -0.48 0 NA
97 hsa-miR-200b-3p CFL2 2.06 0 -1.3 0 TargetScan -0.61 0 NA
98 hsa-miR-192-5p CGNL1 2.09 0 -1.61 0 miRNAWalker2 validate -0.44 0 NA
99 hsa-miR-200b-3p CHRDL1 2.06 0 -2.81 0 TargetScan -1.01 0 NA
100 hsa-miR-200b-3p CHST9 2.06 0 -3.2 0 TargetScan -0.58 0 NA
101 hsa-miR-200b-3p CITED2 2.06 0 -1.54 0 TargetScan -0.29 0 NA
102 hsa-miR-196b-5p CKB 4.52 0 -2.84 0 miRNAWalker2 validate -0.23 0 NA
103 hsa-miR-935 CKB 2.32 0 -2.84 0 miRNAWalker2 validate -0.41 0 NA
104 hsa-miR-200b-3p CLASP1 2.06 0 0.09 0.35045 TargetScan -0.14 0 NA
105 hsa-miR-200b-3p CLIC4 2.06 0 -0.39 0.04124 TargetScan -0.37 0 NA
106 hsa-miR-200b-3p CLIP1 2.06 0 -0.22 0.08684 TargetScan -0.2 0 NA
107 hsa-miR-192-5p CLIP4 2.09 0 -1.15 1.0E-5 miRNAWalker2 validate -0.42 0 NA
108 hsa-miR-21-5p CLIP4 2.22 0 -1.15 1.0E-5 miRNAWalker2 validate -0.52 0 NA
109 hsa-miR-192-5p CLK1 2.09 0 -0.16 0.22307 miRNAWalker2 validate -0.12 0 NA
110 hsa-miR-192-5p CLK4 2.09 0 -0.08 0.49185 miRNAWalker2 validate -0.11 0 NA
111 hsa-miR-200b-3p CNN3 2.06 0 -0.56 0.00032 TargetScan -0.24 0 NA
112 hsa-miR-200b-3p CNTFR 2.06 0 -3.86 0 TargetScan -0.49 0 NA
113 hsa-miR-200b-3p CNTN4 2.06 0 -0.83 0.00133 TargetScan -0.28 0 NA
114 hsa-miR-192-5p CNTNAP3 2.09 0 -1.46 0.00033 miRNAWalker2 validate -0.53 0 NA
115 hsa-miR-133a-3p COL1A1 -2.63 0 3.02 0 miRNAWalker2 validate -0.15 0.00287 NA
116 hsa-miR-200b-3p COL4A3 2.06 0 -0.75 0.03615 TargetScan -0.33 0 NA
117 hsa-miR-200b-3p CORO1C 2.06 0 -0.06 0.60556 TargetScan -0.2 0 NA
118 hsa-miR-192-5p CORO2B 2.09 0 -1.18 2.0E-5 miRNAWalker2 validate -0.32 0 NA
119 hsa-miR-21-5p CPEB3 2.22 0 -0.73 0 miRNAWalker2 validate -0.22 0 NA
120 hsa-miR-183-5p CR1 2.08 0 -0.14 0.65637 miRNAWalker2 validate -0.27 0 NA
121 hsa-miR-200b-3p CREB5 2.06 0 0.01 0.953 TargetScan -0.28 0 NA
122 hsa-miR-18a-5p CREBL2 2.05 0 -0.29 0.00289 miRNAWalker2 validate -0.15 0 NA
123 hsa-miR-200b-3p CRTAP 2.06 0 -0.49 0.00014 TargetScan -0.25 0 NA
124 hsa-miR-192-5p CSGALNACT2 2.09 0 0.61 0 miRNAWalker2 validate -0.11 0 NA
125 hsa-miR-18a-5p CSRNP3 2.05 0 -0.89 0.00073 miRNAWalker2 validate -0.4 0 NA
126 hsa-miR-200b-3p CSRNP3 2.06 0 -0.89 0.00073 TargetScan -0.33 0 NA
127 hsa-miR-18a-5p CTGF 2.05 0 0.32 0.11682 miRNAWalker2 validate; miRTarBase -0.23 0 23249750 Targeting of TGFβ signature and its essential component CTGF by miR 18 correlates with improved survival in glioblastoma; Indeed microRNA-18a but not other miR-17∼92 members has a functional site in the CTGF 3' UTR and its forced reexpression sharply reduces CTGF protein and mRNA levels; The unexpected effects of miR-18a on CTGF transcription are mediated in part by direct targeting of Smad3 and ensuing weakening of TGFβ signaling
128 hsa-miR-200b-3p CTNND2 2.06 0 -1.48 0.0026 TargetScan -0.35 7.0E-5 NA
129 hsa-miR-21-5p CYBRD1 2.22 0 -1.57 0 miRNAWalker2 validate -0.54 0 NA
130 hsa-miR-200b-3p CYP1B1 2.06 0 -0.77 0.05307 TargetScan -0.63 0 NA
131 hsa-miR-200b-3p CYTH3 2.06 0 0.12 0.35924 TargetScan -0.14 0 NA
132 hsa-miR-21-5p DAAM1 2.22 0 -0.34 0.0105 miRNAWalker2 validate -0.19 2.0E-5 NA
133 hsa-miR-18a-5p DAAM2 2.05 0 -1.34 0 miRNAWalker2 validate -0.59 0 NA
134 hsa-miR-200b-3p DACT1 2.06 0 0.78 0.00072 TargetScan -0.2 0 NA
135 hsa-miR-200b-3p DCAF5 2.06 0 -0.43 0 TargetScan -0.12 0 NA
136 hsa-miR-21-5p DCAF8 2.22 0 -0.36 0 miRNAWalker2 validate -0.2 0 NA
137 hsa-miR-192-5p DCBLD2 2.09 0 -0.14 0.5524 miRNAWalker2 validate -0.27 0 NA
138 hsa-miR-200b-3p DCBLD2 2.06 0 -0.14 0.5524 TargetScan -0.31 0 NA
139 hsa-miR-21-5p DDHD2 2.22 0 -0.15 0.19384 miRNAWalker2 validate -0.12 0.00385 NA
140 hsa-miR-21-5p DDR2 2.22 0 -0.76 0.00669 miRNAWalker2 validate -0.5 0 NA
141 hsa-miR-200b-3p DDX3Y 2.06 0 -1.08 0.26927 TargetScan -0.38 0.03181 NA
142 hsa-miR-192-5p DEGS1 2.09 0 -0.17 0.10365 miRNAWalker2 validate -0.11 0 NA
143 hsa-miR-200b-3p DENND5A 2.06 0 -0.15 0.39059 TargetScan -0.34 0 NA
144 hsa-miR-200b-3p DIRAS2 2.06 0 -2.05 1.0E-5 TargetScan -0.17 0.04523 NA
145 hsa-miR-200b-3p DIXDC1 2.06 0 -1.16 0 TargetScan -0.49 0 NA
146 hsa-miR-200b-3p DLC1 2.06 0 -0.38 0.05038 TargetScan -0.32 0 NA
147 hsa-miR-192-5p DLG5 2.09 0 0.26 0.06322 miRNAWalker2 validate -0.13 0 NA
148 hsa-miR-200a-3p DLX5 2.02 0 0.47 0.22977 miRNAWalker2 validate; miRTarBase -0.27 2.0E-5 NA
149 hsa-miR-200b-3p DMD 2.06 0 -1.51 0 TargetScan -0.6 0 NA
150 hsa-miR-21-5p DMD 2.22 0 -1.51 0 miRNAWalker2 validate -0.81 0 NA

Over-represented Gene Ontology Biological Process

NumGOOverlapSizeP ValueAdj. P Value
1 CELL DEVELOPMENT 136 1426 8.068e-25 3.754e-21
2 REGULATION OF MULTICELLULAR ORGANISMAL DEVELOPMENT 146 1672 7.147e-23 1.663e-19
3 CARDIOVASCULAR SYSTEM DEVELOPMENT 91 788 3.949e-22 4.593e-19
4 CIRCULATORY SYSTEM DEVELOPMENT 91 788 3.949e-22 4.593e-19
5 CELL MORPHOGENESIS INVOLVED IN DIFFERENTIATION 71 513 7.641e-22 7.111e-19
6 TISSUE DEVELOPMENT 134 1518 2.358e-21 1.829e-18
7 NEUROGENESIS 127 1402 3.556e-21 2.364e-18
8 REGULATION OF CELL DIFFERENTIATION 132 1492 4.101e-21 2.385e-18
9 CELLULAR COMPONENT MORPHOGENESIS 94 900 8.788e-20 4.543e-17
10 REGULATION OF ANATOMICAL STRUCTURE MORPHOGENESIS 101 1021 1.615e-19 7.512e-17
11 MOVEMENT OF CELL OR SUBCELLULAR COMPONENT 116 1275 1.783e-19 7.542e-17
12 REGULATION OF CELL DEVELOPMENT 87 836 3.002e-18 1.164e-15
13 REGULATION OF PHOSPHORUS METABOLIC PROCESS 132 1618 4.332e-18 1.55e-15
14 REGULATION OF NEURON DIFFERENTIATION 67 554 1.614e-17 5.366e-15
15 REGULATION OF NERVOUS SYSTEM DEVELOPMENT 79 750 6.168e-17 1.913e-14
16 REGULATION OF CELLULAR COMPONENT MOVEMENT 80 771 9.2e-17 2.675e-14
17 CELLULAR RESPONSE TO ENDOGENOUS STIMULUS 94 1008 1.595e-16 4.365e-14
18 RESPONSE TO ENDOGENOUS STIMULUS 119 1450 1.697e-16 4.388e-14
