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This regulatory network was inferred from the input dataset. The miRNAs and mRNAs are presented as round and rectangle nodes respectively. The numerical value popped up upon mouse over the gene node is the log2 transformed fold-change of the gene expression between the two groups. All of the nodes are clickable, and the detailed information of the miRNAs/mRNAs and related cancer pathway will be displayed in another window. The edges between nodes are supported by both interactions (predicted or experimentally verified) and correlations learnt from cancer dataset. The numerical value popped up upon mouse over the edge is the correlation beat value (effect size) between the two nodes. The experimental evidences of the edges reported in previous cancer studies are highlighted by red/orange color. All of these information can be accessed by the "mouse-over" action. This network shows a full map of the miRNA-mRNA regulation of the input gene list(s), and the hub miRNAs (with the high network degree/betweenness centrality) would be the potential cancer drivers or tumor suppressors. The full result table can be accessed in the "Regulations" tab.

"miRNACancerMAP" is also a network visualization tool for users to draw their regulatory network by personal customization. Users can set the complexity of the network by limiting the number of nodes or edges. And the color of the nodes can be defined by different categories of the mRNAs and miRNAs, such as Gene-Ontology, pathway, and expression status. Users can also select to use network degree or network betweenness centrality to define the node size. And edges can be black or colored by the correlation. Purple edge means negative correlation (mostly found between miRNA and mRNA), and blue edge means positive correlation (found in PPI or miRNA-miRNA sponge effect). We can also add the protein-protein interactions (PPI) into the network. This result will show the cluster of genes regulated by some specific miRNAs. Additionally, miRNA-miRNA edges can be added by the "miRNA sponge" button, presenting some clusters of miRNAs that have the interactions via sponge effect.

miRNA-gene regulations

(Download full result)

