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This regulatory network was inferred from the input dataset. The miRNAs and mRNAs are presented as round and rectangle nodes respectively. The numerical value popped up upon mouse over the gene node is the log2 transformed fold-change of the gene expression between the two groups. All of the nodes are clickable, and the detailed information of the miRNAs/mRNAs and related cancer pathway will be displayed in another window. The edges between nodes are supported by both interactions (predicted or experimentally verified) and correlations learnt from cancer dataset. The numerical value popped up upon mouse over the edge is the correlation beat value (effect size) between the two nodes. The experimental evidences of the edges reported in previous cancer studies are highlighted by red/orange color. All of these information can be accessed by the "mouse-over" action. This network shows a full map of the miRNA-mRNA regulation of the input gene list(s), and the hub miRNAs (with the high network degree/betweenness centrality) would be the potential cancer drivers or tumor suppressors. The full result table can be accessed in the "Regulations" tab.

"miRNACancerMAP" is also a network visualization tool for users to draw their regulatory network by personal customization. Users can set the complexity of the network by limiting the number of nodes or edges. And the color of the nodes can be defined by different categories of the mRNAs and miRNAs, such as Gene-Ontology, pathway, and expression status. Users can also select to use network degree or network betweenness centrality to define the node size. And edges can be black or colored by the correlation. Purple edge means negative correlation (mostly found between miRNA and mRNA), and blue edge means positive correlation (found in PPI or miRNA-miRNA sponge effect). We can also add the protein-protein interactions (PPI) into the network. This result will show the cluster of genes regulated by some specific miRNAs. Additionally, miRNA-miRNA edges can be added by the "miRNA sponge" button, presenting some clusters of miRNAs that have the interactions via sponge effect.

miRNA-gene regulations

(Download full result)

Num microRNA           Gene miRNA log2FC miRNA pvalue Gene log2FC Gene pvalue Interaction Correlation beta Correlation P-value PMID Reported in cancer studies
1 hsa-miR-122-5p ADAM17 -1.24 0 0.08 0.57225 miRNAWalker2 validate; miRTarBase -0.19 0 19296470 We further showed that one of the miR-122 targets ADAM17 a disintegrin and metalloprotease 17 is involved in metastasis; Silencing of ADAM17 resulted in a dramatic reduction of in vitro migration invasion in vivo tumorigenesis angiogenesis and local invasion in the livers of nude mice which is similar to that which occurs with the restoration of miR-122; Our study suggests that miR-122 a tumor suppressor microRNA affecting hepatocellular carcinoma intrahepatic metastasis by angiogenesis suppression exerts some of its action via regulation of ADAM17; Using the concomitant down-regulation of its targets including ADAM17 a rational therapeutic strategy based on miR-122 may prove to be beneficial for patients with hepatocellular carcinoma
2 hsa-miR-145-5p APH1A -1.48 0 0.33 1.0E-5 miRNAWalker2 validate -0.1 0 NA
3 hsa-miR-1976 APH1A -0.43 0.00325 0.33 1.0E-5 MirTarget -0.13 0 NA
4 hsa-miR-2355-5p APH1A -0.23 0.15791 0.33 1.0E-5 MirTarget -0.1 0 NA
5 hsa-miR-342-3p APH1A -0.32 0.04498 0.33 1.0E-5 miRanda -0.13 0 NA
6 hsa-miR-582-5p APH1A -0.68 0.00104 0.33 1.0E-5 PITA -0.12 0 NA
7 hsa-miR-324-3p CREBBP 0.26 0.05061 -0.2 0.01387 miRNAWalker2 validate -0.12 3.0E-5 NA
8 hsa-miR-330-5p CREBBP 0.44 0.00533 -0.2 0.01387 miRanda -0.11 1.0E-5 NA
9 hsa-miR-769-5p CREBBP 0.22 0.03334 -0.2 0.01387 miRNAWalker2 validate -0.13 0.00077 NA
10 hsa-miR-146b-5p CTBP2 0.42 0.04574 -0.39 0.02251 miRanda -0.18 1.0E-5 NA
11 hsa-miR-616-5p CTBP2 0.15 0.40284 -0.39 0.02251 mirMAP -0.31 0 NA
12 hsa-miR-618 CTBP2 0.14 0.51715 -0.39 0.02251 MirTarget; PITA -0.33 0 NA
13 hsa-miR-103a-3p DLL1 0.77 0 -0.55 0.01603 miRNATAP -0.51 0 NA
14 hsa-miR-107 DLL1 0.24 0.01708 -0.55 0.01603 PITA; miRanda; miRNATAP -0.62 0 NA
15 hsa-miR-130b-3p DLL1 0.69 0.00011 -0.55 0.01603 miRNATAP -0.21 0.00085 NA
16 hsa-miR-146b-5p DLL1 0.42 0.04574 -0.55 0.01603 miRanda -0.18 0.00088 NA
17 hsa-miR-15a-5p DLL1 0.35 0.00077 -0.55 0.01603 miRNATAP -0.37 0.00062 NA
18 hsa-miR-15b-5p DLL1 0.23 0.08248 -0.55 0.01603 miRNATAP -0.35 3.0E-5 NA
19 hsa-miR-301a-3p DLL1 0.84 0 -0.55 0.01603 miRNATAP -0.26 4.0E-5 NA
20 hsa-miR-423-3p DLL1 0.3 0.00067 -0.55 0.01603 PITA -0.61 0 NA
21 hsa-miR-454-3p DLL1 0.67 0 -0.55 0.01603 miRNATAP -0.21 0.00766 NA
22 hsa-miR-589-5p DLL1 1.19 0 -0.55 0.01603 miRNATAP -0.63 0 NA
23 hsa-miR-29a-5p DLL4 -0.11 0.34962 1.07 0 miRNATAP -0.21 0.00016 NA
24 hsa-miR-30c-5p DLL4 -0.43 0.00016 1.07 0 miRNATAP -0.17 0.00359 NA
25 hsa-miR-424-5p DLL4 -2.63 0 1.07 0 miRNATAP -0.13 0.0002 NA
26 hsa-miR-188-5p DTX1 1.12 0 -2.8 0 PITA -0.32 0.0009 NA
27 hsa-miR-421 DTX1 0.94 0 -2.8 0 PITA; miRanda; miRNATAP -0.35 0.00027 NA
28 hsa-let-7a-5p DTX2 -0.33 0.00046 0.39 0 TargetScan; miRNATAP -0.23 0 NA
29 hsa-let-7b-5p DTX2 -0.96 0 0.39 0 miRNATAP -0.12 1.0E-5 NA
30 hsa-let-7g-5p DTX2 -0.46 2.0E-5 0.39 0 miRNATAP -0.2 0 NA
