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This regulatory network was inferred from the input dataset. The miRNAs and mRNAs are presented as round and rectangle nodes respectively. The numerical value popped up upon mouse over the gene node is the log2 transformed fold-change of the gene expression between the two groups. All of the nodes are clickable, and the detailed information of the miRNAs/mRNAs and related cancer pathway will be displayed in another window. The edges between nodes are supported by both interactions (predicted or experimentally verified) and correlations learnt from cancer dataset. The numerical value popped up upon mouse over the edge is the correlation beat value (effect size) between the two nodes. The experimental evidences of the edges reported in previous cancer studies are highlighted by red/orange color. All of these information can be accessed by the "mouse-over" action. This network shows a full map of the miRNA-mRNA regulation of the input gene list(s), and the hub miRNAs (with the high network degree/betweenness centrality) would be the potential cancer drivers or tumor suppressors. The full result table can be accessed in the "Regulations" tab.

"miRNACancerMAP" is also a network visualization tool for users to draw their regulatory network by personal customization. Users can set the complexity of the network by limiting the number of nodes or edges. And the color of the nodes can be defined by different categories of the mRNAs and miRNAs, such as Gene-Ontology, pathway, and expression status. Users can also select to use network degree or network betweenness centrality to define the node size. And edges can be black or colored by the correlation. Purple edge means negative correlation (mostly found between miRNA and mRNA), and blue edge means positive correlation (found in PPI or miRNA-miRNA sponge effect). We can also add the protein-protein interactions (PPI) into the network. This result will show the cluster of genes regulated by some specific miRNAs. Additionally, miRNA-miRNA edges can be added by the "miRNA sponge" button, presenting some clusters of miRNAs that have the interactions via sponge effect.

miRNA-gene regulations

(Download full result)

