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This regulatory network was inferred from the input dataset. The miRNAs and mRNAs are presented as round and rectangle nodes respectively. The numerical value popped up upon mouse over the gene node is the log2 transformed fold-change of the gene expression between the two groups. All of the nodes are clickable, and the detailed information of the miRNAs/mRNAs and related cancer pathway will be displayed in another window. The edges between nodes are supported by both interactions (predicted or experimentally verified) and correlations learnt from cancer dataset. The numerical value popped up upon mouse over the edge is the correlation beat value (effect size) between the two nodes. The experimental evidences of the edges reported in previous cancer studies are highlighted by red/orange color. All of these information can be accessed by the "mouse-over" action. This network shows a full map of the miRNA-mRNA regulation of the input gene list(s), and the hub miRNAs (with the high network degree/betweenness centrality) would be the potential cancer drivers or tumor suppressors. The full result table can be accessed in the "Regulations" tab.

"miRNACancerMAP" is also a network visualization tool for users to draw their regulatory network by personal customization. Users can set the complexity of the network by limiting the number of nodes or edges. And the color of the nodes can be defined by different categories of the mRNAs and miRNAs, such as Gene-Ontology, pathway, and expression status. Users can also select to use network degree or network betweenness centrality to define the node size. And edges can be black or colored by the correlation. Purple edge means negative correlation (mostly found between miRNA and mRNA), and blue edge means positive correlation (found in PPI or miRNA-miRNA sponge effect). We can also add the protein-protein interactions (PPI) into the network. This result will show the cluster of genes regulated by some specific miRNAs. Additionally, miRNA-miRNA edges can be added by the "miRNA sponge" button, presenting some clusters of miRNAs that have the interactions via sponge effect.

miRNA-gene regulations

(Download full result)

Num microRNA           Gene miRNA log2FC miRNA pvalue Gene log2FC Gene pvalue Interaction Correlation beta Correlation P-value PMID Reported in cancer studies
1 hsa-miR-21-5p AKT2 1.51 0 -0.34 1.0E-5 miRNAWalker2 validate -0.25 0 NA
2 hsa-miR-330-5p AKT2 0.44 0.00533 -0.34 1.0E-5 miRanda -0.1 1.0E-5 NA
3 hsa-miR-342-3p AKT2 -0.32 0.04498 -0.34 1.0E-5 mirMAP -0.12 0 NA
4 hsa-miR-106b-5p AKT3 0.65 0 -0.66 0.00047 miRNATAP -0.26 0.00148 NA
5 hsa-miR-107 AKT3 0.24 0.01708 -0.66 0.00047 PITA; miRanda -0.6 0 NA
6 hsa-miR-122-5p AKT3 -1.24 0 -0.66 0.00047 miRNAWalker2 validate; miRTarBase -0.28 0 24244539 miR 122 regulates tumorigenesis in hepatocellular carcinoma by targeting AKT3; Here we identify AKT3 as a novel and direct target of miR-122; Restoration of miR-122 expression in HCC cell lines decreases AKT3 levels inhibits cell migration and proliferation and induces apoptosis; These anti-tumor phenotypes can be rescued by reconstitution of AKT3 expression indicating the essential role of AKT3 in miR-122 mediated HCC transformation; Our data strongly suggest that miR-122 is a tumor suppressor that targets AKT3 to regulate tumorigenesis in HCCs and a potential therapeutic candidate for liver cancer
7 hsa-miR-146b-5p AKT3 0.42 0.04574 -0.66 0.00047 miRNAWalker2 validate -0.16 0.00026 NA
8 hsa-miR-15a-5p AKT3 0.35 0.00077 -0.66 0.00047 miRNAWalker2 validate; miRTarBase; miRNATAP -0.27 0.00291 NA
9 hsa-miR-17-3p AKT3 0.41 0.00422 -0.66 0.00047 miRNATAP -0.35 0 NA
10 hsa-miR-17-5p AKT3 0.7 2.0E-5 -0.66 0.00047 TargetScan; miRNATAP -0.29 0 NA
11 hsa-miR-20a-5p AKT3 0.85 0 -0.66 0.00047 miRNATAP -0.29 0 NA
12 hsa-miR-32-3p AKT3 0.22 0.20722 -0.66 0.00047 mirMAP -0.23 4.0E-5 NA
13 hsa-miR-33a-3p AKT3 -0.68 1.0E-5 -0.66 0.00047 mirMAP -0.23 0.0001 NA
14 hsa-miR-362-3p AKT3 0.81 0 -0.66 0.00047 miRanda -0.22 0.00083 NA
15 hsa-miR-362-5p AKT3 0.72 2.0E-5 -0.66 0.00047 PITA; TargetScan; miRNATAP -0.15 0.00734 NA
16 hsa-miR-374a-5p AKT3 0.02 0.86978 -0.66 0.00047 mirMAP -0.28 0.00294 NA
17 hsa-miR-502-3p AKT3 0.66 0 -0.66 0.00047 miRNATAP -0.26 0.0008 NA
18 hsa-miR-616-5p AKT3 0.15 0.40284 -0.66 0.00047 mirMAP -0.2 0.0001 NA
19 hsa-miR-93-5p AKT3 1.4 0 -0.66 0.00047 miRNATAP -0.28 1.0E-5 NA
20 hsa-miR-15a-5p CAB39 0.35 0.00077 -0.15 0.00963 miRNATAP -0.11 8.0E-5 NA
21 hsa-miR-16-1-3p CAB39 0.39 0.00112 -0.15 0.00963 MirTarget -0.12 0 NA
22 hsa-miR-193a-3p CAB39 -0.12 0.30939 -0.15 0.00963 MirTarget; miRanda -0.12 0 NA
23 hsa-miR-192-3p CAB39L -0.64 0.00027 -0.5 1.0E-5 mirMAP -0.12 0.00012 NA
24 hsa-miR-192-5p CAB39L -0.5 0.00345 -0.5 1.0E-5 miRNAWalker2 validate -0.17 0 NA
25 hsa-miR-361-5p CAB39L 0.23 0.00962 -0.5 1.0E-5 MirTarget; miRanda -0.2 0.00208 NA
26 hsa-miR-362-3p CAB39L 0.81 0 -0.5 1.0E-5 miRanda -0.15 0.00018 NA
27 hsa-miR-618 CAB39L 0.14 0.51715 -0.5 1.0E-5 mirMAP -0.1 0.0003 NA
28 hsa-miR-30d-5p DDIT4 0.72 0 0.23 0.23684 MirTarget; miRNATAP -0.21 0.00439 NA
29 hsa-miR-32-5p DDIT4 0.08 0.54898 0.23 0.23684 miRNATAP -0.2 0.00446 NA
30 hsa-miR-92a-3p DDIT4 0.21 0.13429 0.23 0.23684 miRNATAP -0.18 0.00604 NA
31 hsa-miR-330-5p EIF4B 0.44 0.00533 -0.21 0.00928 miRNATAP -0.12 0 NA
32 hsa-miR-339-5p EIF4B 0.28 0.03557 -0.21 0.00928 miRanda -0.13 1.0E-5 NA
33 hsa-miR-342-3p EIF4B -0.32 0.04498 -0.21 0.00928 miRanda -0.13 0 NA
34 hsa-miR-362-3p EIF4B 0.81 0 -0.21 0.00928 miRanda -0.12 3.0E-5 NA
35 hsa-miR-484 EIF4B 0.09 0.45398 -0.21 0.00928 miRNAWalker2 validate -0.16 1.0E-5 NA
