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This regulatory network was inferred from the input dataset. The miRNAs and mRNAs are presented as round and rectangle nodes respectively. The numerical value popped up upon mouse over the gene node is the log2 transformed fold-change of the gene expression between the two groups. All of the nodes are clickable, and the detailed information of the miRNAs/mRNAs and related cancer pathway will be displayed in another window. The edges between nodes are supported by both interactions (predicted or experimentally verified) and correlations learnt from cancer dataset. The numerical value popped up upon mouse over the edge is the correlation beat value (effect size) between the two nodes. The experimental evidences of the edges reported in previous cancer studies are highlighted by red/orange color. All of these information can be accessed by the "mouse-over" action. This network shows a full map of the miRNA-mRNA regulation of the input gene list(s), and the hub miRNAs (with the high network degree/betweenness centrality) would be the potential cancer drivers or tumor suppressors. The full result table can be accessed in the "Regulations" tab.

"miRNACancerMAP" is also a network visualization tool for users to draw their regulatory network by personal customization. Users can set the complexity of the network by limiting the number of nodes or edges. And the color of the nodes can be defined by different categories of the mRNAs and miRNAs, such as Gene-Ontology, pathway, and expression status. Users can also select to use network degree or network betweenness centrality to define the node size. And edges can be black or colored by the correlation. Purple edge means negative correlation (mostly found between miRNA and mRNA), and blue edge means positive correlation (found in PPI or miRNA-miRNA sponge effect). We can also add the protein-protein interactions (PPI) into the network. This result will show the cluster of genes regulated by some specific miRNAs. Additionally, miRNA-miRNA edges can be added by the "miRNA sponge" button, presenting some clusters of miRNAs that have the interactions via sponge effect.

miRNA-gene regulations

(Download full result)

Num microRNA           Gene miRNA log2FC miRNA pvalue Gene log2FC Gene pvalue Interaction Correlation beta Correlation P-value PMID Reported in cancer studies
1 hsa-miR-106a-5p BMP2 -0.2 0.80221 -0.46 0.61561 miRNATAP -0.33 0.00015 NA
2 hsa-miR-17-5p BMP2 -0.18 0.93454 -0.46 0.61561 TargetScan -0.34 1.0E-5 NA
3 hsa-miR-20a-5p BMP2 -0.18 0.92812 -0.46 0.61561 miRNATAP -0.3 9.0E-5 NA
4 hsa-miR-335-3p BMP2 -0.24 0.8845 -0.46 0.61561 mirMAP -0.37 0 NA
5 hsa-miR-335-5p BMP2 -0.03 0.97338 -0.46 0.61561 miRNAWalker2 validate -0.34 3.0E-5 NA
6 hsa-miR-140-5p CTNNB1 -0.23 0.84733 -0.27 0.89738 miRanda -0.14 0.00185 NA
7 hsa-miR-126-5p EPB41L5 0.08 0.95664 0.08 0.93187 mirMAP -0.13 0.00811 NA
8 hsa-miR-134-5p EPB41L5 0.04 0.98112 0.08 0.93187 MirTarget -0.14 0.00684 NA
9 hsa-miR-15b-5p EPB41L5 -0.27 0.87097 0.08 0.93187 MirTarget -0.12 0.0047 NA
10 hsa-miR-34c-3p EPB41L5 -0.07 0.82545 0.08 0.93187 mirMAP -0.14 2.0E-5 NA
11 hsa-miR-485-3p EPB41L5 -0.08 0.84013 0.08 0.93187 mirMAP -0.11 0.00084 NA
12 hsa-miR-429 FAM83D -0.46 0.80624 -0.17 0.88786 miRanda -0.11 0.00438 NA
13 hsa-miR-188-5p FGFR2 -0.57 0.32482 -0.38 0.68877 PITA -0.41 0 NA
14 hsa-miR-19b-1-5p FGFR2 -0.01 0.98851 -0.38 0.68877 miRNAWalker2 validate; miRTarBase -0.47 2.0E-5 NA
15 hsa-miR-369-3p FGFR2 0.12 0.8323 -0.38 0.68877 miRNATAP -0.33 0.00975 NA
16 hsa-miR-542-3p FGFR2 0.19 0.90925 -0.38 0.68877 miRanda -0.72 0 NA
17 hsa-miR-940 FGFR2 -0.23 0.68006 -0.38 0.68877 miRNATAP -0.27 0.00208 NA
18 hsa-miR-130b-3p FOXF2 -0.22 0.82466 0.3 0.59948 miRNATAP -0.56 0 NA
19 hsa-miR-142-3p FOXF2 -0.15 0.9461 0.3 0.59948 miRanda -0.34 1.0E-5 NA
20 hsa-miR-182-5p FOXF2 -0.1 0.97338 0.3 0.59948 miRNAWalker2 validate; miRNATAP -0.23 0.00659 25738520 miR 182 promotes cell growth and invasion by targeting forkhead box F2 transcription factor in colorectal cancer; In the present study we aimed to investigate the role of miR-182 in colorectal cancer CRC and identify the regulation of FoxF2 by miR-182; The direct binding of miR-182 to the 3' untranslated region 3'UTR of FoxF2 mRNA was confirmed using a luciferase reporter gene assay
21 hsa-miR-19a-3p FOXF2 -0.21 0.84464 0.3 0.59948 miRNATAP -0.47 0 NA
22 hsa-miR-19b-3p FOXF2 -0.03 0.98666 0.3 0.59948 miRNATAP -0.48 0 NA
23 hsa-miR-200b-3p FOXF2 -0.43 0.86396 0.3 0.59948 TargetScan -0.37 9.0E-5 25798833 The miR 200 family and the miR 183~96~182 cluster target Foxf2 to inhibit invasion and metastasis in lung cancers; We therefore identified a novel mechanism whereby the miR-200 family and the miR-183~96~182 cluster inhibit lung cancer invasion and metastasis by targeting Foxf2
24 hsa-miR-200c-3p FOXF2 -0.44 0.88712 0.3 0.59948 miRNATAP -0.48 0 NA
25 hsa-miR-26b-5p FOXF2 -0.02 0.99038 0.3 0.59948 miRNAWalker2 validate -0.67 0 NA
26 hsa-miR-301a-3p FOXF2 -0.11 0.83169 0.3 0.59948 miRNATAP -0.34 4.0E-5 NA
27 hsa-miR-429 FOXF2 -0.46 0.80624 0.3 0.59948 PITA; miRanda; miRNATAP -0.34 1.0E-5 NA
28 hsa-miR-454-3p FOXF2 -0.1 0.84355 0.3 0.59948 miRNATAP -0.41 0.00029 NA
29 hsa-miR-590-3p FOXF2 -0.28 0.59127 0.3 0.59948 PITA; miRanda -0.51 0 NA
30 hsa-miR-96-5p FOXF2 0.09 0.92309 0.3 0.59948 TargetScan; miRNATAP -0.38 0 NA
31 hsa-miR-132-3p GSK3B -0.24 0.87175 -0.03 0.98417 mirMAP; miRNATAP -0.11 0.00091 NA
32 hsa-miR-146b-3p GSK3B -0.41 0.76252 -0.03 0.98417 miRNATAP -0.12 0 NA
33 hsa-miR-146b-5p GSK3B -0.4 0.83751 -0.03 0.98417 miRanda -0.14 0 NA
34 hsa-miR-155-5p GSK3B -0.41 0.82867 -0.03 0.98417 miRNAWalker2 validate; miRNATAP -0.1 0 NA
35 hsa-miR-212-3p GSK3B -0.02 0.97323 -0.03 0.98417 mirMAP; miRNATAP -0.11 2.0E-5 NA
36 hsa-let-7a-3p HGF -0.22 0.85543 -0.22 0.64343 mirMAP -0.88 0 NA
37 hsa-let-7f-1-3p HGF -0.31 0.69341 -0.22 0.64343 mirMAP -0.83 1.0E-5 NA
38 hsa-miR-126-5p HGF 0.08 0.95664 -0.22 0.64343 mirMAP -0.52 0.00097 NA
39 hsa-miR-140-5p HGF -0.23 0.84733 -0.22 0.64343 miRanda -0.65 0.00025 NA
40 hsa-miR-141-3p HGF -0.32 0.87774 -0.22 0.64343 MirTarget; TargetScan -0.73 0 NA
41 hsa-miR-200a-3p HGF -0.37 0.85106 -0.22 0.64343 MirTarget -0.6 0 NA
42 hsa-miR-203a-3p HGF -0.27 0.93159 -0.22 0.64343 MirTarget -0.46 0 NA
43 hsa-miR-26b-5p HGF -0.02 0.99038 -0.22 0.64343 MirTarget; miRNATAP -1.17 0 NA
44 hsa-miR-29a-5p HGF -0.32 0.60044 -0.22 0.64343 mirMAP -0.71 0 NA
45 hsa-miR-30b-5p HGF -0.01 0.99462 -0.22 0.64343 mirMAP -0.73 0 NA
46 hsa-miR-30c-5p HGF -0.3 0.86581 -0.22 0.64343 mirMAP -0.9 0 NA
47 hsa-miR-30e-5p HGF -0.07 0.97968 -0.22 0.64343 mirMAP -0.58 0.00239 NA
48 hsa-miR-335-3p HGF -0.24 0.8845 -0.22 0.64343 mirMAP -0.39 0.00043 NA
49 hsa-miR-338-3p HGF 0.49 0.78848 -0.22 0.64343 miRanda -0.3 0.00119 NA
50 hsa-miR-33a-3p HGF -0.79 0.01052 -0.22 0.64343 mirMAP -0.49 0 NA
51 hsa-miR-421 HGF -0.18 0.7347 -0.22 0.64343 miRanda -0.35 0.00289 NA
52 hsa-miR-429 HGF -0.46 0.80624 -0.22 0.64343 miRanda -0.63 0 NA
53 hsa-miR-582-5p HGF -0.4 0.58123 -0.22 0.64343 PITA -0.65 0 NA
54 hsa-miR-590-3p HGF -0.28 0.59127 -0.22 0.64343 miRanda; mirMAP -0.74 0 NA
55 hsa-miR-590-5p HGF -0.55 0.47274 -0.22 0.64343 miRanda -0.82 0 NA
56 hsa-miR-651-5p HGF -0.57 0.17254 -0.22 0.64343 MirTarget -0.45 0 NA
57 hsa-miR-7-1-3p HGF -0.46 0.6659 -0.22 0.64343 mirMAP -0.71 0 NA
58 hsa-miR-106a-5p HIF1A -0.2 0.80221 -0.18 0.90824 MirTarget -0.21 0 NA
59 hsa-miR-106b-5p HIF1A -0.3 0.86929 -0.18 0.90824 MirTarget -0.24 0 NA
60 hsa-miR-143-5p HIF1A 0.11 0.93336 -0.18 0.90824 MirTarget -0.16 9.0E-5 NA
61 hsa-miR-17-5p HIF1A -0.18 0.93454 -0.18 0.90824 miRTarBase; MirTarget; TargetScan -0.22 0 NA
62 hsa-miR-18a-5p HIF1A -0.5 0.61264 -0.18 0.90824 miRNAWalker2 validate; MirTarget -0.15 1.0E-5 25069832 Last clinically relevant correlations between miR-18a HIF1A hypoxia-responsive gene expression and distant metastasis-free survival DMFS were assessed using published expression array breast tumors data sets; We identified HIF1A as a direct target of miR-18a; Analysis of previously published data revealed that higher expression of HIF1A and a panel of hypoxic genes is associated with shorter DMFS interval in patients with basal-like breast tumors and that within this subtype miR-18a expression is inversely correlated with hypoxic gene expression; The results of this study reveal a novel role for miR-18a in targeting HIF1A and repressing metastasis of basal-like breast tumors
63 hsa-miR-18b-5p HIF1A -0.05 0.89998 -0.18 0.90824 MirTarget -0.12 0.00029 NA
64 hsa-miR-20a-5p HIF1A -0.18 0.92812 -0.18 0.90824 miRNAWalker2 validate; miRTarBase; MirTarget -0.19 0 22901144 Correlation analysis showed that the key miRNAs miR-20a and miR-20b negatively correlated with the target proteins VEGF-A and HIF-1alpha
65 hsa-miR-28-5p HIF1A -0.11 0.9406 -0.18 0.90824 miRanda -0.42 0.00044 NA
66 hsa-miR-33a-5p HIF1A -0.21 0.85331 -0.18 0.90824 miRNAWalker2 validate -0.13 0 NA
67 hsa-miR-361-5p HIF1A -0.14 0.9415 -0.18 0.90824 miRanda -0.36 0 NA
68 hsa-miR-424-5p HIF1A 0.25 0.87015 -0.18 0.90824 miRNAWalker2 validate; miRTarBase -0.13 0.00059 NA
69 hsa-miR-660-5p HIF1A -0.48 0.69408 -0.18 0.90824 MirTarget -0.21 0 NA
70 hsa-miR-93-5p HIF1A -0.61 0.8253 -0.18 0.90824 MirTarget -0.14 0.00488 NA
71 hsa-miR-15a-5p HMGA2 -0.07 0.96484 0.66 0.45742 miRTarBase; MirTarget -0.31 0.00856 NA
72 hsa-miR-139-5p HNRNPAB -0.08 0.92869 -0.19 0.92051 miRanda -0.15 3.0E-5 NA
73 hsa-let-7a-3p LEF1 -0.22 0.85543 0.37 0.67217 miRNATAP -0.38 4.0E-5 NA
