This regulatory network was inferred from the input dataset. The miRNAs and mRNAs are
presented as round and rectangle nodes respectively. The numerical value popped up upon mouse over the gene node is the log2 transformed fold-change of the gene expression between the two groups. All of the nodes are clickable, and the detailed information of the miRNAs/mRNAs and related cancer pathway will be displayed in another window. The edges between nodes are supported by both interactions (predicted or experimentally verified) and correlations learnt from cancer dataset. The numerical value popped up upon mouse over the edge is the correlation beat value (effect size) between the two nodes. The experimental evidences of the edges reported in previous cancer studies are highlighted by red/orange color. All of these information can be accessed by the "mouse-over" action. This network shows a full map of the miRNA-mRNA regulation of the input gene list(s), and the hub miRNAs (with the high network degree/betweenness centrality) would be the potential cancer drivers or tumor suppressors. The full result table can be accessed in the "Regulations" tab.
"miRNACancerMAP" is also a network visualization tool for users to draw their regulatory network by personal customization. Users can set the complexity of the network by limiting the number of nodes or edges. And the color of the nodes can be defined by different categories of the mRNAs and miRNAs, such as Gene-Ontology, pathway, and expression status. Users can also select to use network degree or network betweenness centrality to define the node size. And edges can be black or colored by the correlation. Purple edge means negative correlation (mostly found between miRNA and mRNA), and blue edge means positive correlation (found in PPI or miRNA-miRNA sponge effect). We can also add the protein-protein interactions (PPI) into the network. This result will show the cluster of genes regulated by some specific miRNAs. Additionally, miRNA-miRNA edges can be added by the "miRNA sponge" button, presenting some clusters of miRNAs that have the interactions via sponge effect.
Num | microRNA | Gene | miRNA log2FC | miRNA pvalue | Gene log2FC | Gene pvalue | Interaction | Correlation beta | Correlation P-value | PMID | Reported in cancer studies |
---|---|---|---|---|---|---|---|---|---|---|---|
1 | hsa-miR-877-5p | ABHD2 | -1.17 | 0.04417 | 0.63 | 0.15716 | mirMAP | -0.14 | 0.01678 | NA | |
2 | hsa-miR-146a-5p | ADCY1 | -1.12 | 0.05777 | -0.03 | 0.96543 | mirMAP | -0.39 | 8.0E-5 | NA | |
3 | hsa-miR-320a | AOX1 | -0.53 | 0.10886 | -0.25 | 0.79739 | miRanda | -0.48 | 0.03055 | NA | |
4 | hsa-miR-320b | AOX1 | -0.27 | 0.55127 | -0.25 | 0.79739 | miRanda | -0.37 | 0.01876 | NA | |
5 | hsa-miR-877-5p | AR | -1.17 | 0.04417 | -0.52 | 0.55352 | MirTarget | -0.35 | 0.00199 | NA | |
6 | hsa-miR-877-5p | ARHGEF6 | -1.17 | 0.04417 | -1.34 | 0.00865 | miRNAWalker2 validate | -0.14 | 0.0328 | NA | |
7 | hsa-miR-17-5p | BAMBI | -0.67 | 0.04231 | -0.1 | 0.82034 | MirTarget; TargetScan; miRNATAP | -0.3 | 0.00417 | NA | |
8 | hsa-miR-20a-5p | BAMBI | -0.39 | 0.26959 | -0.1 | 0.82034 | miRTarBase; MirTarget; miRNATAP | -0.29 | 0.00196 | NA | |
9 | hsa-miR-877-5p | C1orf21 | -1.17 | 0.04417 | 0.33 | 0.36678 | mirMAP | -0.17 | 0.00023 | NA | |
10 | hsa-let-7g-5p | CASK | -0.81 | 0.01579 | 0.4 | 0.14092 | miRNATAP | -0.15 | 0.01012 | NA | |