31 hsa-miR-107 DTX3 0.24 0.01708 0.08 0.67413 miRanda -0.29 0.00171 NA
32 hsa-miR-148a-5p DTX3 -0.77 0 0.08 0.67413 mirMAP -0.35 0 NA
33 hsa-miR-339-5p DTX3L 0.28 0.03557 -0.19 0.02216 miRanda -0.1 0.00089 NA
34 hsa-miR-340-3p DTX3L -0.33 0.0033 -0.19 0.02216 MirTarget -0.11 0.00292 NA
35 hsa-miR-140-3p DTX4 0.55 0 -0.32 0.16271 miRNATAP -0.43 0.0011 NA
36 hsa-miR-204-5p DTX4 -0.54 0.03309 -0.32 0.16271 miRNATAP -0.29 0 NA
37 hsa-miR-29a-5p DTX4 -0.11 0.34962 -0.32 0.16271 mirMAP -0.46 0 NA
38 hsa-miR-29b-3p DTX4 -0.35 0.01214 -0.32 0.16271 miRNATAP -0.26 0.00109 NA
39 hsa-miR-374a-5p DTX4 0.02 0.86978 -0.32 0.16271 mirMAP -0.8 0 NA
40 hsa-miR-374b-5p DTX4 -0.31 0.00301 -0.32 0.16271 mirMAP -0.62 0 NA
41 hsa-miR-548b-3p DTX4 -0.02 0.93082 -0.32 0.16271 PITA; mirMAP; miRNATAP -0.19 9.0E-5 NA
42 hsa-miR-10a-5p DVL1 -1.48 0 0.1 0.35133 miRNAWalker2 validate -0.12 0 NA
43 hsa-miR-27a-3p DVL2 -0.37 0.00876 0.93 0 miRNATAP -0.1 0.00527 NA
44 hsa-miR-27b-3p DVL2 -0.82 0 0.93 0 miRNATAP -0.22 0 NA
45 hsa-miR-125b-5p DVL3 -1.36 0 0.61 0 miRNATAP -0.13 0 NA
46 hsa-miR-26b-5p DVL3 -1.11 0 0.61 0 miRNAWalker2 validate -0.11 0.00053 NA
47 hsa-miR-29b-2-5p DVL3 -0.22 0.08431 0.61 0 MirTarget -0.1 0.00053 NA
48 hsa-miR-339-5p EP300 0.28 0.03557 -0.2 0.07049 miRanda -0.16 0.0001 NA
49 hsa-miR-342-3p EP300 -0.32 0.04498 -0.2 0.07049 MirTarget; PITA; miRanda; miRNATAP -0.11 0.00085 NA
50 hsa-miR-30a-5p HDAC1 -0.63 0.00011 0.31 0.00015 miRNAWalker2 validate -0.15 0 NA
51 hsa-let-7b-3p HDAC2 -1.22 0 0.16 0.06327 mirMAP -0.12 1.0E-5 NA
52 hsa-miR-125b-2-3p HDAC2 -1.66 0 0.16 0.06327 mirMAP -0.1 0 NA
53 hsa-miR-16-1-3p JAG1 0.39 0.00112 0.28 0.09623 MirTarget -0.26 0.00018 NA
54 hsa-miR-186-5p JAG1 -0.06 0.53529 0.28 0.09623 MirTarget; miRNATAP -0.3 0.00055 NA
55 hsa-miR-26b-3p JAG1 -1.26 0 0.28 0.09623 miRNATAP -0.27 5.0E-5 NA
56 hsa-miR-26b-5p JAG1 -1.11 0 0.28 0.09623 MirTarget; miRNATAP -0.2 0.00313 NA
57 hsa-miR-34a-5p JAG1 1.04 0 0.28 0.09623 miRNAWalker2 validate; miRTarBase; MirTarget; miRNATAP -0.19 0.00096 NA
58 hsa-miR-361-3p JAG1 0.28 0.00549 0.28 0.09623 miRNATAP -0.24 0.00533 NA
59 hsa-miR-590-5p JAG1 -0.1 0.31003 0.28 0.09623 MirTarget; PITA; miRanda; miRNATAP -0.31 0.00018 NA
60 hsa-miR-140-5p JAG2 -0.22 0.01407 1.64 0 miRanda -0.37 0.00048 NA
61 hsa-miR-3607-3p JAG2 -2.16 0 1.64 0 miRNATAP -0.24 0 NA
62 hsa-miR-505-3p JAG2 -1.2 0 1.64 0 mirMAP -0.33 0 NA
63 hsa-miR-342-3p KAT2A -0.32 0.04498 1.46 0 MirTarget; miRanda -0.12 0.00265 NA
64 hsa-miR-106a-5p KAT2B -0.46 0.00972 -0.94 0 MirTarget -0.18 1.0E-5 NA
65 hsa-miR-106b-5p KAT2B 0.65 0 -0.94 0 miRNAWalker2 validate; miRTarBase; MirTarget -0.52 0 NA
66 hsa-miR-125a-3p KAT2B -0.84 4.0E-5 -0.94 0 miRanda -0.15 4.0E-5 NA
67 hsa-miR-17-5p KAT2B 0.7 2.0E-5 -0.94 0 MirTarget; TargetScan -0.4 0 23095762 miR 17 5p targets the p300/CBP associated factor and modulates androgen receptor transcriptional activity in cultured prostate cancer cells; Targeting of PCAF by miR-17-5p was evaluated using the luciferase reporter assay; Expression of PCAF in PCa cells was associated with the downregulation of miR-17-5p; Targeting of the 3'-untranslated region of PCAF mRNA by miR-17-5p caused translational suppression and RNA degradation and consequently modulation of AR transcriptional activity in PCa cells; PCAF is upregulated in cultured PCa cells and upregulation of PCAF is associated with the downregulation of miR-17-5p; Targeting of PCAF by miR-17-5p modulates AR transcriptional activity and cell growth in cultured PCa cells
68 hsa-miR-181a-5p KAT2B 0.25 0.05519 -0.94 0 miRNAWalker2 validate; miRTarBase; MirTarget -0.43 0 NA
69 hsa-miR-181b-5p KAT2B 0.49 0.00105 -0.94 0 miRNAWalker2 validate; miRTarBase; MirTarget -0.46 0 NA
70 hsa-miR-181c-5p KAT2B -0.01 0.96913 -0.94 0 MirTarget -0.27 0 NA
71 hsa-miR-181d-5p KAT2B 0.16 0.36381 -0.94 0 MirTarget -0.28 0 NA
72 hsa-miR-19a-3p KAT2B 1.02 0 -0.94 0 miRNAWalker2 validate -0.26 0 NA
73 hsa-miR-19b-3p KAT2B 0.6 0.00017 -0.94 0 miRNAWalker2 validate -0.3 0 NA
74 hsa-miR-20a-3p KAT2B -0.32 0.04679 -0.94 0 MirTarget -0.22 0 NA
75 hsa-miR-20a-5p KAT2B 0.85 0 -0.94 0 MirTarget -0.32 0 NA
76 hsa-miR-20b-5p KAT2B 0.46 0.02859 -0.94 0 MirTarget -0.11 0.00122 NA
77 hsa-miR-25-3p KAT2B 0.63 0 -0.94 0 miRNAWalker2 validate; miRTarBase; MirTarget -0.26 0.00023 NA
78 hsa-miR-330-3p KAT2B -0.33 0.03161 -0.94 0 MirTarget -0.27 0 NA
79 hsa-miR-338-5p KAT2B -0.22 0.25239 -0.94 0 MirTarget; miRNATAP -0.15 7.0E-5 NA
80 hsa-miR-342-3p KAT2B -0.32 0.04498 -0.94 0 miRanda -0.18 7.0E-5 NA
81 hsa-miR-363-3p KAT2B -0.17 0.37519 -0.94 0 MirTarget -0.1 0.00633 NA
82 hsa-miR-429 KAT2B -1.4 7.0E-5 -0.94 0 miRanda -0.13 0 NA
83 hsa-miR-590-5p KAT2B -0.1 0.31003 -0.94 0 miRanda -0.26 0.0004 NA
84 hsa-miR-92a-3p KAT2B 0.21 0.13429 -0.94 0 miRNAWalker2 validate; MirTarget -0.35 0 NA
85 hsa-miR-92b-3p KAT2B 0.22 0.29619 -0.94 0 MirTarget -0.23 0 NA
86 hsa-miR-93-5p KAT2B 1.4 0 -0.94 0 miRNAWalker2 validate; miRTarBase; MirTarget -0.38 0 NA
87 hsa-miR-107 LFNG 0.24 0.01708 0.26 0.14017 miRanda -0.36 3.0E-5 NA
88 hsa-miR-365a-3p LFNG 0.16 0.15325 0.26 0.14017 mirMAP -0.45 0 NA
89 hsa-miR-219a-5p MFNG 0.18 0.32269 -0.41 0.0014 MirTarget -0.14 0.00012 NA
90 hsa-miR-28-5p MFNG -0.43 0 -0.41 0.0014 miRanda -0.25 0.00032 NA
91 hsa-miR-29a-3p NCOR2 -0.86 0 0.53 0 miRNATAP -0.15 0 NA