74 hsa-miR-26b-5p LEF1 -0.02 0.99038 0.37 0.67217 miRNATAP -0.42 0.00016 24785257 miR26b is downregulated in several cancers and tumors and miR26b directly targets the lymphoid enhancer factor 1 Lef13'UTR and inhibits endogenous Lef1 expression; We report that miR26b expression is associated with human colon cancer through the regulation of LEF1 expression in colon cancer cells; Analyses of multiple colon cancer cell lines revealed an inverse correlation between miR26b and LEF1 expression; Normal human colon cells express low levels of LEF1 and high levels of miR26b; however human colon cancer cells have decreased miR26b expression and increased LEF1 expression; We demonstrate that miR26b expression is a potent inhibitor of colon cancer cell proliferation and significantly decreases LEF1 expression; Analyses of human colon cancer databases also demonstrated a link between miR26b and LEF1 expression
75 hsa-miR-335-3p LEF1 -0.24 0.8845 0.37 0.67217 mirMAP -0.22 0.0045 NA
76 hsa-miR-33a-3p LEF1 -0.79 0.01052 0.37 0.67217 miRNATAP -0.24 0.00083 NA
77 hsa-miR-590-3p LEF1 -0.28 0.59127 0.37 0.67217 PITA; miRanda; mirMAP -0.41 0 NA
78 hsa-miR-7-1-3p LEF1 -0.46 0.6659 0.37 0.67217 mirMAP -0.37 0 NA
79 hsa-let-7a-3p LIMS1 -0.22 0.85543 -0.28 0.76944 mirMAP -0.28 0 NA
80 hsa-let-7f-1-3p LIMS1 -0.31 0.69341 -0.28 0.76944 mirMAP -0.19 0.002 NA
81 hsa-miR-140-5p LIMS1 -0.23 0.84733 -0.28 0.76944 miRanda -0.25 3.0E-5 NA
82 hsa-miR-148b-5p LIMS1 -0.24 0.43926 -0.28 0.76944 MirTarget -0.15 8.0E-5 NA
83 hsa-miR-186-5p LIMS1 -0.32 0.85413 -0.28 0.76944 mirMAP -0.18 0.0024 NA
84 hsa-miR-192-5p LIMS1 -0.12 0.97293 -0.28 0.76944 miRNAWalker2 validate; MirTarget -0.13 7.0E-5 NA
85 hsa-miR-193a-3p LIMS1 -0.25 0.65436 -0.28 0.76944 MirTarget; miRanda -0.18 0 NA
86 hsa-miR-193b-3p LIMS1 0.07 0.95148 -0.28 0.76944 MirTarget -0.2 0 NA
87 hsa-miR-221-3p LIMS1 0.09 0.95912 -0.28 0.76944 miRNAWalker2 validate; MirTarget -0.26 0 NA
88 hsa-miR-222-3p LIMS1 -0.03 0.98401 -0.28 0.76944 MirTarget -0.23 0 NA
89 hsa-miR-29a-3p LIMS1 0.01 0.99698 -0.28 0.76944 MirTarget; miRNATAP -0.39 0 NA
90 hsa-miR-29b-3p LIMS1 -0.1 0.95899 -0.28 0.76944 MirTarget; miRNATAP -0.24 0 NA
91 hsa-miR-30b-5p LIMS1 -0.01 0.99462 -0.28 0.76944 MirTarget -0.31 0 NA
92 hsa-miR-30c-5p LIMS1 -0.3 0.86581 -0.28 0.76944 MirTarget -0.39 0 NA
93 hsa-miR-30d-3p LIMS1 -0.12 0.81491 -0.28 0.76944 mirMAP -0.13 0.00393 NA
94 hsa-miR-30e-5p LIMS1 -0.07 0.97968 -0.28 0.76944 MirTarget -0.23 0.00032 NA
95 hsa-miR-32-3p LIMS1 -0.57 0.13133 -0.28 0.76944 mirMAP -0.18 0 NA
96 hsa-miR-337-3p LIMS1 0.23 0.81558 -0.28 0.76944 mirMAP -0.17 0.00072 NA
97 hsa-miR-33a-3p LIMS1 -0.79 0.01052 -0.28 0.76944 MirTarget -0.12 0.00095 NA
98 hsa-miR-429 LIMS1 -0.46 0.80624 -0.28 0.76944 miRanda; miRNATAP -0.16 0 NA
99 hsa-miR-495-3p LIMS1 0 0.99753 -0.28 0.76944 mirMAP -0.16 0.00192 NA
100 hsa-miR-505-3p LIMS1 -0.47 0.69038 -0.28 0.76944 miRNAWalker2 validate; MirTarget -0.25 0 NA
101 hsa-miR-590-3p LIMS1 -0.28 0.59127 -0.28 0.76944 miRNAWalker2 validate; miRanda -0.17 0 NA
102 hsa-miR-7-1-3p LIMS1 -0.46 0.6659 -0.28 0.76944 mirMAP -0.13 0.00194 NA
103 hsa-miR-96-5p LIMS1 0.09 0.92309 -0.28 0.76944 TargetScan; miRNATAP -0.18 0 NA
104 hsa-miR-192-5p LOXL2 -0.12 0.97293 0.41 0.76469 miRNAWalker2 validate -0.26 0 NA
105 hsa-miR-193a-3p LOXL2 -0.25 0.65436 0.41 0.76469 miRanda -0.21 0.00134 NA
106 hsa-miR-28-5p LOXL2 -0.11 0.9406 0.41 0.76469 miRanda -0.58 0.00237 NA
107 hsa-miR-361-5p LOXL2 -0.14 0.9415 0.41 0.76469 miRanda -0.41 0.0007 NA
108 hsa-let-7d-5p LOXL3 -0.14 0.93416 0.16 0.77143 miRNATAP -0.31 0.00126 NA
109 hsa-let-7g-5p LOXL3 -0.2 0.92299 0.16 0.77143 miRNATAP -0.51 0 NA
110 hsa-miR-2110 LOXL3 -0.32 0.25098 0.16 0.77143 miRNATAP -0.2 0.00044 NA
111 hsa-miR-29a-5p LOXL3 -0.32 0.60044 0.16 0.77143 mirMAP -0.23 2.0E-5 NA
112 hsa-miR-320a LOXL3 -0.42 0.8402 0.16 0.77143 miRanda -0.22 0.00196 NA
113 hsa-miR-320b LOXL3 -0.24 0.85922 0.16 0.77143 miRanda -0.18 0.00602 NA
114 hsa-miR-320c LOXL3 -0.58 0.1136 0.16 0.77143 miRanda -0.14 0.00368 NA
115 hsa-miR-34a-5p LOXL3 -0.5 0.74203 0.16 0.77143 MirTarget; miRNATAP -0.27 2.0E-5 NA
116 hsa-miR-362-5p LOXL3 -0.27 0.75202 0.16 0.77143 TargetScan -0.27 0 NA
117 hsa-miR-502-5p LOXL3 -0.71 0.02613 0.16 0.77143 miRNATAP -0.17 0.00048 NA
118 hsa-miR-939-5p LOXL3 -0.31 0.30445 0.16 0.77143 MirTarget -0.17 0.00113 NA
119 hsa-miR-942-5p LOXL3 -0.51 0.50778 0.16 0.77143 MirTarget -0.16 0.00096 NA
120 hsa-miR-369-3p RBPJ 0.12 0.8323 -0.17 0.87141 MirTarget -0.1 0.00013 NA
121 hsa-miR-374b-5p RBPJ -0.29 0.8357 -0.17 0.87141 mirMAP -0.11 0.00381 NA
122 hsa-let-7a-3p SNAI1 -0.22 0.85543 0.27 0.68887 miRNATAP -0.24 0.00029 NA
123 hsa-let-7b-3p SNAI1 -0.29 0.81216 0.27 0.68887 miRNATAP -0.34 4.0E-5 NA
124 hsa-miR-26b-5p SNAI1 -0.02 0.99038 0.27 0.68887 miRNAWalker2 validate -0.32 5.0E-5 NA
125 hsa-miR-30b-5p SNAI1 -0.01 0.99462 0.27 0.68887 miRTarBase; miRNATAP -0.18 0.00253 NA
126 hsa-miR-30c-5p SNAI1 -0.3 0.86581 0.27 0.68887 miRTarBase; miRNATAP -0.34 5.0E-5 NA
127 hsa-miR-30d-5p SNAI1 -0.17 0.95173 0.27 0.68887 miRTarBase; miRNATAP -0.24 0.00153 26501435 miR 30d Blocked Transforming Growth Factor β1 Induced Epithelial Mesenchymal Transition by Targeting Snail in Ovarian Cancer Cells; Luciferase activity assay was performed to verify the direct inhibition of Snail by miR-30d; Furthermore Snail was identified as the direct target of miR-30d; Our results revealed that miR-30d functioned as a suppressor of ovarian cancer progression by decreasing Snail expression and thus blocking TGF-β1-induced EMT process suggesting the potentiality of miR-30d analogs to be used as therapeutics for ovarian cancer
128 hsa-miR-30e-5p SNAI1 -0.07 0.97968 0.27 0.68887 miRTarBase -0.5 0 NA
129 hsa-miR-335-5p SNAI1 -0.03 0.97338 0.27 0.68887 miRNAWalker2 validate -0.14 0.00926 NA
130 hsa-miR-590-5p SNAI1 -0.55 0.47274 0.27 0.68887 miRanda -0.17 0.00108 NA
131 hsa-miR-126-5p SNAI2 0.08 0.95664 0.21 0.75191 MirTarget -0.29 0.00299 NA
132 hsa-miR-140-5p SNAI2 -0.23 0.84733 0.21 0.75191 miRanda -0.39 0.00041 25322669; 27597739 Down regulation of miR 140 induces EMT and promotes invasion by targeting Slug in esophageal cancer; Slug a target gene of miR-140 was examined by luciferase assay and Western blot; miR-140 may regulate the cell invasion of EC via controlling Slug expression;Mechanistically Unigene56159 could directly bind to miR-140-5p and effectively act as a competing endogenous RNA ceRNA for miR-140-5p to de-repress the expression of the target gene Slug
133 hsa-miR-148b-3p SNAI2 -0.2 0.91188 0.21 0.75191 miRNAWalker2 validate -0.35 0.00144 NA
134 hsa-miR-182-5p SNAI2 -0.1 0.97338 0.21 0.75191 miRNAWalker2 validate; miRNATAP -0.19 0.00407 NA
135 hsa-miR-200b-3p SNAI2 -0.43 0.86396 0.21 0.75191 TargetScan -0.5 0 NA
136 hsa-miR-200c-3p SNAI2 -0.44 0.88712 0.21 0.75191 miRNATAP -0.42 0 NA
137 hsa-miR-203a-3p SNAI2 -0.27 0.93159 0.21 0.75191 MirTarget -0.23 2.0E-5 26194864; 25871397; 22393463; 26819680 miR 203 suppression in gastric carcinoma promotes Slug mediated cancer metastasis; Here we analyzed the levels of miR-203 and Slug in the GC specimen and studied their correlation; We analyzed the binding of miR-203 to the 3'-UTR of Slug messenger RNA mRNA and its effects on Slug translation by bioinformatics analysis and by luciferase-reporter assay respectively; We found that in GC miR-203 levels were significantly decreased and Slug levels were significantly increased; miR-203 and Slug inversely correlated in patients' specimen; Bioinformatic analysis predicted that miR-203 may target the 3'-UTR of Slug mRNA to inhibit its translation which was confirmed by luciferase-reporter assay; Overexpression of miR-203 inhibited Slug and cell invasiveness while depletion of miR-203 increased Slug and cell invasiveness;MiR 203 downregulation is responsible for chemoresistance in human glioblastoma by promoting epithelial mesenchymal transition via SNAI2; SNAI2 was identified as a direct target gene of miR-203; In GBM patients miR-203 expression was inversely related to SNAI2 expression and those tumors with low expression of miR-203 experienced poorer clinical outcomes; Our findings indicate that re-expression of miR-203 or targeting SNAI2 might serve as potential therapeutic approaches to overcome chemotherapy resistance in GBM;Epigenetic Silencing of miR 203 Upregulates SNAI2 and Contributes to the Invasiveness of Malignant Breast Cancer Cells; These results suggest that in malignant breast cancer cells miR-203 is epigenetically silenced and the silencing promotes tumor cell growth and invasion at least in part by upregulating the SNAI2 transcription factor;miR-203 expression was downregulated whereas expression of its target gene Snai2 was upregulated in human ovarian serous carcinoma tissue as compared to normal ovaries; miR-203 functions as a tumor suppressor by down regulating Snai2 in ovarian cancer
138 hsa-miR-320a SNAI2 -0.42 0.8402 0.21 0.75191 miRanda -0.33 0.00019 NA
139 hsa-miR-320b SNAI2 -0.24 0.85922 0.21 0.75191 miRanda -0.3 0.00018 NA
140 hsa-miR-320c SNAI2 -0.58 0.1136 0.21 0.75191 miRanda -0.17 0.00321 NA
141 hsa-miR-330-3p SNAI2 0 0.9945 0.21 0.75191 PITA -0.23 0.00568 NA
142 hsa-miR-335-3p SNAI2 -0.24 0.8845 0.21 0.75191 mirMAP -0.3 1.0E-5 NA
143 hsa-miR-33a-3p SNAI2 -0.79 0.01052 0.21 0.75191 MirTarget -0.3 0 NA
144 hsa-miR-375 SNAI2 -0.69 0.83172 0.21 0.75191 miRanda -0.24 0 NA
145 hsa-miR-421 SNAI2 -0.18 0.7347 0.21 0.75191 miRanda -0.24 0.00067 NA
146 hsa-miR-429 SNAI2 -0.46 0.80624 0.21 0.75191 PITA; miRanda; miRNATAP -0.44 0 NA
147 hsa-miR-532-5p SNAI2 -0.35 0.87895 0.21 0.75191 PITA -0.32 1.0E-5 NA
148 hsa-miR-590-3p SNAI2 -0.28 0.59127 0.21 0.75191 PITA; miRanda; mirMAP -0.39 0 NA
149 hsa-miR-96-5p SNAI2 0.09 0.92309 0.21 0.75191 miRNATAP -0.38 0 NA
150 hsa-let-7b-5p SOX9 -0.23 0.93895 -0.2 0.91353 miRNAWalker2 validate -0.19 0.00744 NA

