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This regulatory network was inferred from the input dataset. The miRNAs and mRNAs are presented as round and rectangle nodes respectively. The numerical value popped up upon mouse over the gene node is the log2 transformed fold-change of the gene expression between the two groups. All of the nodes are clickable, and the detailed information of the miRNAs/mRNAs and related cancer pathway will be displayed in another window. The edges between nodes are supported by both interactions (predicted or experimentally verified) and correlations learnt from cancer dataset. The numerical value popped up upon mouse over the edge is the correlation beat value (effect size) between the two nodes. The experimental evidences of the edges reported in previous cancer studies are highlighted by red/orange color. All of these information can be accessed by the "mouse-over" action. This network shows a full map of the miRNA-mRNA regulation of the input gene list(s), and the hub miRNAs (with the high network degree/betweenness centrality) would be the potential cancer drivers or tumor suppressors. The full result table can be accessed in the "Regulations" tab.

"miRNACancerMAP" is also a network visualization tool for users to draw their regulatory network by personal customization. Users can set the complexity of the network by limiting the number of nodes or edges. And the color of the nodes can be defined by different categories of the mRNAs and miRNAs, such as Gene-Ontology, pathway, and expression status. Users can also select to use network degree or network betweenness centrality to define the node size. And edges can be black or colored by the correlation. Purple edge means negative correlation (mostly found between miRNA and mRNA), and blue edge means positive correlation (found in PPI or miRNA-miRNA sponge effect). We can also add the protein-protein interactions (PPI) into the network. This result will show the cluster of genes regulated by some specific miRNAs. Additionally, miRNA-miRNA edges can be added by the "miRNA sponge" button, presenting some clusters of miRNAs that have the interactions via sponge effect.

miRNA-gene regulations

(Download full result)

Num microRNA           Gene miRNA log2FC miRNA pvalue Gene log2FC Gene pvalue Interaction Correlation beta Correlation P-value PMID Reported in cancer studies
1 hsa-miR-128-3p ABL1 0.98 6.0E-5 -0.96 0 MirTarget -0.16 0.00096 NA
2 hsa-miR-141-3p ABL1 1.46 0.00116 -0.96 0 MirTarget -0.19 0 NA
3 hsa-miR-142-5p ABL1 1.56 1.0E-5 -0.96 0 MirTarget -0.17 0 NA
4 hsa-miR-15b-3p ABL1 1.76 0 -0.96 0 MirTarget -0.15 4.0E-5 NA
5 hsa-miR-15b-5p ABL1 1.62 0 -0.96 0 mirMAP -0.2 0 NA
6 hsa-miR-16-5p ABL1 1.01 1.0E-5 -0.96 0 mirMAP -0.28 0 NA
7 hsa-miR-19a-3p ABL1 1.27 0.00011 -0.96 0 mirMAP -0.16 2.0E-5 NA
8 hsa-miR-200a-3p ABL1 0.72 0.19391 -0.96 0 MirTarget -0.12 0 NA
9 hsa-miR-29a-5p ABL1 0.59 0.02301 -0.96 0 MirTarget -0.13 0.00827 NA
10 hsa-miR-30b-5p ABL1 -0.43 0.05936 -0.96 0 MirTarget; miRNATAP -0.14 0.0083 NA
11 hsa-miR-30e-5p ABL1 -0.57 0.01125 -0.96 0 MirTarget; miRNATAP -0.15 0.00794 NA
12 hsa-miR-330-5p ABL1 0.49 0.05122 -0.96 0 MirTarget -0.24 0 NA
13 hsa-miR-423-5p ABL1 0.83 0.00079 -0.96 0 MirTarget -0.15 0.00245 NA
14 hsa-miR-484 ABL1 0.71 0.00234 -0.96 0 miRNAWalker2 validate -0.26 0 NA
15 hsa-miR-503-5p ABL1 1.89 0 -0.96 0 mirMAP -0.1 0.00051 NA
16 hsa-miR-30a-3p ANAPC10 -1.73 0 0.45 0.00577 MirTarget; miRNATAP -0.13 8.0E-5 NA
17 hsa-miR-139-5p ANAPC7 -1.83 0 0.58 0.00037 miRanda -0.1 0.00535 NA
18 hsa-miR-30c-2-3p ANAPC7 -1.14 0.00085 0.58 0.00037 MirTarget -0.12 0.00048 NA
19 hsa-miR-125a-3p ATM 1.2 0.00164 -0.39 0.08341 miRanda -0.13 0.00188 NA
20 hsa-miR-203a-3p ATM 1.45 0.03941 -0.39 0.08341 MirTarget -0.14 0 24145123; 27542403 miR 203 induces oxaliplatin resistance in colorectal cancer cells by negatively regulating ATM kinase; In silico analysis identified ataxia telangiectasia mutated ATM a primary mediator of the DNA damage response as a potential target of miR-203; Using TCGA database we identified a significant reverse correlation of miR-203 and ATM expression in CRC tissues; We validated ATM as a bona fide target of miR-203 in CRC cells; Mutation of the putative miR-203 binding site in the 3' untranslated region 3'UTR of the ATM mRNA abolished the inhibitory effect of miR-203 on ATM;MiR 203 inhibits tumor invasion and metastasis in gastric cancer by ATM; Our results showed that miR-203 was significantly downregulated in gastric cancer tissues and cells while ataxia telangiectasia mutated kinase ATM was upregulated in gastric cancer tissues and cells and was directly regulated by miR-203; ATM knockdown phenocopied the effect of miR-203 overexpression
21 hsa-miR-590-5p ATM 1.04 0.00027 -0.39 0.08341 mirMAP -0.17 0.00247 NA
22 hsa-miR-30b-5p ATR -0.43 0.05936 0.73 0.00017 mirMAP -0.19 0.00265 NA
23 hsa-miR-139-5p BUB1 -1.83 0 3.99 0 miRanda -0.52 0 NA
24 hsa-miR-139-5p BUB3 -1.83 0 0.88 0 miRanda -0.16 0 NA
25 hsa-miR-107 CCNA1 0.9 5.0E-5 1.85 0.16644 miRanda -2.11 0 NA
26 hsa-miR-30a-5p CCNA1 -1.72 0 1.85 0.16644 MirTarget -0.88 0.00139 NA
27 hsa-miR-30b-5p CCNA1 -0.43 0.05936 1.85 0.16644 MirTarget -1.24 0.00319 NA
28 hsa-miR-30d-5p CCNA1 -0.55 0.01401 1.85 0.16644 MirTarget -2.13 0 NA
29 hsa-miR-335-5p CCNA1 1.6 6.0E-5 1.85 0.16644 miRNAWalker2 validate -1.05 1.0E-5 NA
30 hsa-miR-129-5p CCNA2 -2.57 0 2.9 0 miRanda -0.17 7.0E-5 NA
31 hsa-miR-218-5p CCNA2 -0.99 0.01083 2.9 0 MirTarget -0.16 0.00836 NA
32 hsa-miR-29c-3p CCNA2 -1.62 0 2.9 0 MirTarget -0.44 0 NA
33 hsa-miR-139-5p CCNB1 -1.83 0 2.86 0 miRanda -0.49 0 NA
34 hsa-miR-338-3p CCND1 -0.96 0.01915 0.62 0.1312 miRNAWalker2 validate; miRTarBase; miRanda -0.24 0.00086 NA
35 hsa-let-7a-3p CCND2 0.5 0.04111 -0.5 0.3 mirMAP -0.54 0.0001 20418948 MicroRNA let 7a inhibits proliferation of human prostate cancer cells in vitro and in vivo by targeting E2F2 and CCND2
36 hsa-let-7b-3p CCND2 0.22 0.29604 -0.5 0.3 mirMAP -0.46 0.00588 NA
37 hsa-miR-106b-5p CCND2 1.71 0 -0.5 0.3 miRNAWalker2 validate; miRTarBase; miRNATAP -0.42 9.0E-5 NA
38 hsa-miR-130b-5p CCND2 0.7 0.05101 -0.5 0.3 mirMAP -0.39 2.0E-5 NA
39 hsa-miR-141-3p CCND2 1.46 0.00116 -0.5 0.3 MirTarget; TargetScan -0.21 0.00436 NA
40 hsa-miR-15b-5p CCND2 1.62 0 -0.5 0.3 miRNATAP -0.44 0.00021 NA
41 hsa-miR-16-2-3p CCND2 1.8 0 -0.5 0.3 mirMAP -0.55 0 NA
42 hsa-miR-16-5p CCND2 1.01 1.0E-5 -0.5 0.3 miRNAWalker2 validate; miRNATAP -0.67 1.0E-5 NA
43 hsa-miR-181a-2-3p CCND2 0.9 0.00083 -0.5 0.3 mirMAP -0.38 0.00236 NA
44 hsa-miR-182-5p CCND2 0.89 0.03106 -0.5 0.3 miRNAWalker2 validate; miRTarBase; miRNATAP -0.32 9.0E-5 NA
45 hsa-miR-183-5p CCND2 1.66 0.00052 -0.5 0.3 miRNATAP -0.29 2.0E-5 NA
46 hsa-miR-19b-3p CCND2 0.76 0.00653 -0.5 0.3 miRNAWalker2 validate; MirTarget; miRNATAP -0.32 0.00853 NA
47 hsa-miR-21-3p CCND2 1.75 0 -0.5 0.3 mirMAP -0.33 0.0051 NA
48 hsa-miR-224-3p CCND2 1.52 0.0065 -0.5 0.3 mirMAP -0.27 4.0E-5 NA
49 hsa-miR-26b-5p CCND2 -0.3 0.16008 -0.5 0.3 mirMAP; miRNATAP -0.58 0.00034 NA
50 hsa-miR-301a-3p CCND2 1.45 1.0E-5 -0.5 0.3 miRNAWalker2 validate -0.38 0.0002 NA
51 hsa-miR-3065-3p CCND2 -1.04 0.02184 -0.5 0.3 MirTarget; miRNATAP -0.2 0.00685 NA
52 hsa-miR-3065-5p CCND2 -0.24 0.63312 -0.5 0.3 mirMAP -0.24 0.00057 NA
53 hsa-miR-424-5p CCND2 1.09 0.00042 -0.5 0.3 miRNATAP -0.39 0.0003 NA
54 hsa-miR-429 CCND2 1.4 0.009 -0.5 0.3 miRNATAP -0.19 0.002 NA
55 hsa-miR-450b-5p CCND2 0.46 0.13274 -0.5 0.3 MirTarget; PITA; miRNATAP -0.32 0.00413 NA
56 hsa-miR-590-3p CCND2 1.12 0.00016 -0.5 0.3 miRanda; mirMAP -0.33 0.00348 NA
57 hsa-miR-590-5p CCND2 1.04 0.00027 -0.5 0.3 mirMAP -0.41 0.00055 NA
58 hsa-miR-9-3p CCND2 0.33 0.54111 -0.5 0.3 MirTarget; mirMAP; miRNATAP -0.19 0.00361 NA
59 hsa-miR-93-5p CCND2 1.75 0 -0.5 0.3 miRNATAP -0.32 0.00244 NA
60 hsa-miR-96-5p CCND2 1.14 0.00943 -0.5 0.3 TargetScan; miRNATAP -0.33 3.0E-5 NA
61 hsa-miR-96-5p CCND3 1.14 0.00943 0.04 0.88352 TargetScan -0.12 0.00328 NA
62 hsa-miR-125b-5p CCNE1 -0.51 0.13327 2.19 0 miRNAWalker2 validate -0.26 0.00155 NA