11 | hsa-miR-101-5p | CASK | -0.7 | 0.03679 | 0.4 | 0.14092 | MirTarget | -0.21 | 0.00036 | NA | |
12 | hsa-miR-10b-5p | CASK | -1.16 | 0.0029 | 0.4 | 0.14092 | miRNATAP | -0.17 | 0.00068 | NA | |
13 | hsa-miR-126-5p | CASK | -1.4 | 0.0002 | 0.4 | 0.14092 | MirTarget; miRNATAP | -0.25 | 0 | NA | |
14 | hsa-miR-139-5p | CASK | -1.64 | 0.00654 | 0.4 | 0.14092 | mirMAP | -0.11 | 0.00057 | NA | |
15 | hsa-miR-140-5p | CASK | -1.2 | 4.0E-5 | 0.4 | 0.14092 | miRNATAP | -0.25 | 0.0002 | NA | |
16 | hsa-miR-15a-5p | CASK | -0.74 | 0.01074 | 0.4 | 0.14092 | MirTarget; miRNATAP | -0.17 | 0.01733 | NA | |
17 | hsa-miR-16-5p | CASK | -1.02 | 0.00033 | 0.4 | 0.14092 | miRNAWalker2 validate; MirTarget; miRNATAP | -0.16 | 0.02112 | NA | |
18 | hsa-miR-195-5p | CASK | -0.69 | 0.07175 | 0.4 | 0.14092 | MirTarget; miRNATAP | -0.17 | 0.001 | NA | |
19 | hsa-miR-19b-3p | CASK | -1.39 | 0.00103 | 0.4 | 0.14092 | mirMAP | -0.11 | 0.01998 | NA | |
20 | hsa-miR-20a-3p | CASK | -1.06 | 0.01854 | 0.4 | 0.14092 | mirMAP | -0.1 | 0.02043 | NA | |
21 | hsa-miR-29b-2-5p | CASK | -0.62 | 0.10009 | 0.4 | 0.14092 | MirTarget | -0.15 | 0.00612 | NA | |
22 | hsa-miR-3065-5p | CASK | 0.74 | 0.29684 | 0.4 | 0.14092 | mirMAP; miRNATAP | -0.1 | 0.00026 | NA | |
23 | hsa-miR-32-5p | CASK | -1.17 | 0.00457 | 0.4 | 0.14092 | miRNATAP | -0.15 | 0.00203 | NA | |
24 | hsa-miR-339-5p | CASK | -0.92 | 0.04335 | 0.4 | 0.14092 | miRNATAP | -0.12 | 0.00466 | NA | |
25 | hsa-miR-340-5p | CASK | -0.87 | 0.0362 | 0.4 | 0.14092 | mirMAP | -0.19 | 6.0E-5 | NA | |
26 | hsa-miR-369-3p | CASK | -0.83 | 0.17364 | 0.4 | 0.14092 | MirTarget; PITA; miRNATAP | -0.11 | 0.00066 | NA | |
27 | hsa-miR-497-5p | CASK | -0.81 | 0.02071 | 0.4 | 0.14092 | MirTarget; miRNATAP | -0.12 | 0.03685 | NA | |
28 | hsa-miR-628-5p | CASK | -0.85 | 0.02411 | 0.4 | 0.14092 | MirTarget; PITA; miRNATAP | -0.13 | 0.01516 | NA | |
29 | hsa-miR-655-3p | CASK | -0.97 | 0.05334 | 0.4 | 0.14092 | MirTarget | -0.1 | 0.00892 | NA | |
30 | hsa-miR-664a-3p | CASK | -0.55 | 0.06802 | 0.4 | 0.14092 | mirMAP | -0.22 | 0.00106 | NA | |
31 | hsa-miR-887-3p | CASK | -1.25 | 0.00691 | 0.4 | 0.14092 | MirTarget | -0.14 | 0.00099 | NA | |
32 | hsa-miR-146a-5p | CBX5 | -1.12 | 0.05777 | -0.19 | 0.43077 | mirMAP | -0.11 | 0.00031 | NA | |
33 | hsa-miR-877-5p | CD302 | -1.17 | 0.04417 | -0.37 | 0.35811 | MirTarget | -0.18 | 0.00033 | NA | |
34 | hsa-miR-877-5p | CDH19 | -1.17 | 0.04417 | 0.13 | 0.90694 | MirTarget | -0.37 | 0.0088 | NA | |
35 | hsa-miR-146a-5p | CDON | -1.12 | 0.05777 | -0.13 | 0.81496 | mirMAP | -0.17 | 0.01139 | NA | |
36 | hsa-miR-877-5p | CDR2L | -1.17 | 0.04417 | 1.26 | 0.00688 | miRNAWalker2 validate | -0.12 | 0.04724 | NA | |
37 | hsa-miR-130a-3p | CDS1 | -1.17 | 0.00035 | 1.72 | 8.0E-5 | miRNATAP | -0.31 | 0.00176 | NA | |
38 | hsa-miR-142-3p | CDS1 | -2.4 | 4.0E-5 | 1.72 | 8.0E-5 | miRanda | -0.24 | 1.0E-5 | NA | |
39 | hsa-miR-146b-5p | CDS1 | -1.19 | 0.01322 | 1.72 | 8.0E-5 | miRanda; miRNATAP | -0.18 | 0.0076 | NA | |
40 | hsa-miR-155-5p | CDS1 | -1.43 | 0.00781 | 1.72 | 8.0E-5 | miRNATAP | -0.18 | 0.00282 | NA | |
41 | hsa-miR-299-3p | CDS1 | -1.2 | 0.03353 | 1.72 | 8.0E-5 | miRanda | -0.18 | 0.00248 | NA | |
42 | hsa-miR-486-5p | CDS1 | -1.43 | 0.04021 | 1.72 | 8.0E-5 | miRanda | -0.12 | 0.01335 | NA | |
43 | hsa-miR-146a-5p | CDS2 | -1.12 | 0.05777 | -0.08 | 0.71807 | mirMAP | -0.1 | 0.00019 | NA | |
