Visible node/edge number:
Node colors:
Node labels:

show label of nodes with degree >=

Node sizes:
Edge colors:
Edge widths factor:
Layout:

gravity >=

edgeLength =

GRN in network:

Notice: IE browser need to manually refresh (F5) this page after resetting the network.

This regulatory network was inferred from the input dataset. The miRNAs and mRNAs are presented as round and rectangle nodes respectively. The numerical value popped up upon mouse over the gene node is the log2 transformed fold-change of the gene expression between the two groups. All of the nodes are clickable, and the detailed information of the miRNAs/mRNAs and related cancer pathway will be displayed in another window. The edges between nodes are supported by both interactions (predicted or experimentally verified) and correlations learnt from cancer dataset. The numerical value popped up upon mouse over the edge is the correlation beat value (effect size) between the two nodes. The experimental evidences of the edges reported in previous cancer studies are highlighted by red/orange color. All of these information can be accessed by the "mouse-over" action. This network shows a full map of the miRNA-mRNA regulation of the input gene list(s), and the hub miRNAs (with the high network degree/betweenness centrality) would be the potential cancer drivers or tumor suppressors. The full result table can be accessed in the "Regulations" tab.

"miRNACancerMAP" is also a network visualization tool for users to draw their regulatory network by personal customization. Users can set the complexity of the network by limiting the number of nodes or edges. And the color of the nodes can be defined by different categories of the mRNAs and miRNAs, such as Gene-Ontology, pathway, and expression status. Users can also select to use network degree or network betweenness centrality to define the node size. And edges can be black or colored by the correlation. Purple edge means negative correlation (mostly found between miRNA and mRNA), and blue edge means positive correlation (found in PPI or miRNA-miRNA sponge effect). We can also add the protein-protein interactions (PPI) into the network. This result will show the cluster of genes regulated by some specific miRNAs. Additionally, miRNA-miRNA edges can be added by the "miRNA sponge" button, presenting some clusters of miRNAs that have the interactions via sponge effect.

miRNA-gene regulations

(Download full result)

Num microRNA           Gene miRNA log2FC miRNA pvalue Gene log2FC Gene pvalue Interaction Correlation beta Correlation P-value PMID Reported in cancer studies
1 hsa-miR-324-5p GLI1 -0.34 0.60486 1.57 8.0E-5 mir2Disease; miRNAWalker2 validate; miRTarBase -0.2 0.00636
2 hsa-let-7a-5p BMPR1B -0.1 0.96072 2.54 0 miRNAWalker2 validate -0.78 0.00135
3 hsa-let-7a-5p CAND2 -0.1 0.96072 1.47 0.00058 miRNAWalker2 validate -0.65 8.0E-5
4 hsa-let-7a-5p CDKN1A -0.1 0.96072 -0.22 0.8242 miRNAWalker2 validate; MirTarget; TargetScan -0.36 0.00039
5 hsa-let-7a-5p CFL2 -0.1 0.96072 1.04 0.16276 miRNAWalker2 validate; TargetScan -0.51 0.00074
6 hsa-let-7a-5p FKBP8 -0.1 0.96072 -0.22 0.83944 miRNAWalker2 validate -0.51 0
7 hsa-let-7a-5p GPM6B -0.1 0.96072 0.57 0.19115 miRNAWalker2 validate -0.36 0.0288
8 hsa-let-7a-5p HDAC5 -0.1 0.96072 0.07 0.93037 miRNAWalker2 validate -0.25 0.00066
9 hsa-let-7a-5p ITM2B -0.1 0.96072 0.04 0.97599 miRNAWalker2 validate -0.15 0.012
10 hsa-let-7a-5p JPH4 -0.1 0.96072 0.99 0.00114 miRNAWalker2 validate -0.34 0.01534
11 hsa-let-7a-5p MEIS1 -0.1 0.96072 0.99 0.11873 miRNAWalker2 validate -0.38 0.00563
12 hsa-let-7a-5p NEFM -0.1 0.96072 0.87 0.10675 miRNAWalker2 validate; TargetScan; miRNATAP -0.49 0.04548
13 hsa-let-7a-5p NME4 -0.1 0.96072 0.19 0.82204 miRNAWalker2 validate; MirTarget; TargetScan; miRNATAP -0.6 0
14 hsa-let-7a-5p NPTX1 -0.1 0.96072 3.32 0 miRNAWalker2 validate -0.98 0.00186
15 hsa-let-7a-5p PNRC1 -0.1 0.96072 0.33 0.75088 miRNAWalker2 validate -0.13 0.03661
16 hsa-let-7a-5p PTGS1 -0.1 0.96072 0.11 0.87519 miRNAWalker2 validate -0.39 0.00374
17 hsa-let-7a-5p SNX2 -0.1 0.96072 0.08 0.92613 miRNAWalker2 validate -0.1 0.03865
18 hsa-let-7b-3p SYT4 -0.37 0.56889 1.93 0.01491 miRNAWalker2 validate -1.61 0
19 hsa-let-7b-5p AMPH -0.1 0.95791 0.93 0.00106 miRNAWalker2 validate -0.24 0.04099
20 hsa-let-7b-5p AR -0.1 0.95791 1.5 0.00059 miRNAWalker2 validate -0.48 0.00744
21 hsa-let-7b-5p ARID3A -0.1 0.95791 0.43 0.42579 miRNAWalker2 validate -0.28 0.0142
22 hsa-let-7b-5p CCNG1 -0.1 0.95791 0.03 0.97684 miRNAWalker2 validate -0.16 0.02966
23 hsa-let-7b-5p CKB -0.1 0.95791 0.57 0.55432 miRNAWalker2 validate -0.66 0.00071
24 hsa-let-7b-5p DMD -0.1 0.95791 1.2 0.08723 miRNAWalker2 validate; MirTarget; miRNATAP -0.57 0.00107
25 hsa-let-7b-5p DPYSL5 -0.1 0.95791 2.53 0.00136 miRNAWalker2 validate -0.97 0.00115
26 hsa-let-7b-5p DZIP1 -0.1 0.95791 1.02 0.03864 miRNAWalker2 validate; miRNATAP -0.35 0.00627
27 hsa-let-7b-5p GLTSCR2 -0.1 0.95791 0.04 0.97281 miRNAWalker2 validate -0.15 0.02223
28 hsa-let-7b-5p GPM6B -0.1 0.95791 0.57 0.19115 miRNAWalker2 validate -0.35 0.02639
29 hsa-let-7b-5p HADHA -0.1 0.95791 -0.3 0.77781 miRNAWalker2 validate -0.13 0.01258
30 hsa-let-7b-5p NME4 -0.1 0.95791 0.19 0.82204 miRNAWalker2 validate; MirTarget; miRNATAP -0.43 6.0E-5
31 hsa-let-7b-5p PPP1R12C -0.1 0.95791 0.19 0.82916 miRNAWalker2 validate -0.4 0
32 hsa-let-7b-5p PRKAA2 -0.1 0.95791 1.97 0.00106 miRNAWalker2 validate; MirTarget -0.83 0.00199
33 hsa-let-7b-5p SALL2 -0.1 0.95791 1.59 0.00056 miRNAWalker2 validate -0.6 0.00051
34 hsa-let-7b-5p SLC25A4 -0.1 0.95791 -0.28 0.70885 miRNAWalker2 validate; miRNATAP -0.41 0.00074
35 hsa-let-7b-5p WLS -0.1 0.95791 0.08 0.92389 miRNAWalker2 validate -0.4 0.00021
36 hsa-let-7b-5p ZER1 -0.1 0.95791 -0.11 0.89952 miRNAWalker2 validate -0.16 0.00258
37 hsa-let-7c-5p ATP2A2 1.35 0.35898 -0.09 0.93867 miRNAWalker2 validate -0.09 0.00012
38 hsa-let-7c-5p CCNB2 1.35 0.35898 -0.49 0.45946 miRNAWalker2 validate -0.36 0
39 hsa-let-7c-5p CCNF 1.35 0.35898 -0.43 0.49658 miRNAWalker2 validate; MirTarget -0.34 0
40 hsa-let-7c-5p CCNG1 1.35 0.35898 0.03 0.97684 miRNAWalker2 validate -0.1 0.00563
41 hsa-let-7c-5p DDX18 1.35 0.35898 -0.09 0.91678 miRNAWalker2 validate -0.11 0
42 hsa-let-7c-5p FANCI 1.35 0.35898 -0.24 0.73966 miRNAWalker2 validate -0.27 0
43 hsa-let-7c-5p IVNS1ABP 1.35 0.35898 -0.5 0.6004 miRNAWalker2 validate -0.19 0
44 hsa-let-7c-5p RALGAPA2 1.35 0.35898 -0.38 0.6835 miRNAWalker2 validate -0.16 4.0E-5
45 hsa-let-7c-5p RFWD3 1.35 0.35898 -0.24 0.73958 miRNAWalker2 validate -0.13 3.0E-5
46 hsa-let-7c-5p WDR3 1.35 0.35898 -0.21 0.75716 miRNAWalker2 validate -0.16 0
47 hsa-let-7d-5p ARRDC4 -0.42 0.70488 0.25 0.73073 miRNAWalker2 validate; MirTarget; miRNATAP -0.45 0
48 hsa-let-7d-5p MPL -0.42 0.70488 0.32 0.15175 miRNAWalker2 validate -0.7 0
49 hsa-let-7d-5p THBS1 -0.42 0.70488 0.9 0.44183 miRNAWalker2 validate -0.51 0
50 hsa-let-7d-5p TLE4 -0.42 0.70488 0.03 0.96512 miRNAWalker2 validate -0.62 0
51 hsa-let-7e-5p CCNG1 0.29 0.83523 0.03 0.97684 miRNAWalker2 validate -0.3 0
52 hsa-let-7e-5p LSR 0.29 0.83523 -0.51 0.65688 miRNAWalker2 validate -0.28 0.00157
53 hsa-let-7e-5p MSMO1 0.29 0.83523 -0.26 0.74358 miRNAWalker2 validate -0.14 0.04144
54 hsa-let-7e-5p OCLN 0.29 0.83523 -0.35 0.62326 miRNAWalker2 validate -0.21 0.0426
55 hsa-let-7e-5p RPL10 0.29 0.83523 -0.09 0.94011 miRNAWalker2 validate -0.16 0.00142
56 hsa-let-7e-5p SGSM3 0.29 0.83523 -0.36 0.67457 miRNAWalker2 validate -0.23 0
57 hsa-let-7e-5p USE1 0.29 0.83523 -0.1 0.84332 miRNAWalker2 validate -0.15 0.00201
58 hsa-let-7f-5p ATL1 -0.17 0.92584 0.37 0.35698 miRNAWalker2 validate -0.27 0.00066
59 hsa-let-7f-5p CDKN1A -0.17 0.92584 -0.22 0.8242 miRNAWalker2 validate; MirTarget -0.25 0.00539
60 hsa-let-7f-5p MPL -0.17 0.92584 0.32 0.15175 miRNAWalker2 validate -0.35 0.00016
61 hsa-let-7f-5p ROR2 -0.17 0.92584 1.82 0.00433 miRNAWalker2 validate -0.73 0
62 hsa-let-7f-5p USP2 -0.17 0.92584 0.43 0.32541 miRNAWalker2 validate -0.54 0.00035
63 hsa-let-7g-5p COL1A2 -0.33 0.80464 0.68 0.6417 miRNAWalker2 validate; miRTarBase; MirTarget; miRNATAP -0.31 0.00943
64 hsa-let-7i-5p EGLN3 0.32 0.79276 -0.09 0.89325 miRNAWalker2 validate -0.36 0.00083
65 hsa-miR-100-5p ALG3 1.42 0.39229 -0.21 0.8077 miRNAWalker2 validate -0.2 0
66 hsa-miR-100-5p ANAPC1 1.42 0.39229 -0.2 0.74891 miRNAWalker2 validate -0.17 0
67 hsa-miR-100-5p ATP2A2 1.42 0.39229 -0.09 0.93867 miRNAWalker2 validate -0.13 0
68 hsa-miR-100-5p ATP5A1 1.42 0.39229 -0.39 0.73695 miRNAWalker2 validate -0.15 0
69 hsa-miR-100-5p CBX3 1.42 0.39229 -0.14 0.88752 miRNAWalker2 validate -0.2 0
70 hsa-miR-100-5p CCNG1 1.42 0.39229 0.03 0.97684 miRNAWalker2 validate -0.11 0.00585
71 hsa-miR-100-5p DCBLD1 1.42 0.39229 -0.03 0.95657 miRNAWalker2 validate -0.14 9.0E-5
72 hsa-miR-100-5p DDAH1 1.42 0.39229 -0.32 0.74116 miRNAWalker2 validate -0.36 0
73 hsa-miR-100-5p DDX21 1.42 0.39229 -0.08 0.93625 miRNAWalker2 validate -0.23 0
74 hsa-miR-100-5p DNMT1 1.42 0.39229 -0.22 0.79859 miRNAWalker2 validate -0.19 0
75 hsa-miR-100-5p FOXN2 1.42 0.39229 0.05 0.93794 miRNAWalker2 validate -0.12 3.0E-5
76 hsa-miR-100-5p HIST1H4C 1.42 0.39229 -0.11 0.61941 miRNAWalker2 validate -0.17 0.00061
77 hsa-miR-100-5p ID1 1.42 0.39229 -0.83 0.37533 miRNAWalker2 validate -0.33 0
78 hsa-miR-100-5p KPNA2 1.42 0.39229 -0.44 0.63267 miRNAWalker2 validate -0.34 0
79 hsa-miR-100-5p NIP7 1.42 0.39229 -0.16 0.81356 miRNAWalker2 validate -0.14 0
80 hsa-miR-100-5p NOP2 1.42 0.39229 -0.18 0.81491 miRNAWalker2 validate -0.23 0