Num microRNA           Gene miRNA log2FC miRNA pvalue Gene log2FC Gene pvalue Interaction Correlation beta Correlation P-value PMID Reported in cancer studies
1 hsa-miR-23a-3p APAF1 1.11 0 0.3 0.22769 miRNATAP -0.49 0 24992592; 24249161 Luciferase assay was performed to verify a putative target site of miR-23a in the 3'-UTR of apoptosis protease activating factor 1 APAF1 mRNA; The expression levels of miR-23a and APAF1 in CRC cell lines SW480 and SW620 and clinical samples were assessed using reverse transcription-quantitative real-time PCR RT-qPCR and Western blot; Moreover miR-23a up-regulation was coupled with APAF1 down-regulation in CRC tissue samples;We found that the expression of miR-23a was increased and the level of apoptosis-activating factor-1 APAF-1 was decreased in 5-FU-treated colon cancer cells compared to untreated cells; APAF-1 as a target gene of miR-23a was identified and miR-23a antisense-induced increase in the activation of caspase-9 was observed
2 hsa-miR-23b-3p APAF1 -0.29 0.18665 0.3 0.22769 miRNATAP -0.54 0 NA
3 hsa-miR-27a-3p APAF1 1.3 0 0.3 0.22769 miRNATAP -0.39 0 NA
4 hsa-miR-27b-3p APAF1 0.08 0.72527 0.3 0.22769 miRNATAP -0.48 0 NA
5 hsa-miR-708-3p APAF1 0.62 0.27536 0.3 0.22769 mirMAP -0.24 0 NA
6 hsa-miR-944 APAF1 3.33 0.01778 0.3 0.22769 miRNATAP -0.13 0 NA
7 hsa-miR-125a-3p ATM 1.2 0.00164 -0.39 0.08341 miRanda -0.13 0.00188 NA
8 hsa-miR-203a-3p ATM 1.45 0.03941 -0.39 0.08341 MirTarget -0.14 0 24145123; 27542403 miR 203 induces oxaliplatin resistance in colorectal cancer cells by negatively regulating ATM kinase; In silico analysis identified ataxia telangiectasia mutated ATM a primary mediator of the DNA damage response as a potential target of miR-203; Using TCGA database we identified a significant reverse correlation of miR-203 and ATM expression in CRC tissues; We validated ATM as a bona fide target of miR-203 in CRC cells; Mutation of the putative miR-203 binding site in the 3' untranslated region 3'UTR of the ATM mRNA abolished the inhibitory effect of miR-203 on ATM;MiR 203 inhibits tumor invasion and metastasis in gastric cancer by ATM; Our results showed that miR-203 was significantly downregulated in gastric cancer tissues and cells while ataxia telangiectasia mutated kinase ATM was upregulated in gastric cancer tissues and cells and was directly regulated by miR-203; ATM knockdown phenocopied the effect of miR-203 overexpression
9 hsa-miR-590-5p ATM 1.04 0.00027 -0.39 0.08341 mirMAP -0.17 0.00247 NA
10 hsa-miR-30b-5p ATR -0.43 0.05936 0.73 0.00017 mirMAP -0.19 0.00265 NA
11 hsa-miR-30a-5p BAX -1.72 0 1.23 0 miRNAWalker2 validate -0.15 0.00018 NA
12 hsa-miR-365a-3p BAX -0.89 0.00255 1.23 0 miRNAWalker2 validate -0.19 6.0E-5 24216611 MiR 365 induces gemcitabine resistance in pancreatic cancer cells by targeting the adaptor protein SHC1 and pro apoptotic regulator BAX
13 hsa-let-7a-2-3p BBC3 0.2 0.64356 1.16 0.00014 MirTarget -0.19 0.00032 NA
14 hsa-miR-149-5p BBC3 0.71 0.29685 1.16 0.00014 miRNATAP -0.13 7.0E-5 NA
15 hsa-miR-27b-3p BBC3 0.08 0.72527 1.16 0.00014 miRNATAP -0.25 0.00693 NA
16 hsa-miR-129-5p CASP8 -2.57 0 1.08 0 miRanda -0.14 0 NA
17 hsa-miR-143-3p CASP8 -0.66 0.04832 1.08 0 MirTarget -0.19 3.0E-5 NA
18 hsa-miR-193b-3p CASP9 0.28 0.45126 -0.31 0.11004 miRNAWalker2 validate -0.17 0 NA
19 hsa-miR-139-5p CCNB1 -1.83 0 2.86 0 miRanda -0.49 0 NA
20 hsa-miR-338-3p CCND1 -0.96 0.01915 0.62 0.1312 miRNAWalker2 validate; miRTarBase; miRanda -0.24 0.00086 NA
21 hsa-let-7a-3p CCND2 0.5 0.04111 -0.5 0.3 mirMAP -0.54 0.0001 20418948 MicroRNA let 7a inhibits proliferation of human prostate cancer cells in vitro and in vivo by targeting E2F2 and CCND2
22 hsa-let-7b-3p CCND2 0.22 0.29604 -0.5 0.3 mirMAP -0.46 0.00588 NA
23 hsa-miR-106b-5p CCND2 1.71 0 -0.5 0.3 miRNAWalker2 validate; miRTarBase; miRNATAP -0.42 9.0E-5 NA
24 hsa-miR-130b-5p CCND2 0.7 0.05101 -0.5 0.3 mirMAP -0.39 2.0E-5 NA
25 hsa-miR-141-3p CCND2 1.46 0.00116 -0.5 0.3 MirTarget; TargetScan -0.21 0.00436 NA
26 hsa-miR-15b-5p CCND2 1.62 0 -0.5 0.3 miRNATAP -0.44 0.00021 NA
27 hsa-miR-16-2-3p CCND2 1.8 0 -0.5 0.3 mirMAP -0.55 0 NA
28 hsa-miR-16-5p CCND2 1.01 1.0E-5 -0.5 0.3 miRNAWalker2 validate; miRNATAP -0.67 1.0E-5 NA
29 hsa-miR-181a-2-3p CCND2 0.9 0.00083 -0.5 0.3 mirMAP -0.38 0.00236 NA
30 hsa-miR-182-5p CCND2 0.89 0.03106 -0.5 0.3 miRNAWalker2 validate; miRTarBase; miRNATAP -0.32 9.0E-5 NA
31 hsa-miR-183-5p CCND2 1.66 0.00052 -0.5 0.3 miRNATAP -0.29 2.0E-5 NA
32 hsa-miR-19b-3p CCND2 0.76 0.00653 -0.5 0.3 miRNAWalker2 validate; MirTarget; miRNATAP -0.32 0.00853 NA
33 hsa-miR-21-3p CCND2 1.75 0 -0.5 0.3 mirMAP -0.33 0.0051 NA
34 hsa-miR-224-3p CCND2 1.52 0.0065 -0.5 0.3 mirMAP -0.27 4.0E-5 NA
35 hsa-miR-26b-5p CCND2 -0.3 0.16008 -0.5 0.3 mirMAP; miRNATAP -0.58 0.00034 NA
36 hsa-miR-301a-3p CCND2 1.45 1.0E-5 -0.5 0.3 miRNAWalker2 validate -0.38 0.0002 NA
37 hsa-miR-3065-3p CCND2 -1.04 0.02184 -0.5 0.3 MirTarget; miRNATAP -0.2 0.00685 NA
38 hsa-miR-3065-5p CCND2 -0.24 0.63312 -0.5 0.3 mirMAP -0.24 0.00057 NA
39 hsa-miR-424-5p CCND2 1.09 0.00042 -0.5 0.3 miRNATAP -0.39 0.0003 NA
40 hsa-miR-429 CCND2 1.4 0.009 -0.5 0.3 miRNATAP -0.19 0.002 NA
41 hsa-miR-450b-5p CCND2 0.46 0.13274 -0.5 0.3 MirTarget; PITA; miRNATAP -0.32 0.00413 NA
42 hsa-miR-590-3p CCND2 1.12 0.00016 -0.5 0.3 miRanda; mirMAP -0.33 0.00348 NA
43 hsa-miR-590-5p CCND2 1.04 0.00027 -0.5 0.3 mirMAP -0.41 0.00055 NA
44 hsa-miR-9-3p CCND2 0.33 0.54111 -0.5 0.3 MirTarget; mirMAP; miRNATAP -0.19 0.00361 NA
45 hsa-miR-93-5p CCND2 1.75 0 -0.5 0.3 miRNATAP -0.32 0.00244 NA
46 hsa-miR-96-5p CCND2 1.14 0.00943 -0.5 0.3 TargetScan; miRNATAP -0.33 3.0E-5 NA
47 hsa-miR-96-5p CCND3 1.14 0.00943 0.04 0.88352 TargetScan -0.12 0.00328 NA
48 hsa-miR-125b-5p CCNE1 -0.51 0.13327 2.19 0 miRNAWalker2 validate -0.26 0.00155 NA
49 hsa-miR-195-5p CCNE1 -0.91 0.00151 2.19 0 miRNAWalker2 validate; MirTarget; miRNATAP -0.43 1.0E-5 24402230 Furthermore through qPCR and western blot assays we showed that overexpression of miR-195-5p reduced CCNE1 mRNA and protein levels respectively
50 hsa-miR-497-5p CCNE1 -0.8 0.0036 2.19 0 MirTarget; miRNATAP -0.43 2.0E-5 24112607; 25909221; 24909281 Western blot assays confirmed that overexpression of miR-497 reduced cyclin E1 protein levels; Inhibited cellular growth suppressed cellular migration and invasion and G1 cell cycle arrest were observed upon overexpression of miR-497 in cells possibly by targeting cyclin E1;The effect of simultaneous overexpression of miR-497 and miR-34a on the inhibition of cell proliferation colony formation and tumor growth and the downregulation of cyclin E1 was stronger than the effect of each miRNA alone; The synergistic actions of miR-497 and miR-34a partly correlated with cyclin E1 levels; These results indicate cyclin E1 is downregulated by both miR-497 and miR-34a which synergistically retard the growth of human lung cancer cells;miR 497 suppresses proliferation of human cervical carcinoma HeLa cells by targeting cyclin E1; Furthermore the target effect of miR-497 on the CCNE1 was identified by dual-luciferase reporter assay system qRT-PCR and Western blotting; Over-expressed miR-497 in HeLa cells could suppress cell proliferation by targeting CCNE1