Over-represented Gene Ontology Biological Process

NumGOOverlapSizeP ValueAdj. P Value
1 EPITHELIAL TO MESENCHYMAL TRANSITION 26 56 4.06e-70 1.889e-66
2 MESENCHYMAL CELL DIFFERENTIATION 26 134 2.279e-58 5.301e-55
3 MESENCHYME DEVELOPMENT 26 190 4.46e-54 5.188e-51
4 STEM CELL DIFFERENTIATION 26 190 4.46e-54 5.188e-51
5 CELL MORPHOGENESIS INVOLVED IN DIFFERENTIATION 26 513 2.31e-42 2.149e-39
6 CELLULAR COMPONENT MORPHOGENESIS 26 900 6.796e-36 5.27e-33
7 CELL DEVELOPMENT 26 1426 1.224e-30 8.137e-28
8 TISSUE DEVELOPMENT 26 1518 6.307e-30 3.668e-27
9 TISSUE MORPHOGENESIS 18 533 4.443e-23 2.297e-20
10 MORPHOGENESIS OF AN EPITHELIUM 15 400 1.597e-19 7.43e-17
11 REGULATION OF CARTILAGE DEVELOPMENT 10 63 2.32e-19 9.813e-17
12 MESENCHYME MORPHOGENESIS 9 38 3.537e-19 1.371e-16
13 REGULATION OF STEM CELL DIFFERENTIATION 11 113 8.183e-19 2.929e-16
14 RESPONSE TO GROWTH FACTOR 15 475 2.109e-18 7.008e-16
15 POSITIVE REGULATION OF STEM CELL DIFFERENTIATION 9 50 5.386e-18 1.566e-15
16 REGULATION OF ANATOMICAL STRUCTURE MORPHOGENESIS 18 1021 5.085e-18 1.566e-15
17 ORGAN MORPHOGENESIS 17 841 7.514e-18 2.057e-15
18 GLAND DEVELOPMENT 14 395 8.512e-18 2.2e-15
19 HEART MORPHOGENESIS 12 212 1.247e-17 2.909e-15
20 EMBRYONIC ORGAN DEVELOPMENT 14 406 1.251e-17 2.909e-15
21 POSITIVE REGULATION OF DEVELOPMENTAL PROCESS 18 1142 3.697e-17 8.192e-15
22 ANATOMICAL STRUCTURE FORMATION INVOLVED IN MORPHOGENESIS 17 957 6.548e-17 1.385e-14
23 POSITIVE REGULATION OF GENE EXPRESSION 20 1733 7.112e-17 1.439e-14
24 NEGATIVE REGULATION OF GENE EXPRESSION 19 1493 1.376e-16 2.502e-14
25 REGULATION OF CELL DIFFERENTIATION 19 1492 1.359e-16 2.502e-14
26 REGULATION OF OSSIFICATION 11 178 1.398e-16 2.502e-14
27 POSITIVE REGULATION OF CELL DIFFERENTIATION 16 823 2.118e-16 3.649e-14
28 CELL MOTILITY 16 835 2.659e-16 4.267e-14
29 LOCALIZATION OF CELL 16 835 2.659e-16 4.267e-14
30 REGULATION OF EPITHELIAL CELL PROLIFERATION 12 285 4.498e-16 6.976e-14
31 EMBRYO DEVELOPMENT 16 894 7.777e-16 1.167e-13
32 CARDIAC EPITHELIAL TO MESENCHYMAL TRANSITION 7 24 8.848e-16 1.287e-13
33 POSITIVE REGULATION OF LOCOMOTION 13 420 1.043e-15 1.471e-13
34 REGULATION OF STEM CELL PROLIFERATION 9 88 1.193e-15 1.633e-13
35 POSITIVE REGULATION OF CELLULAR COMPONENT ORGANIZATION 17 1152 1.439e-15 1.913e-13
36 EPITHELIUM DEVELOPMENT 16 945 1.856e-15 2.399e-13
37 REGULATION OF CELLULAR COMPONENT MOVEMENT 15 771 2.81e-15 3.534e-13
38 SKELETAL SYSTEM DEVELOPMENT 13 455 2.933e-15 3.591e-13
39 CARDIOVASCULAR SYSTEM DEVELOPMENT 15 788 3.873e-15 4.506e-13
40 CIRCULATORY SYSTEM DEVELOPMENT 15 788 3.873e-15 4.506e-13
41 HEART DEVELOPMENT 13 466 3.99e-15 4.528e-13
42 REGULATION OF ORGAN MORPHOGENESIS 11 242 4.268e-15 4.621e-13
43 REGULATION OF CELL PROLIFERATION 18 1496 4.27e-15 4.621e-13
44 POSITIVE REGULATION OF BIOSYNTHETIC PROCESS 19 1805 4.618e-15 4.883e-13
45 NEGATIVE REGULATION OF NITROGEN COMPOUND METABOLIC PROCESS 18 1517 5.449e-15 5.634e-13
46 REGULATION OF CELL DEVELOPMENT 15 836 9.237e-15 9.343e-13
47 POSITIVE REGULATION OF EPITHELIAL TO MESENCHYMAL TRANSITION 7 34 1.364e-14 1.35e-12
48 REGULATION OF EPITHELIAL TO MESENCHYMAL TRANSITION 8 67 1.533e-14 1.486e-12
49 LOCOMOTION 16 1114 2.421e-14 2.253e-12
50 REGULATION OF BINDING 11 283 2.4e-14 2.253e-12
51 EMBRYONIC MORPHOGENESIS 13 539 2.589e-14 2.362e-12
52 REGULATION OF MULTICELLULAR ORGANISMAL DEVELOPMENT 18 1672 2.974e-14 2.661e-12
53 TUBE DEVELOPMENT 13 552 3.513e-14 3.084e-12
54 NEGATIVE REGULATION OF MULTICELLULAR ORGANISMAL PROCESS 15 983 9.877e-14 8.511e-12
55 TUBE MORPHOGENESIS 11 323 1.024e-13 8.666e-12
56 PALATE DEVELOPMENT 8 85 1.115e-13 9.263e-12
57 CARTILAGE DEVELOPMENT 9 147 1.373e-13 1.121e-11
58 CELLULAR RESPONSE TO ENDOGENOUS STIMULUS 15 1008 1.424e-13 1.142e-11
59 DIGESTIVE SYSTEM DEVELOPMENT 9 148 1.461e-13 1.152e-11
60 NEGATIVE REGULATION OF DEVELOPMENTAL PROCESS 14 801 1.509e-13 1.17e-11
61 REGULATION OF CELL MORPHOGENESIS INVOLVED IN DIFFERENTIATION 11 337 1.629e-13 1.243e-11
62 ENDOCARDIAL CUSHION MORPHOGENESIS 6 22 1.908e-13 1.387e-11
63 POSITIVE REGULATION OF CELL PROLIFERATION 14 814 1.88e-13 1.387e-11
64 POSITIVE REGULATION OF CELL DEVELOPMENT 12 472 1.86e-13 1.387e-11
65 MOVEMENT OF CELL OR SUBCELLULAR COMPONENT 16 1275 1.964e-13 1.406e-11
66 SENSORY ORGAN DEVELOPMENT 12 493 3.112e-13 2.194e-11
67 POSITIVE REGULATION OF CELL MORPHOGENESIS INVOLVED IN DIFFERENTIATION 9 162 3.332e-13 2.314e-11
68 REGULATION OF MORPHOGENESIS OF A BRANCHING STRUCTURE 7 53 3.846e-13 2.632e-11
69 CELL PROLIFERATION 13 672 4.315e-13 2.91e-11
70 NEGATIVE REGULATION OF RESPONSE TO STIMULUS 16 1360 5.318e-13 3.535e-11
71 NEGATIVE REGULATION OF CARTILAGE DEVELOPMENT 6 26 5.866e-13 3.844e-11
72 AXIS ELONGATION 6 27 7.536e-13 4.87e-11
73 POSITIVE REGULATION OF MULTICELLULAR ORGANISMAL PROCESS 16 1395 7.865e-13 5.013e-11
74 FORMATION OF PRIMARY GERM LAYER 8 110 9.302e-13 5.849e-11
75 REGULATION OF HEART MORPHOGENESIS 6 29 1.207e-12 7.49e-11
76 EMBRYO DEVELOPMENT ENDING IN BIRTH OR EGG HATCHING 12 554 1.23e-12 7.531e-11
77 REPRODUCTIVE SYSTEM DEVELOPMENT 11 408 1.307e-12 7.901e-11
78 NEGATIVE REGULATION OF EPITHELIAL CELL PROLIFERATION 8 115 1.338e-12 7.979e-11
79 NEGATIVE REGULATION OF CELL COMMUNICATION 15 1192 1.62e-12 9.54e-11
80 CONNECTIVE TISSUE DEVELOPMENT 9 194 1.71e-12 9.946e-11
81 REGULATION OF CELL DEATH 16 1472 1.795e-12 1.031e-10
82 MESODERM MORPHOGENESIS 7 66 1.922e-12 1.078e-10
83 REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 17 1784 1.906e-12 1.078e-10
84 ENDOCARDIAL CUSHION DEVELOPMENT 6 32 2.297e-12 1.272e-10
85 IN UTERO EMBRYONIC DEVELOPMENT 10 311 3.05e-12 1.67e-10
86 PATHWAY RESTRICTED SMAD PROTEIN PHOSPHORYLATION 5 13 3.154e-12 1.707e-10
87 DEVELOPMENTAL PROCESS INVOLVED IN REPRODUCTION 12 602 3.261e-12 1.724e-10
88 POSITIVE REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 14 1004 3.241e-12 1.724e-10
89 CELLULAR RESPONSE TO ORGANIC SUBSTANCE 17 1848 3.378e-12 1.766e-10
90 CELL FATE COMMITMENT 9 227 7.047e-12 3.603e-10
91 NEGATIVE REGULATION OF CELL PROLIFERATION 12 643 7.047e-12 3.603e-10
92 RESPONSE TO TRANSFORMING GROWTH FACTOR BETA 8 144 8.311e-12 4.204e-10
93 REGULATION OF CANONICAL WNT SIGNALING PATHWAY 9 236 9.992e-12 4.999e-10
94 EPITHELIAL CELL DIFFERENTIATION 11 495 1.056e-11 5.229e-10
95 NEGATIVE REGULATION OF CELL DEATH 13 872 1.157e-11 5.667e-10
96 POSITIVE REGULATION OF EPITHELIAL CELL PROLIFERATION 8 154 1.429e-11 6.928e-10
97 GASTRULATION 8 155 1.506e-11 7.223e-10
98 RESPONSE TO ENDOGENOUS STIMULUS 15 1450 2.699e-11 1.282e-09
99 DIGESTIVE TRACT MORPHOGENESIS 6 48 3.068e-11 1.442e-09
100 REGULATION OF CELL MORPHOGENESIS 11 552 3.405e-11 1.584e-09
101 NEGATIVE REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 12 740 3.615e-11 1.665e-09
102 GROWTH 10 410 4.659e-11 2.125e-09
103 DEVELOPMENTAL GROWTH INVOLVED IN MORPHOGENESIS 7 104 5.08e-11 2.295e-09
104 PATTERN SPECIFICATION PROCESS 10 418 5.63e-11 2.519e-09
105 COLUMNAR CUBOIDAL EPITHELIAL CELL DIFFERENTIATION 7 111 8.075e-11 3.578e-09
106 UROGENITAL SYSTEM DEVELOPMENT 9 299 8.272e-11 3.631e-09
107 NEGATIVE REGULATION OF CELL DIFFERENTIATION 11 609 9.733e-11 4.232e-09
108 POSITIVE REGULATION OF RESPONSE TO STIMULUS 16 1929 1.097e-10 4.726e-09
109 REGULATION OF WNT SIGNALING PATHWAY 9 310 1.14e-10 4.867e-09
110 REGIONALIZATION 9 311 1.173e-10 4.963e-09
111 MESODERM DEVELOPMENT 7 118 1.246e-10 5.224e-09
112 REGULATION OF CELL ADHESION 11 629 1.373e-10 5.654e-09
113 POSITIVE REGULATION OF STEM CELL PROLIFERATION 6 61 1.373e-10 5.654e-09
114 REGULATION OF GROWTH 11 633 1.469e-10 5.996e-09
115 REGULATION OF INTRACELLULAR SIGNAL TRANSDUCTION 15 1656 1.782e-10 7.153e-09
116 SKIN DEVELOPMENT 8 211 1.783e-10 7.153e-09
117 POSITIVE REGULATION OF BINDING 7 127 2.096e-10 8.337e-09
118 DEVELOPMENTAL GROWTH 9 333 2.151e-10 8.48e-09
119 BRANCHING MORPHOGENESIS OF AN EPITHELIAL TUBE 7 131 2.609e-10 1.02e-08
120 NEUROGENESIS 14 1402 2.818e-10 1.093e-08
121 REGULATION OF CELLULAR RESPONSE TO GROWTH FACTOR STIMULUS 8 229 3.42e-10 1.315e-08
122 SKIN EPIDERMIS DEVELOPMENT 6 71 3.511e-10 1.339e-08
123 BLOOD VESSEL MORPHOGENESIS 9 364 4.722e-10 1.786e-08
124 PROTEIN PHOSPHORYLATION 12 944 5.971e-10 2.24e-08
125 REGULATION OF MESENCHYMAL CELL PROLIFERATION 5 34 6.695e-10 2.492e-08
126 OSSIFICATION 8 251 7.075e-10 2.613e-08
127 AMEBOIDAL TYPE CELL MIGRATION 7 154 8.141e-10 2.983e-08
128 HAIR CYCLE 6 83 9.158e-10 3.253e-08
129 POSITIVE REGULATION OF CELL COMMUNICATION 14 1532 9.071e-10 3.253e-08
130 EMBRYONIC PLACENTA DEVELOPMENT 6 83 9.158e-10 3.253e-08
131 MOLTING CYCLE 6 83 9.158e-10 3.253e-08
132 POSITIVE REGULATION OF OSSIFICATION 6 84 9.854e-10 3.473e-08
133 REGULATION OF CELLULAR COMPONENT BIOGENESIS 11 767 1.121e-09 3.923e-08
134 NEGATIVE REGULATION OF CANONICAL WNT SIGNALING PATHWAY 7 162 1.161e-09 4.031e-08
135 IMMUNE SYSTEM DEVELOPMENT 10 582 1.408e-09 4.852e-08
136 MORPHOGENESIS OF A BRANCHING STRUCTURE 7 167 1.436e-09 4.912e-08
137 REGULATION OF PROTEIN BINDING 7 168 1.497e-09 5.054e-08
138 RESPONSE TO ABIOTIC STIMULUS 12 1024 1.51e-09 5.054e-08
139 MESONEPHROS DEVELOPMENT 6 90 1.502e-09 5.054e-08
140 REPRODUCTION 13 1297 1.588e-09 5.277e-08
141 EMBRYONIC ORGAN MORPHOGENESIS 8 279 1.63e-09 5.38e-08
142 POSITIVE REGULATION OF PHOSPHATE METABOLIC PROCESS 12 1036 1.724e-09 5.608e-08
143 POSITIVE REGULATION OF PHOSPHORUS METABOLIC PROCESS 12 1036 1.724e-09 5.608e-08
144 POSITIVE REGULATION OF CELL DEATH 10 605 2.045e-09 6.607e-08
145 CANONICAL WNT SIGNALING PATHWAY 6 95 2.087e-09 6.697e-08
146 MUSCLE STRUCTURE DEVELOPMENT 9 432 2.125e-09 6.774e-08
147 ANGIOGENESIS 8 293 2.397e-09 7.586e-08
148 POSITIVE REGULATION OF TRANSMEMBRANE RECEPTOR PROTEIN SERINE THREONINE KINASE SIGNALING PATHWAY 6 100 2.85e-09 8.961e-08
149 REGULATION OF CHONDROCYTE DIFFERENTIATION 5 46 3.264e-09 1.019e-07
150 REGULATION OF MUSCLE TISSUE DEVELOPMENT 6 103 3.41e-09 1.044e-07
151 POSITIVE REGULATION OF EPITHELIAL CELL MIGRATION 6 103 3.41e-09 1.044e-07
152 REGULATION OF MUSCLE ORGAN DEVELOPMENT 6 103 3.41e-09 1.044e-07
153 CARDIAC CHAMBER MORPHOGENESIS 6 104 3.616e-09 1.1e-07
154 RESPONSE TO OXYGEN LEVELS 8 311 3.827e-09 1.156e-07
155 ANTERIOR POSTERIOR PATTERN SPECIFICATION 7 194 4.08e-09 1.202e-07
156 CARDIAC VENTRICLE DEVELOPMENT 6 106 4.058e-09 1.202e-07
157 PARAXIAL MESODERM DEVELOPMENT 4 16 4.04e-09 1.202e-07
