This regulatory network was inferred from the input dataset. The miRNAs and mRNAs are
presented as round and rectangle nodes respectively. The numerical value popped up upon mouse over the gene node is the log2 transformed fold-change of the gene expression between the two groups. All of the nodes are clickable, and the detailed information of the miRNAs/mRNAs and related cancer pathway will be displayed in another window. The edges between nodes are supported by both interactions (predicted or experimentally verified) and correlations learnt from cancer dataset. The numerical value popped up upon mouse over the edge is the correlation beat value (effect size) between the two nodes. The experimental evidences of the edges reported in previous cancer studies are highlighted by red/orange color. All of these information can be accessed by the "mouse-over" action. This network shows a full map of the miRNA-mRNA regulation of the input gene list(s), and the hub miRNAs (with the high network degree/betweenness centrality) would be the potential cancer drivers or tumor suppressors. The full result table can be accessed in the "Regulations" tab.
"miRNACancerMAP" is also a network visualization tool for users to draw their regulatory network by personal customization. Users can set the complexity of the network by limiting the number of nodes or edges. And the color of the nodes can be defined by different categories of the mRNAs and miRNAs, such as Gene-Ontology, pathway, and expression status. Users can also select to use network degree or network betweenness centrality to define the node size. And edges can be black or colored by the correlation. Purple edge means negative correlation (mostly found between miRNA and mRNA), and blue edge means positive correlation (found in PPI or miRNA-miRNA sponge effect). We can also add the protein-protein interactions (PPI) into the network. This result will show the cluster of genes regulated by some specific miRNAs. Additionally, miRNA-miRNA edges can be added by the "miRNA sponge" button, presenting some clusters of miRNAs that have the interactions via sponge effect.
| Num | microRNA | Gene | miRNA log2FC | miRNA pvalue | Gene log2FC | Gene pvalue | Interaction | Correlation beta | Correlation P-value | PMID | Reported in cancer studies |
|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | hsa-miR-106b-5p | PTEN | -0.53 | 0.63002 | 0.21 | 0.81308 | miRNAWalker2 validate; miRTarBase; miRNATAP | -0.16 | 0 | 24842611; 24842611 | MicroRNA-106b in cancer-associated fibroblasts from gastric cancer promotes cell migration and invasion by targeting PTEN;Here we have shown that miR-106b is up-regulated in cancer associated fibroblasts compared with normal fibroblasts established from patients with gastric cancer the expression level of miR-106b is associated with poor prognosis of patients and CAFs with down-regulated miR-106b could significantly inhibit gastric cancer cell migration and invasion by targeting PTEN |
| 2 | hsa-miR-141-3p | PTEN | -0.98 | 0.46856 | 0.21 | 0.81308 | miRNAWalker2 validate; miRTarBase; TargetScan; miRNATAP | -0.09 | 0 | 24742567; 24742567 | 3 In typeIEC loss of PTEN was more frequent in the miR-141 or miR-200a up-regulated subgroups and the correlation between the PTEN and miR-200a status in typeItumors was statistically significant P < 0.05;PTEN might be a potential target of miR-141 and miR-200a in endometrial carcinogenesis |
| 3 | hsa-miR-144-3p | PTEN | -1.1 | 0.02007 | 0.21 | 0.81308 | miRNAWalker2 validate; miRNATAP | -0.05 | 0.00532 | ||
| 4 | hsa-miR-17-5p | PTEN | -0.56 | 0.64971 | 0.21 | 0.81308 | miRNAWalker2 validate; miRTarBase; TargetScan; miRNATAP | -0.11 | 3.0E-5 | 23418359; 25617127; 24912422; 24912422; 24912422; 24912422; 23391506 | The mature miR-17-5p exerted this function by repressing the expression of PTEN;The overexpressed PTENP1 decoyed oncomirs miR-17 miR-19b and miR-20a which would otherwise target PTEN PHLPP a negative AKT regulator and such autophagy genes as ULK1 ATG7 and p62 indicating that PTENP1 modulated the HCC cell behavior and gene networks by miRNA regulation;MicroRNA-17-5p promotes chemotherapeutic drug resistance and tumour metastasis of colorectal cancer by repressing PTEN expression;We found that PTEN was a target of miR-17-5p in the colon cancer cells and their context-specific interactions were responsible for multiple drug-resistance;Chemotherapy was found to increase the expression levels of miR-17-5p which further repressed PTEN levels contributing to the development of chemo-resistance;MiR-17-5p is a predictive factor for chemotherapy response and a prognostic factor for overall survival in CRC which is due to its regulation of PTEN expression;Stress response of glioblastoma cells mediated by miR-17-5p targeting PTEN and the passenger strand miR-17-3p targeting MDM2 |