81 hsa-miR-100-5p PLK1 1.42 0.39229 -0.51 0.51292 miRNAWalker2 validate; miRTarBase -0.45 0 21636267; 21636267; 21636267; 21636267; 21636267; 21636267; 23842624; 23842624; 23842624; 23151088; 23151088; 23151088; 23151088; 23151088; 22246341; 22246341; 22120675; 22120675; 22120675 Reduced miR-100 expression in cervical cancer and precursors and its carcinogenic effect through targeting PLK1 protein;Through modulating miR-100 expression using miR-100 inhibitor or mimic in vitro cell growth cycle and apoptosis were tested separately by MTT or flow cytometry and meanwhile Polo-like kinase1 PLK1 mRNA and protein expressions were detected by qRT-PCR and immunoblotting;The expression of PLK1 in 125 cervical tissues was also examined by immunohistochemical staining and the correlation between miR-100 and PLK1 expression in the same tissues was analysed;The modulation of miR-100 expression remarkably influenced cell proliferation cycle and apoptosis as well as the level of PLK1 protein but not mRNA in vitro experiments;PLK1 expression was negatively correlated with miR-100 expression in CIN3 and cervical cancer tissues;The reduced miR-100 expression participates in the development of cervical cancer at least partly through loss of inhibition to target gene PLK1 which probably occurs in a relative late phase of carcinogenesis;In addition we found that upregulation of miR-100 could inhibit growth and increase apoptosis of HCC cells by downregulating polo-like kinase 1 plk1;In HCC tissues miR-100 expression was inversely correlated with the expression of plk1 protein r = -0.418; P = 0.029;Therefore downregulation of miR-100 was correlated with progressive pathological feature and poor prognosis in HCC patients and miR-100 could function as a tumor suppressor by targeting plk1;MicroRNA-100 is a potential molecular marker of non-small cell lung cancer and functions as a tumor suppressor by targeting polo-like kinase 1;Finally the effects of miR-100 expression on growth apoptosis and cell cycle of NSCLC cells by posttranscriptionally regulating PLK1 expression were determined;Meanwhile miR-100 mimics could significantly inhibit PLK1 mRNA and protein expression and reduce the luciferase activity of a PLK1 3' untranslated region-based reporter construct in A549 cells;Furthermore small interfering RNA siRNA-mediated PLK1 downregulation could mimic the effects of miR-100 mimics while PLK1 overexpression could partially rescue the phenotypical changes of NSCLC cells induced by miR-100 mimics;Our findings indicate that low miR-100 may be a poor prognostic factor for NSCLC patients and functions as a tumor suppressor by posttranscriptionally regulating PLK1 expression;Additionally miR-100 could affect the growth of EOC cells by post-transcriptionally regulating polo-like kinase 1 PLK1 expression;Together these results suggest that low miR-100 expression may be an independent poor prognostic factor and miR-100 can function as a tumor suppressor by targeting PLK1 in human EOCs;Knock-down of Plk1 which was a direct target of miR-100 yielded similar effects as that of ectopic miR-100 expression;The inverse correlation between miR-100 and Plk1 expression was also detected in nude mice SPC-A1/DTX tumor xenografts and clinical lung adenocarcinoma tissues and was proved to be related with the in vivo response to docetaxel;Thus our results suggested that down-regulation of miR-100 could lead to Plk1 over-expression and eventually to docetaxel chemoresistance of human lung adenocarcinoma
82 hsa-miR-100-5p PRRC2C 1.42 0.39229 -0.05 0.96788 miRNAWalker2 validate -0.12 1.0E-5
83 hsa-miR-100-5p RHPN2 1.42 0.39229 -0.49 0.58485 miRNAWalker2 validate -0.44 0
84 hsa-miR-100-5p RPL7L1 1.42 0.39229 -0.28 0.69158 miRNAWalker2 validate -0.15 0
85 hsa-miR-100-5p RRM2 1.42 0.39229 -0.4 0.63872 miRNAWalker2 validate -0.53 0
86 hsa-miR-100-5p SF3B3 1.42 0.39229 -0.32 0.75994 miRNAWalker2 validate -0.12 3.0E-5
87 hsa-miR-100-5p WDR4 1.42 0.39229 -0.21 0.66337 miRNAWalker2 validate -0.16 1.0E-5
88 hsa-miR-101-3p CDC7 0.19 0.91798 -0.33 0.4365 miRNAWalker2 validate -0.26 0.01503
89 hsa-miR-101-3p E2F3 0.19 0.91798 -0.01 0.99276 miRNAWalker2 validate -0.2 0.00606
90 hsa-miR-101-3p KIF2C 0.19 0.91798 -0.34 0.59058 miRNAWalker2 validate -0.34 0.00973
91 hsa-miR-101-3p KLHL23 0.19 0.91798 0.26 0.69716 miRNAWalker2 validate -0.34 0.00102
92 hsa-miR-101-3p MMS22L 0.19 0.91798 -0.14 0.7841 miRNAWalker2 validate -0.24 0.00704
93 hsa-miR-101-3p MSH2 0.19 0.91798 -0.27 0.67752 miRNAWalker2 validate -0.17 0.03146
94 hsa-miR-101-3p NOP2 0.19 0.91798 -0.18 0.81491 miRNAWalker2 validate -0.21 0.00769
95 hsa-miR-101-3p RPL7L1 0.19 0.91798 -0.28 0.69158 miRNAWalker2 validate -0.26 6.0E-5
96 hsa-miR-101-3p SUZ12 0.19 0.91798 -0.17 0.83091 miRNAWalker2 validate -0.19 0.00128
97 hsa-miR-101-3p VEGFA 0.19 0.91798 -0.52 0.59274 miRNAWalker2 validate -0.23 0.02392
98 hsa-miR-101-5p PRKDC 0.53 0.20475 -0.25 0.81734 miRNAWalker2 validate; miRTarBase -0.26 0
99 hsa-miR-103a-3p BCL2 -0.31 0.872 0.37 0.50114 miRNAWalker2 validate -0.34 1.0E-5
100 hsa-miR-103a-3p CAV1 -0.31 0.872 0.78 0.40856 miRNAWalker2 validate; miRTarBase -0.59 0
101 hsa-miR-103a-3p CITED2 -0.31 0.872 0.51 0.53494 miRNAWalker2 validate -0.57 0
102 hsa-miR-103a-3p CPEB2 -0.31 0.872 -0.09 0.88872 miRNAWalker2 validate -0.13 0.01594
103 hsa-miR-103a-3p DNAJB4 -0.31 0.872 0.62 0.27225 miRNAWalker2 validate -0.26 4.0E-5
104 hsa-miR-103a-3p FGF2 -0.31 0.872 0.83 0.10492 miRNAWalker2 validate; MirTarget; miRNATAP -0.52 0
105 hsa-miR-103a-3p GABARAPL1 -0.31 0.872 0.88 0.22594 miRNAWalker2 validate -0.47 0
106 hsa-miR-103a-3p GLRX -0.31 0.872 0.13 0.85115 miRNAWalker2 validate -0.2 0.00504
107 hsa-miR-103a-3p IGSF3 -0.31 0.872 -0.08 0.90774 miRNAWalker2 validate; MirTarget; miRNATAP -0.26 0.00059
108 hsa-miR-103a-3p ITM2C -0.31 0.872 0.41 0.67235 miRNAWalker2 validate -0.42 0
109 hsa-miR-103a-3p JAKMIP2 -0.31 0.872 1.32 5.0E-5 miRNAWalker2 validate; MirTarget; miRNATAP -0.77 0
110 hsa-miR-103a-3p KIF5A -0.31 0.872 1.15 0.00462 miRNAWalker2 validate; MirTarget; miRNATAP -0.64 0
111 hsa-miR-103a-3p KLF4 -0.31 0.872 -0.62 0.5144 miRNAWalker2 validate; miRTarBase -0.26 0.0044
112 hsa-miR-103a-3p NDEL1 -0.31 0.872 -0.04 0.95525 miRNAWalker2 validate; MirTarget; miRNATAP -0.16 0
113 hsa-miR-103a-3p PDK4 -0.31 0.872 1.45 0.10369 miRNAWalker2 validate; MirTarget -0.92 0
114 hsa-miR-103a-3p PPP1R12C -0.31 0.872 0.19 0.82916 miRNAWalker2 validate -0.34 0
115 hsa-miR-103a-3p RECK -0.31 0.872 1.23 0.01624 miRNAWalker2 validate -0.57 0
116 hsa-miR-103a-3p RIMS3 -0.31 0.872 0.51 0.21482 miRNAWalker2 validate; MirTarget; miRNATAP -0.71 0
117 hsa-miR-103a-3p RNF217 -0.31 0.872 1.11 0.00089 miRNAWalker2 validate -0.63 0
118 hsa-miR-103a-3p RUNX1T1 -0.31 0.872 1.89 0.00014 miRNAWalker2 validate; miRNATAP -0.64 0
119 hsa-miR-103a-3p SIRT4 -0.31 0.872 0.18 0.42779 miRNAWalker2 validate -0.36 0
120 hsa-miR-103a-3p TLE4 -0.31 0.872 0.03 0.96512 miRNAWalker2 validate -0.34 0
121 hsa-miR-103a-3p TMEM100 -0.31 0.872 1.66 0.00094 miRNAWalker2 validate -1.28 0
122 hsa-miR-106a-5p CDKN1A -0.19 0.71237 -0.22 0.8242 miRNAWalker2 validate; miRTarBase; MirTarget; miRNATAP -0.17 0.00069
123 hsa-miR-106a-5p CYP19A1 -0.19 0.71237 0.91 0.08913 miRNAWalker2 validate -0.28 0.00536
124 hsa-miR-106b-3p NFE2L2 -0.48 0.66253 -0.1 0.92003 miRNAWalker2 validate -0.18 0
125 hsa-miR-106b-3p SALL2 -0.48 0.66253 1.59 0.00056 miRNAWalker2 validate -0.76 0
126 hsa-miR-106b-3p UQCR11 -0.48 0.66253 -0.1 0.91385 miRNAWalker2 validate -0.1 0.01446
127 hsa-miR-106b-5p CDK5R2 -0.53 0.63002 2.3 8.0E-5 miRNAWalker2 validate -0.43 0.00922
128 hsa-miR-106b-5p CROT -0.53 0.63002 0.33 0.536 miRNAWalker2 validate; MirTarget -0.34 0
129 hsa-miR-106b-5p EEF1A1 -0.53 0.63002 -0.09 0.94283 miRNAWalker2 validate -0.08 0.03819
130 hsa-miR-106b-5p EIF3F -0.53 0.63002 0 0.99751 miRNAWalker2 validate -0.07 0.01743
131 hsa-miR-106b-5p FNBP1 -0.53 0.63002 1.36 0.1194 miRNAWalker2 validate -0.76 0
132 hsa-miR-106b-5p GPM6A -0.53 0.63002 2.53 3.0E-5 miRNAWalker2 validate -1.79 0
133 hsa-miR-106b-5p KANK2 -0.53 0.63002 0.68 0.47404 miRNAWalker2 validate; mirMAP -0.81 0
134 hsa-miR-106b-5p KAT2B -0.53 0.63002 0.42 0.54575 miRNAWalker2 validate; miRTarBase; MirTarget -0.55 0
135 hsa-miR-106b-5p KIF5C -0.53 0.63002 0.69 0.01966 miRNAWalker2 validate -0.47 0
136 hsa-miR-106b-5p LIN7B -0.53 0.63002 -0.02 0.93798 miRNAWalker2 validate -0.23 0
137 hsa-miR-106b-5p MXI1 -0.53 0.63002 -0.03 0.97244 miRNAWalker2 validate -0.38 0
138 hsa-miR-106b-5p MYL6 -0.53 0.63002 0.23 0.85536 miRNAWalker2 validate -0.35 0
139 hsa-miR-106b-5p NEFH -0.53 0.63002 1.17 9.0E-5 miRNAWalker2 validate -0.51 0
140 hsa-miR-106b-5p RORA -0.53 0.63002 0.64 0.26502 miRNAWalker2 validate; MirTarget; miRNATAP -0.54 0
141 hsa-miR-106b-5p RUNX1T1 -0.53 0.63002 1.89 0.00014 miRNAWalker2 validate -0.95 0
142 hsa-miR-106b-5p SMAD9 -0.53 0.63002 1.2 0.03703 miRNAWalker2 validate; mirMAP -0.91 0
143 hsa-miR-106b-5p STX12 -0.53 0.63002 -0.07 0.93021 miRNAWalker2 validate -0.2 0
144 hsa-miR-106b-5p SYT4 -0.53 0.63002 1.93 0.01491 miRNAWalker2 validate -1.35 0
145 hsa-miR-106b-5p TCEAL1 -0.53 0.63002 0.05 0.93323 miRNAWalker2 validate; miRTarBase -0.38 0
146 hsa-miR-107 ADD2 -0.37 0.6651 1.7 1.0E-5 miRNAWalker2 validate; miRNATAP -0.81 0
147 hsa-miR-107 CHRM1 -0.37 0.6651 -1.22 0.04287 miRNAWalker2 validate; PITA; miRNATAP -0.59 0.01493
148 hsa-miR-107 PHGDH -0.37 0.6651 0.36 0.62551 miRNAWalker2 validate; miRanda -0.47 0.00191 23385731 TaqMan quantitative RT-PCR analyses indicated that four of them miR-103 miR-107 miR-194 and miR-210 were significantly upregulated in sera of both early and advanced-stage DGC-bearing mice compared with in corresponding controls
149 hsa-miR-10a-5p AJUBA -0.02 0.99071 0.08 0.90125 miRNAWalker2 validate -0.23 0.00591
150 hsa-miR-10a-5p C5 -0.02 0.99071 0.46 0.23262 miRNAWalker2 validate -0.2 0.01155

