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This regulatory network was inferred from the input dataset. The miRNAs and mRNAs are presented as round and rectangle nodes respectively. The numerical value popped up upon mouse over the gene node is the log2 transformed fold-change of the gene expression between the two groups. All of the nodes are clickable, and the detailed information of the miRNAs/mRNAs and related cancer pathway will be displayed in another window. The edges between nodes are supported by both interactions (predicted or experimentally verified) and correlations learnt from cancer dataset. The numerical value popped up upon mouse over the edge is the correlation beat value (effect size) between the two nodes. The experimental evidences of the edges reported in previous cancer studies are highlighted by red/orange color. All of these information can be accessed by the "mouse-over" action. This network shows a full map of the miRNA-mRNA regulation of the input gene list(s), and the hub miRNAs (with the high network degree/betweenness centrality) would be the potential cancer drivers or tumor suppressors. The full result table can be accessed in the "Regulations" tab.

"miRNACancerMAP" is also a network visualization tool for users to draw their regulatory network by personal customization. Users can set the complexity of the network by limiting the number of nodes or edges. And the color of the nodes can be defined by different categories of the mRNAs and miRNAs, such as Gene-Ontology, pathway, and expression status. Users can also select to use network degree or network betweenness centrality to define the node size. And edges can be black or colored by the correlation. Purple edge means negative correlation (mostly found between miRNA and mRNA), and blue edge means positive correlation (found in PPI or miRNA-miRNA sponge effect). We can also add the protein-protein interactions (PPI) into the network. This result will show the cluster of genes regulated by some specific miRNAs. Additionally, miRNA-miRNA edges can be added by the "miRNA sponge" button, presenting some clusters of miRNAs that have the interactions via sponge effect.

miRNA-gene regulations

(Download full result)

Num microRNA           Gene miRNA log2FC miRNA pvalue Gene log2FC Gene pvalue Interaction Correlation beta Correlation P-value PMID Reported in cancer studies
1 hsa-miR-29a-3p AKT2 0.2 0.85995 -0.01 0.98435 MirTarget -0.12 0.00214 24076586 Furthermore a feed-back loop comprising of c-Myc miR-29 family and Akt2 were found in myeloid leukemogenesis