158 CELL SURFACE RECEPTOR SIGNALING PATHWAY INVOLVED IN HEART DEVELOPMENT 4 16 4.04e-09 1.202e-07
159 VASCULATURE DEVELOPMENT 9 469 4.355e-09 1.275e-07
160 NEURON DIFFERENTIATION 11 874 4.41e-09 1.282e-07
161 RESPIRATORY SYSTEM DEVELOPMENT 7 197 4.539e-09 1.304e-07
162 NEGATIVE REGULATION OF WNT SIGNALING PATHWAY 7 197 4.539e-09 1.304e-07
163 REGULATION OF MAPK CASCADE 10 660 4.714e-09 1.346e-07
164 POSITIVE REGULATION OF PROTEIN MODIFICATION PROCESS 12 1135 4.846e-09 1.375e-07
165 RESPONSE TO LIPID 11 888 5.205e-09 1.468e-07
166 BRANCH ELONGATION OF AN EPITHELIUM 4 17 5.278e-09 1.471e-07
167 NEGATIVE REGULATION OF STEM CELL PROLIFERATION 4 17 5.278e-09 1.471e-07
168 EYE DEVELOPMENT 8 326 5.535e-09 1.533e-07
169 NOTCH SIGNALING PATHWAY 6 114 6.3e-09 1.735e-07
170 REGULATION OF TRANSMEMBRANE RECEPTOR PROTEIN SERINE THREONINE KINASE SIGNALING PATHWAY 7 207 6.399e-09 1.751e-07
171 POSITIVE REGULATION OF MOLECULAR FUNCTION 14 1791 6.968e-09 1.896e-07
172 REGULATION OF CELLULAR RESPONSE TO STRESS 10 691 7.312e-09 1.978e-07
173 MAMMARY GLAND DEVELOPMENT 6 117 7.37e-09 1.982e-07
174 CARDIAC MUSCLE TISSUE MORPHOGENESIS 5 54 7.477e-09 1.999e-07
175 OUTFLOW TRACT MORPHOGENESIS 5 56 9.015e-09 2.397e-07
176 HEAD DEVELOPMENT 10 709 9.346e-09 2.471e-07
177 ENDOCRINE SYSTEM DEVELOPMENT 6 123 9.961e-09 2.619e-07
178 REGULATION OF CELL CYCLE 11 949 1.039e-08 2.716e-07
179 NEGATIVE REGULATION OF CHONDROCYTE DIFFERENTIATION 4 20 1.072e-08 2.786e-07
180 KIDNEY EPITHELIUM DEVELOPMENT 6 125 1.098e-08 2.837e-07
181 FOREBRAIN DEVELOPMENT 8 357 1.125e-08 2.892e-07
182 PHOSPHORYLATION 12 1228 1.176e-08 3.006e-07
183 STEM CELL PROLIFERATION 5 60 1.284e-08 3.248e-07
184 REGULATION OF APOPTOTIC SIGNALING PATHWAY 8 363 1.281e-08 3.248e-07
185 MORPHOGENESIS OF EMBRYONIC EPITHELIUM 6 134 1.667e-08 4.192e-07
186 PLACENTA DEVELOPMENT 6 138 1.988e-08 4.974e-07
187 REGULATION OF CYTOKINE PRODUCTION 9 563 2.122e-08 5.281e-07
188 CARDIAC MUSCLE TISSUE DEVELOPMENT 6 140 2.167e-08 5.364e-07
189 REGULATION OF PHOSPHORUS METABOLIC PROCESS 13 1618 2.315e-08 5.7e-07
190 CARDIAC CHAMBER DEVELOPMENT 6 144 2.565e-08 6.25e-07
191 EPIDERMIS DEVELOPMENT 7 253 2.556e-08 6.25e-07
192 MUSCLE ORGAN MORPHOGENESIS 5 70 2.822e-08 6.838e-07
193 POSITIVE REGULATION OF CELLULAR COMPONENT BIOGENESIS 8 406 3.054e-08 7.362e-07
194 REGULATION OF MUSCLE CELL DIFFERENTIATION 6 152 3.544e-08 8.5e-07
195 POSITIVE REGULATION OF MESENCHYMAL CELL PROLIFERATION 4 27 3.858e-08 9.205e-07
196 REGULATION OF PROTEIN MODIFICATION PROCESS 13 1710 4.487e-08 1.065e-06
197 MUSCLE TISSUE DEVELOPMENT 7 275 4.529e-08 1.07e-06
198 SOMITE DEVELOPMENT 5 78 4.887e-08 1.149e-06
199 EPIDERMIS MORPHOGENESIS 4 29 5.212e-08 1.213e-06
200 POSITIVE REGULATION OF CARTILAGE DEVELOPMENT 4 29 5.212e-08 1.213e-06
201 REGULATION OF EPITHELIAL CELL MIGRATION 6 166 5.992e-08 1.387e-06
202 CENTRAL NERVOUS SYSTEM DEVELOPMENT 10 872 6.627e-08 1.527e-06
203 POSITIVE REGULATION OF INTRACELLULAR SIGNAL TRANSDUCTION 10 876 6.919e-08 1.586e-06
204 TISSUE REMODELING 5 87 8.487e-08 1.936e-06
205 POSITIVE REGULATION OF MAPK CASCADE 8 470 9.44e-08 2.143e-06
206 POSITIVE REGULATION OF PROTEIN METABOLIC PROCESS 12 1492 1.025e-07 2.315e-06
207 CELL JUNCTION ORGANIZATION 6 185 1.14e-07 2.563e-06
208 ENZYME LINKED RECEPTOR PROTEIN SIGNALING PATHWAY 9 689 1.198e-07 2.68e-06
209 POSITIVE REGULATION OF CATALYTIC ACTIVITY 12 1518 1.239e-07 2.759e-06
210 TRANSMEMBRANE RECEPTOR PROTEIN SERINE THREONINE KINASE SIGNALING PATHWAY 6 190 1.335e-07 2.958e-06
211 GLAND MORPHOGENESIS 5 97 1.467e-07 3.236e-06
212 REGULATION OF PROTEIN LOCALIZATION 10 950 1.478e-07 3.244e-06
213 EAR DEVELOPMENT 6 195 1.557e-07 3.401e-06
214 POSITIVE REGULATION OF CELL CYCLE 7 332 1.635e-07 3.556e-06
215 WNT SIGNALING PATHWAY CALCIUM MODULATING PATHWAY 4 39 1.789e-07 3.871e-06
216 CAMERA TYPE EYE MORPHOGENESIS 5 101 1.797e-07 3.871e-06
217 NEGATIVE REGULATION OF APOPTOTIC SIGNALING PATHWAY 6 200 1.808e-07 3.876e-06
218 SKELETAL SYSTEM MORPHOGENESIS 6 201 1.862e-07 3.974e-06
219 ODONTOGENESIS 5 105 2.183e-07 4.638e-06
220 PROSTATE GLAND DEVELOPMENT 4 41 2.199e-07 4.651e-06
221 REGULATION OF OSTEOBLAST DIFFERENTIATION 5 112 3.015e-07 6.318e-06
222 REGULATION OF PROTEIN LOCALIZATION TO NUCLEUS 6 218 3.004e-07 6.318e-06
223 EPITHELIAL TO MESENCHYMAL TRANSITION INVOLVED IN ENDOCARDIAL CUSHION FORMATION 3 11 3.196e-07 6.668e-06
224 EXOCRINE SYSTEM DEVELOPMENT 4 45 3.224e-07 6.67e-06
225 REGULATION OF CELLULAR PROTEIN LOCALIZATION 8 552 3.225e-07 6.67e-06
226 POSITIVE REGULATION OF CELL ADHESION 7 376 3.795e-07 7.813e-06
227 TELENCEPHALON DEVELOPMENT 6 228 3.91e-07 8.015e-06
228 REGULATION OF CELL CELL ADHESION 7 380 4.075e-07 8.317e-06
229 REGULATION OF CARDIAC MUSCLE TISSUE DEVELOPMENT 4 48 4.199e-07 8.494e-06
230 POSITIVE REGULATION OF PATHWAY RESTRICTED SMAD PROTEIN PHOSPHORYLATION 4 48 4.199e-07 8.494e-06
231 REGULATION OF MACROPHAGE CYTOKINE PRODUCTION 3 12 4.257e-07 8.576e-06
232 POSITIVE REGULATION OF ORGANELLE ORGANIZATION 8 573 4.282e-07 8.588e-06
233 EMBRYONIC SKELETAL SYSTEM DEVELOPMENT 5 122 4.617e-07 9.221e-06
234 MUSCLE CELL DIFFERENTIATION 6 237 4.907e-07 9.757e-06
235 REGULATION OF CELL GROWTH 7 391 4.938e-07 9.777e-06
236 FACE DEVELOPMENT 4 50 4.961e-07 9.781e-06
237 POSITIVE REGULATION OF GROWTH 6 238 5.029e-07 9.874e-06
238 SENSORY ORGAN MORPHOGENESIS 6 239 5.154e-07 1.008e-05
239 OSTEOBLAST DIFFERENTIATION 5 126 5.421e-07 1.055e-05
240 MESENCHYMAL CELL PROLIFERATION 3 13 5.53e-07 1.072e-05
241 REGULATION OF REPRODUCTIVE PROCESS 5 129 6.093e-07 1.176e-05
242 MAMMARY GLAND EPITHELIUM DEVELOPMENT 4 53 6.291e-07 1.205e-05
243 MESONEPHRIC TUBULE MORPHOGENESIS 4 53 6.291e-07 1.205e-05
244 CELL MIGRATION INVOLVED IN GASTRULATION 3 14 7.032e-07 1.336e-05
245 CONVERGENT EXTENSION 3 14 7.032e-07 1.336e-05
246 CRANIAL SKELETAL SYSTEM DEVELOPMENT 4 55 7.314e-07 1.384e-05
247 POSITIVE REGULATION OF TRANSFERASE ACTIVITY 8 616 7.401e-07 1.394e-05
248 CELL GROWTH 5 135 7.635e-07 1.432e-05
249 POSITIVE REGULATION OF MUSCLE TISSUE DEVELOPMENT 4 56 7.87e-07 1.471e-05
250 EYE MORPHOGENESIS 5 136 7.919e-07 1.474e-05
251 NEGATIVE REGULATION OF CELL CELL ADHESION 5 138 8.513e-07 1.578e-05
252 ENDOCARDIAL CUSHION FORMATION 3 15 8.782e-07 1.615e-05
253 REGULATION OF CELL PROLIFERATION INVOLVED IN HEART MORPHOGENESIS 3 15 8.782e-07 1.615e-05
254 REGULATION OF RESPONSE TO STRESS 11 1468 8.842e-07 1.62e-05
255 RESPONSE TO EXTERNAL STIMULUS 12 1821 8.981e-07 1.639e-05
256 EMBRYONIC PATTERN SPECIFICATION 4 58 9.075e-07 1.649e-05
257 CHONDROCYTE DIFFERENTIATION 4 60 1.041e-06 1.878e-05
258 REGULATION OF PATHWAY RESTRICTED SMAD PROTEIN PHOSPHORYLATION 4 60 1.041e-06 1.878e-05
259 REGULATION OF ORGANELLE ORGANIZATION 10 1178 1.078e-06 1.937e-05
260 RESPONSE TO ESTRADIOL 5 146 1.125e-06 2.013e-05
261 SOMITOGENESIS 4 62 1.189e-06 2.112e-05
262 CARDIAC VENTRICLE MORPHOGENESIS 4 62 1.189e-06 2.112e-05
263 NEUROEPITHELIAL CELL DIFFERENTIATION 4 63 1.269e-06 2.241e-05
264 ACTIVATION OF PROTEIN KINASE ACTIVITY 6 279 1.272e-06 2.241e-05
265 NEGATIVE REGULATION OF ALCOHOL BIOSYNTHETIC PROCESS 3 17 1.31e-06 2.292e-05
266 POSITIVE REGULATION OF EXTRACELLULAR MATRIX ORGANIZATION 3 17 1.31e-06 2.292e-05
267 RESPONSE TO ORGANIC CYCLIC COMPOUND 9 917 1.329e-06 2.315e-05
268 CELLULAR RESPONSE TO LIPID 7 457 1.403e-06 2.435e-05
269 LENS DEVELOPMENT IN CAMERA TYPE EYE 4 66 1.531e-06 2.648e-05
270 NOTOCHORD DEVELOPMENT 3 18 1.571e-06 2.707e-05
271 REGULATION OF TRANSFERASE ACTIVITY 9 946 1.72e-06 2.932e-05
272 REGULATION OF CELL JUNCTION ASSEMBLY 4 68 1.727e-06 2.932e-05
273 ORGAN GROWTH 4 68 1.727e-06 2.932e-05
274 POSITIVE REGULATION OF ENDOTHELIAL CELL PROLIFERATION 4 68 1.727e-06 2.932e-05
275 NEGATIVE REGULATION OF OSSIFICATION 4 69 1.831e-06 3.099e-05
276 REGULATION OF CARDIAC MUSCLE CELL DIFFERENTIATION 3 19 1.864e-06 3.142e-05
277 POSITIVE REGULATION OF KINASE ACTIVITY 7 482 1.999e-06 3.358e-05
278 NEGATIVE REGULATION OF CELL DEVELOPMENT 6 303 2.052e-06 3.427e-05
279 ENDODERM DEVELOPMENT 4 71 2.055e-06 3.427e-05
280 EXTRACELLULAR STRUCTURE ORGANIZATION 6 304 2.092e-06 3.476e-05
281 PHOSPHATE CONTAINING COMPOUND METABOLIC PROCESS 12 1977 2.165e-06 3.584e-05
282 TRACHEA DEVELOPMENT 3 20 2.191e-06 3.615e-05
283 POSITIVE REGULATION OF PROTEIN BINDING 4 73 2.298e-06 3.75e-05
284 EMBRYONIC HEART TUBE DEVELOPMENT 4 73 2.298e-06 3.75e-05
285 APPENDAGE DEVELOPMENT 5 169 2.313e-06 3.75e-05
286 LIMB DEVELOPMENT 5 169 2.313e-06 3.75e-05
287 REGULATION OF NEURAL PRECURSOR CELL PROLIFERATION 4 73 2.298e-06 3.75e-05
288 RESPONSE TO STEROID HORMONE 7 497 2.449e-06 3.957e-05
289 REGULATION OF BIOMINERAL TISSUE DEVELOPMENT 4 75 2.561e-06 4.109e-05
290 NEURAL CREST CELL DIFFERENTIATION 4 75 2.561e-06 4.109e-05
291 RESPONSE TO ACID CHEMICAL 6 319 2.763e-06 4.388e-05
292 GLIOGENESIS 5 175 2.745e-06 4.388e-05
293 REGULATION OF MAP KINASE ACTIVITY 6 319 2.763e-06 4.388e-05
294 DIENCEPHALON DEVELOPMENT 4 77 2.847e-06 4.505e-05
295 SOMATIC STEM CELL DIVISION 3 22 2.955e-06 4.645e-05
296 EMBRYONIC PLACENTA MORPHOGENESIS 3 22 2.955e-06 4.645e-05
297 RENAL TUBULE DEVELOPMENT 4 78 2.998e-06 4.697e-05
298 POSITIVE REGULATION OF ESTABLISHMENT OF PROTEIN LOCALIZATION 7 514 3.06e-06 4.777e-05
299 REGULATION OF NERVOUS SYSTEM DEVELOPMENT 8 750 3.228e-06 5.024e-05
300 CELLULAR RESPONSE TO MECHANICAL STIMULUS 4 80 3.318e-06 5.146e-05
301 REGULATION OF PROTEIN IMPORT 5 183 3.417e-06 5.283e-05
302 RESPONSE TO METAL ION 6 333 3.54e-06 5.454e-05
303 POSITIVE REGULATION OF DNA METABOLIC PROCESS 5 185 3.604e-06 5.535e-05
304 KIDNEY MORPHOGENESIS 4 82 3.663e-06 5.607e-05
305 EPITHELIAL CELL DEVELOPMENT 5 186 3.7e-06 5.645e-05
306 CELL CELL SIGNALING 8 767 3.812e-06 5.797e-05
307 ORGAN REGENERATION 4 83 3.845e-06 5.828e-05
308 NEGATIVE REGULATION OF STEROID METABOLIC PROCESS 3 24 3.877e-06 5.856e-05
309 REGULATION OF DNA METABOLIC PROCESS 6 340 3.99e-06 6.006e-05
310 MYELOID CELL DIFFERENTIATION 5 189 4.002e-06 6.006e-05
311 REGULATION OF KINASE ACTIVITY 8 776 4.156e-06 6.218e-05
312 POSITIVE REGULATION OF CHROMATIN MODIFICATION 4 85 4.229e-06 6.307e-05
313 EPITHELIAL TUBE BRANCHING INVOLVED IN LUNG MORPHOGENESIS 3 25 4.401e-06 6.46e-05
314 LUNG CELL DIFFERENTIATION 3 25 4.401e-06 6.46e-05
315 REGULATION OF TRANSFORMING GROWTH FACTOR BETA PRODUCTION 3 25 4.401e-06 6.46e-05
316 REGULATION OF FIBROBLAST GROWTH FACTOR RECEPTOR SIGNALING PATHWAY 3 25 4.401e-06 6.46e-05
