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This regulatory network was inferred from the input dataset. The miRNAs and mRNAs are presented as round and rectangle nodes respectively. The numerical value popped up upon mouse over the gene node is the log2 transformed fold-change of the gene expression between the two groups. All of the nodes are clickable, and the detailed information of the miRNAs/mRNAs and related cancer pathway will be displayed in another window. The edges between nodes are supported by both interactions (predicted or experimentally verified) and correlations learnt from cancer dataset. The numerical value popped up upon mouse over the edge is the correlation beat value (effect size) between the two nodes. The experimental evidences of the edges reported in previous cancer studies are highlighted by red/orange color. All of these information can be accessed by the "mouse-over" action. This network shows a full map of the miRNA-mRNA regulation of the input gene list(s), and the hub miRNAs (with the high network degree/betweenness centrality) would be the potential cancer drivers or tumor suppressors. The full result table can be accessed in the "Regulations" tab.

"miRNACancerMAP" is also a network visualization tool for users to draw their regulatory network by personal customization. Users can set the complexity of the network by limiting the number of nodes or edges. And the color of the nodes can be defined by different categories of the mRNAs and miRNAs, such as Gene-Ontology, pathway, and expression status. Users can also select to use network degree or network betweenness centrality to define the node size. And edges can be black or colored by the correlation. Purple edge means negative correlation (mostly found between miRNA and mRNA), and blue edge means positive correlation (found in PPI or miRNA-miRNA sponge effect). We can also add the protein-protein interactions (PPI) into the network. This result will show the cluster of genes regulated by some specific miRNAs. Additionally, miRNA-miRNA edges can be added by the "miRNA sponge" button, presenting some clusters of miRNAs that have the interactions via sponge effect.

miRNA-gene regulations

(Download full result)

