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This regulatory network was inferred from the input dataset. The miRNAs and mRNAs are presented as round and rectangle nodes respectively. The numerical value popped up upon mouse over the gene node is the log2 transformed fold-change of the gene expression between the two groups. All of the nodes are clickable, and the detailed information of the miRNAs/mRNAs and related cancer pathway will be displayed in another window. The edges between nodes are supported by both interactions (predicted or experimentally verified) and correlations learnt from cancer dataset. The numerical value popped up upon mouse over the edge is the correlation beat value (effect size) between the two nodes. The experimental evidences of the edges reported in previous cancer studies are highlighted by red/orange color. All of these information can be accessed by the "mouse-over" action. This network shows a full map of the miRNA-mRNA regulation of the input gene list(s), and the hub miRNAs (with the high network degree/betweenness centrality) would be the potential cancer drivers or tumor suppressors. The full result table can be accessed in the "Regulations" tab.

"miRNACancerMAP" is also a network visualization tool for users to draw their regulatory network by personal customization. Users can set the complexity of the network by limiting the number of nodes or edges. And the color of the nodes can be defined by different categories of the mRNAs and miRNAs, such as Gene-Ontology, pathway, and expression status. Users can also select to use network degree or network betweenness centrality to define the node size. And edges can be black or colored by the correlation. Purple edge means negative correlation (mostly found between miRNA and mRNA), and blue edge means positive correlation (found in PPI or miRNA-miRNA sponge effect). We can also add the protein-protein interactions (PPI) into the network. This result will show the cluster of genes regulated by some specific miRNAs. Additionally, miRNA-miRNA edges can be added by the "miRNA sponge" button, presenting some clusters of miRNAs that have the interactions via sponge effect.

miRNA-gene regulations

(Download full result)