44 | hsa-miR-146a-5p | CECR6 | -1.12 | 0.05777 | -0.7 | 0.21209 | mirMAP | -0.19 | 0.0055 | NA | |
45 | hsa-miR-130a-3p | CLTC | -1.17 | 0.00035 | 0.1 | 0.65806 | MirTarget; miRNATAP | -0.19 | 6.0E-5 | NA | |
46 | hsa-miR-16-2-3p | CLTC | -1.03 | 0.00735 | 0.1 | 0.65806 | MirTarget | -0.14 | 0.0004 | NA | |
47 | hsa-miR-19a-3p | CLTC | -1.4 | 0.00391 | 0.1 | 0.65806 | MirTarget; miRNATAP | -0.15 | 0 | NA | |
48 | hsa-miR-19b-3p | CLTC | -1.39 | 0.00103 | 0.1 | 0.65806 | MirTarget; miRNATAP | -0.2 | 0 | NA | |
49 | hsa-miR-20a-5p | CLTC | -0.39 | 0.26959 | 0.1 | 0.65806 | mirMAP | -0.12 | 0.00543 | NA | |
50 | hsa-miR-26a-5p | CLTC | -0.6 | 0.02459 | 0.1 | 0.65806 | miRNATAP | -0.24 | 6.0E-5 | NA | |
51 | hsa-miR-26b-5p | CLTC | -1.22 | 0.00085 | 0.1 | 0.65806 | miRNATAP | -0.22 | 0 | NA | |
52 | hsa-miR-30b-5p | CLTC | -0.68 | 0.07316 | 0.1 | 0.65806 | mirMAP | -0.21 | 0 | NA | |
53 | hsa-miR-30c-5p | CLTC | -0.88 | 0.00777 | 0.1 | 0.65806 | mirMAP | -0.25 | 0 | NA | |
54 | hsa-miR-30e-5p | CLTC | -0.99 | 0.00042 | 0.1 | 0.65806 | mirMAP | -0.18 | 0.00142 | NA | |
55 | hsa-miR-576-5p | CLTC | -0.67 | 0.05785 | 0.1 | 0.65806 | MirTarget | -0.11 | 0.01247 | NA | |
56 | hsa-miR-92a-3p | CLTC | -0.42 | 0.1469 | 0.1 | 0.65806 | miRNAWalker2 validate | -0.14 | 0.0132 | NA | |
57 | hsa-miR-29a-3p | COL6A3 | -0.39 | 0.22665 | -0.1 | 0.89132 | MirTarget; miRNATAP | -0.56 | 0.00138 | NA | |
58 | hsa-miR-29b-3p | COL6A3 | -0.39 | 0.34358 | -0.1 | 0.89132 | MirTarget; miRNATAP | -1 | 0 | NA | |
59 | hsa-miR-29c-3p | COL6A3 | -0.13 | 0.74361 | -0.1 | 0.89132 | MirTarget; miRNATAP | -0.93 | 0 | NA | |
60 | hsa-miR-320b | COL6A3 | -0.27 | 0.55127 | -0.1 | 0.89132 | miRanda | -0.24 | 0.04481 | NA | |
61 | hsa-miR-320c | COL6A3 | -0.2 | 0.68946 | -0.1 | 0.89132 | miRanda | -0.24 | 0.03861 | NA | |
62 | hsa-miR-330-3p | COL6A3 | 0.23 | 0.63792 | -0.1 | 0.89132 | miRNATAP | -0.44 | 0.00011 | NA | |
63 | hsa-miR-3613-3p | COL6A3 | -0.97 | 0.05661 | -0.1 | 0.89132 | mirMAP | -0.27 | 0.0149 | NA | |
64 | hsa-miR-362-3p | COL6A3 | -1.21 | 0.01257 | -0.1 | 0.89132 | miRanda | -0.36 | 0.00146 | NA | |
65 | hsa-miR-429 | COL6A3 | 1.86 | 0.00726 | -0.1 | 0.89132 | miRNATAP | -0.37 | 0 | NA | |
66 | hsa-miR-543 | COL6A3 | -1.03 | 0.07135 | -0.1 | 0.89132 | miRanda | -0.19 | 0.04876 | NA | |
67 | hsa-miR-590-3p | COL6A3 | -0.92 | 0.03456 | -0.1 | 0.89132 | miRanda | -0.64 | 0 | NA | |
68 | hsa-miR-877-5p | COL6A3 | -1.17 | 0.04417 | -0.1 | 0.89132 | MirTarget; miRNATAP | -0.32 | 0.00107 | NA | |
69 | hsa-miR-146a-5p | CUEDC1 | -1.12 | 0.05777 | 0.25 | 0.34421 | mirMAP | -0.12 | 0.00022 | NA | |
70 | hsa-miR-146a-5p | CXXC4 | -1.12 | 0.05777 | 0.44 | 0.59138 | MirTarget | -0.34 | 0.00086 | NA | |
71 | hsa-miR-146a-5p | CYB5D1 | -1.12 | 0.05777 | 0.08 | 0.79303 | mirMAP | -0.22 | 0 | NA | |
72 | hsa-miR-877-5p | DLG2 | -1.17 | 0.04417 | -0.5 | 0.51164 | MirTarget | -0.22 | 0.0236 | NA | |
73 | hsa-miR-146a-5p | DTNA | -1.12 | 0.05777 | -1.15 | 0.08809 | MirTarget | -0.3 | 0.00028 | NA | |
74 | hsa-miR-877-5p | EGFR | -1.17 | 0.04417 | 0.65 | 0.25306 | mirMAP | -0.27 | 0.00018 | NA | |
75 | hsa-let-7f-2-3p | EID1 | -0.39 | 0.50126 | -0.18 | 0.41215 | MirTarget | -0.13 | 7.0E-5 | NA | |
76 | hsa-miR-200b-5p | EID1 | 0.86 | 0.18327 | -0.18 | 0.41215 | MirTarget | -0.13 | 1.0E-5 | NA | |