36 hsa-miR-497-5p EIF4B -1.41 0 -0.21 0.00928 miRNATAP -0.1 0 NA
37 hsa-miR-107 EIF4E 0.24 0.01708 -0.42 0 miRanda -0.15 5.0E-5 NA
38 hsa-miR-25-3p EIF4E 0.63 0 -0.42 0 mirMAP -0.12 0.00065 NA
39 hsa-miR-500a-3p EIF4E 1.19 0 -0.42 0 MirTarget -0.1 3.0E-5 NA
40 hsa-miR-660-5p EIF4E 0.99 0 -0.42 0 mirMAP -0.16 0 NA
41 hsa-miR-140-5p EIF4E2 -0.22 0.01407 -0.03 0.66056 miRanda -0.14 0.00026 NA
42 hsa-miR-29a-3p EIF4E2 -0.86 0 -0.03 0.66056 MirTarget -0.11 2.0E-5 NA
43 hsa-miR-125b-5p EIF4EBP1 -1.36 0 -0.03 0.83808 miRNAWalker2 validate; miRTarBase; MirTarget; miRNATAP -0.12 0.00778 17891175; 26646586 Using a bioinformatics approach we have identified additional potential mRNA targets of one of the miRNAs miR-125b that are upregulated in prostate cancer and confirmed increased expression of one of these targets EIF4EBP1 in prostate cancer tissues;Increased expression of miR-125a and miR-125b inhibited invasion and migration of SKOV3 and OVCAR-429 ovarian cancer cells and was associated with a decrease in EIF4EBP1 expression
44 hsa-miR-107 HIF1A 0.24 0.01708 -0.37 0.0111 miRNAWalker2 validate; miRTarBase; miRanda -0.44 0 NA
45 hsa-miR-17-5p HIF1A 0.7 2.0E-5 -0.37 0.0111 miRTarBase; MirTarget; TargetScan -0.21 0 NA
46 hsa-miR-20a-5p HIF1A 0.85 0 -0.37 0.0111 miRNAWalker2 validate; miRTarBase; MirTarget -0.25 0 22901144 Correlation analysis showed that the key miRNAs miR-20a and miR-20b negatively correlated with the target proteins VEGF-A and HIF-1alpha
47 hsa-miR-33a-5p HIF1A -0.77 1.0E-5 -0.37 0.0111 miRNAWalker2 validate -0.11 0.0073 NA
48 hsa-miR-616-5p HIF1A 0.15 0.40284 -0.37 0.0111 MirTarget -0.12 0.00144 NA
49 hsa-miR-660-5p HIF1A 0.99 0 -0.37 0.0111 MirTarget -0.25 0 NA
50 hsa-miR-93-5p HIF1A 1.4 0 -0.37 0.0111 MirTarget -0.17 0.00043 NA
51 hsa-miR-103a-2-5p IGF1 1.17 0 -3.09 0 mirMAP -0.26 0.00223 NA
52 hsa-miR-15b-3p IGF1 0.24 0.09977 -3.09 0 mirMAP -0.32 0.00625 NA
53 hsa-miR-181a-5p IGF1 0.25 0.05519 -3.09 0 mirMAP -0.5 9.0E-5 NA
54 hsa-miR-181b-5p IGF1 0.49 0.00105 -3.09 0 mirMAP -0.62 0 NA
55 hsa-miR-19a-3p IGF1 1.02 0 -3.09 0 MirTarget -0.4 0 NA
56 hsa-miR-19b-3p IGF1 0.6 0.00017 -3.09 0 MirTarget -0.48 0 NA
57 hsa-miR-20a-3p IGF1 -0.32 0.04679 -3.09 0 mirMAP -0.36 0.00055 NA
58 hsa-miR-301a-3p IGF1 0.84 0 -3.09 0 MirTarget -0.64 0 NA
59 hsa-miR-3913-5p IGF1 0.25 0.0628 -3.09 0 mirMAP -0.35 0.0061 NA
60 hsa-miR-421 IGF1 0.94 0 -3.09 0 PITA -0.47 0 NA
61 hsa-miR-454-3p IGF1 0.67 0 -3.09 0 MirTarget -0.66 0 NA
62 hsa-miR-940 IGF1 0.45 0.01771 -3.09 0 MirTarget; PITA; miRNATAP -0.26 0.0042 NA
63 hsa-miR-106a-5p PDPK1 -0.46 0.00972 0.31 0.01459 mirMAP -0.11 0.00192 NA
64 hsa-miR-22-5p PDPK1 -0.63 3.0E-5 0.31 0.01459 miRNATAP -0.11 0.00454 NA
65 hsa-miR-24-3p PDPK1 -0.26 0.0069 0.31 0.01459 miRNAWalker2 validate -0.19 0.00378 NA
66 hsa-miR-27a-3p PDPK1 -0.37 0.00876 0.31 0.01459 miRNATAP -0.13 0.00358 NA
67 hsa-miR-324-3p PDPK1 0.26 0.05061 0.31 0.01459 mirMAP -0.13 0.00407 NA
68 hsa-miR-326 PDPK1 -1.88 0 0.31 0.01459 mirMAP -0.12 0.00012 NA
69 hsa-miR-330-3p PDPK1 -0.33 0.03161 0.31 0.01459 mirMAP -0.2 0 NA
70 hsa-miR-330-5p PDPK1 0.44 0.00533 0.31 0.01459 mirMAP -0.17 1.0E-5 NA
71 hsa-miR-331-3p PDPK1 -0.28 0.03738 0.31 0.01459 miRNAWalker2 validate -0.14 0.00153 NA
72 hsa-miR-342-3p PDPK1 -0.32 0.04498 0.31 0.01459 mirMAP -0.2 0 NA
73 hsa-miR-424-5p PDPK1 -2.63 0 0.31 0.01459 mirMAP -0.11 0.00061 NA
74 hsa-miR-542-3p PDPK1 -1.31 0 0.31 0.01459 mirMAP -0.15 0.00056 NA
75 hsa-miR-744-5p PDPK1 -0.38 0.00125 0.31 0.01459 miRNAWalker2 validate -0.14 0.0067 NA
76 hsa-miR-766-3p PDPK1 0.2 0.25723 0.31 0.01459 mirMAP -0.15 1.0E-5 NA
77 hsa-miR-17-5p PIK3CA 0.7 2.0E-5 -0.42 0.00014 miRNAWalker2 validate -0.14 1.0E-5 NA
78 hsa-miR-339-5p PIK3CA 0.28 0.03557 -0.42 0.00014 miRanda -0.16 6.0E-5 NA
79 hsa-miR-501-5p PIK3CA 1.15 0 -0.42 0.00014 mirMAP -0.11 0.00012 NA
80 hsa-miR-126-5p PIK3CB -0.43 7.0E-5 0.1 0.16595 mirMAP -0.18 0 NA
81 hsa-miR-204-5p PIK3CB -0.54 0.03309 0.1 0.16595 miRNATAP -0.11 0 NA
82 hsa-miR-32-5p PIK3CB 0.08 0.54898 0.1 0.16595 miRNATAP -0.14 0 NA
83 hsa-miR-1468-5p PIK3CD -1.21 0 -0.88 0 MirTarget -0.11 0.00956 NA
84 hsa-miR-30b-3p PIK3CD -0.44 0.00095 -0.88 0 MirTarget -0.24 0.00045 NA
85 hsa-miR-30d-5p PIK3CD 0.72 0 -0.88 0 MirTarget; miRNATAP -0.31 1.0E-5 NA
86 hsa-miR-30e-5p PIK3CD -0.63 0 -0.88 0 MirTarget -0.25 0.00529 NA
87 hsa-miR-616-5p PIK3CD 0.15 0.40284 -0.88 0 MirTarget -0.21 5.0E-5 NA
88 hsa-miR-103a-3p PIK3R1 0.77 0 -0.89 0 MirTarget; miRNATAP -0.19 0.00703 NA
89 hsa-miR-106b-5p PIK3R1 0.65 0 -0.89 0 MirTarget; miRNATAP -0.37 0 NA
90 hsa-miR-1301-3p PIK3R1 1.12 0 -0.89 0 MirTarget -0.26 0 NA
91 hsa-miR-132-3p PIK3R1 0.32 0.00272 -0.89 0 MirTarget -0.52 0 NA
92 hsa-miR-17-5p PIK3R1 0.7 2.0E-5 -0.89 0 MirTarget; TargetScan; miRNATAP -0.21 0 NA
93 hsa-miR-185-5p PIK3R1 0.48 0 -0.89 0 miRNATAP -0.26 0.00154 NA
94 hsa-miR-188-5p PIK3R1 1.12 0 -0.89 0 MirTarget -0.18 5.0E-5 NA
95 hsa-miR-200c-3p PIK3R1 -0.1 0.71696 -0.89 0 mirMAP -0.11 9.0E-5 NA
96 hsa-miR-20a-5p PIK3R1 0.85 0 -0.89 0 MirTarget; miRNATAP -0.14 0.00238 NA
97 hsa-miR-21-5p PIK3R1 1.51 0 -0.89 0 miRNAWalker2 validate; MirTarget; miRNATAP -0.63 0 26676464 PIK3R1 targeting by miR 21 suppresses tumor cell migration and invasion by reducing PI3K/AKT signaling and reversing EMT and predicts clinical outcome of breast cancer; Next we identified the PIK3R1 as a direct target of miR-21 and showed that it was negatively regulated by miR-21; Taken together we provide novel evidence that miR-21 knockdown suppresses cell growth migration and invasion partly by inhibiting PI3K/AKT activation via direct targeting PIK3R1 and reversing EMT in breast cancer
98 hsa-miR-212-3p PIK3R1 -0.29 0.10039 -0.89 0 MirTarget -0.26 0 NA