Num microRNA           Gene miRNA log2FC miRNA pvalue Gene log2FC Gene pvalue Interaction Correlation beta Correlation P-value PMID Reported in cancer studies
1 hsa-miR-495-3p ADAM17 0 0.99753 0.23 0.8262 mirMAP -0.14 0.0001 NA
2 hsa-miR-493-5p CREBBP 0.23 0.73198 -0.07 0.96314 miRNATAP -0.13 0.00036 NA
3 hsa-miR-362-5p DLL1 -0.27 0.75202 -0.01 0.98681 PITA; TargetScan; miRNATAP -0.23 0.00015 NA
4 hsa-miR-15b-5p DLL4 -0.27 0.87097 -0.14 0.89656 miRNATAP -0.14 0.00904 NA
5 hsa-miR-188-5p DTX1 -0.57 0.32482 0.14 0.75752 PITA -0.25 4.0E-5 NA
6 hsa-miR-194-3p DTX1 -0.61 0.73321 0.14 0.75752 miRNATAP -0.35 0 NA
7 hsa-miR-335-5p DTX1 -0.03 0.97338 0.14 0.75752 miRNAWalker2 validate -0.22 0.00347 NA
8 hsa-miR-421 DTX1 -0.18 0.7347 0.14 0.75752 PITA; miRanda; miRNATAP -0.41 0 NA
9 hsa-miR-484 DTX1 -0.18 0.88633 0.14 0.75752 miRNATAP -0.33 0.00169 NA
10 hsa-let-7e-5p DTX2 0.21 0.92234 -0.13 0.92812 miRNATAP -0.15 0.00759 NA
11 hsa-miR-107 DTX3 -0.04 0.98836 0.53 0.448 miRanda -0.81 0 NA
12 hsa-miR-148a-5p DTX3 -0.45 0.74842 0.53 0.448 mirMAP -0.53 0 NA
13 hsa-miR-185-5p DTX3 -0.29 0.82059 0.53 0.448 MirTarget -0.6 0 NA
14 hsa-let-7i-5p DTX4 -0.2 0.92202 0.05 0.97434 miRNATAP -0.17 0.00881 NA
15 hsa-miR-221-3p DVL2 0.09 0.95912 -0.17 0.88279 miRNAWalker2 validate -0.11 0.0034 21487968 MiR 221 expression affects invasion potential of human prostate carcinoma cell lines by targeting DVL2; We also suggest that miR-221 may control the migration of AIPC cells through DVL2 working as a key regulator in advanced CaP
16 hsa-miR-21-5p DVL3 -0.15 0.97024 0.02 0.98794 mirMAP -0.13 0.00029 NA
17 hsa-miR-106b-5p EP300 -0.3 0.86929 -0.28 0.85828 miRNATAP -0.13 0.00096 NA
18 hsa-miR-26b-5p EP300 -0.02 0.99038 -0.28 0.85828 miRNAWalker2 validate; miRNATAP -0.12 0.00816 NA
19 hsa-miR-339-5p EP300 -0.3 0.71291 -0.28 0.85828 miRanda -0.11 0.00013 NA
20 hsa-miR-369-3p EP300 0.12 0.8323 -0.28 0.85828 MirTarget; PITA; miRNATAP -0.15 1.0E-5 NA
21 hsa-miR-30a-5p HDAC1 0.22 0.93395 -0.2 0.91427 miRNAWalker2 validate -0.22 1.0E-5 NA
22 hsa-miR-34c-5p HDAC1 -0.02 0.95279 -0.2 0.91427 miRanda; miRNATAP -0.14 1.0E-5 NA
23 hsa-miR-132-3p HDAC2 -0.24 0.87175 -0.09 0.95418 mirMAP -0.17 0.00036 NA
24 hsa-miR-155-5p HDAC2 -0.41 0.82867 -0.09 0.95418 mirMAP -0.11 0.00036 21946536 Mechanistically we found that BRCA1 epigenetically represses miR-155 expression via its association with HDAC2 which deacetylates histones H2A and H3 on the miR-155 promoter
25 hsa-miR-92b-3p HDAC2 -0.57 0.68932 -0.09 0.95418 mirMAP -0.11 0.00023 NA
26 hsa-miR-335-3p JAG1 -0.24 0.8845 -0.02 0.98774 MirTarget -0.15 0.00241 NA
27 hsa-miR-335-5p JAG1 -0.03 0.97338 -0.02 0.98774 miRNATAP -0.19 8.0E-5 NA
28 hsa-miR-548o-3p JAG1 -0.19 0.51773 -0.02 0.98774 MirTarget -0.13 0.00858 NA
29 hsa-miR-93-3p JAG1 -0.44 0.5499 -0.02 0.98774 MirTarget; miRNATAP -0.13 0.00907 NA
30 hsa-miR-106a-5p KAT2B -0.2 0.80221 -0.04 0.9657 MirTarget -0.26 1.0E-5 NA
31 hsa-miR-106b-5p KAT2B -0.3 0.86929 -0.04 0.9657 miRNAWalker2 validate; miRTarBase; MirTarget -0.32 0 NA
32 hsa-miR-1304-5p KAT2B -0.5 0.16308 -0.04 0.9657 MirTarget -0.17 0.00012 NA
33 hsa-miR-17-5p KAT2B -0.18 0.93454 -0.04 0.9657 MirTarget; TargetScan -0.3 0 23095762 miR 17 5p targets the p300/CBP associated factor and modulates androgen receptor transcriptional activity in cultured prostate cancer cells; Targeting of PCAF by miR-17-5p was evaluated using the luciferase reporter assay; Expression of PCAF in PCa cells was associated with the downregulation of miR-17-5p; Targeting of the 3'-untranslated region of PCAF mRNA by miR-17-5p caused translational suppression and RNA degradation and consequently modulation of AR transcriptional activity in PCa cells; PCAF is upregulated in cultured PCa cells and upregulation of PCAF is associated with the downregulation of miR-17-5p; Targeting of PCAF by miR-17-5p modulates AR transcriptional activity and cell growth in cultured PCa cells
34 hsa-miR-192-5p KAT2B -0.12 0.97293 -0.04 0.9657 miRNAWalker2 validate -0.15 0.00152 NA
35 hsa-miR-19a-3p KAT2B -0.21 0.84464 -0.04 0.9657 miRNAWalker2 validate -0.27 0 NA
36 hsa-miR-19b-3p KAT2B -0.03 0.98666 -0.04 0.9657 miRNAWalker2 validate -0.33 0 NA
37 hsa-miR-20a-3p KAT2B 0.46 0.57674 -0.04 0.9657 MirTarget -0.23 0 NA
38 hsa-miR-20a-5p KAT2B -0.18 0.92812 -0.04 0.9657 MirTarget -0.26 0 NA
39 hsa-miR-25-3p KAT2B -0.46 0.87857 -0.04 0.9657 miRNAWalker2 validate; miRTarBase; MirTarget -0.26 0.00199 NA
40 hsa-miR-29a-5p KAT2B -0.32 0.60044 -0.04 0.9657 MirTarget -0.27 0 NA
41 hsa-miR-32-5p KAT2B -0.06 0.95298 -0.04 0.9657 miRNAWalker2 validate; miRTarBase; MirTarget -0.2 0.00064 NA
42 hsa-miR-590-3p KAT2B -0.28 0.59127 -0.04 0.9657 MirTarget; miRanda; mirMAP; miRNATAP -0.13 0.00828 NA
43 hsa-miR-590-5p KAT2B -0.55 0.47274 -0.04 0.9657 miRanda -0.22 3.0E-5 NA