Num microRNA           Gene miRNA log2FC miRNA pvalue Gene log2FC Gene pvalue Interaction Correlation beta Correlation P-value PMID Reported in cancer studies
1 hsa-miR-182-5p CAMK2B -0.1 0.97338 2.17 0.00982 mirMAP -0.23 0.04992 NA
2 hsa-miR-186-5p CAMK2B -0.32 0.85413 2.17 0.00982 miRNAWalker2 validate; miRNATAP -0.92 0 NA
3 hsa-miR-18a-5p CAMK2B -0.5 0.61264 2.17 0.00982 mirMAP -0.33 0.00078 NA
4 hsa-miR-18b-5p CAMK2B -0.05 0.89998 2.17 0.00982 mirMAP -0.21 0.03116 NA
5 hsa-miR-335-5p CAMK2B -0.03 0.97338 2.17 0.00982 mirMAP -0.3 0.01498 NA
6 hsa-miR-34a-5p CAMK2B -0.5 0.74203 2.17 0.00982 mirMAP -0.28 0.04878 NA
7 hsa-miR-362-3p CAMK2B -0.72 0.03459 2.17 0.00982 miRanda -0.39 0.00026 NA
8 hsa-miR-362-5p CAMK2B -0.27 0.75202 2.17 0.00982 miRNATAP -0.43 3.0E-5 NA
9 hsa-miR-377-3p CAMK2B -0.04 0.89351 2.17 0.00982 mirMAP -0.3 0.01013 NA
10 hsa-miR-491-5p CAMK2B -0.59 0.04526 2.17 0.00982 miRanda -0.24 0.04944 NA
11 hsa-miR-577 CAMK2B -1.06 0.32606 2.17 0.00982 miRNATAP -0.33 0 NA
12 hsa-miR-589-3p CAMK2B -0.84 0.0112 2.17 0.00982 MirTarget -0.47 0 NA
13 hsa-miR-590-3p CAMK2B -0.28 0.59127 2.17 0.00982 miRanda -0.42 0.00016 NA
14 hsa-miR-625-5p CAMK2B -0.69 0.21031 2.17 0.00982 mirMAP -0.4 3.0E-5 NA
15 hsa-miR-628-5p CAMK2B -0.51 0.35193 2.17 0.00982 miRNATAP -0.53 0.00189 NA
16 hsa-miR-940 CAMK2B -0.23 0.68006 2.17 0.00982 PITA; miRNATAP -0.25 0.0094 NA
17 hsa-miR-96-5p CAMK2B 0.09 0.92309 2.17 0.00982 mirMAP -0.29 0.01248 NA
18 hsa-miR-335-5p CST6 -0.03 0.97338 2.04 0.00979 miRNAWalker2 validate -0.49 0.00072 NA
19 hsa-miR-1301-3p DPP10 -0.3 0.59226 2.83 0.00684 MirTarget -0.56 0.0119 NA
20 hsa-miR-16-2-3p DPP10 -0.37 0.54685 2.83 0.00684 MirTarget -0.85 1.0E-5 NA
21 hsa-miR-18a-3p DPP10 -0.27 0.53529 2.83 0.00684 MirTarget -0.41 0.00837 NA
22 hsa-miR-18a-5p DPP10 -0.5 0.61264 2.83 0.00684 miRNATAP -0.38 0.015 NA
23 hsa-miR-25-3p DPP10 -0.46 0.87857 2.83 0.00684 MirTarget; miRNATAP -1.05 0.00049 NA
24 hsa-miR-26a-2-3p DPP10 -0.43 0.28777 2.83 0.00684 mirMAP -0.47 0.0164 NA
25 hsa-miR-32-5p DPP10 -0.06 0.95298 2.83 0.00684 MirTarget; miRNATAP -0.47 0.02543 NA
26 hsa-miR-330-3p DPP10 0 0.9945 2.83 0.00684 PITA -0.49 0.03607 NA
27 hsa-miR-33a-3p DPP10 -0.79 0.01052 2.83 0.00684 mirMAP -0.45 0.01325 NA
28 hsa-miR-33b-5p DPP10 -0.16 0.73744 2.83 0.00684 miRNATAP -0.28 0.02791 NA
29 hsa-miR-362-3p DPP10 -0.72 0.03459 2.83 0.00684 miRanda -0.46 0.00855 NA
30 hsa-miR-421 DPP10 -0.18 0.7347 2.83 0.00684 miRanda -0.45 0.02909 NA
31 hsa-miR-429 DPP10 -0.46 0.80624 2.83 0.00684 miRanda -0.5 0.00343 NA
32 hsa-miR-505-3p DPP10 -0.47 0.69038 2.83 0.00684 mirMAP -1.12 1.0E-5 NA
33 hsa-miR-576-5p DPP10 -0.51 0.41719 2.83 0.00684 PITA -1.03 0 NA
34 hsa-miR-577 DPP10 -1.06 0.32606 2.83 0.00684 MirTarget; mirMAP; miRNATAP -0.5 0 NA
35 hsa-miR-582-3p DPP10 -0.23 0.89768 2.83 0.00684 miRNATAP -0.81 0.00027 NA
36 hsa-miR-589-3p DPP10 -0.84 0.0112 2.83 0.00684 MirTarget -0.56 0.0008 NA
37 hsa-miR-590-3p DPP10 -0.28 0.59127 2.83 0.00684 miRanda -0.79 1.0E-5 NA
38 hsa-miR-590-5p DPP10 -0.55 0.47274 2.83 0.00684 miRanda -0.74 8.0E-5 NA
39 hsa-miR-92b-3p DPP10 -0.57 0.68932 2.83 0.00684 MirTarget; miRNATAP -1.12 0 NA
40 hsa-miR-146b-5p ELF5 -0.4 0.83751 3.01 0.00569 miRanda -1.03 0.00077 NA
41 hsa-miR-22-3p ELF5 0.06 0.98656 3.01 0.00569 MirTarget; miRNATAP -1.2 0.01041 NA
42 hsa-miR-338-3p ELF5 0.49 0.78848 3.01 0.00569 miRanda -0.62 0.00195 NA
43 hsa-miR-486-5p ELF5 -0.55 0.6964 3.01 0.00569 miRanda -0.46 0.01132 NA
44 hsa-miR-582-5p ELF5 -0.4 0.58123 3.01 0.00569 miRNATAP -1.13 0.0001 NA
45 hsa-miR-590-3p ELF5 -0.28 0.59127 3.01 0.00569 miRanda; mirMAP -0.47 0.03694 NA
46 hsa-miR-590-3p FGF19 -0.28 0.59127 2.94 0.00049 miRanda -0.57 0.00178 NA
47 hsa-let-7a-3p FREM2 -0.22 0.85543 2.56 0.00368 MirTarget; mirMAP -0.52 0.0458 NA
48 hsa-let-7a-5p FREM2 -0.06 0.98501 2.56 0.00368 TargetScan -1.46 0.00064 NA
49 hsa-let-7i-5p FREM2 -0.2 0.92202 2.56 0.00368 miRNATAP -1.92 1.0E-5 NA