63 hsa-miR-195-5p CCNE1 -0.91 0.00151 2.19 0 miRNAWalker2 validate; MirTarget; miRNATAP -0.43 1.0E-5 24402230 Furthermore through qPCR and western blot assays we showed that overexpression of miR-195-5p reduced CCNE1 mRNA and protein levels respectively
64 hsa-miR-497-5p CCNE1 -0.8 0.0036 2.19 0 MirTarget; miRNATAP -0.43 2.0E-5 24112607; 25909221; 24909281 Western blot assays confirmed that overexpression of miR-497 reduced cyclin E1 protein levels; Inhibited cellular growth suppressed cellular migration and invasion and G1 cell cycle arrest were observed upon overexpression of miR-497 in cells possibly by targeting cyclin E1;The effect of simultaneous overexpression of miR-497 and miR-34a on the inhibition of cell proliferation colony formation and tumor growth and the downregulation of cyclin E1 was stronger than the effect of each miRNA alone; The synergistic actions of miR-497 and miR-34a partly correlated with cyclin E1 levels; These results indicate cyclin E1 is downregulated by both miR-497 and miR-34a which synergistically retard the growth of human lung cancer cells;miR 497 suppresses proliferation of human cervical carcinoma HeLa cells by targeting cyclin E1; Furthermore the target effect of miR-497 on the CCNE1 was identified by dual-luciferase reporter assay system qRT-PCR and Western blotting; Over-expressed miR-497 in HeLa cells could suppress cell proliferation by targeting CCNE1
65 hsa-miR-26a-5p CCNE2 -0.38 0.04425 1.36 0 miRNAWalker2 validate; miRTarBase; miRNATAP -0.44 0.0001 24116110; 21901171 The loss of miR 26a mediated post transcriptional regulation of cyclin E2 in pancreatic cancer cell proliferation and decreased patient survival; The in vitro and in vivo assays showed that overexpression of miR-26a resulted in cell cycle arrest inhibited cell proliferation and decreased tumor growth which was associated with cyclin E2 downregulation;We also show that enforced expression of miR-26a in AML cells is able to inhibit cell cycle progression by downregulating cyclin E2 expression
66 hsa-miR-30a-5p CCNE2 -1.72 0 1.36 0 miRNATAP -0.22 0.00034 NA
67 hsa-miR-23b-3p CCNH -0.29 0.18665 -0.18 0.23096 MirTarget -0.18 0.00023 NA
68 hsa-let-7a-3p CDC14A 0.5 0.04111 -0.72 0.0057 mirMAP -0.25 0.00105 NA
69 hsa-let-7b-3p CDC14A 0.22 0.29604 -0.72 0.0057 mirMAP -0.4 1.0E-5 NA
70 hsa-let-7f-1-3p CDC14A 1.29 0 -0.72 0.0057 mirMAP -0.28 5.0E-5 NA
71 hsa-let-7a-3p CDC14B 0.5 0.04111 -0.81 0.00843 miRNATAP -0.37 3.0E-5 NA
72 hsa-let-7b-3p CDC14B 0.22 0.29604 -0.81 0.00843 miRNATAP -0.36 0.0007 NA
73 hsa-miR-193a-5p CDC14B 0.07 0.76855 -0.81 0.00843 miRNATAP -0.47 0 NA
74 hsa-miR-27a-3p CDC14B 1.3 0 -0.81 0.00843 miRNATAP -0.55 0 NA
75 hsa-miR-27b-3p CDC14B 0.08 0.72527 -0.81 0.00843 miRNATAP -0.4 1.0E-5 NA
76 hsa-miR-944 CDC14B 3.33 0.01778 -0.81 0.00843 PITA; mirMAP; miRNATAP -0.14 0 NA
77 hsa-miR-30a-5p CDC20 -1.72 0 3.92 0 miRNAWalker2 validate -0.48 0 NA
78 hsa-miR-29c-3p CDC23 -1.62 0 0.35 0.01053 miRNAWalker2 validate -0.14 0 NA
79 hsa-let-7c-5p CDC25A -0.5 0.20685 2.07 0 MirTarget -0.21 0.00039 25909324 MicroRNA let 7c Inhibits Cell Proliferation and Induces Cell Cycle Arrest by Targeting CDC25A in Human Hepatocellular Carcinoma; The aim of the present study was to determine whether the cell cycle regulator CDC25A is involved in the antitumor effect of let-7c in HCC; The luciferase reporter assay showed that CDC25A was a direct target of let-7c and that let-7c inhibited the expression of CDC25A protein by directly targeting its 3' UTR; In conclusion this study indicates that let-7c suppresses HCC progression possibly by directly targeting the cell cycle regulator CDC25A and indirectly affecting its downstream target molecules
80 hsa-miR-195-5p CDC25A -0.91 0.00151 2.07 0 MirTarget; miRNATAP -0.37 0 NA
81 hsa-miR-497-5p CDC25A -0.8 0.0036 2.07 0 MirTarget; miRNATAP -0.39 0 NA
82 hsa-miR-148a-3p CDC25B -1.54 4.0E-5 2.46 0 miRNAWalker2 validate; miRNATAP -0.19 0.00242 25341915 Gene CDC25B might be the target gene of miR-148a according to the results of targetscan; CDC25B may be the target gene of miR-148a that plays a role in tumor suppressor
83 hsa-miR-107 CDC27 0.9 5.0E-5 0.38 0.0058 miRanda; miRNATAP -0.15 0.00056 NA
84 hsa-miR-195-5p CDC27 -0.91 0.00151 0.38 0.0058 miRNATAP -0.22 0 NA
85 hsa-miR-32-5p CDC27 0.42 0.10646 0.38 0.0058 miRNAWalker2 validate -0.15 5.0E-5 NA
86 hsa-miR-326 CDC27 -0.43 0.26299 0.38 0.0058 miRanda -0.12 0 NA
87 hsa-miR-335-5p CDC27 1.6 6.0E-5 0.38 0.0058 miRNATAP -0.1 1.0E-5 NA
88 hsa-miR-497-5p CDC27 -0.8 0.0036 0.38 0.0058 miRNATAP -0.16 1.0E-5 NA
89 hsa-miR-338-5p CDC7 -1.2 0.01003 1.75 0 mirMAP -0.16 0.0001 NA
90 hsa-miR-145-5p CDK4 -1.75 2.0E-5 1.16 0 miRNAWalker2 validate; miRTarBase -0.13 0.00065 21092188 Furthermore we found that CDK4 was regulated by miR-145 in cell cycle control
91 hsa-miR-195-5p CDK4 -0.91 0.00151 1.16 0 miRNAWalker2 validate; miRTarBase -0.16 0.00344 NA
92 hsa-miR-101-3p CDK6 -0.45 0.02834 0.3 0.4008 mirMAP -0.39 0.00173 NA
93 hsa-miR-129-5p CDK6 -2.57 0 0.3 0.4008 miRNAWalker2 validate -0.13 0.00427 24055727 Interestingly we showed that cyclin dependent kinase 6 CDK6 a cell cycle-associated protein involved in G1-S transition was a target of miR-129
94 hsa-miR-30d-3p CDK6 -0.55 0.04337 0.3 0.4008 mirMAP -0.28 0.00298 NA
95 hsa-miR-30d-5p CDK6 -0.55 0.01401 0.3 0.4008 mirMAP -0.44 9.0E-5 NA
96 hsa-miR-139-5p CDK7 -1.83 0 0.5 0.00793 miRanda -0.13 0.00188 NA
97 hsa-miR-199a-5p CDK7 0.37 0.23266 0.5 0.00793 miRanda -0.13 0.00271 NA
98 hsa-let-7d-5p CDKN1A 0.98 0 -0.53 0.09948 MirTarget -0.4 0.00048 NA
99 hsa-let-7g-5p CDKN1A 0.33 0.24114 -0.53 0.09948 MirTarget -0.31 0.00013 NA
100 hsa-let-7i-5p CDKN1A 0.8 3.0E-5 -0.53 0.09948 MirTarget -0.32 0.00701 NA
101 hsa-miR-101-3p CDKN1A -0.45 0.02834 -0.53 0.09948 MirTarget -0.45 6.0E-5 NA
102 hsa-miR-106b-5p CDKN1A 1.71 0 -0.53 0.09948 miRNAWalker2 validate; miRTarBase; MirTarget; miRNATAP -0.32 1.0E-5 NA
103 hsa-miR-146a-5p CDKN1A 1.82 2.0E-5 -0.53 0.09948 miRNAWalker2 validate -0.18 0.00045 NA
104 hsa-miR-17-5p CDKN1A 1.66 0 -0.53 0.09948 miRNAWalker2 validate; miRTarBase; MirTarget; TargetScan; miRNATAP -0.26 0.00022 26482648; 24989082 The low expressions of miR-17 and miR-92 families can maintain cisplatin resistance through the regulation of CDKN1A and RAD21;According to PicTar and Miranda algorithms which predicted CDKN1A p21 as a putative target of miR-17 a luciferase assay was performed and revealed that miR-17 directly targets the 3'-UTR of p21 mRNA
105 hsa-miR-20a-5p CDKN1A 1.45 0 -0.53 0.09948 miRNAWalker2 validate; miRTarBase; MirTarget; miRNATAP -0.31 4.0E-5 26012475 Using the poorly tumorigenic and TGF-β-sensitive FET cell line that expresses low miR-20a levels we first confirmed that miR-20a downmodulated CDKN1A expression both at mRNA and protein level through direct binding to its 3'-UTR; Moreover besides modulating CDKN1A miR-20a blocked TGF-β-induced transactivation of its promoter without affecting the post-receptor activation of Smad3/4 effectors directly; Finally miR-20a abrogated the TGF-β-mediated c-Myc repression a direct inhibitor of the CDKN1A promoter activation most likely by reducing the expression of specific MYC-regulating genes from the Smad/E2F-based core repressor complex
106 hsa-miR-30b-3p CDKN1A -0.27 0.40085 -0.53 0.09948 MirTarget -0.23 0.00125 NA
107 hsa-miR-335-5p CDKN1A 1.6 6.0E-5 -0.53 0.09948 miRNAWalker2 validate -0.32 0 NA
108 hsa-miR-345-5p CDKN1A 1.84 0 -0.53 0.09948 miRNAWalker2 validate; miRTarBase; MirTarget -0.24 0.00033 NA
109 hsa-miR-423-3p CDKN1A 0.82 0.00026 -0.53 0.09948 miRNAWalker2 validate; miRTarBase -0.32 0.00138 NA
110 hsa-miR-423-5p CDKN1A 0.83 0.00079 -0.53 0.09948 MirTarget -0.41 0 NA
111 hsa-miR-429 CDKN1A 1.4 0.009 -0.53 0.09948 miRNATAP -0.13 0.00128 NA
112 hsa-miR-93-5p CDKN1A 1.75 0 -0.53 0.09948 miRNAWalker2 validate; miRTarBase; MirTarget; miRNATAP -0.32 1.0E-5 25633810 MicroRNA 93 activates c Met/PI3K/Akt pathway activity in hepatocellular carcinoma by directly inhibiting PTEN and CDKN1A; We confirmed that miR-93 directly bound with the 3' untranslated regions of the tumor-suppressor genes PTEN and CDKN1A respectivelyand inhibited their expression; We concluded that miR-93 stimulated cell proliferation migration and invasion through the oncogenic c-Met/PI3K/Akt pathway and also inhibited apoptosis by directly inhibiting PTEN and CDKN1A expression in human HCC