| 5 | hsa-miR-18a-5p | PTEN | -0.32 | 0.63016 | 0.21 | 0.81308 | miRNAWalker2 validate; miRTarBase | -0.1 | 0 | ||
| 6 | hsa-miR-193b-3p | PTEN | -0.03 | 0.974 | 0.21 | 0.81308 | miRNAWalker2 validate; miRNATAP | -0.08 | 0.00948 | ||
| 7 | hsa-miR-19a-3p | PTEN | -0.28 | 0.68677 | 0.21 | 0.81308 | miRNAWalker2 validate; miRTarBase; MirTarget; miRNATAP | -0.1 | 5.0E-5 | 25107371; 25107371; 24831732 | The target of miR-19a was identified by western blot and whether its regulatory role depends on its target was improved by a rescue experiment with miR-19a mimic and PTEN expression plasmid;Meanwhile gain or loss of function of miR-19a demonstrated that miR-19a can promote cell growth of bladder cancer cells and the further mechanism studies indicated that its oncogenic role was dependent on targeting PTEN;Meanwhile BPA-induced upregulation of oncogenic miR-19a and miR-19b and the dysregulated expression of miR-19-related downstream proteins including PTEN p-AKT p-MDM2 p53 and proliferating cell nuclear antigen were reversed by curcumin |
| 8 | hsa-miR-19b-3p | PTEN | -0.48 | 0.62971 | 0.21 | 0.81308 | miRNAWalker2 validate; miRTarBase; MirTarget; miRNATAP | -0.13 | 1.0E-5 | ||
| 9 | hsa-miR-20a-5p | PTEN | -0.37 | 0.74576 | 0.21 | 0.81308 | miRNAWalker2 validate; miRTarBase; miRNATAP | -0.06 | 0.02122 | ||
| 10 | hsa-miR-221-3p | PTEN | -0.13 | 0.90846 | 0.21 | 0.81308 | miRNAWalker2 validate; miRTarBase | -0.07 | 0.01589 | 20618998; 20618998; 20618998; 20618998; 20618998 | MicroRNA-221 and microRNA-222 regulate gastric carcinoma cell proliferation and radioresistance by targeting PTEN;Upregulation of miR-221 and miR-222 induced the malignant phenotype of SGC7901 cells whereas knockdown of miR-221 and miR-222 reversed this phenotype via induction of PTEN expression;Notably the seed sequence of miR-221 and miR-222 matched the 3'UTR of PTEN and introducing a PTEN cDNA without the 3'UTR into SGC7901 cells abrogated the miR-221 and miR-222-induced malignant phenotype;PTEN-3'UTR luciferase reporter assay confirmed PTEN as a direct target of miR-221 and miR-222;These results demonstrate that miR-221 and miR-222 regulate radiosensitivity and cell growth and invasion of SGC7901 cells possibly via direct modulation of PTEN expression |
| 11 | hsa-miR-222-3p | PTEN | -0.28 | 0.76414 | 0.21 | 0.81308 | miRNAWalker2 validate; miRTarBase | -0.09 | 0.00039 | 20618998; 20618998; 20618998; 20618998; 20618998 | MicroRNA-221 and microRNA-222 regulate gastric carcinoma cell proliferation and radioresistance by targeting PTEN;Upregulation of miR-221 and miR-222 induced the malignant phenotype of SGC7901 cells whereas knockdown of miR-221 and miR-222 reversed this phenotype via induction of PTEN expression;Notably the seed sequence of miR-221 and miR-222 matched the 3'UTR of PTEN and introducing a PTEN cDNA without the 3'UTR into SGC7901 cells abrogated the miR-221 and miR-222-induced malignant phenotype;PTEN-3'UTR luciferase reporter assay confirmed PTEN as a direct target of miR-221 and miR-222;These results demonstrate that miR-221 and miR-222 regulate radiosensitivity and cell growth and invasion of SGC7901 cells possibly via direct modulation of PTEN expression |
| 12 | hsa-miR-29b-3p | PTEN | -0.15 | 0.91451 | 0.21 | 0.81308 | miRNAWalker2 validate; miRTarBase; MirTarget; miRNATAP | -0.07 | 0.036 | ||
| 13 | hsa-miR-93-5p | PTEN | -0.42 | 0.80151 | 0.21 | 0.81308 | miRNAWalker2 validate; miRTarBase; miRNATAP | -0.07 | 0.01927 | 22465665 | MiR-93 inversely correlates with PTEN expression in CDDP-resistant and sensitive human ovarian cancer tissues |
| 14 | hsa-miR-25-3p | PTEN | -0.41 | 0.82274 | 0.21 | 0.81308 | miRTarBase; MirTarget; miRNATAP | -0.18 | 0 | ||
| 15 | hsa-miR-130a-3p | PTEN | 0.91 | 0.27054 | 0.21 | 0.81308 | MirTarget; miRNATAP | -0.1 | 0.00171 | 24490491; 24490491 | Down-regulated miR-130a did not affect cell proliferations but enhanced the sensitivity of the cells to cisplatin inhibited the expressions of MDR1 mRNA and P-gp and increased the expression of PTEN proteins;MiR-130a inhibitor can reverse the cisplatin resistance by upregulating the expression of PTEN proteins and down-regulating P-gp in A2780 cell lines |
| 16 | hsa-miR-130b-3p | PTEN | -0.67 | 0.25044 | 0.21 | 0.81308 | MirTarget; miRNATAP | -0.13 | 0 | ||
| 17 | hsa-miR-142-5p | PTEN | 0.19 | 0.83516 | 0.21 | 0.81308 | MirTarget; PITA | -0.07 | 0.0011 | ||
| 18 | hsa-miR-148a-3p | PTEN | -0.54 | 0.80349 | 0.21 | 0.81308 | MirTarget; miRNATAP | -0.15 | 0 | ||
| 19 | hsa-miR-148b-3p | PTEN | -0.2 | 0.83765 | 0.21 | 0.81308 | MirTarget; miRNATAP | -0.19 | 0 | ||
| 20 | hsa-miR-16-1-3p | PTEN | -0.22 | 0.53402 | 0.21 | 0.81308 | MirTarget | -0.09 | 0.00258 | ||
| 21 | hsa-miR-188-5p | PTEN | -0.67 | 0.07038 | 0.21 | 0.81308 | MirTarget; PITA; miRNATAP | -0.11 | 0 | ||