51 hsa-miR-26a-5p CCNE2 -0.38 0.04425 1.36 0 miRNAWalker2 validate; miRTarBase; miRNATAP -0.44 0.0001 24116110; 21901171 The loss of miR 26a mediated post transcriptional regulation of cyclin E2 in pancreatic cancer cell proliferation and decreased patient survival; The in vitro and in vivo assays showed that overexpression of miR-26a resulted in cell cycle arrest inhibited cell proliferation and decreased tumor growth which was associated with cyclin E2 downregulation;We also show that enforced expression of miR-26a in AML cells is able to inhibit cell cycle progression by downregulating cyclin E2 expression
52 hsa-miR-30a-5p CCNE2 -1.72 0 1.36 0 miRNATAP -0.22 0.00034 NA
53 hsa-let-7b-5p CCNG1 0.06 0.7814 -1.13 0 miRNAWalker2 validate -0.28 0.00054 NA
54 hsa-miR-1271-5p CCNG1 1.16 0.00208 -1.13 0 MirTarget -0.18 6.0E-5 26477861 MiR 1271 Inhibits Ovarian Cancer Growth by Targeting Cyclin G1; MiR-1271 exerted its role by targeting CCNG1
55 hsa-miR-21-5p CCNG1 1.75 0 -1.13 0 miRNAWalker2 validate -0.35 6.0E-5 NA
56 hsa-miR-23a-3p CCNG1 1.11 0 -1.13 0 MirTarget; miRNATAP -0.53 0 NA
57 hsa-miR-23b-3p CCNG1 -0.29 0.18665 -1.13 0 MirTarget; miRNATAP -0.23 0.00341 26872615 MiR 23b targets cyclin G1 and suppresses ovarian cancer tumorigenesis and progression; Dual-luciferase reporter assay and a xenograft mouse model were used to examine the expression of miR-23b and its target gene CCNG1; Dual-luciferase reporter assay showed that miR-23b bound with the 3' untranslated region of CCNG1; Furthermore miR-23b inhibited tumor growth and suppressed CCNG1 expression in vitro; Our findings show that miR-23b may inhibit ovarian cancer tumorigenesis and progression by downregulating CCNG1 and the expression of the relevant genes
58 hsa-miR-24-3p CCNG1 1.09 0 -1.13 0 miRNAWalker2 validate -0.46 0 NA
59 hsa-miR-27a-3p CCNG1 1.3 0 -1.13 0 MirTarget; miRNATAP -0.44 0 NA
60 hsa-miR-27b-3p CCNG1 0.08 0.72527 -1.13 0 MirTarget; miRNATAP -0.28 6.0E-5 26623719 Moreover miR-27b directly targets the 3' untranslated regions 3'-UTRs of CCNG1 a well-known negative regulator of P53 stability; Interestingly miR-27b up-regulation leads to increased miR-508-5p expression and this phenomenon is mediated by CCNG1 and P53
61 hsa-miR-299-5p CCNG1 -0.17 0.63894 -1.13 0 MirTarget -0.18 7.0E-5 NA
62 hsa-miR-409-3p CCNG1 0.65 0.05151 -1.13 0 MirTarget; PITA; miRNATAP -0.16 0.0017 NA
63 hsa-let-7f-1-3p CCNG2 1.29 0 -0.2 0.44774 MirTarget; mirMAP -0.28 6.0E-5 NA
64 hsa-miR-503-5p CCNG2 1.89 0 -0.2 0.44774 miRNAWalker2 validate -0.17 0.0003 NA
65 hsa-miR-145-5p CDK4 -1.75 2.0E-5 1.16 0 miRNAWalker2 validate; miRTarBase -0.13 0.00065 21092188 Furthermore we found that CDK4 was regulated by miR-145 in cell cycle control
66 hsa-miR-195-5p CDK4 -0.91 0.00151 1.16 0 miRNAWalker2 validate; miRTarBase -0.16 0.00344 NA
67 hsa-miR-101-3p CDK6 -0.45 0.02834 0.3 0.4008 mirMAP -0.39 0.00173 NA
68 hsa-miR-129-5p CDK6 -2.57 0 0.3 0.4008 miRNAWalker2 validate -0.13 0.00427 24055727 Interestingly we showed that cyclin dependent kinase 6 CDK6 a cell cycle-associated protein involved in G1-S transition was a target of miR-129
69 hsa-miR-30d-3p CDK6 -0.55 0.04337 0.3 0.4008 mirMAP -0.28 0.00298 NA
70 hsa-miR-30d-5p CDK6 -0.55 0.01401 0.3 0.4008 mirMAP -0.44 9.0E-5 NA
71 hsa-let-7d-5p CDKN1A 0.98 0 -0.53 0.09948 MirTarget -0.4 0.00048 NA
72 hsa-let-7g-5p CDKN1A 0.33 0.24114 -0.53 0.09948 MirTarget -0.31 0.00013 NA
73 hsa-let-7i-5p CDKN1A 0.8 3.0E-5 -0.53 0.09948 MirTarget -0.32 0.00701 NA
74 hsa-miR-101-3p CDKN1A -0.45 0.02834 -0.53 0.09948 MirTarget -0.45 6.0E-5 NA
75 hsa-miR-106b-5p CDKN1A 1.71 0 -0.53 0.09948 miRNAWalker2 validate; miRTarBase; MirTarget; miRNATAP -0.32 1.0E-5 NA
76 hsa-miR-146a-5p CDKN1A 1.82 2.0E-5 -0.53 0.09948 miRNAWalker2 validate -0.18 0.00045 NA
77 hsa-miR-17-5p CDKN1A 1.66 0 -0.53 0.09948 miRNAWalker2 validate; miRTarBase; MirTarget; TargetScan; miRNATAP -0.26 0.00022 26482648; 24989082 The low expressions of miR-17 and miR-92 families can maintain cisplatin resistance through the regulation of CDKN1A and RAD21;According to PicTar and Miranda algorithms which predicted CDKN1A p21 as a putative target of miR-17 a luciferase assay was performed and revealed that miR-17 directly targets the 3'-UTR of p21 mRNA
78 hsa-miR-20a-5p CDKN1A 1.45 0 -0.53 0.09948 miRNAWalker2 validate; miRTarBase; MirTarget; miRNATAP -0.31 4.0E-5 26012475 Using the poorly tumorigenic and TGF-β-sensitive FET cell line that expresses low miR-20a levels we first confirmed that miR-20a downmodulated CDKN1A expression both at mRNA and protein level through direct binding to its 3'-UTR; Moreover besides modulating CDKN1A miR-20a blocked TGF-β-induced transactivation of its promoter without affecting the post-receptor activation of Smad3/4 effectors directly; Finally miR-20a abrogated the TGF-β-mediated c-Myc repression a direct inhibitor of the CDKN1A promoter activation most likely by reducing the expression of specific MYC-regulating genes from the Smad/E2F-based core repressor complex
79 hsa-miR-30b-3p CDKN1A -0.27 0.40085 -0.53 0.09948 MirTarget -0.23 0.00125 NA
80 hsa-miR-335-5p CDKN1A 1.6 6.0E-5 -0.53 0.09948 miRNAWalker2 validate -0.32 0 NA
81 hsa-miR-345-5p CDKN1A 1.84 0 -0.53 0.09948 miRNAWalker2 validate; miRTarBase; MirTarget -0.24 0.00033 NA
82 hsa-miR-423-3p CDKN1A 0.82 0.00026 -0.53 0.09948 miRNAWalker2 validate; miRTarBase -0.32 0.00138 NA
83 hsa-miR-423-5p CDKN1A 0.83 0.00079 -0.53 0.09948 MirTarget -0.41 0 NA
84 hsa-miR-429 CDKN1A 1.4 0.009 -0.53 0.09948 miRNATAP -0.13 0.00128 NA
85 hsa-miR-93-5p CDKN1A 1.75 0 -0.53 0.09948 miRNAWalker2 validate; miRTarBase; MirTarget; miRNATAP -0.32 1.0E-5 25633810 MicroRNA 93 activates c Met/PI3K/Akt pathway activity in hepatocellular carcinoma by directly inhibiting PTEN and CDKN1A; We confirmed that miR-93 directly bound with the 3' untranslated regions of the tumor-suppressor genes PTEN and CDKN1A respectivelyand inhibited their expression; We concluded that miR-93 stimulated cell proliferation migration and invasion through the oncogenic c-Met/PI3K/Akt pathway and also inhibited apoptosis by directly inhibiting PTEN and CDKN1A expression in human HCC
86 hsa-miR-942-5p CDKN1A 1.91 0 -0.53 0.09948 miRNAWalker2 validate -0.18 0.00704 NA
87 hsa-miR-125b-5p CDKN2A -0.51 0.13327 1.06 0.26133 miRNAWalker2 validate -0.58 0.00347 23585871 In this study we further extend our studies by showing that miR-125b represses the protein product of the ink4a/ARF locus p14ARF in two prostate cancer cell lines LNCaP wild type-p53 and 22Rv1 both wild type and mutant p53 as well as in the PC-346C prostate cancer xenograft model that lentivirally overexpressed miR-125b; Conversely treatment of prostate cancer cells with an inhibitor of miR-125b anti-miR-125b resulted in increased expression of p14ARF decreased level of Mdm2 and induction of apoptosis; In addition overexpression of miR-125b in p53-deficient PC3 cells induced down-regulation of p14ARF which leads to increased cell proliferation through a p53-independent manner