92 hsa-miR-29b-3p NCOR2 -0.35 0.01214 0.53 0 miRNATAP -0.13 1.0E-5 NA
93 hsa-miR-29c-3p NCOR2 -1.44 0 0.53 0 miRNATAP -0.16 0 NA
94 hsa-miR-3607-3p NCOR2 -2.16 0 0.53 0 miRNATAP -0.14 0 NA
95 hsa-miR-101-3p NOTCH1 -1.48 0 -0.03 0.79556 MirTarget -0.13 0.00575 NA
96 hsa-miR-34a-5p NOTCH1 1.04 0 -0.03 0.79556 miRNAWalker2 validate; miRTarBase; MirTarget; miRNATAP -0.24 0 22438124; 23140286; 24349627; 24565525; 25783790; 20351093; 27082152; 23642368; 22347519; 23430952; 23902763; 21743299; 22992310; 23145211; 25623761; 23085450 Delta tocotrienol suppresses Notch 1 pathway by upregulating miR 34a in nonsmall cell lung cancer cells; In our study using miRNA microarray we observed that downregulation of the Notch-1 pathway by delta-tocotrienol correlated with upregulation of miR-34a in nonsmall cell lung cancer cells NSCLC;We found that Re-expression forced expression of miR-34a inhibits cell growth and induces apoptosis with concomitant down-regulation of Notch-1 signaling pathway one of the target of miR-34a; Moreover treatment of PC cells with a natural compound genistein led to the up-regulation of miR-34a resulting in the down-regulation of Notch-1 which was correlated with inhibition of cell growth and induction of apoptosis;Most importantly BR-DIM intervention in PCa patients prior to radical prostatectomy showed reexpression of miR-34a which was consistent with decreased expression of AR PSA and Notch-1 in PCa tissue specimens;In addition intracellular restoration of miR-34a inhibited breast cancer cell migration via targeting Notch-1 signaling;MicroRNA 34a suppresses the breast cancer stem cell like characteristics by downregulating Notch1 pathway; In this study we verified that miR-34a directly and functionally targeted Notch1 in MCF-7 cells; We reported that miR-34a negatively regulated cell proliferation migration and invasion and breast cancer stem cell propagation by downregulating Notch1; The expression of miR-34a was negatively correlated with tumor stages metastasis and Notch1 expression in breast cancer tissues; Furthermore overexpression of miR-34a increased chemosensitivity of breast cancer cells to paclitaxel PTX by downregulating the Notch1 pathway; Taken together our results indicate that miR-34a inhibited breast cancer stemness and increased the chemosensitivity to PTX partially by downregulating the Notch1 pathway suggesting that miR-34a/Notch1 play an important role in regulating breast cancer stem cells;MicroRNA 34a suppresses invasion through downregulation of Notch1 and Jagged1 in cervical carcinoma and choriocarcinoma cells; Computational miRNA target prediction suggested that Notch1 and Jagged1 were targets of miR-34a; By using functional assays miR-34a was demonstrated to bind to the 3' untranslated regions of Notch1 and Jagged1; Forced expression of miR-34a altered the expression of Notch1 and Jagged1 protein as well as Notch signaling as shown by the response of Hairy Enhancer of Split-1 protein to these treatments using western blot analysis;We showed that miR-34a as a tumor suppressor could separately reduce the stemness of BCSCs and activate the cytotoxic susceptibility of BCSCs to natural killer NK cells in vitro via down regulating the expression of Notch1 signaling molecules;Mechanistically miR-34a sequesters Notch1 mRNA to generate a sharp threshold response where a bimodal Notch signal specifies the choice between self-renewal and differentiation;Most importantly BR-DIM intervention in PCa patients prior to radical prostatectomy showed re-expression of miR-34a which was consistent with decreased expression of AR PSA and Notch-1 in PCa tissue specimens;We also found that reexpression of miR-34a and miR-200b by transfection led to reduced expression of Notch-1 resulting in the inhibition of osteosarcoma cell proliferation invasion and angiogenesis;Rhamnetin and cirsiliol induce radiosensitization and inhibition of epithelial mesenchymal transition EMT by miR 34a mediated suppression of Notch 1 expression in non small cell lung cancer cell lines; Indeed rhamnetin and cirsiliol increased the expression of tumor-suppressive microRNA miR-34a in a p53-dependent manner leading to inhibition of Notch-1 expression;MicroRNA 34a targets notch1 and inhibits cell proliferation in glioblastoma multiforme; Also we identified notch1 as a direct target gene of miR-34a; Knockdown of notch1 showed similar cellular functions as overexpression of miR-34a both in vitro and in vivo; Collectively our findings show that miR-34a is downregulated in GBM cells and inhibits GBM growth by targeting notch1;The re-expression of miR-34 led to a marked reduction in the expression of its target gene Notch-1;Inactivation of AR and Notch 1 signaling by miR 34a attenuates prostate cancer aggressiveness; We found that over-expression of miR-34a led to reduced expression of AR PSA and Notch-1; These findings suggest that the loss of miR-34a is directly linked with up-regulation of AR and Notch-1 both of which are highly expressed in PCa and thus finding innovative approaches by which miR-34a expression could be up-regulated will have a huge impact on the treatment of PCa especially for the treatment of mCRPC;miR 34a may regulate sensitivity of breast cancer cells to adriamycin via targeting Notch1; To explore the