| 22 | hsa-miR-26b-5p | PTEN | -0.32 | 0.8095 | 0.21 | 0.81308 | MirTarget; miRNATAP | -0.13 | 0.00011 | ||
| 23 | hsa-miR-301a-3p | PTEN | -0.14 | 0.73337 | 0.21 | 0.81308 | MirTarget; miRNATAP | -0.12 | 4.0E-5 | ||
| 24 | hsa-miR-3065-3p | PTEN | -0.34 | 0.58998 | 0.21 | 0.81308 | MirTarget; miRNATAP | -0.05 | 0.03654 | ||
| 25 | hsa-miR-30d-3p | PTEN | -0.63 | 0.0725 | 0.21 | 0.81308 | MirTarget; miRNATAP | -0.08 | 0.04264 | ||
| 26 | hsa-miR-32-5p | PTEN | -0.5 | 0.485 | 0.21 | 0.81308 | MirTarget; miRNATAP | -0.15 | 0 | 23617834; 23617834; 23617834; 23617834; 23617834; 23617834; 24123284; 24123284; 24123284; 24123284; 24123284; 24123284; 25647261; 25647261; 25647261; 25647261 | MicroRNA-32 miR-32 regulates phosphatase and tensin homologue PTEN expression and promotes growth migration and invasion in colorectal carcinoma cells;The effect of miR-32 on PTEN expression was assessed in CRC cell lines with miR-32 mimics/inhibitor to increase/decrease miR-32 expression;Gain-of-function and loss-of-function studies showed that overexpression of miR-32 promoted SW480 cell proliferation migration and invasion reduced apoptosis and resulted in downregulation of PTEN at a posttranscriptional level;However miR-32 knock-down inhibited these processes in HCT-116 cells and enhanced the expression of PTEN protein;In addition we further identified PTEN as the functional downstream target of miR-32 by directly targeting the 3'-UTR of PTEN;Our results demonstrated that miR-32 was involved in tumorigenesis of CRC at least in part by suppression of PTEN;In this study we determined the levels of the correlation between and the clinical significance of the expression of miR-32 and phosphatase and tensin homologue PTEN a tumor suppressor targeted by miR-32 in CRC;The levels of miR-32 and PTEN gene expression in 35 colorectal carcinoma samples 35 corresponding cancer-adjacent tissue samples 27 colorectal adenoma samples and 16 normal tissue samples were quantified using real-time quantitative reverse transcriptase-polymerase chain reaction;The relationship between the miR-32 and PTEN protein expression and clinicopathological factors was analyzed;Significant upregulation of miR-32 expression and reduction of PTEN were identified in CRC tissues;An inverse relationship between miR-32 and PTEN protein expression was identified;MiR-32 and PTEN expression were inversely correlated and miR-32 may be associated with the development of CRC;MiR-32 induces cell proliferation migration and invasion in hepatocellular carcinoma by targeting PTEN;In the present study we found the expression of miR-32 was up-regulated in HCC tissue and cell lines inversely the expression of phosphatase and tensin homolog PTEN decreased;Besides miRNA-32 down-regulates PTEN through binding to 3'-UTR of PTEN mRNA from luciferase reporter assay and the expression level of miR-32 could affect the proliferation migration and invasion of liver cancer cell lines via PTEN/Akt signaling pathway;Down-expression of PTEN could significantly attenuate the inhibitory effects of knockdown miR-32 on the proliferation migration and invasion of liver cancer cells suggesting that miR-32 could be a potential target for HCC treatment |
| 27 | hsa-miR-320a | PTEN | -0.6 | 0.64785 | 0.21 | 0.81308 | MirTarget; PITA; miRanda; miRNATAP | -0.09 | 0.01426 | ||
| 28 | hsa-miR-320b | PTEN | -0.69 | 0.11662 | 0.21 | 0.81308 | MirTarget; PITA; miRanda; miRNATAP | -0.12 | 0 | ||
| 29 | hsa-miR-335-3p | PTEN | -0.17 | 0.84307 | 0.21 | 0.81308 | MirTarget | -0.08 | 0.0003 | ||
| 30 | hsa-miR-337-3p | PTEN | 0.35 | 0.60852 | 0.21 | 0.81308 | MirTarget; PITA; miRNATAP | -0.1 | 0.00104 | ||
| 31 | hsa-miR-374a-5p | PTEN | -0.07 | 0.92685 | 0.21 | 0.81308 | MirTarget; mirMAP | -0.13 | 0.04507 | ||
| 32 | hsa-miR-374b-5p | PTEN | -0.03 | 0.9734 | 0.21 | 0.81308 | MirTarget; mirMAP; miRNATAP | -0.16 | 0.00117 | ||
| 33 | hsa-miR-454-3p | PTEN | -0.3 | 0.47036 | 0.21 | 0.81308 | MirTarget; miRNATAP | -0.15 | 1.0E-5 | ||
| 34 | hsa-miR-495-3p | PTEN | 0.22 | 0.62985 | 0.21 | 0.81308 | MirTarget; mirMAP | -0.08 | 0.01744 | ||
| 35 | hsa-miR-589-3p | PTEN | -0.42 | 0.15067 | 0.21 | 0.81308 | MirTarget; mirMAP | -0.08 | 0.00195 | ||
| 36 | hsa-miR-590-3p | PTEN | -0.43 | 0.27045 | 0.21 | 0.81308 | MirTarget; PITA; miRanda; mirMAP | -0.15 | 0 | 23803188; 23803188 | miR-590-3p was found to activate PI3K-AKT signaling pathway by down-regulating PTEN to promote AKT1-S473 phosphorylation;MiR-590 is an important tumorigenic factor for HCC and its two arms can both promote tumorigenesis by regulating the expression of their target tumor suppressor gene PDCD4 and PTEN to promote HCC cell proliferation and survival and activate the core tumor signal pathway PI3K-AKT |