2 hsa-miR-106a-5p AKT3 -0.82 0.02545 0.09 0.82989 miRNATAP -0.16 0.00858 NA
3 hsa-miR-106b-5p AKT3 -0.39 0.38964 0.09 0.82989 miRNATAP -0.31 0.00102 NA
4 hsa-miR-107 AKT3 -0.29 0.76966 0.09 0.82989 PITA; miRanda -0.29 0.00414 NA
5 hsa-miR-335-3p AKT3 0.07 0.89349 0.09 0.82989 mirMAP -0.16 0.00961 NA
6 hsa-miR-93-5p AKT3 -0.38 0.73231 0.09 0.82989 miRNATAP -0.27 0.00266 NA
7 hsa-miR-155-5p CAB39L -0.32 0.67318 0.46 0.20249 miRNAWalker2 validate -0.12 0.00272 NA
8 hsa-miR-192-5p CAB39L -0 0.99638 0.46 0.20249 miRNAWalker2 validate -0.16 4.0E-5 NA
9 hsa-miR-342-3p CAB39L -0.23 0.73996 0.46 0.20249 miRanda -0.17 0.00245 NA
10 hsa-miR-361-5p CAB39L -0.28 0.72855 0.46 0.20249 MirTarget; miRanda -0.17 0.03074 NA
11 hsa-miR-30e-5p DDIT4 -0 0.99712 0.21 0.74135 MirTarget -0.23 0.00373 NA
12 hsa-miR-92b-3p DDIT4 0.45 0.64619 0.21 0.74135 miRNATAP -0.22 0.00019 NA
13 hsa-miR-15b-5p EIF4B 0.25 0.79071 0.25 0.73129 miRNATAP -0.12 0.00683 NA
14 hsa-miR-185-5p EIF4B -0.65 0.11792 0.25 0.73129 MirTarget -0.14 1.0E-5 NA
15 hsa-miR-23b-5p EIF4B 0.07 0.82803 0.25 0.73129 miRNAWalker2 validate -0.11 0.00024 NA
16 hsa-miR-330-5p EIF4B -0.15 0.78726 0.25 0.73129 miRNATAP -0.12 0.00063 NA
17 hsa-miR-339-5p EIF4B -0.12 0.81428 0.25 0.73129 miRanda -0.1 0.00325 NA
18 hsa-miR-342-3p EIF4B -0.23 0.73996 0.25 0.73129 miRanda -0.18 0 NA
19 hsa-miR-2110 EIF4E -0.36 0.45154 0.32 0.37219 mirMAP -0.11 0.00023 NA
20 hsa-miR-26a-5p EIF4E 0.05 0.95522 0.32 0.37219 mirMAP -0.21 0 NA
21 hsa-miR-30c-5p EIF4E -0.18 0.83318 0.32 0.37219 mirMAP -0.19 0 NA
22 hsa-miR-320c EIF4E 0.09 0.78554 0.32 0.37219 MirTarget; miRanda -0.12 0.00016 NA
23 hsa-miR-361-5p EIF4E -0.28 0.72855 0.32 0.37219 miRanda; mirMAP -0.12 0.02086 NA
24 hsa-miR-378a-3p EIF4E -0.43 0.62879 0.32 0.37219 mirMAP -0.11 4.0E-5 NA
25 hsa-miR-29a-3p EIF4E2 0.2 0.85995 0.11 0.83172 MirTarget -0.12 0 NA
26 hsa-miR-125a-5p EIF4EBP1 -0.01 0.99489 -0.21 0.69191 miRNAWalker2 validate; MirTarget; miRanda; miRNATAP -0.26 0.00151 26646586 Increased expression of miR-125a and miR-125b inhibited invasion and migration of SKOV3 and OVCAR-429 ovarian cancer cells and was associated with a decrease in EIF4EBP1 expression
27 hsa-miR-362-5p IGF1 -0.36 0.45216 0.39 0.49442 mirMAP -0.14 0.02288 NA
28 hsa-miR-130a-3p MAPK1 -0.02 0.97739 -0.3 0.62729 mirMAP -0.13 0.00027 NA
29 hsa-miR-148b-3p MAPK1 0.09 0.91471 -0.3 0.62729 mirMAP -0.12 0.01943 NA
30 hsa-miR-342-3p PDPK1 -0.23 0.73996 -0.08 0.87808 mirMAP -0.1 0.00367 NA
31 hsa-miR-34a-5p PGF -0.69 0.19575 -0.1 0.74683 miRNATAP -0.14 0.0236 NA
32 hsa-miR-429 PGF -0.6 0.12897 -0.1 0.74683 miRNATAP -0.16 0.00176 NA