317 POSITIVE REGULATION OF PEPTIDYL THREONINE PHOSPHORYLATION 3 25 4.401e-06 6.46e-05
318 DEVELOPMENTAL MATURATION 5 193 4.433e-06 6.486e-05
319 RESPONSE TO OXYGEN CONTAINING COMPOUND 10 1381 4.552e-06 6.639e-05
320 WNT SIGNALING PATHWAY 6 351 4.791e-06 6.966e-05
321 NEGATIVE REGULATION OF EMBRYONIC DEVELOPMENT 3 26 4.971e-06 7.206e-05
322 SEGMENTATION 4 89 5.082e-06 7.321e-05
323 EPITHELIAL CELL PROLIFERATION 4 89 5.082e-06 7.321e-05
324 REGULATION OF CELL CYCLE PROCESS 7 558 5.255e-06 7.547e-05
325 DEVELOPMENTAL INDUCTION 3 27 5.588e-06 7.951e-05
326 RESPONSE TO LITHIUM ION 3 27 5.588e-06 7.951e-05
327 POSITIVE REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER INVOLVED IN CELLULAR RESPONSE TO CHEMICAL STIMULUS 3 27 5.588e-06 7.951e-05
328 RESPONSE TO ALCOHOL 6 362 5.718e-06 8.112e-05
329 NEPHRON EPITHELIUM DEVELOPMENT 4 93 6.056e-06 8.539e-05
330 REGULATION OF DNA BINDING 4 93 6.056e-06 8.539e-05
331 VENTRICULAR SEPTUM MORPHOGENESIS 3 28 6.253e-06 8.711e-05
332 REGULATION OF NEUROBLAST PROLIFERATION 3 28 6.253e-06 8.711e-05
333 DOPAMINERGIC NEURON DIFFERENTIATION 3 28 6.253e-06 8.711e-05
334 MAMMARY GLAND DUCT MORPHOGENESIS 3 28 6.253e-06 8.711e-05
335 POSITIVE REGULATION OF CYTOKINE PRODUCTION 6 370 6.48e-06 9.001e-05
336 TRANSFORMING GROWTH FACTOR BETA RECEPTOR SIGNALING PATHWAY 4 95 6.591e-06 9.128e-05
337 NEGATIVE REGULATION OF CYTOKINE PRODUCTION 5 211 6.845e-06 9.451e-05
338 MYELOID LEUKOCYTE DIFFERENTIATION 4 96 6.872e-06 9.46e-05
339 REGULATION OF EXTRACELLULAR MATRIX ORGANIZATION 3 29 6.968e-06 9.508e-05
340 STEM CELL DIVISION 3 29 6.968e-06 9.508e-05
341 POSITIVE REGULATION OF CARDIAC MUSCLE TISSUE DEVELOPMENT 3 29 6.968e-06 9.508e-05
342 REGULATION OF ENDOTHELIAL CELL PROLIFERATION 4 98 7.459e-06 0.0001015
343 RESPONSE TO ESTROGEN 5 218 8.021e-06 0.0001088
344 REGULATION OF SMOOTH MUSCLE CELL PROLIFERATION 4 100 8.083e-06 0.0001093
345 REGULATION OF NUCLEOCYTOPLASMIC TRANSPORT 5 220 8.385e-06 0.0001131
346 NEGATIVE REGULATION OF TRANSMEMBRANE RECEPTOR PROTEIN SERINE THREONINE KINASE SIGNALING PATHWAY 4 102 8.744e-06 0.0001176
347 NEGATIVE REGULATION OF CELL ADHESION 5 223 8.954e-06 0.0001201
348 SALIVARY GLAND DEVELOPMENT 3 32 9.434e-06 0.0001258
349 REGULATION OF ORGAN FORMATION 3 32 9.434e-06 0.0001258
350 REGULATION OF FAT CELL DIFFERENTIATION 4 106 1.019e-05 0.0001354
351 EMBRYONIC AXIS SPECIFICATION 3 33 1.037e-05 0.0001367
352 REGULATION OF T CELL APOPTOTIC PROCESS 3 33 1.037e-05 0.0001367
353 EMBRYONIC DIGESTIVE TRACT DEVELOPMENT 3 33 1.037e-05 0.0001367
354 SIGNAL TRANSDUCTION BY PROTEIN PHOSPHORYLATION 6 404 1.07e-05 0.0001406
355 PROTEIN COMPLEX SUBUNIT ORGANIZATION 10 1527 1.115e-05 0.0001461
356 ORGAN FORMATION 3 34 1.136e-05 0.0001481
357 HEART VALVE DEVELOPMENT 3 34 1.136e-05 0.0001481
358 RESPONSE TO HORMONE 8 893 1.166e-05 0.0001516
359 NEGATIVE REGULATION OF GROWTH 5 236 1.178e-05 0.0001527
360 NEGATIVE REGULATION OF MUSCLE ORGAN DEVELOPMENT 3 36 1.353e-05 0.0001735
361 NEGATIVE REGULATION OF MUSCLE TISSUE DEVELOPMENT 3 36 1.353e-05 0.0001735
362 REGULATION OF TRANSCRIPTION REGULATORY REGION DNA BINDING 3 36 1.353e-05 0.0001735
363 HEAD MORPHOGENESIS 3 36 1.353e-05 0.0001735
364 NEPHRON DEVELOPMENT 4 115 1.406e-05 0.0001798
365 POSITIVE REGULATION OF CELL CYCLE PROCESS 5 247 1.468e-05 0.0001866
366 REGULATION OF PEPTIDYL THREONINE PHOSPHORYLATION 3 37 1.472e-05 0.0001866
367 NEGATIVE REGULATION OF EPITHELIAL CELL DIFFERENTIATION 3 37 1.472e-05 0.0001866
368 NEGATIVE REGULATION OF CELL MORPHOGENESIS INVOLVED IN DIFFERENTIATION 4 117 1.505e-05 0.0001904
369 REGULATION OF PEPTIDYL SERINE PHOSPHORYLATION 4 118 1.557e-05 0.0001963
370 NEGATIVE REGULATION OF CELL CYCLE 6 433 1.586e-05 0.0001994
371 COLLAGEN FIBRIL ORGANIZATION 3 38 1.596e-05 0.0001997
372 BONE MINERALIZATION 3 38 1.596e-05 0.0001997
373 POSITIVE REGULATION OF NERVOUS SYSTEM DEVELOPMENT 6 437 1.67e-05 0.0002084
374 IMMUNE SYSTEM PROCESS 11 1984 1.675e-05 0.0002084
375 ANATOMICAL STRUCTURE MATURATION 3 39 1.728e-05 0.0002127
376 NEGATIVE REGULATION OF CELLULAR RESPONSE TO GROWTH FACTOR STIMULUS 4 121 1.719e-05 0.0002127
377 POSITIVE REGULATION OF NUCLEOCYTOPLASMIC TRANSPORT 4 121 1.719e-05 0.0002127
378 GLANDULAR EPITHELIAL CELL DIFFERENTIATION 3 39 1.728e-05 0.0002127
379 MAMMARY GLAND MORPHOGENESIS 3 40 1.866e-05 0.0002285
380 POSITIVE REGULATION OF CELL MATRIX ADHESION 3 40 1.866e-05 0.0002285
381 NEGATIVE REGULATION OF NERVOUS SYSTEM DEVELOPMENT 5 262 1.95e-05 0.0002382
382 REGULATION OF CELLULAR LOCALIZATION 9 1277 1.986e-05 0.0002413
383 CELLULAR RESPONSE TO ABIOTIC STIMULUS 5 263 1.986e-05 0.0002413
384 AGING 5 264 2.023e-05 0.0002451
385 SEX DIFFERENTIATION 5 266 2.097e-05 0.0002535
386 HEPATICOBILIARY SYSTEM DEVELOPMENT 4 128 2.145e-05 0.0002586
387 PITUITARY GLAND DEVELOPMENT 3 42 2.165e-05 0.0002596
388 GENITALIA DEVELOPMENT 3 42 2.165e-05 0.0002596
389 POSITIVE REGULATION OF PROTEIN LOCALIZATION TO NUCLEUS 4 129 2.212e-05 0.0002639
390 TUBE FORMATION 4 129 2.212e-05 0.0002639
391 NEGATIVE REGULATION OF BINDING 4 131 2.35e-05 0.0002797
392 CELLULAR RESPONSE TO ORGANIC CYCLIC COMPOUND 6 465 2.371e-05 0.0002815
393 POSITIVE REGULATION OF CELL DIVISION 4 132 2.421e-05 0.0002867
394 LABYRINTHINE LAYER DEVELOPMENT 3 44 2.493e-05 0.0002922
395 BODY MORPHOGENESIS 3 44 2.493e-05 0.0002922
396 NEGATIVE REGULATION OF LIPID BIOSYNTHETIC PROCESS 3 44 2.493e-05 0.0002922
397 BRANCHING INVOLVED IN URETERIC BUD MORPHOGENESIS 3 44 2.493e-05 0.0002922
398 REGULATION OF PROTEIN SERINE THREONINE KINASE ACTIVITY 6 470 2.518e-05 0.0002944
399 MUSCLE ORGAN DEVELOPMENT 5 277 2.548e-05 0.0002971
400 LUNG MORPHOGENESIS 3 45 2.669e-05 0.0003089
401 VENTRICULAR CARDIAC MUSCLE TISSUE DEVELOPMENT 3 45 2.669e-05 0.0003089
402 REGULATION OF ALCOHOL BIOSYNTHETIC PROCESS 3 45 2.669e-05 0.0003089
403 REGULATION OF HYDROLASE ACTIVITY 9 1327 2.698e-05 0.0003115
404 GLIAL CELL DIFFERENTIATION 4 136 2.723e-05 0.0003136
405 RESPONSE TO INORGANIC SUBSTANCE 6 479 2.802e-05 0.0003219
406 TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 7 724 2.851e-05 0.0003261
407 EMBRYONIC CRANIAL SKELETON MORPHOGENESIS 3 46 2.853e-05 0.0003261
408 REGULATION OF PHOSPHATIDYLINOSITOL 3 KINASE SIGNALING 4 138 2.883e-05 0.0003288
409 NON CANONICAL WNT SIGNALING PATHWAY 4 140 3.05e-05 0.0003462
410 POSITIVE REGULATION OF NEURON APOPTOTIC PROCESS 3 47 3.045e-05 0.0003462
411 ANTERIOR POSTERIOR AXIS SPECIFICATION 3 48 3.245e-05 0.0003673
412 REGULATION OF STEROID BIOSYNTHETIC PROCESS 3 49 3.453e-05 0.0003891
413 CARDIAC SEPTUM MORPHOGENESIS 3 49 3.453e-05 0.0003891
414 REGULATION OF RESPONSE TO DNA DAMAGE STIMULUS 4 145 3.5e-05 0.0003934
415 POSITIVE REGULATION OF CELL GROWTH 4 148 3.792e-05 0.0004241
416 MALE SEX DIFFERENTIATION 4 148 3.792e-05 0.0004241
417 ARTERY MORPHOGENESIS 3 51 3.897e-05 0.0004348
418 POSITIVE REGULATION OF CHROMOSOME ORGANIZATION 4 150 3.996e-05 0.0004448
419 POSITIVE REGULATION OF REPRODUCTIVE PROCESS 3 52 4.132e-05 0.0004577
420 NEGATIVE REGULATION OF RESPONSE TO DNA DAMAGE STIMULUS 3 52 4.132e-05 0.0004577
421 MULTICELLULAR ORGANISM REPRODUCTION 7 768 4.157e-05 0.0004591
422 REGULATION OF PROTEIN TARGETING 5 307 4.164e-05 0.0004591
423 REGULATION OF CHROMATIN ORGANIZATION 4 152 4.209e-05 0.0004618
424 POSITIVE REGULATION OF WNT SIGNALING PATHWAY 4 152 4.209e-05 0.0004618
425 REGULATION OF EXTRINSIC APOPTOTIC SIGNALING PATHWAY 4 153 4.318e-05 0.0004716
426 PALLIUM DEVELOPMENT 4 153 4.318e-05 0.0004716
427 REGULATION OF LYMPHOCYTE APOPTOTIC PROCESS 3 54 4.629e-05 0.0005017
428 BONE DEVELOPMENT 4 156 4.658e-05 0.0005017
429 VENTRICULAR SEPTUM DEVELOPMENT 3 54 4.629e-05 0.0005017
430 CELLULAR RESPONSE TO INORGANIC SUBSTANCE 4 156 4.658e-05 0.0005017
431 PROTEIN LOCALIZATION TO NUCLEUS 4 156 4.658e-05 0.0005017
432 CELL CYCLE PROCESS 8 1081 4.628e-05 0.0005017
433 PROTEIN LOCALIZATION 10 1805 4.803e-05 0.0005162
434 NEGATIVE REGULATION OF MUSCLE CELL DIFFERENTIATION 3 55 4.892e-05 0.0005233
435 REGULATION OF KIDNEY DEVELOPMENT 3 55 4.892e-05 0.0005233
436 SMAD PROTEIN SIGNAL TRANSDUCTION 3 56 5.165e-05 0.0005512
437 REGENERATION 4 161 5.267e-05 0.0005608
438 CELLULAR RESPONSE TO OXYGEN CONTAINING COMPOUND 7 799 5.347e-05 0.000568
439 CHROMATIN MODIFICATION 6 539 5.418e-05 0.0005742
440 REGULATION OF CYTOKINE PRODUCTION INVOLVED IN IMMUNE RESPONSE 3 57 5.447e-05 0.000576
441 CELLULAR RESPONSE TO BIOTIC STIMULUS 4 163 5.527e-05 0.0005831
442 POSITIVE REGULATION OF DNA BIOSYNTHETIC PROCESS 3 59 6.041e-05 0.000636
443 POSITIVE REGULATION OF SMOOTH MUSCLE CELL PROLIFERATION 3 60 6.354e-05 0.0006659
444 POSITIVE REGULATION OF OSTEOBLAST DIFFERENTIATION 3 60 6.354e-05 0.0006659
445 PROTEIN LOCALIZATION TO ORGANELLE 6 556 6.437e-05 0.0006731
446 NEGATIVE REGULATION OF CELL GROWTH 4 170 6.509e-05 0.0006791
447 POSITIVE REGULATION OF PHOSPHATIDYLINOSITOL 3 KINASE SIGNALING 3 62 7.01e-05 0.0007297
448 CELLULAR RESPONSE TO ACID CHEMICAL 4 175 7.284e-05 0.0007549
449 HOMEOSTASIS OF NUMBER OF CELLS 4 175 7.284e-05 0.0007549
450 CELLULAR RESPONSE TO RETINOIC ACID 3 65 8.075e-05 0.0008331
451 REGULATION OF CHEMOKINE PRODUCTION 3 65 8.075e-05 0.0008331
452 NEGATIVE REGULATION OF CELLULAR RESPONSE TO TRANSFORMING GROWTH FACTOR BETA STIMULUS 3 66 8.453e-05 0.0008663
453 FOREBRAIN GENERATION OF NEURONS 3 66 8.453e-05 0.0008663
454 NEGATIVE REGULATION OF TRANSFORMING GROWTH FACTOR BETA RECEPTOR SIGNALING PATHWAY 3 66 8.453e-05 0.0008663
455 RESPONSE TO KETONE 4 182 8.481e-05 0.0008673
456 POSITIVE REGULATION OF NEURON DEATH 3 67 8.841e-05 0.0008937
457 POSITIVE REGULATION OF CELLULAR PROTEIN LOCALIZATION 5 360 8.854e-05 0.0008937
458 REGULATION OF EXTRACELLULAR MATRIX ASSEMBLY 2 11 8.874e-05 0.0008937
459 PROSTATE GLAND GROWTH 2 11 8.874e-05 0.0008937
460 NEURON FATE COMMITMENT 3 67 8.841e-05 0.0008937
461 EPITHELIAL CELL DIFFERENTIATION INVOLVED IN PROSTATE GLAND DEVELOPMENT 2 11 8.874e-05 0.0008937
462 ENDOTHELIAL TUBE MORPHOGENESIS 2 11 8.874e-05 0.0008937
463 RESPONSE TO ACTIVITY 3 69 9.653e-05 0.0009701
464 REGULATION OF NEURON APOPTOTIC PROCESS 4 192 0.0001043 0.001046
465 CELL FATE SPECIFICATION 3 71 0.0001051 0.001052
466 CARTILAGE MORPHOGENESIS 2 12 0.0001064 0.001053
467 REGULATION OF VITAMIN METABOLIC PROCESS 2 12 0.0001064 0.001053
468 REGULATION OF MESENCHYMAL CELL APOPTOTIC PROCESS 2 12 0.0001064 0.001053