19 REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 136 1784 3.51e-16 8.596e-14
20 VASCULATURE DEVELOPMENT 58 469 9.673e-16 2.25e-13
21 LOCOMOTION 98 1114 1.516e-15 3.359e-13
22 REGULATION OF CELL MORPHOGENESIS 62 552 9.075e-15 1.919e-12
23 ORGAN MORPHOGENESIS 80 841 1.222e-14 2.443e-12
24 REGULATION OF PROTEIN MODIFICATION PROCESS 128 1710 1.26e-14 2.443e-12
25 EPITHELIUM DEVELOPMENT 86 945 1.468e-14 2.732e-12
26 POSITIVE REGULATION OF DEVELOPMENTAL PROCESS 97 1142 1.949e-14 3.488e-12
27 TISSUE MORPHOGENESIS 60 533 2.269e-14 3.911e-12
28 NEURON PROJECTION DEVELOPMENT 60 545 6.13e-14 1.019e-11
29 NEURON PROJECTION MORPHOGENESIS 50 402 7.948e-14 1.275e-11
30 CENTRAL NERVOUS SYSTEM DEVELOPMENT 80 872 8.677e-14 1.346e-11
31 POSITIVE REGULATION OF CELL DIFFERENTIATION 77 823 9.569e-14 1.436e-11
32 HEART DEVELOPMENT 54 466 1.472e-13 2.141e-11
33 CELL PROJECTION ORGANIZATION 81 902 1.893e-13 2.668e-11
34 ENZYME LINKED RECEPTOR PROTEIN SIGNALING PATHWAY 68 689 2.457e-13 3.299e-11
35 POSITIVE REGULATION OF CELL DEVELOPMENT 54 472 2.481e-13 3.299e-11
36 NEURON DIFFERENTIATION 79 874 2.75e-13 3.554e-11
37 POSITIVE REGULATION OF NEURON DIFFERENTIATION 42 306 2.994e-13 3.765e-11
38 REGULATION OF NEURON PROJECTION DEVELOPMENT 49 408 5.386e-13 6.595e-11
39 REGULATION OF CELL PROJECTION ORGANIZATION 59 558 5.731e-13 6.837e-11
40 NEURON DEVELOPMENT 67 687 6.489e-13 7.548e-11
41 CELL MORPHOGENESIS INVOLVED IN NEURON DIFFERENTIATION 46 368 6.762e-13 7.674e-11
42 NEGATIVE REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 70 740 8.248e-13 9.137e-11
43 POSITIVE REGULATION OF PHOSPHATE METABOLIC PROCESS 87 1036 9.492e-13 9.762e-11
44 MORPHOGENESIS OF AN EPITHELIUM 48 400 9.651e-13 9.762e-11
45 REGULATION OF INTRACELLULAR SIGNAL TRANSDUCTION 120 1656 9.409e-13 9.762e-11
46 POSITIVE REGULATION OF PHOSPHORUS METABOLIC PROCESS 87 1036 9.492e-13 9.762e-11
47 RESPONSE TO GROWTH FACTOR 53 475 1.124e-12 1.113e-10
48 TUBE DEVELOPMENT 58 552 1.183e-12 1.147e-10
49 UROGENITAL SYSTEM DEVELOPMENT 40 299 2.556e-12 2.427e-10
50 HEAD DEVELOPMENT 67 709 2.76e-12 2.568e-10
51 POSITIVE REGULATION OF MULTICELLULAR ORGANISMAL PROCESS 105 1395 3.259e-12 2.94e-10
52 REGULATION OF CELL DEATH 109 1472 3.285e-12 2.94e-10
53 CELL PART MORPHOGENESIS 62 633 4.122e-12 3.618e-10
54 CELL MOTILITY 74 835 4.338e-12 3.67e-10
55 LOCALIZATION OF CELL 74 835 4.338e-12 3.67e-10
56 ACTIN FILAMENT BASED PROCESS 50 450 5.856e-12 4.866e-10
57 CELLULAR RESPONSE TO ORGANIC SUBSTANCE 127 1848 7.306e-12 5.964e-10
58 TUBE MORPHOGENESIS 41 323 7.556e-12 6.062e-10
59 INTRACELLULAR SIGNAL TRANSDUCTION 113 1572 8.19e-12 6.459e-10
60 POSITIVE REGULATION OF BIOSYNTHETIC PROCESS 124 1805 1.399e-11 1.085e-09
61 RESPONSE TO HORMONE 76 893 1.571e-11 1.198e-09
62 POSITIVE REGULATION OF CELL PROJECTION ORGANIZATION 39 303 1.608e-11 1.207e-09
63 POSITIVE REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 82 1004 1.893e-11 1.398e-09
64 POSITIVE REGULATION OF CELLULAR COMPONENT ORGANIZATION 90 1152 1.983e-11 1.441e-09
65 NEGATIVE REGULATION OF NITROGEN COMPOUND METABOLIC PROCESS 109 1517 2.102e-11 1.504e-09
66 POSITIVE REGULATION OF CATALYTIC ACTIVITY 109 1518 2.187e-11 1.542e-09
67 POSITIVE REGULATION OF NERVOUS SYSTEM DEVELOPMENT 48 437 2.365e-11 1.642e-09
68 ANATOMICAL STRUCTURE FORMATION INVOLVED IN MORPHOGENESIS 79 957 2.725e-11 1.865e-09
69 REGULATION OF CELL MORPHOGENESIS INVOLVED IN DIFFERENTIATION 41 337 2.943e-11 1.984e-09
70 PROTEIN PHOSPHORYLATION 78 944 3.518e-11 2.339e-09
71 EMBRYO DEVELOPMENT 75 894 4.262e-11 2.793e-09
72 EMBRYONIC MORPHOGENESIS 54 539 4.557e-11 2.945e-09
73 CELLULAR RESPONSE TO OXYGEN CONTAINING COMPOUND 69 799 7.672e-11 4.824e-09
74 POSITIVE REGULATION OF MOLECULAR FUNCTION 121 1791 7.616e-11 4.824e-09
75 NEGATIVE REGULATION OF GENE EXPRESSION 106 1493 8.384e-11 5.201e-09
76 NEGATIVE REGULATION OF DEVELOPMENTAL PROCESS 69 801 8.565e-11 5.244e-09
77 MESENCHYME DEVELOPMENT 29 190 1.126e-10 6.802e-09
78 REGULATION OF KINASE ACTIVITY 67 776 1.484e-10 8.854e-09
79 POSITIVE REGULATION OF GENE EXPRESSION 117 1733 1.742e-10 1.026e-08
80 DENDRITE MORPHOGENESIS 14 42 1.824e-10 1.048e-08
81 POSITIVE REGULATION OF NEURON PROJECTION DEVELOPMENT 32 232 1.823e-10 1.048e-08
82 REGULATION OF CELL PROLIFERATION 105 1496 2.018e-10 1.145e-08
83 REGULATION OF CELL ADHESION 58 629 2.267e-10 1.271e-08
84 NEGATIVE REGULATION OF MULTICELLULAR ORGANISMAL PROCESS 78 983 2.416e-10 1.338e-08
85 BLOOD VESSEL MORPHOGENESIS 41 364 3.245e-10 1.776e-08
86 DENDRITE DEVELOPMENT 18 79 5.303e-10 2.804e-08
87 NEGATIVE REGULATION OF CELL DIFFERENTIATION 56 609 5.211e-10 2.804e-08
88 NEGATIVE REGULATION OF CELL PROLIFERATION 58 643 5.273e-10 2.804e-08
89 POSITIVE REGULATION OF PROTEIN MODIFICATION PROCESS 85 1135 6.228e-10 3.256e-08
90 REGULATION OF SMALL GTPASE MEDIATED SIGNAL TRANSDUCTION 34 278 1.273e-09 6.581e-08
91 REGULATION OF CELL SUBSTRATE ADHESION 26 173 1.454e-09 7.436e-08
92 RESPONSE TO OXYGEN CONTAINING COMPOUND 96 1381 2.219e-09 1.122e-07
93 BEHAVIOR 49 516 2.262e-09 1.132e-07
94 POSITIVE REGULATION OF LOCOMOTION 43 420 2.356e-09 1.166e-07
95 CELLULAR RESPONSE TO HORMONE STIMULUS 51 552 2.7e-09 1.322e-07
96 REGULATION OF TRANSFERASE ACTIVITY 73 946 3.184e-09 1.543e-07
97 BRANCHING MORPHOGENESIS OF AN EPITHELIAL TUBE 22 131 3.219e-09 1.544e-07
98 MORPHOGENESIS OF A BRANCHING STRUCTURE 25 167 3.265e-09 1.55e-07
99 DEVELOPMENTAL GROWTH 37 333 3.484e-09 1.637e-07
100 BONE DEVELOPMENT 24 156 3.855e-09 1.794e-07
101 SINGLE ORGANISM BEHAVIOR 40 384 5.248e-09 2.418e-07
102 TRANSMEMBRANE RECEPTOR PROTEIN TYROSINE KINASE SIGNALING PATHWAY 47 498 5.894e-09 2.689e-07
103 NEGATIVE REGULATION OF CELL COMMUNICATION 85 1192 6.395e-09 2.889e-07