Num microRNA           Gene miRNA log2FC miRNA pvalue Gene log2FC Gene pvalue Interaction Correlation beta Correlation P-value PMID Reported in cancer studies
1 hsa-miR-155-5p ACADSB 0.01 0.95651 -2.11 0 mirMAP -0.27 0 NA
2 hsa-miR-155-5p ACSL6 0.01 0.95651 0.39 0.26458 mirMAP -0.39 0 NA
3 hsa-miR-155-5p ADH5 0.01 0.95651 -0.53 0 miRNAWalker2 validate -0.14 0 NA
4 hsa-miR-155-5p AGL 0.01 0.95651 -1.74 0 miRNAWalker2 validate -0.16 0.0001 NA
5 hsa-miR-155-5p ALDH3A2 0.01 0.95651 -0.55 0.00022 miRNAWalker2 validate; mirMAP -0.26 0 NA
6 hsa-miR-155-5p ALDH5A1 0.01 0.95651 -1.1 0 miRNAWalker2 validate -0.32 0 NA
7 hsa-miR-155-5p ALDH9A1 0.01 0.95651 -1.02 0 miRNAWalker2 validate -0.19 0 NA
8 hsa-miR-155-5p ANPEP 0.01 0.95651 -0.91 0 miRNAWalker2 validate -0.16 0.00051 NA
9 hsa-miR-155-5p AQP4 0.01 0.95651 -2.6 0 mirMAP -0.2 0.04646 NA
10 hsa-miR-155-5p AR 0.01 0.95651 -2.66 0 mirMAP -0.47 0 NA
11 hsa-miR-155-5p ARHGAP32 0.01 0.95651 -0.2 0.09921 mirMAP -0.19 0 NA
12 hsa-miR-155-5p ARHGAP5 0.01 0.95651 -0.39 8.0E-5 mirMAP -0.11 1.0E-5 NA
13 hsa-miR-155-5p ARNTL 0.01 0.95651 -0.35 0.02331 miRNATAP -0.11 0.00305 NA
14 hsa-miR-155-5p ATL2 0.01 0.95651 -0.1 0.23951 miRNAWalker2 validate -0.13 0 NA
15 hsa-miR-155-5p ATPAF1 0.01 0.95651 -0.62 0 miRNAWalker2 validate -0.11 0 NA
16 hsa-miR-155-5p BRPF3 0.01 0.95651 0.35 0.00299 miRNAWalker2 validate; miRTarBase -0.15 0 NA
17 hsa-miR-155-5p BRWD1 0.01 0.95651 -0.47 0 mirMAP -0.11 0 NA
18 hsa-miR-155-5p C3orf18 0.01 0.95651 0.57 0.00014 miRNATAP -0.12 0.00138 NA
19 hsa-miR-15a-5p CAB39 0.35 0.00077 -0.15 0.00963 miRNATAP -0.11 8.0E-5 NA
20 hsa-miR-16-1-3p CAB39 0.39 0.00112 -0.15 0.00963 MirTarget -0.12 0 NA
21 hsa-miR-193a-3p CAB39 -0.12 0.30939 -0.15 0.00963 MirTarget; miRanda -0.12 0 NA
22 hsa-miR-155-5p CAT 0.01 0.95651 -1.65 0 miRNAWalker2 validate -0.25 0 NA
23 hsa-miR-155-5p CBR4 0.01 0.95651 -1.38 0 miRNAWalker2 validate -0.18 0 NA
24 hsa-miR-155-5p CD36 0.01 0.95651 -0.22 0.39034 miRNAWalker2 validate -0.13 0.038 NA
25 hsa-miR-155-5p CDC42EP4 0.01 0.95651 0.25 0.00876 MirTarget -0.12 0 NA
26 hsa-miR-155-5p CDK5RAP3 0.01 0.95651 0.71 0 miRNAWalker2 validate -0.11 0 NA
27 hsa-miR-421 CEBPB 0.94 0 -0.56 4.0E-5 miRNAWalker2 validate; PITA; miRanda -0.23 0 NA
28 hsa-miR-423-5p CEBPB 0.7 0 -0.56 4.0E-5 miRNAWalker2 validate; miRNATAP -0.35 0 NA
29 hsa-miR-155-5p CFL2 0.01 0.95651 -1.18 0 miRNAWalker2 validate -0.15 0 NA
30 hsa-miR-155-5p CLDN1 0.01 0.95651 -0.93 0 miRNAWalker2 validate; miRTarBase -0.13 0.0042 23523916; 23588589 MicroRNA 155 is a novel suppressor of ovarian cancer initiating cells that targets CLDN1; Here we show that the downregulation of miR-155 in OCICs correlates with CLDN1 overexpression and the suppression of OCIC invasion; Luciferase assays indicate that miR-155 targets CLDN1 mRNA on the 3' UTR; Thus overexpression of miR-155 may prevent tumorigenesis in human ovarian cancer through downregulation of CLDN1;Upregulation of microRNA 155 promotes the migration and invasion of colorectal cancer cells through the regulation of claudin 1 expression; Furthermore the overexpression of miR-155 upregulated claudin-1 expression; Thus our data suggest that miR-155 plays an important role in promoting CRC cell migration and invasion at least in part through the regulation of claudin-1 expression and controlling metastasis in CRC
31 hsa-miR-155-5p CNNM3 0.01 0.95651 -0.24 0.00905 miRNAWalker2 validate -0.2 0 NA
32 hsa-miR-155-5p COBLL1 0.01 0.95651 -1.47 0 mirMAP -0.29 0 NA
33 hsa-miR-155-5p CPEB4 0.01 0.95651 -1.06 0 mirMAP -0.17 0 NA
34 hsa-miR-155-5p CPT1A 0.01 0.95651 -0.73 0 miRNAWalker2 validate -0.17 0 NA
35 hsa-miR-155-5p CRAT 0.01 0.95651 -0.76 0 miRNAWalker2 validate -0.15 0 NA
36 hsa-miR-155-5p CTAGE5 0.01 0.95651 -0.71 0 miRNAWalker2 validate -0.19 0 NA
37 hsa-miR-155-5p CUTA 0.01 0.95651 0.57 0 miRNAWalker2 validate -0.12 7.0E-5 NA
38 hsa-miR-155-5p CUX1 0.01 0.95651 -0.19 0.03981 miRNAWalker2 validate -0.1 1.0E-5 NA
39 hsa-miR-155-5p CYP51A1 0.01 0.95651 -0.01 0.94414 miRNAWalker2 validate -0.16 0 NA
40 hsa-miR-155-5p DAG1 0.01 0.95651 0.14 0.11396 miRNAWalker2 validate -0.1 0 NA
41 hsa-miR-155-5p DCUN1D4 0.01 0.95651 -0.24 0.00352 miRNATAP -0.13 0 NA
42 hsa-miR-155-5p DDI2 0.01 0.95651 -1.53 0 mirMAP -0.24 0.00296 NA
43 hsa-miR-155-5p DHCR24 0.01 0.95651 -0.3 0.02121 miRNAWalker2 validate -0.14 1.0E-5 NA
44 hsa-miR-155-5p DHX40 0.01 0.95651 -0.12 0.19544 miRNAWalker2 validate; miRTarBase; MirTarget -0.13 0 NA
45 hsa-miR-155-5p DMD 0.01 0.95651 -1.66 0 miRNAWalker2 validate -0.17 0.00054 NA
46 hsa-miR-155-5p DNAJC19 0.01 0.95651 -0.3 0.00148 miRNAWalker2 validate -0.17 0 NA
47 hsa-miR-155-5p EBF3 0.01 0.95651 1.74 0 mirMAP -0.14 0.01968 NA
48 hsa-miR-155-5p EGFR 0.01 0.95651 -1.02 0 miRNAWalker2 validate; MirTarget -0.13 0.01158 NA
49 hsa-miR-155-5p ELL2 0.01 0.95651 -0.77 0 miRNATAP -0.12 0.00161 NA
