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This regulatory network was inferred from the input dataset. The miRNAs and mRNAs are presented as round and rectangle nodes respectively. The numerical value popped up upon mouse over the gene node is the log2 transformed fold-change of the gene expression between the two groups. All of the nodes are clickable, and the detailed information of the miRNAs/mRNAs and related cancer pathway will be displayed in another window. The edges between nodes are supported by both interactions (predicted or experimentally verified) and correlations learnt from cancer dataset. The numerical value popped up upon mouse over the edge is the correlation beat value (effect size) between the two nodes. The experimental evidences of the edges reported in previous cancer studies are highlighted by red/orange color. All of these information can be accessed by the "mouse-over" action. This network shows a full map of the miRNA-mRNA regulation of the input gene list(s), and the hub miRNAs (with the high network degree/betweenness centrality) would be the potential cancer drivers or tumor suppressors. The full result table can be accessed in the "Regulations" tab.

"miRNACancerMAP" is also a network visualization tool for users to draw their regulatory network by personal customization. Users can set the complexity of the network by limiting the number of nodes or edges. And the color of the nodes can be defined by different categories of the mRNAs and miRNAs, such as Gene-Ontology, pathway, and expression status. Users can also select to use network degree or network betweenness centrality to define the node size. And edges can be black or colored by the correlation. Purple edge means negative correlation (mostly found between miRNA and mRNA), and blue edge means positive correlation (found in PPI or miRNA-miRNA sponge effect). We can also add the protein-protein interactions (PPI) into the network. This result will show the cluster of genes regulated by some specific miRNAs. Additionally, miRNA-miRNA edges can be added by the "miRNA sponge" button, presenting some clusters of miRNAs that have the interactions via sponge effect.

miRNA-gene regulations

(Download full result)

Num microRNA           Gene miRNA log2FC miRNA pvalue Gene log2FC Gene pvalue Interaction Correlation beta Correlation P-value PMID Reported in cancer studies
1 hsa-miR-140-3p ADAM17 -0.3 0.12754 0.99 6.0E-5 PITA; miRNATAP -0.47 0 NA
2 hsa-miR-326 ADAM17 -0.43 0.26299 0.99 6.0E-5 miRanda -0.26 0 26111641 Adam17 a Target of Mir 326 Promotes Emt Induced Cells Invasion in Lung Adenocarcinoma; RT-PCR and Western blot were used to detect the expression of miR-326 and ADAM17 in lung adenocarcinoma samples n=73; Furthermore we confirmed that ADAM17 is a target of miR-326 which is involved in EMT and cells invasion; These findings revealed that ADAM17 a target of miR-326 promoted EMT-induced cells invasion in lung adenocarcinoma
3 hsa-miR-338-3p ADAM17 -0.96 0.01915 0.99 6.0E-5 PITA; miRanda; miRNATAP -0.31 0 26617808 MiR 338 3p inhibits the proliferation and migration of gastric cancer cells by targeting ADAM17; Moreover we identified A disintegrin and metalloproteinase 17 ADAM17 gene as potential target of miR-338-3p; Importantly ADAM17 rescued the miR-338-3p mediated inhibition of cell proliferation migration and invasion; Our study suggested that miR-338-3p is significantly decreased in gastric cancer and inhibits cell proliferation migration and invasion partially via the downregulation of ADAM17