113 hsa-miR-942-5p CDKN1A 1.91 0 -0.53 0.09948 miRNAWalker2 validate -0.18 0.00704 NA
114 hsa-miR-24-3p CDKN1B 1.09 0 0.16 0.36377 miRNAWalker2 validate; miRNATAP -0.15 0.00772 26847530; 26044523 The biological significance of miR-24 expression in prostate cancer cells was assessed by a series of in vitro bioassays and the effect on proposed targets p27 CDKN1B and p16 CDK2NA was investigated;With the bioinformatic method we further identified that p27Kip1 is a direct target of miR-24-3p and its protein level was negatively regulated by miR-24-3p
115 hsa-miR-221-3p CDKN1C 1.33 0 -1.65 3.0E-5 miRNAWalker2 validate; miRTarBase; miRNATAP -0.32 0.00244 20461750 miR-221 and miR-222 negatively regulate expression of CDKN1B p27 and CDKN1C p57 two cell cycle regulators expressed in ovarian surface epithelium and down-regulated in ovarian carcinomas; Higher miR-222 and miR-221 expression were significantly associated with decreased CDKN1C expression P = 0.009 and 0.01
116 hsa-miR-222-3p CDKN1C 1.39 0 -1.65 3.0E-5 miRNAWalker2 validate; miRTarBase; miRNATAP -0.37 0.00017 20461750 miR-221 and miR-222 negatively regulate expression of CDKN1B p27 and CDKN1C p57 two cell cycle regulators expressed in ovarian surface epithelium and down-regulated in ovarian carcinomas; Higher miR-222 and miR-221 expression were significantly associated with decreased CDKN1C expression P = 0.009 and 0.01
117 hsa-miR-92a-3p CDKN1C 1.22 1.0E-5 -1.65 3.0E-5 MirTarget; miRNATAP -0.27 0.01 NA
118 hsa-miR-125b-5p CDKN2A -0.51 0.13327 1.06 0.26133 miRNAWalker2 validate -0.58 0.00347 23585871 In this study we further extend our studies by showing that miR-125b represses the protein product of the ink4a/ARF locus p14ARF in two prostate cancer cell lines LNCaP wild type-p53 and 22Rv1 both wild type and mutant p53 as well as in the PC-346C prostate cancer xenograft model that lentivirally overexpressed miR-125b; Conversely treatment of prostate cancer cells with an inhibitor of miR-125b anti-miR-125b resulted in increased expression of p14ARF decreased level of Mdm2 and induction of apoptosis; In addition overexpression of miR-125b in p53-deficient PC3 cells induced down-regulation of p14ARF which leads to increased cell proliferation through a p53-independent manner
119 hsa-miR-365a-3p CDKN2A -0.89 0.00255 1.06 0.26133 MirTarget -0.76 0.00074 NA
120 hsa-miR-9-3p CDKN2B 0.33 0.54111 -0.03 0.96549 mirMAP -0.29 0.00089 NA
121 hsa-miR-192-5p CDKN2D 0.08 0.94106 0.86 0.00075 miRNAWalker2 validate -0.11 0 NA
122 hsa-miR-362-3p CDKN2D -0.03 0.91378 0.86 0.00075 MirTarget; PITA; miRanda; miRNATAP -0.16 0.00453 NA
123 hsa-miR-129-5p CHEK1 -2.57 0 2.16 0 miRanda -0.14 0.00016 NA
124 hsa-miR-139-5p CHEK1 -1.83 0 2.16 0 miRanda -0.39 0 NA
125 hsa-miR-195-5p CHEK1 -0.91 0.00151 2.16 0 MirTarget; miRNATAP -0.34 0 25840419 MiR 195 suppresses non small cell lung cancer by targeting CHEK1; We discovered that CHEK1 was a direct target of miR-195 which decreased CHEK1 expression in lung cancer cells
126 hsa-miR-497-5p CHEK1 -0.8 0.0036 2.16 0 MirTarget; miRNATAP -0.35 0 24464213 Checkpoint kinase 1 is negatively regulated by miR 497 in hepatocellular carcinoma; In silico analysis showed that CHEK1 was a candidate target of miR-497 which was previously found to be downregulated in HCC by us; To test whether miR-497 could bind to 3'untranslated region 3'UTR of CHEK1 luciferase reporter assay was conducted; The result revealed that miR-497 could bind to the 3'untranslated region 3'UTR of CHEK1 mRNA; Western blot showed that ectopic expression of miR-497 suppressed the CHEK1 expression and inhibition of miR-497 led to significant upregulation of CHEK1; Finally miR-497 expression was measured in the same 30 HCC samples and the correlation between miR-497 and CHEK1 was analyzed; The results indicated that miR-497 was downregulated in HCC and had a significant negative correlation with CHEK1; Taken together these results demonstrated that CHEK1 was negatively regulated by miR-497 and the overexpressed CHEK1 was resulted from the downregulated miR-497 in HCC which provided a potential molecular target for HCC therapy
127 hsa-miR-186-5p CREBBP 0.15 0.43471 -0.11 0.45436 mirMAP; miRNATAP -0.14 0.00768 NA
128 hsa-miR-195-3p DBF4 -1.35 2.0E-5 1.68 0 mirMAP -0.23 8.0E-5 NA
129 hsa-miR-30a-5p DBF4 -1.72 0 1.68 0 MirTarget -0.17 0.00221 NA
130 hsa-miR-10a-5p E2F1 -0.47 0.1488 1.94 0 miRNAWalker2 validate -0.16 0.00697 NA
131 hsa-miR-125a-5p E2F2 -0.88 0.00021 2.79 0 MirTarget -0.4 0.00032 NA
132 hsa-miR-125b-5p E2F2 -0.51 0.13327 2.79 0 miRNAWalker2 validate; miRTarBase; MirTarget; miRNATAP -0.22 0.00603 22999819 miR 125b regulates the proliferation of glioblastoma stem cells by targeting E2F2; This study demonstrated that miR-125b plays important roles in regulating the proliferation of GSCs by directly targeting E2F2
133 hsa-miR-101-3p E2F3 -0.45 0.02834 1.26 0 miRNAWalker2 validate -0.24 0.00078 NA
134 hsa-miR-10a-5p E2F3 -0.47 0.1488 1.26 0 miRNATAP -0.12 0.00663 NA
135 hsa-miR-145-5p E2F3 -1.75 2.0E-5 1.26 0 miRNATAP -0.14 3.0E-5 25762621 miR 145 mediates the antiproliferative and gene regulatory effects of vitamin D3 by directly targeting E2F3 in gastric cancer cells; Furthermore miR-145 expression was lower in tumors compared with matched normal samples and correlated with increased the E2F3 transcription factor protein staining
136 hsa-miR-195-5p E2F3 -0.91 0.00151 1.26 0 miRNAWalker2 validate; miRTarBase; miRNATAP -0.23 0 22217655 We identified E2F3 and CCND3 as functional downstream targets of miR-195 in glioblastoma cells
137 hsa-miR-497-5p E2F3 -0.8 0.0036 1.26 0 miRNATAP -0.18 0.00065 NA
138 hsa-let-7a-2-3p E2F5 0.2 0.64356 0.53 0.22286 MirTarget -0.24 0.00118 NA
139 hsa-let-7b-5p E2F5 0.06 0.7814 0.53 0.22286 miRNAWalker2 validate; MirTarget; miRNATAP -0.71 0 NA
140 hsa-let-7c-5p E2F5 -0.5 0.20685 0.53 0.22286 MirTarget -0.22 0.00545 NA
141 hsa-miR-1-3p E2F5 -2.66 2.0E-5 0.53 0.22286 MirTarget -0.13 0.00626 NA
142 hsa-miR-1271-5p E2F5 1.16 0.00208 0.53 0.22286 MirTarget -0.27 0.00093 NA
143 hsa-miR-199a-5p E2F5 0.37 0.23266 0.53 0.22286 miRanda -0.37 0.00018 NA
144 hsa-miR-199b-5p E2F5 0.12 0.67816 0.53 0.22286 miRanda -0.28 0.00597 NA
145 hsa-miR-205-5p E2F5 3.14 0.02932 0.53 0.22286 miRNAWalker2 validate; miRTarBase; miRNATAP -0.16 0 21454583 The expression levels of E2F1 and E2F5 were correlated inversely with that of miR-205 in melanoma cell lines; miR-205 significantly suppressed the luciferase activity of reporter plasmids containing the 3'-UTR sequences complementary to either E2F1 or E2F5; Overexpression of miR-205 in melanoma cells reduced E2F1 and E2F5 protein levels
146 hsa-miR-337-3p E2F5 -0.72 0.03374 0.53 0.22286 MirTarget; PITA -0.31 0.00051 NA
147 hsa-miR-34c-5p E2F5 2.21 0.00038 0.53 0.22286 MirTarget; PITA; miRanda; miRNATAP -0.28 0 NA
148 hsa-miR-106b-5p EP300 1.71 0 0.03 0.83304 miRNATAP -0.1 0.00164 NA
149 hsa-miR-212-3p EP300 0.96 0.00133 0.03 0.83304 MirTarget; miRNATAP -0.12 0.00033 NA
150 hsa-miR-26a-5p EP300 -0.38 0.04425 0.03 0.83304 miRNATAP -0.19 0.00038 NA

Over-represented Gene Ontology Biological Process

NumGOOverlapSizeP ValueAdj. P Value
1 CELL CYCLE 69 1316 1.025e-68 4.768e-65
2 CELL CYCLE PROCESS 64 1081 3.025e-65 7.038e-62
3 REGULATION OF CELL CYCLE 61 949 1.944e-63 3.015e-60
4 MITOTIC CELL CYCLE 57 766 6.94e-62 8.073e-59
5 REGULATION OF MITOTIC CELL CYCLE 42 468 8.984e-47 8.361e-44
6 REGULATION OF CELL CYCLE PHASE TRANSITION 36 321 4.087e-43 2.717e-40
7 NEGATIVE REGULATION OF CELL CYCLE 39 433 3.596e-43 2.717e-40
8 CELL CYCLE PHASE TRANSITION 33 255 1.89e-41 1.099e-38
9 REGULATION OF CELL CYCLE PROCESS 40 558 2.338e-40 1.209e-37
10 CELL CYCLE CHECKPOINT 29 194 3.828e-38 1.781e-35
11 NEGATIVE REGULATION OF MITOTIC CELL CYCLE 27 199 3.043e-34 1.287e-31
12 REGULATION OF PROTEIN MODIFICATION PROCESS 51 1710 4.535e-34 1.758e-31
13 REGULATION OF TRANSFERASE ACTIVITY 42 946 6.208e-34 2.222e-31
14 NEGATIVE REGULATION OF CELL CYCLE PROCESS 27 214 2.381e-33 7.914e-31
15 MITOTIC CELL CYCLE CHECKPOINT 24 139 4.694e-33 1.456e-30