| 37 | hsa-miR-92a-3p | PTEN | -0.51 | 0.78229 | 0.21 | 0.81308 | MirTarget; miRNATAP | -0.14 | 1.0E-5 | ||
| 38 | hsa-miR-92b-3p | PTEN | -0.14 | 0.8803 | 0.21 | 0.81308 | MirTarget; miRNATAP | -0.14 | 9.0E-5 | 24099768 | Furthermore we found miR-92b could directly target PTEN a unique tumor suppressor gene which was downregulated in lung cancer tissues compared to the matched adjacent normal tissues |
| 39 | hsa-miR-193a-3p | PTEN | 0.13 | 0.77577 | 0.21 | 0.81308 | PITA; miRanda | -0.11 | 0.00316 | ||
| 40 | hsa-miR-429 | PTEN | -1.24 | 0.27606 | 0.21 | 0.81308 | PITA; miRanda; mirMAP; miRNATAP | -0.08 | 0 | 24866238 | Furthermore we demonstrated that miR-429 down-regulates PTEN RASSF8 and TIMP2 expression by directly targeting the 3'-untranslated region of these target genes |
| 41 | hsa-miR-532-5p | PTEN | -0.51 | 0.7124 | 0.21 | 0.81308 | PITA; mirMAP; miRNATAP | -0.09 | 0.00697 | ||
| 42 | hsa-miR-542-3p | PTEN | -0.01 | 0.99534 | 0.21 | 0.81308 | PITA; miRanda; miRNATAP | -0.09 | 0.02151 | ||
| 43 | hsa-miR-577 | PTEN | -1.08 | 0.11826 | 0.21 | 0.81308 | PITA; mirMAP; miRNATAP | -0.06 | 1.0E-5 | ||
| 44 | hsa-miR-200b-3p | PTEN | -1.05 | 0.47475 | 0.21 | 0.81308 | TargetScan; mirMAP | -0.07 | 0.00015 | ||
| 45 | hsa-miR-125a-3p | PTEN | -0.04 | 0.89146 | 0.21 | 0.81308 | miRanda | -0.09 | 0.00523 | ||
| 46 | hsa-miR-362-3p | PTEN | -0.55 | 0.09533 | 0.21 | 0.81308 | miRanda | -0.06 | 0.01679 | ||
| 47 | hsa-miR-342-3p | PTEN | 0.67 | 0.47376 | 0.21 | 0.81308 | miRanda | -0.08 | 0.00828 | ||
| 48 | hsa-miR-455-5p | PTEN | -0.32 | 0.65136 | 0.21 | 0.81308 | miRanda | -0.08 | 0.01129 | ||
| 49 | hsa-miR-421 | PTEN | -0.45 | 0.08409 | 0.21 | 0.81308 | miRanda | -0.1 | 0.00017 | ||
| 50 | hsa-let-7a-3p | PTEN | -0.34 | 0.64143 | 0.21 | 0.81308 | mirMAP | -0.15 | 2.0E-5 | ||
| 51 | hsa-let-7b-3p | PTEN | -0.37 | 0.56889 | 0.21 | 0.81308 | mirMAP | -0.14 | 0.00298 | ||
| 52 | hsa-let-7f-1-3p | PTEN | -0.36 | 0.2428 | 0.21 | 0.81308 | mirMAP | -0.11 | 0.00208 | ||
| 53 | hsa-miR-136-5p | PTEN | 0.56 | 0.38172 | 0.21 | 0.81308 | mirMAP | -0.08 | 0.00442 | ||
| 54 | hsa-miR-15b-3p | PTEN | -0.89 | 0.22123 | 0.21 | 0.81308 | mirMAP | -0.14 | 0 | ||
| 55 | hsa-miR-16-2-3p | PTEN | -0.55 | 0.25958 | 0.21 | 0.81308 | mirMAP | -0.12 | 0 | ||
| 56 | hsa-miR-182-5p | PTEN | -1.16 | 0.52182 | 0.21 | 0.81308 | mirMAP | -0.09 | 2.0E-5 | ||
| 57 | hsa-miR-186-5p | PTEN | -0.3 | 0.7872 | 0.21 | 0.81308 | mirMAP; miRNATAP | -0.21 | 0 | ||
| 58 | hsa-miR-200c-3p | PTEN | -1.06 | 0.55838 | 0.21 | 0.81308 | mirMAP; miRNATAP | -0.09 | 0 | 23869765; 24682933; 24682933; 20716115; 22637745; 22637745 | Moreover transfection of miR-20a or miR-200c led to corresponding reduction in endogenous PTEN protein while AKT1 and phosphate AKT1 levels were upregulated in miRNAs-transfected cells;The effects of silencing miR-200c expression were associated with upregulation of PTEN protein and p53 Ser15 phosphorylation levels in HCT-116 cells and PTEN protein expression in HT-29 cells;In conclusion miR-200c functions as an oncogene in colon cancer cells through regulating tumor cell apoptosis survival invasion and metastasis as well as xenograft tumor growth through inhibition of PTEN expression and p53 phosphorylation;Expression of zinc finger E-box binding homeobox ZEB1 and c-Myc targets of miR-200c as well as of p21 protein Cdc42/Rac-activated kinase PAK1 and phosphatase and tensin homologue deleted on chromosome 10 PTEN predicted targets of miR-222 were analysed;Forced over-expression or silencing of miR-200c followed by either CDF or BR-DIM treatment of MIAPaCa-2 cells altered the morphology of cells wound-healing capacity colony formation and the expression of MT1-MMP and PTEN;These results provide strong experimental evidence showing that the loss of miR-200 family and PTEN expression and increased level of MT1-MMP leads to aggressive behavior of PC cells which could be attenuated through re-expression of miR-200c by CDF and/or BR-DIM treatment suggesting that these agents could be useful for PC treatment |
| 59 | hsa-miR-26a-2-3p | PTEN | 0.03 | 0.91844 | 0.21 | 0.81308 | mirMAP | -0.09 | 0.00411 | ||
| 60 | hsa-miR-30b-5p | PTEN | -0.44 | 0.71874 | 0.21 | 0.81308 | mirMAP | -0.1 | 0.00438 | ||
| 61 | hsa-miR-30e-5p | PTEN | -0.12 | 0.94397 | 0.21 | 0.81308 | mirMAP | -0.11 | 0.01502 | ||
| 62 | hsa-miR-323a-3p | PTEN | 0.01 | 0.98559 | 0.21 | 0.81308 | mirMAP | -0.06 | 0.01371 | ||
| 63 | hsa-miR-452-5p | PTEN | -0.34 | 0.64299 | 0.21 | 0.81308 | mirMAP | -0.08 | 0.00245 | ||
| 64 | hsa-miR-493-5p | PTEN | 0.35 | 0.42488 | 0.21 | 0.81308 | mirMAP | -0.1 | 0.00091 | ||
| 65 | hsa-miR-508-3p | PTEN | -0.98 | 0.02181 | 0.21 | 0.81308 | mirMAP | -0.06 | 0.00347 | ||