Over-represented Gene Ontology Biological Process

NumGOOverlapSizeP ValueAdj. P Value
1 NEUROGENESIS 420 1402 1.511e-27 7.029e-24
2 RESPONSE TO ENDOGENOUS STIMULUS 428 1450 1.346e-26 3.131e-23
3 REGULATION OF MULTICELLULAR ORGANISMAL DEVELOPMENT 467 1672 2.285e-23 3.544e-20
4 CELL DEVELOPMENT 408 1426 1.718e-22 1.999e-19
5 RESPONSE TO ORGANIC CYCLIC COMPOUND 287 917 5.98e-22 5.565e-19
6 RESPONSE TO OXYGEN CONTAINING COMPOUND 389 1381 3.789e-20 2.519e-17
7 TISSUE DEVELOPMENT 420 1518 3.519e-20 2.519e-17
8 POSITIVE REGULATION OF DEVELOPMENTAL PROCESS 330 1142 5.74e-19 3.339e-16
9 BEHAVIOR 178 516 1.324e-18 6.845e-16
10 REGULATION OF ION TRANSPORT 197 592 1.682e-18 7.828e-16
11 POSITIVE REGULATION OF MULTICELLULAR ORGANISMAL PROCESS 385 1395 2.541e-18 1.075e-15
12 CENTRAL NERVOUS SYSTEM DEVELOPMENT 264 872 4.014e-18 1.557e-15
13 NEURON DIFFERENTIATION 263 874 1.108e-17 3.967e-15
14 REGULATION OF NERVOUS SYSTEM DEVELOPMENT 233 750 1.491e-17 4.955e-15
15 NEURON PROJECTION MORPHOGENESIS 145 402 2.82e-17 8.201e-15
16 CELLULAR RESPONSE TO ENDOGENOUS STIMULUS 293 1008 2.679e-17 8.201e-15
17 REGULATION OF MEMBRANE POTENTIAL 129 343 3.546e-17 9.707e-15
18 REGULATION OF CELL DIFFERENTIATION 399 1492 1.63e-16 4.213e-14
19 REGULATION OF SYSTEM PROCESS 170 507 1.772e-16 4.34e-14
20 SINGLE ORGANISM BEHAVIOR 138 384 2.359e-16 5.488e-14
21 CELL CELL SIGNALING 233 767 2.699e-16 5.827e-14
22 REGULATION OF TRANSPORT 466 1804 2.755e-16 5.827e-14
23 EXTRACELLULAR STRUCTURE ORGANIZATION 116 304 4.063e-16 8.22e-14
24 BIOLOGICAL ADHESION 294 1032 4.492e-16 8.708e-14
25 MODULATION OF SYNAPTIC TRANSMISSION 115 301 4.891e-16 9.103e-14
26 CELL MORPHOGENESIS INVOLVED IN DIFFERENTIATION 170 513 6.17e-16 1.104e-13
27 REGULATION OF BLOOD CIRCULATION 113 295 7.079e-16 1.22e-13
28 NEGATIVE REGULATION OF MULTICELLULAR ORGANISMAL PROCESS 281 983 1.318e-15 2.19e-13
29 RESPONSE TO HORMONE 260 893 1.518e-15 2.435e-13
30 REGULATION OF NEURON DIFFERENTIATION 179 554 1.611e-15 2.499e-13
31 REGULATION OF CELL PROLIFERATION 394 1496 3.406e-15 5.113e-13
32 NEGATIVE REGULATION OF DEVELOPMENTAL PROCESS 237 801 4.112e-15 5.979e-13
33 NEURON PROJECTION DEVELOPMENT 175 545 6.411e-15 9.04e-13
34 RESPONSE TO LIPID 256 888 9.065e-15 1.241e-12
35 SYNAPSE ORGANIZATION 67 145 1.709e-14 2.272e-12
36 RESPONSE TO NITROGEN COMPOUND 248 859 2.035e-14 2.63e-12
37 REGULATION OF HEART CONTRACTION 89 221 2.78e-14 3.36e-12
38 CARDIOVASCULAR SYSTEM DEVELOPMENT 231 788 2.816e-14 3.36e-12
39 CIRCULATORY SYSTEM DEVELOPMENT 231 788 2.816e-14 3.36e-12
40 MOVEMENT OF CELL OR SUBCELLULAR COMPONENT 341 1275 3.296e-14 3.834e-12
41 RESPONSE TO ABIOTIC STIMULUS 284 1024 5.54e-14 6.287e-12
42 MUSCLE STRUCTURE DEVELOPMENT 144 432 6.338e-14 7.022e-12
43 HEAD DEVELOPMENT 211 709 7.431e-14 8.042e-12
44 CELL MORPHOGENESIS INVOLVED IN NEURON DIFFERENTIATION 127 368 1.163e-13 1.23e-11
45 NEURON DEVELOPMENT 205 687 1.278e-13 1.321e-11
46 CELLULAR RESPONSE TO ORGANIC SUBSTANCE 462 1848 1.351e-13 1.366e-11
47 SYNAPTIC SIGNALING 141 424 1.426e-13 1.411e-11
48 ION TRANSPORT 335 1262 1.664e-13 1.613e-11
49 REGULATION OF CELLULAR COMPONENT MOVEMENT 224 771 1.952e-13 1.841e-11
50 REGULATION OF CELL DEVELOPMENT 239 836 1.978e-13 1.841e-11
51 REGULATION OF TRANSMEMBRANE TRANSPORT 140 426 4.817e-13 4.395e-11
52 CHEMICAL HOMEOSTASIS 246 874 5.462e-13 4.888e-11
53 UROGENITAL SYSTEM DEVELOPMENT 107 299 7.445e-13 6.536e-11
54 LOCOMOTION 299 1114 9.152e-13 7.886e-11
55 MUSCLE SYSTEM PROCESS 102 282 1.205e-12 1.02e-10
56 MULTICELLULAR ORGANISMAL SIGNALING 57 123 1.303e-12 1.083e-10
57 REGULATION OF METAL ION TRANSPORT 113 325 1.509e-12 1.232e-10
58 REGULATION OF NEURON PROJECTION DEVELOPMENT 134 408 1.607e-12 1.289e-10
59 CELLULAR COMPONENT MORPHOGENESIS 249 900 2.886e-12 2.276e-10
60 CELLULAR RESPONSE TO OXYGEN CONTAINING COMPOUND 226 799 2.957e-12 2.293e-10
61 POSITIVE REGULATION OF NEURON DIFFERENTIATION 107 306 3.942e-12 3.007e-10
62 RESPONSE TO ALCOHOL 121 362 5.216e-12 3.914e-10
63 DIVALENT INORGANIC CATION HOMEOSTASIS 116 343 6.089e-12 4.497e-10
64 POSITIVE REGULATION OF CELL DIFFERENTIATION 230 823 6.977e-12 5.073e-10
65 POSITIVE REGULATION OF NERVOUS SYSTEM DEVELOPMENT 139 437 8.715e-12 6.238e-10
66 RESPONSE TO DRUG 137 431 1.298e-11 9.151e-10
67 REGULATION OF SYNAPSE STRUCTURE OR ACTIVITY 86 232 1.571e-11 1.091e-09
68 CELLULAR CHEMICAL HOMEOSTASIS 170 570 1.727e-11 1.182e-09
69 BLOOD VESSEL MORPHOGENESIS 120 364 1.777e-11 1.199e-09
70 MUSCLE CONTRACTION 86 233 2.043e-11 1.358e-09
71 EPITHELIUM DEVELOPMENT 255 945 2.682e-11 1.733e-09
72 RESPONSE TO STEROID HORMONE 152 497 2.662e-11 1.733e-09
73 MUSCLE ORGAN DEVELOPMENT 97 277 3.598e-11 2.293e-09
74 NEGATIVE REGULATION OF CELL DIFFERENTIATION 178 609 3.652e-11 2.296e-09
75 POSITIVE REGULATION OF ION TRANSPORT 86 236 4.434e-11 2.679e-09
76 RESPONSE TO GROWTH FACTOR 146 475 4.406e-11 2.679e-09
77 ION HOMEOSTASIS 170 576 4.355e-11 2.679e-09
78 ION TRANSMEMBRANE TRANSPORT 226 822 5.836e-11 3.481e-09
79 CELLULAR RESPONSE TO ORGANIC CYCLIC COMPOUND 143 465 6.702e-11 3.947e-09
80 REGULATION OF ANATOMICAL STRUCTURE MORPHOGENESIS 270 1021 6.888e-11 4.006e-09
81 CARDIAC CONDUCTION 41 82 9.398e-11 5.399e-09
82 ANATOMICAL STRUCTURE FORMATION INVOLVED IN MORPHOGENESIS 255 957 1.067e-10 6.056e-09
83 NEGATIVE REGULATION OF CELL PROLIFERATION 184 643 1.176e-10 6.593e-09
84 VASCULATURE DEVELOPMENT 143 469 1.31e-10 7.257e-09
85 CELL PROJECTION ORGANIZATION 242 902 1.611e-10 8.818e-09
86 ORGAN MORPHOGENESIS 228 841 1.989e-10 1.076e-08
87 ANGIOGENESIS 99 293 2.25e-10 1.203e-08
88 COGNITION 88 251 2.687e-10 1.421e-08
89 GLAND DEVELOPMENT 124 395 2.952e-10 1.543e-08
90 EMBRYO DEVELOPMENT 239 894 3.027e-10 1.565e-08
91 ACTION POTENTIAL 44 94 3.081e-10 1.575e-08
92 TAXIS 140 464 4.514e-10 2.283e-08
93 GROWTH 127 410 4.686e-10 2.345e-08
94 REGULATION OF HORMONE LEVELS 143 478 5.607e-10 2.776e-08
95 CELL PART MORPHOGENESIS 179 633 5.879e-10 2.879e-08
96 RESPONSE TO INORGANIC SUBSTANCE 143 479 6.56e-10 3.18e-08
97 MULTICELLULAR ORGANISM METABOLIC PROCESS 43 93 7.923e-10 3.801e-08
98 CELL PROLIFERATION 187 672 9.865e-10 4.684e-08
99 CIRCULATORY SYSTEM PROCESS 115 366 1.222e-09 5.744e-08
100 REGULATION OF CELLULAR LOCALIZATION 319 1277 1.361e-09 6.332e-08
101 SKELETAL SYSTEM DEVELOPMENT 136 455 1.574e-09 7.253e-08
102 NEGATIVE REGULATION OF LOCOMOTION 89 263 1.652e-09 7.535e-08
103 POSITIVE REGULATION OF NEURON PROJECTION DEVELOPMENT 81 232 1.704e-09 7.697e-08
104 RESPONSE TO OXYGEN LEVELS 101 311 1.745e-09 7.807e-08
105 NEGATIVE REGULATION OF RESPONSE TO STIMULUS 336 1360 1.796e-09 7.958e-08
106 NEGATIVE REGULATION OF CELL COMMUNICATION 300 1192 1.928e-09 8.462e-08
107 REGULATION OF CELL DEATH 359 1472 2.356e-09 1.024e-07
108 TUBE DEVELOPMENT 158 552 2.402e-09 1.035e-07
109 POSITIVE REGULATION OF TRANSPORT 244 936 2.491e-09 1.063e-07
110 REGULATION OF DEVELOPMENTAL GROWTH 95 289 2.621e-09 1.109e-07
111 TRANSMEMBRANE TRANSPORT 279 1098 2.72e-09 1.14e-07
112 REGULATION OF CELL PROJECTION ORGANIZATION 159 558 3.024e-09 1.256e-07
113 RESPONSE TO EXTERNAL STIMULUS 431 1821 3.232e-09 1.331e-07
114 CELL MOTILITY 221 835 3.675e-09 1.487e-07
115 LOCALIZATION OF CELL 221 835 3.675e-09 1.487e-07
116 CELLULAR RESPONSE TO LIPID 135 457 4.129e-09 1.656e-07
117 MESENCHYME DEVELOPMENT 69 190 4.204e-09 1.672e-07
118 HOMEOSTATIC PROCESS 329 1337 4.267e-09 1.683e-07
119 REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 422 1784 5.215e-09 2.039e-07
120 REGULATION OF GROWTH 175 633 5.779e-09 2.222e-07
121 POSITIVE REGULATION OF CELL DEVELOPMENT 138 472 5.748e-09 2.222e-07
122 CATION TRANSPORT 211 796 7.32e-09 2.792e-07
123 MULTICELLULAR ORGANISMAL MACROMOLECULE METABOLIC PROCESS 37 79 7.654e-09 2.895e-07
124 CELLULAR RESPONSE TO HORMONE STIMULUS 156 552 7.883e-09 2.958e-07
125 RESPONSE TO KETONE 66 182 9.67e-09 3.6e-07
126 REGULATION OF HOMEOSTATIC PROCESS 131 447 1.191e-08 4.399e-07
127 REGULATION OF VASCULATURE DEVELOPMENT 79 233 1.211e-08 4.435e-07
128 METAL ION TRANSPORT 162 582 1.285e-08 4.672e-07
129 RESPONSE TO MECHANICAL STIMULUS 73 210 1.313e-08 4.736e-07
130 REGENERATION 60 161 1.402e-08 5.017e-07
131 SENSORY ORGAN DEVELOPMENT 141 493 1.832e-08 6.508e-07
132 REGULATION OF ANATOMICAL STRUCTURE SIZE 136 472 1.994e-08 7.029e-07
133 RESPONSE TO METAL ION 103 333 2.192e-08 7.561e-07
134 ORGANIC ACID METABOLIC PROCESS 243 953 2.194e-08 7.561e-07
135 DEVELOPMENTAL GROWTH 103 333 2.192e-08 7.561e-07
136 NEURON PROJECTION GUIDANCE 71 205 2.451e-08 8.386e-07
137 REGULATION OF CALCIUM ION TRANSPORT 72 209 2.518e-08 8.554e-07
138 REGULATION OF SECRETION 187 699 2.577e-08 8.69e-07
139 REGULATION OF PHOSPHORUS METABOLIC PROCESS 383 1618 2.682e-08 8.978e-07
140 GLIOGENESIS 63 175 2.855e-08 9.488e-07
141 POSITIVE REGULATION OF CALCIUM ION TRANSPORT 44 106 2.993e-08 9.878e-07
142 POSITIVE REGULATION OF BIOSYNTHETIC PROCESS 421 1805 3.305e-08 1.083e-06
143 REGULATION OF HORMONE SECRETION 85 262 3.472e-08 1.13e-06
144 POSITIVE REGULATION OF SYNAPTIC TRANSMISSION 45 110 3.552e-08 1.148e-06
145 NEGATIVE REGULATION OF CELL DEVELOPMENT 95 303 3.694e-08 1.185e-06
146 REGULATION OF POTASSIUM ION TRANSPORT 37 83 3.95e-08 1.259e-06
147 CELLULAR HOMEOSTASIS 181 676 4.049e-08 1.282e-06
148 MUSCLE TISSUE DEVELOPMENT 88 275 4.103e-08 1.29e-06
149 OSSIFICATION 82 251 4.266e-08 1.332e-06
150 CELLULAR RESPONSE TO OXYGEN LEVELS 54 143 4.334e-08 1.344e-06
151 REGULATION OF CATION TRANSMEMBRANE TRANSPORT 71 208 4.787e-08 1.475e-06
152 HEART DEVELOPMENT 133 466 5.286e-08 1.618e-06
153 REGULATION OF ION HOMEOSTASIS 69 201 5.713e-08 1.738e-06
154 STEM CELL DIFFERENTIATION 66 190 6.602e-08 1.995e-06
155 POSITIVE REGULATION OF GENE EXPRESSION 404 1733 6.904e-08 2.072e-06
156 REGULATION OF HEART RATE BY CARDIAC CONDUCTION 19 30 7.363e-08 2.196e-06
157 POSITIVE REGULATION OF CELL COMMUNICATION 362 1532 8.202e-08 2.431e-06
158 REGULATION OF MUSCLE SYSTEM PROCESS 67 195 8.502e-08 2.504e-06
159 CELLULAR RESPONSE TO NITROGEN COMPOUND 141 505 9.161e-08 2.681e-06