16 CELL DIVISION 33 460 8.818e-33 2.564e-30
17 POSITIVE REGULATION OF CELL CYCLE 29 332 4.02e-31 1.1e-28
18 CELL CYCLE G1 S PHASE TRANSITION 21 111 8.056e-30 1.973e-27
19 G1 S TRANSITION OF MITOTIC CELL CYCLE 21 111 8.056e-30 1.973e-27
20 NEGATIVE REGULATION OF CELL CYCLE PHASE TRANSITION 22 146 6.688e-29 1.556e-26
21 POSITIVE REGULATION OF CELL CYCLE PROCESS 24 247 8.832e-27 1.957e-24
22 DNA INTEGRITY CHECKPOINT 20 146 2.037e-25 4.309e-23
23 NEGATIVE REGULATION OF PROTEIN METABOLIC PROCESS 37 1087 2.402e-25 4.859e-23
24 NEGATIVE REGULATION OF PROTEIN MODIFICATION PROCESS 30 616 1.122e-24 2.176e-22
25 REGULATION OF PHOSPHORUS METABOLIC PROCESS 42 1618 1.389e-24 2.585e-22
26 POSITIVE REGULATION OF PROTEIN METABOLIC PROCESS 40 1492 9.383e-24 1.679e-21
27 REGULATION OF KINASE ACTIVITY 31 776 5.701e-23 9.825e-21
28 MITOTIC NUCLEAR DIVISION 24 361 8.386e-23 1.394e-20
29 POSITIVE REGULATION OF PROTEIN MODIFICATION PROCESS 35 1135 1.986e-22 3.187e-20
30 REGULATION OF ORGANELLE ORGANIZATION 35 1178 6.708e-22 1.04e-19
31 REGULATION OF CYCLIN DEPENDENT PROTEIN KINASE ACTIVITY 16 97 8.259e-22 1.24e-19
32 NEGATIVE REGULATION OF CELL CYCLE G1 S PHASE TRANSITION 16 98 9.839e-22 1.431e-19
33 CELLULAR RESPONSE TO DNA DAMAGE STIMULUS 29 720 1.621e-21 2.285e-19
34 REGULATION OF CELL DIVISION 21 272 2.56e-21 3.503e-19
35 REGULATION OF CELL CYCLE ARREST 16 108 5.122e-21 6.809e-19
36 ORGANELLE FISSION 25 496 8.155e-21 1.054e-18
37 REGULATION OF CELL CYCLE G1 S PHASE TRANSITION 17 147 2.226e-20 2.8e-18
38 NEGATIVE REGULATION OF TRANSFERASE ACTIVITY 22 351 2.396e-20 2.933e-18
39 G1 DNA DAMAGE CHECKPOINT 14 73 3.601e-20 4.296e-18
40 SIGNAL TRANSDUCTION IN RESPONSE TO DNA DAMAGE 15 96 4.052e-20 4.714e-18
41 REGULATION OF PROTEIN SERINE THREONINE KINASE ACTIVITY 24 470 4.163e-20 4.725e-18
42 CELL CYCLE ARREST 17 154 5.028e-20 5.57e-18
43 MITOTIC DNA INTEGRITY CHECKPOINT 15 100 7.749e-20 8.385e-18
44 POSITIVE REGULATION OF TRANSFERASE ACTIVITY 26 616 9.877e-20 1.044e-17
45 REGULATION OF NUCLEAR DIVISION 17 163 1.353e-19 1.399e-17
46 REGULATION OF CELL PROLIFERATION 36 1496 1.519e-19 1.536e-17
47 REGULATION OF PROTEIN CATABOLIC PROCESS 22 393 2.74e-19 2.713e-17
48 POSITIVE REGULATION OF CELL CYCLE ARREST 14 85 3.562e-19 3.453e-17
49 POSITIVE REGULATION OF PROTEOLYSIS 21 363 1.027e-18 9.749e-17
50 CHROMOSOME ORGANIZATION 30 1009 1.43e-18 1.331e-16
51 REGULATION OF CELLULAR PROTEIN CATABOLIC PROCESS 19 274 1.927e-18 1.758e-16
52 REGULATION OF PROTEOLYSIS 26 711 3.395e-18 3.037e-16
53 CELL CYCLE G2 M PHASE TRANSITION 15 138 1.181e-17 1.037e-15
54 POSITIVE REGULATION OF CELL DEATH 24 605 1.388e-17 1.196e-15
55 REGULATION OF SISTER CHROMATID SEGREGATION 12 67 4.878e-17 4.127e-15
56 CELLULAR RESPONSE TO STRESS 34 1565 5.42e-17 4.503e-15
57 REGULATION OF CHROMOSOME ORGANIZATION 18 278 5.699e-17 4.652e-15
58 REGULATION OF CELL DEATH 33 1472 7.471e-17 5.994e-15
59 POSITIVE REGULATION OF MITOTIC CELL CYCLE 14 123 8.013e-17 6.32e-15
60 NEGATIVE REGULATION OF CATALYTIC ACTIVITY 26 829 1.413e-16 1.096e-14
61 REGULATION OF LIGASE ACTIVITY 14 130 1.775e-16 1.354e-14
62 POSITIVE REGULATION OF CATALYTIC ACTIVITY 33 1518 1.854e-16 1.391e-14
63 NEGATIVE REGULATION OF PHOSPHORUS METABOLIC PROCESS 22 541 2.372e-16 1.712e-14
64 RESPONSE TO ABIOTIC STIMULUS 28 1024 2.392e-16 1.712e-14
65 NEGATIVE REGULATION OF PHOSPHATE METABOLIC PROCESS 22 541 2.372e-16 1.712e-14
66 POSITIVE REGULATION OF BIOSYNTHETIC PROCESS 35 1805 5.262e-16 3.71e-14
67 NEGATIVE REGULATION OF MOLECULAR FUNCTION 28 1079 9.075e-16 6.302e-14
68 REGULATION OF CATABOLIC PROCESS 24 731 9.823e-16 6.722e-14
69 POSITIVE REGULATION OF CELL PROLIFERATION 25 814 1.012e-15 6.727e-14
70 REGULATION OF CHROMOSOME SEGREGATION 12 85 1.009e-15 6.727e-14
71 POSITIVE REGULATION OF GENE EXPRESSION 34 1733 1.176e-15 7.709e-14
72 POSITIVE REGULATION OF CELLULAR PROTEIN CATABOLIC PROCESS 15 192 1.772e-15 1.145e-13
73 POSITIVE REGULATION OF MOLECULAR FUNCTION 34 1791 3.142e-15 1.979e-13
74 PROTEIN PHOSPHORYLATION 26 944 3.147e-15 1.979e-13
75 SIGNAL TRANSDUCTION BY P53 CLASS MEDIATOR 13 127 4.488e-15 2.784e-13
76 POSITIVE REGULATION OF CELLULAR PROTEIN LOCALIZATION 18 360 5.29e-15 3.239e-13
77 NEGATIVE REGULATION OF PHOSPHORYLATION 19 422 5.648e-15 3.413e-13
78 RESPONSE TO OXYGEN LEVELS 17 311 7.649e-15 4.563e-13
79 POSITIVE REGULATION OF PROTEIN CATABOLIC PROCESS 16 263 9.735e-15 5.734e-13
80 REGULATION OF PROTEIN UBIQUITINATION INVOLVED IN UBIQUITIN DEPENDENT PROTEIN CATABOLIC PROCESS 12 103 1.107e-14 6.437e-13
81 SISTER CHROMATID SEGREGATION 14 176 1.294e-14 7.435e-13
82 ANAPHASE PROMOTING COMPLEX DEPENDENT CATABOLIC PROCESS 11 77 1.474e-14 8.365e-13
83 CHROMOSOME SEGREGATION 16 272 1.647e-14 9.233e-13
84 NUCLEAR CHROMOSOME SEGREGATION 15 228 2.279e-14 1.263e-12
85 DNA METABOLIC PROCESS 23 758 2.35e-14 1.286e-12
86 POSITIVE REGULATION OF LIGASE ACTIVITY 12 110 2.488e-14 1.346e-12
87 POSITIVE REGULATION OF PROTEIN MODIFICATION BY SMALL PROTEIN CONJUGATION OR REMOVAL 14 196 5.791e-14 3.097e-12
88 REGULATION OF CELLULAR PROTEIN LOCALIZATION 20 552 5.925e-14 3.133e-12
89 POSITIVE REGULATION OF ORGANELLE ORGANIZATION 20 573 1.189e-13 6.214e-12
90 REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 32 1784 1.4e-13 7.238e-12
91 POSITIVE REGULATION OF CELL CYCLE PHASE TRANSITION 10 68 1.826e-13 9.338e-12
92 PROTEIN UBIQUITINATION INVOLVED IN UBIQUITIN DEPENDENT PROTEIN CATABOLIC PROCESS 12 134 2.757e-13 1.395e-11
93 POSITIVE REGULATION OF CELLULAR COMPONENT ORGANIZATION 26 1152 3.297e-13 1.65e-11
94 REGULATION OF PROTEIN MODIFICATION BY SMALL PROTEIN CONJUGATION OR REMOVAL 15 280 4.604e-13 2.279e-11
95 POSITIVE REGULATION OF FIBROBLAST PROLIFERATION 9 53 7.977e-13 3.907e-11
96 REGULATION OF PROTEASOMAL UBIQUITIN DEPENDENT PROTEIN CATABOLIC PROCESS 12 148 9.12e-13 4.421e-11
97 CELL DEATH 24 1001 9.421e-13 4.519e-11
98 POSITIVE REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 24 1004 1.004e-12 4.768e-11
99 PHOSPHORYLATION 26 1228 1.423e-12 6.688e-11
100 INTRACELLULAR SIGNAL TRANSDUCTION 29 1572 1.508e-12 7.019e-11
101 POSITIVE REGULATION OF MITOCHONDRIAL OUTER MEMBRANE PERMEABILIZATION INVOLVED IN APOPTOTIC SIGNALING PATHWAY 8 36 1.551e-12 7.146e-11
102 NEGATIVE REGULATION OF KINASE ACTIVITY 14 250 1.632e-12 7.443e-11
103 RESPONSE TO UV 11 126 3.819e-12 1.709e-10
104 NEGATIVE REGULATION OF PROTEIN SERINE THREONINE KINASE ACTIVITY 11 126 3.819e-12 1.709e-10
105 PROTEASOMAL PROTEIN CATABOLIC PROCESS 14 271 4.858e-12 2.153e-10
106 POSITIVE REGULATION OF CATABOLIC PROCESS 16 395 5.042e-12 2.213e-10
107 CELLULAR RESPONSE TO UV 9 66 6.384e-12 2.776e-10
108 POSITIVE REGULATION OF RESPONSE TO STIMULUS 31 1929 7.137e-12 3.075e-10
109 REGULATION OF MITOCHONDRIAL OUTER MEMBRANE PERMEABILIZATION INVOLVED IN APOPTOTIC SIGNALING PATHWAY 8 43 7.263e-12 3.101e-10
110 DNA REPAIR 17 480 8.465e-12 3.581e-10
111 CELLULAR RESPONSE TO RADIATION 11 137 9.601e-12 4.024e-10
112 RESPONSE TO RADIATION 16 413 9.85e-12 4.071e-10
113 NEGATIVE REGULATION OF CELL PROLIFERATION 19 643 9.887e-12 4.071e-10
114 REGULATION OF PROTEASOMAL PROTEIN CATABOLIC PROCESS 12 181 9.988e-12 4.077e-10
115 NEGATIVE REGULATION OF PROTEIN MODIFICATION BY SMALL PROTEIN CONJUGATION OR REMOVAL 11 139 1.125e-11 4.554e-10
116 POSITIVE REGULATION OF PHOSPHATE METABOLIC PROCESS 23 1036 1.5e-11 5.966e-10
117 POSITIVE REGULATION OF PHOSPHORUS METABOLIC PROCESS 23 1036 1.5e-11 5.966e-10
118 NEGATIVE REGULATION OF CHROMOSOME SEGREGATION 7 28 1.656e-11 6.53e-10
119 REGULATION OF PROTEIN INSERTION INTO MITOCHONDRIAL MEMBRANE INVOLVED IN APOPTOTIC SIGNALING PATHWAY 7 29 2.176e-11 8.436e-10
120 POSITIVE REGULATION OF PROTEIN INSERTION INTO MITOCHONDRIAL MEMBRANE INVOLVED IN APOPTOTIC SIGNALING PATHWAY 7 29 2.176e-11 8.436e-10
121 POSITIVE REGULATION OF INTRACELLULAR TRANSPORT 15 370 2.485e-11 9.555e-10
122 POSITIVE REGULATION OF STEM CELL DIFFERENTIATION 8 50 2.628e-11 1.002e-09
123 SISTER CHROMATID COHESION 10 111 2.811e-11 1.063e-09
124 POSITIVE REGULATION OF CELL COMMUNICATION 27 1532 3.306e-11 1.241e-09
125 REGULATION OF CELLULAR RESPONSE TO STRESS 19 691 3.413e-11 1.271e-09
126 REGULATION OF FIBROBLAST PROLIFERATION 9 81 4.282e-11 1.581e-09
127 RESPONSE TO LIPID 21 888 4.367e-11 1.6e-09