99 hsa-miR-221-3p PIK3R1 1.12 0 -0.89 0 MirTarget -0.22 1.0E-5 NA
100 hsa-miR-222-3p PIK3R1 1.09 0 -0.89 0 MirTarget -0.26 0 NA
101 hsa-miR-324-3p PIK3R1 0.26 0.05061 -0.89 0 MirTarget; PITA; miRNATAP -0.28 0 NA
102 hsa-miR-330-3p PIK3R1 -0.33 0.03161 -0.89 0 MirTarget; PITA; miRNATAP -0.21 3.0E-5 NA
103 hsa-miR-338-5p PIK3R1 -0.22 0.25239 -0.89 0 PITA -0.14 0.00037 NA
104 hsa-miR-409-3p PIK3R1 -0.5 0.05268 -0.89 0 mirMAP -0.11 0.00024 NA
105 hsa-miR-493-5p PIK3R1 -0.2 0.50287 -0.89 0 MirTarget; miRNATAP -0.1 8.0E-5 NA
106 hsa-miR-582-5p PIK3R1 -0.68 0.00104 -0.89 0 mirMAP -0.14 0.00021 NA
107 hsa-miR-589-3p PIK3R1 1.17 0 -0.89 0 mirMAP -0.21 0 NA
108 hsa-miR-590-5p PIK3R1 -0.1 0.31003 -0.89 0 MirTarget; PITA; miRanda; miRNATAP -0.3 0.0001 NA
109 hsa-miR-629-3p PIK3R1 -0.32 0.11909 -0.89 0 MirTarget -0.18 0 NA
110 hsa-miR-93-5p PIK3R1 1.4 0 -0.89 0 MirTarget; miRNATAP -0.32 0 NA
111 hsa-miR-126-3p PIK3R2 -0.65 0 0.9 0 miRNAWalker2 validate; miRTarBase -0.31 0 25240815; 26384552; 27578985; 21249429; 26191164 MiR 126 3p suppresses tumor metastasis and angiogenesis of hepatocellular carcinoma by targeting LRP6 and PIK3R2; LRP6 and PIK3R2 were identified as targets of miR-126-3p; Silencing LRP6 and PIK3R2 had similar effects of miR-126-3p restoration on metastasis and angiogenesis individually in HCC cells; Furthermore the miR-126-3p level was inversely correlated with LRP6 and PIK3R2 in HCC tissues; In addition the rescue experiments indicated that the metastasis and angiogenesis functions of miR-126-3p were mediated by LRP6 and PIK3R2;MicroRNA 126 suppresses proliferation of undifferentiated BRAFV600E and BRAFWT thyroid carcinoma through targeting PIK3R2 gene and repressing PI3K AKT proliferation survival signalling pathway; In addition miR-126 was found to act as proliferation suppressor targeting PIK3R2 gene and reducing p85β a regulatory subunit of PI3K kinase protein translation and lower AKT kinase activity;MiR 126 regulates proliferation and invasion in the bladder cancer BLS cell line by targeting the PIK3R2 mediated PI3K/Akt signaling pathway; A direct regulatory relationship between miR-126 and the PIK3R2 gene was demonstrated by luciferase reporter assays; Quantitative real-time polymerase chain reaction was used to measure miR-126 and PIK3R2 expressions; Luciferase assays showed that miR-126 significantly inhibited the PIK3R2 3' untranslated region 3'UTR luciferase reporter activity P<0.05; Overexpression of miR-126 negatively regulated the target gene PIK3R2 and further inhibited the PI3K/Akt signaling pathway thereby inhibiting proliferation migration and invasion and promoting apoptosis in BLS cells;Endothelial specific intron derived miR 126 is down regulated in human breast cancer and targets both VEGFA and PIK3R2; VEGFA and PIK3R2 were confirmed as the targets of miR-126 by luciferase reporter assay and Western blot;Restoration of miR-126 in EC109 cells induced a reduction in PIK3R2 protein levels accompanied with a substantial reduction in phosphorylated AKT levels in EC109 cells suggesting impairment in PI3K/AKT signaling pathway; The luciferase reporter assay confirmed that PIK3R2 was a direct target of miR-126; Taken together our study suggests that miR-126 functions as a potential tumor suppressor in ESCC progression via regulating PI3K/AKT signaling pathway partly by targeting PIK3R2 and targeting of miR-126 may provide a novel strategy for the diagnosis and treatment of ESCC
112 hsa-miR-28-5p PIK3R2 -0.43 0 0.9 0 miRanda -0.22 0.00079 NA
113 hsa-miR-30a-5p PIK3R2 -0.63 0.00011 0.9 0 miRNATAP -0.14 7.0E-5 NA
114 hsa-miR-30e-5p PIK3R2 -0.63 0 0.9 0 miRNATAP -0.27 0 NA
115 hsa-miR-3607-3p PIK3R2 -2.16 0 0.9 0 mirMAP; miRNATAP -0.19 0 NA
116 hsa-miR-19a-3p PIK3R3 1.02 0 0.64 0 MirTarget; miRNATAP -0.1 0.00019 NA
117 hsa-miR-19b-3p PIK3R3 0.6 0.00017 0.64 0 MirTarget; miRNATAP -0.16 1.0E-5 NA
118 hsa-miR-222-5p PIK3R3 0.13 0.48742 0.64 0 mirMAP -0.12 7.0E-5 NA
119 hsa-miR-32-5p PIK3R3 0.08 0.54898 0.64 0 MirTarget; miRNATAP -0.12 0.00655 NA
120 hsa-miR-331-3p PIK3R3 -0.28 0.03738 0.64 0 miRNAWalker2 validate; PITA -0.14 0.00066 NA
121 hsa-miR-335-3p PIK3R3 -0.28 0.10663 0.64 0 mirMAP -0.16 0 NA
122 hsa-miR-454-3p PIK3R3 0.67 0 0.64 0 mirMAP -0.16 8.0E-5 NA
123 hsa-miR-590-5p PIK3R3 -0.1 0.31003 0.64 0 miRanda -0.24 1.0E-5 NA
124 hsa-miR-624-5p PIK3R3 -0.64 1.0E-5 0.64 0 MirTarget -0.12 0.00156 NA
125 hsa-miR-92a-3p PIK3R3 0.21 0.13429 0.64 0 MirTarget; miRNATAP -0.21 0 NA
126 hsa-miR-107 PIK3R5 0.24 0.01708 -0.9 0 miRanda -0.35 3.0E-5 NA
127 hsa-miR-15a-5p PRKAA1 0.35 0.00077 -0.61 0 MirTarget -0.13 0.0026 NA
128 hsa-let-7b-3p PRKAA2 -1.22 0 0.91 0.01333 mirMAP -0.39 0.00115 NA
129 hsa-let-7b-5p PRKAA2 -0.96 0 0.91 0.01333 miRNAWalker2 validate; MirTarget -0.4 0.00086 NA
130 hsa-let-7c-5p PRKAA2 -1.71 0 0.91 0.01333 MirTarget -0.32 0.00046 NA
131 hsa-miR-125b-5p PRKAA2 -1.36 0 0.91 0.01333 miRNATAP -0.47 3.0E-5 NA
132 hsa-miR-130a-3p PRKAA2 -1.53 0 0.91 0.01333 MirTarget -0.26 0.00937 NA
133 hsa-miR-130b-3p PRKAA2 0.69 0.00011 0.91 0.01333 MirTarget -0.39 9.0E-5 NA
134 hsa-miR-139-5p PRKAA2 -2.11 0 0.91 0.01333 mirMAP -0.24 0.005 NA
135 hsa-miR-144-3p PRKAA2 -2.98 0 0.91 0.01333 mirMAP -0.25 4.0E-5 NA
136 hsa-miR-16-2-3p PRKAA2 -0.03 0.80516 0.91 0.01333 mirMAP -0.46 0.00054 NA
137 hsa-miR-195-3p PRKAA2 -1.09 0 0.91 0.01333 mirMAP -0.53 0 NA
138 hsa-miR-203a-3p PRKAA2 -1.34 9.0E-5 0.91 0.01333 MirTarget -0.18 0.00054 NA
139 hsa-miR-217 PRKAA2 1.06 0.0401 0.91 0.01333 mirMAP -0.17 0 NA
140 hsa-miR-22-5p PRKAA2 -0.63 3.0E-5 0.91 0.01333 mirMAP -0.41 0.00052 NA
141 hsa-miR-26a-5p PRKAA2 -0.96 0 0.91 0.01333 mirMAP -0.78 1.0E-5 NA
142 hsa-miR-30e-3p PRKAA2 -1.21 0 0.91 0.01333 MirTarget -0.53 0.00029 NA