50 hsa-miR-155-5p ETNK2 0.01 0.95651 -1.42 0 miRNATAP -0.37 0 NA
51 hsa-miR-10b-3p ETS1 2.77 0 -0.89 0 mirMAP -0.11 2.0E-5 NA
52 hsa-miR-1180-3p ETS1 1.14 0 -0.89 0 MirTarget -0.29 0 NA
53 hsa-miR-130b-5p ETS1 0.17 0.33761 -0.89 0 MirTarget -0.12 0.00351 NA
54 hsa-miR-148b-5p ETS1 0.3 0.02557 -0.89 0 MirTarget -0.14 0.00795 NA
55 hsa-miR-16-1-3p ETS1 0.39 0.00112 -0.89 0 MirTarget -0.14 0.01763 NA
56 hsa-miR-186-5p ETS1 -0.06 0.53529 -0.89 0 mirMAP -0.15 0.04115 NA
57 hsa-miR-193a-3p ETS1 -0.12 0.30939 -0.89 0 miRanda; miRNATAP -0.21 0.00092 NA
58 hsa-miR-221-3p ETS1 1.12 0 -0.89 0 miRTarBase; miRNATAP -0.16 0.00028 21711453 To close the loop we demonstrate ETS-1 as a direct target of miR-222 but not miR-221 showing the novel option of their uncoupled functions
59 hsa-miR-222-3p ETS1 1.09 0 -0.89 0 miRNAWalker2 validate; miRTarBase; miRNATAP -0.11 0.00861 21711453 Constitutive activation of the ETS 1 miR 222 circuitry in metastatic melanoma; We demonstrate that the proto-oncogene ETS-1 involved in the pathogenesis of cancers of different origin is a transcriptional regulator of miR-222 by direct binding to its promoter region; Differently from 293FT cells or early stage melanomas where unphosphorylated ETS-1 represses miR-222 transcription in metastatic melanoma the constitutively Thr-38 phosphorylated fraction of ETS-1 induces miR-222; To close the loop we demonstrate ETS-1 as a direct target of miR-222 but not miR-221 showing the novel option of their uncoupled functions
60 hsa-miR-30d-3p ETS1 -0.12 0.32955 -0.89 0 mirMAP -0.12 0.03442 NA
61 hsa-miR-362-3p ETS1 0.81 0 -0.89 0 miRanda -0.18 0.00046 NA
62 hsa-miR-365a-3p ETS1 0.16 0.15325 -0.89 0 MirTarget -0.27 2.0E-5 NA
63 hsa-miR-421 ETS1 0.94 0 -0.89 0 miRanda; mirMAP; miRNATAP -0.2 0 NA
64 hsa-miR-455-5p ETS1 -0.27 0.05813 -0.89 0 MirTarget; PITA; miRanda; miRNATAP -0.23 0 NA
65 hsa-miR-501-5p ETS1 1.15 0 -0.89 0 mirMAP -0.1 0.00735 NA
66 hsa-miR-502-5p ETS1 0.89 0 -0.89 0 miRNATAP -0.11 0.00448 NA
67 hsa-miR-532-3p ETS1 0.3 0.01463 -0.89 0 MirTarget; PITA; miRNATAP -0.29 0 NA
68 hsa-miR-590-5p ETS1 -0.1 0.31003 -0.89 0 miRanda -0.36 0 NA
69 hsa-miR-660-5p ETS1 0.99 0 -0.89 0 MirTarget -0.25 0 NA
70 hsa-miR-769-5p ETS1 0.22 0.03334 -0.89 0 miRNATAP -0.21 0.00233 NA
71 hsa-miR-940 ETS1 0.45 0.01771 -0.89 0 MirTarget; miRNATAP -0.15 7.0E-5 NA
72 hsa-miR-155-5p F5 0.01 0.95651 -0.33 0.13065 miRNAWalker2 validate -0.31 0 NA
73 hsa-miR-155-5p FAM114A1 0.01 0.95651 -0.54 0.00066 mirMAP -0.11 0.00618 NA
74 hsa-miR-155-5p FAM177A1 0.01 0.95651 -0.35 0.00024 miRNAWalker2 validate -0.11 0 NA
75 hsa-miR-155-5p FAM8A1 0.01 0.95651 -0.45 0.0012 mirMAP -0.25 0 NA
76 hsa-miR-155-5p FGD4 0.01 0.95651 -1.16 0 mirMAP -0.22 0 NA
77 hsa-miR-155-5p FKBP5 0.01 0.95651 -0.23 0.1942 mirMAP -0.14 0.00111 NA
78 hsa-miR-155-5p FZD5 0.01 0.95651 -0.37 0.00194 miRNATAP -0.11 0.00019 NA
79 hsa-miR-155-5p GABARAPL1 0.01 0.95651 -1.46 0 miRNAWalker2 validate -0.25 0 NA
80 hsa-miR-155-5p GATM 0.01 0.95651 -1.68 0 miRNAWalker2 validate -0.25 3.0E-5 NA
81 hsa-miR-155-5p GCLC 0.01 0.95651 -0.76 0 miRNAWalker2 validate -0.2 0 NA
82 hsa-miR-155-5p GFRA1 0.01 0.95651 -2.55 0 mirMAP -0.31 0.00583 NA
83 hsa-miR-155-5p GLUL 0.01 0.95651 0.44 0.12619 MirTarget -0.34 0 NA
84 hsa-miR-155-5p GPAM 0.01 0.95651 -0.47 0.0638 miRNAWalker2 validate -0.33 0 NA
85 hsa-miR-155-5p GPT2 0.01 0.95651 -1.48 0 miRNAWalker2 validate -0.29 0 NA
86 hsa-miR-155-5p GTPBP10 0.01 0.95651 -0.21 0.01214 mirMAP -0.11 0 NA
87 hsa-miR-155-5p HBP1 0.01 0.95651 -0.36 2.0E-5 miRNAWalker2 validate; MirTarget; miRNATAP -0.14 0 25666090 miR 155 promotes the growth of osteosarcoma in a HBP1 dependent mechanism; HMG-box transcription factor 1 HBP1 a strong Wnt pathway suppressor was found to be a target of miR-155; Restoration of HBP1 abolished the effect of miR-155 on OS cells
88 hsa-miR-107 HIF1A 0.24 0.01708 -0.37 0.0111 miRNAWalker2 validate; miRTarBase; miRanda -0.44 0 NA
89 hsa-miR-17-5p HIF1A 0.7 2.0E-5 -0.37 0.0111 miRTarBase; MirTarget; TargetScan -0.21 0 NA
90 hsa-miR-20a-5p HIF1A 0.85 0 -0.37 0.0111 miRNAWalker2 validate; miRTarBase; MirTarget -0.25 0 22901144 Correlation analysis showed that the key miRNAs miR-20a and miR-20b negatively correlated with the target proteins VEGF-A and HIF-1alpha
91 hsa-miR-33a-5p HIF1A -0.77 1.0E-5 -0.37 0.0111 miRNAWalker2 validate -0.11 0.0073 NA
92 hsa-miR-616-5p HIF1A 0.15 0.40284 -0.37 0.0111 MirTarget -0.12 0.00144 NA
93 hsa-miR-660-5p HIF1A 0.99 0 -0.37 0.0111 MirTarget -0.25 0 NA
94 hsa-miR-93-5p HIF1A 1.4 0 -0.37 0.0111 MirTarget -0.17 0.00043 NA
95 hsa-miR-155-5p HSD17B7 0.01 0.95651 0.54 0.00022 miRNAWalker2 validate -0.12 0.00063 NA
96 hsa-miR-155-5p IL6R 0.01 0.95651 -0.2 0.38255 MirTarget -0.28 0 NA
97 hsa-miR-616-5p ITK 0.15 0.40284 -0.97 6.0E-5 mirMAP -0.2 0.00333 NA
98 hsa-miR-139-5p JARID2 -2.11 0 0.39 3.0E-5 miRanda -0.12 0 NA