128 POSITIVE REGULATION OF EPITHELIAL TO MESENCHYMAL TRANSITION 7 34 7.377e-11 2.661e-09
129 NEGATIVE REGULATION OF MITOTIC NUCLEAR DIVISION 7 34 7.377e-11 2.661e-09
130 NEGATIVE REGULATION OF CELL DIVISION 8 60 1.212e-10 4.337e-09
131 CELLULAR RESPONSE TO LIGHT STIMULUS 9 91 1.245e-10 4.388e-09
132 MITOTIC SISTER CHROMATID SEGREGATION 9 91 1.245e-10 4.388e-09
133 PEPTIDYL AMINO ACID MODIFICATION 20 841 1.26e-10 4.408e-09
134 REGULATION OF PROTEIN LOCALIZATION 21 950 1.517e-10 5.267e-09
135 NEGATIVE REGULATION OF NITROGEN COMPOUND METABOLIC PROCESS 26 1517 1.589e-10 5.478e-09
136 PROTEIN MODIFICATION BY SMALL PROTEIN CONJUGATION OR REMOVAL 20 873 2.431e-10 8.319e-09
137 POSITIVE REGULATION OF ESTABLISHMENT OF PROTEIN LOCALIZATION 16 514 2.513e-10 8.537e-09
138 PHOSPHATE CONTAINING COMPOUND METABOLIC PROCESS 29 1977 3.968e-10 1.338e-08
139 REGULATION OF MEMBRANE PERMEABILITY 8 70 4.326e-10 1.448e-08
140 REGULATION OF INTRACELLULAR TRANSPORT 17 621 4.628e-10 1.538e-08
141 DIGESTIVE SYSTEM DEVELOPMENT 10 148 4.918e-10 1.623e-08
142 POSITIVE REGULATION OF CHROMOSOME ORGANIZATION 10 150 5.611e-10 1.839e-08
143 RESPONSE TO ORGANIC CYCLIC COMPOUND 20 917 5.741e-10 1.868e-08
144 NEGATIVE REGULATION OF PROTEIN CATABOLIC PROCESS 9 109 6.382e-10 2.062e-08
145 SPINDLE CHECKPOINT 6 25 6.562e-10 2.106e-08
146 NEGATIVE REGULATION OF NUCLEAR DIVISION 7 46 7.056e-10 2.249e-08
147 CELLULAR RESPONSE TO ABIOTIC STIMULUS 12 263 7.622e-10 2.413e-08
148 REPLICATIVE SENESCENCE 5 12 7.927e-10 2.492e-08
149 DNA REPLICATION 11 208 8.676e-10 2.709e-08
150 REGULATION OF DNA METABOLIC PROCESS 13 340 1.224e-09 3.798e-08
151 PROTEIN CATABOLIC PROCESS 16 579 1.412e-09 4.35e-08
152 CELL PROLIFERATION 17 672 1.534e-09 4.695e-08
153 POSITIVE REGULATION OF APOPTOTIC SIGNALING PATHWAY 10 171 2.017e-09 6.135e-08
154 RESPONSE TO DRUG 14 431 2.187e-09 6.608e-08
155 ACTIVATION OF ANAPHASE PROMOTING COMPLEX ACTIVITY 5 15 2.977e-09 8.937e-08
156 NEGATIVE REGULATION OF GENE EXPRESSION 24 1493 3.563e-09 1.063e-07
157 MITOCHONDRIAL MEMBRANE ORGANIZATION 8 92 3.967e-09 1.176e-07
158 G2 DNA DAMAGE CHECKPOINT 6 33 3.998e-09 1.177e-07
159 REGULATION OF CELL CYCLE G2 M PHASE TRANSITION 7 59 4.309e-09 1.261e-07
160 CELLULAR RESPONSE TO ORGANIC CYCLIC COMPOUND 14 465 5.765e-09 1.676e-07
161 POSITIVE REGULATION OF CYCLIN DEPENDENT PROTEIN KINASE ACTIVITY 6 36 6.963e-09 2.012e-07
162 NEGATIVE REGULATION OF CELLULAR PROTEIN CATABOLIC PROCESS 7 64 7.719e-09 2.205e-07
163 POSITIVE REGULATION OF TRANSMEMBRANE RECEPTOR PROTEIN SERINE THREONINE KINASE SIGNALING PATHWAY 8 100 7.724e-09 2.205e-07
164 REGULATION OF RESPONSE TO DNA DAMAGE STIMULUS 9 145 8.057e-09 2.286e-07
165 POSITIVE REGULATION OF KINASE ACTIVITY 14 482 9.085e-09 2.562e-07
166 REGULATION OF EPITHELIAL TO MESENCHYMAL TRANSITION 7 67 1.07e-08 2.999e-07
167 NEGATIVE REGULATION OF CELL DEATH 18 872 1.145e-08 3.19e-07
168 REGULATION OF TRANSMEMBRANE RECEPTOR PROTEIN SERINE THREONINE KINASE SIGNALING PATHWAY 10 207 1.27e-08 3.516e-07
169 RESPONSE TO STEROID HORMONE 14 497 1.337e-08 3.681e-07
170 RESPONSE TO LIGHT STIMULUS 11 280 1.933e-08 5.291e-07
171 REGULATION OF STEM CELL DIFFERENTIATION 8 113 2.035e-08 5.537e-07
172 REGULATION OF PROTEIN LOCALIZATION TO NUCLEUS 10 218 2.078e-08 5.623e-07
173 POSITIVE REGULATION OF CELL MORPHOGENESIS INVOLVED IN DIFFERENTIATION 9 162 2.123e-08 5.71e-07
174 REGULATION OF BINDING 11 283 2.157e-08 5.768e-07
175 APOPTOTIC SIGNALING PATHWAY 11 289 2.675e-08 7.112e-07
176 RESPONSE TO ALCOHOL 12 362 2.738e-08 7.238e-07
177 REGULATION OF CELLULAR LOCALIZATION 21 1277 2.951e-08 7.757e-07
178 PROTEIN UBIQUITINATION 15 629 3.499e-08 9.146e-07
179 RHYTHMIC PROCESS 11 298 3.661e-08 9.516e-07
180 NEGATIVE REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 16 740 4.486e-08 1.16e-06
181 POSITIVE REGULATION OF CHROMOSOME SEGREGATION 5 25 5.1e-08 1.311e-06
182 RESPONSE TO ENDOGENOUS STIMULUS 22 1450 5.367e-08 1.372e-06
183 REGULATION OF ESTABLISHMENT OF PROTEIN LOCALIZATION TO MITOCHONDRION 8 128 5.411e-08 1.376e-06
184 POSITIVE REGULATION OF PROTEIN LOCALIZATION TO NUCLEUS 8 129 5.75e-08 1.454e-06
185 REGULATION OF MICROTUBULE BASED PROCESS 10 243 5.794e-08 1.457e-06
186 RESPONSE TO GROWTH FACTOR 13 475 6.52e-08 1.631e-06
187 REGULATION OF RESPONSE TO STRESS 22 1468 6.677e-08 1.661e-06
188 POSITIVE REGULATION OF CELL DIVISION 8 132 6.878e-08 1.702e-06
189 MEIOTIC CELL CYCLE 9 186 7.005e-08 1.725e-06
190 PROTEIN K11 LINKED UBIQUITINATION 5 27 7.7e-08 1.876e-06
191 REGULATION OF TRANSCRIPTION INVOLVED IN G1 S TRANSITION OF MITOTIC CELL CYCLE 5 27 7.7e-08 1.876e-06
192 NEGATIVE REGULATION OF PROTEOLYSIS 11 329 9.997e-08 2.423e-06
193 CELLULAR RESPONSE TO ENDOGENOUS STIMULUS 18 1008 1.038e-07 2.503e-06
194 NEGATIVE REGULATION OF CELLULAR COMPONENT ORGANIZATION 15 684 1.045e-07 2.506e-06
195 SMAD PROTEIN SIGNAL TRANSDUCTION 6 56 1.087e-07 2.595e-06
196 DNA REPLICATION INITIATION 5 29 1.126e-07 2.672e-06
197 REGULATION OF CYTOSKELETON ORGANIZATION 13 502 1.236e-07 2.92e-06
198 NEGATIVE REGULATION OF CHROMOSOME ORGANIZATION 7 96 1.333e-07 3.133e-06
199 NEGATIVE REGULATION OF CATABOLIC PROCESS 9 203 1.48e-07 3.46e-06
200 REGULATION OF TRANSFORMING GROWTH FACTOR BETA RECEPTOR SIGNALING PATHWAY 7 99 1.649e-07 3.817e-06
201 REGULATION OF CELLULAR RESPONSE TO TRANSFORMING GROWTH FACTOR BETA STIMULUS 7 99 1.649e-07 3.817e-06
202 MACROMOLECULE CATABOLIC PROCESS 17 926 1.69e-07 3.894e-06
203 MITOTIC CELL CYCLE ARREST 4 13 1.824e-07 4.182e-06
204 NEGATIVE REGULATION OF CYCLIN DEPENDENT PROTEIN KINASE ACTIVITY 5 32 1.89e-07 4.311e-06
205 INTRINSIC APOPTOTIC SIGNALING PATHWAY 8 152 2.049e-07 4.651e-06
206 REGULATION OF CELL AGING 5 33 2.221e-07 5.016e-06
207 POSITIVE REGULATION OF MITOTIC SISTER CHROMATID SEPARATION 4 14 2.546e-07 5.662e-06
208 POSITIVE REGULATION OF MITOTIC METAPHASE ANAPHASE TRANSITION 4 14 2.546e-07 5.662e-06
209 REGULATION OF EPITHELIAL CELL PROLIFERATION 10 285 2.555e-07 5.662e-06
210 POSITIVE REGULATION OF METAPHASE ANAPHASE TRANSITION OF CELL CYCLE 4 14 2.546e-07 5.662e-06
211 REGULATION OF APOPTOTIC SIGNALING PATHWAY 11 363 2.68e-07 5.91e-06
212 REGULATION OF MITOCHONDRION ORGANIZATION 9 218 2.709e-07 5.917e-06
213 RESPONSE TO ESTROGEN 9 218 2.709e-07 5.917e-06
214 CHROMATIN MODIFICATION 13 539 2.793e-07 6.072e-06
215 POSITIVE REGULATION OF PROTEIN SERINE THREONINE KINASE ACTIVITY 10 289 2.905e-07 6.288e-06
216 REGULATION OF NUCLEOCYTOPLASMIC TRANSPORT 9 220 2.926e-07 6.303e-06
217 PROTEOLYSIS 19 1208 3.092e-07 6.631e-06
218 REGULATION OF DNA REPLICATION 8 161 3.185e-07 6.799e-06
219 REGULATION OF SIGNAL TRANSDUCTION BY P53 CLASS MEDIATOR 8 162 3.34e-07 7.096e-06
220 POSITIVE REGULATION OF MITOCHONDRION ORGANIZATION 8 167 4.212e-07 8.909e-06
221 NEGATIVE REGULATION OF EPITHELIAL CELL PROLIFERATION 7 115 4.604e-07 9.567e-06
222 INTRINSIC APOPTOTIC SIGNALING PATHWAY IN RESPONSE TO DNA DAMAGE 6 71 4.568e-07 9.567e-06
223 PROTEIN SUMOYLATION 7 115 4.604e-07 9.567e-06
224 CHROMATIN ORGANIZATION 14 663 4.626e-07 9.567e-06
225 MESENCHYME MORPHOGENESIS 5 38 4.622e-07 9.567e-06
226 NEGATIVE REGULATION OF CELL GROWTH 8 170 4.824e-07 9.932e-06
227 NEGATIVE REGULATION OF ORGANELLE ORGANIZATION 11 387 5.057e-07 1.037e-05
228 RESPONSE TO OXYGEN CONTAINING COMPOUND 20 1381 5.27e-07 1.075e-05
229 REGULATION OF CELL GROWTH 11 391 5.597e-07 1.137e-05
230 RESPONSE TO HORMONE 16 893 5.718e-07 1.157e-05
231 NEGATIVE REGULATION OF CELL AGING 4 17 5.997e-07 1.208e-05
232 GLAND DEVELOPMENT 11 395 6.187e-07 1.241e-05
233 MITOCHONDRIAL TRANSPORT 8 177 6.554e-07 1.298e-05
234 POSITIVE REGULATION OF NUCLEOCYTOPLASMIC TRANSPORT 7 121 6.505e-07 1.298e-05
235 POSITIVE REGULATION OF DEVELOPMENTAL PROCESS 18 1142 6.543e-07 1.298e-05
236 PROTEIN POLYUBIQUITINATION 9 243 6.743e-07 1.329e-05
237 REGULATION OF CELLULAR RESPONSE TO HEAT 6 76 6.86e-07 1.341e-05
238 REGULATION OF MICROTUBULE POLYMERIZATION OR DEPOLYMERIZATION 8 178 6.84e-07 1.341e-05
239 REGULATION OF UBIQUITIN PROTEIN LIGASE ACTIVITY 4 18 7.687e-07 1.497e-05
240 NEGATIVE REGULATION OF DEVELOPMENTAL PROCESS 15 801 7.831e-07 1.518e-05
241 RESPONSE TO KETONE 8 182 8.092e-07 1.562e-05
242 REPRODUCTION 19 1297 9.109e-07 1.751e-05