160 TISSUE MORPHOGENESIS 147 533 1.12e-07 3.258e-06
161 REGULATION OF EPITHELIAL CELL PROLIFERATION 89 285 1.203e-07 3.477e-06
162 CARTILAGE DEVELOPMENT 54 147 1.264e-07 3.632e-06
163 POSITIVE REGULATION OF BLOOD CIRCULATION 39 93 1.294e-07 3.67e-06
164 INORGANIC ION TRANSMEMBRANE TRANSPORT 158 583 1.29e-07 3.67e-06
165 RESPONSE TO ACID CHEMICAL 97 319 1.384e-07 3.902e-06
166 REGULATION OF CELL GROWTH 114 391 1.399e-07 3.921e-06
167 REGULATION OF NEUROTRANSMITTER LEVELS 65 190 1.58e-07 4.381e-06
168 VASCULAR PROCESS IN CIRCULATORY SYSTEM 58 163 1.582e-07 4.381e-06
169 RESPONSE TO BMP 39 94 1.819e-07 4.979e-06
170 CELLULAR RESPONSE TO BMP STIMULUS 39 94 1.819e-07 4.979e-06
171 EAR DEVELOPMENT 66 195 2.002e-07 5.447e-06
172 REGULATION OF CYTOSOLIC CALCIUM ION CONCENTRATION 68 203 2.055e-07 5.559e-06
173 MESENCHYMAL CELL DIFFERENTIATION 50 134 2.084e-07 5.605e-06
174 CARDIAC MUSCLE CELL ACTION POTENTIAL 21 37 2.225e-07 5.949e-06
175 REGULATION OF CHEMOTAXIS 62 180 2.297e-07 6.107e-06
176 POSITIVE REGULATION OF MOLECULAR FUNCTION 412 1791 2.449e-07 6.474e-06
177 FOREBRAIN DEVELOPMENT 105 357 2.698e-07 7.093e-06
178 SINGLE ORGANISM CATABOLIC PROCESS 238 957 2.736e-07 7.151e-06
179 POTASSIUM ION TRANSPORT 55 154 2.849e-07 7.407e-06
180 RESPONSE TO ORGANOPHOSPHORUS 51 139 2.918e-07 7.544e-06
181 NEGATIVE REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 191 740 2.968e-07 7.623e-06
182 RESPONSE TO PURINE CONTAINING COMPOUND 56 158 2.982e-07 7.623e-06
183 POSITIVE REGULATION OF CELL PROJECTION ORGANIZATION 92 303 3.094e-07 7.867e-06
184 REGULATION OF MUSCLE CONTRACTION 53 147 3.292e-07 8.326e-06
185 CONNECTIVE TISSUE DEVELOPMENT 65 194 3.74e-07 9.406e-06
186 REGULATION OF SYNAPTIC PLASTICITY 51 140 3.774e-07 9.441e-06
187 NEGATIVE REGULATION OF CELL DEATH 219 872 3.815e-07 9.493e-06
188 SYNAPSE ASSEMBLY 31 69 3.955e-07 9.789e-06
189 EMBRYONIC MORPHOGENESIS 146 539 3.976e-07 9.79e-06
190 REGULATION OF HEART RATE 36 86 4.1e-07 1.004e-05
191 CELL CYCLE PROCESS 263 1081 4.635e-07 1.129e-05
192 POSITIVE REGULATION OF CELL PROLIFERATION 206 814 4.759e-07 1.153e-05
193 ORGAN REGENERATION 35 83 4.784e-07 1.153e-05
194 POSITIVE REGULATION OF PHOSPHATE METABOLIC PROCESS 253 1036 5.611e-07 1.339e-05
195 POSITIVE REGULATION OF PHOSPHORUS METABOLIC PROCESS 253 1036 5.611e-07 1.339e-05
196 DEVELOPMENTAL PROCESS INVOLVED IN REPRODUCTION 159 602 6.687e-07 1.588e-05
197 POSITIVE REGULATION OF TRANSMEMBRANE TRANSPORT 48 131 6.741e-07 1.592e-05
198 EPITHELIAL CELL DIFFERENTIATION 135 495 7.194e-07 1.691e-05
199 MEMBRANE DEPOLARIZATION DURING ACTION POTENTIAL 21 39 7.349e-07 1.718e-05
200 SMOOTH MUSCLE CONTRACTION 23 45 7.48e-07 1.74e-05
201 RESPONSE TO OXIDATIVE STRESS 102 352 8.548e-07 1.979e-05
202 REGULATION OF CELL MORPHOGENESIS INVOLVED IN DIFFERENTIATION 98 337 1.169e-06 2.692e-05
203 REGULATION OF AXONOGENESIS 57 168 1.206e-06 2.764e-05
204 POSITIVE REGULATION OF LOCOMOTION 117 420 1.261e-06 2.875e-05
205 RESPONSE TO CAMP 40 104 1.354e-06 3.073e-05
206 CELL CYCLE 309 1316 1.416e-06 3.198e-05
207 REPRODUCTIVE SYSTEM DEVELOPMENT 114 408 1.464e-06 3.291e-05
208 REGULATION OF PEPTIDE SECRETION 67 209 1.508e-06 3.374e-05
209 REGULATION OF CELL CYCLE 232 949 1.539e-06 3.426e-05
210 REGULATION OF EXTENT OF CELL GROWTH 39 101 1.627e-06 3.604e-05
211 CARDIAC MUSCLE CELL CONTRACTION 17 29 1.735e-06 3.826e-05
212 LEARNING 47 131 1.748e-06 3.836e-05
213 ADULT BEHAVIOR 48 135 1.833e-06 4.005e-05
214 POSITIVE REGULATION OF HYDROLASE ACTIVITY 222 905 2.004e-06 4.357e-05
215 COLLAGEN FIBRIL ORGANIZATION 20 38 2.173e-06 4.596e-05
216 RESPONSE TO WOUNDING 148 563 2.15e-06 4.596e-05
217 NEUROTRANSMITTER TRANSPORT 53 155 2.154e-06 4.596e-05
218 REGULATION OF SYNAPSE ORGANIZATION 42 113 2.135e-06 4.596e-05
219 REGULATION OF ACTION POTENTIAL 20 38 2.173e-06 4.596e-05
220 POSITIVE REGULATION OF OSSIFICATION 34 84 2.145e-06 4.596e-05
221 MORPHOGENESIS OF A BRANCHING STRUCTURE 56 167 2.26e-06 4.757e-05
222 MAMMARY GLAND DEVELOPMENT 43 117 2.294e-06 4.808e-05
223 POSITIVE REGULATION OF CELL DEATH 157 605 2.399e-06 5.006e-05
224 REGULATION OF KINASE ACTIVITY 194 776 2.44e-06 5.069e-05
225 POSITIVE REGULATION OF RESPONSE TO STIMULUS 432 1929 2.668e-06 5.517e-05
226 REGULATION OF REPRODUCTIVE PROCESS 46 129 2.719e-06 5.597e-05
227 MUSCLE CELL DIFFERENTIATION 73 237 2.775e-06 5.688e-05
228 RESPONSE TO CORTICOSTEROID 58 176 2.815e-06 5.721e-05
229 POSITIVE REGULATION OF VASCULATURE DEVELOPMENT 47 133 2.84e-06 5.721e-05
230 FATTY ACID METABOLIC PROCESS 87 296 2.835e-06 5.721e-05
231 POSITIVE REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 242 1004 2.832e-06 5.721e-05
232 MEMBRANE DEPOLARIZATION 27 61 3.12e-06 6.231e-05
233 REGULATION OF POTASSIUM ION TRANSMEMBRANE TRANSPORT 27 61 3.12e-06 6.231e-05
234 POSITIVE REGULATION OF CATALYTIC ACTIVITY 348 1518 3.21e-06 6.383e-05
235 OSTEOBLAST DIFFERENTIATION 45 126 3.311e-06 6.555e-05
236 EMBRYONIC ORGAN DEVELOPMENT 112 406 3.479e-06 6.86e-05
237 REGULATION OF CELL DIVISION 81 272 3.543e-06 6.957e-05
238 NEGATIVE REGULATION OF SMOOTH MUSCLE CELL PROLIFERATION 19 36 3.697e-06 7.228e-05
239 REGULATION OF MAPK CASCADE 168 660 3.747e-06 7.265e-05
240 CELL CELL SIGNALING INVOLVED IN CARDIAC CONDUCTION 14 22 3.736e-06 7.265e-05
241 CELL DIVISION 124 460 3.784e-06 7.306e-05
242 RHYTHMIC PROCESS 87 298 3.82e-06 7.344e-05
243 SMALL MOLECULE METABOLIC PROCESS 398 1767 3.85e-06 7.373e-05
244 POSITIVE REGULATION OF CATION TRANSMEMBRANE TRANSPORT 37 97 4.177e-06 7.965e-05
245 MONOVALENT INORGANIC CATION TRANSPORT 118 435 4.66e-06 8.849e-05
246 MORPHOGENESIS OF AN EPITHELIUM 110 400 4.949e-06 9.361e-05
247 NEGATIVE REGULATION OF NEURON DIFFERENTIATION 61 191 4.974e-06 9.37e-05
248 NEGATIVE REGULATION OF NERVOUS SYSTEM DEVELOPMENT 78 262 5.382e-06 0.000101
249 MEMORY 37 98 5.526e-06 0.0001033
250 NEGATIVE REGULATION OF VASCULATURE DEVELOPMENT 32 80 5.703e-06 0.0001058
251 GLIAL CELL DIFFERENTIATION 47 136 5.708e-06 0.0001058
252 DIGESTIVE SYSTEM DEVELOPMENT 50 148 6.074e-06 0.0001121
253 NEGATIVE REGULATION OF CELL CYCLE 117 433 6.227e-06 0.0001145
254 CELL COMMUNICATION INVOLVED IN CARDIAC CONDUCTION 19 37 6.285e-06 0.0001151
255 NEURON MIGRATION 40 110 6.879e-06 0.0001255
256 RESPONSE TO ALKALOID 47 137 7.149e-06 0.0001299
257 CELLULAR RESPONSE TO EXTERNAL STIMULUS 78 264 7.328e-06 0.0001327
258 REGULATION OF TRANSPORTER ACTIVITY 62 198 8.477e-06 0.0001529
259 SISTER CHROMATID COHESION 40 111 8.854e-06 0.0001591
260 RESPONSE TO CALCIUM ION 41 115 9.305e-06 0.0001665
261 NEGATIVE REGULATION OF CELLULAR COMPONENT ORGANIZATION 171 684 9.56e-06 0.0001704
262 ENDOCRINE SYSTEM DEVELOPMENT 43 123 1.008e-05 0.000179
263 REPRODUCTION 299 1297 1.034e-05 0.000183
264 REGULATION OF INTRACELLULAR SIGNAL TRANSDUCTION 372 1656 1.059e-05 0.0001865
265 RESPONSE TO TOXIC SUBSTANCE 72 241 1.062e-05 0.0001865
266 BRANCHING MORPHOGENESIS OF AN EPITHELIAL TUBE 45 131 1.067e-05 0.0001866
267 ARTERY DEVELOPMENT 30 75 1.106e-05 0.000192
268 SENSORY PERCEPTION OF PAIN 30 75 1.106e-05 0.000192
269 ARTERY MORPHOGENESIS 23 51 1.133e-05 0.0001946
270 ORGAN GROWTH 28 68 1.126e-05 0.0001946
271 TUBE MORPHOGENESIS 91 323 1.13e-05 0.0001946
272 FEMALE SEX DIFFERENTIATION 41 116 1.185e-05 0.0002027
273 REGULATION OF CYTOSKELETON ORGANIZATION 131 502 1.196e-05 0.0002038
274 REGULATION OF SYNAPSE ASSEMBLY 31 79 1.259e-05 0.0002138
275 MONOCARBOXYLIC ACID METABOLIC PROCESS 131 503 1.327e-05 0.0002245
276 RESPONSE TO PEPTIDE 109 404 1.367e-05 0.0002304
277 SPROUTING ANGIOGENESIS 21 45 1.415e-05 0.0002378
278 EMBRYO DEVELOPMENT ENDING IN BIRTH OR EGG HATCHING 142 554 1.421e-05 0.0002378
279 REGULATION OF POSTSYNAPTIC MEMBRANE POTENTIAL 24 55 1.464e-05 0.000244
280 RESPIRATORY SYSTEM DEVELOPMENT 61 197 1.468e-05 0.000244
281 ENZYME LINKED RECEPTOR PROTEIN SIGNALING PATHWAY 171 689 1.489e-05 0.0002466
282 POSITIVE REGULATION OF CELLULAR COMPONENT ORGANIZATION 268 1152 1.506e-05 0.0002475
283 NEGATIVE REGULATION OF CELL MORPHOGENESIS INVOLVED IN DIFFERENTIATION 41 117 1.502e-05 0.0002475
284 RESPONSE TO EXTRACELLULAR STIMULUS 117 441 1.549e-05 0.0002538
285 LOCOMOTORY BEHAVIOR 57 181 1.592e-05 0.00026
286 SPINAL CORD DEVELOPMENT 38 106 1.684e-05 0.0002711
287 HINDBRAIN DEVELOPMENT 46 137 1.679e-05 0.0002711
288 SKELETAL MUSCLE ORGAN DEVELOPMENT 46 137 1.679e-05 0.0002711
289 COCHLEA DEVELOPMENT 19 39 1.677e-05 0.0002711
290 REGULATION OF PROTEIN MODIFICATION PROCESS 381 1710 1.79e-05 0.0002872
291 REGULATION OF VASOCONSTRICTION 27 66 1.851e-05 0.0002949
292 REGULATION OF CARDIAC CONDUCTION 27 66 1.851e-05 0.0002949
293 GLOMERULUS DEVELOPMENT 22 49 1.909e-05 0.0003022
294 REGULATION OF SMOOTH MUSCLE CELL MIGRATION 22 49 1.909e-05 0.0003022
295 REGULATION OF OSSIFICATION 56 178 1.942e-05 0.0003063
296 REGULATION OF TRANSMEMBRANE RECEPTOR PROTEIN SERINE THREONINE KINASE SIGNALING PATHWAY 63 207 1.956e-05 0.0003066
297 TELENCEPHALON DEVELOPMENT 68 228 1.957e-05 0.0003066
298 AMEBOIDAL TYPE CELL MIGRATION 50 154 2.082e-05 0.0003251
299 FIBRIL ORGANIZATION 12 19 2.128e-05 0.0003312
300 MEMBRANE DEPOLARIZATION DURING CARDIAC MUSCLE CELL ACTION POTENTIAL 10 14 2.198e-05 0.0003403
301 REGULATION OF PROTEIN LOCALIZATION 225 950 2.202e-05 0.0003403
302 REGULATION OF TRANSFERASE ACTIVITY 224 946 2.333e-05 0.0003594
303 CHROMOSOME SEGREGATION 78 272 2.369e-05 0.0003638
304 REGULATION OF CATECHOLAMINE SECRETION 20 43 2.401e-05 0.0003675
305 POSITIVE REGULATION OF FIBROBLAST PROLIFERATION 23 53 2.449e-05 0.0003737
306 DIVALENT INORGANIC CATION TRANSPORT 77 268 2.477e-05 0.0003766
307 METENCEPHALON DEVELOPMENT 36 100 2.5e-05 0.0003776
308 REGULATION OF SMOOTH MUSCLE CELL PROLIFERATION 36 100 2.5e-05 0.0003776
309 MITOTIC CELL CYCLE 186 766 2.549e-05 0.0003838
310 SECRETION 148 588 2.587e-05 0.0003884
311 REGULATION OF MICROTUBULE BASED PROCESS 71 243 2.762e-05 0.0004133
312 REGULATION OF PEPTIDE TRANSPORT 74 256 2.822e-05 0.0004208
313 SISTER CHROMATID SEGREGATION 55 176 2.833e-05 0.0004212