33 hsa-miR-335-3p PIK3CG 0.07 0.89349 -0.35 0.33299 mirMAP -0.16 0.00995 NA
34 hsa-miR-17-5p PIK3R1 -0.64 0.32067 0.18 0.73919 MirTarget; TargetScan; miRNATAP -0.11 0.02188 NA
35 hsa-miR-221-3p PIK3R1 -0.26 0.74402 0.18 0.73919 MirTarget -0.21 2.0E-5 NA
36 hsa-miR-222-3p PIK3R1 -0.23 0.72665 0.18 0.73919 MirTarget -0.21 1.0E-5 NA
37 hsa-miR-629-3p PIK3R1 -0.46 0.20921 0.18 0.73919 MirTarget -0.18 7.0E-5 NA
38 hsa-miR-28-5p PIK3R2 -0.05 0.91096 0.14 0.83378 miRanda -0.1 0.0459 NA
39 hsa-miR-423-5p PIK3R2 -0.31 0.65889 0.14 0.83378 MirTarget -0.12 0.02884 NA
40 hsa-miR-1271-5p PIK3R3 -0.12 0.70353 -0.03 0.95678 mirMAP -0.2 0.0004 NA
41 hsa-miR-92a-3p PIK3R3 0.02 0.99144 -0.03 0.95678 MirTarget; miRNATAP -0.3 0.00023 NA
42 hsa-miR-92b-3p PIK3R3 0.45 0.64619 -0.03 0.95678 MirTarget; miRNATAP -0.18 0.00061 NA
43 hsa-miR-130a-3p PRKAA1 -0.02 0.97739 0 0.99281 MirTarget; miRNATAP -0.13 1.0E-5 NA
44 hsa-let-7b-3p PRKAA2 0.31 0.68425 -0.18 0.67689 mirMAP -0.21 0.01354 NA
45 hsa-let-7b-5p PRKAA2 0.4 0.78341 -0.18 0.67689 miRNAWalker2 validate; MirTarget -0.2 0.00992 NA
46 hsa-miR-150-3p PRKAA2 -0.42 0.37145 -0.18 0.67689 MirTarget; miRNATAP -0.11 0.02408 NA
47 hsa-miR-195-3p PRKAA2 -0.16 0.71189 -0.18 0.67689 mirMAP -0.22 0.00097 NA
48 hsa-miR-21-3p PRKAA2 0.13 0.87791 -0.18 0.67689 mirMAP -0.19 0.00316 NA
49 hsa-miR-214-5p PRKAA2 0.41 0.38386 -0.18 0.67689 MirTarget -0.15 0.01379 NA
50 hsa-miR-141-3p RHEB -0.37 0.42836 0.19 0.74355 MirTarget; TargetScan; miRNATAP -0.11 0.00269 NA
51 hsa-miR-342-3p RICTOR -0.23 0.73996 -0.28 0.52193 MirTarget; PITA; miRanda; miRNATAP -0.12 0.0004 NA
52 hsa-miR-744-5p RPS6 -0.17 0.80204 0.34 0.71928 miRNAWalker2 validate -0.19 0.00159 NA
53 hsa-miR-125a-5p RPS6KA1 -0.01 0.99489 0.01 0.98982 MirTarget; PITA; miRanda -0.23 0.00082 NA
54 hsa-miR-125b-5p RPS6KA1 0.01 0.99415 0.01 0.98982 miRNAWalker2 validate; miRTarBase; MirTarget; miRNATAP -0.13 0.0014 NA
55 hsa-miR-17-5p RPS6KA2 -0.64 0.32067 -0.1 0.85218 TargetScan -0.14 0.00238 NA
56 hsa-miR-636 RPS6KA2 -0.11 0.71062 -0.1 0.85218 MirTarget -0.12 0.00485 NA
57 hsa-miR-181c-5p RPS6KA3 -0.26 0.64547 -0.02 0.97429 MirTarget; mirMAP; miRNATAP -0.13 7.0E-5 NA
58 hsa-miR-125a-5p RPS6KB2 -0.01 0.99489 -0 0.99992 miRanda -0.19 0.00028 NA
59 hsa-let-7d-5p ULK2 0.01 0.98839 -0.47 0.24243 MirTarget -0.15 0.00122 NA
60 hsa-let-7f-1-3p ULK2 0.13 0.68644 -0.47 0.24243 MirTarget -0.11 0.00372 NA
61 hsa-miR-1266-5p ULK2 0.19 0.74972 -0.47 0.24243 MirTarget -0.11 0.00404 NA
62 hsa-miR-326 ULK3 0.31 0.65358 -0.05 0.92018 miRanda -0.17 0 NA
63 hsa-miR-491-5p ULK3 -0.18 0.55955 -0.05 0.92018 miRanda -0.13 0.00609 NA