77 | hsa-miR-455-5p | EID1 | -0.23 | 0.54044 | -0.18 | 0.41215 | miRanda | -0.14 | 0.00173 | NA | |
78 | hsa-miR-877-5p | EMP1 | -1.17 | 0.04417 | 0.76 | 0.20317 | MirTarget | -0.24 | 0.00194 | NA | |
79 | hsa-miR-877-5p | FAT3 | -1.17 | 0.04417 | -1.22 | 0.10046 | MirTarget | -0.21 | 0.02711 | NA | |
80 | hsa-miR-877-5p | FLI1 | -1.17 | 0.04417 | -1.49 | 0.00419 | MirTarget; miRNATAP | -0.15 | 0.0296 | NA | |
81 | hsa-miR-877-5p | FOXC1 | -1.17 | 0.04417 | 0.86 | 0.09648 | miRNAWalker2 validate | -0.19 | 0.00532 | NA | |
82 | hsa-miR-146a-5p | FOXK1 | -1.12 | 0.05777 | -0.08 | 0.78218 | mirMAP | -0.13 | 0.00026 | NA | |
83 | hsa-miR-342-3p | FOXM1 | -1.51 | 0.00036 | 1.25 | 0.04338 | miRanda | -0.22 | 0.03688 | 25066298; 27162244; 27716361 | miR 342 3p suppresses proliferation migration and invasion by targeting FOXM1 in human cervical cancer; In this study we reported that FOXM1 is directly targeted by miR-342-3p which is down-regulated along with its host gene EVL in human cervical cancer tissues compared to the adjacent normal tissues; FOXM1 is upregulated and negatively correlates with miR-342-3p in cervical cancer tissues and the overexpression of FOXM1 rescues the phenotype changes induced by the overexpression of miR-342-3p;FOXM1 and FOXQ1 Are Promising Prognostic Biomarkers and Novel Targets of Tumor Suppressive miR 342 in Human Colorectal Cancer; Furthermore using bioinformatic approaches we identified miR-342 as a novel regulator of both FOXM1 and FOXQ1; Collectively we have firstly identified FOXM1 and FOXQ1 as promising prognostic biomarkers in colorectal cancer patients and provided novel evidence that therapeutic targeting of these genes or miR-342 may be a potential treatment approach in colorectal cancer patients;Long non coding RNA H19 regulates FOXM1 expression by competitively binding endogenous miR 342 3p in gallbladder cancer; QRT-PCR and Western-blotting assays demonstrated that H19 silencing down-regulated whereas over-expression enhanced the expression of miR-342-3p targeting FOXM1 through competitively 'sponging' miR-342-3p; Our results suggest a potential ceRNA regulatory network involving H19 regulates FOXM1 expression by competitively binding endogenous miR-342-3p in GBC |
84 | hsa-miR-361-5p | FOXM1 | -0.3 | 0.18864 | 1.25 | 0.04338 | miRanda | -0.52 | 0.01346 | NA | |
85 | hsa-miR-146a-5p | FOXP2 | -1.12 | 0.05777 | 0.26 | 0.75107 | mirMAP | -0.31 | 0.00274 | NA | |
86 | hsa-miR-877-5p | FOXP2 | -1.17 | 0.04417 | 0.26 | 0.75107 | miRNATAP | -0.24 | 0.02828 | NA | |
87 | hsa-miR-146a-5p | FZD3 | -1.12 | 0.05777 | -0.28 | 0.48833 | MirTarget | -0.2 | 6.0E-5 | NA | |
88 | hsa-miR-103a-2-5p | GALNT10 | -2.06 | 0.00116 | 0.32 | 0.41609 | mirMAP | -0.12 | 0.00901 | NA | |
89 | hsa-miR-139-5p | GALNT10 | -1.64 | 0.00654 | 0.32 | 0.41609 | miRanda | -0.15 | 0.00144 | NA | |
90 | hsa-miR-181c-5p | GALNT10 | 0.39 | 0.3054 | 0.32 | 0.41609 | mirMAP | -0.17 | 0.0243 | NA | |
91 | hsa-miR-204-5p | GALNT10 | -1.13 | 0.19074 | 0.32 | 0.41609 | mirMAP | -0.12 | 0.0004 | NA | |
92 | hsa-miR-20a-3p | GALNT10 | -1.06 | 0.01854 | 0.32 | 0.41609 | mirMAP | -0.21 | 0.00113 | NA | |
93 | hsa-miR-2110 | GALNT10 | 0.05 | 0.94584 | 0.32 | 0.41609 | mirMAP | -0.15 | 0.00115 | NA | |
94 | hsa-miR-26a-5p | GALNT10 | -0.6 | 0.02459 | 0.32 | 0.41609 | mirMAP; miRNATAP | -0.32 | 0.00507 | NA | |
95 | hsa-miR-26b-5p | GALNT10 | -1.22 | 0.00085 | 0.32 | 0.41609 | mirMAP; miRNATAP | -0.25 | 0.00191 | NA | |