99 hsa-miR-152-3p JARID2 -0.96 0 0.39 3.0E-5 MirTarget -0.1 0.00039 NA
100 hsa-miR-195-5p JARID2 -1.86 0 0.39 3.0E-5 MirTarget; miRNATAP -0.16 0 NA
101 hsa-miR-22-3p JARID2 -0.63 0 0.39 3.0E-5 miRNATAP -0.36 0 NA
102 hsa-miR-29a-3p JARID2 -0.86 0 0.39 3.0E-5 MirTarget; miRNATAP -0.21 0 NA
103 hsa-miR-29b-3p JARID2 -0.35 0.01214 0.39 3.0E-5 MirTarget; miRNATAP -0.15 1.0E-5 NA
104 hsa-miR-29c-3p JARID2 -1.44 0 0.39 3.0E-5 MirTarget; miRNATAP -0.19 0 NA
105 hsa-miR-30a-5p JARID2 -0.63 0.00011 0.39 3.0E-5 MirTarget; miRNATAP -0.1 0.00031 NA
106 hsa-miR-497-5p JARID2 -1.41 0 0.39 3.0E-5 MirTarget; miRNATAP -0.2 0 NA
107 hsa-miR-155-5p JUP 0.01 0.95651 -0.1 0.30916 miRNAWalker2 validate -0.15 0 NA
108 hsa-miR-155-5p KANK2 0.01 0.95651 0.2 0.08382 miRNAWalker2 validate -0.12 1.0E-5 NA
109 hsa-miR-155-5p KCND3 0.01 0.95651 -3.74 0 mirMAP -0.24 0.02918 NA
110 hsa-miR-140-3p KRAS 0.55 0 -0.34 0.00044 MirTarget -0.25 1.0E-5 NA
111 hsa-miR-16-1-3p KRAS 0.39 0.00112 -0.34 0.00044 mirMAP -0.11 0.0033 NA
112 hsa-miR-193a-3p KRAS -0.12 0.30939 -0.34 0.00044 MirTarget; miRanda; miRNATAP -0.13 0.00171 NA
113 hsa-miR-193b-3p KRAS -0.17 0.27202 -0.34 0.00044 miRNAWalker2 validate; MirTarget; miRNATAP -0.12 0.0001 25905463 Deregulation of the MiR 193b KRAS Axis Contributes to Impaired Cell Growth in Pancreatic Cancer; Mechanistically KRAS was verified as a direct effector of miR-193b through which the AKT and ERK pathways were modulated and cell growth of PDAC cells was suppressed; Taken together our findings indicate that miR-193b-mediated deregulation of the KRAS axis is involved in pancreatic carcinogenesis and suggest that miR-193b could be a potentially effective target for PDAC therapy
114 hsa-miR-30d-3p KRAS -0.12 0.32955 -0.34 0.00044 MirTarget; miRNATAP -0.13 0.00051 NA
115 hsa-miR-532-5p KRAS 1.03 0 -0.34 0.00044 MirTarget; PITA; miRNATAP -0.14 0.0001 NA
116 hsa-miR-155-5p KRCC1 0.01 0.95651 -0.5 0 miRNAWalker2 validate -0.15 0 NA
117 hsa-miR-155-5p L2HGDH 0.01 0.95651 -0.86 0 miRNAWalker2 validate -0.2 0 NA
118 hsa-miR-155-5p LCOR 0.01 0.95651 -0.83 0.00038 miRNATAP -0.12 0.04063 NA
119 hsa-miR-155-5p LEPROT 0.01 0.95651 -0.77 0.00143 mirMAP -0.15 0.01148 NA
120 hsa-miR-155-5p LIMD1 0.01 0.95651 0.24 0.01904 mirMAP -0.11 3.0E-5 NA
121 hsa-miR-155-5p LNX2 0.01 0.95651 -0.99 0 miRNAWalker2 validate -0.11 0.00031 NA
122 hsa-miR-155-5p LONP2 0.01 0.95651 -1.16 0 miRNAWalker2 validate -0.17 0 NA
123 hsa-miR-106b-5p LRP1B 0.65 0 -1.67 0.0001 MirTarget -0.4 0.03214 NA
124 hsa-miR-107 LRP1B 0.24 0.01708 -1.67 0.0001 MirTarget; PITA; miRanda; miRNATAP -0.59 0.00488 NA
125 hsa-miR-196b-5p LRP1B 0.98 0.00842 -1.67 0.0001 miRNATAP -0.12 0.02915 NA
126 hsa-miR-200b-3p LRP1B -1.29 0.00027 -1.67 0.0001 MirTarget; TargetScan -0.14 0.01404 NA
127 hsa-miR-335-3p LRP1B -0.28 0.10663 -1.67 0.0001 MirTarget; mirMAP -0.25 0.04012 NA
128 hsa-miR-429 LRP1B -1.4 7.0E-5 -1.67 0.0001 MirTarget; PITA; miRanda; miRNATAP -0.21 0.00033 NA
129 hsa-miR-454-3p LRP1B 0.67 0 -1.67 0.0001 miRNATAP -0.46 0.00174 NA
130 hsa-miR-455-5p LRP1B -0.27 0.05813 -1.67 0.0001 miRanda -0.57 0.00012 NA
131 hsa-miR-155-5p MBLAC2 0.01 0.95651 -0.65 0 miRNAWalker2 validate -0.21 0 NA
132 hsa-miR-155-5p METTL7A 0.01 0.95651 -1.15 0 miRNAWalker2 validate -0.29 0 NA
133 hsa-miR-155-5p MFAP3L 0.01 0.95651 -3 0 mirMAP -0.21 0.017 NA
134 hsa-miR-155-5p MGST2 0.01 0.95651 -0.57 1.0E-5 miRNAWalker2 validate -0.14 1.0E-5 NA
135 hsa-miR-155-5p MKLN1 0.01 0.95651 -0.43 0 mirMAP -0.12 0 NA
136 hsa-miR-155-5p MORC3 0.01 0.95651 -0.49 1.0E-5 miRNAWalker2 validate; MirTarget -0.13 0 NA
137 hsa-miR-155-5p MPP5 0.01 0.95651 -0.29 0.00156 miRNAWalker2 validate; MirTarget -0.11 0 NA
138 hsa-miR-155-5p MRPS27 0.01 0.95651 0.08 0.30017 miRNAWalker2 validate -0.1 0 NA
139 hsa-miR-155-5p MRS2 0.01 0.95651 0.38 0 miRNAWalker2 validate -0.1 0 NA
140 hsa-miR-155-5p MUT 0.01 0.95651 -1.59 0 miRNAWalker2 validate -0.23 0 23715647 The regulation of Mut L homologue 1 MLH1 expression by microRNA miR-155 and its prognostic significance in pancreatic cancer PC remain to be elucidated
141 hsa-miR-155-5p NDFIP1 0.01 0.95651 -0.23 0.00532 MirTarget; miRNATAP -0.11 0 NA
142 hsa-miR-155-5p NFIA 0.01 0.95651 -0.92 0 miRNATAP -0.21 0 NA
143 hsa-miR-155-5p NFIB 0.01 0.95651 -0.47 0.00023 miRNATAP -0.13 2.0E-5 NA
144 hsa-miR-155-5p NGEF 0.01 0.95651 0.06 0.7062 miRNATAP -0.22 0 NA
145 hsa-miR-155-5p NNT 0.01 0.95651 -1.01 0 mirMAP -0.24 0 NA
146 hsa-miR-155-5p NR3C1 0.01 0.95651 -0.43 0 miRNAWalker2 validate -0.13 0 NA
147 hsa-miR-155-5p OXNAD1 0.01 0.95651 -0.65 0 miRNAWalker2 validate -0.11 3.0E-5 NA
148 hsa-miR-155-5p PACSIN3 0.01 0.95651 -0.56 0.00343 miRNAWalker2 validate -0.23 0 NA
149 hsa-miR-155-5p PANK1 0.01 0.95651 -1.79 0 miRNATAP -0.28 0 NA
150 hsa-miR-155-5p PCCB 0.01 0.95651 -0.68 0 miRNAWalker2 validate -0.12 2.0E-5 NA