143 hsa-miR-628-3p PRKAA2 -0.96 0 0.91 0.01333 mirMAP -0.3 0.00298 NA
144 hsa-miR-542-3p RHEB -1.31 0 0.59 0 miRanda -0.15 0 NA
145 hsa-miR-16-1-3p RICTOR 0.39 0.00112 -0.24 0.0047 MirTarget -0.11 0.00155 NA
146 hsa-miR-660-5p RICTOR 0.99 0 -0.24 0.0047 MirTarget -0.12 4.0E-5 NA
147 hsa-miR-99a-5p RPS6 -1.51 0 0.19 0.12092 miRNAWalker2 validate -0.14 0 NA
148 hsa-miR-17-5p RPS6KA1 0.7 2.0E-5 -0.02 0.89527 TargetScan; miRNATAP -0.15 0.00044 NA
149 hsa-miR-20a-5p RPS6KA1 0.85 0 -0.02 0.89527 miRNATAP -0.14 0.00072 NA
150 hsa-miR-130b-5p RPS6KA2 0.17 0.33761 -0.43 0.0094 mirMAP -0.21 0 NA

Over-represented Gene Ontology Biological Process

NumGOOverlapSizeP ValueAdj. P Value
1 INTRACELLULAR SIGNAL TRANSDUCTION 24 1572 4.685e-19 2.18e-15
2 PHOSPHORYLATION 21 1228 3.062e-17 7.123e-14
3 PROTEIN PHOSPHORYLATION 18 944 2.449e-15 3.799e-12
4 INOSITOL LIPID MEDIATED SIGNALING 10 124 9.343e-15 1.087e-11
5 RESPONSE TO INSULIN 11 205 3.372e-14 2.615e-11
6 PHOSPHATE CONTAINING COMPOUND METABOLIC PROCESS 22 1977 2.874e-14 2.615e-11
7 REGULATION OF CELLULAR RESPONSE TO INSULIN STIMULUS 8 59 7.742e-14 5.146e-11
8 REGULATION OF PHOSPHORUS METABOLIC PROCESS 20 1618 1.282e-13 7.457e-11
9 REGULATION OF TOR SIGNALING 8 68 2.553e-13 1.32e-10
10 REGULATION OF CELLULAR AMIDE METABOLIC PROCESS 12 354 4.547e-13 2.116e-10
11 TRANSMEMBRANE RECEPTOR PROTEIN TYROSINE KINASE SIGNALING PATHWAY 13 498 1.085e-12 4.588e-10
12 CELLULAR RESPONSE TO INSULIN STIMULUS 9 146 2.757e-12 1.069e-09
13 PHOSPHATIDYLINOSITOL 3 KINASE SIGNALING 6 25 3.161e-12 1.131e-09
14 REGULATION OF GLUCOSE IMPORT 7 60 9.592e-12 3.188e-09
15 NEGATIVE REGULATION OF TOR SIGNALING 6 30 1.053e-11 3.267e-09
16 REGULATION OF CELL CYCLE 15 949 1.662e-11 4.832e-09
17 PROTEIN KINASE B SIGNALING 6 34 2.374e-11 6.497e-09
18 RESPONSE TO PEPTIDE 11 404 5.388e-11 1.393e-08
19 ENZYME LINKED RECEPTOR PROTEIN SIGNALING PATHWAY 13 689 6.315e-11 1.547e-08
20 REGULATION OF GLUCOSE IMPORT IN RESPONSE TO INSULIN STIMULUS 5 17 7.425e-11 1.727e-08
21 CELLULAR RESPONSE TO HORMONE STIMULUS 12 552 8.119e-11 1.799e-08
22 PEPTIDYL SERINE MODIFICATION 8 148 1.477e-10 3.124e-08
23 POSTTRANSCRIPTIONAL REGULATION OF GENE EXPRESSION 11 448 1.621e-10 3.202e-08
24 REGULATION OF GENERATION OF PRECURSOR METABOLITES AND ENERGY 7 89 1.651e-10 3.202e-08
25 CELL CYCLE ARREST 8 154 2.031e-10 3.78e-08
26 PHOSPHATIDYLINOSITOL 3 PHOSPHATE BIOSYNTHETIC PROCESS 6 49 2.422e-10 4.335e-08
27 REGULATION OF KINASE ACTIVITY 13 776 2.738e-10 4.719e-08
28 REGULATION OF GLUCOSE TRANSPORT 7 100 3.785e-10 6.29e-08
29 REGULATION OF INTRACELLULAR SIGNAL TRANSDUCTION 17 1656 3.995e-10 6.409e-08
30 POSITIVE REGULATION OF RESPONSE TO STIMULUS 18 1929 4.398e-10 6.822e-08
31 POSITIVE REGULATION OF PHOSPHATE METABOLIC PROCESS 14 1036 7.667e-10 1.055e-07
32 POSITIVE REGULATION OF PHOSPHORUS METABOLIC PROCESS 14 1036 7.667e-10 1.055e-07
33 REGULATION OF CELL DEATH 16 1472 7.256e-10 1.055e-07
34 CELLULAR RESPONSE TO PEPTIDE 9 274 7.71e-10 1.055e-07
35 NEGATIVE REGULATION OF CELL DEATH 13 872 1.14e-09 1.515e-07
36 PHOSPHATIDYLINOSITOL BIOSYNTHETIC PROCESS 7 120 1.372e-09 1.774e-07
37 RESPONSE TO HORMONE 13 893 1.522e-09 1.914e-07
38 NEGATIVE REGULATION OF CELL CYCLE 10 433 2.308e-09 2.827e-07
39 VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR SIGNALING PATHWAY 6 74 3.111e-09 3.542e-07
40 REGULATION OF TRANSFERASE ACTIVITY 13 946 3.059e-09 3.542e-07
41 RESPONSE TO OXYGEN CONTAINING COMPOUND 15 1381 3.121e-09 3.542e-07
42 REGULATION OF PHOSPHATIDYLINOSITOL 3 KINASE SIGNALING 7 138 3.656e-09 4.051e-07
43 POSITIVE REGULATION OF GLUCOSE IMPORT IN RESPONSE TO INSULIN STIMULUS 4 12 3.85e-09 4.167e-07
44 REGULATION OF NUCLEOTIDE CATABOLIC PROCESS 5 36 4.417e-09 4.671e-07
45 INSULIN RECEPTOR SIGNALING PATHWAY 6 80 5.008e-09 5.178e-07
46 CELLULAR RESPONSE TO OXYGEN CONTAINING COMPOUND 12 799 5.444e-09 5.507e-07
47 CELLULAR RESPONSE TO NITROGEN COMPOUND 10 505 1.004e-08 9.343e-07
48 REGULATION OF CELLULAR CARBOHYDRATE CATABOLIC PROCESS 5 42 9.892e-09 9.343e-07
49 POSITIVE REGULATION OF GLUCOSE TRANSPORT 5 42 9.892e-09 9.343e-07
50 REGULATION OF CARBOHYDRATE CATABOLIC PROCESS 5 42 9.892e-09 9.343e-07
51 RESPONSE TO NITROGEN COMPOUND 12 859 1.222e-08 1.115e-06
52 POSITIVE REGULATION OF IMMUNE SYSTEM PROCESS 12 867 1.355e-08 1.213e-06
53 TOR SIGNALING 4 16 1.409e-08 1.237e-06
54 GLUCOSE HOMEOSTASIS 7 170 1.559e-08 1.319e-06
55 CARBOHYDRATE HOMEOSTASIS 7 170 1.559e-08 1.319e-06
56 CELL CYCLE 14 1316 1.667e-08 1.385e-06
57 POSITIVE REGULATION OF NUCLEOTIDE CATABOLIC PROCESS 4 17 1.84e-08 1.476e-06
58 LIPID PHOSPHORYLATION 6 99 1.824e-08 1.476e-06
59 REGULATION OF NUCLEOSIDE METABOLIC PROCESS 5 49 2.198e-08 1.705e-06
60 REGULATION OF ATP METABOLIC PROCESS 5 49 2.198e-08 1.705e-06
61 REGULATION OF COENZYME METABOLIC PROCESS 5 50 2.439e-08 1.831e-06
62 REGULATION OF COFACTOR METABOLIC PROCESS 5 50 2.439e-08 1.831e-06
63 PHOSPHATIDYLINOSITOL METABOLIC PROCESS 7 193 3.739e-08 2.761e-06
64 REGULATION OF PEPTIDYL SERINE PHOSPHORYLATION 6 118 5.238e-08 3.808e-06
65 REGULATION OF PROTEIN MODIFICATION PROCESS 15 1710 5.613e-08 4.018e-06
66 LIPID MODIFICATION 7 210 6.671e-08 4.703e-06
67 POSITIVE REGULATION OF CELLULAR RESPONSE TO INSULIN STIMULUS 4 23 6.795e-08 4.715e-06
68 GLYCEROLIPID BIOSYNTHETIC PROCESS 7 211 6.891e-08 4.715e-06
69 CELLULAR RESPONSE TO ENDOGENOUS STIMULUS 12 1008 7.152e-08 4.823e-06
70 POSITIVE REGULATION OF NUCLEOSIDE METABOLIC PROCESS 4 24 8.144e-08 5.263e-06
71 POSITIVE REGULATION OF PROTEIN METABOLIC PROCESS 14 1492 8.11e-08 5.263e-06
72 POSITIVE REGULATION OF ATP METABOLIC PROCESS 4 24 8.144e-08 5.263e-06
73 RESPONSE TO ABIOTIC STIMULUS 12 1024 8.497e-08 5.416e-06