104 REGULATION OF ACTIN FILAMENT BASED PROCESS 35 312 7.22e-09 3.23e-07
105 POSITIVE REGULATION OF CELL MORPHOGENESIS INVOLVED IN DIFFERENTIATION 24 162 8.301e-09 3.678e-07
106 SKELETAL SYSTEM DEVELOPMENT 44 455 8.79e-09 3.858e-07
107 REGULATION OF EPITHELIAL CELL PROLIFERATION 33 285 8.88e-09 3.862e-07
108 REGULATION OF SYSTEM PROCESS 47 507 1.037e-08 4.466e-07
109 GROWTH 41 410 1.1e-08 4.694e-07
110 POSITIVE REGULATION OF CELL COMMUNICATION 101 1532 1.294e-08 5.472e-07
111 REGULATION OF EPITHELIAL CELL MIGRATION 24 166 1.355e-08 5.679e-07
112 EPITHELIAL CELL DIFFERENTIATION 46 495 1.384e-08 5.749e-07
113 RESPONSE TO WOUNDING 50 563 1.422e-08 5.856e-07
114 POSITIVE REGULATION OF KINASE ACTIVITY 45 482 1.734e-08 7.018e-07
115 REGULATION OF AXONOGENESIS 24 168 1.72e-08 7.018e-07
116 RESPONSE TO ABIOTIC STIMULUS 75 1024 1.785e-08 7.162e-07
117 NEGATIVE REGULATION OF RESPONSE TO STIMULUS 92 1360 1.87e-08 7.437e-07
118 COGNITION 30 251 2.037e-08 8.031e-07
119 REGULATION OF WNT SIGNALING PATHWAY 34 310 2.088e-08 8.165e-07
120 WOUND HEALING 44 470 2.312e-08 8.964e-07
121 MESENCHYMAL CELL DIFFERENTIATION 21 134 2.589e-08 9.956e-07
122 REGULATION OF CELLULAR RESPONSE TO GROWTH FACTOR STIMULUS 28 229 3.684e-08 1.405e-06
123 KIDNEY EPITHELIUM DEVELOPMENT 20 125 3.878e-08 1.467e-06
124 TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 58 724 3.995e-08 1.487e-06
125 NEGATIVE REGULATION OF CELL DEATH 66 872 3.988e-08 1.487e-06
126 METANEPHROS DEVELOPMENT 16 81 4.257e-08 1.572e-06
127 REGULATION OF DEVELOPMENTAL GROWTH 32 289 4.341e-08 1.591e-06
128 STEM CELL DIFFERENTIATION 25 190 4.641e-08 1.687e-06
129 REGULATION OF TRANSPORT 112 1804 4.918e-08 1.774e-06
130 NEPHRON DEVELOPMENT 19 115 4.974e-08 1.78e-06
131 POSITIVE REGULATION OF PROTEIN METABOLIC PROCESS 97 1492 5.149e-08 1.815e-06
132 PHOSPHORYLATION 84 1228 5.121e-08 1.815e-06
133 BIOLOGICAL ADHESION 74 1032 5.326e-08 1.863e-06
134 NEGATIVE REGULATION OF LOCOMOTION 30 263 5.894e-08 2.047e-06
135 REGULATION OF MAPK CASCADE 54 660 5.991e-08 2.065e-06
136 AMEBOIDAL TYPE CELL MIGRATION 22 154 6.749e-08 2.309e-06
137 CONNECTIVE TISSUE DEVELOPMENT 25 194 7.031e-08 2.388e-06
138 TISSUE MIGRATION 16 84 7.291e-08 2.458e-06
139 PHOSPHATE CONTAINING COMPOUND METABOLIC PROCESS 119 1977 9.522e-08 3.166e-06
140 RESPIRATORY SYSTEM DEVELOPMENT 25 197 9.525e-08 3.166e-06
141 REGULATION OF HYDROLASE ACTIVITY 88 1327 9.673e-08 3.192e-06
142 CYTOSKELETON ORGANIZATION 63 838 1.052e-07 3.447e-06
143 CELL JUNCTION ORGANIZATION 24 185 1.128e-07 3.664e-06
144 REGULATION OF GTPASE ACTIVITY 54 673 1.134e-07 3.664e-06
145 RESPONSE TO ORGANIC CYCLIC COMPOUND 67 917 1.187e-07 3.809e-06
146 RENAL TUBULE DEVELOPMENT 15 78 1.632e-07 5.2e-06
147 NEGATIVE REGULATION OF INTRACELLULAR SIGNAL TRANSDUCTION 40 437 1.843e-07 5.834e-06
148 MESONEPHROS DEVELOPMENT 16 90 1.989e-07 6.252e-06
149 REGULATION OF PHOSPHATIDYLINOSITOL 3 KINASE SIGNALING 20 138 2.085e-07 6.502e-06
150 CELL SUBSTRATE ADHESION 22 164 2.096e-07 6.502e-06
151 POSITIVE REGULATION OF TRANSFERASE ACTIVITY 50 616 2.39e-07 7.364e-06
152 POSITIVE REGULATION OF RESPONSE TO STIMULUS 115 1929 2.682e-07 8.209e-06
153 RESPONSE TO ALCOHOL 35 362 2.967e-07 9.024e-06
154 CELL JUNCTION ASSEMBLY 19 129 3.236e-07 9.729e-06
155 KIDNEY MORPHOGENESIS 15 82 3.241e-07 9.729e-06
156 POSITIVE REGULATION OF CELL DEATH 49 605 3.373e-07 1.006e-05
157 POSITIVE REGULATION OF HYDROLASE ACTIVITY 65 905 3.418e-07 1.013e-05
158 ACTION POTENTIAL 16 94 3.699e-07 1.089e-05
159 NEGATIVE REGULATION OF CELL DEVELOPMENT 31 303 4.149e-07 1.214e-05
160 RESPONSE TO TRANSFORMING GROWTH FACTOR BETA 20 144 4.217e-07 1.219e-05
161 REGULATION OF ORGAN MORPHOGENESIS 27 242 4.207e-07 1.219e-05
162 REGULATION OF PROTEIN SERINE THREONINE KINASE ACTIVITY 41 470 4.664e-07 1.34e-05
163 REGULATION OF CELLULAR COMPONENT SIZE 33 337 4.842e-07 1.382e-05
164 NEGATIVE REGULATION OF PHOSPHORUS METABOLIC PROCESS 45 541 4.922e-07 1.388e-05
165 NEGATIVE REGULATION OF PHOSPHATE METABOLIC PROCESS 45 541 4.922e-07 1.388e-05
166 NEGATIVE REGULATION OF PHOSPHORYLATION 38 422 5.623e-07 1.576e-05
167 SYSTEM PROCESS 107 1785 5.774e-07 1.609e-05
168 NEGATIVE REGULATION OF NERVOUS SYSTEM DEVELOPMENT 28 262 6.239e-07 1.718e-05
169 FOREBRAIN DEVELOPMENT 34 357 6.209e-07 1.718e-05
170 REGULATION OF CELLULAR COMPONENT BIOGENESIS 57 767 6.334e-07 1.734e-05
171 CARDIAC MUSCLE CELL CONTRACTION 9 29 6.893e-07 1.876e-05
172 CARDIAC MUSCLE CELL ACTION POTENTIAL 10 37 6.937e-07 1.877e-05
173 RESPONSE TO OXYGEN LEVELS 31 311 7.318e-07 1.968e-05
174 NEURON PROJECTION GUIDANCE 24 205 7.678e-07 2.053e-05
175 NEGATIVE REGULATION OF NEURON DIFFERENTIATION 23 191 7.911e-07 2.103e-05
176 POSITIVE REGULATION OF CELL PROLIFERATION 59 814 9.078e-07 2.4e-05
177 REGULATION OF EXTENT OF CELL GROWTH 16 101 1.011e-06 2.657e-05
178 POSITIVE REGULATION OF EPITHELIAL CELL MIGRATION 16 103 1.324e-06 3.461e-05
179 POSITIVE REGULATION OF AXONOGENESIS 13 69 1.389e-06 3.611e-05
180 REGULATION OF PROTEIN IMPORT 22 183 1.407e-06 3.637e-05
181 REGULATION OF RAS PROTEIN SIGNAL TRANSDUCTION 22 184 1.543e-06 3.966e-05
182 NEPHRON EPITHELIUM DEVELOPMENT 15 93 1.735e-06 4.435e-05
183 CELL SUBSTRATE JUNCTION ASSEMBLY 10 41 1.95e-06 4.959e-05
184 REGULATION OF MEMBRANE POTENTIAL 32 343 2.066e-06 5.223e-05
185 RESPONSE TO NITROGEN COMPOUND 60 859 2.423e-06 6.093e-05
186 CARTILAGE DEVELOPMENT 19 147 2.466e-06 6.17e-05
187 MUSCLE STRUCTURE DEVELOPMENT 37 432 2.604e-06 6.48e-05
188 REGULATION OF NUCLEOCYTOPLASMIC TRANSPORT 24 220 2.725e-06 6.743e-05
189 NEGATIVE REGULATION OF CELL CYCLE 37 433 2.748e-06 6.766e-05
190 REGULATION OF RHO PROTEIN SIGNAL TRANSDUCTION 16 109 2.856e-06 6.994e-05