Over-represented Gene Ontology Biological Process

NumGOOverlapSizeP ValueAdj. P Value
1 CARBOXYLIC ACID CATABOLIC PROCESS 11 205 1.584e-06 0.001189
2 SMALL MOLECULE METABOLIC PROCESS 35 1767 2.044e-06 0.001189
3 MONOCARBOXYLIC ACID METABOLIC PROCESS 17 503 1.571e-06 0.001189
4 ORGANIC ACID METABOLIC PROCESS 24 953 2.041e-06 0.001189
5 ORGANIC ACID CATABOLIC PROCESS 11 205 1.584e-06 0.001189
6 FATTY ACID METABOLIC PROCESS 14 296 2.701e-07 0.001189
7 LIPID METABOLIC PROCESS 27 1158 1.902e-06 0.001189
8 MONOCARBOXYLIC ACID CATABOLIC PROCESS 8 96 1.696e-06 0.001189
9 FATTY ACID CATABOLIC PROCESS 7 73 2.994e-06 0.001548
10 GLAND DEVELOPMENT 14 395 7.998e-06 0.003666
11 REGULATION OF FATTY ACID BETA OXIDATION 4 16 8.666e-06 0.003666
12 PROTEIN HOMOOLIGOMERIZATION 11 248 9.846e-06 0.003818
13 POST EMBRYONIC DEVELOPMENT 7 89 1.129e-05 0.004041
14 ORGANIC HYDROXY COMPOUND METABOLIC PROCESS 15 482 1.764e-05 0.005863
15 PROTEIN OLIGOMERIZATION 14 434 2.289e-05 0.007101
16 SMALL MOLECULE CATABOLIC PROCESS 12 328 2.656e-05 0.007725
17 OXIDATION REDUCTION PROCESS 21 898 2.837e-05 0.007765
18 PROTEIN COMPLEX BIOGENESIS 24 1132 3.585e-05 0.008401
19 CELLULAR LIPID METABOLIC PROCESS 21 913 3.611e-05 0.008401
20 PROTEIN COMPLEX ASSEMBLY 24 1132 3.585e-05 0.008401
21 RESPONSE TO ENDOGENOUS STIMULUS 28 1450 4.032e-05 0.008528
22 PROTEIN COMPLEX SUBUNIT ORGANIZATION 29 1527 3.897e-05 0.008528
23 REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 32 1784 4.456e-05 0.009014
24 CELLULAR LIPID CATABOLIC PROCESS 8 151 4.77e-05 0.009248
25 RESPONSE TO AMINO ACID 7 112 5.036e-05 0.009373
NumGOOverlapSizeP ValueAdj. P Value
1 ENZYME BINDING 35 1737 1.383e-06 0.001285
2 RNA POLYMERASE II TRANSCRIPTION FACTOR ACTIVITY SEQUENCE SPECIFIC DNA BINDING 18 629 7.818e-06 0.002758
3 DOUBLE STRANDED DNA BINDING 20 764 8.907e-06 0.002758
4 ALDEHYDE DEHYDROGENASE NAD ACTIVITY 4 19 1.809e-05 0.002801
5 UBIQUITIN LIKE PROTEIN LIGASE BINDING 11 264 1.766e-05 0.002801
6 COFACTOR BINDING 11 263 1.705e-05 0.002801
7 TRANSCRIPTION FACTOR ACTIVITY RNA POLYMERASE II CORE PROMOTER PROXIMAL REGION SEQUENCE SPECIFIC BINDING 12 328 2.656e-05 0.003526
8 MOLECULAR FUNCTION REGULATOR 27 1353 3.205e-05 0.003722
9 CAMP BINDING 4 23 4.024e-05 0.004154
NumGOOverlapSizeP ValueAdj. P Value
1 MITOCHONDRION 31 1633 2.032e-05 0.005933
2 ENDOPLASMIC RETICULUM 31 1631 1.984e-05 0.005933