88 hsa-miR-365a-3p CDKN2A -0.89 0.00255 1.06 0.26133 MirTarget -0.76 0.00074 NA
89 hsa-miR-129-5p CHEK1 -2.57 0 2.16 0 miRanda -0.14 0.00016 NA
90 hsa-miR-139-5p CHEK1 -1.83 0 2.16 0 miRanda -0.39 0 NA
91 hsa-miR-195-5p CHEK1 -0.91 0.00151 2.16 0 MirTarget; miRNATAP -0.34 0 25840419 MiR 195 suppresses non small cell lung cancer by targeting CHEK1; We discovered that CHEK1 was a direct target of miR-195 which decreased CHEK1 expression in lung cancer cells
92 hsa-miR-497-5p CHEK1 -0.8 0.0036 2.16 0 MirTarget; miRNATAP -0.35 0 24464213 Checkpoint kinase 1 is negatively regulated by miR 497 in hepatocellular carcinoma; In silico analysis showed that CHEK1 was a candidate target of miR-497 which was previously found to be downregulated in HCC by us; To test whether miR-497 could bind to 3'untranslated region 3'UTR of CHEK1 luciferase reporter assay was conducted; The result revealed that miR-497 could bind to the 3'untranslated region 3'UTR of CHEK1 mRNA; Western blot showed that ectopic expression of miR-497 suppressed the CHEK1 expression and inhibition of miR-497 led to significant upregulation of CHEK1; Finally miR-497 expression was measured in the same 30 HCC samples and the correlation between miR-497 and CHEK1 was analyzed; The results indicated that miR-497 was downregulated in HCC and had a significant negative correlation with CHEK1; Taken together these results demonstrated that CHEK1 was negatively regulated by miR-497 and the overexpressed CHEK1 was resulted from the downregulated miR-497 in HCC which provided a potential molecular target for HCC therapy
93 hsa-miR-342-3p CYCS 0.32 0.26915 0.2 0.35913 mirMAP -0.21 8.0E-5 NA
94 hsa-miR-326 DDB2 -0.43 0.26299 0.67 0.00378 miRanda -0.18 4.0E-5 NA
95 hsa-miR-106a-5p FAS -0.17 0.64287 0.66 0.0207 miRNAWalker2 validate; miRTarBase -0.16 0.00429 22431000; 27142596 miR 106a is frequently upregulated in gastric cancer and inhibits the extrinsic apoptotic pathway by targeting FAS; Bioinformatic analysis combining with validation experiments identified FAS as a direct target of miR-106a; Moreover a significant inverse correlation was found between miR-106a and FAS expression not only in gastric cancer cell lines but also in gastric cancer specimens; Taken together these findings suggest that ectopicly overexpressed miR-106a may play an oncogenic role in gastric carcinogenesis and impair extrinsic apoptotic pathway through targeting FAS;Functional experiment ascertained that miR-106a interacted with FAS and mediated caspase3 pathway
96 hsa-miR-129-5p FAS -2.57 0 0.66 0.0207 miRanda -0.12 0.0007 NA
97 hsa-miR-148b-3p GADD45A 0.3 0.17466 -0.74 0.00247 MirTarget -0.21 0.00928 NA
98 hsa-miR-454-3p GADD45A 0.63 0.01349 -0.74 0.00247 MirTarget; miRNATAP -0.22 0.00181 NA
99 hsa-miR-1976 GADD45B 0.92 0.00012 -1.92 0 miRNATAP -0.59 0 NA
100 hsa-miR-324-3p GADD45B 1.05 0.00039 -1.92 0 MirTarget; miRNATAP -0.37 2.0E-5 NA
101 hsa-miR-590-3p GADD45B 1.12 0.00016 -1.92 0 miRanda -0.37 2.0E-5 NA
102 hsa-miR-296-5p GADD45G 0.93 0.06024 -1.31 0.00093 miRNATAP -0.17 0.00457 NA
103 hsa-miR-139-5p GTSE1 -1.83 0 3.35 0 miRanda -0.46 0 NA
104 hsa-let-7a-3p IGF1 0.5 0.04111 -2.08 0.00135 mirMAP -0.55 0.00422 NA
105 hsa-let-7b-3p IGF1 0.22 0.29604 -2.08 0.00135 mirMAP -0.64 0.00549 NA
106 hsa-let-7f-1-3p IGF1 1.29 0 -2.08 0.00135 mirMAP -0.85 0 NA
107 hsa-miR-103a-2-5p IGF1 0.81 0.01999 -2.08 0.00135 mirMAP -0.55 3.0E-5 NA
108 hsa-miR-130b-3p IGF1 1.33 5.0E-5 -2.08 0.00135 MirTarget -0.9 0 NA
109 hsa-miR-15b-3p IGF1 1.76 0 -2.08 0.00135 mirMAP -0.97 0 NA
110 hsa-miR-16-1-3p IGF1 1.43 0 -2.08 0.00135 mirMAP -0.89 0 NA
111 hsa-miR-181b-5p IGF1 1.64 0 -2.08 0.00135 mirMAP -0.48 0.00175 NA
112 hsa-miR-186-5p IGF1 0.15 0.43471 -2.08 0.00135 mirMAP -0.85 0.00061 NA
113 hsa-miR-19a-3p IGF1 1.27 0.00011 -2.08 0.00135 MirTarget -0.77 0 NA
114 hsa-miR-19b-1-5p IGF1 1.39 0 -2.08 0.00135 mirMAP -0.93 0 NA
115 hsa-miR-19b-3p IGF1 0.76 0.00653 -2.08 0.00135 MirTarget -0.82 0 NA
116 hsa-miR-20a-3p IGF1 1.14 0.00045 -2.08 0.00135 mirMAP -0.99 0 NA
117 hsa-miR-27a-3p IGF1 1.3 0 -2.08 0.00135 miRNAWalker2 validate; miRTarBase -0.62 0.00158 NA
118 hsa-miR-301a-3p IGF1 1.45 1.0E-5 -2.08 0.00135 MirTarget -0.44 0.00199 NA
119 hsa-miR-301b-3p IGF1 1.1 0.07156 -2.08 0.00135 MirTarget -0.49 0 NA
120 hsa-miR-3065-5p IGF1 -0.24 0.63312 -2.08 0.00135 mirMAP -0.28 0.00304 NA
121 hsa-miR-32-3p IGF1 0.58 0.11837 -2.08 0.00135 mirMAP -0.53 0.00017 NA
122 hsa-miR-320a IGF1 0.59 0.0119 -2.08 0.00135 miRNATAP -0.57 0.00471 NA
123 hsa-miR-320b IGF1 1.11 0.0005 -2.08 0.00135 miRNATAP -0.64 1.0E-5 NA
124 hsa-miR-320c IGF1 0.46 0.24061 -2.08 0.00135 miRNATAP -0.42 0.00294 NA
125 hsa-miR-33a-3p IGF1 0.35 0.32171 -2.08 0.00135 MirTarget -0.68 0 NA
126 hsa-miR-3662 IGF1 1.83 0.0054 -2.08 0.00135 MirTarget -0.45 0 NA
127 hsa-miR-421 IGF1 1.81 0 -2.08 0.00135 PITA -0.45 0.00067 NA
128 hsa-miR-454-3p IGF1 0.63 0.01349 -2.08 0.00135 MirTarget -0.55 0.00337 NA
129 hsa-miR-486-5p IGF1 -0.63 0.15527 -2.08 0.00135 PITA; miRNATAP -0.38 0.00034 NA
130 hsa-miR-576-5p IGF1 0.63 0.04171 -2.08 0.00135 PITA; mirMAP; miRNATAP -0.76 0 NA
131 hsa-miR-577 IGF1 0.91 0.22561 -2.08 0.00135 PITA -0.36 0 NA
132 hsa-miR-590-3p IGF1 1.12 0.00016 -2.08 0.00135 MirTarget; miRanda; mirMAP; miRNATAP -0.61 8.0E-5 NA
133 hsa-miR-592 IGF1 0.78 0.2045 -2.08 0.00135 mirMAP -0.41 0 NA
134 hsa-miR-629-5p IGF1 1.06 0.00054 -2.08 0.00135 mirMAP -0.88 0 NA
135 hsa-miR-940 IGF1 1.64 0.00069 -2.08 0.00135 MirTarget; PITA; miRNATAP -0.45 5.0E-5 NA
136 hsa-miR-143-3p MDM2 -0.66 0.04832 0.1 0.72515 miRNAWalker2 validate -0.19 0.00073 NA
137 hsa-let-7b-5p MDM4 0.06 0.7814 -0.43 0.0212 miRNAWalker2 validate; MirTarget -0.16 0.00995 NA
138 hsa-miR-127-5p MDM4 0.68 0.02163 -0.43 0.0212 mirMAP -0.13 0.0034 NA
139 hsa-miR-152-3p MDM4 0.44 0.1617 -0.43 0.0212 MirTarget -0.2 0 NA
140 hsa-miR-22-5p MDM4 0.8 0.0008 -0.43 0.0212 MirTarget -0.17 0.00197 NA
141 hsa-miR-27a-3p MDM4 1.3 0 -0.43 0.0212 miRNATAP -0.32 0 NA
142 hsa-miR-27b-3p MDM4 0.08 0.72527 -0.43 0.0212 miRNATAP -0.22 5.0E-5 NA
143 hsa-miR-126-5p PERP 0.42 0.07532 1.62 0.00158 mirMAP -0.42 0.00796 NA
144 hsa-miR-150-5p PERP 0.15 0.75372 1.62 0.00158 MirTarget -0.22 0.00462 NA
145 hsa-miR-192-5p PERP 0.08 0.94106 1.62 0.00158 miRNAWalker2 validate -0.28 0 NA
146 hsa-miR-215-5p PERP 0.72 0.57378 1.62 0.00158 miRNAWalker2 validate -0.22 0 NA
147 hsa-miR-29b-1-5p PERP 0.61 0.11636 1.62 0.00158 MirTarget -0.25 0.00925 NA
148 hsa-miR-362-3p PERP -0.03 0.91378 1.62 0.00158 miRanda -0.46 6.0E-5 NA
149 hsa-miR-577 PERP 0.91 0.22561 1.62 0.00158 PITA -0.22 1.0E-5 NA
150 hsa-miR-660-5p PERP -0.02 0.93887 1.62 0.00158 MirTarget -0.92 0 NA