influence of miR-34a on Notch1 expression in breast cancer cells and to explore the role of miR-34a in the sensitivity of breast cancer cells to Adriamycin ADR; The expression levels of Notch1 mRNA and protein in MCF-7/ADR cells transfected with miR-34a mimics were significantly up-regulated; On the contrary the expressions of Notch1 mRNA and protein in MCF-7 cells transfected with miR-34a inhibitor were down-regulated; miR-34a negatively regulates the expression of Notch1 at both mRNA and protein levels;MicroRNA 34a modulates chemosensitivity of breast cancer cells to adriamycin by targeting Notch1; The association of miR-34a and Notch1 was analyzed by dual-luciferase reporter assay and Notch1-siRNA technology; Real-time PCR assay was performed to test the expression of miR-34a and Notch1 in 38 selective breast cancer tissue samples; MiR-34a mimic could inhibit the luciferase activity of the construct containing wild-type 3' UTR of Notch1 in MCF-7/ADR cells; Further there was an inverse association between Notch1 and miR-34a expression in breast cancer; Dysregulation of miR-34a plays critical roles in the acquired ADR resistance of breast cancer at least in part via targeting Notch1
97 hsa-miR-103a-3p NOTCH2 0.77 0 -0.38 0.00411 MirTarget -0.2 0.00055 NA
98 hsa-miR-107 NOTCH2 0.24 0.01708 -0.38 0.00411 miRNAWalker2 validate; MirTarget; miRanda; miRNATAP -0.21 0.001 NA
99 hsa-miR-146b-5p NOTCH2 0.42 0.04574 -0.38 0.00411 miRanda -0.14 1.0E-5 NA
100 hsa-miR-148a-5p NOTCH2 -0.77 0 -0.38 0.00411 MirTarget -0.12 0.00236 NA
101 hsa-miR-15a-5p NOTCH2 0.35 0.00077 -0.38 0.00411 MirTarget -0.21 0.00076 NA
102 hsa-miR-16-1-3p NOTCH2 0.39 0.00112 -0.38 0.00411 mirMAP -0.17 0.00213 NA
103 hsa-miR-17-5p NOTCH2 0.7 2.0E-5 -0.38 0.00411 miRNAWalker2 validate -0.11 0.00704 NA
104 hsa-miR-29b-3p NOTCH2 -0.35 0.01214 -0.38 0.00411 MirTarget -0.17 0.00018 NA
105 hsa-miR-34a-5p NOTCH2 1.04 0 -0.38 0.00411 miRNAWalker2 validate; miRNATAP -0.21 0 NA
106 hsa-miR-374a-5p NOTCH2 0.02 0.86978 -0.38 0.00411 mirMAP -0.18 0.00666 NA
107 hsa-miR-324-5p NOTCH4 0.37 0.00592 0.46 0.00012 miRanda -0.18 4.0E-5 NA
108 hsa-miR-421 NOTCH4 0.94 0 0.46 0.00012 miRanda -0.14 3.0E-5 NA
109 hsa-miR-330-5p NUMB 0.44 0.00533 -0.37 0 miRanda -0.1 1.0E-5 NA
110 hsa-miR-339-5p NUMB 0.28 0.03557 -0.37 0 miRanda -0.13 0 NA
111 hsa-miR-589-5p NUMB 1.19 0 -0.37 0 miRNATAP -0.11 0.00016 NA
112 hsa-miR-590-5p NUMB -0.1 0.31003 -0.37 0 miRanda -0.11 0.00174 NA
113 hsa-miR-122-5p NUMBL -1.24 0 0.39 0.00366 miRNAWalker2 validate; miRTarBase -0.21 0 NA
114 hsa-miR-194-3p NUMBL -0.77 3.0E-5 0.39 0.00366 MirTarget -0.29 0 NA
115 hsa-miR-374b-5p NUMBL -0.31 0.00301 0.39 0.00366 miRNATAP -0.17 0.00846 NA
116 hsa-miR-30c-5p PSEN2 -0.43 0.00016 0.39 0.00069 miRNATAP -0.19 0.00011 NA
117 hsa-miR-421 PSEN2 0.94 0 0.39 0.00069 miRanda -0.11 0.00061 NA
118 hsa-miR-576-5p RBPJ -0.38 0.00471 0.08 0.47404 mirMAP -0.16 2.0E-5 NA
119 hsa-miR-616-5p RBPJ 0.15 0.40284 0.08 0.47404 MirTarget -0.14 0 NA
120 hsa-miR-664a-3p RBPJ 0.49 0.00073 0.08 0.47404 mirMAP -0.15 1.0E-5 NA

Over-represented Gene Ontology Biological Process

NumGOOverlapSizeP ValueAdj. P Value
1 NOTCH SIGNALING PATHWAY 18 114 1.916e-33 8.917e-30
2 NOTCH RECEPTOR PROCESSING 8 16 1.588e-19 3.695e-16
3 REGULATION OF NOTCH SIGNALING PATHWAY 9 67 5.778e-16 8.962e-13
4 EPITHELIUM DEVELOPMENT 17 945 3.597e-15 4.184e-12
5 POSITIVE REGULATION OF NOTCH SIGNALING PATHWAY 7 34 5.42e-14 5.044e-11
6 MORPHOGENESIS OF AN EPITHELIUM 12 400 3.483e-13 2.701e-10
7 TISSUE DEVELOPMENT 18 1518 5.036e-13 3.347e-10
8 EMBRYO DEVELOPMENT 15 894 7.784e-13 4.527e-10
9 ANATOMICAL STRUCTURE FORMATION INVOLVED IN MORPHOGENESIS 15 957 2.074e-12 1.072e-09
10 ORGAN MORPHOGENESIS 14 841 6.615e-12 3.078e-09
11 TISSUE MORPHOGENESIS 12 533 1.01e-11 4.274e-09
12 TUBE DEVELOPMENT 12 552 1.519e-11 5.889e-09
13 LYMPHOCYTE DIFFERENTIATION 9 209 2.066e-11 7.394e-09
14 REGULATION OF NERVOUS SYSTEM DEVELOPMENT 13 750 2.891e-11 8.968e-09
15 CELL SURFACE RECEPTOR SIGNALING PATHWAY INVOLVED IN HEART DEVELOPMENT 5 16 2.752e-11 8.968e-09
16 MORPHOGENESIS OF AN EPITHELIAL SHEET 6 43 4.857e-11 1.412e-08
17 HEART DEVELOPMENT 11 466 5.435e-11 1.488e-08
18 POSITIVE REGULATION OF GENE EXPRESSION 17 1733 6.621e-11 1.621e-08
19 B CELL DIFFERENTIATION 7 89 6.551e-11 1.621e-08
20 POSITIVE REGULATION OF CELL COMMUNICATION 16 1532 1.295e-10 3.013e-08
21 EMBRYONIC MORPHOGENESIS 11 539 2.558e-10 5.667e-08
22 POSITIVE REGULATION OF RESPONSE TO STIMULUS 17 1929 3.582e-10 7.576e-08
23 LEUKOCYTE DIFFERENTIATION 9 292 4.055e-10 8.203e-08
24 PATTERN SPECIFICATION PROCESS 10 418 4.282e-10 8.301e-08
25 EAR DEVELOPMENT 8 195 4.604e-10 8.498e-08
26 REGULATION OF MULTICELLULAR ORGANISMAL DEVELOPMENT 16 1672 4.749e-10 8.498e-08
27 IMMUNE SYSTEM DEVELOPMENT 11 582 5.759e-10 9.924e-08
28 HEART MORPHOGENESIS 8 212 8.935e-10 1.414e-07
29 CARDIOVASCULAR SYSTEM DEVELOPMENT 12 788 9.116e-10 1.414e-07
30 CIRCULATORY SYSTEM DEVELOPMENT 12 788 9.116e-10 1.414e-07
31 TUBE MORPHOGENESIS 9 323 9.865e-10 1.481e-07
32 B CELL ACTIVATION 7 132 1.071e-09 1.557e-07
33 POSITIVE REGULATION OF BIOSYNTHETIC PROCESS 16 1805 1.467e-09 2.069e-07
34 CELL FATE COMMITMENT 8 227 1.534e-09 2.099e-07
35 LYMPHOCYTE ACTIVATION 9 342 1.629e-09 2.166e-07
36 SENSORY ORGAN DEVELOPMENT 10 493 2.108e-09 2.725e-07