44 hsa-miR-92a-3p KAT2B 0.03 0.99325 -0.04 0.9657 miRNAWalker2 validate; MirTarget -0.34 0 NA
45 hsa-miR-93-5p KAT2B -0.61 0.8253 -0.04 0.9657 miRNAWalker2 validate; miRTarBase; MirTarget -0.23 0.0003 NA
46 hsa-miR-132-3p LFNG -0.24 0.87175 0.31 0.8447 miRNAWalker2 validate -0.3 0.0003 NA
47 hsa-miR-146b-5p LFNG -0.4 0.83751 0.31 0.8447 PITA; miRanda; miRNATAP -0.2 0.00095 NA
48 hsa-miR-126-5p MAML2 0.08 0.95664 0.12 0.8967 mirMAP -0.25 0.00075 NA
49 hsa-miR-324-5p MAML2 -0.5 0.53742 0.12 0.8967 miRanda -0.25 2.0E-5 NA
50 hsa-miR-429 MAML2 -0.46 0.80624 0.12 0.8967 miRanda -0.15 0.00072 NA
51 hsa-miR-576-5p MAML2 -0.51 0.41719 0.12 0.8967 mirMAP -0.27 0 NA
52 hsa-miR-590-3p MAML2 -0.28 0.59127 0.12 0.8967 mirMAP -0.24 0 NA
53 hsa-miR-335-5p MFNG -0.03 0.97338 0.01 0.98495 miRNAWalker2 validate -0.34 0 NA
54 hsa-miR-590-3p MFNG -0.28 0.59127 0.01 0.98495 miRanda -0.21 3.0E-5 NA
55 hsa-miR-939-5p MFNG -0.31 0.30445 0.01 0.98495 MirTarget -0.3 0 NA
56 hsa-miR-106a-5p NOTCH2 -0.2 0.80221 -0.29 0.84538 miRNAWalker2 validate -0.2 1.0E-5 NA
57 hsa-miR-130b-5p NOTCH2 -0.65 0.3791 -0.29 0.84538 miRNAWalker2 validate; MirTarget -0.16 0.00029 NA
58 hsa-miR-148a-5p NOTCH2 -0.45 0.74842 -0.29 0.84538 MirTarget -0.16 0.00048 NA
59 hsa-miR-15a-5p NOTCH2 -0.07 0.96484 -0.29 0.84538 MirTarget -0.22 4.0E-5 NA
60 hsa-miR-15b-5p NOTCH2 -0.27 0.87097 -0.29 0.84538 MirTarget -0.18 0.00039 NA
61 hsa-miR-16-1-3p NOTCH2 0.15 0.73374 -0.29 0.84538 mirMAP -0.11 0.00905 NA
62 hsa-miR-16-5p NOTCH2 0.01 0.99448 -0.29 0.84538 miRNAWalker2 validate; MirTarget -0.28 0 NA
63 hsa-miR-17-5p NOTCH2 -0.18 0.93454 -0.29 0.84538 miRNAWalker2 validate -0.24 0 NA
64 hsa-miR-183-5p NOTCH2 -0.05 0.98486 -0.29 0.84538 miRNAWalker2 validate -0.16 2.0E-5 NA
65 hsa-miR-186-5p NOTCH2 -0.32 0.85413 -0.29 0.84538 mirMAP -0.17 0.00694 NA
66 hsa-miR-18a-3p NOTCH2 -0.27 0.53529 -0.29 0.84538 MirTarget -0.12 0.00047 NA
67 hsa-miR-196a-5p NOTCH2 -0.06 0.97309 -0.29 0.84538 miRNAWalker2 validate -0.13 0 NA
68 hsa-miR-200a-5p NOTCH2 -0.67 0.78126 -0.29 0.84538 mirMAP -0.13 0.00163 NA
69 hsa-miR-200b-5p NOTCH2 -0.5 0.72226 -0.29 0.84538 mirMAP -0.18 1.0E-5 NA
70 hsa-miR-25-3p NOTCH2 -0.46 0.87857 -0.29 0.84538 miRNAWalker2 validate -0.27 3.0E-5 NA
71 hsa-miR-29a-3p NOTCH2 0.01 0.99698 -0.29 0.84538 MirTarget -0.33 0 NA
72 hsa-miR-29b-3p NOTCH2 -0.1 0.95899 -0.29 0.84538 MirTarget -0.21 0 NA
73 hsa-miR-30b-5p NOTCH2 -0.01 0.99462 -0.29 0.84538 mirMAP -0.3 0 NA
74 hsa-miR-30c-5p NOTCH2 -0.3 0.86581 -0.29 0.84538 mirMAP -0.27 3.0E-5 NA
75 hsa-miR-374a-5p NOTCH2 -0.34 0.76692 -0.29 0.84538 mirMAP -0.27 3.0E-5 NA
76 hsa-miR-374b-5p NOTCH2 -0.29 0.8357 -0.29 0.84538 mirMAP -0.3 0 NA
77 hsa-miR-421 NOTCH2 -0.18 0.7347 -0.29 0.84538 miRanda -0.2 0 NA
78 hsa-miR-423-5p NOTCH2 -0.14 0.91245 -0.29 0.84538 MirTarget -0.16 0.0038 NA
79 hsa-miR-424-5p NOTCH2 0.25 0.87015 -0.29 0.84538 MirTarget -0.16 3.0E-5 NA
80 hsa-miR-429 NOTCH2 -0.46 0.80624 -0.29 0.84538 miRNATAP -0.16 0 NA
81 hsa-miR-491-3p NOTCH2 -0.51 0.13784 -0.29 0.84538 PITA -0.11 0.00383 NA
82 hsa-miR-590-3p NOTCH2 -0.28 0.59127 -0.29 0.84538 miRanda -0.21 0 NA
83 hsa-miR-590-5p NOTCH2 -0.55 0.47274 -0.29 0.84538 miRanda -0.24 0 NA
84 hsa-miR-92a-3p NOTCH2 0.03 0.99325 -0.29 0.84538 miRNAWalker2 validate -0.28 0 NA
85 hsa-miR-940 NOTCH2 -0.23 0.68006 -0.29 0.84538 MirTarget -0.16 0 NA
86 hsa-miR-942-5p NOTCH2 -0.51 0.50778 -0.29 0.84538 MirTarget -0.11 0.00406 NA
87 hsa-miR-200a-3p NOTCH3 -0.37 0.85106 0.27 0.85209 mirMAP -0.36 0 NA
88 hsa-miR-335-5p NOTCH3 -0.03 0.97338 0.27 0.85209 miRNAWalker2 validate -0.46 0 NA
89 hsa-miR-484 NOTCH3 -0.18 0.88633 0.27 0.85209 miRNAWalker2 validate -0.42 0 NA
90 hsa-miR-660-5p NOTCH3 -0.48 0.69408 0.27 0.85209 MirTarget -0.42 0 NA
91 hsa-miR-7-5p NOTCH3 0.21 0.77371 0.27 0.85209 MirTarget -0.18 8.0E-5 NA
92 hsa-miR-18a-3p NOTCH4 -0.27 0.53529 0.41 0.63905 miRNAWalker2 validate -0.17 1.0E-5 NA
93 hsa-miR-324-5p NOTCH4 -0.5 0.53742 0.41 0.63905 miRanda -0.23 3.0E-5 NA
94 hsa-miR-421 NOTCH4 -0.18 0.7347 0.41 0.63905 miRanda -0.2 8.0E-5 NA
95 hsa-miR-429 NOTCH4 -0.46 0.80624 0.41 0.63905 miRNATAP -0.27 0 NA
96 hsa-let-7g-5p NUMBL -0.2 0.92299 0.14 0.87569 miRNATAP -0.33 1.0E-5 NA
97 hsa-miR-141-3p NUMBL -0.32 0.87774 0.14 0.87569 TargetScan -0.26 0 NA
98 hsa-miR-194-3p NUMBL -0.61 0.73321 0.14 0.87569 MirTarget -0.34 0 NA
99 hsa-miR-362-3p NUMBL -0.72 0.03459 0.14 0.87569 miRanda; miRNATAP -0.16 4.0E-5 NA
100 hsa-miR-374b-5p NUMBL -0.29 0.8357 0.14 0.87569 miRNATAP -0.29 0 NA
101 hsa-miR-421 NUMBL -0.18 0.7347 0.14 0.87569 miRanda; miRNATAP -0.24 0 NA
102 hsa-miR-361-5p PSEN1 -0.14 0.9415 0.03 0.98519 miRanda -0.15 0.00109 NA
103 hsa-miR-326 PSEN2 -0.57 0.6207 0.27 0.78826 miRanda -0.11 0.00505 NA
104 hsa-miR-369-3p RBPJ 0.12 0.8323 -0.17 0.87141 MirTarget -0.1 0.00013 NA
105 hsa-miR-374b-5p RBPJ -0.29 0.8357 -0.17 0.87141 mirMAP -0.11 0.00381 NA