64 hsa-miR-744-5p ULK3 -0.17 0.80204 -0.05 0.92018 miRNAWalker2 validate -0.21 0.00012 NA
65 hsa-miR-129-5p VEGFA 0.42 0.45424 -0.63 0.34942 miRanda -0.11 0.00029 NA

Over-represented Gene Ontology Biological Process

NumGOOverlapSizeP ValueAdj. P Value
1 INTRACELLULAR SIGNAL TRANSDUCTION 19 1572 3.228e-15 1.502e-11
2 PROTEIN PHOSPHORYLATION 16 944 9.563e-15 2.225e-11
3 PHOSPHORYLATION 17 1228 2.536e-14 3.933e-11
4 REGULATION OF CELLULAR AMIDE METABOLIC PROCESS 11 354 7.511e-13 8.737e-10
5 PHOSPHATE CONTAINING COMPOUND METABOLIC PROCESS 18 1977 3.753e-12 3.493e-09
6 PEPTIDYL SERINE MODIFICATION 8 148 2.038e-11 1.499e-08
7 REGULATION OF GLUCOSE IMPORT IN RESPONSE TO INSULIN STIMULUS 5 17 2.256e-11 1.499e-08
8 TRANSMEMBRANE RECEPTOR PROTEIN TYROSINE KINASE SIGNALING PATHWAY 11 498 2.995e-11 1.742e-08
9 CELLULAR RESPONSE TO HORMONE STIMULUS 11 552 9.001e-11 4.653e-08
10 REGULATION OF GLUCOSE IMPORT 6 60 2.018e-10 9.389e-08
11 CELLULAR RESPONSE TO OXYGEN CONTAINING COMPOUND 12 799 2.57e-10 1.021e-07
12 POSTTRANSCRIPTIONAL REGULATION OF GENE EXPRESSION 10 448 2.633e-10 1.021e-07
13 CELLULAR RESPONSE TO NITROGEN COMPOUND 10 505 8.412e-10 3.011e-07
14 CELLULAR RESPONSE TO INSULIN STIMULUS 7 146 9.955e-10 3.088e-07
15 ENZYME LINKED RECEPTOR PROTEIN SIGNALING PATHWAY 11 689 9.43e-10 3.088e-07
16 POSITIVE REGULATION OF GLUCOSE IMPORT IN RESPONSE TO INSULIN STIMULUS 4 12 1.509e-09 4.389e-07
17 CELLULAR RESPONSE TO PEPTIDE 8 274 2.747e-09 7.518e-07
18 POSITIVE REGULATION OF GLUCOSE TRANSPORT 5 42 3.027e-09 7.826e-07
19 CELLULAR RESPONSE TO ORGANIC SUBSTANCE 15 1848 3.384e-09 8.287e-07
20 CELLULAR RESPONSE TO ENDOGENOUS STIMULUS 12 1008 3.62e-09 8.421e-07
21 REGULATION OF GLUCOSE TRANSPORT 6 100 4.626e-09 1.025e-06
22 POSITIVE REGULATION OF RESPONSE TO STIMULUS 15 1929 6.117e-09 1.294e-06
23 RESPONSE TO INSULIN 7 205 1.058e-08 2.056e-06
24 RESPONSE TO OXYGEN CONTAINING COMPOUND 13 1381 1.078e-08 2.056e-06
25 NEGATIVE REGULATION OF CELL DEATH 11 872 1.104e-08 2.056e-06
26 RESPONSE TO HORMONE 11 893 1.413e-08 2.529e-06
27 REGULATION OF CELLULAR RESPONSE TO INSULIN STIMULUS 5 59 1.753e-08 2.913e-06
28 INOSITOL LIPID MEDIATED SIGNALING 6 124 1.694e-08 2.913e-06
29 REGULATION OF CELL DEATH 13 1472 2.319e-08 3.721e-06
30 POSITIVE REGULATION OF CELLULAR RESPONSE TO INSULIN STIMULUS 4 23 2.671e-08 4.143e-06
31 REGULATION OF TOR SIGNALING 5 68 3.618e-08 5.431e-06
32 PHOSPHATIDYLINOSITOL 3 KINASE SIGNALING 4 25 3.809e-08 5.538e-06
33 CELL DEATH 11 1001 4.575e-08 6.451e-06
34 RESPONSE TO PEPTIDE 8 404 5.644e-08 7.724e-06
35 REGULATION OF PHOSPHORUS METABOLIC PROCESS 13 1618 7.145e-08 9.498e-06