4 hsa-miR-7-1-3p ADAM17 0.71 0.04123 0.99 6.0E-5 mirMAP -0.23 0 NA
5 hsa-miR-186-5p CREBBP 0.15 0.43471 -0.11 0.45436 mirMAP; miRNATAP -0.14 0.00768 NA
6 hsa-miR-342-3p CTBP2 0.32 0.26915 -0.01 0.94438 MirTarget; PITA; miRanda; miRNATAP -0.29 0 NA
7 hsa-miR-107 DLL1 0.9 5.0E-5 0.23 0.51166 PITA; miRanda; miRNATAP -0.3 0.00774 NA
8 hsa-miR-326 DLL1 -0.43 0.26299 0.23 0.51166 miRanda -0.21 0.00151 NA
9 hsa-miR-338-5p DLL1 -1.2 0.01003 0.23 0.51166 PITA; miRNATAP -0.22 2.0E-5 NA
10 hsa-miR-429 DLL1 1.4 0.009 0.23 0.51166 miRanda; miRNATAP -0.12 0.00861 NA
11 hsa-let-7a-3p DLL4 0.5 0.04111 0.32 0.35188 miRNATAP -0.33 0.001 NA
12 hsa-let-7b-3p DLL4 0.22 0.29604 0.32 0.35188 miRNATAP -0.33 0.00644 NA
13 hsa-miR-125b-5p DLL4 -0.51 0.13327 0.32 0.35188 miRNATAP -0.29 4.0E-5 NA
14 hsa-miR-199a-3p DLL4 0.85 0.00036 0.32 0.35188 PITA -0.31 0.00277 NA
15 hsa-miR-199b-3p DLL4 0.86 0.00032 0.32 0.35188 PITA -0.31 0.00275 NA
16 hsa-miR-27a-3p DLL4 1.3 0 0.32 0.35188 miRNATAP -0.5 0 NA
17 hsa-miR-27b-3p DLL4 0.08 0.72527 0.32 0.35188 miRNATAP -0.57 0 NA
18 hsa-miR-944 DLL4 3.33 0.01778 0.32 0.35188 PITA; miRNATAP -0.15 0 NA
19 hsa-miR-1254 DTX1 0.94 0.06055 -0.03 0.93372 miRNATAP -0.3 0 NA
20 hsa-miR-324-5p DTX1 1.09 3.0E-5 -0.03 0.93372 PITA; miRanda -0.45 1.0E-5 NA
21 hsa-miR-331-3p DTX1 1.05 0.0001 -0.03 0.93372 PITA; miRNATAP -0.41 3.0E-5 NA
22 hsa-miR-421 DTX1 1.81 0 -0.03 0.93372 PITA; miRanda; miRNATAP -0.25 0.00092 NA
23 hsa-miR-429 DTX1 1.4 0.009 -0.03 0.93372 miRNATAP -0.18 0.00019 NA
24 hsa-miR-484 DTX1 0.71 0.00234 -0.03 0.93372 miRNATAP -0.37 0.00134 NA
25 hsa-let-7e-5p DTX2 0.41 0.19626 1.01 5.0E-5 miRNATAP -0.16 0.00444 NA
26 hsa-miR-107 DTX3 0.9 5.0E-5 -0.4 0.34209 miRanda -0.43 0.00139 NA
27 hsa-miR-148a-5p DTX3 -0.69 0.0793 -0.4 0.34209 mirMAP -0.24 0.00121 NA
28 hsa-miR-3614-5p DTX3 1.1 0.00706 -0.4 0.34209 MirTarget -0.38 0 NA
29 hsa-let-7b-5p DTX4 0.06 0.7814 0.44 0.32524 miRNATAP -0.67 1.0E-5 NA
30 hsa-miR-125b-5p DTX4 -0.51 0.13327 0.44 0.32524 mirMAP; miRNATAP -0.38 4.0E-5 NA
31 hsa-miR-136-5p DTX4 -0.39 0.19926 0.44 0.32524 mirMAP -0.3 0.00381 NA
32 hsa-miR-27a-3p DTX4 1.3 0 0.44 0.32524 miRNATAP -0.77 0 NA
33 hsa-miR-27b-3p DTX4 0.08 0.72527 0.44 0.32524 miRNATAP -0.76 0 NA
34 hsa-miR-365a-3p DTX4 -0.89 0.00255 0.44 0.32524 mirMAP -0.73 0 NA
35 hsa-miR-150-5p DVL3 0.15 0.75372 0.51 0.01916 MirTarget -0.14 3.0E-5 NA
36 hsa-miR-29b-2-5p DVL3 -1.7 0 0.51 0.01916 MirTarget -0.26 0 NA
37 hsa-miR-30d-3p DVL3 -0.55 0.04337 0.51 0.01916 MirTarget -0.21 0.00028 NA
38 hsa-miR-338-3p DVL3 -0.96 0.01915 0.51 0.01916 miRanda -0.23 0 NA
39 hsa-miR-362-5p DVL3 -0.35 0.35491 0.51 0.01916 PITA; TargetScan; miRNATAP -0.21 0 NA
40 hsa-miR-106b-5p EP300 1.71 0 0.03 0.83304 miRNATAP -0.1 0.00164 NA
41 hsa-miR-212-3p EP300 0.96 0.00133 0.03 0.83304 MirTarget; miRNATAP -0.12 0.00033 NA
42 hsa-miR-26a-5p EP300 -0.38 0.04425 0.03 0.83304 miRNATAP -0.19 0.00038 NA
43 hsa-miR-26b-5p EP300 -0.3 0.16008 0.03 0.83304 miRNAWalker2 validate; miRNATAP -0.14 0.00299 NA
44 hsa-miR-342-3p HDAC1 0.32 0.26915 0.78 0 miRanda -0.13 0.00172 NA