37 MATURE B CELL DIFFERENTIATION INVOLVED IN IMMUNE RESPONSE 4 13 3.343e-09 4.204e-07
38 SEGMENTATION 6 89 4.406e-09 5.396e-07
39 ENDOTHELIUM DEVELOPMENT 6 90 4.716e-09 5.627e-07
40 TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 11 724 5.667e-09 6.592e-07
41 EMBRYO DEVELOPMENT ENDING IN BIRTH OR EGG HATCHING 10 554 6.444e-09 7.139e-07
42 EPITHELIAL CELL FATE COMMITMENT 4 15 6.368e-09 7.139e-07
43 LEUKOCYTE ACTIVATION 9 414 8.619e-09 9.159e-07
44 REGULATION OF BINDING 8 283 8.661e-09 9.159e-07
45 CARDIAC CHAMBER MORPHOGENESIS 6 104 1.132e-08 1.145e-06
46 MATURE B CELL DIFFERENTIATION 4 17 1.108e-08 1.145e-06
47 REGULATION OF CELL DIFFERENTIATION 14 1492 1.232e-08 1.22e-06
48 POSITIVE REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 12 1004 1.396e-08 1.353e-06
49 REGULATION OF ANATOMICAL STRUCTURE MORPHOGENESIS 12 1021 1.683e-08 1.598e-06
50 REGIONALIZATION 8 311 1.806e-08 1.681e-06
51 REGULATION OF EMBRYONIC DEVELOPMENT 6 114 1.969e-08 1.796e-06
52 REGULATION OF CELL DEVELOPMENT 11 836 2.506e-08 2.242e-06
53 POSITIVE REGULATION OF BINDING 6 127 3.763e-08 3.304e-06
54 SOMITOGENESIS 5 62 3.878e-08 3.341e-06
55 EPITHELIAL CELL DIFFERENTIATION 9 495 4.025e-08 3.405e-06
56 NEUROGENESIS 13 1402 5.837e-08 4.765e-06
57 NEURON FATE COMMITMENT 5 67 5.756e-08 4.765e-06
58 SENSORY ORGAN MORPHOGENESIS 7 239 6.564e-08 5.266e-06
59 EPIDERMAL CELL DIFFERENTIATION 6 142 7.328e-08 5.78e-06
60 SKIN EPIDERMIS DEVELOPMENT 5 71 7.727e-08 5.992e-06
61 CARDIAC CHAMBER DEVELOPMENT 6 144 7.965e-08 6.075e-06
62 ENDOTHELIAL CELL DIFFERENTIATION 5 72 8.294e-08 6.225e-06
63 AUDITORY RECEPTOR CELL DIFFERENTIATION 4 28 9.419e-08 6.957e-06
64 EPIDERMIS DEVELOPMENT 7 253 9.682e-08 7.039e-06
65 REGULATION OF NEURON DIFFERENTIATION 9 554 1.053e-07 7.538e-06
66 TRANSCRIPTION INITIATION FROM RNA POLYMERASE II PROMOTER 6 153 1.142e-07 8.051e-06
67 REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 14 1784 1.184e-07 8.225e-06
68 SOMITE DEVELOPMENT 5 78 1.243e-07 8.446e-06
69 REGULATION OF CELL PROLIFERATION 13 1496 1.253e-07 8.446e-06
70 CELL ACTIVATION 9 568 1.302e-07 8.653e-06
71 REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER IN RESPONSE TO HYPOXIA 4 32 1.647e-07 1.079e-05
72 NEGATIVE REGULATION OF DEVELOPMENTAL PROCESS 10 801 2.071e-07 1.339e-05
73 HAIR CELL DIFFERENTIATION 4 35 2.391e-07 1.503e-05
74 B CELL ACTIVATION INVOLVED IN IMMUNE RESPONSE 4 35 2.391e-07 1.503e-05
75 RESPONSE TO OXYGEN LEVELS 7 311 3.923e-07 2.434e-05
76 ANTERIOR POSTERIOR PATTERN SPECIFICATION 6 194 4.638e-07 2.803e-05
77 NEURON DIFFERENTIATION 10 874 4.633e-07 2.803e-05
78 POSITIVE REGULATION OF MULTICELLULAR ORGANISMAL PROCESS 12 1395 5.132e-07 3.061e-05
79 CELL FATE DETERMINATION 4 43 5.586e-07 3.249e-05
80 VENTRICULAR TRABECULA MYOCARDIUM MORPHOGENESIS 3 11 5.517e-07 3.249e-05
81 DNA TEMPLATED TRANSCRIPTION INITIATION 6 202 5.879e-07 3.377e-05
82 REGULATION OF TIMING OF CELL DIFFERENTIATION 3 12 7.348e-07 4.07e-05
83 COLUMNAR CUBOIDAL EPITHELIAL CELL DIFFERENTIATION 5 111 7.283e-07 4.07e-05
84 REGULATION OF DEVELOPMENT HETEROCHRONIC 3 12 7.348e-07 4.07e-05
85 SKIN DEVELOPMENT 6 211 7.587e-07 4.153e-05
86 COVALENT CHROMATIN MODIFICATION 7 345 7.876e-07 4.261e-05
87 CARDIAC SEPTUM MORPHOGENESIS 4 49 9.528e-07 5.096e-05
88 ARTERY MORPHOGENESIS 4 51 1.121e-06 5.863e-05
89 MECHANORECEPTOR DIFFERENTIATION 4 51 1.121e-06 5.863e-05
90 REGULATION OF ESTABLISHMENT OF PLANAR POLARITY INVOLVED IN NEURAL TUBE CLOSURE 3 14 1.213e-06 6.203e-05
91 NEGATIVE REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 9 740 1.2e-06 6.203e-05
92 REGULATION OF CANONICAL WNT SIGNALING PATHWAY 6 236 1.457e-06 7.369e-05
93 N TERMINAL PROTEIN AMINO ACID ACETYLATION 3 15 1.515e-06 7.58e-05
94 TUBE FORMATION 5 129 1.534e-06 7.592e-05
95 OUTFLOW TRACT MORPHOGENESIS 4 56 1.639e-06 8.029e-05
96 REGULATION OF ORGAN MORPHOGENESIS 6 242 1.686e-06 8.17e-05
97 MAINTENANCE OF CELL NUMBER 5 132 1.718e-06 8.241e-05
98 MORPHOGENESIS OF EMBRYONIC EPITHELIUM 5 134 1.85e-06 8.754e-05
99 MORPHOGENESIS OF AN ENDOTHELIUM 3 16 1.863e-06 8.754e-05
100 MEMBRANE PROTEIN INTRACELLULAR DOMAIN PROTEOLYSIS 3 17 2.259e-06 0.0001051
101 EMBRYONIC DIGIT MORPHOGENESIS 4 61 2.317e-06 0.0001067
102 CARDIAC VENTRICLE MORPHOGENESIS 4 62 2.474e-06 0.0001128
103 NEUROEPITHELIAL CELL DIFFERENTIATION 4 63 2.639e-06 0.0001192
104 REGULATION OF PROTEIN ACETYLATION 4 64 2.811e-06 0.0001258
105 POSITIVE REGULATION OF CELL DIFFERENTIATION 9 823 2.885e-06 0.0001279
106 NEGATIVE REGULATION OF CELL DIFFERENTIATION 8 609 2.997e-06 0.0001315
107 NEURAL TUBE DEVELOPMENT 5 149 3.118e-06 0.0001356
108 IMMUNE SYSTEM PROCESS 13 1984 3.208e-06 0.0001371
109 NEURONAL STEM CELL POPULATION MAINTENANCE 3 19 3.213e-06 0.0001371
110 REGULATION OF DNA TEMPLATED TRANSCRIPTION IN RESPONSE TO STRESS 4 67 3.381e-06 0.000143
111 REGULATION OF MUSCLE CELL DIFFERENTIATION 5 152 3.439e-06 0.0001441
112 MUSCLE TISSUE DEVELOPMENT 6 275 3.529e-06 0.0001453
113 MUSCLE STRUCTURE DEVELOPMENT 7 432 3.509e-06 0.0001453
114 POSITIVE REGULATION OF NERVOUS SYSTEM DEVELOPMENT 7 437 3.785e-06 0.0001545
115 COCHLEA MORPHOGENESIS 3 21 4.4e-06 0.000178
116 NEGATIVE REGULATION OF CANONICAL WNT SIGNALING PATHWAY 5 162 4.697e-06 0.0001884
117 BETA CATENIN DESTRUCTION COMPLEX DISASSEMBLY 3 22 5.09e-06 0.0001957
118 MEMBRANE PROTEIN ECTODOMAIN PROTEOLYSIS 3 22 5.09e-06 0.0001957