Over-represented Gene Ontology Biological Process

NumGOOverlapSizeP ValueAdj. P Value
1 REGULATION OF CELL CYCLE 27 949 1.089e-23 5.069e-20
2 CELL CYCLE 29 1316 1.362e-22 3.168e-19
3 CELL CYCLE PROCESS 25 1081 1.496e-19 2.32e-16
4 REGULATION OF CELL DEATH 27 1472 9.966e-19 1.159e-15
5 POSITIVE REGULATION OF CELL DEATH 20 605 2.294e-18 2.135e-15
6 NEGATIVE REGULATION OF CELL CYCLE 18 433 3.098e-18 2.402e-15
7 MITOTIC CELL CYCLE 21 766 1.136e-17 7.551e-15
8 RESPONSE TO ABIOTIC STIMULUS 23 1024 1.47e-17 7.601e-15
9 CELL CYCLE CHECKPOINT 14 194 1.468e-17 7.601e-15
10 REGULATION OF CELL CYCLE ARREST 12 108 1.942e-17 9.038e-15
11 POSITIVE REGULATION OF PROTEIN METABOLIC PROCESS 26 1492 2.192e-17 9.271e-15
12 POSITIVE REGULATION OF CELL CYCLE 16 332 3.233e-17 1.254e-14
13 CELLULAR RESPONSE TO STRESS 26 1565 7.054e-17 2.344e-14
14 CELLULAR RESPONSE TO DNA DAMAGE STIMULUS 20 720 6.694e-17 2.344e-14
15 CELL DEATH 22 1001 1.537e-16 4.47e-14
16 SIGNAL TRANSDUCTION BY P53 CLASS MEDIATOR 12 127 1.451e-16 4.47e-14
17 POSITIVE REGULATION OF CELL CYCLE PROCESS 14 247 4.407e-16 1.139e-13
18 NEGATIVE REGULATION OF CELL CYCLE G1 S PHASE TRANSITION 11 98 4.267e-16 1.139e-13
19 DNA INTEGRITY CHECKPOINT 12 146 8.046e-16 1.97e-13
20 G1 DNA DAMAGE CHECKPOINT 10 73 1.294e-15 3.011e-13
21 NEGATIVE REGULATION OF CELL CYCLE PROCESS 13 214 2.317e-15 5.135e-13
22 POSITIVE REGULATION OF CELL CYCLE ARREST 10 85 6.384e-15 1.35e-12
23 REGULATION OF MITOTIC CELL CYCLE 16 468 7.107e-15 1.438e-12
24 REGULATION OF PROTEOLYSIS 18 711 1.791e-14 3.473e-12
25 ACTIVATION OF CYSTEINE TYPE ENDOPEPTIDASE ACTIVITY 10 95 2.026e-14 3.771e-12
26 SIGNAL TRANSDUCTION IN RESPONSE TO DNA DAMAGE 10 96 2.258e-14 4.041e-12
27 AGING 13 264 3.515e-14 5.452e-12
28 NEGATIVE REGULATION OF MITOTIC CELL CYCLE 12 199 3.434e-14 5.452e-12
29 MITOTIC DNA INTEGRITY CHECKPOINT 10 100 3.441e-14 5.452e-12
30 CELLULAR RESPONSE TO ABIOTIC STIMULUS 13 263 3.347e-14 5.452e-12
31 NEGATIVE REGULATION OF CELL CYCLE PHASE TRANSITION 11 146 3.84e-14 5.763e-12
32 REGULATION OF CELL CYCLE G1 S PHASE TRANSITION 11 147 4.143e-14 6.024e-12
33 INTRINSIC APOPTOTIC SIGNALING PATHWAY 11 152 6.012e-14 8.477e-12
34 REGULATION OF CYSTEINE TYPE ENDOPEPTIDASE ACTIVITY 12 213 7.759e-14 1.062e-11
35 POSITIVE REGULATION OF PROTEOLYSIS 14 363 9.053e-14 1.204e-11
36 APOPTOTIC SIGNALING PATHWAY 13 289 1.123e-13 1.412e-11
37 ZYMOGEN ACTIVATION 10 112 1.102e-13 1.412e-11
38 REGULATION OF TRANSFERASE ACTIVITY 19 946 1.747e-13 2.139e-11
39 REGULATION OF PEPTIDASE ACTIVITY 14 392 2.583e-13 3.081e-11
40 RESPONSE TO OXYGEN LEVELS 13 311 2.867e-13 3.334e-11
41 RESPONSE TO UV 10 126 3.661e-13 4.154e-11
42 REGULATION OF CELL CYCLE PHASE TRANSITION 13 321 4.289e-13 4.752e-11
43 CELL CYCLE PHASE TRANSITION 12 255 6.608e-13 7.151e-11
44 CELLULAR RESPONSE TO RADIATION 10 137 8.548e-13 9.039e-11
45 REGULATION OF PROTEIN MODIFICATION PROCESS 23 1710 8.953e-13 9.258e-11
46 MITOTIC CELL CYCLE CHECKPOINT 10 139 9.896e-13 1.001e-10
47 REGULATION OF KINASE ACTIVITY 17 776 1.183e-12 1.171e-10
48 REGULATION OF CYCLIN DEPENDENT PROTEIN KINASE ACTIVITY 9 97 1.458e-12 1.413e-10
49 REGULATION OF CELL CYCLE PROCESS 15 558 1.876e-12 1.781e-10
50 REGULATION OF APOPTOTIC SIGNALING PATHWAY 13 363 2.037e-12 1.896e-10
51 POSITIVE REGULATION OF PEPTIDASE ACTIVITY 10 154 2.777e-12 2.533e-10
52 REGULATION OF PROTEIN SERINE THREONINE KINASE ACTIVITY 14 470 3.005e-12 2.689e-10
53 CELLULAR RESPONSE TO UV 8 66 3.083e-12 2.706e-10
54 REGULATION OF RESPONSE TO STRESS 21 1468 4.281e-12 3.689e-10
55 POSITIVE REGULATION OF APOPTOTIC SIGNALING PATHWAY 10 171 7.917e-12 6.698e-10
56 POSITIVE REGULATION OF CATALYTIC ACTIVITY 21 1518 8.112e-12 6.74e-10
57 RESPONSE TO RADIATION 13 413 1.031e-11 8.417e-10
58 INTRACELLULAR SIGNAL TRANSDUCTION 21 1572 1.576e-11 1.264e-09
59 POSITIVE REGULATION OF MOLECULAR FUNCTION 22 1791 2.159e-11 1.703e-09
60 REGULATION OF PHOSPHORUS METABOLIC PROCESS 21 1618 2.719e-11 2.109e-09
61 REGULATION OF CELLULAR RESPONSE TO STRESS 15 691 3.891e-11 2.968e-09
62 CELLULAR RESPONSE TO LIGHT STIMULUS 8 91 4.363e-11 3.274e-09
63 REPLICATIVE SENESCENCE 5 12 5.025e-11 3.711e-09
64 REGULATION OF CELL PROLIFERATION 20 1496 5.82e-11 4.232e-09
65 CELL CYCLE ARREST 9 154 9.76e-11 6.881e-09
66 POSITIVE REGULATION OF INTRACELLULAR SIGNAL TRANSDUCTION 16 876 9.679e-11 6.881e-09
67 REGULATION OF SIGNAL TRANSDUCTION BY P53 CLASS MEDIATOR 9 162 1.536e-10 1.067e-08
68 CELL CYCLE G1 S PHASE TRANSITION 8 111 2.187e-10 1.475e-08
69 G1 S TRANSITION OF MITOTIC CELL CYCLE 8 111 2.187e-10 1.475e-08
70 RESPONSE TO DRUG 12 431 2.976e-10 1.978e-08
71 REGULATION OF INTRACELLULAR SIGNAL TRANSDUCTION 20 1656 3.575e-10 2.343e-08
72 POSITIVE REGULATION OF PROTEIN MODIFICATION PROCESS 17 1135 4.64e-10 2.999e-08
73 PROTEIN MATURATION 10 265 5.913e-10 3.769e-08
74 REGULATION OF FIBROBLAST PROLIFERATION 7 81 8.835e-10 5.555e-08
75 RESPONSE TO LIGHT STIMULUS 10 280 1.008e-09 6.256e-08
76 RESPONSE TO STEROID HORMONE 12 497 1.502e-09 9.196e-08
77 RESPONSE TO IONIZING RADIATION 8 145 1.856e-09 1.122e-07
78 REGULATION OF EXTRINSIC APOPTOTIC SIGNALING PATHWAY 8 153 2.842e-09 1.695e-07
79 INTRINSIC APOPTOTIC SIGNALING PATHWAY BY P53 CLASS MEDIATOR 6 53 2.914e-09 1.716e-07
80 REGULATION OF EXTRINSIC APOPTOTIC SIGNALING PATHWAY VIA DEATH DOMAIN RECEPTORS 6 55 3.667e-09 2.133e-07
81 RESPONSE TO METAL ION 10 333 5.341e-09 3.068e-07
82 REGULATION OF DNA DAMAGE RESPONSE SIGNAL TRANSDUCTION BY P53 CLASS MEDIATOR 5 28 6.059e-09 3.438e-07
83 CELL DIVISION 11 460 8.876e-09 4.976e-07
84 POSITIVE REGULATION OF PHOSPHATE METABOLIC PROCESS 15 1036 1.024e-08 5.604e-07
85 POSITIVE REGULATION OF PHOSPHORUS METABOLIC PROCESS 15 1036 1.024e-08 5.604e-07
86 RESPONSE TO KETONE 8 182 1.115e-08 6.031e-07
87 CELLULAR RESPONSE TO EXTERNAL STIMULUS 9 264 1.136e-08 6.075e-07
88 RESPONSE TO ALCOHOL 10 362 1.183e-08 6.256e-07
89 RESPONSE TO LIPID 14 888 1.231e-08 6.386e-07
90 CELL AGING 6 67 1.235e-08 6.386e-07
91 POSITIVE REGULATION OF TRANSFERASE ACTIVITY 12 616 1.656e-08 8.466e-07
92 DNA METABOLIC PROCESS 13 758 1.7e-08 8.597e-07
93 INTRINSIC APOPTOTIC SIGNALING PATHWAY IN RESPONSE TO DNA DAMAGE 6 71 1.76e-08 8.805e-07
94 RESPONSE TO ORGANIC CYCLIC COMPOUND 14 917 1.846e-08 9.139e-07
95 NEGATIVE REGULATION OF PROTEIN METABOLIC PROCESS 15 1087 1.948e-08 9.539e-07
96 NEURON APOPTOTIC PROCESS 5 35 1.976e-08 9.579e-07
97 POSITIVE REGULATION OF DNA DAMAGE RESPONSE SIGNAL TRANSDUCTION BY P53 CLASS MEDIATOR 4 13 2.055e-08 9.856e-07
98 POSITIVE REGULATION OF MITOCHONDRIAL OUTER MEMBRANE PERMEABILIZATION INVOLVED IN APOPTOTIC SIGNALING PATHWAY 5 36 2.291e-08 1.088e-06
99 NEGATIVE REGULATION OF CELL PROLIFERATION 12 643 2.658e-08 1.249e-06
100 DNA REPLICATION 8 208 3.159e-08 1.47e-06
101 POSITIVE REGULATION OF CELL COMMUNICATION 17 1532 4.236e-08 1.952e-06
102 RESPONSE TO ESTROGEN 8 218 4.546e-08 2.074e-06
103 CELLULAR RESPONSE TO OXYGEN LEVELS 7 143 4.75e-08 2.146e-06
104 REGULATION OF PROTEIN STABILITY 8 221 5.053e-08 2.261e-06
105 REGULATION OF RESPONSE TO DNA DAMAGE STIMULUS 7 145 5.227e-08 2.316e-06
106 REGULATION OF MITOCHONDRIAL OUTER MEMBRANE PERMEABILIZATION INVOLVED IN APOPTOTIC SIGNALING PATHWAY 5 43 5.777e-08 2.536e-06
107 RESPONSE TO OXYGEN CONTAINING COMPOUND 16 1381 6.67e-08 2.901e-06
108 POSITIVE REGULATION OF SIGNAL TRANSDUCTION BY P53 CLASS MEDIATOR 4 17 6.791e-08 2.926e-06
109 PROTEOLYSIS 15 1208 7.871e-08 3.36e-06
110 RESPONSE TO EXTERNAL STIMULUS 18 1821 8.661e-08 3.664e-06
111 NEURON DEATH 5 47 9.14e-08 3.797e-06
112 POSITIVE REGULATION OF NEURON APOPTOTIC PROCESS 5 47 9.14e-08 3.797e-06
113 RESPONSE TO TOXIC SUBSTANCE 8 241 9.855e-08 4.058e-06
114 REGENERATION 7 161 1.072e-07 4.377e-06
115 RESPONSE TO HORMONE 13 893 1.159e-07 4.691e-06
116 RESPONSE TO ENDOGENOUS STIMULUS 16 1450 1.309e-07 5.249e-06