45 hsa-miR-145-5p HDAC2 -1.75 2.0E-5 0.54 0.00083 miRNAWalker2 validate -0.12 1.0E-5 23499894 MiR 145 functions as a tumor suppressor by directly targeting histone deacetylase 2 in liver cancer; Ectopic expression of miRNA mimics evidenced that miR-145 suppresses HDAC2 expression in HCC cells; In conclusion we suggest that loss or suppression of miR-145 may cause aberrant overexpression of HDAC2 and promote HCC tumorigenesis
46 hsa-miR-195-3p HDAC2 -1.35 2.0E-5 0.54 0.00083 mirMAP -0.14 9.0E-5 NA
47 hsa-miR-30a-3p HDAC2 -1.73 0 0.54 0.00083 mirMAP -0.11 0.00143 NA
48 hsa-miR-30a-5p HDAC2 -1.72 0 0.54 0.00083 mirMAP -0.11 0.00069 NA
49 hsa-miR-129-5p JAG1 -2.57 0 0.96 0.00974 PITA; miRanda; miRNATAP -0.15 0.00169 NA
50 hsa-miR-140-3p JAG1 -0.3 0.12754 0.96 0.00974 MirTarget; PITA; miRNATAP -0.5 0.00033 NA
51 hsa-miR-186-5p JAG1 0.15 0.43471 0.96 0.00974 MirTarget; miRNATAP -0.62 1.0E-5 NA
52 hsa-miR-200a-3p JAG1 0.72 0.19391 0.96 0.00974 miRNATAP -0.14 0.0045 NA
53 hsa-miR-217 JAG1 -0.01 0.98082 0.96 0.00974 PITA; miRanda -0.16 0.00328 NA
54 hsa-miR-26a-5p JAG1 -0.38 0.04425 0.96 0.00974 MirTarget; miRNATAP -0.53 0.00017 NA
55 hsa-miR-26b-3p JAG1 -0.01 0.96577 0.96 0.00974 miRNATAP -0.3 0.00827 NA
56 hsa-miR-26b-5p JAG1 -0.3 0.16008 0.96 0.00974 MirTarget; miRNATAP -0.35 0.00639 NA
57 hsa-miR-335-3p JAG1 2.52 0 0.96 0.00974 MirTarget -0.16 0.00723 NA
58 hsa-miR-335-5p JAG1 1.6 6.0E-5 0.96 0.00974 miRNATAP -0.27 3.0E-5 NA
59 hsa-miR-361-3p JAG1 -0.13 0.56605 0.96 0.00974 miRNATAP -0.39 0.00176 NA
60 hsa-miR-375 JAG1 -2.95 0.0057 0.96 0.00974 miRNAWalker2 validate -0.16 0 NA
61 hsa-miR-429 JAG1 1.4 0.009 0.96 0.00974 miRanda -0.13 0.00811 NA
62 hsa-miR-628-5p JAG1 -0.54 0.03779 0.96 0.00974 MirTarget; PITA; miRNATAP -0.41 6.0E-5 NA
63 hsa-miR-98-5p JAG1 0.92 3.0E-5 0.96 0.00974 miRNAWalker2 validate -0.35 0.00367 NA
64 hsa-miR-140-3p JAG2 -0.3 0.12754 1.13 0.00219 miRNATAP -0.8 0 NA
65 hsa-miR-140-5p JAG2 0.21 0.303 1.13 0.00219 miRanda -0.52 9.0E-5 NA
66 hsa-miR-30a-5p JAG2 -1.72 0 1.13 0.00219 miRNATAP -0.29 0.00011 NA
67 hsa-miR-30b-5p JAG2 -0.43 0.05936 1.13 0.00219 miRNATAP -0.39 0.00074 NA
68 hsa-miR-30c-5p JAG2 -0.98 5.0E-5 1.13 0.00219 miRNATAP -0.38 0.00042 NA
69 hsa-miR-30d-5p JAG2 -0.55 0.01401 1.13 0.00219 miRNATAP -0.51 1.0E-5 NA
70 hsa-miR-335-5p JAG2 1.6 6.0E-5 1.13 0.00219 miRNAWalker2 validate -0.19 0.00353 NA
71 hsa-miR-501-3p JAG2 0.73 0.02704 1.13 0.00219 TargetScan; miRNATAP -0.25 0.00174 NA
72 hsa-miR-502-3p JAG2 -0.16 0.55747 1.13 0.00219 miRNATAP -0.54 0 NA
73 hsa-miR-342-3p KAT2A 0.32 0.26915 0.95 0 MirTarget; miRanda -0.12 0.0077 NA
74 hsa-miR-106b-5p KAT2B 1.71 0 -1.91 0 miRNAWalker2 validate; miRTarBase; MirTarget -0.4 0 NA
75 hsa-miR-17-5p KAT2B 1.66 0 -1.91 0 MirTarget; TargetScan -0.45 0 23095762 miR 17 5p targets the p300/CBP associated factor and modulates androgen receptor transcriptional activity in cultured prostate cancer cells; Targeting of PCAF by miR-17-5p was evaluated using the luciferase reporter assay; Expression of PCAF in PCa cells was associated with the downregulation of miR-17-5p; Targeting of the 3'-untranslated region of PCAF mRNA by miR-17-5p caused translational suppression and RNA degradation and consequently modulation of AR transcriptional activity in PCa cells; PCAF is upregulated in cultured PCa cells and upregulation of PCAF is associated with the downregulation of miR-17-5p; Targeting of PCAF by miR-17-5p modulates AR transcriptional activity and cell growth in cultured PCa cells