119 SOMATIC STEM CELL DIVISION 3 22 5.09e-06 0.0001957
120 ANGIOGENESIS 6 293 5.081e-06 0.0001957
121 AORTA MORPHOGENESIS 3 22 5.09e-06 0.0001957
122 POSITIVE REGULATION OF DEVELOPMENTAL PROCESS 10 1142 5.214e-06 0.0001973
123 CELL DEVELOPMENT 11 1426 5.201e-06 0.0001973
124 ARTERY DEVELOPMENT 4 75 5.315e-06 0.0001994
125 RHYTHMIC PROCESS 6 298 5.599e-06 0.0002084
126 POSITIVE REGULATION OF CELL DEVELOPMENT 7 472 6.277e-06 0.0002318
127 REGULATION OF WNT SIGNALING PATHWAY 6 310 7.018e-06 0.0002571
128 HAIR CYCLE 4 83 7.966e-06 0.0002873
129 MOLTING CYCLE 4 83 7.966e-06 0.0002873
130 HEART TRABECULA MORPHOGENESIS 3 26 8.557e-06 0.0003039
131 N TERMINAL PROTEIN AMINO ACID MODIFICATION 3 26 8.557e-06 0.0003039
132 CARDIAC SEPTUM DEVELOPMENT 4 85 8.758e-06 0.0003064
133 REGULATION OF STRIATED MUSCLE CELL DIFFERENTIATION 4 85 8.758e-06 0.0003064
134 TISSUE REMODELING 4 87 9.607e-06 0.0003315
135 POSITIVE REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER INVOLVED IN CELLULAR RESPONSE TO CHEMICAL STIMULUS 3 27 9.617e-06 0.0003315
136 NEGATIVE REGULATION OF NEURON DIFFERENTIATION 5 191 1.047e-05 0.0003581
137 NEGATIVE REGULATION OF NOTCH SIGNALING PATHWAY 3 28 1.076e-05 0.0003616
138 CELL MORPHOGENESIS INVOLVED IN DIFFERENTIATION 7 513 1.08e-05 0.0003616
139 REGULATION OF SPROUTING ANGIOGENESIS 3 28 1.076e-05 0.0003616
140 STEM CELL DIVISION 3 29 1.199e-05 0.0003984
141 NEGATIVE REGULATION OF WNT SIGNALING PATHWAY 5 197 1.216e-05 0.0004013
142 NEURAL TUBE FORMATION 4 94 1.306e-05 0.000428
143 CARDIOCYTE DIFFERENTIATION 4 96 1.42e-05 0.000462
144 CARDIAC ATRIUM DEVELOPMENT 3 31 1.472e-05 0.0004755
145 CHROMATIN MODIFICATION 7 539 1.488e-05 0.0004776
146 LYMPHOCYTE ACTIVATION INVOLVED IN IMMUNE RESPONSE 4 98 1.541e-05 0.000491
147 ENDOCARDIAL CUSHION DEVELOPMENT 3 32 1.622e-05 0.00051
148 BLOOD VESSEL REMODELING 3 32 1.622e-05 0.00051
149 BLOOD VESSEL MORPHOGENESIS 6 364 1.748e-05 0.0005458
150 HEART VALVE DEVELOPMENT 3 34 1.953e-05 0.0006058
151 CARDIAC VENTRICLE DEVELOPMENT 4 106 2.101e-05 0.0006473
152 MEMBRANE PROTEIN PROTEOLYSIS 3 35 2.134e-05 0.0006532
153 POSITIVE REGULATION OF PROTEIN ACETYLATION 3 36 2.325e-05 0.0007072
154 NEGATIVE REGULATION OF RESPONSE TO STIMULUS 10 1360 2.42e-05 0.0007313
155 MYOBLAST DIFFERENTIATION 3 37 2.528e-05 0.000754
156 NEGATIVE REGULATION OF EPITHELIAL CELL DIFFERENTIATION 3 37 2.528e-05 0.000754
157 TRABECULA MORPHOGENESIS 3 39 2.967e-05 0.0008738
158 COCHLEA DEVELOPMENT 3 39 2.967e-05 0.0008738
159 POSITIVE REGULATION OF GROWTH 5 238 3.02e-05 0.0008837
160 EMBRYONIC ORGAN DEVELOPMENT 6 406 3.23e-05 0.0009393
161 AORTA DEVELOPMENT 3 41 3.454e-05 0.0009981
162 REGULATION OF EPITHELIAL CELL DIFFERENTIATION 4 122 3.65e-05 0.001048
163 T CELL DIFFERENTIATION 4 123 3.769e-05 0.001076
164 BETA CATENIN TCF COMPLEX ASSEMBLY 3 43 3.99e-05 0.001132
165 POSITIVE REGULATION OF MOLECULAR FUNCTION 11 1791 4.5e-05 0.001269
166 PROTEIN ACETYLATION 4 129 4.541e-05 0.001273
167 VENTRICULAR CARDIAC MUSCLE TISSUE DEVELOPMENT 3 45 4.578e-05 0.001276
168 NEGATIVE REGULATION OF CELL PROLIFERATION 7 643 4.609e-05 0.001277
169 NEGATIVE REGULATION OF NERVOUS SYSTEM DEVELOPMENT 5 262 4.775e-05 0.001309
170 REGULATION OF CELL DEATH 10 1472 4.783e-05 0.001309
171 HISTONE H3 ACETYLATION 3 46 4.892e-05 0.001331
172 CHROMATIN ORGANIZATION 7 663 5.596e-05 0.001511
173 NEGATIVE REGULATION OF CELL COMMUNICATION 9 1192 5.618e-05 0.001511
174 CELL ACTIVATION INVOLVED IN IMMUNE RESPONSE 4 139 6.076e-05 0.001625
175 MUSCLE ORGAN DEVELOPMENT 5 277 6.218e-05 0.001652
176 CARDIAC MUSCLE TISSUE DEVELOPMENT 4 140 6.248e-05 0.001652
177 EMBRYONIC ORGAN MORPHOGENESIS 5 279 6.434e-05 0.001691
178 CELLULAR RESPONSE TO OXYGEN LEVELS 4 143 6.786e-05 0.001774
179 VASCULATURE DEVELOPMENT 6 469 7.205e-05 0.001873
180 CARDIAC MUSCLE TISSUE MORPHOGENESIS 3 54 7.927e-05 0.002049
181 CHROMATIN REMODELING 4 150 8.169e-05 0.0021
182 NEGATIVE REGULATION OF MUSCLE CELL DIFFERENTIATION 3 55 8.376e-05 0.002141
183 IMMUNE EFFECTOR PROCESS 6 486 8.768e-05 0.002229
184 POSITIVE REGULATION OF MUSCLE TISSUE DEVELOPMENT 3 56 8.841e-05 0.002236
185 NEGATIVE REGULATION OF CELL DEVELOPMENT 5 303 9.496e-05 0.002354
186 POSITIVE REGULATION OF DEVELOPMENTAL GROWTH 4 156 9.51e-05 0.002354
187 NEGATIVE REGULATION OF MULTICELLULAR ORGANISMAL PROCESS 8 983 9.494e-05 0.002354
188 POSITIVE REGULATION OF CELL PROJECTION ORGANIZATION 5 303 9.496e-05 0.002354
189 PROTEIN ACYLATION 4 159 0.0001024 0.00252
190 POSITIVE REGULATION OF CELL MORPHOGENESIS INVOLVED IN DIFFERENTIATION 4 162 0.00011 0.002695
191 REGULATION OF VIRAL TRANSCRIPTION 3 61 0.0001142 0.002782
192 REGULATION OF PROTEIN BINDING 4 168 0.0001266 0.002979
193 LOOP OF HENLE DEVELOPMENT 2 11 0.0001268 0.002979
194 ENDOCARDIUM DEVELOPMENT 2 11 0.0001268 0.002979
195 NEGATIVE REGULATION OF SPROUTING ANGIOGENESIS 2 11 0.0001268 0.002979
196 POSITIVE REGULATION OF RECEPTOR BIOSYNTHETIC PROCESS 2 11 0.0001268 0.002979
197 EPITHELIAL TO MESENCHYMAL TRANSITION INVOLVED IN ENDOCARDIAL CUSHION FORMATION 2 11 0.0001268 0.002979
198 ENDOTHELIAL TUBE MORPHOGENESIS 2 11 0.0001268 0.002979
199 APPENDAGE DEVELOPMENT 4 169 0.0001295 0.003014
200 LIMB DEVELOPMENT 4 169 0.0001295 0.003014
201 DEVELOPMENTAL GROWTH 5 333 0.0001478 0.003422
202 CARDIAC LEFT VENTRICLE MORPHOGENESIS 2 12 0.000152 0.00345