314 REGULATION OF CELL MORPHOGENESIS 140 552 2.852e-05 0.0004226
315 REGULATION OF CELL SIZE 54 172 2.888e-05 0.0004267
316 POSTSYNAPTIC MEMBRANE ORGANIZATION 14 25 2.974e-05 0.0004379
317 SECOND MESSENGER MEDIATED SIGNALING 51 160 3.027e-05 0.0004442
318 CELLULAR RESPONSE TO INORGANIC SUBSTANCE 50 156 3.061e-05 0.000448
319 RESPONSE TO ETHANOL 45 136 3.118e-05 0.0004537
320 NEGATIVE REGULATION OF CELL PROJECTION ORGANIZATION 47 144 3.122e-05 0.0004537
321 CELLULAR RESPONSE TO PEPTIDE 78 274 3.13e-05 0.0004537
322 NEURAL CREST CELL DIFFERENTIATION 29 75 3.285e-05 0.0004748
323 NEGATIVE REGULATION OF GENE EXPRESSION 335 1493 3.298e-05 0.0004751
324 CALCIUM ION TRANSPORT 66 223 3.354e-05 0.0004816
325 SIGNAL RELEASE 54 173 3.454e-05 0.0004945
326 NEGATIVE REGULATION OF GROWTH 69 236 3.474e-05 0.0004959
327 NERVE DEVELOPMENT 27 68 3.502e-05 0.0004983
328 POSITIVE REGULATION OF SYNAPSE ASSEMBLY 25 61 3.601e-05 0.0005108
329 REGULATION OF STRIATED MUSCLE CONTRACTION 30 79 3.628e-05 0.0005131
330 RESPONSE TO VITAMIN 35 98 3.904e-05 0.0005504
331 REGULATION OF AMINE TRANSPORT 28 72 3.952e-05 0.0005556
332 POSITIVE REGULATION OF KIDNEY DEVELOPMENT 19 41 4.076e-05 0.0005713
333 CALCIUM ION IMPORT 26 65 4.182e-05 0.0005843
334 POSITIVE REGULATION OF TRANSPORTER ACTIVITY 29 76 4.383e-05 0.0006102
335 RESPONSE TO NUTRIENT 58 191 4.393e-05 0.0006102
336 REGULATION OF EMBRYONIC DEVELOPMENT 39 114 4.454e-05 0.0006167
337 MESENCHYME MORPHOGENESIS 18 38 4.502e-05 0.0006217
338 RESPONSE TO ESTRADIOL 47 146 4.614e-05 0.0006352
339 REGULATION OF ERK1 AND ERK2 CASCADE 69 238 4.663e-05 0.00064
340 CELL CELL ADHESION VIA PLASMA MEMBRANE ADHESION MOLECULES 61 204 4.69e-05 0.0006418
341 MITOTIC NUCLEAR DIVISION 97 361 4.707e-05 0.0006423
342 REGULATION OF PROTEIN SERINE THREONINE KINASE ACTIVITY 121 470 4.837e-05 0.0006581
343 POSITIVE REGULATION OF VASOCONSTRICTION 17 35 4.89e-05 0.0006615
344 RESPONSE TO IRON ION 17 35 4.89e-05 0.0006615
345 NEGATIVE REGULATION OF SYNAPTIC TRANSMISSION 25 62 4.983e-05 0.000672
346 MULTI MULTICELLULAR ORGANISM PROCESS 63 213 5.102e-05 0.0006862
347 NEGATIVE REGULATION OF DEVELOPMENTAL GROWTH 31 84 5.162e-05 0.0006922
348 REGULATION OF NUCLEAR DIVISION 51 163 5.24e-05 0.0007007
349 CELLULAR RESPONSE TO EXTRACELLULAR STIMULUS 57 188 5.339e-05 0.0007118
350 CELLULAR RESPONSE TO ALCOHOL 39 115 5.551e-05 0.000738
351 REGULATION OF CARDIAC MUSCLE CONTRACTION 26 66 5.697e-05 0.0007552
352 POSITIVE REGULATION OF REPRODUCTIVE PROCESS 22 52 5.869e-05 0.0007757
353 NEGATIVE REGULATION OF CELL CYCLE PROCESS 63 214 5.946e-05 0.0007837
354 SEX DIFFERENTIATION 75 266 6.211e-05 0.0008164
355 NEGATIVE REGULATION OF CELL ADHESION 65 223 6.378e-05 0.000836
356 ORGANELLE FISSION 126 496 6.491e-05 0.0008484
357 POSITIVE REGULATION OF DEVELOPMENTAL GROWTH 49 156 6.517e-05 0.0008494
358 CELL CELL ADHESION 150 608 6.678e-05 0.0008679
359 EAR MORPHOGENESIS 38 112 6.794e-05 0.0008806
360 RESPONSE TO TRANSFORMING GROWTH FACTOR BETA 46 144 6.822e-05 0.0008818
361 STRIATED MUSCLE CELL DIFFERENTIATION 53 173 7.08e-05 0.0009125
362 CELL CYCLE CHECKPOINT 58 194 7.141e-05 0.0009179
363 REGULATION OF ORGAN MORPHOGENESIS 69 242 8.233e-05 0.001055
364 REGULATION OF MORPHOGENESIS OF A BRANCHING STRUCTURE 22 53 8.295e-05 0.00106
365 AGING 74 264 8.51e-05 0.001085
366 NEGATIVE REGULATION OF CELLULAR RESPONSE TO GROWTH FACTOR STIMULUS 40 121 8.556e-05 0.001086
367 CELL DIFFERENTIATION IN HINDBRAIN 12 21 8.587e-05 0.001086
368 EXTRACELLULAR FIBRIL ORGANIZATION 9 13 8.59e-05 0.001086
369 RESPONSE TO REACTIVE OXYGEN SPECIES 57 191 8.662e-05 0.001092
370 CENTRAL NERVOUS SYSTEM NEURON DIFFERENTIATION 51 166 8.853e-05 0.001113
371 REGULATION OF MEMBRANE REPOLARIZATION 15 30 8.916e-05 0.001118
372 REGULATION OF CARDIAC MUSCLE CELL CONTRACTION 14 27 9.224e-05 0.001154
373 RESPONSE TO PROGESTERONE 21 50 9.761e-05 0.001214
374 ENDODERM FORMATION 21 50 9.761e-05 0.001214
375 CELLULAR RESPONSE TO ACID CHEMICAL 53 175 9.886e-05 0.001227
376 RESPONSE TO FATTY ACID 30 83 0.0001054 0.001305
377 CELLULAR RESPONSE TO STEROID HORMONE STIMULUS 63 218 0.0001076 0.001328
378 REGULATION OF CELL ADHESION 153 629 0.0001184 0.001458
379 POSITIVE REGULATION OF PROTEIN METABOLIC PROCESS 330 1492 0.0001204 0.001479
380 NEGATIVE REGULATION OF AXONOGENESIS 25 65 0.0001242 0.00152
381 REGULATION OF SEQUESTERING OF CALCIUM ION 36 107 0.0001265 0.001545
382 NEPHRON DEVELOPMENT 38 115 0.0001283 0.001563
383 NUCLEAR CHROMOSOME SEGREGATION 65 228 0.0001306 0.001587
384 RESPONSE TO PROSTAGLANDIN 16 34 0.000131 0.001588
385 PERIPHERAL NERVOUS SYSTEM DEVELOPMENT 26 69 0.0001362 0.001646
386 FATTY ACID BETA OXIDATION 21 51 0.0001373 0.00165
387 NEGATIVE REGULATION OF CHEMOTAXIS 21 51 0.0001373 0.00165
388 RESPONSE TO TEMPERATURE STIMULUS 46 148 0.0001415 0.001693
389 RESPONSE TO TRANSITION METAL NANOPARTICLE 46 148 0.0001415 0.001693
390 POSITIVE REGULATION OF CALCIUM ION TRANSMEMBRANE TRANSPORTER ACTIVITY 15 31 0.0001434 0.001706
391 REGULATION OF SYNAPTIC VESICLE TRANSPORT 15 31 0.0001434 0.001706
392 SECRETION BY CELL 122 486 0.000144 0.001709
393 EYE DEVELOPMENT 87 326 0.000145 0.001717
394 CELL CYCLE PHASE TRANSITION 71 255 0.0001463 0.001727
395 PANCREAS DEVELOPMENT 27 73 0.0001471 0.001733
396 REGULATION OF HYDROLASE ACTIVITY 296 1327 0.0001481 0.001741
397 EPITHELIAL CELL DEVELOPMENT 55 186 0.0001488 0.001744
398 REACTIVE OXYGEN SPECIES METABOLIC PROCESS 33 96 0.0001498 0.001751
399 PRESYNAPTIC PROCESS INVOLVED IN SYNAPTIC TRANSMISSION 38 116 0.0001572 0.001825
400 SYNAPTIC TRANSMISSION GLUTAMATERGIC 12 22 0.0001572 0.001825
401 POSITIVE REGULATION OF CHEMOTAXIS 39 120 0.0001567 0.001825
402 DNA STRAND ELONGATION INVOLVED IN DNA REPLICATION 13 25 0.0001586 0.001836
403 REGULATION OF KIDNEY DEVELOPMENT 22 55 0.0001595 0.001842
404 PHENOL CONTAINING COMPOUND METABOLIC PROCESS 29 81 0.0001654 0.001904
405 NEGATIVE REGULATION OF RESPONSE TO EXTERNAL STIMULUS 75 274 0.0001738 0.001997
406 REGULATION OF RENAL SYSTEM PROCESS 17 38 0.0001765 0.002023
407 REGULATION OF EPITHELIAL CELL MIGRATION 50 166 0.0001776 0.00203
408 NITROGEN COMPOUND TRANSPORT 126 507 0.0001782 0.002033
409 POSITIVE REGULATION OF CALCIUM ION TRANSMEMBRANE TRANSPORT 23 59 0.0001806 0.002054
410 POSITIVE REGULATION OF PURINE NUCLEOTIDE METABOLIC PROCESS 42 133 0.0001834 0.002071
411 CELL CHEMOTAXIS 49 162 0.0001833 0.002071
412 POSITIVE REGULATION OF NUCLEOTIDE METABOLIC PROCESS 42 133 0.0001834 0.002071
413 EMBRYONIC ORGAN MORPHOGENESIS 76 279 0.0001862 0.002098
414 AMIDE TRANSPORT 33 97 0.0001873 0.002105
415 CENTROSOME CYCLE 19 45 0.0001908 0.002139
416 OVULATION CYCLE 37 113 0.0001926 0.002154
417 RESPONSE TO ESTROGEN 62 218 0.0001981 0.00221
418 RESPONSE TO MONOAMINE 16 35 0.0002002 0.002229
419 POSITIVE REGULATION OF METANEPHROS DEVELOPMENT 9 14 0.000201 0.002232
420 SKELETAL SYSTEM MORPHOGENESIS 58 201 0.000206 0.002283
421 REGULATION OF CANONICAL WNT SIGNALING PATHWAY 66 236 0.0002139 0.002365
422 REGULATION OF PROTEIN SECRETION 100 389 0.0002219 0.002447
423 NEGATIVE REGULATION OF POTASSIUM ION TRANSPORT 15 32 0.000224 0.002458
424 REGULATION OF ACTIN FILAMENT BASED MOVEMENT 15 32 0.000224 0.002458
425 POSITIVE REGULATION OF KINASE ACTIVITY 120 482 0.0002324 0.002545
426 RENAL SYSTEM PROCESS 34 102 0.000235 0.002567
427 REGULATION OF SMOOTH MUSCLE CONTRACTION 23 60 0.0002421 0.002632
428 STEM CELL PROLIFERATION 23 60 0.0002421 0.002632
429 REGULATION OF RESPONSE TO WOUNDING 105 413 0.0002451 0.002652
430 RESPONSE TO RADIATION 105 413 0.0002451 0.002652
431 RESPONSE TO PAIN 14 29 0.000246 0.002656
432 NEGATIVE REGULATION OF NITROGEN COMPOUND METABOLIC PROCESS 332 1517 0.0002581 0.00278
433 REGULATION OF CENTROSOME CYCLE 17 39 0.0002594 0.002781
434 NEGATIVE CHEMOTAXIS 17 39 0.0002594 0.002781
435 CYTOSOLIC CALCIUM ION TRANSPORT 21 53 0.0002611 0.002793
436 POSITIVE REGULATION OF DENDRITE DEVELOPMENT 24 64 0.0002646 0.002804
437 REGULATION OF NEUROTRANSMITTER TRANSPORT 24 64 0.0002646 0.002804
438 RESPONSE TO CORTICOSTERONE 13 26 0.0002638 0.002804
439 CELLULAR RESPONSE TO VITAMIN 13 26 0.0002638 0.002804
440 RESPONSE TO COCAINE 19 46 0.0002692 0.002847
441 INNERVATION 12 23 0.0002735 0.002879
442 DEVELOPMENT OF PRIMARY SEXUAL CHARACTERISTICS 61 216 0.0002731 0.002879
443 CARBOHYDRATE DERIVATIVE METABOLIC PROCESS 237 1047 0.0002777 0.002917
444 MULTICELLULAR ORGANISMAL RESPONSE TO STRESS 25 68 0.0002844 0.002981
445 REGULATION OF BLOOD PRESSURE 50 169 0.0002859 0.002989
446 HEART MORPHOGENESIS 60 212 0.0002865 0.002989
447 CELL CYCLE G1 S PHASE TRANSITION 36 111 0.000288 0.002991
448 G1 S TRANSITION OF MITOTIC CELL CYCLE 36 111 0.000288 0.002991
449 REGULATION OF WNT SIGNALING PATHWAY 82 310 0.0003005 0.003115
450 CARBOXYLIC ACID BIOSYNTHETIC PROCESS 73 270 0.0003138 0.003238
451 ORGANIC ACID BIOSYNTHETIC PROCESS 73 270 0.0003138 0.003238
452 REGULATION OF MUSCLE CELL APOPTOTIC PROCESS 18 43 0.0003182 0.003275
453 HEPATICOBILIARY SYSTEM DEVELOPMENT 40 128 0.0003285 0.003366
454 MUSCLE CELL DEVELOPMENT 40 128 0.0003285 0.003366
455 NEGATIVE REGULATION OF CELL GROWTH 50 170 0.0003334 0.00341
456 AMINO ACID TRANSPORT 39 124 0.000335 0.003419
457 REGULATION OF LEUKOCYTE MIGRATION 45 149 0.0003407 0.003463
458 REGULATION OF DENDRITE DEVELOPMENT 38 120 0.0003409 0.003463
459 REGULATION OF CALCIUM ION TRANSMEMBRANE TRANSPORT 37 116 0.0003459 0.003499
460 REGULATION OF CATION CHANNEL ACTIVITY 30 88 0.0003452 0.003499
461 ORGANIC HYDROXY COMPOUND METABOLIC PROCESS 119 482 0.00035 0.003528
462 INNER EAR MORPHOGENESIS 31 92 0.0003503 0.003528
463 RESPONSE TO IONIZING RADIATION 44 145 0.0003516 0.003533
464 TRANSMISSION OF NERVE IMPULSE 21 54 0.0003536 0.003546
465 REGULATION OF NEURON APOPTOTIC PROCESS 55 192 0.0003616 0.003618
466 REGULATION OF CELL CYCLE PROCESS 135 558 0.0003686 0.003681
467 ENDODERMAL CELL DIFFERENTIATION 17 40 0.0003741 0.003722
468 PRIMARY ALCOHOL METABOLIC PROCESS 19 47 0.0003743 0.003722
469 CEREBELLAR CORTEX MORPHOGENESIS 14 30 0.0003833 0.003763