| 66 | hsa-miR-590-5p | PTEN | -0.52 | 0.34293 | 0.21 | 0.81308 | mirMAP | -0.14 | 0 | 23803188; 23803188 | miR-590-3p was found to activate PI3K-AKT signaling pathway by down-regulating PTEN to promote AKT1-S473 phosphorylation;MiR-590 is an important tumorigenic factor for HCC and its two arms can both promote tumorigenesis by regulating the expression of their target tumor suppressor gene PDCD4 and PTEN to promote HCC cell proliferation and survival and activate the core tumor signal pathway PI3K-AKT |
| 67 | hsa-miR-7-1-3p | PTEN | -0.86 | 0.23726 | 0.21 | 0.81308 | mirMAP | -0.14 | 0 | ||
| 68 | hsa-miR-106a-5p | PTEN | -0.19 | 0.71237 | 0.21 | 0.81308 | miRNATAP | -0.07 | 0.01491 | ||
| 69 | hsa-miR-3613-5p | PTEN | -0.55 | 0.27041 | 0.21 | 0.81308 | miRNATAP | -0.14 | 0 | ||
| 70 | hsa-miR-200a-3p | PTEN | -1.02 | 0.43063 | 0.21 | 0.81308 | miRNATAP | -0.08 | 1.0E-5 | 24742567; 24742567; 22637745 | 3 In typeIEC loss of PTEN was more frequent in the miR-141 or miR-200a up-regulated subgroups and the correlation between the PTEN and miR-200a status in typeItumors was statistically significant P < 0.05;PTEN might be a potential target of miR-141 and miR-200a in endometrial carcinogenesis;We found loss of expression of miR-200a b and c in chemo-resistant PC cell lines which was correlated with loss of PTEN and over-expression of MT1-MMP |
| 71 | hsa-miR-744-3p | PTEN | -0.73 | 0.14157 | 0.21 | 0.81308 | miRNATAP | -0.11 | 0 | ||
| 72 | hsa-miR-484 | PTEN | -0.18 | 0.83839 | 0.21 | 0.81308 | miRNATAP | -0.13 | 4.0E-5 | ||
| 73 | hsa-miR-212-3p | PTEN | 0.24 | 0.55574 | 0.21 | 0.81308 | miRNATAP | -0.09 | 0.0123 | ||
| 74 | hsa-miR-425-5p | PTEN | -0.63 | 0.56323 | 0.21 | 0.81308 | miRNATAP | -0.11 | 1.0E-5 | 25154996; 25154996; 24571667 | IL-1β induced the up-regulation of miR-425 a negative expression regulator of phosphatase and tensin homolog PTEN;An increase in miR-425 depended upon IL-1β-induced NF-kappaB activation.Repression of PTEN by miR-425 promoted gastric cancer cell proliferation;NF-kappaB-dependent microRNA-425 upregulation promotes gastric cancer cell growth by targeting PTEN upon IL-1β induction |
| Num | GO | Overlap | Size | P Value | Adj. P Value |
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| Num | GO | Overlap | Size | P Value | Adj. P Value |
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| Num | GO | Overlap | Size | P Value | Adj. P Value |
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| Num | Pathway | Pathview | Overlap | Size | P Value | Adj. P Value |
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| Num | lncRNA | miRNAs | miRNAs count | Gene | Sponge regulatory network | lncRNA log2FC | lncRNA pvalue | Gene log2FC | Gene pvalue | lncRNA-gene Pearson correlation |
|---|---|---|---|---|---|---|---|---|---|---|
| 1 | AGAP11 | hsa-let-7a-3p;hsa-let-7b-3p;hsa-let-7f-1-3p;hsa-miR-106a-5p;hsa-miR-106b-5p;hsa-miR-130a-3p;hsa-miR-130b-3p;hsa-miR-136-5p;hsa-miR-141-3p;hsa-miR-142-5p;hsa-miR-148a-3p;hsa-miR-148b-3p;hsa-miR-15b-3p;hsa-miR-16-1-3p;hsa-miR-16-2-3p;hsa-miR-17-5p;hsa-miR-182-5p;hsa-miR-188-5p;hsa-miR-18a-5p;hsa-miR-193a-3p;hsa-miR-193b-3p;hsa-miR-19a-3p;hsa-miR-19b-3p;hsa-miR-200a-3p;hsa-miR-200b-3p;hsa-miR-200c-3p;hsa-miR-20a-5p;hsa-miR-212-3p;hsa-miR-221-3p;hsa-miR-222-3p;hsa-miR-25-3p;hsa-miR-26a-2-3p;hsa-miR-26b-5p;hsa-miR-301a-3p;hsa-miR-30b-5p;hsa-miR-30e-5p;hsa-miR-320a;hsa-miR-320b;hsa-miR-335-3p;hsa-miR-342-3p;hsa-miR-362-3p;hsa-miR-374b-5p;hsa-miR-421;hsa-miR-455-5p;hsa-miR-590-5p;hsa-miR-93-5p | 46 | PTEN | Sponge network | 0.532 | 0.13157 | 0.212 | 0.81308 | 0.332 |
| 2 | LINC00641 | hsa-let-7a-3p;hsa-let-7b-3p;hsa-let-7f-1-3p;hsa-miR-106b-5p;hsa-miR-125a-3p;hsa-miR-130a-3p;hsa-miR-130b-3p;hsa-miR-136-5p;hsa-miR-141-3p;hsa-miR-142-5p;hsa-miR-144-3p;hsa-miR-148a-3p;hsa-miR-148b-3p;hsa-miR-15b-3p;hsa-miR-16-1-3p;hsa-miR-16-2-3p;hsa-miR-17-5p;hsa-miR-182-5p;hsa-miR-186-5p;hsa-miR-188-5p;hsa-miR-18a-5p;hsa-miR-193a-3p;hsa-miR-193b-3p;hsa-miR-19a-3p;hsa-miR-19b-3p;hsa-miR-200a-3p;hsa-miR-200b-3p;hsa-miR-200c-3p;hsa-miR-212-3p;hsa-miR-221-3p;hsa-miR-222-3p;hsa-miR-25-3p;hsa-miR-26a-2-3p;hsa-miR-26b-5p;hsa-miR-29b-3p;hsa-miR-301a-3p;hsa-miR-30d-3p;hsa-miR-320a;hsa-miR-320b;hsa-miR-323a-3p;hsa-miR-337-3p;hsa-miR-342-3p;hsa-miR-3613-5p;hsa-miR-362-3p;hsa-miR-421;hsa-miR-425-5p;hsa-miR-429;hsa-miR-452-5p;hsa-miR-484;hsa-miR-495-3p;hsa-miR-532-5p;hsa-miR-577;hsa-miR-589-3p;hsa-miR-590-3p;hsa-miR-590-5p;hsa-miR-7-1-3p | 56 | PTEN | Sponge network | 0.153 | 0.58604 | 0.212 | 0.81308 | 0.33 |
| 3 | FAM13A-AS1 | hsa-let-7a-3p;hsa-let-7b-3p;hsa-let-7f-1-3p;hsa-miR-106b-5p;hsa-miR-125a-3p;hsa-miR-130b-3p;hsa-miR-141-3p;hsa-miR-142-5p;hsa-miR-148a-3p;hsa-miR-148b-3p;hsa-miR-15b-3p;hsa-miR-16-1-3p;hsa-miR-16-2-3p;hsa-miR-17-5p;hsa-miR-182-5p;hsa-miR-186-5p;hsa-miR-188-5p;hsa-miR-18a-5p;hsa-miR-193b-3p;hsa-miR-19a-3p;hsa-miR-19b-3p;hsa-miR-200a-3p;hsa-miR-200c-3p;hsa-miR-20a-5p;hsa-miR-212-3p;hsa-miR-221-3p;hsa-miR-222-3p;hsa-miR-25-3p;hsa-miR-301a-3p;hsa-miR-32-5p;hsa-miR-323a-3p;hsa-miR-335-3p;hsa-miR-421;hsa-miR-455-5p;hsa-miR-590-3p;hsa-miR-7-1-3p;hsa-miR-744-3p;hsa-miR-92a-3p;hsa-miR-92b-3p;hsa-miR-93-5p | 40 | PTEN | Sponge network | 0.034 | 0.92797 | 0.212 | 0.81308 | 0.325 |