76 hsa-miR-181a-5p KAT2B 1.39 0 -1.91 0 miRNAWalker2 validate; miRTarBase; MirTarget -0.32 0.00139 NA
77 hsa-miR-181b-5p KAT2B 1.64 0 -1.91 0 miRNAWalker2 validate; miRTarBase; MirTarget -0.3 0.00011 NA
78 hsa-miR-181d-5p KAT2B 0.65 0.01434 -1.91 0 MirTarget -0.25 0.00538 NA
79 hsa-miR-19a-3p KAT2B 1.27 0.00011 -1.91 0 miRNAWalker2 validate -0.27 0.00015 NA
80 hsa-miR-19b-3p KAT2B 0.76 0.00653 -1.91 0 miRNAWalker2 validate -0.28 0.00111 NA
81 hsa-miR-20a-3p KAT2B 1.14 0.00045 -1.91 0 MirTarget -0.42 0 NA
82 hsa-miR-20a-5p KAT2B 1.45 0 -1.91 0 MirTarget -0.43 0 NA
83 hsa-miR-25-3p KAT2B 1.01 0.00042 -1.91 0 miRNAWalker2 validate; miRTarBase; MirTarget -0.3 0.00024 NA
84 hsa-miR-361-5p KAT2B 0.41 0.01813 -1.91 0 miRanda -0.41 0.00393 NA
85 hsa-miR-590-3p KAT2B 1.12 0.00016 -1.91 0 MirTarget; miRanda; mirMAP; miRNATAP -0.22 0.00595 NA
86 hsa-miR-590-5p KAT2B 1.04 0.00027 -1.91 0 miRanda -0.33 6.0E-5 NA
87 hsa-miR-92a-3p KAT2B 1.22 1.0E-5 -1.91 0 miRNAWalker2 validate; MirTarget -0.52 0 NA
88 hsa-miR-92b-3p KAT2B 1.34 0 -1.91 0 MirTarget -0.49 0 NA
89 hsa-miR-93-5p KAT2B 1.75 0 -1.91 0 miRNAWalker2 validate; miRTarBase; MirTarget -0.39 0 NA
90 hsa-miR-125a-5p LFNG -0.88 0.00021 -0.13 0.76587 MirTarget; PITA; miRanda; miRNATAP -0.37 0.00675 NA
91 hsa-miR-125b-5p LFNG -0.51 0.13327 -0.13 0.76587 MirTarget; miRNATAP -0.56 0 NA
92 hsa-miR-214-3p LFNG 1.01 0.00625 -0.13 0.76587 MirTarget -0.23 0.00884 NA
93 hsa-miR-365a-3p LFNG -0.89 0.00255 -0.13 0.76587 mirMAP -0.54 0 NA
94 hsa-miR-30b-5p MAML1 -0.43 0.05936 0.1 0.48957 MirTarget -0.13 0.00324 NA
95 hsa-miR-576-5p MAML2 0.63 0.04171 0.01 0.97433 mirMAP -0.2 0.00345 NA
96 hsa-miR-205-5p MFNG 3.14 0.02932 -0.44 0.22631 MirTarget -0.11 0 NA
97 hsa-miR-219a-5p MFNG 0.61 0.08545 -0.44 0.22631 MirTarget -0.32 1.0E-5 NA
98 hsa-miR-2355-5p MFNG 0.59 0.12059 -0.44 0.22631 MirTarget -0.22 0.00087 NA
99 hsa-miR-101-3p NOTCH1 -0.45 0.02834 1.03 0.00018 MirTarget -0.41 3.0E-5 NA
100 hsa-miR-139-5p NOTCH1 -1.83 0 1.03 0.00018 PITA; miRanda; miRNATAP -0.24 0.0001 27173050; 25149074; 26299922; 27738333; 24885920 miR 139 5p sensitizes colorectal cancer cells to 5 fluorouracil by targeting NOTCH 1;MiR 139 5p inhibits migration and invasion of colorectal cancer by downregulating AMFR and NOTCH1; Mechanistic investigations revealed that miR-139-5p suppress CRC cell invasion and metastasis by targeting AMFR and NOTCH1;MiR 139 5p inhibits the biological function of breast cancer cells by targeting Notch1 and mediates chemosensitivity to docetaxel; MiR-139-5p expression in MCF-7 MCF-7/Doc cells and in selected breast cancer tissue samples was confirmed by real-time PCR; cell viability was analyzed by Cell Counting Kit-8 assay; apoptosis and cell cycle were analyzed by flow cytometry; control of metastasis and invasion of breast cancer cells was measured by transwell assay; expression of Notch1 was measured by western blot; a luciferase reporter vector was constructed to identify the miR-139-5p target gene; MiR-139-5p not only attenuated the development of breast cancer cells but also mediated drug-resistance