50 hsa-miR-107 FREM2 -0.04 0.98836 2.56 0.00368 miRanda -1.53 0.00011 NA
51 hsa-miR-130b-5p FREM2 -0.65 0.3791 2.56 0.00368 MirTarget -0.58 0.01191 NA
52 hsa-miR-142-5p FREM2 -0.12 0.92967 2.56 0.00368 MirTarget -0.83 9.0E-5 NA
53 hsa-miR-15b-3p FREM2 -0.56 0.60918 2.56 0.00368 mirMAP -0.75 0.00187 NA
54 hsa-miR-21-5p FREM2 -0.15 0.97024 2.56 0.00368 mirMAP -1.62 4.0E-5 NA
55 hsa-miR-2110 FREM2 -0.32 0.25098 2.56 0.00368 MirTarget -0.54 0.01957 NA
56 hsa-miR-29b-1-5p FREM2 -0.64 0.29389 2.56 0.00368 mirMAP -0.42 0.01319 NA
57 hsa-miR-576-5p FREM2 -0.51 0.41719 2.56 0.00368 mirMAP -1.04 1.0E-5 NA
58 hsa-miR-577 FREM2 -1.06 0.32606 2.56 0.00368 mirMAP -0.43 0.00042 NA
59 hsa-miR-590-3p FREM2 -0.28 0.59127 2.56 0.00368 miRanda; mirMAP -0.8 5.0E-5 NA
60 hsa-miR-590-5p FREM2 -0.55 0.47274 2.56 0.00368 miRanda; mirMAP -0.71 0.0006 NA
61 hsa-miR-760 FREM2 -0.67 0.07735 2.56 0.00368 miRNATAP -0.37 0.02409 NA
62 hsa-miR-155-5p GABRB2 -0.41 0.82867 2.16 0.00776 mirMAP -0.58 0.003 NA
63 hsa-miR-186-5p GABRB2 -0.32 0.85413 2.16 0.00776 mirMAP -0.87 0.00184 NA
64 hsa-miR-25-3p GABRB2 -0.46 0.87857 2.16 0.00776 mirMAP -0.84 0.00258 NA
65 hsa-miR-29a-5p GABRB2 -0.32 0.60044 2.16 0.00776 mirMAP -0.38 0.03585 NA
66 hsa-miR-33a-3p GABRB2 -0.79 0.01052 2.16 0.00776 mirMAP -0.4 0.01741 NA
67 hsa-miR-362-3p GABRB2 -0.72 0.03459 2.16 0.00776 miRanda -0.37 0.02208 NA
68 hsa-miR-374a-3p GABRB2 -0.12 0.95818 2.16 0.00776 mirMAP -0.51 0.01096 NA
69 hsa-miR-501-5p GABRB2 -0.83 0.05827 2.16 0.00776 mirMAP -0.41 0.0058 NA
70 hsa-miR-502-5p GABRB2 -0.71 0.02613 2.16 0.00776 PITA -0.52 0.00141 NA
71 hsa-miR-577 GABRB2 -1.06 0.32606 2.16 0.00776 mirMAP -0.43 3.0E-5 NA
72 hsa-miR-582-3p GABRB2 -0.23 0.89768 2.16 0.00776 PITA -0.71 0.00061 NA
73 hsa-miR-582-5p GABRB2 -0.4 0.58123 2.16 0.00776 PITA -0.74 0.00052 NA
74 hsa-miR-584-5p GABRB2 -0.22 0.90686 2.16 0.00776 mirMAP -0.54 3.0E-5 NA
75 hsa-miR-590-3p GABRB2 -0.28 0.59127 2.16 0.00776 PITA; miRanda; mirMAP -0.65 7.0E-5 NA
76 hsa-miR-590-5p GABRB2 -0.55 0.47274 2.16 0.00776 PITA; miRanda -0.7 6.0E-5 NA
77 hsa-miR-7-1-3p GABRB2 -0.46 0.6659 2.16 0.00776 mirMAP -0.49 0.01169 NA
78 hsa-miR-128-3p NPTX2 -0.44 0.78389 2.25 0.00809 MirTarget -0.57 0.01302 NA
79 hsa-miR-194-3p NPTX2 -0.61 0.73321 2.25 0.00809 miRNATAP -0.34 0.02138 NA
80 hsa-miR-320a NPTX2 -0.42 0.8402 2.25 0.00809 PITA; miRanda -0.8 0.00014 NA
81 hsa-miR-320b NPTX2 -0.24 0.85922 2.25 0.00809 PITA; miRanda -0.7 0.00022 NA
82 hsa-miR-320c NPTX2 -0.58 0.1136 2.25 0.00809 PITA; miRanda -0.34 0.01502 NA
83 hsa-miR-330-3p NPTX2 0 0.9945 2.25 0.00809 MirTarget; miRNATAP -0.43 0.02769 NA
84 hsa-miR-330-5p NPTX2 -0.28 0.81569 2.25 0.00809 miRanda -0.8 0.00054 NA
85 hsa-miR-429 NPTX2 -0.46 0.80624 2.25 0.00809 miRNATAP -0.38 0.00711 NA
86 hsa-miR-590-3p NPTX2 -0.28 0.59127 2.25 0.00809 miRanda -0.5 0.00066 NA
87 hsa-miR-96-5p NPTX2 0.09 0.92309 2.25 0.00809 MirTarget; TargetScan; miRNATAP -0.3 0.04873 NA
88 hsa-miR-31-5p PCSK1N 0.55 0.45274 2.38 0.0054 miRNAWalker2 validate -0.34 0.00021 NA
89 hsa-miR-141-3p SCEL -0.32 0.87774 2.83 0.00138 TargetScan -0.39 0.0402 NA
90 hsa-miR-320a SCEL -0.42 0.8402 2.83 0.00138 miRanda -0.6 0.02648 NA
91 hsa-miR-577 SCEL -1.06 0.32606 2.83 0.00138 MirTarget; PITA -0.33 0.00533 NA
92 hsa-miR-590-3p SCEL -0.28 0.59127 2.83 0.00138 miRanda -0.59 0.00178 NA
93 hsa-miR-92b-3p SLC15A1 -0.57 0.68932 2.83 0.00103 miRNAWalker2 validate; miRTarBase -0.72 0.00131 NA
94 hsa-miR-140-3p WIF1 -0.37 0.86476 3.12 0.00672 PITA; miRNATAP -1.21 0.00962 NA
95 hsa-miR-320a WIF1 -0.42 0.8402 3.12 0.00672 miRanda -0.63 0.04732 NA
96 hsa-miR-320b WIF1 -0.24 0.85922 3.12 0.00672 miRanda -0.63 0.02839 NA
97 hsa-miR-330-5p WIF1 -0.28 0.81569 3.12 0.00672 miRanda -1.06 0.00243 NA
98 hsa-miR-342-3p WIF1 -0.37 0.77314 3.12 0.00672 miRanda -0.54 0.04668 NA
99 hsa-miR-590-3p WIF1 -0.28 0.59127 3.12 0.00672 PITA; miRanda; mirMAP -0.47 0.03603 NA