469 REGULATION OF THYMOCYTE APOPTOTIC PROCESS 2 12 0.0001064 0.001053
470 POSITIVE REGULATION OF SMAD PROTEIN IMPORT INTO NUCLEUS 2 12 0.0001064 0.001053
471 PANCREAS DEVELOPMENT 3 73 0.0001142 0.001128
472 REGULATION OF STRESS ACTIVATED PROTEIN KINASE SIGNALING CASCADE 4 197 0.0001152 0.001135
473 REGULATION OF INTRACELLULAR PROTEIN TRANSPORT 5 381 0.0001156 0.001137
474 CELLULAR MACROMOLECULE LOCALIZATION 8 1234 0.0001178 0.001157
475 REGULATION OF STEROID METABOLIC PROCESS 3 74 0.0001189 0.001165
476 NEURONAL STEM CELL DIVISION 2 13 0.0001256 0.0012
477 ARTERY DEVELOPMENT 3 75 0.0001238 0.0012
478 CELLULAR RESPONSE TO HEPATOCYTE GROWTH FACTOR STIMULUS 2 13 0.0001256 0.0012
479 CARDIOBLAST DIFFERENTIATION 2 13 0.0001256 0.0012
480 RESPONSE TO HEPATOCYTE GROWTH FACTOR 2 13 0.0001256 0.0012
481 NEUROBLAST DIVISION 2 13 0.0001256 0.0012
482 GLIAL CELL FATE COMMITMENT 2 13 0.0001256 0.0012
483 BIOMINERAL TISSUE DEVELOPMENT 3 75 0.0001238 0.0012
484 ODONTOGENESIS OF DENTIN CONTAINING TOOTH 3 75 0.0001238 0.0012
485 POSITIVE REGULATION OF CARDIAC MUSCLE CELL DIFFERENTIATION 2 13 0.0001256 0.0012
486 REGULATION OF BICELLULAR TIGHT JUNCTION ASSEMBLY 2 13 0.0001256 0.0012
487 NEGATIVE REGULATION OF DNA DAMAGE RESPONSE SIGNAL TRANSDUCTION BY P53 CLASS MEDIATOR 2 13 0.0001256 0.0012
488 POSITIVE REGULATION OF MAP KINASE ACTIVITY 4 207 0.0001394 0.001329
489 REGULATION OF LEUKOCYTE APOPTOTIC PROCESS 3 79 0.0001444 0.001365
490 NEGATIVE REGULATION OF PROTEIN BINDING 3 79 0.0001444 0.001365
491 BONE MORPHOGENESIS 3 79 0.0001444 0.001365
492 POSITIVE REGULATION OF TRANSPORT 7 936 0.0001446 0.001365
493 LYMPHOCYTE DIFFERENTIATION 4 209 0.0001446 0.001365
494 SPECIFICATION OF ORGAN IDENTITY 2 14 0.0001465 0.001369
495 POSITIVE REGULATION OF TRANSCRIPTION REGULATORY REGION DNA BINDING 2 14 0.0001465 0.001369
496 REGULATION OF PROTEIN KINASE C SIGNALING 2 14 0.0001465 0.001369
497 REGULATION OF EXTRACELLULAR MATRIX DISASSEMBLY 2 14 0.0001465 0.001369
498 MIDGUT DEVELOPMENT 2 14 0.0001465 0.001369
499 RESPONSE TO MECHANICAL STIMULUS 4 210 0.0001473 0.001374
500 NEGATIVE REGULATION OF LIPID METABOLIC PROCESS 3 80 0.0001499 0.001393
501 POSITIVE REGULATION OF PROTEIN SECRETION 4 211 0.00015 0.001393
502 REGULATION OF FIBROBLAST PROLIFERATION 3 81 0.0001556 0.001442
503 POSITIVE REGULATION OF HOMEOSTATIC PROCESS 4 216 0.0001641 0.001518
504 OTIC VESICLE DEVELOPMENT 2 15 0.0001689 0.00155
505 MORPHOGENESIS OF AN EPITHELIAL FOLD 2 15 0.0001689 0.00155
506 STRIATED MUSCLE CELL PROLIFERATION 2 15 0.0001689 0.00155
507 POSITIVE REGULATION OF T CELL APOPTOTIC PROCESS 2 15 0.0001689 0.00155
508 CHROMATIN ORGANIZATION 6 663 0.0001693 0.001551
509 POSITIVE REGULATION OF MUSCLE CELL DIFFERENTIATION 3 84 0.0001733 0.001581
510 TISSUE MIGRATION 3 84 0.0001733 0.001581
511 CARDIAC SEPTUM DEVELOPMENT 3 85 0.0001795 0.001631
512 REGULATION OF STRIATED MUSCLE CELL DIFFERENTIATION 3 85 0.0001795 0.001631
513 CELL CYCLE 8 1316 0.0001844 0.001672
514 REGULATION OF SMAD PROTEIN IMPORT INTO NUCLEUS 2 16 0.0001928 0.001739
515 MORPHOGENESIS OF AN ENDOTHELIUM 2 16 0.0001928 0.001739
516 ORGAN INDUCTION 2 16 0.0001928 0.001739
517 POSITIVE REGULATION OF PEPTIDYL SERINE PHOSPHORYLATION 3 88 0.0001989 0.00179
518 NEGATIVE REGULATION OF CELLULAR COMPONENT ORGANIZATION 6 684 0.0002006 0.001802
519 RESPONSE TO DRUG 5 431 0.0002055 0.001843
520 AXIS SPECIFICATION 3 90 0.0002126 0.001891
521 NEGATIVE REGULATION OF INTRINSIC APOPTOTIC SIGNALING PATHWAY 3 90 0.0002126 0.001891
522 MIDBRAIN DEVELOPMENT 3 90 0.0002126 0.001891
523 REGULATION OF CELL MATRIX ADHESION 3 90 0.0002126 0.001891
524 CELLULAR RESPONSE TO LITHIUM ION 2 17 0.0002184 0.001933
525 CELL DEATH 7 1001 0.0002191 0.001933
526 NEGATIVE REGULATION OF INTRACELLULAR SIGNAL TRANSDUCTION 5 437 0.0002191 0.001933
527 ESTABLISHMENT OF TISSUE POLARITY 2 17 0.0002184 0.001933
528 REGULATION OF VASCULATURE DEVELOPMENT 4 233 0.0002194 0.001933
529 INNER EAR MORPHOGENESIS 3 92 0.0002268 0.001995
530 EMBRYONIC SKELETAL SYSTEM MORPHOGENESIS 3 93 0.0002342 0.002056
531 RESPONSE TO BMP 3 94 0.0002417 0.00211
532 REGULATION OF DNA BIOSYNTHETIC PROCESS 3 94 0.0002417 0.00211
533 CELLULAR RESPONSE TO BMP STIMULUS 3 94 0.0002417 0.00211
534 REGULATION OF HORMONE BIOSYNTHETIC PROCESS 2 18 0.0002455 0.002131
535 PERICARDIUM DEVELOPMENT 2 18 0.0002455 0.002131
536 NEPHRON TUBULE FORMATION 2 18 0.0002455 0.002131
537 RESPONSE TO CYTOKINE 6 714 0.0002531 0.002193
538 CARDIOCYTE DIFFERENTIATION 3 96 0.0002572 0.002224
539 MUSCLE CELL PROLIFERATION 2 19 0.0002741 0.002353
540 NEGATIVE REGULATION OF EXTRINSIC APOPTOTIC SIGNALING PATHWAY 3 98 0.0002733 0.002353
541 POSITIVE REGULATION OF CARDIAC MUSCLE CELL PROLIFERATION 2 19 0.0002741 0.002353
542 POSITIVE REGULATION OF CHONDROCYTE DIFFERENTIATION 2 19 0.0002741 0.002353
543 CELL DIVISION 5 460 0.0002778 0.002381
544 MACROMOLECULAR COMPLEX ASSEMBLY 8 1398 0.0002795 0.002391
545 EXTRINSIC APOPTOTIC SIGNALING PATHWAY 3 99 0.0002816 0.002391
546 REGULATION OF TRANSFORMING GROWTH FACTOR BETA RECEPTOR SIGNALING PATHWAY 3 99 0.0002816 0.002391
547 REGULATION OF CELLULAR RESPONSE TO TRANSFORMING GROWTH FACTOR BETA STIMULUS 3 99 0.0002816 0.002391
548 POSITIVE REGULATION OF CELL SUBSTRATE ADHESION 3 99 0.0002816 0.002391
549 REGULATION OF CATABOLIC PROCESS 6 731 0.0002873 0.002435
550 MODIFICATION OF MORPHOLOGY OR PHYSIOLOGY OF OTHER ORGANISM 3 100 0.0002901 0.002449
551 LIMBIC SYSTEM DEVELOPMENT 3 100 0.0002901 0.002449
552 REGULATION OF TRANSPORT 9 1804 0.0002926 0.002467
553 REGULATION OF NEURON DEATH 4 252 0.0002958 0.002489
554 REGULATION OF PRODUCTION OF MOLECULAR MEDIATOR OF IMMUNE RESPONSE 3 101 0.0002987 0.002509
555 POSITIVE REGULATION OF LYMPHOCYTE APOPTOTIC PROCESS 2 20 0.0003044 0.002529
556 NEGATIVE REGULATION OF BIOMINERAL TISSUE DEVELOPMENT 2 20 0.0003044 0.002529
557 REGULATION OF SMOOTH MUSCLE CELL DIFFERENTIATION 2 20 0.0003044 0.002529
558 TONGUE DEVELOPMENT 2 20 0.0003044 0.002529
559 BRANCHING INVOLVED IN MAMMARY GLAND DUCT MORPHOGENESIS 2 20 0.0003044 0.002529
560 MYELOID DENDRITIC CELL DIFFERENTIATION 2 20 0.0003044 0.002529
561 WOUND HEALING 5 470 0.0003068 0.002545
562 POSITIVE REGULATION OF INTRACELLULAR PROTEIN TRANSPORT 4 258 0.0003234 0.002678
563 POSITIVE REGULATION OF PROTEIN IMPORT 3 104 0.0003255 0.00269
564 POSITIVE REGULATION OF NEUROBLAST PROLIFERATION 2 21 0.0003361 0.002734
565 LEFT RIGHT PATTERN FORMATION 2 21 0.0003361 0.002734
566 ECTODERM DEVELOPMENT 2 21 0.0003361 0.002734
567 CEREBRAL CORTEX DEVELOPMENT 3 105 0.0003348 0.002734
568 CELL AGGREGATION 2 21 0.0003361 0.002734
569 POSITIVE REGULATION OF ADHERENS JUNCTION ORGANIZATION 2 21 0.0003361 0.002734
570 COCHLEA MORPHOGENESIS 2 21 0.0003361 0.002734
571 NEGATIVE REGULATION OF NEURAL PRECURSOR CELL PROLIFERATION 2 21 0.0003361 0.002734
572 CARTILAGE CONDENSATION 2 21 0.0003361 0.002734
573 REGULATION OF CYTOPLASMIC TRANSPORT 5 481 0.0003413 0.002771
574 FAT CELL DIFFERENTIATION 3 106 0.0003443 0.002791
575 NEGATIVE REGULATION OF LOCOMOTION 4 263 0.0003479 0.002815
576 CELLULAR RESPONSE TO EXTERNAL STIMULUS 4 264 0.0003529 0.002849
577 RESPONSE TO RETINOIC ACID 3 107 0.0003539 0.002849
578 PLATELET DEGRANULATION 3 107 0.0003539 0.002849
579 NEGATIVE REGULATION OF CYTOKINE PRODUCTION INVOLVED IN IMMUNE RESPONSE 2 22 0.0003694 0.002949
580 BETA CATENIN DESTRUCTION COMPLEX DISASSEMBLY 2 22 0.0003694 0.002949
581 MODULATION OF TRANSCRIPTION IN OTHER ORGANISM INVOLVED IN SYMBIOTIC INTERACTION 2 22 0.0003694 0.002949
582 PROTEIN LOCALIZATION TO CELL SURFACE 2 22 0.0003694 0.002949
583 POSITIVE REGULATION OF MESONEPHROS DEVELOPMENT 2 22 0.0003694 0.002949
584 NEGATIVE REGULATION OF DNA METABOLIC PROCESS 3 111 0.0003941 0.00314
585 REGULATION OF CELL DIVISION 4 272 0.0003952 0.003143
586 PROSTATE GLAND MORPHOGENESIS 2 23 0.0004043 0.003197
587 POSITIVE REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER IN RESPONSE TO STRESS 2 23 0.0004043 0.003197
588 REGULATION OF OSTEOBLAST PROLIFERATION 2 23 0.0004043 0.003197
589 EAR MORPHOGENESIS 3 112 0.0004046 0.003197
590 REGULATION OF EMBRYONIC DEVELOPMENT 3 114 0.0004262 0.003361
591 REGULATION OF CHROMOSOME ORGANIZATION 4 278 0.0004291 0.003378
592 EMBRYONIC CAMERA TYPE EYE MORPHOGENESIS 2 24 0.0004407 0.003441
593 RESPONSE TO STEROL 2 24 0.0004407 0.003441
594 POSITIVE REGULATION OF CELL JUNCTION ASSEMBLY 2 24 0.0004407 0.003441
595 NEGATIVE REGULATION OF MYOBLAST DIFFERENTIATION 2 24 0.0004407 0.003441
596 REGULATION OF ODONTOGENESIS 2 24 0.0004407 0.003441
597 RESPONSE TO FIBROBLAST GROWTH FACTOR 3 116 0.0004484 0.003495
598 POSITIVE REGULATION OF CYTOPLASMIC TRANSPORT 4 282 0.0004529 0.003518
599 REGULATION OF LIPID METABOLIC PROCESS 4 282 0.0004529 0.003518
600 NEGATIVE REGULATION OF CYTOPLASMIC TRANSPORT 3 117 0.0004598 0.003566
601 PROTEIN COMPLEX BIOGENESIS 7 1132 0.0004642 0.003588
602 PROTEIN COMPLEX ASSEMBLY 7 1132 0.0004642 0.003588
603 CELLULAR RESPONSE TO EPIDERMAL GROWTH FACTOR STIMULUS 2 25 0.0004786 0.003693
604 REGULATION OF DEVELOPMENTAL GROWTH 4 289 0.0004968 0.003814
605 CYTOKINE PRODUCTION 3 120 0.0004952 0.003814
606 POSITIVE REGULATION OF PROTEIN SERINE THREONINE KINASE ACTIVITY 4 289 0.0004968 0.003814
607 HEART TRABECULA MORPHOGENESIS 2 26 0.0005181 0.003914
608 LEUKOCYTE DIFFERENTIATION 4 292 0.0005164 0.003914
609 REGULATION OF MESONEPHROS DEVELOPMENT 2 26 0.0005181 0.003914
610 MESODERMAL CELL DIFFERENTIATION 2 26 0.0005181 0.003914
611 HEART GROWTH 2 26 0.0005181 0.003914
612 REGULATION OF HORMONE METABOLIC PROCESS 2 26 0.0005181 0.003914
613 REGULATION OF P38MAPK CASCADE 2 26 0.0005181 0.003914
614 MYELOID DENDRITIC CELL ACTIVATION 2 26 0.0005181 0.003914
615 POSITIVE REGULATION OF VASCULAR ENDOTHELIAL GROWTH FACTOR PRODUCTION 2 26 0.0005181 0.003914
616 REGULATION OF CELL FATE COMMITMENT 2 26 0.0005181 0.003914
617 REGULATION OF EPITHELIAL CELL DIFFERENTIATION 3 122 0.0005197 0.003919
618 T CELL DIFFERENTIATION 3 123 0.0005322 0.004007
619 POSITIVE REGULATION OF HEART GROWTH 2 27 0.0005591 0.004183
620 NEGATIVE REGULATION OF INTRINSIC APOPTOTIC SIGNALING PATHWAY IN RESPONSE TO DNA DAMAGE 2 27 0.0005591 0.004183
621 NEGATIVE REGULATION OF SIGNAL TRANSDUCTION BY P53 CLASS MEDIATOR 2 27 0.0005591 0.004183
622 SUBSTRATE DEPENDENT CELL MIGRATION 2 27 0.0005591 0.004183
623 POSITIVE REGULATION OF CELL PROJECTION ORGANIZATION 4 303 0.0005934 0.004432