by regulating the expression of the downstream target gene Notch1;MiR 139 5p reverses CD44+/CD133+ associated multidrug resistance by downregulating NOTCH1 in colorectal carcinoma cells; We also identified NOTCH1 an important protein for stem cell maintenance and function as a direct target of miR-139-5p both in vitro and in a knockout mouse model; Notch1 expression was upregulated in tumor samples and inversely correlated with expression of miR-139-5p; Silencing NOTCH1 exerted an effect similar to overexpression of miR-139-5p by inhibiting the CD44+ and CD133+ population and reversing the drug-resistant phenotype; In conclusion miR-139-5p downregulated NOTCH1 signaling to reverse CD44+/CD133+-associated MDR in colorectal cancer cells;microRNA 139 5p exerts tumor suppressor function by targeting NOTCH1 in colorectal cancer
101 hsa-miR-30a-5p NOTCH1 -1.72 0 1.03 0.00018 miRNAWalker2 validate; miRTarBase; miRNATAP -0.24 3.0E-5 NA
102 hsa-miR-30b-5p NOTCH1 -0.43 0.05936 1.03 0.00018 miRNATAP -0.36 4.0E-5 NA
103 hsa-miR-30c-5p NOTCH1 -0.98 5.0E-5 1.03 0.00018 miRNATAP -0.33 6.0E-5 23974200 We identified NOTCH1 as a direct target of miR-30c; Finally a block of miR-30c prevents C/EBPα-induced downregulation of Notch1 protein and leads to a reduced CD11b expression in myeloid differentiation; Our study presents the first evidence that C/EBPα miR-30c and Notch1 together play a critical role in granulocytic differentiation and AML and particularly in AML with CEBPA mutations
104 hsa-miR-30d-5p NOTCH1 -0.55 0.01401 1.03 0.00018 miRNATAP -0.28 0.00181 NA
105 hsa-miR-32-5p NOTCH1 0.42 0.10646 1.03 0.00018 miRNATAP -0.25 0.00133 NA
106 hsa-miR-326 NOTCH1 -0.43 0.26299 1.03 0.00018 miRNAWalker2 validate; miRTarBase -0.17 0.00149 NA
107 hsa-miR-103a-3p NOTCH2 0.84 0 -0.26 0.28775 MirTarget -0.37 0.00028 NA
108 hsa-miR-106a-5p NOTCH2 -0.17 0.64287 -0.26 0.28775 miRNAWalker2 validate -0.13 0.00358 NA
109 hsa-miR-107 NOTCH2 0.9 5.0E-5 -0.26 0.28775 miRNAWalker2 validate; MirTarget; miRanda; miRNATAP -0.36 0 NA
110 hsa-miR-130b-5p NOTCH2 0.7 0.05101 -0.26 0.28775 miRNAWalker2 validate; MirTarget -0.18 0.00012 NA
111 hsa-miR-15a-5p NOTCH2 1.04 0 -0.26 0.28775 MirTarget -0.38 0 NA
112 hsa-miR-15b-5p NOTCH2 1.62 0 -0.26 0.28775 MirTarget -0.22 0.00025 NA
113 hsa-miR-16-1-3p NOTCH2 1.43 0 -0.26 0.28775 mirMAP -0.19 0.00335 NA
114 hsa-miR-16-5p NOTCH2 1.01 1.0E-5 -0.26 0.28775 miRNAWalker2 validate; MirTarget -0.39 0 NA
115 hsa-miR-17-5p NOTCH2 1.66 0 -0.26 0.28775 miRNAWalker2 validate -0.24 1.0E-5 NA
116 hsa-miR-183-5p NOTCH2 1.66 0.00052 -0.26 0.28775 miRNAWalker2 validate -0.12 0.00103 NA
117 hsa-miR-185-5p NOTCH2 1.14 0 -0.26 0.28775 MirTarget -0.28 0.00099 NA
118 hsa-miR-186-5p NOTCH2 0.15 0.43471 -0.26 0.28775 mirMAP -0.32 0.0006 NA
119 hsa-miR-18a-3p NOTCH2 2.35 0 -0.26 0.28775 MirTarget -0.16 4.0E-5 NA
120 hsa-miR-200a-5p NOTCH2 1.5 0.00264 -0.26 0.28775 mirMAP -0.13 9.0E-5 NA
121 hsa-miR-200b-5p NOTCH2 0.97 0.05305 -0.26 0.28775 mirMAP -0.16 1.0E-5 NA
122 hsa-miR-25-3p NOTCH2 1.01 0.00042 -0.26 0.28775 miRNAWalker2 validate -0.19 0.00136 NA
123 hsa-miR-29b-3p NOTCH2 -0.23 0.36746 -0.26 0.28775 MirTarget -0.19 0.00526 NA
124 hsa-miR-30b-5p NOTCH2 -0.43 0.05936 -0.26 0.28775 mirMAP -0.24 0.00141 NA
125 hsa-miR-34a-5p NOTCH2 0.79 0.00024 -0.26 0.28775 miRNAWalker2 validate; miRNATAP -0.22 0.00531 NA