Over-represented Gene Ontology Biological Process

NumGOOverlapSizeP ValueAdj. P Value
NumGOOverlapSizeP ValueAdj. P Value
NumGOOverlapSizeP ValueAdj. P Value

Over-represented Pathway

NumPathwayPathviewOverlapSizeP ValueAdj. P Value
1 hsa04310_Wnt_signaling_pathway 2 151 0.003556 0.6401

lncRNA-mediated sponge

(Download full result)

Num lncRNA miRNAs           miRNAs count     Gene Sponge regulatory network lncRNA log2FC lncRNA pvalue Gene log2FC Gene pvalue lncRNA-gene Pearson correlation
1

EMX2OS

 hsa-miR-182-5p;hsa-miR-186-5p;hsa-miR-18a-5p;hsa-miR-18b-5p;hsa-miR-335-5p;hsa-miR-34a-5p;hsa-miR-362-3p;hsa-miR-577;hsa-miR-589-3p;hsa-miR-590-3p;hsa-miR-625-5p;hsa-miR-940 12 CAMK2B Sponge network 1.057 0.31716 2.17 0.00982 0.338
2

CECR7

 hsa-miR-182-5p;hsa-miR-186-5p;hsa-miR-18a-5p;hsa-miR-18b-5p;hsa-miR-335-5p;hsa-miR-362-3p;hsa-miR-362-5p;hsa-miR-491-5p;hsa-miR-589-3p;hsa-miR-590-3p;hsa-miR-625-5p;hsa-miR-940 12 CAMK2B Sponge network 0.551 0.56177 2.17 0.00982 0.298

Quest ID: acef23e0fb249ebfe605eca140a48447