36 INSULIN RECEPTOR SIGNALING PATHWAY 5 80 8.249e-08 1.066e-05
37 REGULATION OF LIPID METABOLIC PROCESS 7 282 9.452e-08 1.189e-05
38 RESPONSE TO NITROGEN COMPOUND 10 859 1.315e-07 1.61e-05
39 REGULATION OF GENERATION OF PRECURSOR METABOLITES AND ENERGY 5 89 1.412e-07 1.685e-05
40 REGULATION OF NUCLEOTIDE CATABOLIC PROCESS 4 36 1.755e-07 2.041e-05
41 RESPONSE TO ENDOGENOUS STIMULUS 12 1450 2.055e-07 2.332e-05
42 REGULATION OF CELL CYCLE 10 949 3.316e-07 3.506e-05
43 REGULATION OF CELLULAR CARBOHYDRATE CATABOLIC PROCESS 4 42 3.315e-07 3.506e-05
44 REGULATION OF CARBOHYDRATE CATABOLIC PROCESS 4 42 3.315e-07 3.506e-05
45 REGULATION OF PEPTIDYL SERINE PHOSPHORYLATION 5 118 5.788e-07 5.985e-05
46 PHOSPHATIDYLINOSITOL 3 PHOSPHATE BIOSYNTHETIC PROCESS 4 49 6.234e-07 6.043e-05
47 REGULATION OF NUCLEOSIDE METABOLIC PROCESS 4 49 6.234e-07 6.043e-05
48 REGULATION OF ATP METABOLIC PROCESS 4 49 6.234e-07 6.043e-05
49 REGULATION OF COENZYME METABOLIC PROCESS 4 50 6.769e-07 6.3e-05
50 REGULATION OF COFACTOR METABOLIC PROCESS 4 50 6.769e-07 6.3e-05
51 REGULATION OF INTRACELLULAR SIGNAL TRANSDUCTION 12 1656 8.649e-07 7.891e-05
52 TOR SIGNALING 3 16 1.359e-06 0.0001216
53 TRANSLATIONAL INITIATION 5 146 1.661e-06 0.0001431
54 POSITIVE REGULATION OF NUCLEOTIDE CATABOLIC PROCESS 3 17 1.649e-06 0.0001431
55 RESPONSE TO ACTIVITY 4 69 2.495e-06 0.0002111
56 POSITIVE REGULATION OF CELL COMMUNICATION 11 1532 3.254e-06 0.0002698
57 VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR SIGNALING PATHWAY 4 74 3.305e-06 0.0002698
58 GLUCOSE HOMEOSTASIS 5 170 3.509e-06 0.0002721
59 POSITIVE REGULATION OF CARBOHYDRATE METABOLIC PROCESS 4 75 3.488e-06 0.0002721
60 CARBOHYDRATE HOMEOSTASIS 5 170 3.509e-06 0.0002721
61 REGULATION OF CARBOHYDRATE METABOLIC PROCESS 5 172 3.716e-06 0.0002834
62 RESPONSE TO OXYGEN LEVELS 6 311 3.804e-06 0.0002855
63 CELLULAR RESPONSE TO STRESS 11 1565 4.006e-06 0.0002958
64 POSITIVE REGULATION OF NUCLEOSIDE METABOLIC PROCESS 3 24 4.877e-06 0.0003491
65 POSITIVE REGULATION OF ATP METABOLIC PROCESS 3 24 4.877e-06 0.0003491
66 REGULATION OF CATABOLIC PROCESS 8 731 4.975e-06 0.0003507
67 CELL CYCLE 10 1316 6.454e-06 0.0004482
68 NEGATIVE REGULATION OF CYSTEINE TYPE ENDOPEPTIDASE ACTIVITY 4 88 6.609e-06 0.0004495
69 RESPONSE TO ABIOTIC STIMULUS 9 1024 6.666e-06 0.0004495
70 POSITIVE REGULATION OF PHOSPHATE METABOLIC PROCESS 9 1036 7.327e-06 0.0004802
71 POSITIVE REGULATION OF PHOSPHORUS METABOLIC PROCESS 9 1036 7.327e-06 0.0004802
72 REGULATION OF KINASE ACTIVITY 8 776 7.717e-06 0.0004987
73 POSITIVE REGULATION OF CELLULAR PROTEIN LOCALIZATION 6 360 8.793e-06 0.0005605
74 NEGATIVE REGULATION OF TOR SIGNALING 3 30 9.727e-06 0.0006116