| 4 | RP11-774O3.3 | hsa-let-7a-3p;hsa-let-7b-3p;hsa-let-7f-1-3p;hsa-miR-106a-5p;hsa-miR-106b-5p;hsa-miR-125a-3p;hsa-miR-130a-3p;hsa-miR-130b-3p;hsa-miR-136-5p;hsa-miR-141-3p;hsa-miR-142-5p;hsa-miR-144-3p;hsa-miR-148a-3p;hsa-miR-148b-3p;hsa-miR-15b-3p;hsa-miR-16-1-3p;hsa-miR-16-2-3p;hsa-miR-17-5p;hsa-miR-182-5p;hsa-miR-186-5p;hsa-miR-188-5p;hsa-miR-18a-5p;hsa-miR-193a-3p;hsa-miR-193b-3p;hsa-miR-19a-3p;hsa-miR-19b-3p;hsa-miR-200a-3p;hsa-miR-200b-3p;hsa-miR-200c-3p;hsa-miR-20a-5p;hsa-miR-212-3p;hsa-miR-221-3p;hsa-miR-222-3p;hsa-miR-25-3p;hsa-miR-26a-2-3p;hsa-miR-26b-5p;hsa-miR-29b-3p;hsa-miR-301a-3p;hsa-miR-30b-5p;hsa-miR-30e-5p;hsa-miR-320a;hsa-miR-320b;hsa-miR-323a-3p;hsa-miR-335-3p;hsa-miR-421;hsa-miR-425-5p;hsa-miR-493-5p;hsa-miR-532-5p;hsa-miR-542-3p;hsa-miR-589-3p;hsa-miR-590-3p;hsa-miR-7-1-3p;hsa-miR-744-3p | 53 | PTEN | Sponge network | 0.25 | 0.40256 | 0.212 | 0.81308 | 0.3 |
| 5 | TRAF3IP2-AS1 | hsa-let-7a-3p;hsa-let-7b-3p;hsa-let-7f-1-3p;hsa-miR-106a-5p;hsa-miR-106b-5p;hsa-miR-130b-3p;hsa-miR-136-5p;hsa-miR-141-3p;hsa-miR-142-5p;hsa-miR-144-3p;hsa-miR-148a-3p;hsa-miR-148b-3p;hsa-miR-15b-3p;hsa-miR-16-1-3p;hsa-miR-16-2-3p;hsa-miR-17-5p;hsa-miR-182-5p;hsa-miR-186-5p;hsa-miR-188-5p;hsa-miR-18a-5p;hsa-miR-193b-3p;hsa-miR-19a-3p;hsa-miR-19b-3p;hsa-miR-200a-3p;hsa-miR-200b-3p;hsa-miR-200c-3p;hsa-miR-20a-5p;hsa-miR-212-3p;hsa-miR-221-3p;hsa-miR-222-3p;hsa-miR-25-3p;hsa-miR-26a-2-3p;hsa-miR-26b-5p;hsa-miR-29b-3p;hsa-miR-301a-3p;hsa-miR-32-5p;hsa-miR-320a;hsa-miR-320b;hsa-miR-335-3p;hsa-miR-342-3p;hsa-miR-362-3p;hsa-miR-421;hsa-miR-425-5p;hsa-miR-455-5p;hsa-miR-508-3p;hsa-miR-542-3p;hsa-miR-577;hsa-miR-589-3p;hsa-miR-590-3p;hsa-miR-7-1-3p;hsa-miR-744-3p;hsa-miR-92a-3p;hsa-miR-92b-3p | 53 | PTEN | Sponge network | 0.324 | 0.17879 | 0.212 | 0.81308 | 0.288 |
| 6 | ACTA2-AS1 | hsa-let-7a-3p;hsa-let-7b-3p;hsa-let-7f-1-3p;hsa-miR-106a-5p;hsa-miR-106b-5p;hsa-miR-125a-3p;hsa-miR-130a-3p;hsa-miR-130b-3p;hsa-miR-136-5p;hsa-miR-141-3p;hsa-miR-142-5p;hsa-miR-144-3p;hsa-miR-148a-3p;hsa-miR-148b-3p;hsa-miR-15b-3p;hsa-miR-16-1-3p;hsa-miR-16-2-3p;hsa-miR-17-5p;hsa-miR-182-5p;hsa-miR-186-5p;hsa-miR-188-5p;hsa-miR-18a-5p;hsa-miR-193a-3p;hsa-miR-193b-3p;hsa-miR-19a-3p;hsa-miR-19b-3p;hsa-miR-200a-3p;hsa-miR-200b-3p;hsa-miR-200c-3p;hsa-miR-20a-5p;hsa-miR-212-3p;hsa-miR-221-3p;hsa-miR-222-3p;hsa-miR-25-3p;hsa-miR-26a-2-3p;hsa-miR-26b-5p;hsa-miR-29b-3p;hsa-miR-301a-3p;hsa-miR-3065-3p;hsa-miR-323a-3p;hsa-miR-335-3p;hsa-miR-337-3p;hsa-miR-3613-5p;hsa-miR-374b-5p;hsa-miR-425-5p;hsa-miR-454-3p;hsa-miR-455-5p;hsa-miR-484;hsa-miR-508-3p;hsa-miR-532-5p;hsa-miR-542-3p;hsa-miR-589-3p;hsa-miR-590-3p;hsa-miR-7-1-3p;hsa-miR-744-3p | 55 | PTEN | Sponge network | 1.162 | 0.03353 | 0.212 | 0.81308 | 0.279 |
| 7 | RP11-798M19.6 | hsa-let-7a-3p;hsa-let-7b-3p;hsa-let-7f-1-3p;hsa-miR-106a-5p;hsa-miR-106b-5p;hsa-miR-125a-3p;hsa-miR-130a-3p;hsa-miR-130b-3p;hsa-miR-136-5p;hsa-miR-142-5p;hsa-miR-144-3p;hsa-miR-148a-3p;hsa-miR-148b-3p;hsa-miR-15b-3p;hsa-miR-16-1-3p;hsa-miR-16-2-3p;hsa-miR-17-5p;hsa-miR-182-5p;hsa-miR-186-5p;hsa-miR-188-5p;hsa-miR-18a-5p;hsa-miR-19a-3p;hsa-miR-19b-3p;hsa-miR-200b-3p;hsa-miR-200c-3p;hsa-miR-20a-5p;hsa-miR-212-3p;hsa-miR-221-3p;hsa-miR-222-3p;hsa-miR-25-3p;hsa-miR-26a-2-3p;hsa-miR-26b-5p;hsa-miR-301a-3p;hsa-miR-3065-3p;hsa-miR-323a-3p;hsa-miR-337-3p;hsa-miR-3613-5p;hsa-miR-362-3p;hsa-miR-374a-5p;hsa-miR-374b-5p;hsa-miR-429;hsa-miR-484;hsa-miR-532-5p;hsa-miR-590-3p;hsa-miR-590-5p;hsa-miR-7-1-3p;hsa-miR-744-3p;hsa-miR-93-5p | 48 | PTEN | Sponge network | 0.134 | 0.73364 | 0.212 | 0.81308 | 0.278 |
| 8 | MIR143HG | hsa-let-7a-3p;hsa-let-7b-3p;hsa-let-7f-1-3p;hsa-miR-106a-5p;hsa-miR-106b-5p;hsa-miR-130b-3p;hsa-miR-136-5p;hsa-miR-141-3p;hsa-miR-142-5p;hsa-miR-144-3p;hsa-miR-148a-3p;hsa-miR-148b-3p;hsa-miR-15b-3p;hsa-miR-16-1-3p;hsa-miR-16-2-3p;hsa-miR-17-5p;hsa-miR-182-5p;hsa-miR-186-5p;hsa-miR-188-5p;hsa-miR-18a-5p;hsa-miR-193a-3p;hsa-miR-193b-3p;hsa-miR-19a-3p;hsa-miR-19b-3p;hsa-miR-200a-3p;hsa-miR-200b-3p;hsa-miR-200c-3p;hsa-miR-20a-5p;hsa-miR-212-3p;hsa-miR-221-3p;hsa-miR-222-3p;hsa-miR-25-3p;hsa-miR-26a-2-3p;hsa-miR-26b-5p;hsa-miR-29b-3p;hsa-miR-301a-3p;hsa-miR-3065-3p;hsa-miR-30b-5p;hsa-miR-30d-3p;hsa-miR-30e-5p;hsa-miR-32-5p;hsa-miR-320a;hsa-miR-320b;hsa-miR-323a-3p;hsa-miR-335-3p;hsa-miR-342-3p;hsa-miR-374a-5p;hsa-miR-374b-5p;hsa-miR-425-5p;hsa-miR-429;hsa-miR-452-5p;hsa-miR-455-5p;hsa-miR-484;hsa-miR-493-5p;hsa-miR-532-5p;hsa-miR-542-3p;hsa-miR-577;hsa-miR-589-3p;hsa-miR-590-3p;hsa-miR-590-5p;hsa-miR-7-1-3p;hsa-miR-744-3p;hsa-miR-92a-3p;hsa-miR-92b-3p;hsa-miR-93-5p | 65 | PTEN | Sponge network | 1.436 | 0.00229 | 0.212 | 0.81308 | 0.268 |