191 REGULATION OF CANONICAL WNT SIGNALING PATHWAY 25 236 2.897e-06 7.057e-05
192 CELLULAR RESPONSE TO NITROGEN COMPOUND 41 505 2.919e-06 7.073e-05
193 POSITIVE REGULATION OF MAPK CASCADE 39 470 3.024e-06 7.287e-05
194 CELL PROLIFERATION 50 672 3.038e-06 7.287e-05
195 MODULATION OF SYNAPTIC TRANSMISSION 29 301 3.28e-06 7.826e-05
196 NEGATIVE REGULATION OF CELL SUBSTRATE ADHESION 11 53 3.333e-06 7.908e-05
197 REGULATION OF ANATOMICAL STRUCTURE SIZE 39 472 3.348e-06 7.908e-05
198 SINGLE ORGANISM CELL ADHESION 38 459 4.267e-06 0.0001003
199 CENTRAL NERVOUS SYSTEM NEURON AXONOGENESIS 8 27 4.308e-06 0.0001007
200 LUNG MORPHOGENESIS 10 45 4.848e-06 0.0001128
201 CELL CYCLE ARREST 19 154 4.952e-06 0.0001146
202 MUSCLE TISSUE DEVELOPMENT 27 275 5e-06 0.0001152
203 ENDOTHELIUM DEVELOPMENT 14 90 5.929e-06 0.0001359
204 POSITIVE REGULATION OF DEVELOPMENTAL GROWTH 19 156 5.994e-06 0.0001367
205 REGULATION OF GROWTH 47 633 6.369e-06 0.0001446
206 REGULATION OF CELLULAR LOCALIZATION 79 1277 6.585e-06 0.0001487
207 PEPTIDYL TYROSINE MODIFICATION 21 186 6.614e-06 0.0001487
208 REGULATION OF CELL SIZE 20 172 6.992e-06 0.0001564
209 NEGATIVE REGULATION OF CELL PROJECTION ORGANIZATION 18 144 7.267e-06 0.0001618
210 REGULATION OF PROTEIN LOCALIZATION TO NUCLEUS 23 218 7.658e-06 0.0001697
211 MUSCLE SYSTEM PROCESS 27 282 7.968e-06 0.0001757
212 IMMUNE SYSTEM DEVELOPMENT 44 582 8.021e-06 0.0001761
213 SUBSTRATE ADHESION DEPENDENT CELL SPREADING 9 38 8.298e-06 0.0001813
214 ACTIN FILAMENT BASED MOVEMENT 14 93 8.774e-06 0.0001908
215 CELLULAR RESPONSE TO ACID CHEMICAL 20 175 9.082e-06 0.0001966
216 SENSORY ORGAN DEVELOPMENT 39 493 9.333e-06 0.0002011
217 CENTRAL NERVOUS SYSTEM NEURON DEVELOPMENT 12 70 9.817e-06 0.0002105
218 CELL MIGRATION INVOLVED IN SPROUTING ANGIOGENESIS 6 15 9.974e-06 0.0002121
219 VASCULOGENESIS 11 59 9.982e-06 0.0002121
220 CENTRAL NERVOUS SYSTEM PROJECTION NEURON AXONOGENESIS 7 22 1.029e-05 0.0002176
221 REGULATION OF SMOOTH MUSCLE CELL MIGRATION 10 49 1.091e-05 0.0002297
222 ENDOTHELIAL CELL DIFFERENTIATION 12 72 1.324e-05 0.0002763
223 TAXIS 37 464 1.322e-05 0.0002763
224 NEGATIVE REGULATION OF DEVELOPMENTAL GROWTH 13 84 1.344e-05 0.0002789
225 RESPONSE TO LIPID 59 888 1.349e-05 0.0002789
226 CELLULAR RESPONSE TO PEPTIDE 26 274 1.368e-05 0.0002816
227 REGULATION OF CYTOSKELETON ORGANIZATION 39 502 1.414e-05 0.0002899
228 HINDBRAIN DEVELOPMENT 17 137 1.429e-05 0.0002917
229 HEART PROCESS 13 85 1.533e-05 0.0003115
230 INOSITOL LIPID MEDIATED SIGNALING 16 124 1.547e-05 0.0003129
231 HEART MORPHOGENESIS 22 212 1.56e-05 0.0003143
232 ANGIOGENESIS 27 293 1.598e-05 0.0003191
233 TELENCEPHALON DEVELOPMENT 23 228 1.598e-05 0.0003191
234 MEMORY 14 98 1.625e-05 0.0003231
235 PALLIUM DEVELOPMENT 18 153 1.693e-05 0.0003352
236 REGULATION OF CELL SHAPE 17 139 1.732e-05 0.0003416
237 ACTIN MEDIATED CELL CONTRACTION 12 74 1.767e-05 0.0003468
238 REGULATION OF BLOOD CIRCULATION 27 295 1.805e-05 0.0003528
239 LIPID PHOSPHORYLATION 14 99 1.828e-05 0.000356
240 REGULATION OF CARTILAGE DEVELOPMENT 11 63 1.917e-05 0.0003717
241 PATTERN SPECIFICATION PROCESS 34 418 1.957e-05 0.0003778
242 MESONEPHRIC TUBULE MORPHOGENESIS 10 53 2.262e-05 0.000435
243 RENAL SYSTEM PROCESS 14 102 2.58e-05 0.0004941
244 EMBRYO DEVELOPMENT ENDING IN BIRTH OR EGG HATCHING 41 554 2.671e-05 0.0005072
245 REGULATION OF ACTIN FILAMENT BUNDLE ASSEMBLY 12 77 2.671e-05 0.0005072
246 PLATELET DERIVED GROWTH FACTOR RECEPTOR SIGNALING PATHWAY 8 34 2.794e-05 0.0005222
247 RESPONSE TO FLUID SHEAR STRESS 8 34 2.794e-05 0.0005222
248 RENAL WATER HOMEOSTASIS 8 34 2.794e-05 0.0005222
249 NEGATIVE REGULATION OF GROWTH 23 236 2.778e-05 0.0005222
250 REGULATION OF CELL MATRIX ADHESION 13 90 2.873e-05 0.0005348
251 REGULATION OF TRANSMEMBRANE TRANSPORT 34 426 2.886e-05 0.000535
252 REGULATION OF HEART CONTRACTION 22 221 2.98e-05 0.0005502
253 SOMATIC STEM CELL POPULATION MAINTENANCE 11 66 3.021e-05 0.0005556
254 TRANSMEMBRANE RECEPTOR PROTEIN SERINE THREONINE KINASE SIGNALING PATHWAY 20 190 3.056e-05 0.0005598
255 LEARNING 16 131 3.092e-05 0.0005643
256 DEVELOPMENTAL GROWTH INVOLVED IN MORPHOGENESIS 14 104 3.222e-05 0.0005833
257 NEGATIVE REGULATION OF PROTEIN MODIFICATION PROCESS 44 616 3.216e-05 0.0005833
258 SMOOTH MUSCLE TISSUE DEVELOPMENT 6 18 3.36e-05 0.000606
259 REGULATION OF TRANSMEMBRANE RECEPTOR PROTEIN SERINE THREONINE KINASE SIGNALING PATHWAY 21 207 3.394e-05 0.0006097
260 POSITIVE REGULATION OF INTRACELLULAR SIGNAL TRANSDUCTION 57 876 3.413e-05 0.0006107
261 ENDOTHELIAL CELL DEVELOPMENT 9 45 3.57e-05 0.0006364
262 NEGATIVE REGULATION OF CANONICAL WNT SIGNALING PATHWAY 18 162 3.679e-05 0.0006528
263 GLAND DEVELOPMENT 32 395 3.69e-05 0.0006528
264 CELL MATRIX ADHESION 15 119 3.744e-05 0.0006574
265 REGULATION OF DENDRITIC SPINE DEVELOPMENT 10 56 3.734e-05 0.0006574
266 REGULATION OF BODY FLUID LEVELS 38 506 3.82e-05 0.0006683
267 NEGATIVE REGULATION OF PROTEIN METABOLIC PROCESS 67 1087 3.846e-05 0.0006702
268 REGULATION OF INTRACELLULAR TRANSPORT 44 621 3.895e-05 0.0006763
269 PEPTIDYL SERINE MODIFICATION 17 148 3.929e-05 0.0006796
270 REGULATION OF CELL JUNCTION ASSEMBLY 11 68 4.029e-05 0.0006918
271 ORGAN GROWTH 11 68 4.029e-05 0.0006918
272 POSITIVE REGULATION OF CHEMOTAXIS 15 120 4.134e-05 0.0007071
273 REGULATION OF CHONDROCYTE DIFFERENTIATION 9 46 4.293e-05 0.0007316
274 POSITIVE REGULATION OF AXON EXTENSION 8 36 4.36e-05 0.0007403
275 ENDOTHELIAL CELL MIGRATION 10 57 4.379e-05 0.000741
276 REGULATION OF MUSCLE SYSTEM PROCESS 20 195 4.436e-05 0.0007478
277 REGULATION OF CATENIN IMPORT INTO NUCLEUS 7 27 4.551e-05 0.0007645
278 RESPONSE TO BMP 13 94 4.592e-05 0.0007659