75 REGULATION OF NUCLEOTIDE METABOLIC PROCESS 5 211 1.005e-05 0.0006237
76 POSITIVE REGULATION OF GENE EXPRESSION 11 1733 1.073e-05 0.0006532
77 NEGATIVE REGULATION OF PROTEIN METABOLIC PROCESS 9 1087 1.081e-05 0.0006532
78 PEPTIDYL AMINO ACID MODIFICATION 8 841 1.388e-05 0.0008279
79 PROTEIN KINASE B SIGNALING 3 34 1.428e-05 0.0008413
80 POSITIVE REGULATION OF IMMUNE SYSTEM PROCESS 8 867 1.731e-05 0.001007
81 PHOSPHATIDYLINOSITOL BIOSYNTHETIC PROCESS 4 120 2.258e-05 0.001297
82 REGULATION OF PHOSPHATIDYLINOSITOL 3 KINASE ACTIVITY 3 40 2.345e-05 0.001331
83 NEGATIVE REGULATION OF CELL CYCLE 6 433 2.501e-05 0.001402
84 NEGATIVE REGULATION OF CELLULAR AMIDE METABOLIC PROCESS 4 131 3.186e-05 0.001765
85 REGULATION OF TRANSFERASE ACTIVITY 8 946 3.243e-05 0.001775
86 REGULATION OF PHOSPHATIDYLINOSITOL 3 KINASE SIGNALING 4 138 3.907e-05 0.002114
87 REGULATION OF LIPID KINASE ACTIVITY 3 48 4.075e-05 0.002179
88 PLATELET ACTIVATION 4 142 4.368e-05 0.002284
89 FC EPSILON RECEPTOR SIGNALING PATHWAY 4 142 4.368e-05 0.002284
90 IMMUNE EFFECTOR PROCESS 6 486 4.773e-05 0.002467
91 T CELL RECEPTOR SIGNALING PATHWAY 4 146 4.869e-05 0.002489
92 POSITIVE REGULATION OF CELL GROWTH 4 148 5.134e-05 0.002595
93 REGULATION OF LIPID CATABOLIC PROCESS 3 52 5.187e-05 0.002595
94 CELL CYCLE ARREST 4 154 5.994e-05 0.002926
95 POSITIVE REGULATION OF EPITHELIAL CELL PROLIFERATION 4 154 5.994e-05 0.002926
96 AMIDE BIOSYNTHETIC PROCESS 6 507 6.037e-05 0.002926
97 POSITIVE REGULATION OF CELL ACTIVATION 5 311 6.45e-05 0.003094
98 REGULATION OF PHOSPHOLIPID METABOLIC PROCESS 3 61 8.376e-05 0.003977
99 LIPID BIOSYNTHETIC PROCESS 6 539 8.469e-05 0.00398
100 REGULATION OF CELLULAR PROTEIN LOCALIZATION 6 552 9.656e-05 0.004493
101 POSITIVE REGULATION OF BIOSYNTHETIC PROCESS 10 1805 0.0001003 0.004576
102 REGULATION OF TRANSPORT 10 1804 9.984e-05 0.004576
103 RESPONSE TO EXTERNAL STIMULUS 10 1821 0.0001081 0.004882
104 REGULATION OF DNA TEMPLATED TRANSCRIPTION IN RESPONSE TO STRESS 3 67 0.0001109 0.00496
105 CELL ACTIVATION 6 568 0.000113 0.005006
106 PEPTIDE METABOLIC PROCESS 6 571 0.0001163 0.005057
107 POSITIVE REGULATION OF ENDOTHELIAL CELL PROLIFERATION 3 68 0.0001159 0.005057
108 POSITIVE REGULATION OF PROTEIN MODIFICATION PROCESS 8 1135 0.0001176 0.005066
109 FATTY ACID HOMEOSTASIS 2 12 0.0001237 0.005279
110 REGULATION OF CELL DIFFERENTIATION 9 1492 0.0001312 0.005499
111 POSITIVE REGULATION OF PROTEIN METABOLIC PROCESS 9 1492 0.0001312 0.005499
112 PHOSPHATIDYLINOSITOL METABOLIC PROCESS 4 193 0.0001436 0.005964
113 POSITIVE REGULATION OF INTRACELLULAR TRANSPORT 5 370 0.000146 0.006012