203 AMYLOID PRECURSOR PROTEIN METABOLIC PROCESS 2 12 0.000152 0.00345
204 DISTAL TUBULE DEVELOPMENT 2 12 0.000152 0.00345
205 LATERAL VENTRICLE DEVELOPMENT 2 12 0.000152 0.00345
206 MUSCLE ORGAN MORPHOGENESIS 3 70 0.000172 0.003886
207 NEURONAL STEM CELL DIVISION 2 13 0.0001794 0.003902
208 EYELID DEVELOPMENT IN CAMERA TYPE EYE 2 13 0.0001794 0.003902
209 LEFT RIGHT AXIS SPECIFICATION 2 13 0.0001794 0.003902
210 CARDIOBLAST DIFFERENTIATION 2 13 0.0001794 0.003902
211 NEGATIVE REGULATION OF EPIDERMAL CELL DIFFERENTIATION 2 13 0.0001794 0.003902
212 NEUROBLAST DIVISION 2 13 0.0001794 0.003902
213 CELL FATE SPECIFICATION 3 71 0.0001794 0.003902
214 POSITIVE REGULATION OF GLUCONEOGENESIS 2 13 0.0001794 0.003902
215 EPITHELIAL CELL DEVELOPMENT 4 186 0.0001872 0.004033
216 REGULATION OF CELL PROJECTION ORGANIZATION 6 558 0.0001865 0.004033
217 POSITIVE REGULATION OF PROTEIN BINDING 3 73 0.0001949 0.004178
218 REGULATION OF CYTOKINE PRODUCTION 6 563 0.0001958 0.004179
219 POSITIVE REGULATION OF CELL PROLIFERATION 7 814 0.0002014 0.004278
220 FOREBRAIN DEVELOPMENT 5 357 0.0002043 0.004322
221 IMMUNE RESPONSE 8 1100 0.0002069 0.004357
222 CONVERGENT EXTENSION 2 14 0.0002091 0.004384
223 ODONTOGENESIS OF DENTIN CONTAINING TOOTH 3 75 0.0002111 0.004405
224 POSITIVE REGULATION OF GENE EXPRESSION EPIGENETIC 3 78 0.0002371 0.004835
225 RESPONSE TO MURAMYL DIPEPTIDE 2 15 0.0002411 0.004835
226 ENDOCARDIAL CUSHION FORMATION 2 15 0.0002411 0.004835
227 RENAL TUBULE DEVELOPMENT 3 78 0.0002371 0.004835
228 ECTODERMAL PLACODE DEVELOPMENT 2 15 0.0002411 0.004835
229 REGULATION OF CELL PROLIFERATION INVOLVED IN HEART MORPHOGENESIS 2 15 0.0002411 0.004835
230 RESPIRATORY SYSTEM DEVELOPMENT 4 197 0.0002333 0.004835
231 ECTODERMAL PLACODE MORPHOGENESIS 2 15 0.0002411 0.004835
232 ECTODERMAL PLACODE FORMATION 2 15 0.0002411 0.004835
233 POSITIVE REGULATION OF PROTEIN MODIFICATION PROCESS 8 1135 0.0002564 0.00512
234 CARDIAC RIGHT VENTRICLE MORPHOGENESIS 2 16 0.0002753 0.005427
235 NEGATIVE REGULATION OF EPIDERMIS DEVELOPMENT 2 16 0.0002753 0.005427
236 APOPTOTIC PROCESS INVOLVED IN MORPHOGENESIS 2 16 0.0002753 0.005427
237 POSITIVE REGULATION OF CELLULAR COMPONENT ORGANIZATION 8 1152 0.0002837 0.00557
238 POSITIVE REGULATION OF CHROMATIN MODIFICATION 3 85 0.0003056 0.005949
239 NEGATIVE REGULATION OF CELL DEATH 7 872 0.0003068 0.005949
240 CENTRAL NERVOUS SYSTEM DEVELOPMENT 7 872 0.0003068 0.005949
241 REGULATION OF CHROMATIN BINDING 2 17 0.0003117 0.005979
242 POSITIVE REGULATION OF PROTEIN METABOLIC PROCESS 9 1492 0.0003122 0.005979
243 SEGMENT SPECIFICATION 2 17 0.0003117 0.005979
244 NEGATIVE REGULATION OF GENE EXPRESSION 9 1493 0.0003138 0.005984
245 NEGATIVE REGULATION OF MYOTUBE DIFFERENTIATION 2 18 0.0003503 0.006625
246 PERICARDIUM DEVELOPMENT 2 18 0.0003503 0.006625
247 NEGATIVE REGULATION OF NITROGEN COMPOUND METABOLIC PROCESS 9 1517 0.0003534 0.006658
248 REGULATION OF PROTEIN STABILITY 4 221 0.0003612 0.006777
249 CELLULAR COMPONENT MORPHOGENESIS 7 900 0.0003717 0.006947
250 REGULATION OF NEURON PROJECTION DEVELOPMENT 5 408 0.0003782 0.00704
251 GROWTH 5 410 0.0003868 0.007142
252 INNER EAR MORPHOGENESIS 3 92 0.0003857 0.007142
253 REGULATION OF CELL MIGRATION INVOLVED IN SPROUTING ANGIOGENESIS 2 19 0.0003911 0.007165
254 POSITIVE REGULATION OF CARDIAC MUSCLE CELL PROLIFERATION 2 19 0.0003911 0.007165
255 NEPHRON EPITHELIUM DEVELOPMENT 3 93 0.0003981 0.007236
256 REGULATION OF DNA BINDING 3 93 0.0003981 0.007236
257 REGULATION OF CELLULAR RESPONSE TO GROWTH FACTOR STIMULUS 4 229 0.0004132 0.007452
258 REGULATION OF GENE EXPRESSION EPIGENETIC 4 229 0.0004132 0.007452
259 CANONICAL WNT SIGNALING PATHWAY 3 95 0.0004238 0.007613
260 TONGUE DEVELOPMENT 2 20 0.0004342 0.00774
261 POSITIVE REGULATION OF NEURON PROJECTION DEVELOPMENT 4 232 0.000434 0.00774
262 INTERSPECIES INTERACTION BETWEEN ORGANISMS 6 662 0.0004666 0.008255
263 SYMBIOSIS ENCOMPASSING MUTUALISM THROUGH PARASITISM 6 662 0.0004666 0.008255
264 MUSCLE CELL DIFFERENTIATION 4 237 0.0004704 0.008291
265 LEFT RIGHT PATTERN FORMATION 2 21 0.0004794 0.008354
266 REGULATION OF RECEPTOR BIOSYNTHETIC PROCESS 2 21 0.0004794 0.008354
267 APOPTOTIC PROCESS INVOLVED IN DEVELOPMENT 2 21 0.0004794 0.008354
268 POSITIVE REGULATION OF TRANSMEMBRANE RECEPTOR PROTEIN SERINE THREONINE KINASE SIGNALING PATHWAY 3 100 0.0004925 0.00855
269 KERATINOCYTE DIFFERENTIATION 3 101 0.000507 0.008737
270 CELL PROLIFERATION 6 672 0.0005052 0.008737
271 ENDOCARDIAL CUSHION MORPHOGENESIS 2 22 0.0005268 0.008946
272 REGULATION OF ANDROGEN RECEPTOR SIGNALING PATHWAY 2 22 0.0005268 0.008946
273 MODULATION OF TRANSCRIPTION IN OTHER ORGANISM INVOLVED IN SYMBIOTIC INTERACTION 2 22 0.0005268 0.008946
274 HISTONE H3 DEACETYLATION 2 22 0.0005268 0.008946
275 REGULATION OF MUSCLE TISSUE DEVELOPMENT 3 103 0.0005369 0.009052
276 REGULATION OF MUSCLE ORGAN DEVELOPMENT 3 103 0.0005369 0.009052
277 ODONTOGENESIS 3 105 0.0005679 0.00954
278 POSITIVE REGULATION OF MULTICELLULAR ORGANISMAL METABOLIC PROCESS 2 23 0.0005764 0.009579
279 POSITIVE REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER IN RESPONSE TO STRESS 2 23 0.0005764 0.009579
280 POSITIVE REGULATION OF COLLAGEN METABOLIC PROCESS 2 23 0.0005764 0.009579
281 SPINAL CORD DEVELOPMENT 3 106 0.0005839 0.009668
NumGOOverlapSizeP ValueAdj. P Value
1 NOTCH BINDING 8 18 5.389e-19 5.006e-16