470 NEGATIVE REGULATION OF MUSCLE CELL APOPTOTIC PROCESS 14 30 0.0003833 0.003763
471 BROWN FAT CELL DIFFERENTIATION 14 30 0.0003833 0.003763
472 DNA STRAND ELONGATION 14 30 0.0003833 0.003763
473 MODULATION OF EXCITATORY POSTSYNAPTIC POTENTIAL 14 30 0.0003833 0.003763
474 REGULATION OF DENDRITIC SPINE MORPHOGENESIS 14 30 0.0003833 0.003763
475 POSITIVE REGULATION OF EPITHELIAL CELL PROLIFERATION 46 154 0.0003872 0.003793
476 NEUROTRANSMITTER UPTAKE 9 15 0.0004199 0.004088
477 NEGATIVE REGULATION OF GLYCOPROTEIN METABOLIC PROCESS 9 15 0.0004199 0.004088
478 VENTRICULAR CARDIAC MUSCLE CELL ACTION POTENTIAL 9 15 0.0004199 0.004088
479 PALATE DEVELOPMENT 29 85 0.0004235 0.004097
480 CARDIAC VENTRICLE MORPHOGENESIS 23 62 0.0004226 0.004097
481 CENTRAL NERVOUS SYSTEM NEURON AXONOGENESIS 13 27 0.0004231 0.004097
482 REGULATION OF NEUROTRANSMITTER SECRETION 20 51 0.0004264 0.004108
483 NEURAL CREST CELL MIGRATION 20 51 0.0004264 0.004108
484 POSITIVE REGULATION OF CYCLIC NUCLEOTIDE METABOLIC PROCESS 35 109 0.0004287 0.004122
485 RESPONSE TO HEAT 30 89 0.0004299 0.004124
486 POSITIVE REGULATION OF CATION CHANNEL ACTIVITY 16 37 0.0004371 0.004168
487 GLIAL CELL MIGRATION 16 37 0.0004371 0.004168
488 IMPORT INTO CELL 16 37 0.0004371 0.004168
489 CARDIAC EPITHELIAL TO MESENCHYMAL TRANSITION 12 24 0.0004554 0.004333
490 REGULATION OF COLLATERAL SPROUTING 10 18 0.0004651 0.004399
491 OSTEOBLAST DEVELOPMENT 10 18 0.0004651 0.004399
492 UTERUS DEVELOPMENT 10 18 0.0004651 0.004399
493 POSITIVE REGULATION OF RESPONSE TO EXTERNAL STIMULUS 78 296 0.00047 0.004436
494 SIALYLATION 11 21 0.0004728 0.004453
495 LIPID OXIDATION 25 70 0.0004741 0.004456
496 POSITIVE REGULATION OF GROWTH 65 238 0.0004833 0.004534
497 CELL SUBSTRATE ADHESION 48 164 0.0004893 0.004579
498 POSITIVE REGULATION OF CELL CYCLE PROCESS 67 247 0.0004901 0.004579
499 ACTIN MEDIATED CELL CONTRACTION 26 74 0.0004933 0.0046
500 TRANSMEMBRANE RECEPTOR PROTEIN SERINE THREONINE KINASE SIGNALING PATHWAY 54 190 0.0005012 0.004665
501 RESPONSE TO AXON INJURY 19 48 0.0005133 0.004758
502 DIGESTIVE TRACT MORPHOGENESIS 19 48 0.0005133 0.004758
503 FORMATION OF PRIMARY GERM LAYER 35 110 0.0005187 0.004798
504 INTRACELLULAR SIGNAL TRANSDUCTION 340 1572 0.0005232 0.00483
505 MITOTIC RECOMBINATION 17 41 0.0005301 0.004884
506 CELL GROWTH 41 135 0.000538 0.004947
507 REGULATION OF GTPASE ACTIVITY 158 673 0.0005414 0.004968
508 REGULATION OF RESPONSE TO EXTERNAL STIMULUS 210 926 0.0005485 0.005024
509 REGULATION OF CARTILAGE DEVELOPMENT 23 63 0.0005506 0.005033
510 PEPTIDYL SERINE MODIFICATION 44 148 0.0005716 0.005215
511 ENDODERM DEVELOPMENT 25 71 0.0006049 0.005508
512 NEGATIVE REGULATION OF EPITHELIAL CELL PROLIFERATION 36 115 0.0006129 0.005567
513 CARDIAC MUSCLE TISSUE DEVELOPMENT 42 140 0.0006138 0.005567
514 REGULATION OF DENDRITIC SPINE DEVELOPMENT 21 56 0.0006271 0.005655
515 COLUMNAR CUBOIDAL EPITHELIAL CELL DIFFERENTIATION 35 111 0.0006249 0.005655
516 OUTFLOW TRACT MORPHOGENESIS 21 56 0.0006271 0.005655
517 CELL FATE COMMITMENT 62 227 0.0006416 0.005773
518 HOMOPHILIC CELL ADHESION VIA PLASMA MEMBRANE ADHESION MOLECULES 45 153 0.0006426 0.005773
519 POSITIVE REGULATION OF EPITHELIAL CELL MIGRATION 33 103 0.000644 0.005774
520 PHOSPHOLIPASE C ACTIVATING G PROTEIN COUPLED RECEPTOR SIGNALING PATHWAY 28 83 0.000648 0.005798
521 STRIATED MUSCLE CONTRACTION 32 99 0.0006505 0.00581
522 GLUTAMATE SECRETION 13 28 0.000657 0.005812
523 ENSHEATHMENT OF NEURONS 30 91 0.0006558 0.005812
524 AXON ENSHEATHMENT 30 91 0.0006558 0.005812
525 REGULATION OF FATTY ACID OXIDATION 13 28 0.000657 0.005812
526 NEURONAL ACTION POTENTIAL 13 28 0.000657 0.005812
527 AMINOGLYCAN METABOLIC PROCESS 48 166 0.0006584 0.005814
528 CHONDROCYTE DIFFERENTIATION 22 60 0.0006728 0.005918
529 POSITIVE REGULATION OF OSTEOBLAST DIFFERENTIATION 22 60 0.0006728 0.005918
530 POSITIVE REGULATION OF CELL MORPHOGENESIS INVOLVED IN DIFFERENTIATION 47 162 0.0006876 0.006036
531 CELLULAR RESPONSE TO CALCIUM ION 19 49 0.0006947 0.006088
532 MICROTUBULE DEPOLYMERIZATION 8 13 0.00071 0.006186
533 BEHAVIORAL RESPONSE TO PAIN 8 13 0.00071 0.006186
534 NEGATIVE REGULATION OF CARDIAC MUSCLE CELL APOPTOTIC PROCESS 8 13 0.00071 0.006186
535 POSITIVE REGULATION OF CELL CYCLE 85 332 0.0007199 0.006261
536 RESPONSE TO PROSTAGLANDIN E 12 25 0.0007293 0.006319
537 GLYCOSPHINGOLIPID BIOSYNTHETIC PROCESS 12 25 0.0007293 0.006319
538 AUTONOMIC NERVOUS SYSTEM DEVELOPMENT 17 42 0.0007387 0.006377
539 EPITHELIAL CELL MORPHOGENESIS 17 42 0.0007387 0.006377
540 REGULATION OF OSTEOBLAST DIFFERENTIATION 35 112 0.0007499 0.006462
541 NEGATIVE REGULATION OF CELL SUBSTRATE ADHESION 20 53 0.0007634 0.006566
542 MUCOPOLYSACCHARIDE METABOLIC PROCESS 34 108 0.0007652 0.006569
543 IMMUNE SYSTEM DEVELOPMENT 138 582 0.0007743 0.006635
544 CARDIAC CHAMBER MORPHOGENESIS 33 104 0.0007786 0.006645
545 GLIAL CELL DEVELOPMENT 26 76 0.000784 0.006645
546 REGULATION OF BODY FLUID LEVELS 122 506 0.0007889 0.006645
547 REGULATION OF DOPAMINE SECRETION 11 22 0.0007884 0.006645
548 ENDOCARDIAL CUSHION MORPHOGENESIS 11 22 0.0007884 0.006645
549 CENTRAL NERVOUS SYSTEM PROJECTION NEURON AXONOGENESIS 11 22 0.0007884 0.006645
550 POSITIVE REGULATION OF PROTEIN MODIFICATION PROCESS 251 1135 0.0007878 0.006645
551 POSITIVE REGULATION OF TRANSMEMBRANE RECEPTOR PROTEIN SERINE THREONINE KINASE SIGNALING PATHWAY 32 100 0.0007897 0.006645
552 REGULATION OF STRIATED MUSCLE CELL APOPTOTIC PROCESS 11 22 0.0007884 0.006645
553 POSITIVE REGULATION OF MESONEPHROS DEVELOPMENT 11 22 0.0007884 0.006645
554 REGULATION OF LEUKOCYTE CHEMOTAXIS 31 96 0.0007982 0.006692
555 POSITIVE REGULATION OF SECRETION 93 370 0.0007979 0.006692
556 NEGATIVE REGULATION OF SMOOTH MUSCLE CELL MIGRATION 9 16 0.0008027 0.006693
557 NEURON CELL CELL ADHESION 9 16 0.0008027 0.006693
558 RESPONSE TO EPINEPHRINE 9 16 0.0008027 0.006693
559 NEGATIVE REGULATION OF CELL CYCLE PHASE TRANSITION 43 146 0.0008111 0.006751
560 REGULATION OF CELLULAR RESPONSE TO GROWTH FACTOR STIMULUS 62 229 0.0008182 0.006751
561 ALPHA AMINO ACID METABOLIC PROCESS 62 229 0.0008182 0.006751
562 REGULATION OF ALPHA AMINO 3 HYDROXY 5 METHYL 4 ISOXAZOLE PROPIONATE SELECTIVE GLUTAMATE RECEPTOR ACTIVITY 10 19 0.0008198 0.006751
563 REGULATION OF CARDIAC MUSCLE CELL ACTION POTENTIAL 10 19 0.0008198 0.006751
564 LIVER REGENERATION 10 19 0.0008198 0.006751
565 REGULATION OF BINDING 74 283 0.000818 0.006751
566 CYCLIC NUCLEOTIDE METABOLIC PROCESS 21 57 0.0008221 0.006758
567 CALCIUM ION TRANSMEMBRANE TRANSPORT 46 159 0.0008317 0.006825
568 CEREBELLAR CORTEX DEVELOPMENT 18 46 0.0008399 0.006844
569 CYCLIC NUCLEOTIDE MEDIATED SIGNALING 18 46 0.0008399 0.006844
570 REGULATION OF CHONDROCYTE DIFFERENTIATION 18 46 0.0008399 0.006844
571 MONOCARBOXYLIC ACID BIOSYNTHETIC PROCESS 49 172 0.0008378 0.006844
572 NEGATIVE REGULATION OF PHOSPHORYLATION 104 422 0.0008493 0.006909
573 POSITIVE REGULATION OF HOMEOSTATIC PROCESS 59 216 0.0008523 0.006921
574 NEGATIVE REGULATION OF LEUKOCYTE MIGRATION 14 32 0.0008586 0.006948
575 POSITIVE REGULATION OF AMINE TRANSPORT 14 32 0.0008586 0.006948
576 REGULATION OF PHOSPHOLIPASE C ACTIVITY 16 39 0.000882 0.0071
577 REGULATION OF AXON GUIDANCE 16 39 0.000882 0.0071
578 LONG TERM SYNAPTIC POTENTIATION 16 39 0.000882 0.0071
579 HORMONE METABOLIC PROCESS 47 164 0.0009191 0.007386
580 NEGATIVE REGULATION OF MITOTIC CELL CYCLE 55 199 0.0009288 0.007451
581 RESPONSE TO ACTIVITY 24 69 0.0009411 0.007537
582 DNA REPLICATION 57 208 0.0009485 0.007583
583 POSITIVE REGULATION OF PROTEIN SERINE THREONINE KINASE ACTIVITY 75 289 0.0009534 0.007609
584 FATTY ACID CATABOLIC PROCESS 25 73 0.0009636 0.007664
585 CELLULAR RESPONSE TO KETONE 25 73 0.0009636 0.007664
586 ACTIN FILAMENT BASED MOVEMENT 30 93 0.0009797 0.007752
587 REGULATION OF SODIUM ION TRANSPORT 26 77 0.0009786 0.007752
588 REGULATION OF DNA BINDING 30 93 0.0009797 0.007752
589 METANEPHROS DEVELOPMENT 27 81 0.000987 0.007776
590 REGULATION OF FIBROBLAST PROLIFERATION 27 81 0.000987 0.007776
591 REGULATION OF THE FORCE OF HEART CONTRACTION 13 29 0.000991 0.007776
592 DNA REPLICATION INITIATION 13 29 0.000991 0.007776
593 HEART PROCESS 28 85 0.0009895 0.007776
594 NEUROMUSCULAR JUNCTION DEVELOPMENT 15 36 0.001049 0.008189
595 SULFUR COMPOUND METABOLIC PROCESS 90 359 0.001045 0.008189
596 ORGANIC ANION TRANSPORT 96 387 0.00105 0.008189
597 REGULATION OF MICROTUBULE POLYMERIZATION OR DEPOLYMERIZATION 50 178 0.001051 0.008189
598 NEGATIVE REGULATION OF NEURON APOPTOTIC PROCESS 40 135 0.001065 0.008283
599 NEGATIVE REGULATION OF TRANSPORT 111 458 0.001094 0.008496
600 POSITIVE REGULATION OF CELL GROWTH 43 148 0.001098 0.008513
601 GANGLIOSIDE METABOLIC PROCESS 12 26 0.001128 0.008677
602 REGULATION OF MESONEPHROS DEVELOPMENT 12 26 0.001128 0.008677
603 NEGATIVE REGULATION OF CARTILAGE DEVELOPMENT 12 26 0.001128 0.008677
604 CARDIAC VENTRICLE DEVELOPMENT 33 106 0.001123 0.008677
605 NEGATIVE REGULATION OF EMBRYONIC DEVELOPMENT 12 26 0.001128 0.008677
606 CARBOXYLIC ACID CATABOLIC PROCESS 56 205 0.001133 0.008686
607 ORGANIC ACID CATABOLIC PROCESS 56 205 0.001133 0.008686
608 CARDIAC CHAMBER DEVELOPMENT 42 144 0.001145 0.008756
609 REGULATION OF G PROTEIN COUPLED RECEPTOR PROTEIN SIGNALING PATHWAY 38 127 0.001146 0.008756
610 REGULATION OF MITOTIC SPINDLE CHECKPOINT 7 11 0.001194 0.009016
611 SINGLE ORGANISM CELL ADHESION 111 459 0.001185 0.009016
612 NEGATIVE REGULATION OF FIBROBLAST GROWTH FACTOR RECEPTOR SIGNALING PATHWAY 7 11 0.001194 0.009016
613 INNER CELL MASS CELL PROLIFERATION 7 11 0.001194 0.009016
614 REGULATION OF VENTRICULAR CARDIAC MUSCLE CELL ACTION POTENTIAL 7 11 0.001194 0.009016
615 EPITHELIAL TO MESENCHYMAL TRANSITION INVOLVED IN ENDOCARDIAL CUSHION FORMATION 7 11 0.001194 0.009016
616 REGULATION OF MITOTIC CELL CYCLE SPINDLE ASSEMBLY CHECKPOINT 7 11 0.001194 0.009016
617 MESONEPHROS DEVELOPMENT 29 90 0.001203 0.009072
618 RENAL TUBULE DEVELOPMENT 26 78 0.001214 0.009129