Over-represented Pathway

NumPathwayPathviewOverlapSizeP ValueAdj. P Value
1 FoxO_signaling_pathway_hsa04068 5 132 0.005572 0.1459
2 Peroxisome_hsa04146 4 83 0.005613 0.1459
3 Mitophagy_animal_hsa04137 3 65 0.01822 0.2529
4 Adherens_junction_hsa04520 3 72 0.02382 0.2529
5 Signaling_pathways_regulating_pluripotency_of_stem_cells_hsa04550 4 139 0.03158 0.2529
6 Gap_junction_hsa04540 3 88 0.03974 0.2529
7 mTOR_signaling_pathway_hsa04150 4 151 0.04085 0.2529
8 Hippo_signaling_pathway_hsa04390 4 154 0.04338 0.2529
9 Ferroptosis_hsa04216 2 40 0.04586 0.2529
10 Jak_STAT_signaling_pathway_hsa04630 4 162 0.05056 0.2529
11 HIF_1_signaling_pathway_hsa04066 3 100 0.05444 0.2529
12 Tight_junction_hsa04530 4 170 0.05836 0.2529
13 AMPK_signaling_pathway_hsa04152 3 121 0.08541 0.3274
14 Oocyte_meiosis_hsa04114 3 124 0.09034 0.3274
15 Autophagy_animal_hsa04140 3 128 0.09709 0.3274
16 Rap1_signaling_pathway_hsa04015 4 206 0.1007 0.3274
17 Apelin_signaling_pathway_hsa04371 3 137 0.113 0.3456
18 Phospholipase_D_signaling_pathway_hsa04072 3 146 0.1298 0.375
19 ECM_receptor_interaction_hsa04512 2 82 0.1555 0.4074
20 Cellular_senescence_hsa04218 3 160 0.1576 0.4074
21 ErbB_signaling_pathway_hsa04012 2 85 0.1645 0.4074
22 MAPK_signaling_pathway_hsa04010 4 295 0.246 0.5329
23 Regulation_of_actin_cytoskeleton_hsa04810 3 208 0.263 0.5351
24 Sphingolipid_signaling_pathway_hsa04071 2 118 0.2675 0.5351
25 Ras_signaling_pathway_hsa04014 3 232 0.3188 0.614
26 Endocytosis_hsa04144 3 244 0.3469 0.6374
27 Wnt_signaling_pathway_hsa04310 2 146 0.3555 0.6374
28 cAMP_signaling_pathway_hsa04024 2 198 0.5065 0.8109
29 Focal_adhesion_hsa04510 2 199 0.5092 0.8109
30 PI3K_Akt_signaling_pathway_hsa04151 3 352 0.5819 0.89
31 Cytokine_cytokine_receptor_interaction_hsa04060 2 270 0.6744 0.9478

lncRNA-mediated sponge

(Download full result)

Num lncRNA miRNAs           miRNAs count     Gene Sponge regulatory network lncRNA log2FC lncRNA pvalue Gene log2FC Gene pvalue lncRNA-gene Pearson correlation
1 HCG11 hsa-miR-10b-3p;hsa-miR-1180-3p;hsa-miR-130b-5p;hsa-miR-148b-5p;hsa-miR-16-1-3p;hsa-miR-186-5p;hsa-miR-193a-3p;hsa-miR-221-3p;hsa-miR-362-3p;hsa-miR-421;hsa-miR-455-5p;hsa-miR-532-3p 12 ETS1 Sponge network -0.781 0 -0.888 0 0.78
2 RP11-166D19.1 hsa-miR-1180-3p;hsa-miR-148b-5p;hsa-miR-16-1-3p;hsa-miR-186-5p;hsa-miR-193a-3p;hsa-miR-222-3p;hsa-miR-421;hsa-miR-532-3p;hsa-miR-590-5p;hsa-miR-940 10 ETS1 Sponge network -0.244 0.28835 -0.888 0 0.417
3

MAGI2-AS3

 hsa-miR-10b-3p;hsa-miR-1180-3p;hsa-miR-193a-3p;hsa-miR-221-3p;hsa-miR-222-3p;hsa-miR-362-3p;hsa-miR-421;hsa-miR-455-5p;hsa-miR-501-5p;hsa-miR-532-3p;hsa-miR-660-5p;hsa-miR-769-5p;hsa-miR-940 13 ETS1 Sponge network -1.801 0 -0.888 0 0.413
4 DHRS4-AS1 hsa-miR-1180-3p;hsa-miR-148b-5p;hsa-miR-221-3p;hsa-miR-222-3p;hsa-miR-30d-3p;hsa-miR-421;hsa-miR-501-5p;hsa-miR-502-5p;hsa-miR-660-5p;hsa-miR-769-5p 10 ETS1 Sponge network -0.646 0.01829 -0.888 0 0.384
5