2 TRANSCRIPTION FACTOR BINDING 10 524 3.784e-09 1.758e-06
3 TRANSCRIPTION FACTOR ACTIVITY PROTEIN BINDING 10 588 1.136e-08 2.458e-06
4 CHROMATIN BINDING 9 435 1.323e-08 2.458e-06
5 RECEPTOR BINDING 14 1476 1.073e-08 2.458e-06
6 RNA POLYMERASE II TRANSCRIPTION FACTOR BINDING 5 104 5.265e-07 8.153e-05
7 CORE PROMOTER BINDING 5 152 3.439e-06 0.0003993
8 PEPTIDE N ACETYLTRANSFERASE ACTIVITY 4 67 3.381e-06 0.0003993
9 TRANSCRIPTION COACTIVATOR ACTIVITY 6 296 5.387e-06 0.000556
10 CHROMATIN DNA BINDING 4 80 6.878e-06 0.000639
11 BETA CATENIN BINDING 4 84 8.355e-06 0.0006872
12 RNA POLYMERASE II REPRESSING TRANSCRIPTION FACTOR BINDING 3 27 9.617e-06 0.0006872
13 N ACETYLTRANSFERASE ACTIVITY 4 87 9.607e-06 0.0006872
14 NF KAPPAB BINDING 3 30 1.331e-05 0.000883
15 HISTONE DEACETYLASE BINDING 4 105 2.023e-05 0.001106
16 ACETYLTRANSFERASE ACTIVITY 4 103 1.876e-05 0.001106
17 N ACYLTRANSFERASE ACTIVITY 4 104 1.949e-05 0.001106
18 FRIZZLED BINDING 3 36 2.325e-05 0.0012
19 RAC GTPASE BINDING 3 39 2.967e-05 0.001417
20 MACROMOLECULAR COMPLEX BINDING 10 1399 3.091e-05 0.001417
21 STRUCTURE SPECIFIC DNA BINDING 4 118 3.203e-05 0.001417
22 ENZYME BINDING 11 1737 3.386e-05 0.00143
23 TRANSCRIPTION FACTOR ACTIVITY RNA POLYMERASE II TRANSCRIPTION FACTOR BINDING 4 133 5.116e-05 0.002066
24 CALCIUM ION BINDING 7 697 7.67e-05 0.002969
25 ACTIVATING TRANSCRIPTION FACTOR BINDING 3 57 9.322e-05 0.003331
26 REPRESSING TRANSCRIPTION FACTOR BINDING 3 57 9.322e-05 0.003331
27 HISTONE DEACETYLASE ACTIVITY H3 K14 SPECIFIC 2 12 0.000152 0.005229
28 REGULATORY REGION NUCLEIC ACID BINDING 7 818 0.0002075 0.006885
29 RHO GTPASE BINDING 3 78 0.0002371 0.007318
30 PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR BINDING 2 15 0.0002411 0.007318
31 CORE PROMOTER PROXIMAL REGION DNA BINDING 5 371 0.0002442 0.007318
32 ZINC ION BINDING 8 1155 0.0002888 0.008384
33 TRANSFERASE ACTIVITY TRANSFERRING ACYL GROUPS OTHER THAN AMINO ACYL GROUPS 4 211 0.000303 0.008395
34 TRANSCRIPTIONAL REPRESSOR ACTIVITY RNA POLYMERASE II TRANSCRIPTION FACTOR BINDING 3 86 0.0003163 0.008395
35 NAD DEPENDENT PROTEIN DEACETYLASE ACTIVITY 2 17 0.0003117 0.008395
36 LIGASE ACTIVITY 5 406 0.0003698 0.009543
NumGOOverlapSizeP ValueAdj. P Value
1 CHROMATIN 8 441 2.651e-07 7.741e-05
2 NUCLEAR CHROMATIN 7 291 2.504e-07 7.741e-05
3 APICAL PART OF CELL 7 361 1.066e-06 0.0002076
4 CHROMOSOME 9 880 4.988e-06 0.0005883
5 TRANSCRIPTIONAL REPRESSOR COMPLEX 4 74 5.037e-06 0.0005883
6 NUCLEAR CHROMOSOME 7 523 1.225e-05 0.001192
7 ACETYLTRANSFERASE COMPLEX 4 100 1.669e-05 0.001392
8 NUCLEOPLASM PART 7 708 8.462e-05 0.004942
9 GOLGI MEMBRANE 7 703 8.094e-05 0.004942
10 APICAL PLASMA MEMBRANE 5 292 7.978e-05 0.004942
11 HISTONE DEACETYLASE COMPLEX 3 61 0.0001142 0.006062
12 WNT SIGNALOSOME 2 11 0.0001268 0.00617
13 SIN3 COMPLEX 2 13 0.0001794 0.008061

Over-represented Pathway

NumPathwayPathviewOverlapSizeP ValueAdj. P Value
1 hsa04330_Notch_signaling_pathway 31 47 5.891e-88 1.06e-85
2 hsa04310_Wnt_signaling_pathway 6 151 1.056e-07 9.506e-06
3 hsa04916_Melanogenesis 5 101 4.55e-07 2.73e-05
4 hsa04320_Dorso.ventral_axis_formation 3 25 7.578e-06 0.000341
5 hsa04110_Cell_cycle 4 128 4.405e-05 0.001586
6 hsa04390_Hippo_signaling_pathway 3 154 0.001718 0.05154
7 hsa00514_Other_types_of_O.glycan_biosynthesis 2 46 0.002306 0.05931
8 hsa04720_Long.term_potentiation 2 70 0.005259 0.1141
9 hsa04520_Adherens_junction 2 73 0.005706 0.1141
10 hsa04350_TGF.beta_signaling_pathway 2 85 0.007662 0.1379
11 hsa04630_Jak.STAT_signaling_pathway 2 155 0.02396 0.392

lncRNA-mediated sponge

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Num lncRNA miRNAs           miRNAs count     Gene Sponge regulatory network lncRNA log2FC lncRNA pvalue Gene log2FC Gene pvalue lncRNA-gene Pearson correlation
1 TPRG1-AS1 hsa-miR-106a-5p;hsa-miR-106b-5p;hsa-miR-125a-3p;hsa-miR-17-5p;hsa-miR-181a-5p;hsa-miR-181b-5p;hsa-miR-181c-5p;hsa-miR-181d-5p;hsa-miR-19a-3p;hsa-miR-19b-3p;hsa-miR-20a-5p;hsa-miR-92a-3p;hsa-miR-92b-3p;hsa-miR-93-5p 14 KAT2B Sponge network -0.756 0.03021 -0.939 0 0.573
2 RP11-12A2.3 hsa-miR-106b-5p;hsa-miR-17-5p;hsa-miR-181a-5p;hsa-miR-181b-5p;hsa-miR-181c-5p;hsa-miR-181d-5p;hsa-miR-19a-3p;hsa-miR-19b-3p;hsa-miR-20a-5p;hsa-miR-25-3p;hsa-miR-92a-3p;hsa-miR-92b-3p;hsa-miR-93-5p 13 KAT2B Sponge network -4.779 0 -0.939 0 0.539
3 AC004862.6 hsa-miR-106b-5p;hsa-miR-125a-3p;hsa-miR-17-5p;hsa-miR-181a-5p;hsa-miR-181b-5p;hsa-miR-181c-5p;hsa-miR-181d-5p;hsa-miR-19a-3p;hsa-miR-20a-5p;hsa-miR-20b-5p;hsa-miR-93-5p 11 KAT2B Sponge network -2.202 0.00081 -0.939 0 0.489
4 LINC00238 hsa-miR-106a-5p;hsa-miR-106b-5p;hsa-miR-125a-3p;hsa-miR-17-5p;hsa-miR-181a-5p;hsa-miR-181b-5p;hsa-miR-181c-5p;hsa-miR-181d-5p;hsa-miR-19a-3p;hsa-miR-19b-3p;hsa-miR-20a-5p;hsa-miR-20b-5p;hsa-miR-342-3p 13 KAT2B Sponge network -4.997 0 -0.939 0 0.478
5 AC005550.3 hsa-miR-17-5p;hsa-miR-181a-5p;hsa-miR-181b-5p;hsa-miR-181c-5p;hsa-miR-181d-5p;hsa-miR-19a-3p;hsa-miR-19b-3p;hsa-miR-20a-3p;hsa-miR-20a-5p;hsa-miR-92a-3p;hsa-miR-92b-3p 11 KAT2B Sponge network -2.571 0.00132 -0.939 0 0.44
6 RP11-166D19.1 hsa-miR-106a-5p;hsa-miR-106b-5p;hsa-miR-17-5p;hsa-miR-19a-3p;hsa-miR-19b-3p;hsa-miR-20a-3p;hsa-miR-20a-5p;hsa-miR-25-3p;hsa-miR-590-5p;hsa-miR-92a-3p 10 KAT2B Sponge network -0.244 0.28835 -0.939 0 0.254

Quest ID: 26f441f5cb43ee581815612a42fe72fe