624 POSITIVE REGULATION OF LEUKOCYTE APOPTOTIC PROCESS 2 28 0.0006016 0.004451
625 GASTRULATION WITH MOUTH FORMING SECOND 2 28 0.0006016 0.004451
626 REGULATION OF DNA DAMAGE RESPONSE SIGNAL TRANSDUCTION BY P53 CLASS MEDIATOR 2 28 0.0006016 0.004451
627 REGULATION OF LIPID BIOSYNTHETIC PROCESS 3 128 0.0005978 0.004451
628 MORPHOGENESIS OF A POLARIZED EPITHELIUM 2 28 0.0006016 0.004451
629 METANEPHROS MORPHOGENESIS 2 28 0.0006016 0.004451
630 PEPTIDYL AMINO ACID MODIFICATION 6 841 0.0006068 0.004482
631 NUCLEAR IMPORT 3 129 0.0006115 0.004502
632 CELL JUNCTION ASSEMBLY 3 129 0.0006115 0.004502
633 POSITIVE REGULATION OF NEURON DIFFERENTIATION 4 306 0.0006158 0.004526
634 INTRACELLULAR SIGNAL TRANSDUCTION 8 1572 0.0006184 0.004539
635 NEGATIVE REGULATION OF PRODUCTION OF MOLECULAR MEDIATOR OF IMMUNE RESPONSE 2 29 0.0006457 0.004716
636 REGULATION OF CARDIAC MUSCLE CELL PROLIFERATION 2 29 0.0006457 0.004716
637 NEUROBLAST PROLIFERATION 2 29 0.0006457 0.004716
638 REGULATION OF NEURON DIFFERENTIATION 5 554 0.0006503 0.004743
639 MAINTENANCE OF CELL NUMBER 3 132 0.0006538 0.004761
640 POSITIVE REGULATION OF VASCULATURE DEVELOPMENT 3 133 0.0006683 0.004859
641 REGULATION OF HEMOPOIESIS 4 314 0.0006783 0.004924
642 PROTEIN EXPORT FROM NUCLEUS 2 30 0.0006913 0.004979
643 PROTEIN LOCALIZATION TO CYTOSKELETON 2 30 0.0006913 0.004979
644 ESTABLISHMENT OR MAINTENANCE OF EPITHELIAL CELL APICAL BASAL POLARITY 2 30 0.0006913 0.004979
645 SMOOTH MUSCLE CELL DIFFERENTIATION 2 30 0.0006913 0.004979
646 RESPONSE TO EPIDERMAL GROWTH FACTOR 2 30 0.0006913 0.004979
647 NEGATIVE REGULATION OF CELLULAR PROTEIN LOCALIZATION 3 135 0.000698 0.005012
648 POSITIVE REGULATION OF STRESS ACTIVATED PROTEIN KINASE SIGNALING CASCADE 3 135 0.000698 0.005012
649 RESPONSE TO WOUNDING 5 563 0.0006995 0.005015
650 CELL ACTIVATION 5 568 0.000728 0.005206
651 ACTIVATION OF MAPK ACTIVITY 3 137 0.0007284 0.005206
652 HYALURONAN METABOLIC PROCESS 2 31 0.0007383 0.005261
653 REGULATION OF VASCULAR ENDOTHELIAL GROWTH FACTOR PRODUCTION 2 31 0.0007383 0.005261
654 PATTERNING OF BLOOD VESSELS 2 32 0.0007869 0.005582
655 REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER IN RESPONSE TO HYPOXIA 2 32 0.0007869 0.005582
656 BLOOD VESSEL REMODELING 2 32 0.0007869 0.005582
657 ESTABLISHMENT OR MAINTENANCE OF CELL POLARITY 3 141 0.0007919 0.005608
658 RESPONSE TO BIOTIC STIMULUS 6 886 0.0007983 0.005645
659 EPIDERMAL CELL DIFFERENTIATION 3 142 0.0008083 0.005707
660 MULTI ORGANISM REPRODUCTIVE PROCESS 6 891 0.0008221 0.005796
661 NEGATIVE REGULATION OF INTRACELLULAR TRANSPORT 3 143 0.0008249 0.005807
662 DENDRITIC CELL DIFFERENTIATION 2 33 0.000837 0.005857
663 REGULATION OF MYELINATION 2 33 0.000837 0.005857
664 POSITIVE REGULATION OF RESPONSE TO CYTOKINE STIMULUS 2 33 0.000837 0.005857
665 EMBRYONIC EYE MORPHOGENESIS 2 33 0.000837 0.005857
666 SECRETION 5 588 0.0008509 0.005945
667 REGULATION OF INTRINSIC APOPTOTIC SIGNALING PATHWAY 3 145 0.0008587 0.005991
668 FOREBRAIN NEURON DEVELOPMENT 2 34 0.0008886 0.006162
669 LUNG EPITHELIUM DEVELOPMENT 2 34 0.0008886 0.006162
670 PROTEIN KINASE B SIGNALING 2 34 0.0008886 0.006162
671 REGULATION OF INTRINSIC APOPTOTIC SIGNALING PATHWAY IN RESPONSE TO DNA DAMAGE 2 34 0.0008886 0.006162
672 POSITIVE REGULATION OF HYDROLASE ACTIVITY 6 905 0.000892 0.006176
673 PEPTIDYL SERINE MODIFICATION 3 148 0.0009112 0.0063
674 LYMPHOCYTE ACTIVATION 4 342 0.0009328 0.006439
675 NEGATIVE REGULATION OF RESPONSE TO OXIDATIVE STRESS 2 35 0.0009417 0.006454
676 BONE REMODELING 2 35 0.0009417 0.006454
677 HAIR CELL DIFFERENTIATION 2 35 0.0009417 0.006454
678 NEGATIVE REGULATION OF CELLULAR RESPONSE TO OXIDATIVE STRESS 2 35 0.0009417 0.006454
679 EMBRYONIC CAMERA TYPE EYE DEVELOPMENT 2 35 0.0009417 0.006454
680 CHROMATIN REMODELING 3 150 0.0009473 0.006482
681 CELLULAR RESPONSE TO CYTOKINE STIMULUS 5 606 0.0009742 0.006657
682 POSITIVE REGULATION OF PROTEIN ACETYLATION 2 36 0.0009963 0.006788
683 POSITIVE CHEMOTAXIS 2 36 0.0009963 0.006788
684 CELL CYCLE ARREST 3 154 0.001022 0.006953
685 PROTEIN IMPORT 3 155 0.001041 0.007074
686 MYOBLAST DIFFERENTIATION 2 37 0.001052 0.007097
687 GLIAL CELL MIGRATION 2 37 0.001052 0.007097
688 ESTABLISHMENT OR MAINTENANCE OF APICAL BASAL CELL POLARITY 2 37 0.001052 0.007097
689 ESTABLISHMENT OR MAINTENANCE OF BIPOLAR CELL POLARITY 2 37 0.001052 0.007097
690 NEGATIVE REGULATION OF PROTEIN MODIFICATION PROCESS 5 616 0.001048 0.007097
691 POSITIVE REGULATION OF DEVELOPMENTAL GROWTH 3 156 0.001061 0.007144
692 NUCLEAR TRANSPORT 4 355 0.001071 0.007203
693 REGULATION OF INTRACELLULAR TRANSPORT 5 621 0.001087 0.007298
694 REGULATION OF DEPHOSPHORYLATION 3 158 0.001101 0.007379
695 POSITIVE REGULATION OF BIOMINERAL TISSUE DEVELOPMENT 2 38 0.00111 0.007421
696 POSITIVE REGULATION OF ORGAN GROWTH 2 38 0.00111 0.007421
697 TRABECULA MORPHOGENESIS 2 39 0.001169 0.007782
698 REGULATION OF CELL ADHESION MEDIATED BY INTEGRIN 2 39 0.001169 0.007782
699 COCHLEA DEVELOPMENT 2 39 0.001169 0.007782
700 CELL CHEMOTAXIS 3 162 0.001183 0.007862
701 POSITIVE REGULATION OF HEMOPOIESIS 3 163 0.001204 0.007991
702 CELL MORPHOGENESIS INVOLVED IN NEURON DIFFERENTIATION 4 368 0.001224 0.00811
703 ENDOCRINE PANCREAS DEVELOPMENT 2 40 0.00123 0.008127
704 ENDODERMAL CELL DIFFERENTIATION 2 40 0.00123 0.008127
705 POSITIVE REGULATION OF INTRACELLULAR TRANSPORT 4 370 0.001248 0.008227
706 POSITIVE REGULATION OF SECRETION 4 370 0.001248 0.008227
707 CENTRAL NERVOUS SYSTEM NEURON DIFFERENTIATION 3 166 0.001269 0.00835
708 NEGATIVE REGULATION OF IMMUNE SYSTEM PROCESS 4 372 0.001273 0.008369
709 NEGATIVE REGULATION OF FAT CELL DIFFERENTIATION 2 41 0.001292 0.008453
710 POSITIVE REGULATION OF KIDNEY DEVELOPMENT 2 41 0.001292 0.008453
711 LUNG ALVEOLUS DEVELOPMENT 2 41 0.001292 0.008453
712 POSITIVE REGULATION OF DNA BINDING 2 42 0.001355 0.008831
713 POSITIVE REGULATION OF NEURAL PRECURSOR CELL PROLIFERATION 2 42 0.001355 0.008831
714 REGULATION OF HEART GROWTH 2 42 0.001355 0.008831
715 POSITIVE REGULATION OF APOPTOTIC SIGNALING PATHWAY 3 171 0.001382 0.008992
716 REGULATION OF CARBOHYDRATE METABOLIC PROCESS 3 172 0.001405 0.009118
717 REGULATION OF CELL SIZE 3 172 0.001405 0.009118
718 REGULATION OF POLYSACCHARIDE METABOLIC PROCESS 2 43 0.00142 0.00919
719 BETA CATENIN TCF COMPLEX ASSEMBLY 2 43 0.00142 0.00919
720 STRIATED MUSCLE CELL DIFFERENTIATION 3 173 0.001429 0.009219
721 REGULATION OF CELL SUBSTRATE ADHESION 3 173 0.001429 0.009219
722 RESPONSE TO CORTICOSTEROID 3 176 0.001501 0.00966
723 REGULATION OF PROTEIN SECRETION 4 389 0.001501 0.00966
724 SPROUTING ANGIOGENESIS 2 45 0.001554 0.009976
725 REGULATION OF GTPASE ACTIVITY 5 673 0.001554 0.009976
726 REGULATION OF PROTEIN CATABOLIC PROCESS 4 393 0.001559 0.009989
NumGOOverlapSizeP ValueAdj. P Value
1 NUCLEIC ACID BINDING TRANSCRIPTION FACTOR ACTIVITY 12 1199 8.989e-09 4.176e-06
2 TRANSFORMING GROWTH FACTOR BETA RECEPTOR BINDING 5 50 5.027e-09 4.176e-06
3 SMAD BINDING 5 72 3.256e-08 9.669e-06
4 CHROMATIN BINDING 8 435 5.204e-08 9.669e-06
5 MACROMOLECULAR COMPLEX BINDING 12 1399 5.032e-08 9.669e-06
6 TRANSCRIPTION FACTOR ACTIVITY RNA POLYMERASE II DISTAL ENHANCER SEQUENCE SPECIFIC BINDING 5 90 1.007e-07 1.336e-05
7 RECEPTOR BINDING 12 1476 9.1e-08 1.336e-05
8 TRANSCRIPTION FACTOR ACTIVITY RNA POLYMERASE II CORE PROMOTER PROXIMAL REGION SEQUENCE SPECIFIC BINDING 7 328 1.506e-07 1.749e-05
9 TRANSCRIPTION FACTOR BINDING 8 524 2.17e-07 2.24e-05
10 SEQUENCE SPECIFIC DNA BINDING 10 1037 3.337e-07 3.1e-05
11 REGULATORY REGION NUCLEIC ACID BINDING 9 818 5.114e-07 4.319e-05
12 RNA POLYMERASE II TRANSCRIPTION FACTOR ACTIVITY SEQUENCE SPECIFIC DNA BINDING 8 629 8.663e-07 6.706e-05
13 PROTEIN KINASE ACTIVITY 8 640 9.87e-07 7.053e-05
14 TRANSCRIPTIONAL ACTIVATOR ACTIVITY RNA POLYMERASE II TRANSCRIPTION REGULATORY REGION SEQUENCE SPECIFIC BINDING 6 315 2.569e-06 0.0001705
15 KINASE ACTIVITY 8 842 7.584e-06 0.0004697
16 KINASE BINDING 7 606 9.018e-06 0.0005221
17 TRANSCRIPTIONAL ACTIVATOR ACTIVITY RNA POLYMERASE II CORE PROMOTER PROXIMAL REGION SEQUENCE SPECIFIC BINDING 5 226 9.553e-06 0.0005221
18 PROTEIN HETERODIMERIZATION ACTIVITY 6 468 2.459e-05 0.001161
19 CYTOKINE RECEPTOR BINDING 5 271 2.294e-05 0.001161
20 TRANSFERASE ACTIVITY TRANSFERRING PHOSPHORUS CONTAINING GROUPS 8 992 2.5e-05 0.001161
21 ENZYME BINDING 10 1737 3.447e-05 0.001525
22 DOUBLE STRANDED DNA BINDING 7 764 4.021e-05 0.001698
23 GROWTH FACTOR ACTIVITY 4 160 5.141e-05 0.002077
24 I SMAD BINDING 2 11 8.874e-05 0.003435
25 PROTEIN DOMAIN SPECIFIC BINDING 6 624 0.0001216 0.004519
26 BETA CATENIN BINDING 3 84 0.0001733 0.005193
27 TRANSMEMBRANE RECEPTOR PROTEIN KINASE ACTIVITY 3 81 0.0001556 0.005193
28 C2H2 ZINC FINGER DOMAIN BINDING 2 14 0.0001465 0.005193
29 PROTEIN KINASE A CATALYTIC SUBUNIT BINDING 2 15 0.0001689 0.005193
30 OXIDOREDUCTASE ACTIVITY ACTING ON THE CH NH2 GROUP OF DONORS OXYGEN AS ACCEPTOR 2 15 0.0001689 0.005193
31 CYTOKINE ACTIVITY 4 219 0.0001731 0.005193
32 TRANSFORMING GROWTH FACTOR BETA BINDING 2 16 0.0001928 0.005598
33 TRANSMEMBRANE RECEPTOR PROTEIN SERINE THREONINE KINASE ACTIVITY 2 17 0.0002184 0.006148
34 PROTEIN SERINE THREONINE KINASE ACTIVITY 5 445 0.0002384 0.006513
35 OXIDOREDUCTASE ACTIVITY ACTING ON THE CH NH2 GROUP OF DONORS 2 19 0.0002741 0.007276
36 DNA BINDING BENDING 2 20 0.0003044 0.007854
37 RNA POLYMERASE II TRANSCRIPTION FACTOR BINDING 3 104 0.0003255 0.008174
38 TRANSCRIPTIONAL REPRESSOR ACTIVITY RNA POLYMERASE II CORE PROMOTER PROXIMAL REGION SEQUENCE SPECIFIC BINDING 3 105 0.0003348 0.008186
39 IONOTROPIC GLUTAMATE RECEPTOR BINDING 2 23 0.0004043 0.00939
40 FIBROBLAST GROWTH FACTOR BINDING 2 23 0.0004043 0.00939
NumGOOverlapSizeP ValueAdj. P Value
1 TRANSCRIPTION FACTOR COMPLEX 8 298 2.738e-09 1.599e-06
2 NUCLEAR TRANSCRIPTION FACTOR COMPLEX 6 127 1.208e-08 3.526e-06
3 RNA POLYMERASE II TRANSCRIPTION FACTOR COMPLEX 5 101 1.797e-07 3.498e-05
4 EXTRACELLULAR MATRIX 7 426 8.777e-07 0.0001281
5 EXTRACELLULAR SPACE 9 1376 3.598e-05 0.004202
6 PLATELET ALPHA GRANULE LUMEN 3 55 4.892e-05 0.004762
7 PROTEINACEOUS EXTRACELLULAR MATRIX 5 356 8.4e-05 0.006478
8 WNT SIGNALOSOME 2 11 8.874e-05 0.006478
9 PLATELET ALPHA GRANULE 3 75 0.0001238 0.008031
10 BETA CATENIN DESTRUCTION COMPLEX 2 14 0.0001465 0.008554
11 SECRETORY GRANULE LUMEN 3 85 0.0001795 0.009529