126 hsa-miR-423-5p NOTCH2 0.83 0.00079 -0.26 0.28775 MirTarget -0.25 0.00035 NA
127 hsa-miR-424-5p NOTCH2 1.09 0.00042 -0.26 0.28775 MirTarget -0.22 7.0E-5 NA
128 hsa-miR-429 NOTCH2 1.4 0.009 -0.26 0.28775 miRNATAP -0.15 0 NA
129 hsa-miR-577 NOTCH2 0.91 0.22561 -0.26 0.28775 mirMAP -0.13 0 NA
130 hsa-miR-590-3p NOTCH2 1.12 0.00016 -0.26 0.28775 miRanda -0.2 0.00043 NA
131 hsa-miR-590-5p NOTCH2 1.04 0.00027 -0.26 0.28775 miRanda -0.21 0.00041 NA
132 hsa-miR-7-1-3p NOTCH2 0.71 0.04123 -0.26 0.28775 MirTarget; mirMAP -0.21 2.0E-5 NA
133 hsa-miR-92a-3p NOTCH2 1.22 1.0E-5 -0.26 0.28775 miRNAWalker2 validate -0.29 0 NA
134 hsa-miR-940 NOTCH2 1.64 0.00069 -0.26 0.28775 MirTarget -0.13 0.00177 NA
135 hsa-miR-150-5p NOTCH3 0.15 0.75372 1.32 0.00125 miRNAWalker2 validate; miRTarBase -0.16 0.00986 NA
136 hsa-miR-200a-3p NOTCH3 0.72 0.19391 1.32 0.00125 mirMAP -0.29 0 NA
137 hsa-miR-335-5p NOTCH3 1.6 6.0E-5 1.32 0.00125 miRNAWalker2 validate -0.27 0.00023 NA
138 hsa-miR-491-5p NOTCH3 -0.69 0.03136 1.32 0.00125 MirTarget; miRanda -0.3 0.00117 NA
139 hsa-miR-660-5p NOTCH3 -0.02 0.93887 1.32 0.00125 MirTarget -0.76 0 NA
140 hsa-miR-7-5p NOTCH3 1.64 0.01244 1.32 0.00125 MirTarget -0.29 0 NA
141 hsa-miR-324-5p NOTCH4 1.09 3.0E-5 -0.76 0.0205 miRanda -0.28 0.00164 NA
142 hsa-miR-34c-5p NOTCH4 2.21 0.00038 -0.76 0.0205 miRNAWalker2 validate; miRTarBase; miRanda; miRNATAP -0.17 0 22074923 Ectopic expression of miR-34c reduced the self-renewal of BT-ICs inhibited epithelial-mesenchymal transition and suppressed migration of the tumor cells via silencing target gene Notch4
143 hsa-miR-103a-3p NUMB 0.84 0 -0.06 0.68101 miRNAWalker2 validate -0.17 0.00578 NA
144 hsa-miR-374b-5p NUMB -0.19 0.3948 -0.06 0.68101 miRNATAP -0.15 0.00115 NA
145 hsa-let-7g-5p NUMBL 0.33 0.24114 0.2 0.4531 miRNATAP -0.29 1.0E-5 NA
146 hsa-miR-140-5p NUMBL 0.21 0.303 0.2 0.4531 MirTarget; miRanda; miRNATAP -0.41 1.0E-5 NA
147 hsa-miR-141-3p NUMBL 1.46 0.00116 0.2 0.4531 TargetScan -0.13 0.00179 NA
148 hsa-miR-142-3p NUMBL 1.32 0.00015 0.2 0.4531 miRNATAP -0.19 0.00022 NA
149 hsa-miR-194-3p NUMBL 0.26 0.82181 0.2 0.4531 MirTarget -0.13 0 NA
150 hsa-miR-338-3p NUMBL -0.96 0.01915 0.2 0.4531 miRanda -0.27 0 NA

Over-represented Gene Ontology Biological Process

NumGOOverlapSizeP ValueAdj. P Value
1 NOTCH SIGNALING PATHWAY 22 114 9.556e-44 4.446e-40
2 NOTCH RECEPTOR PROCESSING 9 16 1.626e-22 3.783e-19
3 REGULATION OF NOTCH SIGNALING PATHWAY 9 67 5.778e-16 8.962e-13
4 TRANSCRIPTION INITIATION FROM RNA POLYMERASE II PROMOTER 10 153 1.97e-14 2.292e-11
5 POSITIVE REGULATION OF NOTCH SIGNALING PATHWAY 7 34 5.42e-14 5.044e-11
6 EPITHELIUM DEVELOPMENT 16 945 8.4e-14 6.514e-11
7 POSITIVE REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 16 1004 2.135e-13 1.419e-10
8 POSITIVE REGULATION OF GENE EXPRESSION 19 1733 3.057e-13 1.684e-10
9 DNA TEMPLATED TRANSCRIPTION INITIATION 10 202 3.257e-13 1.684e-10
10 TISSUE DEVELOPMENT 18 1518 5.036e-13 2.343e-10
11 CELL FATE COMMITMENT 10 227 1.047e-12 4.431e-10
12 REGULATION OF NERVOUS SYSTEM DEVELOPMENT 14 750 1.416e-12 5.489e-10
13 ANATOMICAL STRUCTURE FORMATION INVOLVED IN MORPHOGENESIS 15 957 2.074e-12 7.423e-10
14 REGULATION OF CELL DIFFERENTIATION 17 1492 6.089e-12 2.024e-09