279 CELLULAR RESPONSE TO BMP STIMULUS 13 94 4.592e-05 0.0007659
280 CENTRAL NERVOUS SYSTEM NEURON DIFFERENTIATION 18 166 5.09e-05 0.0008458
281 CIRCULATORY SYSTEM PROCESS 30 366 5.169e-05 0.0008498
282 CELLULAR RESPONSE TO LIPID 35 457 5.168e-05 0.0008498
283 POSITIVE REGULATION OF RESPONSE TO EXTERNAL STIMULUS 26 296 5.164e-05 0.0008498
284 MULTICELLULAR ORGANISMAL SIGNALING 15 123 5.525e-05 0.0009053
285 RESPONSE TO PEPTIDE 32 404 5.689e-05 0.0009289
286 WNT SIGNALING PATHWAY 29 351 5.952e-05 0.0009684
287 REGULATION OF ESTABLISHMENT OF PLANAR POLARITY 14 110 6.057e-05 0.000982
288 NEGATIVE REGULATION OF NUCLEOCYTOPLASMIC TRANSPORT 11 71 6.08e-05 0.0009823
289 REGULATION OF SODIUM ION TRANSMEMBRANE TRANSPORT 9 48 6.113e-05 0.0009842
290 EMBRYONIC ORGAN DEVELOPMENT 32 406 6.249e-05 0.001003
291 POSITIVE REGULATION OF EPITHELIAL CELL PROLIFERATION 17 154 6.519e-05 0.001042
292 LYMPH VESSEL DEVELOPMENT 6 20 6.581e-05 0.001049
293 RESPONSE TO ACID CHEMICAL 27 319 7.052e-05 0.00112
294 PHOSPHATIDYLINOSITOL 3 PHOSPHATE BIOSYNTHETIC PROCESS 9 49 7.243e-05 0.001141
295 GLOMERULUS DEVELOPMENT 9 49 7.243e-05 0.001141
296 OSSIFICATION 23 251 7.256e-05 0.001141
297 PALATE DEVELOPMENT 12 85 7.281e-05 0.001141
298 REGULATION OF ORGAN GROWTH 11 73 7.897e-05 0.001233
299 POSITIVE REGULATION OF CELL ADHESION 30 376 8.436e-05 0.001309
300 RESPONSE TO DRUG 33 431 8.441e-05 0.001309
301 REGULATION OF ADHERENS JUNCTION ORGANIZATION 9 50 8.543e-05 0.001321
302 NEGATIVE REGULATION OF ORGAN GROWTH 6 21 8.923e-05 0.001373
303 MYELOID CELL DIFFERENTIATION 19 189 8.943e-05 0.001373
304 REGULATION OF EMBRYONIC DEVELOPMENT 14 114 8.985e-05 0.001375
305 REGULATION OF ERK1 AND ERK2 CASCADE 22 238 9.093e-05 0.001383
306 POSITIVE REGULATION OF GROWTH 22 238 9.093e-05 0.001383
307 SMOOTH MUSCLE CELL DIFFERENTIATION 7 30 9.462e-05 0.001425
308 POSITIVE REGULATION OF SMOOTH MUSCLE CELL MIGRATION 7 30 9.462e-05 0.001425
309 REGULATION OF DENDRITIC SPINE MORPHOGENESIS 7 30 9.462e-05 0.001425
310 CALCIUM ION TRANSMEMBRANE TRANSPORT 17 159 9.725e-05 0.00146
311 NEGATIVE REGULATION OF MOLECULAR FUNCTION 65 1079 9.843e-05 0.001473
312 ARTERY DEVELOPMENT 11 75 0.0001016 0.00151
313 POSITIVE REGULATION OF CYTOSKELETON ORGANIZATION 18 175 0.0001014 0.00151
314 SECOND MESSENGER MEDIATED SIGNALING 17 160 0.0001051 0.001558
315 SYNAPSE ORGANIZATION 16 145 0.0001065 0.001573
316 LEUKOCYTE DIFFERENTIATION 25 292 0.0001077 0.001587
317 MEMBRANE DEPOLARIZATION DURING CARDIAC MUSCLE CELL ACTION POTENTIAL 5 14 0.0001084 0.001591
318 REGULATION OF CATION TRANSMEMBRANE TRANSPORT 20 208 0.0001094 0.001601
319 REGULATION OF NEURON APOPTOTIC PROCESS 19 192 0.0001103 0.001604
320 PROTEIN AUTOPHOSPHORYLATION 19 192 0.0001103 0.001604
321 LUNG ALVEOLUS DEVELOPMENT 8 41 0.0001167 0.001692
322 PHOSPHATIDYLINOSITOL METABOLIC PROCESS 19 193 0.0001182 0.001708
323 BONE CELL DEVELOPMENT 6 22 0.0001188 0.001712
324 POSITIVE REGULATION OF DENDRITE DEVELOPMENT 10 64 0.0001214 0.001744
325 MAINTENANCE OF CELL NUMBER 15 132 0.0001245 0.00178
326 RESPONSE TO MECHANICAL STIMULUS 20 210 0.0001247 0.00178
327 REGULATION OF OSSIFICATION 18 178 0.000126 0.001793
328 ANTERIOR POSTERIOR PATTERN SPECIFICATION 19 194 0.0001266 0.001795
329 REGULATION OF BMP SIGNALING PATHWAY 11 77 0.0001295 0.001826
330 DEVELOPMENTAL CELL GROWTH 11 77 0.0001295 0.001826
331 REGULATION OF PEPTIDYL SERINE PHOSPHORYLATION 14 118 0.0001307 0.001832
332 MESODERM DEVELOPMENT 14 118 0.0001307 0.001832
333 REGULATION OF MORPHOGENESIS OF A BRANCHING STRUCTURE 9 53 0.0001367 0.001905
334 EMBRYONIC ORGAN MORPHOGENESIS 24 279 0.0001367 0.001905
335 REGULATION OF ORGANELLE ORGANIZATION 69 1178 0.0001387 0.001927
336 EPITHELIAL CELL MORPHOGENESIS 8 42 0.0001395 0.001932
337 REGULATION OF CYTOPLASMIC TRANSPORT 35 481 0.0001422 0.001964
338 POSITIVE REGULATION OF CELLULAR COMPONENT BIOGENESIS 31 406 0.0001441 0.001984
339 RHYTHMIC PROCESS 25 298 0.0001484 0.002037
340 NEGATIVE REGULATION OF WNT SIGNALING PATHWAY 19 197 0.0001548 0.002119
341 REGULATION OF DENDRITE DEVELOPMENT 14 120 0.0001566 0.002137
342 NEPHRIC DUCT DEVELOPMENT 5 15 0.0001576 0.002144
343 CELL GROWTH 15 135 0.0001604 0.002175
344 BONE MORPHOGENESIS 11 79 0.0001637 0.002215
345 AMINOGLYCAN METABOLIC PROCESS 17 166 0.000165 0.002226
346 AMINOGLYCAN BIOSYNTHETIC PROCESS 13 107 0.0001771 0.002382
347 REGULATION OF KIDNEY DEVELOPMENT 9 55 0.0001836 0.002462
348 BRANCHING INVOLVED IN URETERIC BUD MORPHOGENESIS 8 44 0.0001962 0.002623
349 BLOOD VESSEL ENDOTHELIAL CELL MIGRATION 6 24 0.0002011 0.002658
350 CARDIAC EPITHELIAL TO MESENCHYMAL TRANSITION 6 24 0.0002011 0.002658
351 POSITIVE REGULATION OF TRANSPORT 57 936 0.0002008 0.002658
352 SKELETAL SYSTEM MORPHOGENESIS 19 201 0.0002011 0.002658
353 EXTRACELLULAR STRUCTURE ORGANIZATION 25 304 0.0002021 0.002665
354 APPENDAGE DEVELOPMENT 17 169 0.0002049 0.002686
355 LIMB DEVELOPMENT 17 169 0.0002049 0.002686
356 CELL CELL ADHESION 41 608 0.0002056 0.002687
357 CELL DEATH 60 1001 0.0002086 0.002719
358 EPITHELIAL TO MESENCHYMAL TRANSITION 9 56 0.0002116 0.00275
359 LUNG EPITHELIUM DEVELOPMENT 7 34 0.0002196 0.002846
360 MEGAKARYOCYTE DEVELOPMENT 5 16 0.0002222 0.002864
361 NEGATIVE REGULATION OF STRESS FIBER ASSEMBLY 5 16 0.0002222 0.002864
362 REGULATION OF CYCLIC NUCLEOTIDE METABOLIC PROCESS 16 155 0.0002322 0.002965
363 POSITIVE REGULATION OF PROTEIN SERINE THREONINE KINASE ACTIVITY 24 289 0.0002326 0.002965
364 ENDOCHONDRAL BONE MORPHOGENESIS 8 45 0.0002308 0.002965
365 REGULATION OF CELLULAR PROTEIN LOCALIZATION 38 552 0.0002316 0.002965
366 REGULATION OF PROTEIN TARGETING 25 307 0.000235 0.002988
367 REGULATION OF SYNAPTIC PLASTICITY 15 140 0.0002401 0.003036