114 ANTIGEN RECEPTOR MEDIATED SIGNALING PATHWAY 4 195 0.0001494 0.006096
115 CHEMICAL HOMEOSTASIS 7 874 0.0001571 0.006259
116 POSITIVE REGULATION OF CELL ADHESION 5 376 0.0001574 0.006259
117 RESPIRATORY SYSTEM DEVELOPMENT 4 197 0.0001553 0.006259
118 POSITIVE REGULATION OF INTRACELLULAR SIGNAL TRANSDUCTION 7 876 0.0001593 0.006283
119 INSULIN LIKE GROWTH FACTOR RECEPTOR SIGNALING PATHWAY 2 14 0.0001702 0.006656
120 LYMPHOCYTE COSTIMULATION 3 78 0.0001743 0.006757
121 ERBB SIGNALING PATHWAY 3 79 0.000181 0.006959
122 FC RECEPTOR SIGNALING PATHWAY 4 206 0.0001844 0.006975
123 REGULATION OF INTRACELLULAR TRANSPORT 6 621 0.0001838 0.006975
124 REGULATION OF CELL GROWTH 5 391 0.0001888 0.007029
125 POSITIVE REGULATION OF MAP KINASE ACTIVITY 4 207 0.0001878 0.007029
126 LIPID MODIFICATION 4 210 0.0001985 0.007214
127 AUTOPHAGY 5 394 0.0001956 0.007214
128 REGULATION OF CELL ADHESION 6 629 0.000197 0.007214
129 GLYCEROLIPID BIOSYNTHETIC PROCESS 4 211 0.0002021 0.007234
130 REGULATION OF TRANSLATIONAL INITIATION 3 82 0.0002021 0.007234
131 REGULATION OF CYSTEINE TYPE ENDOPEPTIDASE ACTIVITY 4 213 0.0002095 0.007442
132 IMMUNE SYSTEM PROCESS 10 1984 0.000221 0.007792
133 POSITIVE REGULATION OF TRANSPORT 7 936 0.0002398 0.008388
134 REGULATION OF ENERGY HOMEOSTASIS 2 17 0.0002537 0.008745
135 POSITIVE REGULATION OF GLYCOGEN METABOLIC PROCESS 2 17 0.0002537 0.008745
136 POSITIVE REGULATION OF LOCOMOTION 5 420 0.0002631 0.008934
137 MOVEMENT OF CELL OR SUBCELLULAR COMPONENT 8 1275 0.0002627 0.008934
138 CELL PROLIFERATION 6 672 0.0002816 0.009412
139 CELLULAR RESPONSE TO PROSTAGLANDIN E STIMULUS 2 18 0.0002852 0.009412
140 RESPONSE TO CAFFEINE 2 18 0.0002852 0.009412
141 ACTIVATION OF IMMUNE RESPONSE 5 427 0.0002839 0.009412
142 PHOSPHOLIPID BIOSYNTHETIC PROCESS 4 235 0.0003048 0.009987
NumGOOverlapSizeP ValueAdj. P Value
1 KINASE ACTIVITY 16 842 1.605e-15 1.491e-12
2 PROTEIN SERINE THREONINE KINASE ACTIVITY 13 445 7.612e-15 3.536e-12
3 TRANSFERASE ACTIVITY TRANSFERRING PHOSPHORUS CONTAINING GROUPS 16 992 2.068e-14 6.405e-12
4 PROTEIN KINASE ACTIVITY 13 640 7.876e-13 1.829e-10
5 KINASE BINDING 10 606 4.859e-09 9.028e-07
6 ADENYL NUCLEOTIDE BINDING 13 1514 3.245e-08 5.024e-06
7 RIBONUCLEOTIDE BINDING 14 1860 3.945e-08 5.236e-06
8 ENZYME BINDING 13 1737 1.649e-07 1.915e-05
9 X1 PHOSPHATIDYLINOSITOL 3 KINASE ACTIVITY 4 43 3.652e-07 3.77e-05
10 PHOSPHATIDYLINOSITOL KINASE ACTIVITY 4 51 7.338e-07 6.817e-05
11 PHOSPHATIDYLINOSITOL 3 KINASE ACTIVITY 4 70 2.644e-06 0.0002233
12 INSULIN RECEPTOR BINDING 3 32 1.186e-05 0.0009183
13 PROTEIN SERINE THREONINE TYROSINE KINASE ACTIVITY 3 39 2.171e-05 0.001552