15 REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 18 1784 7.833e-12 2.43e-09
16 POSITIVE REGULATION OF BIOSYNTHETIC PROCESS 18 1805 9.543e-12 2.775e-09
17 MORPHOGENESIS OF AN EPITHELIUM 11 400 1.056e-11 2.891e-09
18 LEUKOCYTE DIFFERENTIATION 10 292 1.277e-11 3.3e-09
19 EMBRYO DEVELOPMENT 14 894 1.5e-11 3.672e-09
20 TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 13 724 1.862e-11 4.332e-09
21 LYMPHOCYTE DIFFERENTIATION 9 209 2.066e-11 4.577e-09
22 IMMUNE SYSTEM DEVELOPMENT 12 582 2.807e-11 5.679e-09
23 CELL SURFACE RECEPTOR SIGNALING PATHWAY INVOLVED IN HEART DEVELOPMENT 5 16 2.752e-11 5.679e-09
24 REGULATION OF MULTICELLULAR ORGANISMAL DEVELOPMENT 17 1672 3.751e-11 7.272e-09
25 HEART DEVELOPMENT 11 466 5.435e-11 9.367e-09
26 CARDIOVASCULAR SYSTEM DEVELOPMENT 13 788 5.346e-11 9.367e-09
27 CIRCULATORY SYSTEM DEVELOPMENT 13 788 5.346e-11 9.367e-09
28 LYMPHOCYTE ACTIVATION 10 342 6.047e-11 1.005e-08
29 B CELL DIFFERENTIATION 7 89 6.551e-11 1.051e-08
30 REGULATION OF CELL DEVELOPMENT 13 836 1.113e-10 1.726e-08
31 ORGAN MORPHOGENESIS 13 841 1.198e-10 1.798e-08
32 POSITIVE REGULATION OF CELL COMMUNICATION 16 1532 1.295e-10 1.883e-08
33 TISSUE MORPHOGENESIS 11 533 2.271e-10 3.203e-08
34 TUBE DEVELOPMENT 11 552 3.292e-10 4.505e-08
35 POSITIVE REGULATION OF RESPONSE TO STIMULUS 17 1929 3.582e-10 4.762e-08
36 LEUKOCYTE ACTIVATION 10 414 3.9e-10 5.041e-08
37 PATTERN SPECIFICATION PROCESS 10 418 4.282e-10 5.385e-08
38 NEUROGENESIS 15 1402 4.642e-10 5.684e-08
39 SOMITOGENESIS 6 62 4.799e-10 5.725e-08
40 NEURON FATE COMMITMENT 6 67 7.748e-10 9.013e-08
41 HEART MORPHOGENESIS 8 212 8.935e-10 1.014e-07
42 B CELL ACTIVATION 7 132 1.071e-09 1.186e-07
43 NEGATIVE REGULATION OF DEVELOPMENTAL PROCESS 12 801 1.098e-09 1.188e-07
44 CARDIAC CHAMBER DEVELOPMENT 7 144 1.971e-09 2.038e-07
45 SOMITE DEVELOPMENT 6 78 1.971e-09 2.038e-07
46 MATURE B CELL DIFFERENTIATION INVOLVED IN IMMUNE RESPONSE 4 13 3.343e-09 3.381e-07
47 SEGMENTATION 6 89 4.406e-09 4.362e-07
48 ENDOTHELIUM DEVELOPMENT 6 90 4.716e-09 4.572e-07
49 EMBRYONIC MORPHOGENESIS 10 539 4.958e-09 4.708e-07
50 REGULATION OF NEURON DIFFERENTIATION 10 554 6.444e-09 5.879e-07
51 EPITHELIAL CELL FATE COMMITMENT 4 15 6.368e-09 5.879e-07
52 NEGATIVE REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 11 740 7.111e-09 6.363e-07
53 CELL ACTIVATION 10 568 8.175e-09 7.177e-07
54 REGULATION OF BINDING 8 283 8.661e-09 7.463e-07
55 MATURE B CELL DIFFERENTIATION 4 17 1.108e-08 9.373e-07
56 CARDIAC CHAMBER MORPHOGENESIS 6 104 1.132e-08 9.408e-07
57 NEGATIVE REGULATION OF NEURON DIFFERENTIATION 7 191 1.406e-08 1.143e-06
58 ARTERY MORPHOGENESIS 5 51 1.425e-08 1.143e-06
59 ANTERIOR POSTERIOR PATTERN SPECIFICATION 7 194 1.565e-08 1.229e-06
60 NEGATIVE REGULATION OF CELL DIFFERENTIATION 10 609 1.585e-08 1.229e-06
61 REGIONALIZATION 8 311 1.806e-08 1.378e-06
62 POSITIVE REGULATION OF CELL DIFFERENTIATION 11 823 2.133e-08 1.601e-06
63 TUBE MORPHOGENESIS 8 323 2.423e-08 1.79e-06
64 SKIN DEVELOPMENT 7 211 2.793e-08 2.031e-06
65 POSITIVE REGULATION OF BINDING 6 127 3.763e-08 2.694e-06
66 SENSORY ORGAN DEVELOPMENT 9 493 3.887e-08 2.741e-06
67 NEURON DIFFERENTIATION 11 874 3.953e-08 2.745e-06
68 EPITHELIAL CELL DIFFERENTIATION 9 495 4.025e-08 2.754e-06
69 POSITIVE REGULATION OF MULTICELLULAR ORGANISMAL PROCESS 13 1395 5.502e-08 3.71e-06