Over-represented Gene Ontology Biological Process

NumGOOverlapSizeP ValueAdj. P Value
1 NOTCH SIGNALING PATHWAY 18 114 4.59e-36 2.136e-32
2 NOTCH RECEPTOR PROCESSING 8 16 2.182e-20 5.077e-17
3 ANATOMICAL STRUCTURE FORMATION INVOLVED IN MORPHOGENESIS 14 957 8.184e-13 1.269e-09
4 B CELL DIFFERENTIATION 7 89 1.224e-11 1.424e-08
5 EPITHELIUM DEVELOPMENT 13 945 1.654e-11 1.539e-08
6 REGULATION OF NERVOUS SYSTEM DEVELOPMENT 12 750 2.354e-11 1.826e-08
7 IMMUNE SYSTEM DEVELOPMENT 11 582 3.553e-11 2.362e-08
8 LEUKOCYTE DIFFERENTIATION 9 292 4.437e-11 2.581e-08
9 REGULATION OF MULTICELLULAR ORGANISMAL DEVELOPMENT 15 1672 9.364e-11 4.357e-08
10 ORGAN MORPHOGENESIS 12 841 8.877e-11 4.357e-08
11 LYMPHOCYTE DIFFERENTIATION 8 209 1.155e-10 4.884e-08
12 HEART MORPHOGENESIS 8 212 1.294e-10 5.016e-08
13 POSITIVE REGULATION OF GENE EXPRESSION 15 1733 1.557e-10 5.506e-08
14 EMBRYO DEVELOPMENT 12 894 1.797e-10 5.506e-08
15 LYMPHOCYTE ACTIVATION 9 342 1.807e-10 5.506e-08
16 REGULATION OF NOTCH SIGNALING PATHWAY 6 67 1.893e-10 5.506e-08
17 B CELL ACTIVATION 7 132 2.023e-10 5.537e-08
18 CELL FATE COMMITMENT 8 227 2.23e-10 5.764e-08
19 TISSUE DEVELOPMENT 14 1518 3.99e-10 9.771e-08
20 POSITIVE REGULATION OF NOTCH SIGNALING PATHWAY 5 34 5.414e-10 1.26e-07
21 TRANSCRIPTION INITIATION FROM RNA POLYMERASE II PROMOTER 7 153 5.72e-10 1.267e-07
22 MORPHOGENESIS OF AN EPITHELIUM 9 400 7.206e-10 1.524e-07
23 CARDIOVASCULAR SYSTEM DEVELOPMENT 11 788 8.913e-10 1.728e-07
24 CIRCULATORY SYSTEM DEVELOPMENT 11 788 8.913e-10 1.728e-07
25 LEUKOCYTE ACTIVATION 9 414 9.75e-10 1.799e-07
26 SEGMENTATION 6 89 1.083e-09 1.799e-07
27 NEGATIVE REGULATION OF DEVELOPMENTAL PROCESS 11 801 1.059e-09 1.799e-07
28 PATTERN SPECIFICATION PROCESS 9 418 1.061e-09 1.799e-07
29 MATURE B CELL DIFFERENTIATION INVOLVED IN IMMUNE RESPONSE 4 13 1.347e-09 2.161e-07
30 HEART DEVELOPMENT 9 466 2.749e-09 4.264e-07
31 CELL SURFACE RECEPTOR SIGNALING PATHWAY INVOLVED IN HEART DEVELOPMENT 4 16 3.42e-09 5.133e-07
32 POSITIVE REGULATION OF BIOSYNTHETIC PROCESS 14 1805 3.881e-09 5.613e-07
33 DNA TEMPLATED TRANSCRIPTION INITIATION 7 202 3.981e-09 5.613e-07
34 MATURE B CELL DIFFERENTIATION 4 17 4.468e-09 6.115e-07
35 REGULATION OF CELL DIFFERENTIATION 13 1492 4.68e-09 6.222e-07
36 POSITIVE REGULATION OF CELL COMMUNICATION 13 1532 6.455e-09 8.343e-07
37 TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 10 724 7.255e-09 9.124e-07
38 TISSUE MORPHOGENESIS 9 533 8.855e-09 1.084e-06
39 POSITIVE REGULATION OF RESPONSE TO STIMULUS 14 1929 9.208e-09 1.099e-06
40 POSITIVE REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 11 1004 1.125e-08 1.309e-06
41 REGULATION OF NEURON DIFFERENTIATION 9 554 1.238e-08 1.339e-06
42 SOMITOGENESIS 5 62 1.23e-08 1.339e-06
43 TUBE DEVELOPMENT 9 552 1.2e-08 1.339e-06
44 CELL ACTIVATION 9 568 1.536e-08 1.624e-06
45 REGULATION OF CELL DEVELOPMENT 10 836 2.849e-08 2.882e-06
46 NEGATIVE REGULATION OF CELL DIFFERENTIATION 9 609 2.803e-08 2.882e-06
47 SOMITE DEVELOPMENT 5 78 3.96e-08 3.92e-06
48 REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 13 1784 4.046e-08 3.922e-06
49 REGIONALIZATION 7 311 7.769e-08 7.377e-06
50 ENDOTHELIUM DEVELOPMENT 5 90 8.161e-08 7.594e-06
51 SENSORY ORGAN DEVELOPMENT 8 493 9.633e-08 8.664e-06
52 B CELL ACTIVATION INVOLVED IN IMMUNE RESPONSE 4 35 9.683e-08 8.664e-06
53 TUBE MORPHOGENESIS 7 323 1.006e-07 8.828e-06