Over-represented Pathway

NumPathwayPathviewOverlapSizeP ValueAdj. P Value
1 hsa04390_Hippo_signaling_pathway 10 154 2.605e-15 4.69e-13
2 hsa04520_Adherens_junction 5 73 3.493e-08 3.143e-06
3 hsa04916_Melanogenesis 5 101 1.797e-07 1.078e-05
4 hsa04340_Hedgehog_signaling_pathway 4 56 7.87e-07 3.542e-05
5 hsa04310_Wnt_signaling_pathway 5 151 1.329e-06 4.783e-05
6 hsa04350_TGF.beta_signaling_pathway 4 85 4.229e-06 0.0001269
7 hsa04144_Endocytosis 4 203 0.0001293 0.003325
8 hsa04010_MAPK_signaling_pathway 4 268 0.0003736 0.008406
9 hsa04110_Cell_cycle 3 128 0.0005978 0.01076
10 hsa04380_Osteoclast_differentiation 3 128 0.0005978 0.01076
11 hsa04510_Focal_adhesion 3 200 0.002162 0.03537
12 hsa04151_PI3K_AKT_signaling_pathway 3 351 0.01033 0.155
13 hsa04014_Ras_signaling_pathway 2 236 0.03742 0.5181

lncRNA-mediated sponge

(Download full result)

Num lncRNA miRNAs           miRNAs count     Gene Sponge regulatory network lncRNA log2FC lncRNA pvalue Gene log2FC Gene pvalue lncRNA-gene Pearson correlation
1

CECR7

 hsa-miR-148b-3p;hsa-miR-182-5p;hsa-miR-200b-3p;hsa-miR-200c-3p;hsa-miR-335-3p;hsa-miR-33a-3p;hsa-miR-375;hsa-miR-429;hsa-miR-532-5p;hsa-miR-590-3p 10 SNAI2 Sponge network 0.551 0.56177 0.205 0.75191 0.482
2

CECR7

 hsa-let-7a-3p;hsa-let-7f-1-3p;hsa-miR-141-3p;hsa-miR-200a-3p;hsa-miR-26b-5p;hsa-miR-29a-5p;hsa-miR-30b-5p;hsa-miR-30c-5p;hsa-miR-335-3p;hsa-miR-33a-3p;hsa-miR-429;hsa-miR-582-5p;hsa-miR-590-3p;hsa-miR-590-5p;hsa-miR-651-5p;hsa-miR-7-1-3p 16 HGF Sponge network 0.551 0.56177 -0.215 0.64343 0.452
3

EMX2OS

 hsa-let-7a-3p;hsa-miR-130b-3p;hsa-miR-141-3p;hsa-miR-148a-3p;hsa-miR-148b-3p;hsa-miR-186-5p;hsa-miR-200a-3p;hsa-miR-29a-3p;hsa-miR-29b-3p;hsa-miR-301a-3p;hsa-miR-32-3p;hsa-miR-324-5p;hsa-miR-331-5p;hsa-miR-335-3p;hsa-miR-335-5p;hsa-miR-33a-3p;hsa-miR-362-3p;hsa-miR-374b-5p;hsa-miR-375;hsa-miR-454-3p;hsa-miR-589-3p;hsa-miR-590-3p;hsa-miR-7-5p 23 TGFB2 Sponge network 1.057 0.31716 0.567 0.30298 0.36
4

EMX2OS

 hsa-let-7a-3p;hsa-let-7f-1-3p;hsa-miR-141-3p;hsa-miR-200a-3p;hsa-miR-26b-5p;hsa-miR-29a-5p;hsa-miR-335-3p;hsa-miR-33a-3p;hsa-miR-421;hsa-miR-590-3p;hsa-miR-7-1-3p 11 HGF Sponge network 1.057 0.31716 -0.215 0.64343 0.353
5

EMX2OS

 hsa-let-7d-5p;hsa-let-7g-5p;hsa-miR-128-3p;hsa-miR-130b-3p;hsa-miR-144-3p;hsa-miR-16-2-3p;hsa-miR-186-5p;hsa-miR-200b-3p;hsa-miR-27a-3p;hsa-miR-32-3p;hsa-miR-331-3p;hsa-miR-339-5p;hsa-miR-374b-5p;hsa-miR-452-3p;hsa-miR-454-3p;hsa-miR-576-5p;hsa-miR-577;hsa-miR-589-3p;hsa-miR-590-3p;hsa-miR-7-1-3p 20 TGFBR1 Sponge network 1.057 0.31716 0.001 0.99924 0.345
6

CECR7

 hsa-miR-130b-3p;hsa-miR-182-5p;hsa-miR-19a-3p;hsa-miR-19b-3p;hsa-miR-200b-3p;hsa-miR-200c-3p;hsa-miR-26b-5p;hsa-miR-301a-3p;hsa-miR-429;hsa-miR-454-3p;hsa-miR-590-3p 11 FOXF2 Sponge network 0.551 0.56177 0.301 0.59948 0.296
7

CECR7

 hsa-let-7a-3p;hsa-let-7f-1-3p;hsa-miR-148b-5p;hsa-miR-186-5p;hsa-miR-192-5p;hsa-miR-221-3p;hsa-miR-222-3p;hsa-miR-29a-3p;hsa-miR-29b-3p;hsa-miR-30b-5p;hsa-miR-30c-5p;hsa-miR-32-3p;hsa-miR-33a-3p;hsa-miR-429;hsa-miR-590-3p;hsa-miR-7-1-3p 16 LIMS1 Sponge network 0.551 0.56177 -0.28 0.76944 0.292
8

MEG3

 hsa-miR-130b-3p;hsa-miR-141-3p;hsa-miR-148a-3p;hsa-miR-148b-3p;hsa-miR-186-5p;hsa-miR-200a-3p;hsa-miR-29a-3p;hsa-miR-29b-3p;hsa-miR-335-3p;hsa-miR-335-5p;hsa-miR-429;hsa-miR-590-5p 12 TGFB2 Sponge network 0.433 0.33816 0.567 0.30298 0.282
9

CECR7

 hsa-let-7a-3p;hsa-miR-130b-3p;hsa-miR-141-3p;hsa-miR-148a-3p;hsa-miR-148b-3p;hsa-miR-186-5p;hsa-miR-200a-3p;hsa-miR-29a-3p;hsa-miR-29b-3p;hsa-miR-301a-3p;hsa-miR-32-3p;hsa-miR-331-5p;hsa-miR-335-3p;hsa-miR-335-5p;hsa-miR-33a-3p;hsa-miR-362-3p;hsa-miR-362-5p;hsa-miR-375;hsa-miR-429;hsa-miR-454-3p;hsa-miR-589-3p;hsa-miR-590-3p;hsa-miR-590-5p 23 TGFB2 Sponge network 0.551 0.56177 0.567 0.30298 0.267

Quest ID: accd5747583adf7752cd592cf3c944b7