243 POSITIVE REGULATION OF DNA METABOLIC PROCESS 8 185 9.155e-07 1.753e-05
244 POSITIVE REGULATION OF TRANSPORT 16 936 1.064e-06 2.028e-05
245 ORGAN REGENERATION 6 83 1.158e-06 2.199e-05
246 REGULATION OF CELL MORPHOGENESIS INVOLVED IN DIFFERENTIATION 10 337 1.179e-06 2.231e-05
247 EPITHELIUM DEVELOPMENT 16 945 1.206e-06 2.271e-05
248 AGING 9 264 1.343e-06 2.519e-05
249 POSITIVE REGULATION OF PATHWAY RESTRICTED SMAD PROTEIN PHOSPHORYLATION 5 48 1.527e-06 2.853e-05
250 MEIOSIS I 6 88 1.635e-06 3.044e-05
251 REGULATION OF GROWTH 13 633 1.698e-06 3.147e-05
252 REGULATION OF CELL DIFFERENTIATION 20 1492 1.765e-06 3.259e-05
253 CELLULAR RESPONSE TO OXYGEN LEVELS 7 143 2.003e-06 3.684e-05
254 POSITIVE REGULATION OF MITOTIC NUCLEAR DIVISION 5 51 2.075e-06 3.8e-05
255 RESPONSE TO TRANSFORMING GROWTH FACTOR BETA 7 144 2.099e-06 3.83e-05
256 RESPONSE TO IONIZING RADIATION 7 145 2.198e-06 3.964e-05
257 POSITIVE REGULATION OF MULTICELLULAR ORGANISMAL METABOLIC PROCESS 4 23 2.19e-06 3.964e-05
258 POSITIVE REGULATION OF COLLAGEN METABOLIC PROCESS 4 23 2.19e-06 3.964e-05
259 TISSUE DEVELOPMENT 20 1518 2.303e-06 4.138e-05
260 PEPTIDYL SERINE MODIFICATION 7 148 2.52e-06 4.509e-05
261 CELLULAR RESPONSE TO LIPID 11 457 2.557e-06 4.553e-05
262 TRANSFORMING GROWTH FACTOR BETA RECEPTOR SIGNALING PATHWAY 6 95 2.563e-06 4.553e-05
263 REGULATION OF CYSTEINE TYPE ENDOPEPTIDASE ACTIVITY 8 213 2.631e-06 4.655e-05
264 INTERSPECIES INTERACTION BETWEEN ORGANISMS 13 662 2.78e-06 4.881e-05
265 SYMBIOSIS ENCOMPASSING MUTUALISM THROUGH PARASITISM 13 662 2.78e-06 4.881e-05
266 MEIOTIC CELL CYCLE PROCESS 7 152 3.009e-06 5.263e-05
267 NEGATIVE REGULATION OF DNA REPLICATION 5 55 3.033e-06 5.286e-05
268 POSITIVE REGULATION OF PROTEASOMAL PROTEIN CATABOLIC PROCESS 6 98 3.075e-06 5.338e-05
269 DNA DEPENDENT DNA REPLICATION 6 99 3.262e-06 5.643e-05
270 CELLULAR RESPONSE TO ORGANIC SUBSTANCE 22 1848 3.385e-06 5.834e-05
271 NEGATIVE REGULATION OF CELLULAR CATABOLIC PROCESS 7 156 3.574e-06 6.137e-05
272 REGULATION OF CELLULAR SENESCENCE 4 26 3.663e-06 6.266e-05
273 RESPONSE TO INORGANIC SUBSTANCE 11 479 4.012e-06 6.838e-05
274 CELLULAR RESPONSE TO REACTIVE OXYGEN SPECIES 6 104 4.346e-06 7.381e-05
275 REGENERATION 7 161 4.404e-06 7.452e-05
276 REGULATION OF CELLULAR RESPONSE TO GROWTH FACTOR STIMULUS 8 229 4.497e-06 7.582e-05
277 REGULATION OF PATHWAY RESTRICTED SMAD PROTEIN PHOSPHORYLATION 5 60 4.686e-06 7.872e-05
278 REGULATION OF DNA DAMAGE RESPONSE SIGNAL TRANSDUCTION BY P53 CLASS MEDIATOR 4 28 4.985e-06 8.344e-05
279 CELLULAR RESPONSE TO HYDROGEN PEROXIDE 5 61 5.088e-06 8.486e-05
280 PEPTIDYL LYSINE MODIFICATION 9 312 5.265e-06 8.738e-05
281 SENSORY ORGAN DEVELOPMENT 11 493 5.277e-06 8.738e-05
282 SOMITOGENESIS 5 62 5.517e-06 9.071e-05
283 POSITIVE REGULATION OF NUCLEAR DIVISION 5 62 5.517e-06 9.071e-05
284 NEGATIVE REGULATION OF GROWTH 8 236 5.612e-06 9.195e-05
285 NEGATIVE REGULATION OF PRODUCTION OF MOLECULAR MEDIATOR OF IMMUNE RESPONSE 4 29 5.765e-06 9.347e-05
286 REGULATION OF EXTRACELLULAR MATRIX ORGANIZATION 4 29 5.765e-06 9.347e-05
287 REGULATION OF HEART MORPHOGENESIS 4 29 5.765e-06 9.347e-05
288 NEGATIVE REGULATION OF DNA METABOLIC PROCESS 6 111 6.34e-06 0.0001024
289 REGULATION OF PROTEIN ACETYLATION 5 64 6.459e-06 0.0001036
290 POSITIVE REGULATION OF RESPONSE TO DNA DAMAGE STIMULUS 5 64 6.459e-06 0.0001036
291 GROWTH 10 410 6.748e-06 0.0001079
292 NOTCH SIGNALING PATHWAY 6 114 7.394e-06 0.0001178
293 NEGATIVE REGULATION OF RESPONSE TO STIMULUS 18 1360 7.754e-06 0.0001231
294 CELL AGING 5 67 8.103e-06 0.0001282
295 DEVELOPMENTAL GROWTH 9 333 8.895e-06 0.0001403
296 RESPONSE TO NITROGEN COMPOUND 14 859 9.48e-06 0.000149
297 PROTEIN COMPLEX SUBUNIT ORGANIZATION 19 1527 9.977e-06 0.0001563
298 REGULATION OF PROTEIN IMPORT 7 183 1.021e-05 0.0001594
299 NEGATIVE REGULATION OF CELLULAR SENESCENCE 3 11 1.07e-05 0.000166
300 ACTIVATION OF MAPKKK ACTIVITY 3 11 1.07e-05 0.000166
301 PROTEIN DESTABILIZATION 4 34 1.108e-05 0.0001713
302 MACROMOLECULAR COMPLEX ASSEMBLY 18 1398 1.131e-05 0.0001743
303 TRANSCRIPTION COUPLED NUCLEOTIDE EXCISION REPAIR 5 73 1.236e-05 0.0001898
304 RESPONSE TO MINERALOCORTICOID 4 35 1.247e-05 0.0001903
305 RESPONSE TO IRON ION 4 35 1.247e-05 0.0001903
306 CELLULAR RESPONSE TO EXTERNAL STIMULUS 8 264 1.271e-05 0.0001933
307 MESENCHYME DEVELOPMENT 7 190 1.303e-05 0.0001975
308 REGULATION OF MACROPHAGE CYTOKINE PRODUCTION 3 12 1.423e-05 0.0002143
309 POSITIVE REGULATION OF SMAD PROTEIN IMPORT INTO NUCLEUS 3 12 1.423e-05 0.0002143
310 TUBE DEVELOPMENT 11 552 1.525e-05 0.0002282
311 REGULATION OF CELL MORPHOGENESIS 11 552 1.525e-05 0.0002282
312 SOMITE DEVELOPMENT 5 78 1.71e-05 0.000255
313 REGULATION OF MULTICELLULAR ORGANISMAL METABOLIC PROCESS 4 38 1.742e-05 0.000259
314 POSITIVE REGULATION OF DNA DAMAGE RESPONSE SIGNAL TRANSDUCTION BY P53 CLASS MEDIATOR 3 13 1.844e-05 0.0002733
315 POSITIVE REGULATION OF CYTOPLASMIC TRANSPORT 8 282 2.044e-05 0.0003011
316 HEART DEVELOPMENT 10 466 2.045e-05 0.0003011
317 CELLULAR CATABOLIC PROCESS 17 1322 2.114e-05 0.0003103
318 NEGATIVE REGULATION OF CELL COMMUNICATION 16 1192 2.292e-05 0.0003353
319 POSITIVE REGULATION OF P38MAPK CASCADE 3 14 2.34e-05 0.0003414
320 IMMUNE SYSTEM DEVELOPMENT 11 582 2.485e-05 0.0003614
321 REGULATION OF INTRACELLULAR PROTEIN TRANSPORT 9 381 2.586e-05 0.0003749
322 POSITIVE REGULATION OF CHROMATIN MODIFICATION 5 85 2.598e-05 0.0003754
323 REGULATION OF CYTOPLASMIC TRANSPORT 10 481 2.68e-05 0.0003861
324 POSITIVE REGULATION OF DNA REPLICATION 5 86 2.749e-05 0.0003949
325 BETA CATENIN TCF COMPLEX ASSEMBLY 4 43 2.868e-05 0.0004106
326 RESPONSE TO ESTRADIOL 6 146 3.029e-05 0.0004323
327 REGULATION OF INTRACELLULAR SIGNAL TRANSDUCTION 19 1656 3.115e-05 0.0004433
328 CELLULAR RESPONSE TO STEROID HORMONE STIMULUS 7 218 3.157e-05 0.0004478
329 SEGMENTATION 5 89 3.246e-05 0.000459
330 PROTEIN LOCALIZATION TO CHROMOSOME 4 45 3.441e-05 0.0004827
331 REGULATION OF PROTEIN STABILITY 7 221 3.444e-05 0.0004827
332 MESONEPHROS DEVELOPMENT 5 90 3.426e-05 0.0004827
333 CHROMATIN REMODELING 6 150 3.526e-05 0.0004927
334 REGULATION OF SMAD PROTEIN IMPORT INTO NUCLEUS 3 16 3.579e-05 0.0004928
335 REGULATION OF EXIT FROM MITOSIS 3 16 3.579e-05 0.0004928
336 REGULATION OF MULTICELLULAR ORGANISMAL DEVELOPMENT 19 1672 3.557e-05 0.0004928
337 ORGAN MORPHOGENESIS 13 841 3.561e-05 0.0004928
338 CELLULAR RESPONSE TO ANTIBIOTIC 3 16 3.579e-05 0.0004928
339 REGULATION OF PROTEIN TARGETING 8 307 3.745e-05 0.0005141
340 NEGATIVE REGULATION OF CELL DIFFERENTIATION 11 609 3.76e-05 0.0005146
341 REGULATION OF CHROMATIN ORGANIZATION 6 152 3.798e-05 0.0005183
342 CELLULAR RESPONSE TO NITROGEN COMPOUND 10 505 4.047e-05 0.0005506
343 POSITIVE REGULATION OF MULTICELLULAR ORGANISMAL PROCESS 17 1395 4.189e-05 0.0005682
344 REGULATION OF DNA BIOSYNTHETIC PROCESS 5 94 4.224e-05 0.0005713
345 POSITIVE REGULATION OF CELLULAR COMPONENT BIOGENESIS 9 406 4.244e-05 0.0005724
346 POSITIVE REGULATION OF SIGNAL TRANSDUCTION BY P53 CLASS MEDIATOR 3 17 4.334e-05 0.0005794
347 POSITIVE REGULATION OF EXTRACELLULAR MATRIX ORGANIZATION 3 17 4.334e-05 0.0005794
348 REGULATION OF SISTER CHROMATID COHESION 3 17 4.334e-05 0.0005794
349 REGULATION OF LIPID KINASE ACTIVITY 4 48 4.452e-05 0.0005935
350 HEMATOPOIETIC PROGENITOR CELL DIFFERENTIATION 5 98 5.159e-05 0.000684
351 RESPONSE TO VITAMIN 5 98 5.159e-05 0.000684
352 POSITIVE REGULATION OF CELL CYCLE G2 M PHASE TRANSITION 3 18 5.185e-05 0.0006854
353 RESPONSE TO PROGESTERONE 4 50 5.236e-05 0.0006882
354 RESPONSE TO GAMMA RADIATION 4 50 5.236e-05 0.0006882
355 CELL DEVELOPMENT 17 1426 5.518e-05 0.0007232
356 RESPONSE TO AMMONIUM ION 4 51 5.664e-05 0.0007403
357 EYE DEVELOPMENT 8 326 5.719e-05 0.0007453
358 CELLULAR RESPONSE TO IONIZING RADIATION 4 52 6.117e-05 0.000795
359 NEGATIVE REGULATION OF TRANSMEMBRANE RECEPTOR PROTEIN SERINE THREONINE KINASE SIGNALING PATHWAY 5 102 6.248e-05 0.0008097
360 REGULATION OF CELLULAR COMPONENT BIOGENESIS 12 767 6.543e-05 0.0008457
361 INTRINSIC APOPTOTIC SIGNALING PATHWAY BY P53 CLASS MEDIATOR 4 53 6.596e-05 0.0008501
362 RESPONSE TO METAL ION 8 333 6.636e-05 0.0008529
363 EMBRYO DEVELOPMENT 13 894 6.659e-05 0.0008536