54 NEGATIVE REGULATION OF NEURON DIFFERENTIATION 6 191 1.068e-07 9.201e-06
55 LYMPHOCYTE ACTIVATION INVOLVED IN IMMUNE RESPONSE 5 98 1.253e-07 1.06e-05
56 CARDIAC CHAMBER MORPHOGENESIS 5 104 1.688e-07 1.402e-05
57 EMBRYONIC MORPHOGENESIS 8 539 1.907e-07 1.517e-05
58 REGULATION OF ANATOMICAL STRUCTURE MORPHOGENESIS 10 1021 1.863e-07 1.517e-05
59 SKIN DEVELOPMENT 6 211 1.924e-07 1.517e-05
60 MORPHOGENESIS OF AN EPITHELIAL SHEET 4 43 2.267e-07 1.729e-05
61 CELL FATE DETERMINATION 4 43 2.267e-07 1.729e-05
62 NEUROGENESIS 11 1402 3.44e-07 2.582e-05
63 SENSORY ORGAN MORPHOGENESIS 6 239 4.005e-07 2.958e-05
64 ARTERY MORPHOGENESIS 4 51 4.56e-07 3.315e-05
65 OUTFLOW TRACT MORPHOGENESIS 4 56 6.673e-07 4.705e-05
66 REGULATION OF CELL PROLIFERATION 11 1496 6.603e-07 4.705e-05
67 NEGATIVE REGULATION OF NERVOUS SYSTEM DEVELOPMENT 6 262 6.859e-07 4.763e-05
68 CELL ACTIVATION INVOLVED IN IMMUNE RESPONSE 5 139 7.166e-07 4.904e-05
69 N TERMINAL PROTEIN AMINO ACID ACETYLATION 3 15 7.773e-07 5.241e-05
70 CARDIAC CHAMBER DEVELOPMENT 5 144 8.538e-07 5.675e-05
71 REGULATION OF BINDING 6 283 1.075e-06 7.047e-05
72 VASCULATURE DEVELOPMENT 7 469 1.243e-06 8.034e-05
73 IMMUNE SYSTEM PROCESS 12 1984 1.33e-06 8.365e-05
74 ANGIOGENESIS 6 293 1.316e-06 8.365e-05
75 NEURON FATE COMMITMENT 4 67 1.38e-06 8.56e-05
76 RHYTHMIC PROCESS 6 298 1.452e-06 8.889e-05
77 NEGATIVE REGULATION OF CELL DEVELOPMENT 6 303 1.599e-06 9.514e-05
78 NEGATIVE REGULATION OF MULTICELLULAR ORGANISMAL PROCESS 9 983 1.615e-06 9.514e-05
79 IMMUNE EFFECTOR PROCESS 7 486 1.576e-06 9.514e-05
80 SKIN EPIDERMIS DEVELOPMENT 4 71 1.743e-06 0.0001014
81 ENDOTHELIAL CELL DIFFERENTIATION 4 72 1.844e-06 0.0001055
82 RESPONSE TO OXYGEN LEVELS 6 311 1.86e-06 0.0001055
83 NEGATIVE REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 8 740 2.091e-06 0.0001172
84 ARTERY DEVELOPMENT 4 75 2.173e-06 0.0001204
85 MEMBRANE PROTEIN ECTODOMAIN PROTEOLYSIS 3 22 2.616e-06 0.0001415
86 AORTA MORPHOGENESIS 3 22 2.616e-06 0.0001415
87 POSITIVE REGULATION OF MULTICELLULAR ORGANISMAL PROCESS 10 1395 3.27e-06 0.0001749
88 ANTERIOR POSTERIOR PATTERN SPECIFICATION 5 194 3.701e-06 0.0001957
89 EMBRYO DEVELOPMENT ENDING IN BIRTH OR EGG HATCHING 7 554 3.752e-06 0.0001962
90 EAR DEVELOPMENT 5 195 3.795e-06 0.0001962
91 TISSUE REMODELING 4 87 3.94e-06 0.0002015
92 N TERMINAL PROTEIN AMINO ACID MODIFICATION 3 26 4.401e-06 0.0002226
93 BLOOD VESSEL MORPHOGENESIS 6 364 4.61e-06 0.0002306
94 NEURON DIFFERENTIATION 8 874 7.174e-06 0.0003551
95 REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER IN RESPONSE TO HYPOXIA 3 32 8.355e-06 0.000405
96 BLOOD VESSEL REMODELING 3 32 8.355e-06 0.000405
97 MEMBRANE PROTEIN PROTEOLYSIS 3 35 1.1e-05 0.0005275
98 REGULATION OF EMBRYONIC DEVELOPMENT 4 114 1.155e-05 0.0005482
99 EPIDERMIS DEVELOPMENT 5 253 1.345e-05 0.0006321
100 POSITIVE REGULATION OF BINDING 4 127 1.769e-05 0.0008211
101 AORTA DEVELOPMENT 3 41 1.782e-05 0.0008211
102 MAINTENANCE OF CELL NUMBER 4 132 2.059e-05 0.0009306
103 BETA CATENIN TCF COMPLEX ASSEMBLY 3 43 2.06e-05 0.0009306
104 EPITHELIAL CELL DIFFERENTIATION 6 495 2.646e-05 0.001184
105 EPIDERMAL CELL DIFFERENTIATION 4 142 2.744e-05 0.001216
106 CARDIAC SEPTUM MORPHOGENESIS 3 49 3.06e-05 0.001343
107 REGULATION OF MUSCLE CELL DIFFERENTIATION 4 152 3.582e-05 0.001558
108 IMMUNE RESPONSE 8 1100 3.81e-05 0.001641