96 | hsa-miR-296-5p | GALNT10 | -1.02 | 0.0303 | 0.32 | 0.41609 | MirTarget | -0.23 | 0.00012 | NA | |
97 | hsa-miR-29a-5p | GALNT10 | -0.6 | 0.06643 | 0.32 | 0.41609 | mirMAP | -0.21 | 0.02206 | NA | |
98 | hsa-miR-3065-3p | GALNT10 | 0.92 | 0.14952 | 0.32 | 0.41609 | miRNATAP | -0.2 | 0 | NA | |
99 | hsa-miR-30d-3p | GALNT10 | -0.36 | 0.32354 | 0.32 | 0.41609 | mirMAP | -0.16 | 0.04411 | NA | |
100 | hsa-miR-330-3p | GALNT10 | 0.23 | 0.63792 | 0.32 | 0.41609 | MirTarget; PITA; mirMAP | -0.19 | 0.00196 | NA | |
101 | hsa-miR-335-5p | GALNT10 | -0.91 | 0.05683 | 0.32 | 0.41609 | mirMAP | -0.25 | 3.0E-5 | NA | |
102 | hsa-miR-33a-5p | GALNT10 | -0.99 | 0.06458 | 0.32 | 0.41609 | mirMAP | -0.14 | 0.00787 | NA | |
103 | hsa-miR-33b-5p | GALNT10 | 0.62 | 0.3293 | 0.32 | 0.41609 | mirMAP | -0.2 | 2.0E-5 | NA | |
104 | hsa-miR-3607-3p | GALNT10 | -0.1 | 0.81827 | 0.32 | 0.41609 | mirMAP | -0.18 | 0.00877 | NA | |
105 | hsa-miR-361-5p | GALNT10 | -0.3 | 0.18864 | 0.32 | 0.41609 | miRanda | -0.35 | 0.00828 | NA | |
106 | hsa-miR-369-3p | GALNT10 | -0.83 | 0.17364 | 0.32 | 0.41609 | mirMAP | -0.16 | 0.001 | NA | |
107 | hsa-miR-374a-5p | GALNT10 | -0.77 | 0.02145 | 0.32 | 0.41609 | mirMAP | -0.19 | 0.03166 | NA | |
108 | hsa-miR-374b-5p | GALNT10 | -0.94 | 0.0014 | 0.32 | 0.41609 | mirMAP | -0.35 | 0.00053 | NA | |
109 | hsa-miR-376a-5p | GALNT10 | -1.11 | 0.0539 | 0.32 | 0.41609 | mirMAP | -0.19 | 0.0002 | NA | |
110 | hsa-miR-377-3p | GALNT10 | -1.31 | 0.02275 | 0.32 | 0.41609 | mirMAP | -0.15 | 0.00243 | NA | |
111 | hsa-miR-500a-5p | GALNT10 | -1.1 | 0.01791 | 0.32 | 0.41609 | mirMAP | -0.17 | 0.00655 | NA | |
112 | hsa-miR-582-5p | GALNT10 | -0.24 | 0.6387 | 0.32 | 0.41609 | mirMAP | -0.16 | 0.00483 | NA | |
113 | hsa-miR-590-3p | GALNT10 | -0.92 | 0.03456 | 0.32 | 0.41609 | miRanda; mirMAP | -0.25 | 0.0002 | NA | |
114 | hsa-miR-590-5p | GALNT10 | -0.98 | 0.00534 | 0.32 | 0.41609 | mirMAP | -0.28 | 0.00077 | NA | |
115 | hsa-miR-671-5p | GALNT10 | -0.16 | 0.729 | 0.32 | 0.41609 | MirTarget | -0.12 | 0.04827 | NA | |
116 | hsa-miR-7-1-3p | GALNT10 | -0.73 | 0.0834 | 0.32 | 0.41609 | mirMAP | -0.31 | 1.0E-5 | NA | |
117 | hsa-miR-769-3p | GALNT10 | -0.42 | 0.40382 | 0.32 | 0.41609 | MirTarget | -0.15 | 0.01059 | NA | |
118 | hsa-miR-93-3p | GALNT10 | -1.17 | 0.00228 | 0.32 | 0.41609 | mirMAP | -0.16 | 0.03779 | NA | |
119 | hsa-miR-877-5p | GAS7 | -1.17 | 0.04417 | -0.64 | 0.20432 | mirMAP | -0.17 | 0.00956 | NA | |
120 | hsa-miR-877-5p | GLIPR1 | -1.17 | 0.04417 | -1.35 | 0.01572 | MirTarget | -0.23 | 0.00184 | NA | |
121 | hsa-miR-146a-5p | GNAO1 | -1.12 | 0.05777 | 0.31 | 0.66625 | mirMAP | -0.35 | 8.0E-5 | NA | |
122 | hsa-miR-877-5p | GNB4 | -1.17 | 0.04417 | -0.95 | 0.05626 | MirTarget | -0.19 | 0.00331 | NA | |
123 | hsa-miR-146a-5p | GRIA3 | -1.12 | 0.05777 | 0.4 | 0.66415 | MirTarget | -0.38 | 0.00076 | NA | |
124 | hsa-miR-877-5p | GRIN2A | -1.17 | 0.04417 | 0.58 | 0.47505 | mirMAP | -0.21 | 0.0441 | NA | |
125 | hsa-miR-146a-5p | GRSF1 | -1.12 | 0.05777 | 0.37 | 0.06369 | MirTarget; mirMAP | -0.13 | 0 | NA | |
126 | hsa-miR-877-5p | HEYL | -1.17 | 0.04417 | 0.19 | 0.73062 | MirTarget | -0.18 | 0.01464 | NA | |
127 | hsa-miR-877-5p | HIF3A | -1.17 | 0.04417 | -0.32 | 0.63544 | mirMAP | -0.2 | 0.02564 | NA | |
128 | hsa-miR-877-5p | HLA-DRA | -1.17 | 0.04417 | -1.52 | 0.01113 | MirTarget | -0.23 | 0.00301 | NA | |