MAGI2-AS3

 hsa-miR-17-5p;hsa-miR-18a-5p;hsa-miR-19a-3p;hsa-miR-19b-3p;hsa-miR-21-5p;hsa-miR-30d-5p;hsa-miR-324-5p;hsa-miR-362-3p;hsa-miR-362-5p;hsa-miR-501-5p;hsa-miR-589-3p 11 SATB1 Sponge network -1.801 0 -1.662 0 0.332
6 RP11-25H12.1 hsa-miR-125b-2-3p;hsa-miR-139-5p;hsa-miR-144-3p;hsa-miR-195-5p;hsa-miR-199a-3p;hsa-miR-199b-3p;hsa-miR-22-5p;hsa-miR-30a-3p;hsa-miR-30e-3p;hsa-miR-3607-3p;hsa-miR-424-5p;hsa-miR-497-5p 12 PLAG1 Sponge network 6.998 0 1.043 0.00037 0.33
7 RP11-445P17.8 hsa-miR-125b-2-3p;hsa-miR-139-5p;hsa-miR-144-3p;hsa-miR-195-3p;hsa-miR-199a-3p;hsa-miR-199b-3p;hsa-miR-29a-3p;hsa-miR-29c-3p;hsa-miR-30a-3p;hsa-miR-30e-3p 10 PLAG1 Sponge network 5.108 0 1.043 0.00037 0.329
8 LINC00355 hsa-let-7b-3p;hsa-miR-101-3p;hsa-miR-125b-2-3p;hsa-miR-139-5p;hsa-miR-144-3p;hsa-miR-195-3p;hsa-miR-195-5p;hsa-miR-199a-3p;hsa-miR-199b-3p;hsa-miR-22-5p;hsa-miR-30a-3p;hsa-miR-30a-5p;hsa-miR-30e-3p;hsa-miR-3607-3p;hsa-miR-424-5p;hsa-miR-497-5p 16 PLAG1 Sponge network 6.198 0 1.043 0.00037 0.317
9 RAD51-AS1 hsa-miR-125b-2-3p;hsa-miR-139-5p;hsa-miR-195-3p;hsa-miR-199a-3p;hsa-miR-199b-3p;hsa-miR-22-5p;hsa-miR-29a-3p;hsa-miR-29c-3p;hsa-miR-30a-3p;hsa-miR-3607-3p 10 PLAG1 Sponge network 1.632 0 1.043 0.00037 0.316
10 LUCAT1 hsa-let-7b-3p;hsa-miR-101-3p;hsa-miR-125b-2-3p;hsa-miR-139-5p;hsa-miR-144-3p;hsa-miR-195-3p;hsa-miR-195-5p;hsa-miR-199a-3p;hsa-miR-199b-3p;hsa-miR-30a-3p 10 PLAG1 Sponge network 3.096 1.0E-5 1.043 0.00037 0.315
11 RP11-458D21.1 hsa-let-7b-3p;hsa-miR-101-3p;hsa-miR-125b-2-3p;hsa-miR-139-5p;hsa-miR-144-3p;hsa-miR-195-3p;hsa-miR-195-5p;hsa-miR-199a-3p;hsa-miR-199b-3p;hsa-miR-22-5p;hsa-miR-29a-3p;hsa-miR-29c-3p;hsa-miR-30a-3p;hsa-miR-30a-5p 14 PLAG1 Sponge network 1.399 0 1.043 0.00037 0.311
12 RP11-328N19.1 hsa-let-7b-3p;hsa-miR-101-3p;hsa-miR-125b-2-3p;hsa-miR-139-5p;hsa-miR-144-3p;hsa-miR-195-3p;hsa-miR-195-5p;hsa-miR-199a-3p;hsa-miR-199b-3p;hsa-miR-22-5p;hsa-miR-29a-3p;hsa-miR-29c-3p;hsa-miR-30a-3p;hsa-miR-30a-5p;hsa-miR-3607-3p 15 PLAG1 Sponge network 7.657 0 1.043 0.00037 0.306
13 RP1-228H13.5 hsa-let-7b-3p;hsa-miR-101-3p;hsa-miR-125b-2-3p;hsa-miR-139-5p;hsa-miR-144-3p;hsa-miR-195-3p;hsa-miR-195-5p;hsa-miR-22-5p;hsa-miR-29a-3p;hsa-miR-29c-3p;hsa-miR-30a-3p;hsa-miR-30a-5p;hsa-miR-30e-3p;hsa-miR-3607-3p 14 PLAG1 Sponge network 1.554 0 1.043 0.00037 0.297
14 CTD-3037G24.4 hsa-miR-101-3p;hsa-miR-125b-2-3p;hsa-miR-139-5p;hsa-miR-144-3p;hsa-miR-195-3p;hsa-miR-199a-3p;hsa-miR-199b-3p;hsa-miR-22-5p;hsa-miR-30a-3p;hsa-miR-30e-3p 10 PLAG1 Sponge network 4.594 0 1.043 0.00037 0.296
15 RP11-480I12.7 hsa-let-7b-3p;hsa-miR-101-3p;hsa-miR-125b-2-3p;hsa-miR-139-5p;hsa-miR-144-3p;hsa-miR-195-5p;hsa-miR-199a-3p;hsa-miR-199b-3p;hsa-miR-22-5p;hsa-miR-29a-3p;hsa-miR-29c-3p;hsa-miR-30a-3p;hsa-miR-30e-3p;hsa-miR-424-5p;hsa-miR-497-5p 15 PLAG1 Sponge network 2.03 0 1.043 0.00037 0.292
16 TMCC1-AS1 hsa-let-7b-3p;hsa-miR-101-3p;hsa-miR-125b-2-3p;hsa-miR-139-5p;hsa-miR-144-3p;hsa-miR-195-3p;hsa-miR-195-5p;hsa-miR-199a-3p;hsa-miR-199b-3p;hsa-miR-22-5p;hsa-miR-29a-3p;hsa-miR-29c-3p;hsa-miR-30a-3p;hsa-miR-30a-5p;hsa-miR-3607-3p;hsa-miR-424-5p;hsa-miR-497-5p 17 PLAG1 Sponge network 2.298 0 1.043 0.00037 0.28
17 RP11-774D14.1 hsa-let-7b-3p;hsa-miR-101-3p;hsa-miR-139-5p;hsa-miR-144-3p;hsa-miR-195-5p;hsa-miR-199a-3p;hsa-miR-199b-3p;hsa-miR-29c-3p;hsa-miR-30a-3p;hsa-miR-30a-5p;hsa-miR-3607-3p 11 PLAG1 Sponge network 6.64 0 1.043 0.00037 0.279
18 LINC01004 hsa-let-7b-3p;hsa-miR-101-3p;hsa-miR-125b-2-3p;hsa-miR-139-5p;hsa-miR-144-3p;hsa-miR-195-3p;hsa-miR-195-5p;hsa-miR-199a-3p;hsa-miR-199b-3p;hsa-miR-29a-3p;hsa-miR-29c-3p;hsa-miR-30a-3p;hsa-miR-424-5p;hsa-miR-497-5p 14 PLAG1 Sponge network 2.116 0 1.043 0.00037 0.275