| 9 | C20orf166-AS1 | hsa-miR-106a-5p;hsa-miR-106b-5p;hsa-miR-130b-3p;hsa-miR-136-5p;hsa-miR-141-3p;hsa-miR-142-5p;hsa-miR-144-3p;hsa-miR-148a-3p;hsa-miR-148b-3p;hsa-miR-15b-3p;hsa-miR-16-1-3p;hsa-miR-16-2-3p;hsa-miR-17-5p;hsa-miR-182-5p;hsa-miR-188-5p;hsa-miR-18a-5p;hsa-miR-193a-3p;hsa-miR-193b-3p;hsa-miR-19a-3p;hsa-miR-19b-3p;hsa-miR-200a-3p;hsa-miR-200b-3p;hsa-miR-200c-3p;hsa-miR-20a-5p;hsa-miR-212-3p;hsa-miR-221-3p;hsa-miR-222-3p;hsa-miR-25-3p;hsa-miR-26a-2-3p;hsa-miR-26b-5p;hsa-miR-29b-3p;hsa-miR-301a-3p;hsa-miR-320a;hsa-miR-320b;hsa-miR-335-3p;hsa-miR-362-3p;hsa-miR-425-5p;hsa-miR-429;hsa-miR-454-3p;hsa-miR-455-5p;hsa-miR-484;hsa-miR-532-5p;hsa-miR-542-3p;hsa-miR-577;hsa-miR-93-5p | 45 | PTEN | Sponge network | 1.684 | 0.0911 | 0.212 | 0.81308 | 0.265 |
| 10 | RP11-244O19.1 | hsa-let-7a-3p;hsa-let-7b-3p;hsa-let-7f-1-3p;hsa-miR-106a-5p;hsa-miR-106b-5p;hsa-miR-125a-3p;hsa-miR-130b-3p;hsa-miR-136-5p;hsa-miR-141-3p;hsa-miR-142-5p;hsa-miR-144-3p;hsa-miR-148a-3p;hsa-miR-148b-3p;hsa-miR-15b-3p;hsa-miR-16-1-3p;hsa-miR-16-2-3p;hsa-miR-17-5p;hsa-miR-182-5p;hsa-miR-186-5p;hsa-miR-188-5p;hsa-miR-18a-5p;hsa-miR-193a-3p;hsa-miR-193b-3p;hsa-miR-19a-3p;hsa-miR-19b-3p;hsa-miR-200a-3p;hsa-miR-200b-3p;hsa-miR-200c-3p;hsa-miR-20a-5p;hsa-miR-212-3p;hsa-miR-221-3p;hsa-miR-222-3p;hsa-miR-25-3p;hsa-miR-26a-2-3p;hsa-miR-26b-5p;hsa-miR-29b-3p;hsa-miR-301a-3p;hsa-miR-3065-3p;hsa-miR-30b-5p;hsa-miR-30d-3p;hsa-miR-30e-5p;hsa-miR-32-5p;hsa-miR-323a-3p;hsa-miR-337-3p;hsa-miR-342-3p;hsa-miR-362-3p;hsa-miR-484;hsa-miR-532-5p;hsa-miR-577;hsa-miR-589-3p;hsa-miR-590-3p;hsa-miR-92a-3p;hsa-miR-92b-3p;hsa-miR-93-5p | 54 | PTEN | Sponge network | 0.352 | 0.28064 | 0.212 | 0.81308 | 0.262 |
| 11 | RP11-57H14.4 | hsa-let-7a-3p;hsa-let-7b-3p;hsa-let-7f-1-3p;hsa-miR-106a-5p;hsa-miR-106b-5p;hsa-miR-125a-3p;hsa-miR-130a-3p;hsa-miR-130b-3p;hsa-miR-136-5p;hsa-miR-141-3p;hsa-miR-142-5p;hsa-miR-144-3p;hsa-miR-148a-3p;hsa-miR-148b-3p;hsa-miR-15b-3p;hsa-miR-16-1-3p;hsa-miR-16-2-3p;hsa-miR-17-5p;hsa-miR-182-5p;hsa-miR-186-5p;hsa-miR-188-5p;hsa-miR-18a-5p;hsa-miR-193a-3p;hsa-miR-193b-3p;hsa-miR-19a-3p;hsa-miR-19b-3p;hsa-miR-200a-3p;hsa-miR-200b-3p;hsa-miR-200c-3p;hsa-miR-212-3p;hsa-miR-221-3p;hsa-miR-222-3p;hsa-miR-25-3p;hsa-miR-26a-2-3p;hsa-miR-26b-5p;hsa-miR-29b-3p;hsa-miR-301a-3p;hsa-miR-320a;hsa-miR-320b;hsa-miR-362-3p;hsa-miR-425-5p;hsa-miR-455-5p;hsa-miR-484;hsa-miR-493-5p;hsa-miR-495-3p;hsa-miR-532-5p;hsa-miR-542-3p;hsa-miR-577;hsa-miR-590-3p;hsa-miR-7-1-3p | 50 | PTEN | Sponge network | -0.043 | 0.87298 | 0.212 | 0.81308 | 0.261 |
| 12 | HAND2-AS1 | hsa-let-7a-3p;hsa-let-7b-3p;hsa-let-7f-1-3p;hsa-miR-106a-5p;hsa-miR-106b-5p;hsa-miR-125a-3p;hsa-miR-130b-3p;hsa-miR-136-5p;hsa-miR-141-3p;hsa-miR-142-5p;hsa-miR-144-3p;hsa-miR-148a-3p;hsa-miR-148b-3p;hsa-miR-15b-3p;hsa-miR-16-1-3p;hsa-miR-16-2-3p;hsa-miR-17-5p;hsa-miR-182-5p;hsa-miR-186-5p;hsa-miR-188-5p;hsa-miR-18a-5p;hsa-miR-193a-3p;hsa-miR-193b-3p;hsa-miR-19a-3p;hsa-miR-19b-3p;hsa-miR-200a-3p;hsa-miR-200b-3p;hsa-miR-200c-3p;hsa-miR-20a-5p;hsa-miR-212-3p;hsa-miR-221-3p;hsa-miR-222-3p;hsa-miR-25-3p;hsa-miR-26a-2-3p;hsa-miR-26b-5p;hsa-miR-29b-3p;hsa-miR-301a-3p;hsa-miR-3065-3p;hsa-miR-30b-5p;hsa-miR-30d-3p;hsa-miR-30e-5p;hsa-miR-32-5p;hsa-miR-320a;hsa-miR-320b;hsa-miR-335-3p;hsa-miR-3613-5p;hsa-miR-362-3p;hsa-miR-374a-5p;hsa-miR-421;hsa-miR-429;hsa-miR-452-5p;hsa-miR-455-5p;hsa-miR-493-5p;hsa-miR-542-3p;hsa-miR-577;hsa-miR-590-3p;hsa-miR-7-1-3p;hsa-miR-744-3p;hsa-miR-92a-3p;hsa-miR-92b-3p;hsa-miR-93-5p | 61 | PTEN | Sponge network | 3.283 | 6.0E-5 | 0.212 | 0.81308 | 0.26 |
| 13 | LINC00702 | hsa-let-7a-3p;hsa-let-7b-3p;hsa-let-7f-1-3p;hsa-miR-106a-5p;hsa-miR-106b-5p;hsa-miR-130b-3p;hsa-miR-136-5p;hsa-miR-141-3p;hsa-miR-142-5p;hsa-miR-144-3p;hsa-miR-148a-3p;hsa-miR-148b-3p;hsa-miR-15b-3p;hsa-miR-16-1-3p;hsa-miR-16-2-3p;hsa-miR-17-5p;hsa-miR-182-5p;hsa-miR-186-5p;hsa-miR-188-5p;hsa-miR-18a-5p;hsa-miR-193a-3p;hsa-miR-193b-3p;hsa-miR-19a-3p;hsa-miR-19b-3p;hsa-miR-200a-3p;hsa-miR-200b-3p;hsa-miR-200c-3p;hsa-miR-20a-5p;hsa-miR-212-3p;hsa-miR-221-3p;hsa-miR-222-3p;hsa-miR-25-3p;hsa-miR-26a-2-3p;hsa-miR-26b-5p;hsa-miR-29b-3p;hsa-miR-301a-3p;hsa-miR-3065-3p;hsa-miR-30b-5p;hsa-miR-30d-3p;hsa-miR-30e-5p;hsa-miR-32-5p;hsa-miR-320a;hsa-miR-320b;hsa-miR-323a-3p;hsa-miR-335-3p;hsa-miR-342-3p;hsa-miR-3613-5p;hsa-miR-362-3p;hsa-miR-374b-5p;hsa-miR-421;hsa-miR-425-5p;hsa-miR-454-3p;hsa-miR-455-5p;hsa-miR-484;hsa-miR-508-3p;hsa-miR-532-5p;hsa-miR-542-3p;hsa-miR-577;hsa-miR-589-3p;hsa-miR-590-3p;hsa-miR-590-5p;hsa-miR-7-1-3p;hsa-miR-744-3p;hsa-miR-92a-3p;hsa-miR-92b-3p;hsa-miR-93-5p | 66 | PTEN | Sponge network | 1.675 | 0.00365 | 0.212 | 0.81308 | 0.259 |