109 REGULATION OF CELL DEATH 9 1472 4.28e-05 0.001827
110 POSITIVE REGULATION OF CELL PROLIFERATION 7 814 4.555e-05 0.00191
111 EYE DEVELOPMENT 5 326 4.534e-05 0.00191
112 POSITIVE REGULATION OF CELL DIFFERENTIATION 7 823 4.886e-05 0.00203
113 POSITIVE REGULATION OF DEVELOPMENTAL PROCESS 8 1142 4.979e-05 0.00205
114 REGULATION OF PROTEIN BINDING 4 168 5.294e-05 0.002161
115 REGULATION OF CYTOKINE PRODUCTION 6 563 5.436e-05 0.002162
116 APPENDAGE DEVELOPMENT 4 169 5.418e-05 0.002162
117 LIMB DEVELOPMENT 4 169 5.418e-05 0.002162
118 REGULATION OF PROTEIN TYROSINE KINASE ACTIVITY 3 61 5.919e-05 0.002301
119 EMBRYONIC DIGIT MORPHOGENESIS 3 61 5.919e-05 0.002301
120 COVALENT CHROMATIN MODIFICATION 5 345 5.934e-05 0.002301
121 CARDIAC VENTRICLE MORPHOGENESIS 3 62 6.215e-05 0.00239
122 REGULATION OF PROTEIN ACETYLATION 3 64 6.835e-05 0.002607
123 NEGATIVE REGULATION OF CELL DEATH 7 872 7.049e-05 0.002667
124 REGULATION OF DNA TEMPLATED TRANSCRIPTION IN RESPONSE TO STRESS 3 67 7.84e-05 0.002942
125 LOOP OF HENLE DEVELOPMENT 2 11 8.194e-05 0.002979
126 POSITIVE REGULATION OF RECEPTOR BIOSYNTHETIC PROCESS 2 11 8.194e-05 0.002979
127 VENTRICULAR TRABECULA MYOCARDIUM MORPHOGENESIS 2 11 8.194e-05 0.002979
128 ENDOTHELIAL TUBE MORPHOGENESIS 2 11 8.194e-05 0.002979
129 CELL FATE SPECIFICATION 3 71 9.323e-05 0.003363
130 REGULATION OF TIMING OF CELL DIFFERENTIATION 2 12 9.825e-05 0.003463
131 AMYLOID PRECURSOR PROTEIN METABOLIC PROCESS 2 12 9.825e-05 0.003463
132 REGULATION OF DEVELOPMENT HETEROCHRONIC 2 12 9.825e-05 0.003463
133 POSITIVE REGULATION OF PROTEIN BINDING 3 73 0.0001013 0.003543
134 EYELID DEVELOPMENT IN CAMERA TYPE EYE 2 13 0.000116 0.004029
135 EMBRYONIC ORGAN DEVELOPMENT 5 406 0.0001278 0.004405
136 REGULATION OF NEURON PROJECTION DEVELOPMENT 5 408 0.0001308 0.004474
137 REGULATION OF PEPTIDYL TYROSINE PHOSPHORYLATION 4 213 0.0001327 0.004508
138 REGULATION OF ESTABLISHMENT OF PLANAR POLARITY INVOLVED IN NEURAL TUBE CLOSURE 2 14 0.0001353 0.004528
139 BETA AMYLOID METABOLIC PROCESS 2 14 0.0001353 0.004528
140 REGULATION OF ERBB SIGNALING PATHWAY 3 83 0.0001484 0.004863
141 HAIR CYCLE 3 83 0.0001484 0.004863
142 MOLTING CYCLE 3 83 0.0001484 0.004863
143 ECTODERMAL PLACODE DEVELOPMENT 2 15 0.0001559 0.00497
144 ECTODERMAL PLACODE MORPHOGENESIS 2 15 0.0001559 0.00497
145 ECTODERMAL PLACODE FORMATION 2 15 0.0001559 0.00497
146 EPITHELIAL CELL FATE COMMITMENT 2 15 0.0001559 0.00497
147 CARDIAC SEPTUM DEVELOPMENT 3 85 0.0001593 0.005007
148 REGULATION OF STRIATED MUSCLE CELL DIFFERENTIATION 3 85 0.0001593 0.005007
149 MUSCLE STRUCTURE DEVELOPMENT 5 432 0.0001708 0.005334
150 MORPHOGENESIS OF AN ENDOTHELIUM 2 16 0.0001781 0.005524
151 POSITIVE REGULATION OF NERVOUS SYSTEM DEVELOPMENT 5 437 0.0001802 0.005553
152 POSITIVE REGULATION OF NEURON PROJECTION DEVELOPMENT 4 232 0.0001843 0.005641
153 REGULATION OF CANONICAL WNT SIGNALING PATHWAY 4 236 0.0001967 0.005945
154 POSITIVE REGULATION OF MOLECULAR FUNCTION 9 1791 0.0001967 0.005945
155 MEMBRANE PROTEIN INTRACELLULAR DOMAIN PROTEOLYSIS 2 17 0.0002017 0.006015
156 SEGMENT SPECIFICATION 2 17 0.0002017 0.006015
157 POSITIVE REGULATION OF GROWTH 4 238 0.0002032 0.006022
158 CANONICAL WNT SIGNALING PATHWAY 3 95 0.0002213 0.006519
159 CELL DEVELOPMENT 8 1426 0.0002363 0.006914
160 MEMORY 3 98 0.0002426 0.007056
161 NEURONAL STEM CELL POPULATION MAINTENANCE 2 19 0.0002532 0.007272