619 PALLIUM DEVELOPMENT 44 153 0.001216 0.009129
620 KIDNEY MORPHOGENESIS 27 82 0.001216 0.009129
621 ENDOCRINE PANCREAS DEVELOPMENT 16 40 0.001221 0.009146
622 CELL MATRIX ADHESION 36 119 0.001227 0.009177
623 ANION TRANSPORT 121 507 0.00123 0.009186
624 NEURON RECOGNITION 14 33 0.00124 0.009232
625 EMBRYONIC DIGESTIVE TRACT DEVELOPMENT 14 33 0.00124 0.009232
626 CGMP METABOLIC PROCESS 11 23 0.00126 0.009323
627 RESPONSE TO INCREASED OXYGEN LEVELS 11 23 0.00126 0.009323
628 REGULATION OF METANEPHROS DEVELOPMENT 11 23 0.00126 0.009323
629 RESPONSE TO HYPEROXIA 11 23 0.00126 0.009323
630 NEGATIVE REGULATION OF PHOSPHORUS METABOLIC PROCESS 128 541 0.00128 0.009442
631 NEGATIVE REGULATION OF PHOSPHATE METABOLIC PROCESS 128 541 0.00128 0.009442
632 POSITIVE REGULATION OF MAPK CASCADE 113 470 0.001336 0.009835
NumGOOverlapSizeP ValueAdj. P Value
1 GATED CHANNEL ACTIVITY 115 325 2.499e-13 2.322e-10
2 METAL ION TRANSMEMBRANE TRANSPORTER ACTIVITY 133 417 1.988e-11 9.233e-09
3 PASSIVE TRANSMEMBRANE TRANSPORTER ACTIVITY 143 464 5.654e-11 1.751e-08
4 TRANSMEMBRANE TRANSPORTER ACTIVITY 264 997 9.828e-11 2.283e-08
5 CATION CHANNEL ACTIVITY 100 298 2.817e-10 5.234e-08
6 TRANSPORTER ACTIVITY 322 1276 3.398e-10 5.261e-08
7 RECEPTOR BINDING 364 1476 4.431e-10 5.88e-08
8 RNA POLYMERASE II TRANSCRIPTION FACTOR ACTIVITY SEQUENCE SPECIFIC DNA BINDING 178 629 6.172e-10 7.167e-08
9 CATION TRANSMEMBRANE TRANSPORTER ACTIVITY 175 622 1.396e-09 1.441e-07
10 NUCLEIC ACID BINDING TRANSCRIPTION FACTOR ACTIVITY 301 1199 2.392e-09 2.223e-07
11 TRANSCRIPTION FACTOR ACTIVITY RNA POLYMERASE II CORE PROMOTER PROXIMAL REGION SEQUENCE SPECIFIC BINDING 104 328 4.351e-09 3.675e-07
12 CYTOSKELETAL PROTEIN BINDING 216 819 7.608e-09 5.048e-07
13 CALCIUM ION BINDING 189 697 7.223e-09 5.048e-07
14 DOUBLE STRANDED DNA BINDING 204 764 6.998e-09 5.048e-07
15 GLYCOSAMINOGLYCAN BINDING 72 205 1.007e-08 6.236e-07
16 VOLTAGE GATED ION CHANNEL ACTIVITY 68 190 1.077e-08 6.252e-07
17 INORGANIC CATION TRANSMEMBRANE TRANSPORTER ACTIVITY 149 527 1.653e-08 9.034e-07
18 REGULATORY REGION NUCLEIC ACID BINDING 214 818 1.81e-08 9.341e-07
19 PROTEIN COMPLEX BINDING 238 935 3.596e-08 1.758e-06
20 SEQUENCE SPECIFIC DNA BINDING 258 1037 8.176e-08 3.798e-06
21 EXTRACELLULAR MATRIX STRUCTURAL CONSTITUENT 34 76 1.249e-07 5.525e-06
22 TRANSCRIPTIONAL ACTIVATOR ACTIVITY RNA POLYMERASE II TRANSCRIPTION REGULATORY REGION SEQUENCE SPECIFIC BINDING 96 315 1.424e-07 6.015e-06
23 MACROMOLECULAR COMPLEX BINDING 332 1399 1.904e-07 7.69e-06
24 TUBULIN BINDING 85 273 2.64e-07 1.022e-05
25 SULFUR COMPOUND BINDING 75 234 3.716e-07 1.328e-05
26 CELL ADHESION MOLECULE BINDING 63 186 3.641e-07 1.328e-05
27 IDENTICAL PROTEIN BINDING 290 1209 4.465e-07 1.536e-05
28 MONOVALENT INORGANIC CATION TRANSMEMBRANE TRANSPORTER ACTIVITY 106 366 5.407e-07 1.794e-05
29 LIGAND GATED CHANNEL ACTIVITY 51 142 6.236e-07 1.998e-05
30 TRANSCRIPTIONAL ACTIVATOR ACTIVITY RNA POLYMERASE II CORE PROMOTER PROXIMAL REGION SEQUENCE SPECIFIC BINDING 72 226 8.128e-07 2.517e-05
31 VOLTAGE GATED POTASSIUM CHANNEL ACTIVITY 36 89 1.109e-06 3.324e-05
32 VOLTAGE GATED CATION CHANNEL ACTIVITY 48 134 1.436e-06 4.044e-05
33 HEPARIN BINDING 54 157 1.413e-06 4.044e-05
34 INTEGRIN BINDING 40 105 1.8e-06 4.918e-05
35 POTASSIUM ION TRANSMEMBRANE TRANSPORTER ACTIVITY 50 143 1.983e-06 5.265e-05
36 SODIUM ION TRANSMEMBRANE TRANSPORTER ACTIVITY 48 136 2.33e-06 6.013e-05
37 POTASSIUM CHANNEL ACTIVITY 43 120 4.908e-06 0.0001232
38 CHANNEL REGULATOR ACTIVITY 45 131 1.067e-05 0.0002591
39 CORE PROMOTER PROXIMAL REGION DNA BINDING 102 371 1.088e-05 0.0002591
40 STEROID HORMONE RECEPTOR ACTIVITY 25 59 1.818e-05 0.000412
41 DELAYED RECTIFIER POTASSIUM CHANNEL ACTIVITY 18 36 1.776e-05 0.000412
42 SOLUTE SODIUM SYMPORTER ACTIVITY 22 51 4.096e-05 0.0009059
43 MICROTUBULE BINDING 60 201 5.687e-05 0.001229
44 HYDROLASE ACTIVITY ACTING ON ACID ANHYDRIDES 194 820 8.539e-05 0.001803
45 CHEMOREPELLENT ACTIVITY 14 27 9.224e-05 0.001904
46 COLLAGEN BINDING 25 65 0.0001242 0.002427
47 MOLECULAR FUNCTION REGULATOR 302 1353 0.0001208 0.002427
48 ION CHANNEL BINDING 37 111 0.0001277 0.002427
49 GROWTH FACTOR BINDING 40 123 0.000128 0.002427
50 FATTY ACYL COA BINDING 15 31 0.0001434 0.002649
51 PROTEIN DIMERIZATION ACTIVITY 260 1149 0.0001454 0.002649
52 SCAFFOLD PROTEIN BINDING 19 45 0.0001908 0.003353
53 FLAVIN ADENINE DINUCLEOTIDE BINDING 27 74 0.0001913 0.003353
54 ACTIVE TRANSMEMBRANE TRANSPORTER ACTIVITY 93 356 0.0001991 0.003425
55 PHOSPHORIC DIESTER HYDROLASE ACTIVITY 31 90 0.0002249 0.003798
56 G PROTEIN COUPLED RECEPTOR BINDING 71 259 0.0002428 0.004028
57 VOLTAGE GATED SODIUM CHANNEL ACTIVITY 11 20 0.0002701 0.004326
58 EXTRACELLULAR GLUTAMATE GATED ION CHANNEL ACTIVITY 11 20 0.0002701 0.004326
59 PROTEIN HOMODIMERIZATION ACTIVITY 170 722 0.000293 0.004614
60 COENZYME BINDING 52 179 0.000357 0.005527
61 COFACTOR BINDING 71 263 0.0003941 0.006002
62 PROTEIN LIPID COMPLEX BINDING 12 24 0.0004554 0.006757
63 TRANSCRIPTIONAL REPRESSOR ACTIVITY RNA POLYMERASE II TRANSCRIPTION REGULATORY REGION SEQUENCE SPECIFIC BINDING 49 168 0.0004696 0.006757
64 ATP DEPENDENT MICROTUBULE MOTOR ACTIVITY 10 18 0.0004651 0.006757
65 SIALYLTRANSFERASE ACTIVITY 11 21 0.0004728 0.006757
66 TRANSCRIPTION FACTOR ACTIVITY DIRECT LIGAND REGULATED SEQUENCE SPECIFIC DNA BINDING 19 48 0.0005133 0.007225
67 WNT PROTEIN BINDING 14 31 0.0005809 0.008055
68 EXTRACELLULAR LIGAND GATED ION CHANNEL ACTIVITY 26 75 0.000624 0.008525
69 STEROID BINDING 30 91 0.0006558 0.008802
70 CALMODULIN BINDING 51 179 0.0006632 0.008802
71 RAS GUANYL NUCLEOTIDE EXCHANGE FACTOR ACTIVITY 62 228 0.0007251 0.00941
72 NEUROTRANSMITTER TRANSPORTER ACTIVITY 12 25 0.0007293 0.00941
NumGOOverlapSizeP ValueAdj. P Value
1 PROTEINACEOUS EXTRACELLULAR MATRIX 157 356 2.654e-29 1.55e-26
2 EXTRACELLULAR MATRIX 176 426 1.609e-28 4.697e-26
3 NEURON PART 390 1265 2.867e-28 5.582e-26
4 NEURON PROJECTION 307 942 1.194e-26 1.744e-24
5 SYNAPSE 248 754 2.958e-22 3.454e-20
6 INTRINSIC COMPONENT OF PLASMA MEMBRANE 455 1649 1.301e-21 1.266e-19
7 SOMATODENDRITIC COMPARTMENT 215 650 9.63e-20 8.034e-18
8 SYNAPSE PART 203 610 4.934e-19 3.602e-17
9 AXON 151 418 5.244e-18 3.403e-16
10 CELL PROJECTION 469 1786 8.887e-18 5.19e-16
11 CELL BODY 168 494 5.923e-17 3.145e-15
12 MEMBRANE REGION 319 1134 1.586e-16 7.718e-15
13 PLASMA MEMBRANE REGION 271 929 2.812e-16 1.263e-14
14 EXTRACELLULAR MATRIX COMPONENT 61 125 1.123e-14 4.685e-13
15 POSTSYNAPSE 132 378 1.37e-14 5.333e-13
16 DENDRITE 150 451 2.328e-14 8.496e-13
17 CELL JUNCTION 311 1151 1.239e-13 4.257e-12
18 COLLAGEN TRIMER 47 88 1.737e-13 5.634e-12
19 CELL PROJECTION PART 264 946 2.122e-13 6.523e-12
20 CATION CHANNEL COMPLEX 70 167 1.616e-12 4.719e-11
21 SYNAPTIC MEMBRANE 96 261 1.788e-12 4.972e-11
22 COMPLEX OF COLLAGEN TRIMERS 19 23 4.551e-11 1.172e-09
23 TRANSPORTER COMPLEX 108 321 4.616e-11 1.172e-09
24 AXON PART 81 219 6.897e-11 1.678e-09
25 EXCITATORY SYNAPSE 74 197 1.984e-10 4.634e-09
26 BASEMENT MEMBRANE 43 93 7.923e-10 1.726e-08
27 PLASMA MEMBRANE PROTEIN COMPLEX 150 510 7.978e-10 1.726e-08
28 EXTRACELLULAR SPACE 339 1376 2.108e-09 4.396e-08
29 CELL SURFACE 204 757 3.136e-09 6.315e-08
30 POSTSYNAPTIC MEMBRANE 72 205 1.007e-08 1.96e-07
31 POTASSIUM CHANNEL COMPLEX 40 90 1.251e-08 2.357e-07
32 NEURON PROJECTION TERMINUS 51 129 1.756e-08 3.205e-07
33 PERIKARYON 44 108 5.802e-08 1.027e-06
34 PRESYNAPSE 89 283 8.428e-08 1.448e-06
35 NEURONAL POSTSYNAPTIC DENSITY 26 53 4.077e-07 6.803e-06
36 CHROMOSOME CENTROMERIC REGION 59 174 8.09e-07 1.312e-05
37 I BAND 44 121 2.445e-06 3.859e-05
38 MAIN AXON 26 58 3.542e-06 5.444e-05
39 KINETOCHORE 43 120 4.908e-06 7.349e-05
40 CELL CELL JUNCTION 106 383 5.367e-06 7.836e-05
41 MEMBRANE MICRODOMAIN 84 288 5.794e-06 8.253e-05
42 ENDOPLASMIC RETICULUM LUMEN 63 201 6.957e-06 9.673e-05
43 PRESYNAPTIC ACTIVE ZONE 16 29 1.031e-05 0.00014
44 SARCOPLASM 28 68 1.126e-05 0.0001494
45 NEURON SPINE 42 121 1.551e-05 0.0002013
46 CONDENSED CHROMOSOME CENTROMERIC REGION 37 102 1.596e-05 0.0002026
47 CONTRACTILE FIBER 64 211 1.899e-05 0.0002359
48 CYTOSKELETON 432 1967 2.053e-05 0.0002498
49 CONDENSED CHROMOSOME 60 195 2.123e-05 0.000253
50 IONOTROPIC GLUTAMATE RECEPTOR COMPLEX 21 47 3.217e-05 0.0003684
51 BANDED COLLAGEN FIBRIL 9 12 3.165e-05 0.0003684
52 SARCOLEMMA 42 125 3.758e-05 0.0004221
53 KINESIN COMPLEX 23 55 5.007e-05 0.0005415
54 PERINUCLEAR REGION OF CYTOPLASM 158 642 4.939e-05 0.0005415
55 NUCLEAR ENVELOPE 109 416 5.21e-05 0.0005532
56 MICROBODY LUMEN 20 45 5.422e-05 0.0005654
57 ANCHORED COMPONENT OF MEMBRANE 48 152 6.631e-05 0.0006794
58 BASOLATERAL PLASMA MEMBRANE 62 211 7.193e-05 0.0007243
59 AMPA GLUTAMATE RECEPTOR COMPLEX 14 27 9.224e-05 0.000913
60 RECEPTOR COMPLEX 88 327 9.722e-05 0.0009463
61 MICROTUBULE CYTOSKELETON 244 1068 0.0001247 0.001193
62 VOLTAGE GATED SODIUM CHANNEL COMPLEX 9 14 0.000201 0.001893
63 ACTIN CYTOSKELETON 112 444 0.0002157 0.002
64 FILOPODIUM 32 94 0.0002295 0.002031
65 CHROMOSOMAL REGION 87 330 0.0002263 0.002031
66 HETEROTRIMERIC G PROTEIN COMPLEX 15 32 0.000224 0.002031
67 SODIUM CHANNEL COMPLEX 10 17 0.0002477 0.002159
68 DENDRITE MEMBRANE 11 20 0.0002701 0.00232
69 MICROTUBULE 102 405 0.000427 0.003614
70 PLASMA MEMBRANE RAFT 29 86 0.0005277 0.004402
71 CELL PROJECTION MEMBRANE 78 298 0.0005836 0.0048
72 T TUBULE 18 45 0.0006166 0.005001
73 SITE OF POLARIZED GROWTH 44 149 0.0006683 0.005346
74 MICROTUBULE ASSOCIATED COMPLEX 43 145 0.0006943 0.005479
75 DENDRITE CYTOPLASM 9 16 0.0008027 0.00625
76 CYTOSKELETAL PART 311 1436 0.0008258 0.006346
77 MYELIN SHEATH 48 168 0.0008777 0.006657
78 LEADING EDGE MEMBRANE 40 134 0.0009085 0.006802
79 SPINDLE 75 289 0.0009534 0.007048
80 NEURON PROJECTION MEMBRANE 15 36 0.001049 0.007655
81 REPLICATION FORK 22 62 0.001118 0.008058
82 EXTRINSIC COMPONENT OF CYTOPLASMIC SIDE OF PLASMA MEMBRANE 31 98 0.00117 0.008333
83 VOLTAGE GATED CALCIUM CHANNEL COMPLEX 16 40 0.001221 0.008588
84 PRESYNAPTIC MEMBRANE 20 55 0.001308 0.009093