129 | hsa-miR-335-5p | HSD11B1 | -0.91 | 0.05683 | -0.44 | 0.54562 | miRNAWalker2 validate | -0.29 | 0.00839 | NA | |
130 | hsa-miR-455-5p | HSD11B1 | -0.23 | 0.54044 | -0.44 | 0.54562 | miRanda | -0.5 | 0.00041 | NA | |
131 | hsa-miR-577 | HSD11B1 | 0.81 | 0.31426 | -0.44 | 0.54562 | miRNATAP | -0.31 | 0 | NA | |
132 | hsa-miR-590-3p | HSD11B1 | -0.92 | 0.03456 | -0.44 | 0.54562 | miRanda; mirMAP | -0.5 | 3.0E-5 | NA | |
133 | hsa-miR-7-1-3p | HSD11B1 | -0.73 | 0.0834 | -0.44 | 0.54562 | MirTarget | -0.33 | 0.00832 | NA | |
134 | hsa-miR-877-5p | IGF2BP2 | -1.17 | 0.04417 | 0.7 | 0.34724 | miRNAWalker2 validate; MirTarget; miRNATAP | -0.2 | 0.04187 | NA | |
135 | hsa-miR-877-5p | IL17RD | -1.17 | 0.04417 | -0.42 | 0.32296 | mirMAP | -0.18 | 0.00089 | NA | |
136 | hsa-miR-877-5p | ITGA9 | -1.17 | 0.04417 | -0.7 | 0.28742 | mirMAP | -0.23 | 0.00837 | NA | |
137 | hsa-miR-877-5p | ITGB8 | -1.17 | 0.04417 | 1.47 | 0.00341 | MirTarget | -0.15 | 0.02551 | NA | |
138 | hsa-miR-146a-5p | KCNB1 | -1.12 | 0.05777 | -0.26 | 0.80086 | mirMAP | -0.41 | 0.00161 | NA | |
139 | hsa-miR-877-5p | KCNJ15 | -1.17 | 0.04417 | -0.76 | 0.51059 | MirTarget | -0.45 | 0.00269 | NA | |
140 | hsa-miR-146a-5p | KIAA1958 | -1.12 | 0.05777 | 0.34 | 0.45736 | mirMAP | -0.23 | 3.0E-5 | NA | |
141 | hsa-miR-101-5p | KIF26B | -0.7 | 0.03679 | 0.51 | 0.44044 | mirMAP | -0.39 | 0.00864 | NA | |
142 | hsa-miR-106a-5p | KIF26B | -1.43 | 0.00117 | 0.51 | 0.44044 | miRNATAP | -0.23 | 0.0392 | NA | |
143 | hsa-miR-106b-5p | KIF26B | -0.81 | 0.00943 | 0.51 | 0.44044 | miRNATAP | -0.66 | 2.0E-5 | NA | |
144 | hsa-miR-130b-3p | KIF26B | -0.37 | 0.37726 | 0.51 | 0.44044 | mirMAP | -0.32 | 0.0063 | NA | |
145 | hsa-miR-130b-5p | KIF26B | -0.5 | 0.28032 | 0.51 | 0.44044 | mirMAP | -0.3 | 0.00395 | NA | |
146 | hsa-miR-141-3p | KIF26B | 1.13 | 0.09667 | 0.51 | 0.44044 | mirMAP | -0.27 | 0.00011 | NA | |
147 | hsa-miR-148a-3p | KIF26B | -0.19 | 0.72463 | 0.51 | 0.44044 | mirMAP | -0.29 | 0.00136 | NA | |
148 | hsa-miR-148b-3p | KIF26B | -0.1 | 0.7723 | 0.51 | 0.44044 | mirMAP | -1.06 | 0 | NA | |
149 | hsa-miR-16-2-3p | KIF26B | -1.03 | 0.00735 | 0.51 | 0.44044 | mirMAP | -0.29 | 0.02279 | NA | |
150 | hsa-miR-182-5p | KIF26B | 0.19 | 0.7303 | 0.51 | 0.44044 | mirMAP | -0.34 | 8.0E-5 | NA |
Num | GO | Overlap | Size | P Value | Adj. P Value |
---|
Num | GO | Overlap | Size | P Value | Adj. P Value |
---|
Num | GO | Overlap | Size | P Value | Adj. P Value |
---|
Num | Pathway | Pathview | Overlap | Size | P Value | Adj. P Value |
---|---|---|---|---|---|---|
1 | PI3K_Akt_signaling_pathway_hsa04151 | 7 | 352 | 0.01393 | 0.159 | |
2 | Focal_adhesion_hsa04510 | 5 | 199 | 0.01467 | 0.159 | |
3 | Rap1_signaling_pathway_hsa04015 | 5 | 206 | 0.0168 | 0.159 | |
4 | Regulation_of_actin_cytoskeleton_hsa04810 | 5 | 208 | 0.01744 | 0.159 | |
5 | Cell_adhesion_molecules_.CAMs._hsa04514 | 4 | 145 | 0.02087 | 0.159 | |
6 | Wnt_signaling_pathway_hsa04310 | 4 | 146 | 0.02134 | 0.159 | |
7 | ECM_receptor_interaction_hsa04512 | 3 | 82 | 0.02141 | 0.159 | |
8 | Jak_STAT_signaling_pathway_hsa04630 | 4 | 162 | 0.02977 | 0.1935 | |
9 | cAMP_signaling_pathway_hsa04024 | 4 | 198 | 0.05509 | 0.3183 | |
10 | Apelin_signaling_pathway_hsa04371 | 3 | 137 | 0.07651 | 0.3467 | |
11 | Signaling_pathways_regulating_pluripotency_of_stem_cells_hsa04550 | 3 | 139 | 0.07914 | 0.3467 | |