19 AC074117.10 hsa-let-7b-3p;hsa-miR-101-3p;hsa-miR-125b-2-3p;hsa-miR-139-5p;hsa-miR-144-3p;hsa-miR-195-3p;hsa-miR-195-5p;hsa-miR-199a-3p;hsa-miR-199b-3p;hsa-miR-22-5p;hsa-miR-29a-3p;hsa-miR-29c-3p;hsa-miR-30a-3p;hsa-miR-30e-3p;hsa-miR-424-5p;hsa-miR-497-5p 16 PLAG1 Sponge network 1.254 0 1.043 0.00037 0.27
20 AC018890.6 hsa-let-7b-3p;hsa-miR-101-3p;hsa-miR-125b-2-3p;hsa-miR-139-5p;hsa-miR-144-3p;hsa-miR-195-3p;hsa-miR-195-5p;hsa-miR-199a-3p;hsa-miR-199b-3p;hsa-miR-29a-3p;hsa-miR-29c-3p;hsa-miR-30a-3p;hsa-miR-30a-5p;hsa-miR-30e-3p;hsa-miR-3607-3p 15 PLAG1 Sponge network 3.613 0 1.043 0.00037 0.27
21 PART1 hsa-let-7b-3p;hsa-miR-101-3p;hsa-miR-125b-2-3p;hsa-miR-139-5p;hsa-miR-144-3p;hsa-miR-195-3p;hsa-miR-195-5p;hsa-miR-199a-3p;hsa-miR-199b-3p;hsa-miR-30e-3p;hsa-miR-424-5p;hsa-miR-497-5p 12 PLAG1 Sponge network 3.525 1.0E-5 1.043 0.00037 0.267
22 HCG20 hsa-let-7b-3p;hsa-miR-101-3p;hsa-miR-139-5p;hsa-miR-144-3p;hsa-miR-195-3p;hsa-miR-195-5p;hsa-miR-199a-3p;hsa-miR-199b-3p;hsa-miR-22-5p;hsa-miR-29c-3p;hsa-miR-30a-3p 11 PLAG1 Sponge network 3.632 0 1.043 0.00037 0.267
23 SNHG1 hsa-let-7b-3p;hsa-miR-101-3p;hsa-miR-125b-2-3p;hsa-miR-139-5p;hsa-miR-144-3p;hsa-miR-195-3p;hsa-miR-195-5p;hsa-miR-199a-3p;hsa-miR-199b-3p;hsa-miR-22-5p;hsa-miR-29a-3p;hsa-miR-29c-3p;hsa-miR-30a-3p;hsa-miR-30a-5p;hsa-miR-30e-3p;hsa-miR-3607-3p;hsa-miR-424-5p;hsa-miR-497-5p 18 PLAG1 Sponge network 2.013 0 1.043 0.00037 0.266
24 KB-431C1.4 hsa-let-7b-3p;hsa-miR-101-3p;hsa-miR-139-5p;hsa-miR-144-3p;hsa-miR-195-3p;hsa-miR-195-5p;hsa-miR-199a-3p;hsa-miR-199b-3p;hsa-miR-22-5p;hsa-miR-29a-3p;hsa-miR-29c-3p;hsa-miR-30a-3p;hsa-miR-30e-3p;hsa-miR-3607-3p 14 PLAG1 Sponge network 1.573 0 1.043 0.00037 0.265
25 RP4-758J18.13 hsa-let-7b-3p;hsa-miR-101-3p;hsa-miR-125b-2-3p;hsa-miR-139-5p;hsa-miR-144-3p;hsa-miR-195-3p;hsa-miR-195-5p;hsa-miR-199a-3p;hsa-miR-199b-3p;hsa-miR-30a-3p;hsa-miR-3607-3p 11 PLAG1 Sponge network 1.374 0 1.043 0.00037 0.265
26 RP5-857K21.15 hsa-miR-101-3p;hsa-miR-125b-2-3p;hsa-miR-139-5p;hsa-miR-144-3p;hsa-miR-195-5p;hsa-miR-199a-3p;hsa-miR-199b-3p;hsa-miR-22-5p;hsa-miR-30a-3p;hsa-miR-30a-5p 10 PLAG1 Sponge network 3.87 0 1.043 0.00037 0.264
27 CTA-204B4.2 hsa-let-7b-3p;hsa-miR-101-3p;hsa-miR-125b-2-3p;hsa-miR-139-5p;hsa-miR-144-3p;hsa-miR-199a-3p;hsa-miR-199b-3p;hsa-miR-22-5p;hsa-miR-29a-3p;hsa-miR-29c-3p;hsa-miR-30a-3p 11 PLAG1 Sponge network 2.112 0 1.043 0.00037 0.264
28 RP11-317N12.1 hsa-let-7b-3p;hsa-miR-101-3p;hsa-miR-125b-2-3p;hsa-miR-144-3p;hsa-miR-195-5p;hsa-miR-199a-3p;hsa-miR-199b-3p;hsa-miR-30a-3p;hsa-miR-30a-5p;hsa-miR-3607-3p;hsa-miR-497-5p 11 PLAG1 Sponge network 3.993 0 1.043 0.00037 0.256
29 FLVCR1-AS1 hsa-let-7b-3p;hsa-miR-101-3p;hsa-miR-125b-2-3p;hsa-miR-139-5p;hsa-miR-144-3p;hsa-miR-195-3p;hsa-miR-195-5p;hsa-miR-199a-3p;hsa-miR-199b-3p;hsa-miR-22-5p;hsa-miR-30a-3p;hsa-miR-30e-3p 12 PLAG1 Sponge network 2.147 0 1.043 0.00037 0.256
30 RP11-108L7.15 hsa-miR-101-3p;hsa-miR-125b-2-3p;hsa-miR-139-5p;hsa-miR-144-3p;hsa-miR-195-5p;hsa-miR-199a-3p;hsa-miR-199b-3p;hsa-miR-22-5p;hsa-miR-30a-3p;hsa-miR-30e-3p 10 PLAG1 Sponge network 5.141 0 1.043 0.00037 0.254
31 RP11-328J2.1 hsa-let-7b-3p;hsa-miR-101-3p;hsa-miR-144-3p;hsa-miR-195-3p;hsa-miR-195-5p;hsa-miR-199a-3p;hsa-miR-199b-3p;hsa-miR-30a-3p;hsa-miR-30a-5p;hsa-miR-424-5p;hsa-miR-497-5p 11 PLAG1 Sponge network 6.122 0 1.043 0.00037 0.252
32 HNRNPU-AS1 hsa-let-7b-3p;hsa-miR-101-3p;hsa-miR-125b-2-3p;hsa-miR-139-5p;hsa-miR-144-3p;hsa-miR-195-3p;hsa-miR-195-5p;hsa-miR-29a-3p;hsa-miR-29c-3p;hsa-miR-30a-3p;hsa-miR-30e-3p;hsa-miR-424-5p;hsa-miR-497-5p 13 PLAG1 Sponge network 1.246 0 1.043 0.00037 0.252
33 RP4-717I23.3 hsa-let-7b-3p;hsa-miR-101-3p;hsa-miR-125b-2-3p;hsa-miR-139-5p;hsa-miR-144-3p;hsa-miR-195-3p;hsa-miR-195-5p;hsa-miR-199a-3p;hsa-miR-199b-3p;hsa-miR-22-5p;hsa-miR-29a-3p;hsa-miR-29c-3p;hsa-miR-30a-3p;hsa-miR-30e-3p;hsa-miR-3607-3p 15 PLAG1 Sponge network 1.867 0 1.043 0.00037 0.25

Quest ID: 861f0e081142a01a15fa19f73cf86905