117 NEGATIVE REGULATION OF CELL CYCLE ARREST 4 20 1.375e-07 5.469e-06
118 NEGATIVE REGULATION OF MOLECULAR FUNCTION 14 1079 1.399e-07 5.515e-06
119 POSITIVE REGULATION OF CELLULAR PROTEIN LOCALIZATION 9 360 1.621e-07 6.339e-06
120 RESPONSE TO INORGANIC SUBSTANCE 10 479 1.636e-07 6.343e-06
121 POSITIVE REGULATION OF FIBROBLAST PROLIFERATION 5 53 1.692e-07 6.451e-06
122 POSITIVE REGULATION OF EXTRINSIC APOPTOTIC SIGNALING PATHWAY 5 53 1.692e-07 6.451e-06
123 POSITIVE REGULATION OF KINASE ACTIVITY 10 482 1.733e-07 6.556e-06
124 RESPONSE TO CORTICOSTEROID 7 176 1.97e-07 7.392e-06
125 POSITIVE REGULATION OF RESPONSE TO STIMULUS 18 1929 2.077e-07 7.672e-06
126 POSITIVE REGULATION OF PROTEIN OLIGOMERIZATION 4 22 2.069e-07 7.672e-06
127 REGULATION OF CELL CYCLE G2 M PHASE TRANSITION 5 59 2.919e-07 1.07e-05
128 POSITIVE REGULATION OF PROTEIN SERINE THREONINE KINASE ACTIVITY 8 289 3.944e-07 1.434e-05
129 NEGATIVE REGULATION OF CATALYTIC ACTIVITY 12 829 4.177e-07 1.503e-05
130 RESPONSE TO CORTICOSTERONE 4 26 4.199e-07 1.503e-05
131 NEGATIVE REGULATION OF APOPTOTIC SIGNALING PATHWAY 7 200 4.684e-07 1.664e-05
132 POSITIVE REGULATION OF MITOTIC CELL CYCLE 6 123 4.754e-07 1.676e-05
133 POSITIVE REGULATION OF NEURON DEATH 5 67 5.552e-07 1.942e-05
134 POSITIVE REGULATION OF LEUKOCYTE APOPTOTIC PROCESS 4 28 5.73e-07 1.99e-05
135 REGULATION OF CELLULAR PROTEIN LOCALIZATION 10 552 6.019e-07 2.075e-05
136 RESPONSE TO NITROGEN COMPOUND 12 859 6.096e-07 2.086e-05
137 REGULATION OF PROTEIN INSERTION INTO MITOCHONDRIAL MEMBRANE INVOLVED IN APOPTOTIC SIGNALING PATHWAY 4 29 6.636e-07 2.237e-05
138 POSITIVE REGULATION OF PROTEIN INSERTION INTO MITOCHONDRIAL MEMBRANE INVOLVED IN APOPTOTIC SIGNALING PATHWAY 4 29 6.636e-07 2.237e-05
139 PROTEIN STABILIZATION 6 131 6.892e-07 2.3e-05
140 REGULATION OF MEMBRANE PERMEABILITY 5 70 6.92e-07 2.3e-05
141 NEGATIVE REGULATION OF CELL DEATH 12 872 7.147e-07 2.358e-05
142 NEGATIVE REGULATION OF CELL MATRIX ADHESION 4 30 7.643e-07 2.487e-05
143 RESPONSE TO X RAY 4 30 7.643e-07 2.487e-05
144 REGULATION OF MITOCHONDRION ORGANIZATION 7 218 8.364e-07 2.702e-05
145 POSITIVE REGULATION OF ORGANELLE ORGANIZATION 10 573 8.452e-07 2.712e-05
146 RESPONSE TO EXTRACELLULAR STIMULUS 9 441 8.886e-07 2.832e-05
147 INTRINSIC APOPTOTIC SIGNALING PATHWAY IN RESPONSE TO ENDOPLASMIC RETICULUM STRESS 4 32 9.994e-07 3.163e-05
148 REGULATION OF LEUKOCYTE APOPTOTIC PROCESS 5 79 1.268e-06 3.986e-05
149 RESPONSE TO ESTRADIOL 6 146 1.301e-06 4.064e-05
150 REGULATION OF DNA METABOLIC PROCESS 8 340 1.341e-06 4.159e-05
151 RESPONSE TO TRANSITION METAL NANOPARTICLE 6 148 1.409e-06 4.341e-05
152 REGULATION OF PROTEIN OLIGOMERIZATION 4 35 1.447e-06 4.402e-05
153 RESPONSE TO MINERALOCORTICOID 4 35 1.447e-06 4.402e-05
154 ORGAN REGENERATION 5 83 1.622e-06 4.88e-05
155 POSITIVE REGULATION OF CYCLIN DEPENDENT PROTEIN KINASE ACTIVITY 4 36 1.626e-06 4.88e-05
156 REGULATION OF HYDROLASE ACTIVITY 14 1327 1.703e-06 5.079e-05
157 REGULATION OF INTRACELLULAR TRANSPORT 10 621 1.747e-06 5.178e-05
158 POSITIVE REGULATION OF CELLULAR COMPONENT ORGANIZATION 13 1152 2.091e-06 6.159e-05
159 ACTIVATION OF MAPKKK ACTIVITY 3 11 2.112e-06 6.181e-05
160 REGULATION OF NEURON DEATH 7 252 2.199e-06 6.394e-05
161 REGULATION OF CELL MATRIX ADHESION 5 90 2.424e-06 7.006e-05
162 POSITIVE REGULATION OF INTRACELLULAR TRANSPORT 8 370 2.516e-06 7.226e-05
163 MITOCHONDRIAL MEMBRANE ORGANIZATION 5 92 2.703e-06 7.716e-05
164 ACTIVATION OF CYSTEINE TYPE ENDOPEPTIDASE ACTIVITY INVOLVED IN APOPTOTIC SIGNALING PATHWAY 3 13 3.648e-06 0.0001029
165 RESPONSE TO COBALT ION 3 13 3.648e-06 0.0001029
166 NEGATIVE REGULATION OF EXTRINSIC APOPTOTIC SIGNALING PATHWAY 5 98 3.693e-06 0.0001029
167 REGULATION OF RELEASE OF CYTOCHROME C FROM MITOCHONDRIA 4 44 3.694e-06 0.0001029
168 POSITIVE REGULATION OF P38MAPK CASCADE 3 14 4.636e-06 0.0001284
169 REGULATION OF EPITHELIAL CELL PROLIFERATION 7 285 4.951e-06 0.0001363
170 RESPONSE TO GAMMA RADIATION 4 50 6.201e-06 0.0001687
171 RESPONSE TO NUTRIENT 6 191 6.165e-06 0.0001687
172 REGULATION OF NEURON APOPTOTIC PROCESS 6 192 6.353e-06 0.0001719
173 NEGATIVE REGULATION OF PHOSPHORYLATION 8 422 6.624e-06 0.0001782
174 CELLULAR RESPONSE TO IONIZING RADIATION 4 52 7.264e-06 0.0001931
175 POSITIVE REGULATION OF INTRINSIC APOPTOTIC SIGNALING PATHWAY 4 52 7.264e-06 0.0001931
176 REGULATION OF CATABOLIC PROCESS 10 731 7.431e-06 0.0001965
177 NEGATIVE REGULATION OF CELL SUBSTRATE ADHESION 4 53 7.843e-06 0.0002062
178 REGULATION OF LYMPHOCYTE APOPTOTIC PROCESS 4 54 8.455e-06 0.000221
179 POSITIVE REGULATION OF CYSTEINE TYPE ENDOPEPTIDASE ACTIVITY INVOLVED IN APOPTOTIC SIGNALING PATHWAY 3 17 8.616e-06 0.0002227
180 POSITIVE REGULATION OF EXTRINSIC APOPTOTIC SIGNALING PATHWAY VIA DEATH DOMAIN RECEPTORS 3 17 8.616e-06 0.0002227
181 MITOCHONDRION ORGANIZATION 9 594 1.009e-05 0.0002593
182 POSITIVE REGULATION OF MITOCHONDRIAL MEMBRANE PERMEABILITY 3 18 1.032e-05 0.0002639
183 APOPTOTIC MITOCHONDRIAL CHANGES 4 57 1.051e-05 0.0002671
184 RESPONSE TO MECHANICAL STIMULUS 6 210 1.06e-05 0.0002681
185 DEVELOPMENTAL PROCESS INVOLVED IN REPRODUCTION 9 602 1.123e-05 0.0002823
186 NEGATIVE REGULATION OF PROTEOLYSIS 7 329 1.262e-05 0.0003157
187 NEGATIVE REGULATION OF RESPONSE TO STIMULUS 13 1360 1.283e-05 0.0003191
188 REGULATION OF ESTABLISHMENT OF PROTEIN LOCALIZATION TO MITOCHONDRION 5 128 1.363e-05 0.0003374
189 POSITIVE REGULATION OF LYMPHOCYTE APOPTOTIC PROCESS 3 20 1.437e-05 0.0003538
190 POSITIVE REGULATION OF MAPK CASCADE 8 470 1.449e-05 0.0003548
191 REGULATION OF ORGANELLE ORGANIZATION 12 1178 1.589e-05 0.000387
192 POSITIVE REGULATION OF RESPONSE TO DNA DAMAGE STIMULUS 4 64 1.669e-05 0.0004045
193 DNA REPAIR 8 480 1.686e-05 0.0004065
194 NEGATIVE REGULATION OF CELL COMMUNICATION 12 1192 1.788e-05 0.0004288
195 REGULATION OF MITOCHONDRIAL MEMBRANE PERMEABILITY INVOLVED IN APOPTOTIC PROCESS 3 22 1.935e-05 0.0004524
196 RESPONSE TO ENDOPLASMIC RETICULUM STRESS 6 233 1.911e-05 0.0004524
197 RELEASE OF CYTOCHROME C FROM MITOCHONDRIA 3 22 1.935e-05 0.0004524
198 NEGATIVE REGULATION OF TRANSFERASE ACTIVITY 7 351 1.916e-05 0.0004524
199 REGULATION OF CYSTEINE TYPE ENDOPEPTIDASE ACTIVITY INVOLVED IN APOPTOTIC SIGNALING PATHWAY 3 22 1.935e-05 0.0004524
200 CELL CYCLE G2 M PHASE TRANSITION 5 138 1.962e-05 0.0004564
201 POSITIVE REGULATION OF CELL CYCLE PHASE TRANSITION 4 68 2.124e-05 0.0004918
202 RESPONSE TO MAGNESIUM ION 3 23 2.221e-05 0.0005042
203 RESPONSE TO INCREASED OXYGEN LEVELS 3 23 2.221e-05 0.0005042
204 RESPONSE TO HYPEROXIA 3 23 2.221e-05 0.0005042
205 PROTEIN INSERTION INTO MEMBRANE 3 23 2.221e-05 0.0005042
206 REGULATION OF INTRINSIC APOPTOTIC SIGNALING PATHWAY 5 145 2.49e-05 0.0005625
207 REGULATION OF EXECUTION PHASE OF APOPTOSIS 3 24 2.534e-05 0.0005697
208 REGULATION OF PROTEASOMAL UBIQUITIN DEPENDENT PROTEIN CATABOLIC PROCESS 5 148 2.748e-05 0.0006147
209 NEGATIVE REGULATION OF KINASE ACTIVITY 6 250 2.84e-05 0.0006323
210 HISTONE PHOSPHORYLATION 3 25 2.875e-05 0.0006371
211 REGULATION OF P38MAPK CASCADE 3 26 3.245e-05 0.0007155
212 REGULATION OF CELLULAR LOCALIZATION 12 1277 3.539e-05 0.0007767
213 NEGATIVE REGULATION OF PHOSPHORUS METABOLIC PROCESS 8 541 3.96e-05 0.0008571
214 REGULATION OF PROTEIN CATABOLIC PROCESS 7 393 3.943e-05 0.0008571
215 NEGATIVE REGULATION OF PHOSPHATE METABOLIC PROCESS 8 541 3.96e-05 0.0008571
216 CELLULAR RESPONSE TO MECHANICAL STIMULUS 4 80 4.04e-05 0.0008702
217 POSITIVE REGULATION OF RELEASE OF CYTOCHROME C FROM MITOCHONDRIA 3 28 4.075e-05 0.0008737
218 REGULATION OF NUCLEAR DIVISION 5 163 4.362e-05 0.0009311
219 POSITIVE REGULATION OF HYDROLASE ACTIVITY 10 905 4.674e-05 0.0009931
220 REGULATION OF CELLULAR PROTEIN CATABOLIC PROCESS 6 274 4.739e-05 0.001002
221 POSITIVE REGULATION OF CELLULAR COMPONENT BIOGENESIS 7 406 4.845e-05 0.00102
222 POSITIVE REGULATION OF MITOCHONDRION ORGANIZATION 5 167 4.897e-05 0.001026