12 | Ras_signaling_pathway_hsa04014 | 4 | 232 | 0.08697 | 0.3467 | |
13 | Phospholipase_D_signaling_pathway_hsa04072 | 3 | 146 | 0.08862 | 0.3467 | |
14 | Adherens_junction_hsa04520 | 2 | 72 | 0.09502 | 0.3467 | |
15 | Hippo_signaling_pathway_hsa04390 | 3 | 154 | 0.1 | 0.3467 | |
16 | TGF_beta_signaling_pathway_hsa04350 | 2 | 84 | 0.1227 | 0.394 | |
17 | Gap_junction_hsa04540 | 2 | 88 | 0.1324 | 0.394 | |
18 | Neuroactive_ligand_receptor_interaction_hsa04080 | 4 | 278 | 0.1412 | 0.394 | |
19 | Calcium_signaling_pathway_hsa04020 | 3 | 182 | 0.144 | 0.394 | |
20 | Phosphatidylinositol_signaling_system_hsa04070 | 2 | 99 | 0.1596 | 0.4016 | |
21 | HIF_1_signaling_pathway_hsa04066 | 2 | 100 | 0.1622 | 0.4016 | |
22 | Oocyte_meiosis_hsa04114 | 2 | 124 | 0.2246 | 0.5309 | |
23 | FoxO_signaling_pathway_hsa04068 | 2 | 132 | 0.2459 | 0.5559 | |
24 | Endocytosis_hsa04144 | 3 | 244 | 0.2572 | 0.5572 | |
25 | Cytokine_cytokine_receptor_interaction_hsa04060 | 3 | 270 | 0.308 | 0.616 | |
26 | Tight_junction_hsa04530 | 2 | 170 | 0.3467 | 0.6676 |
Num | lncRNA | miRNAs | miRNAs count | Gene | Sponge regulatory network | lncRNA log2FC | lncRNA pvalue | Gene log2FC | Gene pvalue | lncRNA-gene Pearson correlation |
---|---|---|---|---|---|---|---|---|---|---|
1 | HCG11 |
hsa-miR-130b-3p;hsa-miR-148b-3p;hsa-miR-29a-3p;hsa-miR-29b-3p;hsa-miR-29c-3p;hsa-miR-301a-3p;hsa-miR-3065-5p;hsa-miR-30d-3p;hsa-miR-3613-3p;hsa-miR-590-3p;hsa-miR-592 | 11 | ROBO1 | Sponge network | -0.31 | 0.48859 | -0.796 | 0.12278 | 0.61 |
2 | HCG11 |
hsa-let-7a-3p;hsa-let-7f-1-3p;hsa-miR-106b-5p;hsa-miR-15a-5p;hsa-miR-16-5p;hsa-miR-17-5p;hsa-miR-182-5p;hsa-miR-194-5p;hsa-miR-200b-3p;hsa-miR-200c-3p;hsa-miR-20a-5p;hsa-miR-23b-5p;hsa-miR-29a-3p;hsa-miR-29b-3p;hsa-miR-29c-3p;hsa-miR-320c;hsa-miR-3607-3p;hsa-miR-3613-3p;hsa-miR-664a-3p;hsa-miR-7-1-3p;hsa-miR-93-5p | 21 | ZNF532 | Sponge network | -0.31 | 0.48859 | -0.581 | 0.1535 | 0.563 |
3 | HCG11 |
hsa-let-7a-3p;hsa-miR-141-3p;hsa-miR-183-5p;hsa-miR-192-3p;hsa-miR-200a-3p;hsa-miR-200b-3p;hsa-miR-26b-3p;hsa-miR-27b-3p;hsa-miR-3065-5p;hsa-miR-3607-3p;hsa-miR-3613-3p;hsa-miR-362-3p;hsa-miR-590-3p;hsa-miR-592 | 14 | NRP2 | Sponge network | -0.31 | 0.48859 | 0.313 | 0.54824 | 0.467 |
4 | UCA1 |
hsa-miR-101-5p;hsa-miR-130b-5p;hsa-miR-204-5p;hsa-miR-20b-5p;hsa-miR-29b-2-5p;hsa-miR-3065-5p;hsa-miR-340-5p;hsa-miR-501-5p;hsa-miR-502-5p;hsa-miR-582-5p;hsa-miR-590-3p;hsa-miR-628-3p;hsa-miR-7-1-3p;hsa-miR-877-5p | 14 | KIF26B | Sponge network | 1.481 | 0.28957 | 0.514 | 0.44044 | 0.466 |
5 | DIO3OS |
hsa-miR-106a-5p;hsa-miR-130b-3p;hsa-miR-130b-5p;hsa-miR-148a-3p;hsa-miR-148b-3p;hsa-miR-204-5p;hsa-miR-20b-5p;hsa-miR-29b-2-5p;hsa-miR-29b-3p;hsa-miR-29c-3p;hsa-miR-301a-3p;hsa-miR-330-3p;hsa-miR-3613-3p;hsa-miR-377-3p;hsa-miR-455-3p;hsa-miR-501-5p;hsa-miR-582-5p;hsa-miR-589-3p;hsa-miR-769-5p;hsa-miR-877-5p | 20 | KIF26B | Sponge network | 1.18 | 0.0997 | 0.514 | 0.44044 | 0.435 |
6 | EGOT | hsa-let-7g-3p;hsa-let-7g-5p;hsa-miR-135a-5p;hsa-miR-154-5p;hsa-miR-340-5p;hsa-miR-369-3p;hsa-miR-421;hsa-miR-495-3p;hsa-miR-655-3p;hsa-miR-7-1-3p | 10 | SKIL | Sponge network | -1.196 | 0.1622 | 0.033 | 0.94505 | 0.417 |
7 | HCG11 |
hsa-let-7g-3p;hsa-let-7g-5p;hsa-miR-1301-3p;hsa-miR-154-5p;hsa-miR-19a-3p;hsa-miR-19b-3p;hsa-miR-26b-5p;hsa-miR-3065-5p;hsa-miR-340-5p;hsa-miR-3607-3p;hsa-miR-369-3p;hsa-miR-485-3p;hsa-miR-590-3p;hsa-miR-655-3p;hsa-miR-664a-3p;hsa-miR-7-1-3p;hsa-miR-877-5p | 17 | SKIL | Sponge network | -0.31 | 0.48859 | 0.033 | 0.94505 | 0.377 |