162 REGULATION OF PROTEIN SERINE THREONINE KINASE ACTIVITY 5 470 0.0002526 0.007272
163 POSITIVE REGULATION OF CELL DEVELOPMENT 5 472 0.0002577 0.007355
164 LEUKOCYTE CELL CELL ADHESION 4 255 0.0002644 0.007502
165 TONGUE DEVELOPMENT 2 20 0.0002811 0.007879
166 MYELOID DENDRITIC CELL DIFFERENTIATION 2 20 0.0002811 0.007879
167 CARDIAC VENTRICLE DEVELOPMENT 3 106 0.0003057 0.008518
168 REGULATION OF RECEPTOR BIOSYNTHETIC PROCESS 2 21 0.0003105 0.008548
169 COCHLEA MORPHOGENESIS 2 21 0.0003105 0.008548
170 NEGATIVE REGULATION OF GENE EXPRESSION 8 1493 0.0003237 0.00886
171 BETA CATENIN DESTRUCTION COMPLEX DISASSEMBLY 2 22 0.0003412 0.009125
172 REGULATION OF ANDROGEN RECEPTOR SIGNALING PATHWAY 2 22 0.0003412 0.009125
173 MODULATION OF TRANSCRIPTION IN OTHER ORGANISM INVOLVED IN SYMBIOTIC INTERACTION 2 22 0.0003412 0.009125
174 HISTONE H3 DEACETYLATION 2 22 0.0003412 0.009125
175 COLUMNAR CUBOIDAL EPITHELIAL CELL DIFFERENTIATION 3 111 0.0003501 0.009255
176 REGULATION OF TYPE I INTERFERON PRODUCTION 3 111 0.0003501 0.009255
177 MUSCLE TISSUE DEVELOPMENT 4 275 0.0003523 0.009261
178 MUSCLE ORGAN DEVELOPMENT 4 277 0.0003621 0.009366
179 NEGATIVE REGULATION OF NITROGEN COMPOUND METABOLIC PROCESS 8 1517 0.0003609 0.009366
180 POSITIVE REGULATION OF PROTEIN MODIFICATION PROCESS 7 1135 0.0003623 0.009366
181 REGULATION OF EPIDERMAL GROWTH FACTOR ACTIVATED RECEPTOR ACTIVITY 2 23 0.0003735 0.009444
182 POSITIVE REGULATION OF MULTICELLULAR ORGANISMAL METABOLIC PROCESS 2 23 0.0003735 0.009444
183 EMBRYONIC ORGAN MORPHOGENESIS 4 279 0.0003721 0.009444
184 POSITIVE REGULATION OF COLLAGEN METABOLIC PROCESS 2 23 0.0003735 0.009444
185 NEPHRON DEVELOPMENT 3 115 0.0003884 0.009769
NumGOOverlapSizeP ValueAdj. P Value
1 NOTCH BINDING 5 18 1.69e-11 1.57e-08
2 RNA POLYMERASE II TRANSCRIPTION FACTOR BINDING 5 104 1.688e-07 7.84e-05
3 TRANSCRIPTION FACTOR BINDING 7 524 2.598e-06 0.0008044
4 RNA POLYMERASE II REPRESSING TRANSCRIPTION FACTOR BINDING 3 27 4.947e-06 0.001032
5 TRANSCRIPTION FACTOR ACTIVITY PROTEIN BINDING 7 588 5.553e-06 0.001032
6 NF KAPPAB BINDING 3 30 6.85e-06 0.001061
7 CHROMATIN BINDING 6 435 1.275e-05 0.001692
8 TRANSCRIPTION COACTIVATOR ACTIVITY 5 296 2.861e-05 0.003322
9 CORE PROMOTER BINDING 4 152 3.582e-05 0.003698
10 ACTIVATING TRANSCRIPTION FACTOR BINDING 3 57 4.828e-05 0.003738
11 REPRESSING TRANSCRIPTION FACTOR BINDING 3 57 4.828e-05 0.003738
12 RECEPTOR BINDING 9 1476 4.373e-05 0.003738
13 PEPTIDE N ACETYLTRANSFERASE ACTIVITY 3 67 7.84e-05 0.005552
14 CORE PROMOTER PROXIMAL REGION DNA BINDING 5 371 8.366e-05 0.005552
15 HISTONE DEACETYLASE ACTIVITY H3 K14 SPECIFIC 2 12 9.825e-05 0.006085
16 CHROMATIN DNA BINDING 3 80 0.000133 0.007724
17 BETA CATENIN BINDING 3 84 0.0001538 0.008049
18 PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR BINDING 2 15 0.0001559 0.008049
19 CALCIUM ION BINDING 6 697 0.0001761 0.008178
20 N ACETYLTRANSFERASE ACTIVITY 3 87 0.0001706 0.008178
21 NAD DEPENDENT PROTEIN DEACETYLASE ACTIVITY 2 17 0.0002017 0.008922
NumGOOverlapSizeP ValueAdj. P Value
1 CHROMOSOME 8 880 7.544e-06 0.003461
2 CHROMATIN 6 441 1.378e-05 0.003461
3 GOLGI MEMBRANE 7 703 1.778e-05 0.003461
4 NUCLEAR CHROMATIN 5 291 2.636e-05 0.003849
5 APICAL PART OF CELL 5 361 7.354e-05 0.007973
6 GOLGI APPARATUS PART 7 893 8.191e-05 0.007973
7 SIN3 COMPLEX 2 13 0.000116 0.00968