368 CARDIAC MUSCLE TISSUE DEVELOPMENT 15 140 0.0002401 0.003036
369 EYE DEVELOPMENT 26 326 0.0002468 0.003112
370 NEURAL PRECURSOR CELL PROLIFERATION 10 70 0.00026 0.003261
371 ESTABLISHMENT OR MAINTENANCE OF CELL POLARITY 15 141 0.0002596 0.003261
372 RESPONSE TO STEROID HORMONE 35 497 0.0002651 0.003315
373 POSITIVE REGULATION OF DENDRITIC SPINE DEVELOPMENT 7 35 0.0002657 0.003315
374 CYCLIC NUCLEOTIDE MEDIATED SIGNALING 8 46 0.0002704 0.003364
375 MULTICELLULAR ORGANISMAL WATER HOMEOSTASIS 9 58 0.0002783 0.003453
376 CALCIUM ION TRANSPORT 20 223 0.0002791 0.003453
377 REGIONALIZATION 25 311 0.0002861 0.003532
378 REGULATION OF PROTEIN LOCALIZATION 57 950 0.0002926 0.003601
379 CELLULAR RESPONSE TO OXYGEN LEVELS 15 143 0.0003028 0.003697
380 NEGATIVE REGULATION OF ANOIKIS 5 17 0.0003051 0.003697
381 MAMMARY GLAND ALVEOLUS DEVELOPMENT 5 17 0.0003051 0.003697
382 MAMMARY GLAND LOBULE DEVELOPMENT 5 17 0.0003051 0.003697
383 REGULATION OF PRI MIRNA TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 5 17 0.0003051 0.003697
384 ACTIVATION OF PROTEIN KINASE A ACTIVITY 5 17 0.0003051 0.003697
385 GLIOGENESIS 17 175 0.0003104 0.003744
386 REGULATION OF JNK CASCADE 16 159 0.0003106 0.003744
387 MUSCLE ORGAN DEVELOPMENT 23 277 0.000312 0.003751
388 STRIATED MUSCLE CONTRACTION 12 99 0.000318 0.003804
389 POSITIVE REGULATION OF CELL SUBSTRATE ADHESION 12 99 0.000318 0.003804
390 REPLACEMENT OSSIFICATION 6 26 0.0003228 0.003841
391 ENDOCHONDRAL OSSIFICATION 6 26 0.0003228 0.003841
392 CARDIAC CHAMBER DEVELOPMENT 15 144 0.0003266 0.003876
393 DEVELOPMENTAL PROCESS INVOLVED IN REPRODUCTION 40 602 0.0003303 0.00391
394 REGULATION OF ENDOTHELIAL CELL MIGRATION 13 114 0.0003338 0.003942
395 REGULATION OF CAMP METABOLIC PROCESS 14 129 0.0003354 0.003951
396 CELLULAR RESPONSE TO ORGANIC CYCLIC COMPOUND 33 465 0.0003427 0.004027
397 GLYCEROPHOSPHOLIPID METABOLIC PROCESS 24 297 0.0003479 0.004078
398 REGULATION OF HEART RATE 11 86 0.00035 0.004092
399 REGULATION OF LIPID KINASE ACTIVITY 8 48 0.0003662 0.00427
400 REGULATION OF NUCLEOTIDE METABOLIC PROCESS 19 211 0.0003733 0.004342
401 REGULATION OF CELL GROWTH 29 391 0.0003777 0.00438
402 GLIAL CELL MIGRATION 7 37 0.0003813 0.00438
403 REGULATION OF PROTEIN AUTOPHOSPHORYLATION 7 37 0.0003813 0.00438
404 AXON EXTENSION 7 37 0.0003813 0.00438
405 CAMP MEDIATED SIGNALING 7 37 0.0003813 0.00438
406 RESPONSE TO FIBROBLAST GROWTH FACTOR 13 116 0.000396 0.004538
407 HIPPO SIGNALING 6 27 0.000402 0.004596
408 REGULATION OF COLLATERAL SPROUTING 5 18 0.0004096 0.004637
409 REGULATION OF MUSCLE CONTRACTION 15 147 0.0004079 0.004637
410 RESPONSE TO PLATELET DERIVED GROWTH FACTOR 5 18 0.0004096 0.004637
411 REGULATION OF CELL CYCLE G1 S PHASE TRANSITION 15 147 0.0004079 0.004637
412 REGULATION OF MAP KINASE ACTIVITY 25 319 0.0004186 0.004728
413 ESTABLISHMENT OF CELL POLARITY 11 88 0.0004281 0.004823
414 NEGATIVE REGULATION OF CELL MORPHOGENESIS INVOLVED IN DIFFERENTIATION 13 117 0.0004306 0.004838
415 REGULATION OF CHEMOTAXIS 17 180 0.0004315 0.004838
416 DIGESTIVE SYSTEM DEVELOPMENT 15 148 0.0004386 0.004905
417 REGULATION OF STRESS ACTIVATED PROTEIN KINASE SIGNALING CASCADE 18 197 0.0004425 0.004937
418 REGULATION OF SODIUM ION TRANSMEMBRANE TRANSPORTER ACTIVITY 7 38 0.0004525 0.005037
419 REGULATION OF ION TRANSPORT 39 592 0.0004614 0.005124
420 REGULATION OF TRANSPORTER ACTIVITY 18 198 0.0004702 0.005209
421 REGULATION OF RESPONSE TO EXTERNAL STIMULUS 55 926 0.0004756 0.005256
422 RESPONSE TO KETONE 17 182 0.0004903 0.005406
423 MUSCLE CONTRACTION 20 233 0.0004928 0.005421
424 REGULATION OF CELL CYCLE 56 949 0.0004954 0.005426
425 REGULATION OF SPROUTING ANGIOGENESIS 6 28 0.0004956 0.005426
426 URETER DEVELOPMENT 4 11 0.0005163 0.005613
427 POSITIVE REGULATION OF ENDOTHELIAL CELL CHEMOTAXIS 4 11 0.0005163 0.005613
428 RESPONSE TO EXTERNAL STIMULUS 95 1821 0.0005142 0.005613
429 REGULATION OF PHOSPHOLIPASE C ACTIVITY 7 39 0.0005339 0.005777
430 MEMBRANE DEPOLARIZATION DURING ACTION POTENTIAL 7 39 0.0005339 0.005777
431 CELLULAR RESPONSE TO FLUID SHEAR STRESS 5 19 0.0005389 0.005777
432 REGULATION OF NON CANONICAL WNT SIGNALING PATHWAY 5 19 0.0005389 0.005777
433 NEGATIVE REGULATION OF ACTIN FILAMENT BUNDLE ASSEMBLY 5 19 0.0005389 0.005777
434 POSITIVE REGULATION OF CHONDROCYTE DIFFERENTIATION 5 19 0.0005389 0.005777
435 CEREBRAL CORTEX DEVELOPMENT 12 105 0.000548 0.005861
436 PHOSPHATIDYLINOSITOL BIOSYNTHETIC PROCESS 13 120 0.0005501 0.005871
437 RESPONSE TO ESTROGEN 19 218 0.0005597 0.00596
438 POSITIVE REGULATION OF ION TRANSPORT 20 236 0.0005799 0.00616
439 POSITIVE REGULATION OF WNT SIGNALING PATHWAY 15 152 0.0005819 0.006168
440 REGULATION OF CARDIAC MUSCLE CELL PROLIFERATION 6 29 0.0006053 0.006372
441 STEM CELL DIVISION 6 29 0.0006053 0.006372
442 POSITIVE REGULATION OF CARTILAGE DEVELOPMENT 6 29 0.0006053 0.006372
443 MUSCLE CELL DIFFERENTIATION 20 237 0.0006117 0.006425
444 REGULATION OF PHOSPHATIDYLINOSITOL 3 KINASE ACTIVITY 7 40 0.0006265 0.006551
445 NEGATIVE REGULATION OF SMALL GTPASE MEDIATED SIGNAL TRANSDUCTION 7 40 0.0006265 0.006551
446 EPITHELIAL CELL DEVELOPMENT 17 186 0.0006288 0.00656
447 CELLULAR RESPONSE TO IONIZING RADIATION 8 52 0.0006405 0.006667
448 NEGATIVE REGULATION OF AXONOGENESIS 9 65 0.0006623 0.006879
449 MEGAKARYOCYTE DIFFERENTIATION 5 20 0.0006966 0.007218
450 MUCOPOLYSACCHARIDE METABOLIC PROCESS 12 108 0.0007074 0.007315
451 GASTRULATION 15 155 0.0007141 0.007368
452 NEURON PROJECTION EXTENSION 8 53 0.00073 0.007431
453 POSITIVE REGULATION OF FIBROBLAST PROLIFERATION 8 53 0.00073 0.007431
454 AORTA DEVELOPMENT 7 41 0.0007315 0.007431