8 | UCA1 |
hsa-let-7g-5p;hsa-miR-126-5p;hsa-miR-135a-5p;hsa-miR-154-5p;hsa-miR-3065-5p;hsa-miR-340-5p;hsa-miR-374a-5p;hsa-miR-374b-5p;hsa-miR-495-3p;hsa-miR-539-5p;hsa-miR-582-5p;hsa-miR-590-3p;hsa-miR-7-1-3p;hsa-miR-877-5p | 14 | SKIL | Sponge network | 1.481 | 0.28957 | 0.033 | 0.94505 | 0.375 |
9 | EMX2OS |
hsa-let-7f-1-3p;hsa-miR-106b-5p;hsa-miR-16-5p;hsa-miR-182-5p;hsa-miR-194-5p;hsa-miR-200b-3p;hsa-miR-200c-3p;hsa-miR-29b-3p;hsa-miR-29c-3p;hsa-miR-32-5p;hsa-miR-7-1-3p | 11 | ZNF532 | Sponge network | 0.959 | 0.25398 | -0.581 | 0.1535 | 0.355 |
10 | EMX2OS |
hsa-miR-106b-5p;hsa-miR-130b-3p;hsa-miR-130b-5p;hsa-miR-141-3p;hsa-miR-148a-3p;hsa-miR-148b-3p;hsa-miR-182-5p;hsa-miR-192-3p;hsa-miR-200a-3p;hsa-miR-29b-2-5p;hsa-miR-29b-3p;hsa-miR-29c-3p;hsa-miR-301a-3p;hsa-miR-3065-5p;hsa-miR-454-3p;hsa-miR-7-1-3p;hsa-miR-877-5p | 17 | KIF26B | Sponge network | 0.959 | 0.25398 | 0.514 | 0.44044 | 0.354 |
11 | HCG11 |
hsa-miR-101-5p;hsa-miR-106b-5p;hsa-miR-130b-3p;hsa-miR-130b-5p;hsa-miR-141-3p;hsa-miR-148b-3p;hsa-miR-16-2-3p;hsa-miR-182-5p;hsa-miR-192-3p;hsa-miR-19a-3p;hsa-miR-19b-3p;hsa-miR-200a-3p;hsa-miR-29b-2-5p;hsa-miR-29b-3p;hsa-miR-29c-3p;hsa-miR-301a-3p;hsa-miR-3065-5p;hsa-miR-340-5p;hsa-miR-3613-3p;hsa-miR-501-5p;hsa-miR-590-3p;hsa-miR-664a-3p;hsa-miR-7-1-3p;hsa-miR-877-5p | 24 | KIF26B | Sponge network | -0.31 | 0.48859 | 0.514 | 0.44044 | 0.349 |
12 | H19 | hsa-miR-141-3p;hsa-miR-148b-3p;hsa-miR-192-3p;hsa-miR-200a-3p;hsa-miR-29b-2-5p;hsa-miR-29b-3p;hsa-miR-29c-3p;hsa-miR-301a-3p;hsa-miR-454-3p;hsa-miR-589-3p;hsa-miR-769-5p | 11 | KIF26B | Sponge network | -0.02 | 0.98077 | 0.514 | 0.44044 | 0.339 |
13 | RFPL1S |
hsa-let-7a-3p;hsa-let-7f-1-3p;hsa-miR-106b-5p;hsa-miR-17-5p;hsa-miR-182-5p;hsa-miR-194-5p;hsa-miR-200b-3p;hsa-miR-200c-3p;hsa-miR-20a-5p;hsa-miR-23b-5p;hsa-miR-32-5p;hsa-miR-429;hsa-miR-92a-3p;hsa-miR-93-5p;hsa-miR-96-5p | 15 | ZNF532 | Sponge network | -0.457 | 0.43621 | -0.581 | 0.1535 | 0.325 |
14 | EMX2OS |
hsa-miR-130b-3p;hsa-miR-148b-3p;hsa-miR-29b-3p;hsa-miR-29c-3p;hsa-miR-301a-3p;hsa-miR-3065-5p;hsa-miR-30d-3p;hsa-miR-32-5p;hsa-miR-454-3p;hsa-miR-592 | 10 | ROBO1 | Sponge network | 0.959 | 0.25398 | -0.796 | 0.12278 | 0.305 |
15 | DIO3OS |
hsa-miR-139-5p;hsa-miR-183-5p;hsa-miR-188-3p;hsa-miR-204-5p;hsa-miR-26b-3p;hsa-miR-27b-3p;hsa-miR-330-3p;hsa-miR-3607-3p;hsa-miR-3613-3p;hsa-miR-628-5p | 10 | NRP2 | Sponge network | 1.18 | 0.0997 | 0.313 | 0.54824 | 0.301 |
16 | KCNQ1OT1 |
hsa-miR-126-5p;hsa-miR-1301-3p;hsa-miR-154-5p;hsa-miR-340-5p;hsa-miR-369-3p;hsa-miR-374a-5p;hsa-miR-421;hsa-miR-485-3p;hsa-miR-495-3p;hsa-miR-539-5p;hsa-miR-590-3p;hsa-miR-655-3p;hsa-miR-98-5p | 13 | SKIL | Sponge network | 0.495 | 0.30013 | 0.033 | 0.94505 | 0.289 |
17 | HCP5 | hsa-miR-181c-5p;hsa-miR-296-5p;hsa-miR-3065-3p;hsa-miR-330-3p;hsa-miR-33b-5p;hsa-miR-376a-5p;hsa-miR-377-3p;hsa-miR-582-5p;hsa-miR-671-5p;hsa-miR-769-3p | 10 | GALNT10 | Sponge network | -0.577 | 0.20814 | 0.323 | 0.41609 | 0.289 |
18 | UCA1 |
hsa-miR-103a-2-5p;hsa-miR-204-5p;hsa-miR-26a-5p;hsa-miR-296-5p;hsa-miR-33a-5p;hsa-miR-33b-5p;hsa-miR-374a-5p;hsa-miR-374b-5p;hsa-miR-500a-5p;hsa-miR-582-5p;hsa-miR-590-3p;hsa-miR-590-5p;hsa-miR-671-5p;hsa-miR-7-1-3p | 14 | GALNT10 | Sponge network | 1.481 | 0.28957 | 0.323 | 0.41609 | 0.26 |