14 TRANSLATION INITIATION FACTOR ACTIVITY 3 51 4.892e-05 0.003246
15 PHOSPHATASE BINDING 4 162 7.297e-05 0.00452
16 RNA CAP BINDING 2 13 0.000146 0.008479
NumGOOverlapSizeP ValueAdj. P Value
1 PHOSPHATIDYLINOSITOL 3 KINASE COMPLEX 4 20 1.466e-08 8.56e-06
2 TRANSFERASE COMPLEX TRANSFERRING PHOSPHORUS CONTAINING GROUPS 6 237 7.871e-07 0.0002298

Over-represented Pathway

NumPathwayPathviewOverlapSizeP ValueAdj. P Value
1 hsa04150_mTOR_signaling_pathway 28 52 4.935e-77 8.884e-75
2 hsa04151_PI3K_AKT_signaling_pathway 21 351 7.841e-32 7.057e-30
3 hsa04910_Insulin_signaling_pathway 16 138 3.053e-28 1.832e-26
4 hsa04914_Progesterone.mediated_oocyte_maturation 11 87 1.108e-19 4.984e-18
5 hsa04722_Neurotrophin_signaling_pathway 10 127 8.855e-16 3.188e-14
6 hsa04510_Focal_adhesion 11 200 1.404e-15 4.211e-14
7 hsa04012_ErbB_signaling_pathway 9 87 2.353e-15 6.05e-14
8 hsa04370_VEGF_signaling_pathway 8 76 8.7e-14 1.958e-12
9 hsa04960_Aldosterone.regulated_sodium_reabsorption 7 42 1.219e-13 2.438e-12
10 hsa04666_Fc_gamma_R.mediated_phagocytosis 8 95 5.514e-13 9.925e-12
11 hsa04662_B_cell_receptor_signaling_pathway 7 75 8.701e-12 1.424e-10
12 hsa04664_Fc_epsilon_RI_signaling_pathway 7 79 1.266e-11 1.899e-10
13 hsa04014_Ras_signaling_pathway 9 236 2.164e-11 2.996e-10
14 hsa04973_Carbohydrate_digestion_and_absorption 6 44 2.889e-11 3.714e-10
15 hsa04620_Toll.like_receptor_signaling_pathway 7 102 7.897e-11 9.476e-10
16 hsa04660_T_cell_receptor_signaling_pathway 7 108 1.186e-10 1.334e-09
17 hsa04380_Osteoclast_differentiation 7 128 3.946e-10 4.178e-09
18 hsa04210_Apoptosis 6 89 2.279e-09 2.279e-08
19 hsa04062_Chemokine_signaling_pathway 7 189 6.028e-09 5.71e-08
20 hsa04630_Jak.STAT_signaling_pathway 6 155 6.434e-08 5.791e-07
21 hsa04140_Regulation_of_autophagy 4 34 1.384e-07 1.187e-06
22 hsa04114_Oocyte_meiosis 5 114 4.875e-07 3.989e-06
23 hsa04650_Natural_killer_cell_mediated_cytotoxicity 5 136 1.17e-06 9.159e-06
24 hsa04010_MAPK_signaling_pathway 6 268 1.61e-06 1.207e-05
25 hsa04920_Adipocytokine_signaling_pathway 4 68 2.353e-06 1.694e-05
26 hsa04720_Long.term_potentiation 4 70 2.644e-06 1.83e-05
27 hsa04070_Phosphatidylinositol_signaling_system 4 78 4.081e-06 2.721e-05
28 hsa04810_Regulation_of_actin_cytoskeleton 5 214 1.076e-05 6.92e-05
29 hsa04670_Leukocyte_transendothelial_migration 4 117 2.043e-05 0.0001268
30 hsa03013_RNA_transport 4 152 5.696e-05 0.0003418
31 hsa04730_Long.term_depression 2 70 0.004304 0.02499
32 hsa04350_TGF.beta_signaling_pathway 2 85 0.00628 0.03533
33 hsa04530_Tight_junction 2 133 0.01482 0.08082

Quest ID: 0d1d92d957b4fc66dea3b9c17e0fcf0f