74 CELL MOTILITY 11 835 1.046e-07 6.323e-06
75 POSITIVE REGULATION OF CATALYTIC ACTIVITY 14 1518 1.006e-07 6.323e-06
76 POSITIVE REGULATION OF MOLECULAR FUNCTION 15 1791 1.038e-07 6.323e-06
77 LOCALIZATION OF CELL 11 835 1.046e-07 6.323e-06
78 RESPONSE TO ACTIVITY 5 69 1.263e-07 7.537e-06
79 RESPONSE TO EXTERNAL STIMULUS 15 1821 1.293e-07 7.616e-06
80 PHOSPHOLIPID BIOSYNTHETIC PROCESS 7 235 1.437e-07 8.358e-06
81 CELL CYCLE PROCESS 12 1081 1.533e-07 8.808e-06
82 CELLULAR RESPONSE TO ORGANIC SUBSTANCE 15 1848 1.57e-07 8.91e-06
83 T CELL RECEPTOR SIGNALING PATHWAY 6 146 1.861e-07 1.043e-05
84 POSITIVE REGULATION OF CARBOHYDRATE METABOLIC PROCESS 5 75 1.926e-07 1.067e-05
85 REGULATION OF AUTOPHAGY 7 249 2.129e-07 1.152e-05
86 LOCOMOTION 12 1114 2.124e-07 1.152e-05
87 POSITIVE REGULATION OF CELL ADHESION 8 376 2.188e-07 1.17e-05
88 NEGATIVE REGULATION OF CELLULAR RESPONSE TO INSULIN STIMULUS 4 31 2.391e-07 1.264e-05
89 POSITIVE REGULATION OF PROTEIN MODIFICATION PROCESS 12 1135 2.6e-07 1.359e-05
90 LIPID BIOSYNTHETIC PROCESS 9 539 2.652e-07 1.371e-05
91 REGULATION OF CATABOLIC PROCESS 10 731 3.206e-07 1.639e-05
92 CELL ACTIVATION 9 568 4.119e-07 2.083e-05
93 ACTIVATION OF PROTEIN KINASE ACTIVITY 7 279 4.591e-07 2.297e-05
94 RESPONSE TO ENDOGENOUS STIMULUS 13 1450 4.722e-07 2.337e-05
95 REGULATION OF CELL MATRIX ADHESION 5 90 4.813e-07 2.357e-05
96 REGULATION OF LIPID METABOLIC PROCESS 7 282 4.933e-07 2.366e-05
97 REGULATION OF CARBOHYDRATE METABOLIC PROCESS 6 172 4.893e-07 2.366e-05
98 POSITIVE REGULATION OF LOCOMOTION 8 420 5.067e-07 2.406e-05
99 POSITIVE REGULATION OF GENE EXPRESSION 14 1733 5.165e-07 2.428e-05
100 REGULATION OF PHOSPHATIDYLINOSITOL 3 KINASE ACTIVITY 4 40 6.866e-07 3.195e-05
101 GLYCEROPHOSPHOLIPID METABOLIC PROCESS 7 297 6.987e-07 3.219e-05
102 REGULATION OF TRANSPORT 14 1804 8.423e-07 3.843e-05
103 MOVEMENT OF CELL OR SUBCELLULAR COMPONENT 12 1275 9.038e-07 4.083e-05
104 RESPONSE TO OXYGEN LEVELS 7 311 9.511e-07 4.255e-05
105 REGULATION OF CELL ADHESION 9 629 9.652e-07 4.277e-05
106 ANTIGEN RECEPTOR MEDIATED SIGNALING PATHWAY 6 195 1.02e-06 4.479e-05
107 POSITIVE REGULATION OF KINASE ACTIVITY 8 482 1.426e-06 6.19e-05
108 REGULATION OF LIPID KINASE ACTIVITY 4 48 1.447e-06 6.19e-05
109 NEGATIVE REGULATION OF PROTEIN METABOLIC PROCESS 11 1087 1.45e-06 6.19e-05
110 IMMUNE EFFECTOR PROCESS 8 486 1.517e-06 6.416e-05
111 REGULATION OF NUCLEOTIDE METABOLIC PROCESS 6 211 1.615e-06 6.769e-05
112 INSULIN LIKE GROWTH FACTOR RECEPTOR SIGNALING PATHWAY 3 14 1.764e-06 7.327e-05
113 GLYCEROLIPID METABOLIC PROCESS 7 356 2.337e-06 9.623e-05
114 REGULATION OF IMMUNE SYSTEM PROCESS 12 1403 2.48e-06 0.0001012
115 PHOSPHOLIPID METABOLIC PROCESS 7 364 2.707e-06 0.0001095
116 NEGATIVE REGULATION OF CELLULAR AMIDE METABOLIC PROCESS 5 131 3.096e-06 0.0001242
117 REGULATION OF PHOSPHOLIPID METABOLIC PROCESS 4 61 3.82e-06 0.0001519
118 RESPONSE TO OSMOTIC STRESS 4 63 4.349e-06 0.0001715
119 RESPONSE TO WOUNDING 8 563 4.514e-06 0.0001765
120 PLATELET ACTIVATION 5 142 4.597e-06 0.0001768
121 FC EPSILON RECEPTOR SIGNALING PATHWAY 5 142 4.597e-06 0.0001768
122 CELLULAR RESPONSE TO OXYGEN LEVELS 5 143 4.758e-06 0.0001815
123 REGULATION OF CELLULAR COMPONENT MOVEMENT 9 771 5.14e-06 0.0001945
124 TRANSLATIONAL INITIATION 5 146 5.266e-06 0.0001963
125 LEUKOCYTE MIGRATION 6 259 5.272e-06 0.0001963
126 CELL DEATH 10 1001 5.506e-06 0.0002017
127 RESPONSE TO MUSCLE ACTIVITY 3 20 5.484e-06 0.0002017
128 REGULATION OF DNA TEMPLATED TRANSCRIPTION IN RESPONSE TO STRESS 4 67 5.569e-06 0.0002024
129 POSITIVE REGULATION OF NEUROBLAST PROLIFERATION 3 21 6.39e-06 0.0002305
130 POSITIVE REGULATION OF EPITHELIAL CELL PROLIFERATION 5 154 6.833e-06 0.0002446
131 ACTIVATION OF IMMUNE RESPONSE 7 427 7.72e-06 0.0002721
132 CELLULAR RESPONSE TO STRESS 12 1565 7.704e-06 0.0002721
133 POSITIVE REGULATION OF TRANSFERASE ACTIVITY 8 616 8.728e-06 0.0003014
134 CELLULAR GLUCOSE HOMEOSTASIS 4 75 8.744e-06 0.0003014
135 POSITIVE REGULATION OF AUTOPHAGY 4 75 8.744e-06 0.0003014
136 RESPONSE TO EXTRACELLULAR STIMULUS 7 441 9.525e-06 0.0003259
137 REGULATION OF POSITIVE CHEMOTAXIS 3 24 9.689e-06 0.0003291
138 POSITIVE REGULATION OF PROTEIN SERINE THREONINE KINASE ACTIVITY 6 289 9.862e-06 0.0003325
139 LYMPHOCYTE COSTIMULATION 4 78 1.022e-05 0.0003422
140 REGULATION OF GROWTH 8 633 1.064e-05 0.0003537
141 ORGANOPHOSPHATE BIOSYNTHETIC PROCESS 7 450 1.086e-05 0.0003584
142 REGULATION OF CELL SUBSTRATE ADHESION 5 173 1.202e-05 0.000394
143 REGULATION OF TRANSLATIONAL INITIATION 4 82 1.247e-05 0.0004059
144 REGULATION OF VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR SIGNALING PATHWAY 3 27 1.395e-05 0.0004508
145 CHEMICAL HOMEOSTASIS 9 874 1.412e-05 0.000453
146 WOUND HEALING 7 470 1.439e-05 0.0004587
147 POSITIVE REGULATION OF CELL ACTIVATION 6 311 1.496e-05 0.0004734
148 IMMUNE SYSTEM PROCESS 13 1984 1.57e-05 0.0004904
149 REGULATION OF NEUROBLAST PROLIFERATION 3 28 1.561e-05 0.0004904
150 NEGATIVE REGULATION OF CYSTEINE TYPE ENDOPEPTIDASE ACTIVITY 4 88 1.651e-05 0.0005121
151 EMBRYO DEVELOPMENT 9 894 1.691e-05 0.000521
152 IMMUNE RESPONSE REGULATING CELL SURFACE RECEPTOR SIGNALING PATHWAY 6 323 1.852e-05 0.000567
153 CELLULAR LIPID METABOLIC PROCESS 9 913 1.998e-05 0.0006078
154 FC GAMMA RECEPTOR SIGNALING PATHWAY 4 95 2.234e-05 0.000675
155 REGULATION OF BODY FLUID LEVELS 7 506 2.315e-05 0.0006949
156 POSITIVE REGULATION OF TRANSPORT 9 936 2.434e-05 0.000726
157 POSITIVE REGULATION OF ESTABLISHMENT OF PROTEIN LOCALIZATION 7 514 2.56e-05 0.0007586
158 FC RECEPTOR SIGNALING PATHWAY 5 206 2.788e-05 0.000821
159 POSITIVE CHEMOTAXIS 3 36 3.369e-05 0.000986
160 POSITIVE REGULATION OF CELLULAR PROTEIN LOCALIZATION 6 360 3.407e-05 0.0009907