455 NEGATIVE REGULATION OF CELL MATRIX ADHESION 6 30 0.000733 0.007431
456 CYTOSOLIC CALCIUM ION TRANSPORT 8 53 0.00073 0.007431
457 NEGATIVE REGULATION OF EPITHELIAL CELL MIGRATION 8 53 0.00073 0.007431
458 REGULATION OF HEART RATE BY CARDIAC CONDUCTION 6 30 0.000733 0.007431
459 CELLULAR RESPONSE TO VASCULAR ENDOTHELIAL GROWTH FACTOR STIMULUS 6 30 0.000733 0.007431
460 NEGATIVE REGULATION OF CELL ADHESION 19 223 0.0007379 0.007464
461 REGULATION OF WNT SIGNALING PATHWAY PLANAR CELL POLARITY PATHWAY 4 12 0.0007517 0.00757
462 POSITIVE REGULATION OF GLUCOSE IMPORT IN RESPONSE TO INSULIN STIMULUS 4 12 0.0007517 0.00757
463 POSITIVE REGULATION OF MAP KINASE ACTIVITY 18 207 0.0007947 0.007986
464 NEGATIVE REGULATION OF INTRACELLULAR PROTEIN TRANSPORT 11 95 0.0008254 0.008277
465 POSITIVE REGULATION OF ENDOTHELIAL CELL MIGRATION 9 67 0.0008292 0.008297
466 FORMATION OF PRIMARY GERM LAYER 12 110 0.0008339 0.008309
467 NEURON MIGRATION 12 110 0.0008339 0.008309
468 NEGATIVE REGULATION OF BMP SIGNALING PATHWAY 7 42 0.0008499 0.00845
469 OSTEOBLAST DIFFERENTIATION 13 126 0.0008746 0.008658
470 NEGATIVE REGULATION OF PROTEIN SERINE THREONINE KINASE ACTIVITY 13 126 0.0008746 0.008658
471 CELLULAR RESPONSE TO OSMOTIC STRESS 5 21 0.0008863 0.008756
472 MYELOID LEUKOCYTE DIFFERENTIATION 11 96 0.0009014 0.008886
473 POSITIVE REGULATION OF ORGANELLE ORGANIZATION 37 573 0.000921 0.00906
474 LIPID MODIFICATION 18 210 0.0009388 0.009182
475 REGULATION OF POSTSYNAPTIC MEMBRANE POTENTIAL 8 55 0.0009393 0.009182
476 CARDIAC CONDUCTION 10 82 0.000939 0.009182
477 NEGATIVE REGULATION OF INTRACELLULAR TRANSPORT 14 143 0.0009475 0.009243
478 REGULATION OF OSTEOBLAST DIFFERENTIATION 12 112 0.0009788 0.009528
479 REGULATION OF CYCLIN DEPENDENT PROTEIN KINASE ACTIVITY 11 97 0.0009831 0.00955
480 REGULATION OF RESPONSE TO STRESS 78 1468 0.001 0.009696
481 SYNAPSE ASSEMBLY 9 69 0.001029 0.009951
NumGOOverlapSizeP ValueAdj. P Value
1 CYTOSKELETAL PROTEIN BINDING 70 819 8.775e-11 2.289e-08
2 TRANSCRIPTIONAL ACTIVATOR ACTIVITY RNA POLYMERASE II TRANSCRIPTION REGULATORY REGION SEQUENCE SPECIFIC BINDING 39 315 5.296e-11 2.289e-08
3 RNA POLYMERASE II TRANSCRIPTION FACTOR ACTIVITY SEQUENCE SPECIFIC DNA BINDING 60 629 2.772e-11 2.289e-08
4 MACROMOLECULAR COMPLEX BINDING 101 1399 9.857e-11 2.289e-08
5 NUCLEIC ACID BINDING TRANSCRIPTION FACTOR ACTIVITY 90 1199 1.63e-10 2.663e-08
6 TRANSCRIPTION FACTOR ACTIVITY RNA POLYMERASE II CORE PROMOTER PROXIMAL REGION SEQUENCE SPECIFIC BINDING 39 328 1.791e-10 2.663e-08
7 ENZYME BINDING 117 1737 2.007e-10 2.663e-08
8 PROTEIN KINASE ACTIVITY 58 640 4.412e-10 4.554e-08
9 TRANSCRIPTIONAL ACTIVATOR ACTIVITY RNA POLYMERASE II CORE PROMOTER PROXIMAL REGION SEQUENCE SPECIFIC BINDING 31 226 4.041e-10 4.554e-08
10 PROTEIN DOMAIN SPECIFIC BINDING 56 624 1.279e-09 1.188e-07
11 KINASE ACTIVITY 68 842 1.814e-09 1.532e-07
12 REGULATORY REGION NUCLEIC ACID BINDING 64 818 1.886e-08 1.46e-06
13 PDZ DOMAIN BINDING 17 90 3.256e-08 2.327e-06
14 MOLECULAR FUNCTION REGULATOR 90 1353 5.911e-08 3.922e-06
15 PROTEIN COMPLEX BINDING 68 935 1.131e-07 7.002e-06
16 TRANSFERASE ACTIVITY TRANSFERRING PHOSPHORUS CONTAINING GROUPS 70 992 2.299e-07 1.335e-05
17 ACTIN BINDING 37 393 2.655e-07 1.451e-05
18 SEQUENCE SPECIFIC DNA BINDING 72 1037 2.842e-07 1.467e-05
19 TRANSCRIPTION FACTOR ACTIVITY PROTEIN BINDING 48 588 3.541e-07 1.731e-05
20 KINASE BINDING 48 606 8.453e-07 3.926e-05
21 RAS GUANYL NUCLEOTIDE EXCHANGE FACTOR ACTIVITY 25 228 1.545e-06 6.834e-05
22 MICROTUBULE BINDING 23 201 1.934e-06 8.165e-05
23 PROTEIN SERINE THREONINE KINASE ACTIVITY 38 445 2.051e-06 8.284e-05
24 TRANSCRIPTION FACTOR ACTIVITY RNA POLYMERASE II TRANSCRIPTION FACTOR BINDING 18 133 2.317e-06 8.968e-05
25 DOUBLE STRANDED DNA BINDING 55 764 2.64e-06 9.81e-05
26 TRANSCRIPTION COREPRESSOR ACTIVITY 24 221 2.951e-06 0.0001054
27 GUANYL NUCLEOTIDE EXCHANGE FACTOR ACTIVITY 29 303 3.739e-06 0.000124
28 ION CHANNEL BINDING 16 111 3.643e-06 0.000124
29 TUBULIN BINDING 27 273 4.361e-06 0.0001397
30 TRANSCRIPTION FACTOR ACTIVITY RNA POLYMERASE II DISTAL ENHANCER SEQUENCE SPECIFIC BINDING 14 90 5.929e-06 0.0001836
31 PROTEIN TYROSINE KINASE ACTIVITY 20 176 9.895e-06 0.0002873
32 PHOSPHATIDYLINOSITOL 3 KINASE ACTIVITY 12 70 9.817e-06 0.0002873
33 PHOSPHATIDYLINOSITOL 3 KINASE BINDING 8 30 1.028e-05 0.0002895
34 CORE PROMOTER PROXIMAL REGION DNA BINDING 32 371 1.063e-05 0.0002904
35 TRANSCRIPTION FACTOR BINDING 40 524 1.653e-05 0.0004388
36 HISTONE DEACETYLASE BINDING 14 105 3.592e-05 0.0009268
37 TRANSMEMBRANE RECEPTOR PROTEIN KINASE ACTIVITY 12 81 4.485e-05 0.001126
38 CATION CHANNEL ACTIVITY 26 298 5.78e-05 0.001413
39 PROTEIN SERINE THREONINE TYROSINE KINASE ACTIVITY 8 39 8.028e-05 0.001912
40 HEPARIN BINDING 17 157 8.306e-05 0.001929
41 CHROMATIN BINDING 33 435 0.0001006 0.00228
42 METAL ION TRANSMEMBRANE TRANSPORTER ACTIVITY 32 417 0.0001032 0.002283
43 TRANSCRIPTIONAL REPRESSOR ACTIVITY RNA POLYMERASE II ACTIVATING TRANSCRIPTION FACTOR BINDING 9 53 0.0001367 0.002954
44 RHO GTPASE BINDING 11 78 0.0001458 0.003078
45 CYTOKINE BINDING 12 92 0.0001583 0.003197
46 PLATELET DERIVED GROWTH FACTOR RECEPTOR BINDING 5 15 0.0001576 0.003197
47 X1 PHOSPHATIDYLINOSITOL 3 KINASE ACTIVITY 8 43 0.0001659 0.003278
48 ACTIVATING TRANSCRIPTION FACTOR BINDING 9 57 0.000243 0.004704
49 BETA CATENIN BINDING 11 84 0.0002843 0.00539
50 IDENTICAL PROTEIN BINDING 69 1209 0.0002928 0.005441
51 CALCIUM ION TRANSMEMBRANE TRANSPORTER ACTIVITY 14 128 0.0003094 0.005636
52 TRANSCRIPTIONAL REPRESSOR ACTIVITY RNA POLYMERASE II TRANSCRIPTION FACTOR BINDING 11 86 0.00035 0.006254
53 RIBONUCLEOTIDE BINDING 97 1860 0.0004526 0.007933
54 SULFUR COMPOUND BINDING 20 234 0.0005205 0.008954