364 POSITIVE REGULATION OF PROTEIN IMPORT 5 104 6.854e-05 0.0008761
365 NEGATIVE REGULATION OF CELL CYCLE ARREST 3 20 7.201e-05 0.000918
366 CRANIAL SKELETAL SYSTEM DEVELOPMENT 4 55 7.635e-05 0.0009706
367 LYMPHOCYTE ACTIVATION 8 342 7.992e-05 0.001013
368 EPITHELIAL TO MESENCHYMAL TRANSITION 4 56 8.196e-05 0.001036
369 COVALENT CHROMATIN MODIFICATION 8 345 8.492e-05 0.001071
370 RESPONSE TO HYDROGEN PEROXIDE 5 109 8.569e-05 0.001078
371 MICROTUBULE CYTOSKELETON ORGANIZATION 8 348 9.018e-05 0.001131
372 POSITIVE REGULATION OF INTRACELLULAR PROTEIN TRANSPORT 7 258 9.142e-05 0.001143
373 NEGATIVE REGULATION OF CYTOKINE PRODUCTION INVOLVED IN IMMUNE RESPONSE 3 22 9.67e-05 0.001203
374 ENDOCARDIAL CUSHION MORPHOGENESIS 3 22 9.67e-05 0.001203
375 REGULATION OF CYTOKINE PRODUCTION 10 563 1e-04 0.001241
376 POSITIVE REGULATION OF DNA BIOSYNTHETIC PROCESS 4 59 0.0001006 0.001245
377 NUCLEOTIDE EXCISION REPAIR 5 113 0.0001016 0.001255
378 CELL ACTIVATION 10 568 0.0001076 0.001324
379 CELLULAR RESPONSE TO OXIDATIVE STRESS 6 184 0.0001096 0.001346
380 RESPONSE TO INCREASED OXYGEN LEVELS 3 23 0.0001109 0.001354
381 RESPONSE TO HYPEROXIA 3 23 0.0001109 0.001354
382 EMBRYONIC DIGIT MORPHOGENESIS 4 61 0.0001147 0.001397
383 POSITIVE REGULATION OF CELLULAR RESPONSE TO TRANSFORMING GROWTH FACTOR BETA STIMULUS 3 24 0.0001263 0.001531
384 POSITIVE REGULATION OF TRANSFORMING GROWTH FACTOR BETA RECEPTOR SIGNALING PATHWAY 3 24 0.0001263 0.001531
385 POSITIVE REGULATION OF CELL DIFFERENTIATION 12 823 0.0001275 0.001541
386 TRANSMEMBRANE RECEPTOR PROTEIN SERINE THREONINE KINASE SIGNALING PATHWAY 6 190 0.0001307 0.001575
387 CELLULAR MACROMOLECULE LOCALIZATION 15 1234 0.0001312 0.001578
388 POSITIVE REGULATION OF CELL DEVELOPMENT 9 472 0.0001341 0.001604
389 RESPONSE TO NUTRIENT 6 191 0.0001345 0.001604
390 RESPONSE TO REACTIVE OXYGEN SPECIES 6 191 0.0001345 0.001604
391 LENS FIBER CELL DIFFERENTIATION 3 25 0.0001431 0.001669
392 NEGATIVE REGULATION OF CELLULAR RESPONSE TO GROWTH FACTOR STIMULUS 5 121 0.0001403 0.001669
393 CELLULAR RESPONSE TO TOXIC SUBSTANCE 3 25 0.0001431 0.001669
394 REGULATION OF TRANSFORMING GROWTH FACTOR BETA PRODUCTION 3 25 0.0001431 0.001669
395 POSITIVE REGULATION OF PEPTIDYL THREONINE PHOSPHORYLATION 3 25 0.0001431 0.001669
396 EPITHELIAL CELL APOPTOTIC PROCESS 3 25 0.0001431 0.001669
397 NEGATIVE REGULATION OF IMMUNE SYSTEM PROCESS 8 372 0.0001428 0.001669
398 HISTONE PHOSPHORYLATION 3 25 0.0001431 0.001669
399 DEVELOPMENTAL MATURATION 6 193 0.0001423 0.001669
400 HEAD DEVELOPMENT 11 709 0.0001458 0.001696
401 ANTERIOR POSTERIOR PATTERN SPECIFICATION 6 194 0.0001464 0.001699
402 REGULATION OF CELL DEVELOPMENT 12 836 0.0001476 0.001708
403 NEGATIVE REGULATION OF CELLULAR RESPONSE TO TRANSFORMING GROWTH FACTOR BETA STIMULUS 4 66 0.0001559 0.001791
404 NEGATIVE REGULATION OF TRANSFORMING GROWTH FACTOR BETA RECEPTOR SIGNALING PATHWAY 4 66 0.0001559 0.001791
405 LENS DEVELOPMENT IN CAMERA TYPE EYE 4 66 0.0001559 0.001791
406 RESPONSE TO CORTICOSTERONE 3 26 0.0001613 0.001845
407 REGULATION OF P38MAPK CASCADE 3 26 0.0001613 0.001845
408 KIDNEY EPITHELIUM DEVELOPMENT 5 125 0.0001635 0.001864
409 POSITIVE REGULATION OF NEURON DEATH 4 67 0.0001653 0.001876
410 REGULATION OF DNA TEMPLATED TRANSCRIPTION IN RESPONSE TO STRESS 4 67 0.0001653 0.001876
411 TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 11 724 0.000175 0.001981
412 POSITIVE REGULATION OF BINDING 5 127 0.0001761 0.001988
413 MITOTIC SPINDLE ORGANIZATION 4 69 0.0001853 0.002087
414 PROTEIN COMPLEX BIOGENESIS 14 1132 0.0001896 0.002126
415 PROTEIN COMPLEX ASSEMBLY 14 1132 0.0001896 0.002126
416 EPITHELIAL CELL DIFFERENTIATION 9 495 0.0001914 0.002141
417 CELL MATURATION 5 131 0.0002035 0.00227
418 REGULATION OF PEPTIDASE ACTIVITY 8 392 0.0002041 0.002272
419 ENDODERM DEVELOPMENT 4 71 0.0002069 0.002298
420 LYMPHOCYTE DIFFERENTIATION 6 209 0.0002193 0.002429
421 NUCLEOTIDE EXCISION REPAIR PREINCISION COMPLEX ASSEMBLY 3 29 0.0002247 0.002484
422 POSITIVE REGULATION OF INTRACELLULAR SIGNAL TRANSDUCTION 12 876 0.0002274 0.002508
423 CATABOLIC PROCESS 18 1773 0.0002495 0.002744
424 CIRCADIAN RHYTHM 5 137 0.0002506 0.00275
425 PROTEIN TARGETING 8 406 0.0002587 0.002832
426 REGULATION OF PROTEIN COMPLEX DISASSEMBLY 6 217 0.0002684 0.002931
427 MULTICELLULAR ORGANISM REPRODUCTION 11 768 0.0002908 0.003168
428 LEUKOCYTE ACTIVATION 8 414 0.0002949 0.003206
429 SALIVARY GLAND DEVELOPMENT 3 32 0.0003024 0.003264
430 ENDOCARDIAL CUSHION DEVELOPMENT 3 32 0.0003024 0.003264
431 REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER IN RESPONSE TO HYPOXIA 3 32 0.0003024 0.003264
432 REGULATION OF TRANSPORT 18 1804 0.0003087 0.003325
433 REGULATION OF PROTEIN EXPORT FROM NUCLEUS 3 33 0.0003316 0.003564
434 RESPONSE TO ACID CHEMICAL 7 319 0.000336 0.003602
435 RESPONSE TO EXTERNAL STIMULUS 18 1821 0.0003461 0.003702
436 RESPONSE TO TRANSITION METAL NANOPARTICLE 5 148 0.0003579 0.003811
437 REGULATION OF GENE EXPRESSION EPIGENETIC 6 229 0.0003578 0.003811
438 HEART VALVE DEVELOPMENT 3 34 0.0003627 0.003853
439 RESPONSE TO MONOAMINE 3 35 0.0003955 0.004182
440 POSITIVE REGULATION OF OSSIFICATION 4 84 0.0003947 0.004182
441 CELLULAR RESPONSE TO OXYGEN CONTAINING COMPOUND 11 799 0.0004067 0.004291
442 TRANSCRIPTION INITIATION FROM RNA POLYMERASE II PROMOTER 5 153 0.0004169 0.004388
443 CELLULAR RESPONSE TO HORMONE STIMULUS 9 552 0.000426 0.004475
444 POSITIVE REGULATION OF PROTEIN ACETYLATION 3 36 0.0004302 0.004498
445 HEAD MORPHOGENESIS 3 36 0.0004302 0.004498
446 EMBRYO DEVELOPMENT ENDING IN BIRTH OR EGG HATCHING 9 554 0.0004373 0.004563
447 RESPONSE TO EXTRACELLULAR STIMULUS 8 441 0.0004492 0.004666
448 PROTEIN LOCALIZATION TO ORGANELLE 9 556 0.0004489 0.004666
449 TISSUE REMODELING 4 87 0.0004511 0.004675
450 REGULATION OF PEPTIDYL THREONINE PHOSPHORYLATION 3 37 0.0004668 0.004826
451 OVULATION CYCLE PROCESS 4 88 0.0004711 0.004839
452 NEGATIVE REGULATION OF CYSTEINE TYPE ENDOPEPTIDASE ACTIVITY 4 88 0.0004711 0.004839
453 RESPONSE TO TOXIC SUBSTANCE 6 241 0.0004692 0.004839
454 REGULATION OF ORGAN MORPHOGENESIS 6 242 0.0004795 0.004915
455 REGULATION OF DEPHOSPHORYLATION 5 158 0.0004829 0.004938
456 B CELL DIFFERENTIATION 4 89 0.0004918 0.005018
457 POSTTRANSCRIPTIONAL REGULATION OF GENE EXPRESSION 8 448 0.0004984 0.005075
458 POSITIVE REGULATION OF BIOMINERAL TISSUE DEVELOPMENT 3 38 0.0005053 0.005122
459 OOCYTE DIFFERENTIATION 3 38 0.0005053 0.005122
460 REGULATION OF CELL MATRIX ADHESION 4 90 0.0005131 0.00519
461 REGULATION OF IMMUNE SYSTEM PROCESS 15 1403 0.0005226 0.005275
462 CELLULAR RESPONSE TO NUTRIENT 3 39 0.0005458 0.005485
463 SPLEEN DEVELOPMENT 3 39 0.0005458 0.005485
464 REGULATION OF DNA BINDING 4 93 0.0005808 0.005825
465 POSITIVE REGULATION OF CELL MATRIX ADHESION 3 40 0.0005883 0.005886
466 REGULATION OF DNA DEPENDENT DNA REPLICATION 3 41 0.0006328 0.006279
467 NEGATIVE REGULATION OF FAT CELL DIFFERENTIATION 3 41 0.0006328 0.006279
468 LEUKOCYTE CELL CELL ADHESION 6 255 0.0006314 0.006279
469 ANDROGEN RECEPTOR SIGNALING PATHWAY 3 41 0.0006328 0.006279
470 RESPONSE TO CARBOHYDRATE 5 168 0.0006381 0.006317
471 NEGATIVE REGULATION OF PROTEIN COMPLEX DISASSEMBLY 5 170 0.0006732 0.006651
472 WOUND HEALING 8 470 0.0006823 0.006726
473 MITOCHONDRION ORGANIZATION 9 594 0.0007209 0.007092
474 EXTRINSIC APOPTOTIC SIGNALING PATHWAY 4 99 0.0007351 0.007216
475 MODIFICATION OF MORPHOLOGY OR PHYSIOLOGY OF OTHER ORGANISM 4 100 0.0007633 0.007446
476 REGULATION OF SMOOTH MUSCLE CELL PROLIFERATION 4 100 0.0007633 0.007446
477 PEPTIDYL TYROSINE DEPHOSPHORYLATION 4 100 0.0007633 0.007446
478 BODY MORPHOGENESIS 3 44 0.0007793 0.007586
479 RESPONSE TO CORTICOSTEROID 5 176 0.0007871 0.007646
480 DEVELOPMENTAL PROCESS INVOLVED IN REPRODUCTION 9 602 0.0007926 0.007667
481 REGULATION OF PRODUCTION OF MOLECULAR MEDIATOR OF IMMUNE RESPONSE 4 101 0.0007923 0.007667
482 POSITIVE REGULATION OF CYTOKINE PRODUCTION 7 370 0.0008105 0.007824
483 NEGATIVE REGULATION OF IMMUNE EFFECTOR PROCESS 4 102 0.0008221 0.00792
484 REGULATION OF OSSIFICATION 5 178 0.0008281 0.007961
485 EXOCRINE SYSTEM DEVELOPMENT 3 45 0.0008325 0.007987
486 RESPONSE TO COCAINE 3 46 0.000888 0.00845
487 REGULATION OF MITOTIC SPINDLE CHECKPOINT 2 11 0.0008917 0.00845