161 POSITIVE REGULATION OF CELL COMMUNICATION 11 1532 3.833e-05 0.001108
162 CELL CYCLE G1 S PHASE TRANSITION 4 111 4.12e-05 0.001176
163 G1 S TRANSITION OF MITOTIC CELL CYCLE 4 111 4.12e-05 0.001176
164 POSITIVE REGULATION OF IMMUNE RESPONSE 7 563 4.572e-05 0.001297
165 POSITIVE REGULATION OF CELL MATRIX ADHESION 3 40 4.64e-05 0.001308
166 CARDIOVASCULAR SYSTEM DEVELOPMENT 8 788 5.12e-05 0.001427
167 CIRCULATORY SYSTEM DEVELOPMENT 8 788 5.12e-05 0.001427
168 POSITIVE REGULATION OF NEURAL PRECURSOR CELL PROLIFERATION 3 42 5.378e-05 0.00149
169 POSITIVE REGULATION OF GROWTH 5 238 5.55e-05 0.001528
170 AUTOPHAGY 6 394 5.631e-05 0.001541
171 RESPONSE TO ELECTRICAL STIMULUS 3 43 5.775e-05 0.001553
172 POSITIVE REGULATION OF CATABOLIC PROCESS 6 395 5.711e-05 0.001553
173 REGULATION OF INSULIN RECEPTOR SIGNALING PATHWAY 3 43 5.775e-05 0.001553
174 POSITIVE REGULATION OF MITOTIC CELL CYCLE 4 123 6.154e-05 0.001636
175 POSITIVE REGULATION OF CELL CELL ADHESION 5 243 6.125e-05 0.001636
176 SINGLE ORGANISM BIOSYNTHETIC PROCESS 10 1340 6.886e-05 0.001821
177 REGULATION OF NEURON DEATH 5 252 7.275e-05 0.001912
178 TUBE FORMATION 4 129 7.407e-05 0.001936
179 PEPTIDYL AMINO ACID MODIFICATION 8 841 8.093e-05 0.002104
180 POSITIVE REGULATION OF PURINE NUCLEOTIDE METABOLIC PROCESS 4 133 8.34e-05 0.002144
181 POSITIVE REGULATION OF NUCLEOTIDE METABOLIC PROCESS 4 133 8.34e-05 0.002144
182 MORPHOGENESIS OF EMBRYONIC EPITHELIUM 4 134 8.586e-05 0.002195
183 NEGATIVE REGULATION OF INTRACELLULAR SIGNAL TRANSDUCTION 6 437 9.971e-05 0.002535
184 POSITIVE REGULATION OF DEVELOPMENTAL PROCESS 9 1142 0.0001144 0.002894
185 EPIDERMAL GROWTH FACTOR RECEPTOR SIGNALING PATHWAY 3 55 0.000121 0.003044
186 POSITIVE REGULATION OF CELL GROWTH 4 148 0.0001261 0.003155
187 LIPID METABOLIC PROCESS 9 1158 0.0001272 0.003166
188 REGULATION OF EPITHELIAL CELL PROLIFERATION 5 285 0.0001297 0.003211
189 REGULATION OF VESICLE MEDIATED TRANSPORT 6 462 0.0001352 0.003328
190 REGULATION OF DEVELOPMENTAL GROWTH 5 289 0.0001385 0.003391
191 LEUKOCYTE DIFFERENTIATION 5 292 0.0001453 0.00354
192 REGULATION OF PROTEIN SERINE THREONINE KINASE ACTIVITY 6 470 0.0001484 0.003579
193 ANGIOGENESIS 5 293 0.0001477 0.003579
194 POSITIVE REGULATION OF RESPONSE TO EXTERNAL STIMULUS 5 296 0.0001549 0.003714
195 POSITIVE REGULATION OF SMOOTH MUSCLE CELL PROLIFERATION 3 60 0.0001569 0.003744
196 NEGATIVE REGULATION OF CELL COMMUNICATION 9 1192 0.0001586 0.003764
197 POSITIVE REGULATION OF STEM CELL PROLIFERATION 3 61 0.0001648 0.003893
198 REGULATION OF CELL DIFFERENTIATION 10 1492 0.0001687 0.003965
199 POSITIVE REGULATION OF BIOSYNTHETIC PROCESS 11 1805 0.0001699 0.003973
200 REGULATION OF CELL PROLIFERATION 10 1496 0.0001725 0.004013
201 REGULATION OF CELL ACTIVATION 6 484 0.0001741 0.00403
202 POSITIVE REGULATION OF PEPTIDYL TYROSINE PHOSPHORYLATION 4 162 0.0001786 0.004113
203 REGULATION OF HOMOTYPIC CELL CELL ADHESION 5 307 0.0001835 0.004207
204 REGULATION OF PROTEIN LOCALIZATION 8 950 0.0001883 0.004296
205 FATTY ACID HOMEOSTASIS 2 12 0.0001942 0.004402
206 HEMOSTASIS 5 311 0.0001949 0.004402
207 REGULATION OF EPITHELIAL CELL MIGRATION 4 166 0.0001961 0.004407
208 RESPONSE TO CARBOHYDRATE 4 168 0.0002053 0.004592
209 VESICLE MEDIATED TRANSPORT 9 1239 0.0002123 0.004727
210 AMIDE BIOSYNTHETIC PROCESS 6 507 0.0002238 0.004953
211 REGULATION OF CELL SIZE 4 172 0.0002246 0.004953
212 POSITIVE REGULATION OF ENDOTHELIAL CELL PROLIFERATION 3 68 0.0002276 0.004995
213 INDUCTION OF POSITIVE CHEMOTAXIS 2 13 0.0002293 0.005008
214 CELLULAR RESPONSE TO ELECTRICAL STIMULUS 2 14 0.0002672 0.005809
215 POSITIVE REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 8 1004 0.0002746 0.005943
216 REGULATION OF NEURAL PRECURSOR CELL PROLIFERATION 3 73 0.0002808 0.006048
217 REGULATION OF CELLULAR COMPONENT SIZE 5 337 0.0002826 0.006059
218 CELLULAR RESPONSE TO CARBOHYDRATE STIMULUS 3 74 0.0002923 0.006238
219 PHAGOCYTOSIS 4 190 0.0003282 0.006972
220 REGULATION OF HYDROLASE ACTIVITY 9 1327 0.0003543 0.007297
221 MAMMARY GLAND EPITHELIAL CELL DIFFERENTIATION 2 16 0.0003516 0.007297
222 ERBB SIGNALING PATHWAY 3 79 0.0003544 0.007297
223 TUBE DEVELOPMENT 6 552 0.0003532 0.007297
224 POSITIVE REGULATION OF VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR SIGNALING PATHWAY 2 16 0.0003516 0.007297
225 REGULATION OF CELLULAR PROTEIN LOCALIZATION 6 552 0.0003532 0.007297
226 DEVELOPMENTAL MATURATION 4 193 0.0003483 0.007297
227 NUCLEAR TRANSPORT 5 355 0.0003589 0.007356
228 HOMEOSTATIC PROCESS 9 1337 0.0003746 0.007644
229 REGULATION OF ENERGY HOMEOSTASIS 2 17 0.000398 0.007948
230 POSITIVE REGULATION OF GLYCOGEN METABOLIC PROCESS 2 17 0.000398 0.007948
231 MAMMARY GLAND ALVEOLUS DEVELOPMENT 2 17 0.000398 0.007948
232 MAMMARY GLAND LOBULE DEVELOPMENT 2 17 0.000398 0.007948
233 RESPONSE TO ALCOHOL 5 362 0.0003925 0.007948
234 BLOOD VESSEL MORPHOGENESIS 5 364 0.0004025 0.008003
235 CIRCULATORY SYSTEM PROCESS 5 366 0.0004127 0.008171
236 PEPTIDE METABOLIC PROCESS 6 571 0.0004229 0.008327
237 REGULATION OF MULTICELLULAR ORGANISMAL DEVELOPMENT 10 1672 0.0004259 0.008327
238 NEGATIVE REGULATION OF RESPONSE TO STIMULUS 9 1360 0.0004248 0.008327
239 ESTABLISHMENT OF LOCALIZATION IN CELL 10 1676 0.0004341 0.008417
240 POSITIVE REGULATION OF INTRACELLULAR TRANSPORT 5 370 0.0004337 0.008417
241 POSITIVE REGULATION OF CELL PROLIFERATION 7 814 0.0004469 0.008564
242 CELLULAR RESPONSE TO PROSTAGLANDIN E STIMULUS 2 18 0.0004473 0.008564
243 RESPONSE TO CAFFEINE 2 18 0.0004473 0.008564
244 POSITIVE REGULATION OF MAP KINASE ACTIVITY 4 207 0.0004539 0.008655
245 IMMUNE SYSTEM DEVELOPMENT 6 582 0.0004679 0.008887
246 LYMPHOCYTE DIFFERENTIATION 4 209 0.0004707 0.008902