Over-represented Pathway

NumPathwayPathviewOverlapSizeP ValueAdj. P Value
1 hsa04330_Notch_signaling_pathway 25 47 6.961e-70 1.253e-67
2 hsa04310_Wnt_signaling_pathway 5 151 1.08e-06 9.717e-05
3 hsa04320_Dorso.ventral_axis_formation 3 25 3.897e-06 0.0002338
4 hsa04916_Melanogenesis 4 101 7.143e-06 0.0003214
5 hsa04110_Cell_cycle 4 128 1.824e-05 0.0006568
6 hsa00514_Other_types_of_O.glycan_biosynthesis 2 46 0.001501 0.04503
7 hsa04720_Long.term_potentiation 2 70 0.003439 0.08401
8 hsa04520_Adherens_junction 2 73 0.003734 0.08401
9 hsa04350_TGF.beta_signaling_pathway 2 85 0.005026 0.1005
10 hsa04722_Neurotrophin_signaling_pathway 2 127 0.01091 0.1964
11 hsa04390_Hippo_signaling_pathway 2 154 0.01574 0.2389
12 hsa04630_Jak.STAT_signaling_pathway 2 155 0.01593 0.2389

lncRNA-mediated sponge

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Num lncRNA miRNAs           miRNAs count     Gene Sponge regulatory network lncRNA log2FC lncRNA pvalue Gene log2FC Gene pvalue lncRNA-gene Pearson correlation
1

EMX2OS

 hsa-miR-106a-5p;hsa-miR-130b-5p;hsa-miR-148a-5p;hsa-miR-15a-5p;hsa-miR-15b-5p;hsa-miR-16-1-3p;hsa-miR-16-5p;hsa-miR-17-5p;hsa-miR-183-5p;hsa-miR-186-5p;hsa-miR-18a-3p;hsa-miR-196a-5p;hsa-miR-200a-5p;hsa-miR-200b-5p;hsa-miR-25-3p;hsa-miR-29a-3p;hsa-miR-29b-3p;hsa-miR-374b-5p;hsa-miR-421;hsa-miR-424-5p;hsa-miR-590-3p;hsa-miR-92a-3p;hsa-miR-940;hsa-miR-942-5p 24 NOTCH2 Sponge network 1.057 0.31716 -0.29 0.84538 0.348
2

CECR7

 hsa-miR-106a-5p;hsa-miR-130b-5p;hsa-miR-148a-5p;hsa-miR-15a-5p;hsa-miR-15b-5p;hsa-miR-16-1-3p;hsa-miR-16-5p;hsa-miR-17-5p;hsa-miR-183-5p;hsa-miR-186-5p;hsa-miR-18a-3p;hsa-miR-196a-5p;hsa-miR-200a-5p;hsa-miR-200b-5p;hsa-miR-25-3p;hsa-miR-29a-3p;hsa-miR-29b-3p;hsa-miR-30b-5p;hsa-miR-30c-5p;hsa-miR-429;hsa-miR-590-3p;hsa-miR-590-5p;hsa-miR-942-5p 23 NOTCH2 Sponge network 0.551 0.56177 -0.29 0.84538 0.286

Quest ID: 63d90c2ae42ca034c2d4017c37070d01