Over-represented Pathway

NumPathwayPathviewOverlapSizeP ValueAdj. P Value
1 hsa04020_Calcium_signaling_pathway 76 387 0.2932 1
2 hsa04010_MAPK_signaling_pathway 63 387 0.8832 1
3 hsa04510_Focal_adhesion 59 387 0.9594 1
4 hsa04810_Regulation_of_actin_cytoskeleton 45 387 0.9999 1
5 hsa00010_Glycolysis_._Gluconeogenesis 15 387 1 1
6 hsa00020_Citrate_cycle_.TCA_cycle. 5 387 1 1
7 hsa00030_Pentose_phosphate_pathway 3 387 1 1
8 hsa00040_Pentose_and_glucuronate_interconversions 3 387 1 1
9 hsa00051_Fructose_and_mannose_metabolism 7 387 1 1
10 hsa00052_Galactose_metabolism 4 387 1 1
11 hsa00053_Ascorbate_and_aldarate_metabolism 3 387 1 1
12 hsa00061_Fatty_acid_biosynthesis 2 387 1 1
13 hsa00071_Fatty_acid_metabolism 21 387 1 1
14 hsa00072_Synthesis_and_degradation_of_ketone_bodies 4 387 1 1
15 hsa00100_Steroid_biosynthesis 2 387 1 1
16 hsa00120_Primary_bile_acid_biosynthesis 8 387 1 1
17 hsa00140_Steroid_hormone_biosynthesis 8 387 1 1
18 hsa00190_Oxidative_phosphorylation 19 387 1 1
19 hsa00230_Purine_metabolism 40 387 1 1
20 hsa00240_Pyrimidine_metabolism 20 387 1 1
21 hsa00250_Alanine._aspartate_and_glutamate_metabolism 10 387 1 1
22 hsa00260_Glycine._serine_and_threonine_metabolism 10 387 1 1
23 hsa00270_Cysteine_and_methionine_metabolism 8 387 1 1
24 hsa00280_Valine._leucine_and_isoleucine_degradation 18 387 1 1
25 hsa00310_Lysine_degradation 9 387 1 1
26 hsa00330_Arginine_and_proline_metabolism 15 387 1 1
27 hsa00340_Histidine_metabolism 7 387 1 1
28 hsa00350_Tyrosine_metabolism 11 387 1 1
29 hsa00360_Phenylalanine_metabolism 3 387 1 1
30 hsa00380_Tryptophan_metabolism 12 387 1 1
31 hsa00410_beta.Alanine_metabolism 10 387 1 1
32 hsa00430_Taurine_and_hypotaurine_metabolism 5 387 1 1
33 hsa00450_Selenocompound_metabolism 2 387 1 1
34 hsa00460_Cyanoamino_acid_metabolism 2 387 1 1
35 hsa00480_Glutathione_metabolism 13 387 1 1
36 hsa00500_Starch_and_sucrose_metabolism 8 387 1 1
37 hsa00510_N.Glycan_biosynthesis 5 387 1 1
38 hsa00512_Mucin_type_O.Glycan_biosynthesis 9 387 1 1
39 hsa00514_Other_types_of_O.glycan_biosynthesis 5 387 1 1
40 hsa00520_Amino_sugar_and_nucleotide_sugar_metabolism 12 387 1 1
41 hsa00531_Glycosaminoglycan_degradation 3 387 1 1
42 hsa00532_Glycosaminoglycan_biosynthesis_._chondroitin_sulfate 4 387 1 1
43 hsa00533_Glycosaminoglycan_biosynthesis_._keratan_sulfate 3 387 1 1
44 hsa00534_Glycosaminoglycan_biosynthesis_._heparan_sulfate 7 387 1 1
45 hsa00561_Glycerolipid_metabolism 10 387 1 1
46 hsa00562_Inositol_phosphate_metabolism 8 387 1 1
47 hsa00563_Glycosylphosphatidylinositol.GPI..anchor_biosynthesis 2 387 1 1
48 hsa00564_Glycerophospholipid_metabolism 14 387 1 1
49 hsa00565_Ether_lipid_metabolism 6 387 1 1
50 hsa00590_Arachidonic_acid_metabolism 15 387 1 1
51 hsa00591_Linoleic_acid_metabolism 6 387 1 1
52 hsa00592_alpha.Linolenic_acid_metabolism 5 387 1 1
53 hsa00600_Sphingolipid_metabolism 6 387 1 1
54 hsa00601_Glycosphingolipid_biosynthesis_._lacto_and_neolacto_series 6 387 1 1
55 hsa00603_Glycosphingolipid_biosynthesis_._globo_series 3 387 1 1
56 hsa00604_Glycosphingolipid_biosynthesis_._ganglio_series 7 387 1 1
57 hsa00620_Pyruvate_metabolism 11 387 1 1
58 hsa00630_Glyoxylate_and_dicarboxylate_metabolism 5 387 1 1
59 hsa00640_Propanoate_metabolism 15 387 1 1
60 hsa00650_Butanoate_metabolism 11 387 1 1
61 hsa00670_One_carbon_pool_by_folate 6 387 1 1
62 hsa00750_Vitamin_B6_metabolism 2 387 1 1
63 hsa00760_Nicotinate_and_nicotinamide_metabolism 7 387 1 1
64 hsa00770_Pantothenate_and_CoA_biosynthesis 3 387 1 1
65 hsa00830_Retinol_metabolism 13 387 1 1
66 hsa00860_Porphyrin_and_chlorophyll_metabolism 3 387 1 1
67 hsa00900_Terpenoid_backbone_biosynthesis 2 387 1 1
68 hsa00910_Nitrogen_metabolism 6 387 1 1
69 hsa00970_Aminoacyl.tRNA_biosynthesis 3 387 1 1
70 hsa00980_Metabolism_of_xenobiotics_by_cytochrome_P450 19 387 1 1
71 hsa00982_Drug_metabolism_._cytochrome_P450 22 387 1 1
72 hsa00983_Drug_metabolism_._other_enzymes 5 387 1 1
73 hsa01040_Biosynthesis_of_unsaturated_fatty_acids 9 387 1 1
74 hsa02010_ABC_transporters 14 387 1 1
75 hsa03008_Ribosome_biogenesis_in_eukaryotes 23 387 1 1
76 hsa03010_Ribosome 6 387 1 1
77 hsa03013_RNA_transport 25 387 1 1
78 hsa03015_mRNA_surveillance_pathway 11 387 1 1
79 hsa03018_RNA_degradation 7 387 1 1
80 hsa03020_RNA_polymerase 4 387 1 1
81 hsa03022_Basal_transcription_factors 3 387 1 1
82 hsa03030_DNA_replication 13 387 1 1
83 hsa03040_Spliceosome 7 387 1 1
84 hsa03320_PPAR_signaling_pathway 24 387 1 1
85 hsa03410_Base_excision_repair 5 387 1 1
86 hsa03420_Nucleotide_excision_repair 4 387 1 1
87 hsa03430_Mismatch_repair 6 387 1 1
88 hsa03440_Homologous_recombination 7 387 1 1
89 hsa03450_Non.homologous_end.joining 2 387 1 1
90 hsa04012_ErbB_signaling_pathway 20 387 1 1
91 hsa04062_Chemokine_signaling_pathway 42 387 1 1
92 hsa04070_Phosphatidylinositol_signaling_system 18 387 1 1
93 hsa04110_Cell_cycle 43 387 1 1
94 hsa04114_Oocyte_meiosis 32 387 1 1
95 hsa04115_p53_signaling_pathway 27 387 1 1
96 hsa04120_Ubiquitin_mediated_proteolysis 9 387 1 1
97 hsa04122_Sulfur_relay_system 3 387 1 1
98 hsa04130_SNARE_interactions_in_vesicular_transport 4 387 1 1
99 hsa04140_Regulation_of_autophagy 3 387 1 1
100 hsa04141_Protein_processing_in_endoplasmic_reticulum 18 387 1 1
101 hsa04142_Lysosome 15 387 1 1
102 hsa04144_Endocytosis 35 387 1 1
103 hsa04145_Phagosome 36 387 1 1
104 hsa04146_Peroxisome 23 387 1 1
105 hsa04150_mTOR_signaling_pathway 7 387 1 1
106 hsa04210_Apoptosis 13 387 1 1
107 hsa04260_Cardiac_muscle_contraction 20 387 1 1
108 hsa04270_Vascular_smooth_muscle_contraction 33 387 1 1
109 hsa04310_Wnt_signaling_pathway 35 387 1 1
110 hsa04320_Dorso.ventral_axis_formation 8 387 1 1
111 hsa04330_Notch_signaling_pathway 9 387 1 1
112 hsa04340_Hedgehog_signaling_pathway 16 387 1 1
113 hsa04350_TGF.beta_signaling_pathway 20 387 1 1
114 hsa04360_Axon_guidance 39 387 1 1
115 hsa04370_VEGF_signaling_pathway 10 387 1 1
116 hsa04380_Osteoclast_differentiation 28 387 1 1
117 hsa04512_ECM.receptor_interaction 39 387 1 1
118 hsa04514_Cell_adhesion_molecules_.CAMs. 44 387 1 1
119 hsa04520_Adherens_junction 14 387 1 1
120 hsa04530_Tight_junction 29 387 1 1
121 hsa04540_Gap_junction 23 387 1 1
122 hsa04610_Complement_and_coagulation_cascades 14 387 1 1
123 hsa04612_Antigen_processing_and_presentation 3 387 1 1
124 hsa04614_Renin.angiotensin_system 4 387 1 1
125 hsa04620_Toll.like_receptor_signaling_pathway 14 387 1 1
126 hsa04621_NOD.like_receptor_signaling_pathway 7 387 1 1
127 hsa04622_RIG.I.like_receptor_signaling_pathway 6 387 1 1
128 hsa04623_Cytosolic_DNA.sensing_pathway 6 387 1 1
129 hsa04630_Jak.STAT_signaling_pathway 21 387 1 1
130 hsa04640_Hematopoietic_cell_lineage 25 387 1 1
131 hsa04650_Natural_killer_cell_mediated_cytotoxicity 13 387 1 1
132 hsa04660_T_cell_receptor_signaling_pathway 10 387 1 1
133 hsa04662_B_cell_receptor_signaling_pathway 16 387 1 1
134 hsa04664_Fc_epsilon_RI_signaling_pathway 13 387 1 1
135 hsa04666_Fc_gamma_R.mediated_phagocytosis 23 387 1 1
136 hsa04670_Leukocyte_transendothelial_migration 27 387 1 1
137 hsa04672_Intestinal_immune_network_for_IgA_production 4 387 1 1
138 hsa04710_Circadian_rhythm_._mammal 5 387 1 1
139 hsa04720_Long.term_potentiation 20 387 1 1
140 hsa04722_Neurotrophin_signaling_pathway 23 387 1 1
141 hsa04730_Long.term_depression 20 387 1 1
142 hsa04740_Olfactory_transduction 11 388 1 1
143 hsa04742_Taste_transduction 8 387 1 1
144 hsa04744_Phototransduction 5 387 1 1
145 hsa04910_Insulin_signaling_pathway 25 387 1 1
146 hsa04912_GnRH_signaling_pathway 23 387 1 1
147 hsa04914_Progesterone.mediated_oocyte_maturation 23 387 1 1
148 hsa04916_Melanogenesis 30 387 1 1
149 hsa04920_Adipocytokine_signaling_pathway 19 387 1 1
150 hsa04960_Aldosterone.regulated_sodium_reabsorption 12 387 1 1
151 hsa04962_Vasopressin.regulated_water_reabsorption 11 387 1 1
152 hsa04964_Proximal_tubule_bicarbonate_reclamation 5 387 1 1
153 hsa04966_Collecting_duct_acid_secretion 8 387 1 1
154 hsa04970_Salivary_secretion 30 387 1 1
155 hsa04971_Gastric_acid_secretion 30 387 1 1
156 hsa04972_Pancreatic_secretion 26 387 1 1
157 hsa04973_Carbohydrate_digestion_and_absorption 9 387 1 1
158 hsa04974_Protein_digestion_and_absorption 26 387 1 1
159 hsa04975_Fat_digestion_and_absorption 8 387 1 1
160 hsa04976_Bile_secretion 22 387 1 1
161 hsa04977_Vitamin_digestion_and_absorption 7 387 1 1

Quest ID: 4cd58ea48361456e65500b63a3dd0c92