247 POSITIVE REGULATION OF CELL DIFFERENTIATION 7 823 0.0004774 0.008994
248 REGULATION OF STEM CELL PROLIFERATION 3 88 0.0004866 0.009092
249 POSITIVE REGULATION OF PEPTIDYL SERINE PHOSPHORYLATION 3 88 0.0004866 0.009092
250 REGULATION OF CELL CELL ADHESION 5 380 0.0004897 0.009115
251 REGULATION OF TRANSLATION IN RESPONSE TO STRESS 2 19 0.0004993 0.009256
252 REGULATION OF PEPTIDYL TYROSINE PHOSPHORYLATION 4 213 0.0005055 0.009297
253 REGULATION OF CYSTEINE TYPE ENDOPEPTIDASE ACTIVITY 4 213 0.0005055 0.009297
254 SINGLE ORGANISM BEHAVIOR 5 384 0.0005136 0.009409
255 REGULATION OF CELL DEVELOPMENT 7 836 0.0005244 0.009569
NumGOOverlapSizeP ValueAdj. P Value
1 KINASE ACTIVITY 20 842 4.388e-19 4.077e-16
2 TRANSFERASE ACTIVITY TRANSFERRING PHOSPHORUS CONTAINING GROUPS 20 992 1.078e-17 5.009e-15
3 PROTEIN SERINE THREONINE KINASE ACTIVITY 13 445 2.605e-13 8.065e-11
4 PROTEIN KINASE ACTIVITY 14 640 1.279e-12 2.972e-10
5 PHOSPHATIDYLINOSITOL 3 KINASE ACTIVITY 7 70 2.941e-11 5.464e-09
6 X1 PHOSPHATIDYLINOSITOL 3 KINASE ACTIVITY 6 43 1.064e-10 1.647e-08
7 KINASE BINDING 12 606 2.372e-10 3.148e-08
8 PHOSPHATIDYLINOSITOL KINASE ACTIVITY 6 51 3.112e-10 3.614e-08
9 ENZYME BINDING 17 1737 8.382e-10 8.652e-08
10 ENZYME REGULATOR ACTIVITY 13 959 3.607e-09 3.351e-07
11 ADENYL NUCLEOTIDE BINDING 15 1514 1.093e-08 9.227e-07
12 RIBONUCLEOTIDE BINDING 16 1860 2.144e-08 1.66e-06
13 MOLECULAR FUNCTION REGULATOR 14 1353 2.369e-08 1.693e-06
14 KINASE REGULATOR ACTIVITY 7 186 2.9e-08 1.924e-06
15 PROTEIN SERINE THREONINE TYROSINE KINASE ACTIVITY 4 39 6.187e-07 3.832e-05
16 INSULIN RECEPTOR SUBSTRATE BINDING 3 11 8.023e-07 4.658e-05
17 PHOSPHATIDYLINOSITOL PHOSPHATE KINASE ACTIVITY 3 16 2.707e-06 0.0001479
18 PHOSPHATASE BINDING 5 162 8.742e-06 0.0004512
19 ENZYME ACTIVATOR ACTIVITY 7 471 1.459e-05 0.0007135
20 INSULIN RECEPTOR BINDING 3 32 2.352e-05 0.001092
21 PROTEIN PHOSPHATASE BINDING 4 120 5.589e-05 0.002472
22 TRANSLATION INITIATION FACTOR ACTIVITY 3 51 9.652e-05 0.004076
23 KINASE ACTIVATOR ACTIVITY 3 62 0.000173 0.006987
24 RNA CAP BINDING 2 13 0.0002293 0.008875
NumGOOverlapSizeP ValueAdj. P Value
1 PHOSPHATIDYLINOSITOL 3 KINASE COMPLEX 7 20 2.022e-15 1.181e-12
2 TRANSFERASE COMPLEX TRANSFERRING PHOSPHORUS CONTAINING GROUPS 10 237 6.394e-12 1.867e-09
3 TRANSFERASE COMPLEX 10 703 2.236e-07 3.371e-05
4 EXTRINSIC COMPONENT OF MEMBRANE 7 252 2.309e-07 3.371e-05
5 CATALYTIC COMPLEX 10 1038 7.59e-06 0.0008865

Over-represented Pathway

NumPathwayPathviewOverlapSizeP ValueAdj. P Value
1 hsa04150_mTOR_signaling_pathway 35 52 6.799e-98 1.224e-95
2 hsa04151_PI3K_AKT_signaling_pathway 26 351 5.409e-39 4.868e-37
3 hsa04910_Insulin_signaling_pathway 21 138 1.801e-37 1.081e-35
4 hsa04914_Progesterone.mediated_oocyte_maturation 13 87 1.069e-22 4.809e-21
5 hsa04012_ErbB_signaling_pathway 12 87 1.603e-20 5.772e-19
6 hsa04722_Neurotrophin_signaling_pathway 12 127 1.862e-18 5.587e-17
7 hsa04666_Fc_gamma_R.mediated_phagocytosis 11 95 5.804e-18 1.492e-16
8 hsa04510_Focal_adhesion 13 200 8.213e-18 1.848e-16
9 hsa04960_Aldosterone.regulated_sodium_reabsorption 9 42 2.151e-17 4.301e-16
10 hsa04973_Carbohydrate_digestion_and_absorption 9 44 3.411e-17 6.14e-16
11 hsa04370_VEGF_signaling_pathway 10 76 5.773e-17 9.447e-16
12 hsa04662_B_cell_receptor_signaling_pathway 9 75 5.828e-15 8.741e-14
13 hsa04664_Fc_epsilon_RI_signaling_pathway 9 79 9.505e-15 1.316e-13
14 hsa04210_Apoptosis 9 89 2.901e-14 3.73e-13
15 hsa04620_Toll.like_receptor_signaling_pathway 9 102 1.03e-13 1.236e-12
16 hsa04014_Ras_signaling_pathway 11 236 1.59e-13 1.789e-12
17 hsa04660_T_cell_receptor_signaling_pathway 9 108 1.746e-13 1.849e-12
18 hsa04380_Osteoclast_differentiation 9 128 8.311e-13 8.311e-12
19 hsa04630_Jak.STAT_signaling_pathway 9 155 4.744e-12 4.494e-11
20 hsa04062_Chemokine_signaling_pathway 9 189 2.836e-11 2.552e-10
21 hsa04070_Phosphatidylinositol_signaling_system 7 78 6.418e-11 5.501e-10
22 hsa04670_Leukocyte_transendothelial_migration 7 117 1.148e-09 9.397e-09
23 hsa04650_Natural_killer_cell_mediated_cytotoxicity 7 136 3.302e-09 2.584e-08
24 hsa04810_Regulation_of_actin_cytoskeleton 7 214 7.59e-08 5.692e-07
25 hsa04920_Adipocytokine_signaling_pathway 4 68 5.91e-06 4.255e-05
26 hsa04140_Regulation_of_autophagy 3 34 2.831e-05 0.000196
27 hsa04114_Oocyte_meiosis 4 114 4.574e-05 0.0003049
28 hsa04010_MAPK_signaling_pathway 5 268 9.724e-05 0.0006251
29 hsa00562_Inositol_phosphate_metabolism 3 57 0.0001346 0.0008357
30 hsa03013_RNA_transport 4 152 0.0001398 0.0008386
31 hsa04720_Long.term_potentiation 3 70 0.000248 0.00144
32 hsa04115_p53_signaling_pathway 2 69 0.006485 0.03648
33 hsa04350_TGF.beta_signaling_pathway 2 85 0.009698 0.0529
34 hsa04530_Tight_junction 2 133 0.02263 0.1198

lncRNA-mediated sponge

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Num lncRNA miRNAs           miRNAs count     Gene Sponge regulatory network lncRNA log2FC lncRNA pvalue Gene log2FC Gene pvalue lncRNA-gene Pearson correlation
1

HCG11

 hsa-miR-106b-5p;hsa-miR-107;hsa-miR-15a-5p;hsa-miR-17-3p;hsa-miR-17-5p;hsa-miR-20a-5p;hsa-miR-33a-3p;hsa-miR-362-3p;hsa-miR-502-3p;hsa-miR-93-5p 10 AKT3 Sponge network -0.781 0 -0.659 0.00047 0.574
2 DHRS4-AS1 hsa-miR-106b-5p;hsa-miR-1301-3p;hsa-miR-132-3p;hsa-miR-17-5p;hsa-miR-20a-5p;hsa-miR-21-5p;hsa-miR-221-3p;hsa-miR-222-3p;hsa-miR-582-5p;hsa-miR-589-3p 10 PIK3R1 Sponge network -0.646 0.01829 -0.892 0 0.557
3 LINC00261 hsa-miR-106b-5p;hsa-miR-1301-3p;hsa-miR-132-3p;hsa-miR-188-5p;hsa-miR-21-5p;hsa-miR-212-3p;hsa-miR-221-3p;hsa-miR-222-3p;hsa-miR-324-3p;hsa-miR-330-3p;hsa-miR-629-3p 11 PIK3R1 Sponge network -1.194 0 -0.892 0 0.513