488 REGULATION OF EXTRACELLULAR MATRIX ASSEMBLY 2 11 0.0008917 0.00845
489 POSITIVE REGULATION OF RECEPTOR BIOSYNTHETIC PROCESS 2 11 0.0008917 0.00845
490 REGULATION OF MITOTIC CELL CYCLE SPINDLE ASSEMBLY CHECKPOINT 2 11 0.0008917 0.00845
491 EMBRYONIC CRANIAL SKELETON MORPHOGENESIS 3 46 0.000888 0.00845
492 REGULATION OF ANATOMICAL STRUCTURE MORPHOGENESIS 12 1021 0.0008949 0.008463
493 ODONTOGENESIS 4 105 0.0009163 0.008648
494 RESPONSE TO ANTIBIOTIC 3 47 0.0009457 0.00889
495 POSITIVE REGULATION OF NEURON APOPTOTIC PROCESS 3 47 0.0009457 0.00889
496 HOMOLOGOUS CHROMOSOME SEGREGATION 3 48 0.001006 0.009431
497 ACTIVATION OF PROTEIN KINASE ACTIVITY 6 279 0.001007 0.009431
498 CELLULAR RESPONSE TO EXTRACELLULAR STIMULUS 5 188 0.001058 0.009881
499 MITOTIC SISTER CHROMATID COHESION 2 12 0.001067 0.009951
NumGOOverlapSizeP ValueAdj. P Value
1 CYCLIN DEPENDENT PROTEIN SERINE THREONINE KINASE REGULATOR ACTIVITY 11 28 5.56e-20 5.165e-17
2 ENZYME BINDING 37 1737 2.243e-18 1.042e-15
3 KINASE BINDING 22 606 2.492e-15 7.716e-13
4 TRANSCRIPTION FACTOR BINDING 20 524 2.234e-14 5.189e-12
5 KINASE REGULATOR ACTIVITY 13 186 6.504e-13 1.209e-10
6 PROTEIN KINASE ACTIVITY 20 640 9.178e-13 1.421e-10
7 PROTEIN COMPLEX BINDING 23 935 1.86e-12 2.468e-10
8 CYCLIN DEPENDENT PROTEIN SERINE THREONINE KINASE INHIBITOR ACTIVITY 6 12 3.572e-12 4.148e-10
9 KINASE ACTIVITY 21 842 1.621e-11 1.673e-09
10 PROTEIN SERINE THREONINE KINASE INHIBITOR ACTIVITY 7 30 2.829e-11 2.324e-09
11 PROTEIN SERINE THREONINE KINASE ACTIVITY 16 445 3.002e-11 2.324e-09
12 MACROMOLECULAR COMPLEX BINDING 26 1399 2.671e-11 2.324e-09
13 TRANSFERASE ACTIVITY TRANSFERRING PHOSPHORUS CONTAINING GROUPS 21 992 3.344e-10 2.389e-08
14 RNA POLYMERASE II TRANSCRIPTION FACTOR BINDING 8 104 1.055e-08 7.002e-07
15 KINASE INHIBITOR ACTIVITY 7 89 7.886e-08 4.884e-06
16 ACTIVATING TRANSCRIPTION FACTOR BINDING 6 57 1.211e-07 7.034e-06
17 NF KAPPAB BINDING 5 30 1.346e-07 7.357e-06
18 CORE PROMOTER BINDING 8 152 2.049e-07 1.058e-05
19 CYCLIN DEPENDENT PROTEIN KINASE ACTIVITY 5 34 2.595e-07 1.269e-05
20 ENZYME REGULATOR ACTIVITY 17 959 2.774e-07 1.289e-05
21 UBIQUITIN LIKE PROTEIN LIGASE BINDING 9 264 1.343e-06 5.94e-05
22 TRANSFORMING GROWTH FACTOR BETA RECEPTOR BINDING 5 50 1.877e-06 7.927e-05
23 TRANSCRIPTION FACTOR ACTIVITY PROTEIN BINDING 12 588 4.731e-06 0.0001911
24 MOLECULAR FUNCTION REGULATOR 18 1353 7.222e-06 0.0002796
25 P53 BINDING 5 67 8.103e-06 0.0003011
26 SMAD BINDING 5 72 1.155e-05 0.0003975
27 CHROMATIN BINDING 10 435 1.13e-05 0.0003975
28 RNA POLYMERASE II ACTIVATING TRANSCRIPTION FACTOR BINDING 4 36 1.399e-05 0.0004642
29 ANDROGEN RECEPTOR BINDING 4 39 1.935e-05 0.0006199
30 STEROID HORMONE RECEPTOR BINDING 5 81 2.055e-05 0.0006365
31 LIGASE REGULATOR ACTIVITY 3 14 2.34e-05 0.0007014
32 NUCLEIC ACID BINDING TRANSCRIPTION FACTOR ACTIVITY 16 1199 2.462e-05 0.0007147
33 REGULATORY REGION NUCLEIC ACID BINDING 13 818 2.671e-05 0.0007519
34 PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR BINDING 3 15 2.917e-05 0.000797
35 CYCLIN BINDING 3 19 6.139e-05 0.001629
36 HISTONE DEACETYLASE BINDING 5 105 7.174e-05 0.001851
37 PROTEIN C TERMINUS BINDING 6 186 0.0001163 0.002771
38 R SMAD BINDING 3 23 0.0001109 0.002771
39 ADENYL NUCLEOTIDE BINDING 17 1514 0.0001155 0.002771
40 CORE PROMOTER PROXIMAL REGION DNA BINDING 8 371 0.0001402 0.003256
41 BHLH TRANSCRIPTION FACTOR BINDING 3 28 0.0002021 0.004579
42 RNA POLYMERASE II TRANSCRIPTION FACTOR ACTIVITY SEQUENCE SPECIFIC DNA BINDING 10 629 0.0002457 0.005436
43 DOUBLE STRANDED DNA BINDING 11 764 0.0002781 0.005983
44 RECEPTOR BINDING 16 1476 0.0002834 0.005983
45 CHROMATIN DNA BINDING 4 80 0.0003276 0.006763
46 BETA CATENIN BINDING 4 84 0.0003947 0.007971
NumGOOverlapSizeP ValueAdj. P Value
1 CHROMOSOME 28 880 4.783e-18 2.793e-15
2 TRANSCRIPTION FACTOR COMPLEX 18 298 1.945e-16 5.679e-14
3 TRANSFERASE COMPLEX 23 703 4.752e-15 6.937e-13
4 CYCLIN DEPENDENT PROTEIN KINASE HOLOENZYME COMPLEX 9 31 3.902e-15 6.937e-13
5 CHROMATIN 18 441 1.723e-13 2.013e-11
6 NUCLEAR CHROMOSOME 19 523 2.651e-13 2.58e-11
7 CHROMOSOMAL REGION 16 330 3.277e-13 2.734e-11
8 CATALYTIC COMPLEX 24 1038 2.041e-12 1.49e-10
9 PROTEIN KINASE COMPLEX 10 90 3.343e-12 2.169e-10
10 ANAPHASE PROMOTING COMPLEX 6 22 2.792e-10 1.63e-08
11 NUCLEAR UBIQUITIN LIGASE COMPLEX 7 42 3.603e-10 1.913e-08
12 CULLIN RING UBIQUITIN LIGASE COMPLEX 10 150 5.611e-10 2.731e-08
13 MICROTUBULE CYTOSKELETON 20 1068 7.834e-09 3.519e-07
14 SPINDLE 11 289 2.675e-08 1.116e-06
15 CHROMOSOME CENTROMERIC REGION 9 174 3.944e-08 1.536e-06
16 TRANSFERASE COMPLEX TRANSFERRING PHOSPHORUS CONTAINING GROUPS 10 237 4.58e-08 1.672e-06
17 UBIQUITIN LIGASE COMPLEX 10 262 1.171e-07 4.024e-06
18 CENTROSOME 12 487 6.704e-07 2.175e-05
19 CONDENSED NUCLEAR CHROMOSOME 6 85 1.333e-06 3.973e-05
20 CONDENSED CHROMOSOME 8 195 1.361e-06 3.973e-05
21 RNA POLYMERASE II TRANSCRIPTION FACTOR COMPLEX 6 101 3.666e-06 0.0001019
22 CONDENSED CHROMOSOME CENTROMERIC REGION 6 102 3.882e-06 0.0001031
23 CHROMOSOME TELOMERIC REGION 7 162 4.588e-06 0.0001165
24 NUCLEOLUS 14 848 8.192e-06 0.0001984
25 MICROTUBULE ORGANIZING CENTER 12 623 8.494e-06 0.0001984
26 CYTOSKELETON 22 1967 9.294e-06 0.0002088
27 KINETOCHORE 6 120 9.932e-06 0.0002148
28 SPINDLE POLE 6 126 1.313e-05 0.0002739
29 NUCLEAR TRANSCRIPTION FACTOR COMPLEX 6 127 1.374e-05 0.0002767
30 CONDENSED CHROMOSOME OUTER KINETOCHORE 3 12 1.423e-05 0.000277
31 NUCLEAR CHROMOSOME TELOMERIC REGION 6 132 1.712e-05 0.0003225
32 CONDENSED NUCLEAR CHROMOSOME CENTROMERIC REGION 3 18 5.185e-05 0.0009463
33 CYTOSKELETAL PART 17 1436 6.02e-05 0.001065
34 CARBOXY TERMINAL DOMAIN PROTEIN KINASE COMPLEX 3 22 9.67e-05 0.001661
35 NUCLEAR CHROMATIN 7 291 0.0001923 0.003209
36 TRANSCRIPTIONAL REPRESSOR COMPLEX 4 74 0.0002428 0.003939
37 SCF UBIQUITIN LIGASE COMPLEX 3 34 0.0003627 0.005724
38 NUCLEOPLASM PART 10 708 0.0006228 0.009572

Over-represented Pathway

NumPathwayPathviewOverlapSizeP ValueAdj. P Value
1 hsa04110_Cell_cycle 82 128 1.711e-195 3.08e-193
2 hsa04114_Oocyte_meiosis 20 114 1.058e-27 9.523e-26
3 hsa04115_p53_signaling_pathway 17 69 2.25e-26 1.35e-24
4 hsa04350_TGF.beta_signaling_pathway 16 85 8.506e-23 3.828e-21
5 hsa04390_Hippo_signaling_pathway 16 154 1.86e-18 6.697e-17
6 hsa04914_Progesterone.mediated_oocyte_maturation 13 87 2.746e-17 8.238e-16
7 hsa04151_PI3K_AKT_signaling_pathway 18 351 3.41e-15 8.768e-14
8 hsa04310_Wnt_signaling_pathway 12 151 1.16e-12 2.61e-11
9 hsa04120_Ubiquitin_mediated_proteolysis 10 139 2.65e-10 5.3e-09
10 hsa04722_Neurotrophin_signaling_pathway 7 127 9.027e-07 1.625e-05
11 hsa04520_Adherens_junction 5 73 1.236e-05 0.0002023
12 hsa04010_MAPK_signaling_pathway 8 268 1.417e-05 0.0002126
13 hsa04012_ErbB_signaling_pathway 5 87 2.908e-05 0.0004026
14 hsa03420_Nucleotide_excision_repair 4 45 3.441e-05 0.0004424
15 hsa04330_Notch_signaling_pathway 4 47 4.093e-05 0.0004767
16 hsa04630_Jak.STAT_signaling_pathway 6 155 4.238e-05 0.0004767
17 hsa04144_Endocytosis 6 203 0.0001873 0.001983
18 hsa03030_DNA_replication 3 36 0.0004302 0.004302
19 hsa04710_Circadian_rhythm_._mammal 2 23 0.003973 0.03764
20 hsa04916_Melanogenesis 3 101 0.008296 0.07467
21 hsa04510_Focal_adhesion 4 200 0.009253 0.07931
22 hsa04720_Long.term_potentiation 2 70 0.03351 0.2741
23 hsa04660_T_cell_receptor_signaling_pathway 2 108 0.07262 0.5447
24 hsa04380_Osteoclast_differentiation 2 128 0.09703 0.6639
25 hsa04360_Axon_guidance 2 130 0.09959 0.6639
26 hsa04141_Protein_processing_in_endoplasmic_reticulum 2 168 0.1512 0.9387

lncRNA-mediated sponge

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Num lncRNA miRNAs           miRNAs count     Gene Sponge regulatory network lncRNA log2FC lncRNA pvalue Gene log2FC Gene pvalue lncRNA-gene Pearson correlation
1 PCA3 hsa-let-7a-3p;hsa-let-7b-3p;hsa-miR-106b-5p;hsa-miR-130b-5p;hsa-miR-141-3p;hsa-miR-15b-5p;hsa-miR-16-2-3p;hsa-miR-16-5p;hsa-miR-181a-2-3p;hsa-miR-182-5p;hsa-miR-183-5p;hsa-miR-19b-3p;hsa-miR-224-3p;hsa-miR-301a-3p;hsa-miR-3065-3p;hsa-miR-424-5p;hsa-miR-590-3p;hsa-miR-590-5p;hsa-miR-93-5p;hsa-miR-96-5p 20 CCND2 Sponge network -2.778 8.0E-5 -0.496 0.3 0.318

Quest ID: 8a8ab153bba0d77a36faa39bb67e0b72