223 INTRINSIC APOPTOTIC SIGNALING PATHWAY IN RESPONSE TO DNA DAMAGE BY P53 CLASS MEDIATOR 3 30 5.033e-05 0.001037
224 NEGATIVE REGULATION OF B CELL ACTIVATION 3 30 5.033e-05 0.001037
225 REPRODUCTIVE SYSTEM DEVELOPMENT 7 408 4.998e-05 0.001037
226 RESPONSE TO CARBOHYDRATE 5 168 5.038e-05 0.001037
227 REGULATION OF CELL SUBSTRATE ADHESION 5 173 5.791e-05 0.001187
228 NEGATIVE REGULATION OF CYCLIN DEPENDENT PROTEIN KINASE ACTIVITY 3 32 6.128e-05 0.001251
229 PROTEIN CATABOLIC PROCESS 8 579 6.388e-05 0.001298
230 MITOCHONDRIAL TRANSPORT 5 177 6.455e-05 0.001306
231 REGULATION OF PROTEIN EXPORT FROM NUCLEUS 3 33 6.729e-05 0.001338
232 SIGNAL TRANSDUCTION IN ABSENCE OF LIGAND 3 33 6.729e-05 0.001338
233 EXTRINSIC APOPTOTIC SIGNALING PATHWAY IN ABSENCE OF LIGAND 3 33 6.729e-05 0.001338
234 REGULATION OF CELL AGING 3 33 6.729e-05 0.001338
235 REGULATION OF PROTEIN LOCALIZATION 10 950 7.027e-05 0.001391
236 REGULATION OF PROTEASOMAL PROTEIN CATABOLIC PROCESS 5 181 7.176e-05 0.001415
237 T CELL HOMEOSTASIS 3 34 7.368e-05 0.001428
238 PROTEIN DESTABILIZATION 3 34 7.368e-05 0.001428
239 PROTEIN KINASE B SIGNALING 3 34 7.368e-05 0.001428
240 NEGATIVE REGULATION OF EXTRINSIC APOPTOTIC SIGNALING PATHWAY VIA DEATH DOMAIN RECEPTORS 3 34 7.368e-05 0.001428
241 REGULATION OF CELLULAR COMPONENT BIOGENESIS 9 767 7.491e-05 0.001446
242 RHYTHMIC PROCESS 6 298 7.545e-05 0.001451
243 NEGATIVE REGULATION OF INTRACELLULAR SIGNAL TRANSDUCTION 7 437 7.696e-05 0.001474
244 NEGATIVE REGULATION OF PROTEIN PROCESSING 3 35 8.045e-05 0.001516
245 NEGATIVE REGULATION OF PROTEIN MATURATION 3 35 8.045e-05 0.001516
246 RESPONSE TO IRON ION 3 35 8.045e-05 0.001516
247 REGULATION OF RESPONSE TO REACTIVE OXYGEN SPECIES 3 35 8.045e-05 0.001516
248 CELLULAR RESPONSE TO EXTRACELLULAR STIMULUS 5 188 8.585e-05 0.001611
249 EXTRINSIC APOPTOTIC SIGNALING PATHWAY 4 99 9.299e-05 0.001738
250 NEGATIVE REGULATION OF PROTEIN MODIFICATION PROCESS 8 616 9.838e-05 0.001831
251 CELLULAR RESPONSE TO LIPID 7 457 0.0001018 0.001886
252 POSITIVE REGULATION OF PROTEIN COMPLEX ASSEMBLY 5 197 0.000107 0.001975
253 EXTRINSIC APOPTOTIC SIGNALING PATHWAY VIA DEATH DOMAIN RECEPTORS 3 39 0.0001116 0.002052
254 CELLULAR RESPONSE TO ORGANIC CYCLIC COMPOUND 7 465 0.0001133 0.002076
255 REGULATION OF GROWTH 8 633 0.0001188 0.002167
256 CELLULAR RESPONSE TO ESTROGEN STIMULUS 3 41 0.0001297 0.002358
257 PHOSPHATE CONTAINING COMPOUND METABOLIC PROCESS 14 1977 0.0001537 0.002782
258 REGULATION OF MAPK CASCADE 8 660 0.0001583 0.002855
259 LYMPHOCYTE ACTIVATION 6 342 0.0001603 0.00288
260 CELLULAR RESPONSE TO STEROID HORMONE STIMULUS 5 218 0.0001718 0.003075
261 REGULATION OF NUCLEOCYTOPLASMIC TRANSPORT 5 220 0.0001793 0.003197
262 RESPONSE TO ANTIBIOTIC 3 47 0.0001953 0.003469
263 REPRODUCTION 11 1297 0.0001991 0.003522
264 REGULATION OF B CELL ACTIVATION 4 121 0.0002019 0.003559
265 POSITIVE REGULATION OF ESTABLISHMENT OF PROTEIN LOCALIZATION 7 514 0.0002101 0.003689
266 RESPONSE TO BIOTIC STIMULUS 9 886 0.000223 0.003901
267 LYMPHOCYTE HOMEOSTASIS 3 50 0.0002349 0.004094
268 NEGATIVE REGULATION OF PROTEIN SERINE THREONINE KINASE ACTIVITY 4 126 0.0002358 0.004094
269 REGULATION OF TRANSPORT 13 1804 0.0002381 0.004118
270 NEGATIVE REGULATION OF GROWTH 5 236 0.0002483 0.004279
271 REGULATION OF MITOCHONDRIAL MEMBRANE POTENTIAL 3 54 0.0002953 0.005051
272 NEGATIVE REGULATION OF PEPTIDASE ACTIVITY 5 245 0.0002951 0.005051
273 PROTEIN UBIQUITINATION INVOLVED IN UBIQUITIN DEPENDENT PROTEIN CATABOLIC PROCESS 4 134 0.0002983 0.005084
274 REGULATION OF B CELL PROLIFERATION 3 55 0.0003118 0.005295
275 RESPONSE TO ETHANOL 4 136 0.0003156 0.00534
276 POSITIVE REGULATION OF DEVELOPMENTAL PROCESS 10 1142 0.000317 0.005344
277 CIRCADIAN RHYTHM 4 137 0.0003245 0.005452
278 POSITIVE REGULATION OF TRANSPORT 9 936 0.0003348 0.005604
279 POSITIVE REGULATION OF CATABOLIC PROCESS 6 395 0.0003478 0.005801
280 LEUKOCYTE CELL CELL ADHESION 5 255 0.0003546 0.005893
281 PROTEIN PHOSPHORYLATION 9 944 0.0003564 0.005902
282 DEOXYRIBONUCLEOTIDE BIOSYNTHETIC PROCESS 2 12 0.0003666 0.006049
283 MACROMOLECULAR COMPLEX ASSEMBLY 11 1398 0.0003809 0.006263
284 REGULATION OF EPITHELIAL CELL APOPTOTIC PROCESS 3 59 0.0003838 0.006284
285 CELL ACTIVATION 7 568 0.0003849 0.006284
286 REGULATION OF IMMUNE SYSTEM PROCESS 11 1403 0.0003927 0.006389
287 LEUKOCYTE HOMEOSTASIS 3 60 0.0004033 0.006538
288 MITOTIC CELL CYCLE ARREST 2 13 0.0004326 0.006917
289 REGULATION OF IRE1 MEDIATED UNFOLDED PROTEIN RESPONSE 2 13 0.0004326 0.006917
290 POSITIVE REGULATION OF ENDOPLASMIC RETICULUM UNFOLDED PROTEIN RESPONSE 2 13 0.0004326 0.006917
291 REGULATION OF HISTONE PHOSPHORYLATION 2 13 0.0004326 0.006917
292 RESPONSE TO TEMPERATURE STIMULUS 4 148 0.000435 0.006932
293 LEUKOCYTE ACTIVATION 6 414 0.0004463 0.007088
294 REGULATION OF MULTICELLULAR ORGANISMAL DEVELOPMENT 12 1672 0.0004554 0.007207
295 POSITIVE REGULATION OF CHROMOSOME ORGANIZATION 4 150 0.0004576 0.007218
296 REGULATION OF CELL DIVISION 5 272 0.0004761 0.007485
297 MITOCHONDRIAL DNA METABOLIC PROCESS 2 14 0.0005039 0.00779
298 REGULATION OF FIBRINOLYSIS 2 14 0.0005039 0.00779
299 POSITIVE REGULATION OF EXTRINSIC APOPTOTIC SIGNALING PATHWAY IN ABSENCE OF LIGAND 2 14 0.0005039 0.00779
300 DETERMINATION OF ADULT LIFESPAN 2 14 0.0005039 0.00779
301 REGULATION OF SMOOTH MUSCLE CELL APOPTOTIC PROCESS 2 14 0.0005039 0.00779
302 REGULATION OF RESPONSE TO OXIDATIVE STRESS 3 65 0.0005105 0.007865
303 REGULATION OF CHROMOSOME ORGANIZATION 5 278 0.0005258 0.008074
304 ACTIVATION OF PROTEIN KINASE ACTIVITY 5 279 0.0005344 0.00818
305 REGULATION OF SISTER CHROMATID SEGREGATION 3 67 0.000558 0.008512
306 PHOSPHORYLATION 10 1228 0.0005634 0.008566
307 REGULATION OF JNK CASCADE 4 159 0.00057 0.008639
308 PROTEIN OLIGOMERIZATION 6 434 0.0005724 0.008647
309 DENTATE GYRUS DEVELOPMENT 2 15 0.0005805 0.008652
310 NEGATIVE REGULATION OF B CELL PROLIFERATION 2 15 0.0005805 0.008652
311 RESPONSE TO VITAMIN E 2 15 0.0005805 0.008652
312 NEGATIVE REGULATION OF DEVELOPMENTAL PROCESS 8 801 0.000582 0.008652
313 T CELL APOPTOTIC PROCESS 2 15 0.0005805 0.008652
314 POSITIVE REGULATION OF GENE EXPRESSION 12 1733 0.0006296 0.009329
315 PROTEIN LOCALIZATION TO MITOCHONDRION 3 70 0.0006344 0.009371
316 POSITIVE REGULATION OF CELL PROLIFERATION 8 814 0.000647 0.009527
317 REGULATION OF MAMMARY GLAND EPITHELIAL CELL PROLIFERATION 2 16 0.0006625 0.009633
318 NEGATIVE REGULATION OF ADHERENS JUNCTION ORGANIZATION 2 16 0.0006625 0.009633
319 LEUKOCYTE DIFFERENTIATION 5 292 0.0006567 0.009633
320 REGULATION OF PROTEIN HOMOOLIGOMERIZATION 2 16 0.0006625 0.009633
NumGOOverlapSizeP ValueAdj. P Value
1 CYCLIN DEPENDENT PROTEIN SERINE THREONINE KINASE REGULATOR ACTIVITY 6 28 5.003e-11 4.647e-08
2 KINASE BINDING 12 606 1.381e-08 6.416e-06
3 ENZYME BINDING 18 1737 4.195e-08 1.299e-05
4 P53 BINDING 5 67 5.552e-07 0.0001289
5 PROTEIN COMPLEX BINDING 12 935 1.489e-06 0.0002305
6 CYCLIN DEPENDENT PROTEIN KINASE ACTIVITY 4 34 1.284e-06 0.0002305
7 KINASE REGULATOR ACTIVITY 6 186 5.294e-06 0.0007026
8 CYCLIN BINDING 3 19 1.224e-05 0.001421
9 PROTEIN KINASE ACTIVITY 9 640 1.826e-05 0.001697
10 MACROMOLECULAR COMPLEX BINDING 13 1399 1.735e-05 0.001697
11 KINASE ACTIVITY 10 842 2.531e-05 0.002137
12 ENZYME REGULATOR ACTIVITY 10 959 7.602e-05 0.005885
13 PROTEIN SERINE THREONINE KINASE ACTIVITY 7 445 8.62e-05 0.00616
14 TRANSFERASE ACTIVITY TRANSFERRING PHOSPHORUS CONTAINING GROUPS 10 992 0.0001007 0.006683
NumGOOverlapSizeP ValueAdj. P Value
1 CYCLIN DEPENDENT PROTEIN KINASE HOLOENZYME COMPLEX 7 31 7.31e-13 4.269e-10
2 PROTEIN KINASE COMPLEX 7 90 1.868e-09 5.454e-07
3 CATALYTIC COMPLEX 13 1038 6.498e-07 0.0001265
4 TRANSFERASE COMPLEX TRANSFERRING PHOSPHORUS CONTAINING GROUPS 7 237 1.462e-06 0.0002135
5 TRANSFERASE COMPLEX 9 703 3.818e-05 0.004459