| 14 | PWAR6 | hsa-let-7a-3p;hsa-let-7b-3p;hsa-let-7f-1-3p;hsa-miR-106a-5p;hsa-miR-106b-5p;hsa-miR-125a-3p;hsa-miR-130b-3p;hsa-miR-136-5p;hsa-miR-141-3p;hsa-miR-142-5p;hsa-miR-144-3p;hsa-miR-148a-3p;hsa-miR-148b-3p;hsa-miR-15b-3p;hsa-miR-16-1-3p;hsa-miR-16-2-3p;hsa-miR-17-5p;hsa-miR-182-5p;hsa-miR-186-5p;hsa-miR-188-5p;hsa-miR-18a-5p;hsa-miR-193a-3p;hsa-miR-193b-3p;hsa-miR-19a-3p;hsa-miR-19b-3p;hsa-miR-200a-3p;hsa-miR-200b-3p;hsa-miR-200c-3p;hsa-miR-20a-5p;hsa-miR-212-3p;hsa-miR-221-3p;hsa-miR-222-3p;hsa-miR-25-3p;hsa-miR-26a-2-3p;hsa-miR-26b-5p;hsa-miR-29b-3p;hsa-miR-301a-3p;hsa-miR-30b-5p;hsa-miR-30d-3p;hsa-miR-30e-5p;hsa-miR-320a;hsa-miR-320b;hsa-miR-323a-3p;hsa-miR-335-3p;hsa-miR-342-3p;hsa-miR-362-3p;hsa-miR-374b-5p;hsa-miR-421;hsa-miR-429;hsa-miR-452-5p;hsa-miR-454-3p;hsa-miR-455-5p;hsa-miR-493-5p;hsa-miR-577;hsa-miR-589-3p;hsa-miR-590-3p;hsa-miR-590-5p;hsa-miR-7-1-3p;hsa-miR-93-5p | 59 | PTEN | Sponge network | 1.781 | 0.00504 | 0.212 | 0.81308 | 0.258 |
| 15 | MYLK-AS1 | hsa-miR-106a-5p;hsa-miR-106b-5p;hsa-miR-125a-3p;hsa-miR-130b-3p;hsa-miR-136-5p;hsa-miR-141-3p;hsa-miR-142-5p;hsa-miR-148a-3p;hsa-miR-148b-3p;hsa-miR-15b-3p;hsa-miR-17-5p;hsa-miR-182-5p;hsa-miR-186-5p;hsa-miR-18a-5p;hsa-miR-193a-3p;hsa-miR-193b-3p;hsa-miR-19a-3p;hsa-miR-19b-3p;hsa-miR-200a-3p;hsa-miR-200b-3p;hsa-miR-200c-3p;hsa-miR-20a-5p;hsa-miR-221-3p;hsa-miR-222-3p;hsa-miR-25-3p;hsa-miR-26a-2-3p;hsa-miR-26b-5p;hsa-miR-29b-3p;hsa-miR-301a-3p;hsa-miR-3065-3p;hsa-miR-484 | 31 | PTEN | Sponge network | 1.281 | 0.00315 | 0.212 | 0.81308 | 0.257 |
| 16 | CTC-429P9.1 | hsa-miR-106a-5p;hsa-miR-106b-5p;hsa-miR-125a-3p;hsa-miR-142-5p;hsa-miR-144-3p;hsa-miR-148a-3p;hsa-miR-148b-3p;hsa-miR-15b-3p;hsa-miR-16-1-3p;hsa-miR-17-5p;hsa-miR-182-5p;hsa-miR-186-5p;hsa-miR-188-5p;hsa-miR-18a-5p;hsa-miR-19a-3p;hsa-miR-200b-3p;hsa-miR-200c-3p;hsa-miR-221-3p;hsa-miR-25-3p;hsa-miR-26a-2-3p;hsa-miR-301a-3p;hsa-miR-323a-3p;hsa-miR-335-3p;hsa-miR-3613-5p;hsa-miR-93-5p | 25 | PTEN | Sponge network | 0.441 | 0.05571 | 0.212 | 0.81308 | 0.255 |
| 17 | CTC-429P9.5 | hsa-let-7a-3p;hsa-let-7b-3p;hsa-let-7f-1-3p;hsa-miR-106a-5p;hsa-miR-106b-5p;hsa-miR-125a-3p;hsa-miR-130a-3p;hsa-miR-130b-3p;hsa-miR-136-5p;hsa-miR-144-3p;hsa-miR-148a-3p;hsa-miR-148b-3p;hsa-miR-16-1-3p;hsa-miR-16-2-3p;hsa-miR-17-5p;hsa-miR-182-5p;hsa-miR-186-5p;hsa-miR-18a-5p;hsa-miR-19a-3p;hsa-miR-19b-3p;hsa-miR-20a-5p;hsa-miR-25-3p;hsa-miR-26b-5p;hsa-miR-301a-3p;hsa-miR-374b-5p;hsa-miR-421;hsa-miR-425-5p;hsa-miR-454-3p;hsa-miR-532-5p;hsa-miR-590-3p;hsa-miR-744-3p | 31 | PTEN | Sponge network | 0.2 | 0.27483 | 0.212 | 0.81308 | 0.254 |
| 18 | CTC-429P9.2 | hsa-miR-106a-5p;hsa-miR-106b-5p;hsa-miR-125a-3p;hsa-miR-130a-3p;hsa-miR-136-5p;hsa-miR-17-5p;hsa-miR-182-5p;hsa-miR-186-5p;hsa-miR-18a-5p;hsa-miR-20a-5p;hsa-miR-221-3p;hsa-miR-222-3p;hsa-miR-301a-3p;hsa-miR-532-5p;hsa-miR-542-3p | 15 | PTEN | Sponge network | 0.233 | 0.25783 | 0.212 | 0.81308 | 0.253 |
| 19 | DNM3OS | hsa-let-7a-3p;hsa-let-7b-3p;hsa-let-7f-1-3p;hsa-miR-106a-5p;hsa-miR-106b-5p;hsa-miR-130b-3p;hsa-miR-136-5p;hsa-miR-141-3p;hsa-miR-142-5p;hsa-miR-144-3p;hsa-miR-148a-3p;hsa-miR-148b-3p;hsa-miR-15b-3p;hsa-miR-16-1-3p;hsa-miR-16-2-3p;hsa-miR-17-5p;hsa-miR-182-5p;hsa-miR-186-5p;hsa-miR-188-5p;hsa-miR-18a-5p;hsa-miR-193a-3p;hsa-miR-193b-3p;hsa-miR-19a-3p;hsa-miR-19b-3p;hsa-miR-200a-3p;hsa-miR-200b-3p;hsa-miR-200c-3p;hsa-miR-20a-5p;hsa-miR-212-3p;hsa-miR-25-3p;hsa-miR-26a-2-3p;hsa-miR-26b-5p;hsa-miR-29b-3p;hsa-miR-301a-3p;hsa-miR-3065-3p;hsa-miR-30d-3p;hsa-miR-320a;hsa-miR-320b;hsa-miR-323a-3p;hsa-miR-374a-5p;hsa-miR-374b-5p;hsa-miR-429;hsa-miR-454-3p;hsa-miR-455-5p;hsa-miR-484;hsa-miR-508-3p;hsa-miR-577;hsa-miR-590-3p;hsa-miR-590-5p;hsa-miR-7-1-3p;hsa-miR-744-3p;hsa-miR-93-5p | 52 | PTEN | Sponge network | 0.938 | 0.00139 | 0.212 | 0.81308 | 0.251 |
| 20 | RP11-720L2.4 | hsa-let-7a-3p;hsa-let-7b-3p;hsa-let-7f-1-3p;hsa-miR-106a-5p;hsa-miR-106b-5p;hsa-miR-130b-3p;hsa-miR-16-1-3p;hsa-miR-16-2-3p;hsa-miR-17-5p;hsa-miR-182-5p;hsa-miR-186-5p;hsa-miR-188-5p;hsa-miR-18a-5p;hsa-miR-193a-3p;hsa-miR-193b-3p;hsa-miR-19a-3p;hsa-miR-19b-3p;hsa-miR-20a-5p;hsa-miR-25-3p;hsa-miR-26a-2-3p;hsa-miR-362-3p;hsa-miR-93-5p | 22 | PTEN | Sponge network | 2.18 | 0.0005 | 0.212 | 0.81308 | 0.251 |
| 21 | MALAT1 | hsa-let-7a-3p;hsa-let-7b-3p;hsa-let-7f-1-3p;hsa-miR-106b-5p;hsa-miR-125a-3p;hsa-miR-130a-3p;hsa-miR-130b-3p;hsa-miR-136-5p;hsa-miR-142-5p;hsa-miR-144-3p;hsa-miR-148a-3p;hsa-miR-148b-3p;hsa-miR-15b-3p;hsa-miR-16-2-3p;hsa-miR-182-5p;hsa-miR-186-5p;hsa-miR-188-5p;hsa-miR-193b-3p;hsa-miR-212-3p;hsa-miR-222-3p;hsa-miR-26a-2-3p;hsa-miR-26b-5p;hsa-miR-29b-3p;hsa-miR-30b-5p;hsa-miR-30e-5p;hsa-miR-32-5p;hsa-miR-320a;hsa-miR-320b;hsa-miR-323a-3p;hsa-miR-337-3p;hsa-miR-374b-5p;hsa-miR-429;hsa-miR-484;hsa-miR-493-5p;hsa-miR-495-3p;hsa-miR-590-3p;hsa-miR-590-5p;hsa-miR-7-1-3p;hsa-miR-744-3p | 39 | PTEN | Sponge network | 0.28 | 0.74973 | 0.212 | 0.81308 | 0.25 |