4 RP11-12A2.3 hsa-miR-103a-3p;hsa-miR-106b-5p;hsa-miR-1301-3p;hsa-miR-132-3p;hsa-miR-17-5p;hsa-miR-188-5p;hsa-miR-200c-3p;hsa-miR-20a-5p;hsa-miR-21-5p;hsa-miR-221-3p;hsa-miR-222-3p;hsa-miR-93-5p 12 PIK3R1 Sponge network -4.779 0 -0.892 0 0.489
5 LINC01018 hsa-miR-103a-3p;hsa-miR-106b-5p;hsa-miR-1301-3p;hsa-miR-132-3p;hsa-miR-17-5p;hsa-miR-200c-3p;hsa-miR-21-5p;hsa-miR-212-3p;hsa-miR-221-3p;hsa-miR-222-3p;hsa-miR-324-3p;hsa-miR-338-5p;hsa-miR-589-3p;hsa-miR-629-3p;hsa-miR-93-5p 15 PIK3R1 Sponge network -3.231 0 -0.892 0 0.472
6 LDLRAD4-AS1 hsa-miR-103a-3p;hsa-miR-106b-5p;hsa-miR-1301-3p;hsa-miR-132-3p;hsa-miR-17-5p;hsa-miR-20a-5p;hsa-miR-21-5p;hsa-miR-221-3p;hsa-miR-222-3p;hsa-miR-93-5p 10 PIK3R1 Sponge network -3.366 0 -0.892 0 0.45
7 RP11-119D9.1 hsa-miR-106b-5p;hsa-miR-1301-3p;hsa-miR-132-3p;hsa-miR-188-5p;hsa-miR-200c-3p;hsa-miR-21-5p;hsa-miR-212-3p;hsa-miR-221-3p;hsa-miR-222-3p;hsa-miR-629-3p;hsa-miR-93-5p 11 PIK3R1 Sponge network -2.765 0 -0.892 0 0.418
8 RP11-290F5.1 hsa-miR-103a-3p;hsa-miR-106b-5p;hsa-miR-1301-3p;hsa-miR-132-3p;hsa-miR-17-5p;hsa-miR-20a-5p;hsa-miR-21-5p;hsa-miR-212-3p;hsa-miR-221-3p;hsa-miR-222-3p;hsa-miR-324-3p 11 PIK3R1 Sponge network -1.679 5.0E-5 -0.892 0 0.402
9 LINC00238 hsa-miR-106b-5p;hsa-miR-1301-3p;hsa-miR-132-3p;hsa-miR-17-5p;hsa-miR-185-5p;hsa-miR-188-5p;hsa-miR-200c-3p;hsa-miR-20a-5p;hsa-miR-212-3p;hsa-miR-221-3p;hsa-miR-222-3p;hsa-miR-629-3p 12 PIK3R1 Sponge network -4.997 0 -0.892 0 0.369
10 AC004862.6 hsa-miR-106b-5p;hsa-miR-1301-3p;hsa-miR-132-3p;hsa-miR-17-5p;hsa-miR-188-5p;hsa-miR-20a-5p;hsa-miR-21-5p;hsa-miR-212-3p;hsa-miR-221-3p;hsa-miR-222-3p;hsa-miR-629-3p;hsa-miR-93-5p 12 PIK3R1 Sponge network -2.202 0.00081 -0.892 0 0.357
11 PART1 hsa-let-7b-3p;hsa-let-7b-5p;hsa-let-7c-5p;hsa-miR-125b-5p;hsa-miR-130a-3p;hsa-miR-139-5p;hsa-miR-144-3p;hsa-miR-195-3p;hsa-miR-26a-5p;hsa-miR-30e-3p 10 PRKAA2 Sponge network 3.525 1.0E-5 0.91 0.01333 0.351
12 RP11-407B7.1 hsa-miR-1301-3p;hsa-miR-132-3p;hsa-miR-21-5p;hsa-miR-212-3p;hsa-miR-221-3p;hsa-miR-222-3p;hsa-miR-324-3p;hsa-miR-338-5p;hsa-miR-629-3p;hsa-miR-93-5p 10 PIK3R1 Sponge network -0.818 0.00584 -0.892 0 0.324
13 RP11-166D19.1 hsa-miR-106b-5p;hsa-miR-1301-3p;hsa-miR-17-5p;hsa-miR-185-5p;hsa-miR-188-5p;hsa-miR-20a-5p;hsa-miR-21-5p;hsa-miR-324-3p;hsa-miR-589-3p;hsa-miR-590-5p;hsa-miR-629-3p 11 PIK3R1 Sponge network -0.244 0.28835 -0.892 0 0.32
14 DLGAP1-AS2 hsa-let-7b-3p;hsa-let-7b-5p;hsa-let-7c-5p;hsa-miR-125b-5p;hsa-miR-130a-3p;hsa-miR-139-5p;hsa-miR-144-3p;hsa-miR-195-3p;hsa-miR-26a-5p;hsa-miR-30e-3p 10 PRKAA2 Sponge network 1.357 0 0.91 0.01333 0.306
15 GAS5 hsa-let-7b-3p;hsa-let-7b-5p;hsa-let-7c-5p;hsa-miR-125b-5p;hsa-miR-130a-3p;hsa-miR-139-5p;hsa-miR-144-3p;hsa-miR-195-3p;hsa-miR-22-5p;hsa-miR-26a-5p;hsa-miR-30e-3p 11 PRKAA2 Sponge network 1.966 0 0.91 0.01333 0.294
16 AC005562.1 hsa-let-7b-3p;hsa-let-7c-5p;hsa-miR-125b-5p;hsa-miR-130a-3p;hsa-miR-139-5p;hsa-miR-144-3p;hsa-miR-195-3p;hsa-miR-22-5p;hsa-miR-26a-5p;hsa-miR-30e-3p;hsa-miR-628-3p 11 PRKAA2 Sponge network 1.127 0 0.91 0.01333 0.29
17 AC016747.3 hsa-let-7b-3p;hsa-let-7b-5p;hsa-let-7c-5p;hsa-miR-125b-5p;hsa-miR-130a-3p;hsa-miR-139-5p;hsa-miR-144-3p;hsa-miR-195-3p;hsa-miR-22-5p;hsa-miR-26a-5p 10 PRKAA2 Sponge network 1.235 0 0.91 0.01333 0.29
18 RP4-717I23.3 hsa-let-7b-3p;hsa-let-7b-5p;hsa-let-7c-5p;hsa-miR-125b-5p;hsa-miR-130a-3p;hsa-miR-139-5p;hsa-miR-144-3p;hsa-miR-195-3p;hsa-miR-22-5p;hsa-miR-26a-5p;hsa-miR-30e-3p;hsa-miR-628-3p 12 PRKAA2 Sponge network 1.867 0 0.91 0.01333 0.285
19 RP1-228H13.5 hsa-let-7b-3p;hsa-let-7b-5p;hsa-let-7c-5p;hsa-miR-125b-5p;hsa-miR-130a-3p;hsa-miR-139-5p;hsa-miR-144-3p;hsa-miR-195-3p;hsa-miR-22-5p;hsa-miR-26a-5p;hsa-miR-30e-3p 11 PRKAA2 Sponge network 1.554 0 0.91 0.01333 0.285
20 AP001469.9 hsa-let-7b-3p;hsa-let-7b-5p;hsa-let-7c-5p;hsa-miR-125b-5p;hsa-miR-130a-3p;hsa-miR-139-5p;hsa-miR-195-3p;hsa-miR-22-5p;hsa-miR-26a-5p;hsa-miR-30e-3p 10 PRKAA2 Sponge network 2.428 0 0.91 0.01333 0.279
21 AC074117.10 hsa-let-7b-3p;hsa-let-7b-5p;hsa-let-7c-5p;hsa-miR-125b-5p;hsa-miR-130a-3p;hsa-miR-139-5p;hsa-miR-144-3p;hsa-miR-195-3p;hsa-miR-22-5p;hsa-miR-26a-5p;hsa-miR-30e-3p 11 PRKAA2 Sponge network 1.254 0 0.91 0.01333 0.275
22 RP11-121C2.2 hsa-let-7b-3p;hsa-let-7b-5p;hsa-let-7c-5p;hsa-miR-125b-5p;hsa-miR-130a-3p;hsa-miR-139-5p;hsa-miR-144-3p;hsa-miR-195-3p;hsa-miR-22-5p;hsa-miR-26a-5p;hsa-miR-30e-3p 11 PRKAA2 Sponge network 1.286 0 0.91 0.01333 0.273
23 RP11-7F17.3 hsa-miR-103a-3p;hsa-miR-106b-5p;hsa-miR-1301-3p;hsa-miR-132-3p;hsa-miR-17-5p;hsa-miR-188-5p;hsa-miR-20a-5p;hsa-miR-21-5p;hsa-miR-221-3p;hsa-miR-222-3p;hsa-miR-324-3p 11 PIK3R1 Sponge network -0.873 0.00204 -0.892 0 0.271
24 SMIM2-AS1 hsa-miR-103a-3p;hsa-miR-106b-5p;hsa-miR-1301-3p;hsa-miR-132-3p;hsa-miR-17-5p;hsa-miR-200c-3p;hsa-miR-20a-5p;hsa-miR-21-5p;hsa-miR-212-3p;hsa-miR-221-3p;hsa-miR-222-3p;hsa-miR-629-3p 12 PIK3R1 Sponge network -0.66 0.00587 -0.892 0 0.27
25 TMCC1-AS1 hsa-let-7b-3p;hsa-let-7b-5p;hsa-let-7c-5p;hsa-miR-125b-5p;hsa-miR-130a-3p;hsa-miR-139-5p;hsa-miR-144-3p;hsa-miR-195-3p;hsa-miR-22-5p;hsa-miR-26a-5p 10 PRKAA2 Sponge network 2.298 0 0.91 0.01333 0.258
26 KB-1460A1.5 hsa-let-7b-3p;hsa-let-7b-5p;hsa-let-7c-5p;hsa-miR-125b-5p;hsa-miR-130a-3p;hsa-miR-139-5p;hsa-miR-144-3p;hsa-miR-195-3p;hsa-miR-22-5p;hsa-miR-26a-5p;hsa-miR-30e-3p 11 PRKAA2 Sponge network 1.949 0 0.91 0.01333 0.253
27 LINC00680 hsa-let-7b-3p;hsa-let-7b-5p;hsa-let-7c-5p;hsa-miR-125b-5p;hsa-miR-130a-3p;hsa-miR-139-5p;hsa-miR-144-3p;hsa-miR-195-3p;hsa-miR-22-5p;hsa-miR-26a-5p 10 PRKAA2 Sponge network 1.404 0 0.91 0.01333 0.252
28 AC073283.4 hsa-let-7b-3p;hsa-let-7b-5p;hsa-let-7c-5p;hsa-miR-125b-5p;hsa-miR-139-5p;hsa-miR-144-3p;hsa-miR-195-3p;hsa-miR-22-5p;hsa-miR-26a-5p;hsa-miR-30e-3p 10 PRKAA2 Sponge network 1.514 0 0.91 0.01333 0.251

Quest ID: 52ab0b8ba0b6fc9d7150c6936c016bde