55 INTEGRIN BINDING 12 105 0.000548 0.009256
56 PHOSPHATIDYLINOSITOL KINASE ACTIVITY 8 51 0.00056 0.00929
57 TRANSMEMBRANE RECEPTOR PROTEIN TYROSINE KINASE ACTIVITY 9 64 0.0005898 0.009613
NumGOOverlapSizeP ValueAdj. P Value
1 CELL PROJECTION 126 1786 1.486e-12 8.676e-10
2 NEURON PART 98 1265 3.654e-12 1.067e-09
3 NEURON PROJECTION 79 942 1.251e-11 2.436e-09
4 CELL JUNCTION 88 1151 1.045e-10 1.526e-08
5 MEMBRANE REGION 86 1134 2.618e-10 3.058e-08
6 SYNAPSE 64 754 7.84e-10 7.631e-08
7 ACTIN CYTOSKELETON 42 444 3.609e-08 2.485e-06
8 SARCOLEMMA 20 125 3.878e-08 2.485e-06
9 SOMATODENDRITIC COMPARTMENT 54 650 3.611e-08 2.485e-06
10 CELL LEADING EDGE 36 350 4.256e-08 2.485e-06
11 CYTOSKELETON 119 1967 7.233e-08 3.84e-06
12 DENDRITE 41 451 1.557e-07 7.577e-06
13 PLASMA MEMBRANE REGION 67 929 1.919e-07 8.622e-06
14 CELL SURFACE 57 757 4.148e-07 1.674e-05
15 SYNAPSE PART 49 610 4.301e-07 1.674e-05
16 POSTSYNAPSE 35 378 8.244e-07 3.009e-05
17 CELL BODY 41 494 1.681e-06 5.775e-05
18 MEMBRANE MICRODOMAIN 27 288 1.171e-05 0.0003798
19 BASAL PART OF CELL 10 51 1.586e-05 0.0004875
20 PLASMA MEMBRANE PROTEIN COMPLEX 39 510 2.023e-05 0.0005907
21 BASAL PLASMA MEMBRANE 8 33 2.209e-05 0.0006142
22 T TUBULE 9 45 3.57e-05 0.0009477
23 ANCHORING JUNCTION 37 489 4.112e-05 0.001044
24 CELL CELL JUNCTION 31 383 4.943e-05 0.001155
25 SYNAPTIC MEMBRANE 24 261 4.82e-05 0.001155
26 ACTIN FILAMENT 11 70 5.315e-05 0.001194
27 CELL PROJECTION PART 59 946 8.174e-05 0.001768
28 CELL SUBSTRATE JUNCTION 31 398 0.0001006 0.002098
29 PROTEIN KINASE COMPLEX 12 90 0.0001279 0.00249
30 CYTOSKELETAL PART 81 1436 0.0001263 0.00249
31 CELL CORTEX PART 14 119 0.0001432 0.002697
32 I BAND 14 121 0.0001712 0.003029
33 NEURON SPINE 14 121 0.0001712 0.003029
34 CATION CHANNEL COMPLEX 17 167 0.0001775 0.003049
35 PRESYNAPTIC MEMBRANE 9 55 0.0001836 0.003063
36 FILOPODIUM 12 94 0.0001946 0.003072
37 PERIKARYON 13 108 0.0001946 0.003072
38 LAMELLIPODIUM 17 172 0.0002529 0.003687
39 RECEPTOR COMPLEX 26 327 0.0002589 0.003687
40 CELL CORTEX 21 238 0.0002483 0.003687
41 RUFFLE 16 156 0.00025 0.003687
42 PLASMA MEMBRANE RAFT 11 86 0.00035 0.004867
43 BASOLATERAL PLASMA MEMBRANE 19 211 0.0003733 0.00507
44 INTRINSIC COMPONENT OF PLASMA MEMBRANE 88 1649 0.0004107 0.005451
45 EXCITATORY SYNAPSE 18 197 0.0004425 0.005742
46 CELL CELL CONTACT ZONE 9 64 0.0005898 0.007488
47 AXONAL GROWTH CONE 5 20 0.0006966 0.008475
48 FILAMENTOUS ACTIN 5 20 0.0006966 0.008475
49 COATED PIT 9 67 0.0008292 0.009882
50 CORTICAL CYTOSKELETON 10 81 0.0008525 0.009957

Over-represented Pathway

NumPathwayPathviewOverlapSizeP ValueAdj. P Value
1 Focal_adhesion_hsa04510 30 199 7.362e-11 3.828e-09
2 Rap1_signaling_pathway_hsa04015 26 206 5.916e-08 1.249e-06
3 Regulation_of_actin_cytoskeleton_hsa04810 26 208 7.205e-08 1.249e-06
4 PI3K_Akt_signaling_pathway_hsa04151 35 352 1.508e-07 1.629e-06
5 Apelin_signaling_pathway_hsa04371 20 137 1.847e-07 1.629e-06
6 cGMP_PKG_signaling_pathway_hsa04022 22 163 1.88e-07 1.629e-06
7 Signaling_pathways_regulating_pluripotency_of_stem_cells_hsa04550 19 139 1.047e-06 7.776e-06
8 MAPK_signaling_pathway_hsa04010 29 295 2.195e-06 1.427e-05
9 Hippo_signaling_pathway_hsa04390 19 154 4.952e-06 2.861e-05
10 FoxO_signaling_pathway_hsa04068 17 132 8.673e-06 4.51e-05
11 cAMP_signaling_pathway_hsa04024 21 198 1.739e-05 8.222e-05
12 Ras_signaling_pathway_hsa04014 23 232 2.115e-05 9.163e-05
13 mTOR_signaling_pathway_hsa04150 17 151 5.08e-05 0.0002032
14 Autophagy_animal_hsa04140 14 128 0.0003094 0.001068
15 ErbB_signaling_pathway_hsa04012 11 85 0.0003157 0.001068
16 Adherens_junction_hsa04520 10 72 0.0003287 0.001068
17 Wnt_signaling_pathway_hsa04310 15 146 0.000379 0.001159
18 Gap_junction_hsa04540 11 88 0.0004281 0.001237
19 AMPK_signaling_pathway_hsa04152 13 121 0.0005957 0.001574
20 Hippo_signaling_pathway_multiple_species_hsa04392 6 29 0.0006053 0.001574
21 Phospholipase_D_signaling_pathway_hsa04072 14 146 0.00116 0.002873
22 Sphingolipid_signaling_pathway_hsa04071 12 118 0.001544 0.00365
23 ECM_receptor_interaction_hsa04512 9 82 0.003466 0.007615
24 Calcium_signaling_pathway_hsa04020 15 182 0.003515 0.007615
25 Phosphatidylinositol_signaling_system_hsa04070 10 99 0.003887 0.008085
26 HIF_1_signaling_pathway_hsa04066 10 100 0.004178 0.008357
27 Hedgehog_signaling_pathway_hsa04340 6 47 0.007755 0.01462
28 Jak_STAT_signaling_pathway_hsa04630 13 162 0.007872 0.01462
29 Cell_adhesion_molecules_.CAMs._hsa04514 12 145 0.008263 0.01482
30 Tight_junction_hsa04530 13 170 0.01154 0.02
31 p53_signaling_pathway_hsa04115 7 68 0.01328 0.02228
32 VEGF_signaling_pathway_hsa04370 6 59 0.02239 0.03639
33 Apoptosis_hsa04210 10 138 0.0343 0.05405
34 TGF_beta_signaling_pathway_hsa04350 7 84 0.03748 0.05635
35 Cellular_senescence_hsa04218 11 160 0.03793 0.05635
36 Oocyte_meiosis_hsa04114 8 124 0.09315 0.1346
37 TNF_signaling_pathway_hsa04668 7 108 0.1097 0.1541
38 NF_kappa_B_signaling_pathway_hsa04064 6 95 0.1446 0.1978
39 Apoptosis_multiple_species_hsa04215 2 33 0.3507 0.4676
40 Mitophagy_animal_hsa04137 3 65 0.4398 0.5624
41 Ferroptosis_hsa04216 2 40 0.4435 0.5624
42 ABC_transporters_hsa02010 2 45 0.505 0.6253
43 Notch_signaling_pathway_hsa04330 2 48 0.5398 0.6504
44 Cytokine_cytokine_receptor_interaction_hsa04060 10 270 0.5561 0.6504
45 Endocytosis_hsa04144 9 244 0.5628 0.6504
46 Phagosome_hsa04145 5 152 0.6751 0.7632
47 Neuroactive_ligand_receptor_interaction_hsa04080 8 278 0.8193 0.8717
48 Peroxisome_hsa04146 2 83 0.8214 0.8717
49 Cell_cycle_hsa04110 3 124 0.8467 0.8806
50 Lysosome_hsa04142 2 123 0.947 0.9656
51 Necroptosis_hsa04217 2 164 0.9859 0.9859

Quest ID: 2a96ceb1fa4232aa3e8d3e418a93526a