Over-represented Pathway

NumPathwayPathviewOverlapSizeP ValueAdj. P Value
1 hsa04115_p53_signaling_pathway 48 69 1.259e-128 2.266e-126
2 hsa04110_Cell_cycle 17 128 6.058e-26 5.452e-24
3 hsa04151_PI3K_AKT_signaling_pathway 13 351 1.332e-12 7.993e-11
4 hsa04210_Apoptosis 7 89 1.726e-09 7.766e-08
5 hsa04390_Hippo_signaling_pathway 6 154 1.776e-06 6.394e-05
6 hsa04510_Focal_adhesion 6 200 8.025e-06 0.0002407
7 hsa04114_Oocyte_meiosis 4 114 0.0001606 0.004128
8 hsa04120_Ubiquitin_mediated_proteolysis 4 139 0.0003429 0.007716
9 hsa04310_Wnt_signaling_pathway 4 151 0.0004693 0.009385
10 hsa04010_MAPK_signaling_pathway 4 268 0.003862 0.06952
11 hsa04630_Jak.STAT_signaling_pathway 3 155 0.006118 0.09631
12 hsa00480_Glutathione_metabolism 2 50 0.00642 0.09631
13 hsa04914_Progesterone.mediated_oocyte_maturation 2 87 0.01854 0.2566
14 hsa00240_Pyrimidine_metabolism 2 99 0.0236 0.3035
15 hsa04722_Neurotrophin_signaling_pathway 2 127 0.03732 0.4478
16 hsa04530_Tight_junction 2 133 0.04058 0.4565
17 hsa00230_Purine_metabolism 2 162 0.05772 0.6111

lncRNA-mediated sponge

(Download full result)

Num lncRNA miRNAs           miRNAs count     Gene Sponge regulatory network lncRNA log2FC lncRNA pvalue Gene log2FC Gene pvalue lncRNA-gene Pearson correlation
1

MEG3

 hsa-let-7d-5p;hsa-miR-151a-3p;hsa-miR-16-1-3p;hsa-miR-17-5p;hsa-miR-182-5p;hsa-miR-18a-5p;hsa-miR-19a-3p;hsa-miR-19b-3p;hsa-miR-200a-5p;hsa-miR-200b-5p;hsa-miR-20a-5p;hsa-miR-335-3p;hsa-miR-33a-3p;hsa-miR-577;hsa-miR-616-5p;hsa-miR-629-3p;hsa-miR-7-1-3p 17 THBS1 Sponge network -1.645 0.00049 -1.249 0.00266 0.524
2

MEG3

 hsa-miR-130b-3p;hsa-miR-15b-3p;hsa-miR-16-1-3p;hsa-miR-19a-3p;hsa-miR-19b-1-5p;hsa-miR-19b-3p;hsa-miR-20a-3p;hsa-miR-320b;hsa-miR-33a-3p;hsa-miR-3662;hsa-miR-577;hsa-miR-592;hsa-miR-629-5p 13 IGF1 Sponge network -1.645 0.00049 -2.083 0.00135 0.434
3

PART1

 hsa-miR-17-5p;hsa-miR-181b-5p;hsa-miR-186-5p;hsa-miR-192-3p;hsa-miR-19b-1-5p;hsa-miR-20a-5p;hsa-miR-29a-5p;hsa-miR-29b-1-5p;hsa-miR-335-3p;hsa-miR-338-5p;hsa-miR-550a-5p;hsa-miR-577;hsa-miR-625-3p;hsa-miR-625-5p;hsa-miR-7-1-3p;hsa-miR-877-5p 16 SESN3 Sponge network -2.298 0.00168 0.054 0.92794 0.407
4

PCA3

 hsa-let-7a-3p;hsa-let-7b-3p;hsa-let-7f-1-3p;hsa-miR-103a-2-5p;hsa-miR-130b-3p;hsa-miR-15b-3p;hsa-miR-16-1-3p;hsa-miR-181b-5p;hsa-miR-186-5p;hsa-miR-19a-3p;hsa-miR-19b-1-5p;hsa-miR-19b-3p;hsa-miR-20a-3p;hsa-miR-27a-3p;hsa-miR-301a-3p;hsa-miR-32-3p;hsa-miR-320b;hsa-miR-33a-3p;hsa-miR-3662;hsa-miR-454-3p;hsa-miR-576-5p;hsa-miR-590-3p;hsa-miR-629-5p;hsa-miR-940 24 IGF1 Sponge network -2.778 8.0E-5 -2.083 0.00135 0.404
5

AGAP11

 hsa-miR-106b-5p;hsa-miR-17-5p;hsa-miR-181b-5p;hsa-miR-192-3p;hsa-miR-19b-1-5p;hsa-miR-200a-5p;hsa-miR-200b-5p;hsa-miR-20a-5p;hsa-miR-25-3p;hsa-miR-26b-3p;hsa-miR-29a-5p;hsa-miR-29b-1-5p;hsa-miR-320b;hsa-miR-335-3p 14 SESN3 Sponge network -1.728 0.00016 0.054 0.92794 0.346
6

AGAP11

 hsa-let-7f-1-3p;hsa-miR-103a-2-5p;hsa-miR-130b-3p;hsa-miR-15b-3p;hsa-miR-16-1-3p;hsa-miR-181b-5p;hsa-miR-19a-3p;hsa-miR-19b-1-5p;hsa-miR-19b-3p;hsa-miR-20a-3p;hsa-miR-320b;hsa-miR-3662;hsa-miR-421;hsa-miR-629-5p 14 IGF1 Sponge network -1.728 0.00016 -2.083 0.00135 0.332
7

PCA3

 hsa-let-7a-3p;hsa-let-7b-3p;hsa-miR-106b-5p;hsa-miR-130b-5p;hsa-miR-141-3p;hsa-miR-15b-5p;hsa-miR-16-2-3p;hsa-miR-16-5p;hsa-miR-181a-2-3p;hsa-miR-182-5p;hsa-miR-183-5p;hsa-miR-19b-3p;hsa-miR-224-3p;hsa-miR-301a-3p;hsa-miR-3065-3p;hsa-miR-424-5p;hsa-miR-590-3p;hsa-miR-590-5p;hsa-miR-93-5p;hsa-miR-96-5p 20 CCND2 Sponge network -2.778 8.0E-5 -0.496 0.3 0.318
8

PCA3

 hsa-let-7a-3p;hsa-let-7d-5p;hsa-miR-16-1-3p;hsa-miR-17-5p;hsa-miR-182-5p;hsa-miR-186-5p;hsa-miR-18a-5p;hsa-miR-19a-3p;hsa-miR-19b-3p;hsa-miR-200a-5p;hsa-miR-200b-5p;hsa-miR-20a-5p;hsa-miR-33a-3p;hsa-miR-576-5p;hsa-miR-590-3p;hsa-miR-590-5p;hsa-miR-616-5p;hsa-miR-629-3p;hsa-miR-940 19 THBS1 Sponge network -2.778 8.0E-5 -1.249 0.00266 0.302
9

RFPL1S

 hsa-miR-106b-5p;hsa-miR-126-5p;hsa-miR-192-3p;hsa-miR-19b-1-5p;hsa-miR-200a-5p;hsa-miR-200b-3p;hsa-miR-200b-5p;hsa-miR-26b-3p;hsa-miR-29a-5p;hsa-miR-29b-1-5p;hsa-miR-30d-3p;hsa-miR-320b;hsa-miR-335-5p;hsa-miR-429;hsa-miR-550a-5p;hsa-miR-625-5p;hsa-miR-7-1-3p;hsa-miR-877-5p 18 SESN3 Sponge network -0.223 0.70704 0.054 0.92794 0.298
10

EMX2OS

 hsa-let-7d-5p;hsa-miR-151a-3p;hsa-miR-17-5p;hsa-miR-182-5p;hsa-miR-18a-5p;hsa-miR-19a-3p;hsa-miR-200a-5p;hsa-miR-200b-5p;hsa-miR-20a-5p;hsa-miR-335-3p;hsa-miR-577;hsa-miR-7-1-3p;hsa-miR-92a-3p 13 THBS1 Sponge network -1.088 0.10042 -1.249 0.00266 0.277

Quest ID: eb9e0fe878cf4853c58b27567800b10f