70 POSITIVE REGULATION OF DEVELOPMENTAL PROCESS 12 1142 5.813e-08 3.864e-06
71 EPIDERMAL CELL DIFFERENTIATION 6 142 7.328e-08 4.803e-06
72 SKIN EPIDERMIS DEVELOPMENT 5 71 7.727e-08 4.993e-06
73 ENDOTHELIAL CELL DIFFERENTIATION 5 72 8.294e-08 5.287e-06
74 AUDITORY RECEPTOR CELL DIFFERENTIATION 4 28 9.419e-08 5.923e-06
75 EPIDERMIS DEVELOPMENT 7 253 9.682e-08 6.007e-06
76 ARTERY DEVELOPMENT 5 75 1.02e-07 6.244e-06
77 EMBRYO DEVELOPMENT ENDING IN BIRTH OR EGG HATCHING 9 554 1.053e-07 6.363e-06
78 REGULATION OF MUSCLE CELL DIFFERENTIATION 6 152 1.098e-07 6.553e-06
79 NEGATIVE REGULATION OF NERVOUS SYSTEM DEVELOPMENT 7 262 1.228e-07 7.235e-06
80 REGULATION OF CELL PROLIFERATION 13 1496 1.253e-07 7.285e-06
81 REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER IN RESPONSE TO HYPOXIA 4 32 1.647e-07 9.462e-06
82 MUSCLE TISSUE DEVELOPMENT 7 275 1.707e-07 9.687e-06
83 CARDIAC SEPTUM DEVELOPMENT 5 85 1.917e-07 1.05e-05
84 REGULATION OF STRIATED MUSCLE CELL DIFFERENTIATION 5 85 1.917e-07 1.05e-05
85 REGULATION OF ANATOMICAL STRUCTURE MORPHOGENESIS 11 1021 1.917e-07 1.05e-05
86 MUSCLE STRUCTURE DEVELOPMENT 8 432 2.266e-07 1.226e-05
87 HAIR CELL DIFFERENTIATION 4 35 2.391e-07 1.264e-05
88 B CELL ACTIVATION INVOLVED IN IMMUNE RESPONSE 4 35 2.391e-07 1.264e-05
89 POSITIVE REGULATION OF NERVOUS SYSTEM DEVELOPMENT 8 437 2.473e-07 1.293e-05
90 ANGIOGENESIS 7 293 2.623e-07 1.356e-05
91 MYOBLAST DIFFERENTIATION 4 37 3.009e-07 1.538e-05
92 NEGATIVE REGULATION OF CELL DEVELOPMENT 7 303 3.291e-07 1.664e-05
93 CARDIOCYTE DIFFERENTIATION 5 96 3.53e-07 1.766e-05
94 RESPONSE TO OXYGEN LEVELS 7 311 3.923e-07 1.921e-05
95 LYMPHOCYTE ACTIVATION INVOLVED IN IMMUNE RESPONSE 5 98 3.914e-07 1.921e-05
96 VASCULATURE DEVELOPMENT 8 469 4.23e-07 2.05e-05
97 IMMUNE SYSTEM PROCESS 14 1984 4.434e-07 2.108e-05
98 POSITIVE REGULATION OF CELL DEVELOPMENT 8 472 4.439e-07 2.108e-05
99 EAR DEVELOPMENT 6 195 4.781e-07 2.247e-05
100 MORPHOGENESIS OF AN EPITHELIAL SHEET 4 43 5.586e-07 2.548e-05
101 CELL FATE DETERMINATION 4 43 5.586e-07 2.548e-05
102 VENTRICULAR TRABECULA MYOCARDIUM MORPHOGENESIS 3 11 5.517e-07 2.548e-05
103 CELL DEVELOPMENT 12 1426 6.497e-07 2.935e-05
104 REGULATION OF TIMING OF CELL DIFFERENTIATION 3 12 7.348e-07 3.226e-05
105 COLUMNAR CUBOIDAL EPITHELIAL CELL DIFFERENTIATION 5 111 7.283e-07 3.226e-05
106 REGULATION OF DEVELOPMENT HETEROCHRONIC 3 12 7.348e-07 3.226e-05
107 CARDIAC SEPTUM MORPHOGENESIS 4 49 9.528e-07 4.143e-05
108 FOREBRAIN DEVELOPMENT 7 357 9.899e-07 4.265e-05
109 BLOOD VESSEL MORPHOGENESIS 7 364 1.127e-06 4.767e-05
110 MECHANORECEPTOR DIFFERENTIATION 4 51 1.121e-06 4.767e-05
111 NEGATIVE REGULATION OF MULTICELLULAR ORGANISMAL PROCESS 10 983 1.355e-06 5.68e-05
112 N TERMINAL PROTEIN AMINO ACID ACETYLATION 3 15 1.515e-06 6.294e-05
113 MAINTENANCE OF CELL NUMBER 5 132 1.718e-06 7.074e-05
114 MORPHOGENESIS OF AN ENDOTHELIUM 3 16 1.863e-06 7.602e-05
115 CELL ACTIVATION INVOLVED IN IMMUNE RESPONSE 5 139 2.216e-06 8.967e-05
116 EMBRYONIC DIGIT MORPHOGENESIS 4 61 2.317e-06 9.135e-05
117 CARDIAC MUSCLE TISSUE DEVELOPMENT 5 140 2.296e-06 9.135e-05
118 REGULATION OF VIRAL TRANSCRIPTION 4 61 2.317e-06 9.135e-05
119 CARDIAC VENTRICLE MORPHOGENESIS 4 62 2.474e-06 9.672e-05
120 NEUROEPITHELIAL CELL DIFFERENTIATION 4 63 2.639e-06 0.0001023
121 REGULATION OF PROTEIN ACETYLATION 4 64 2.811e-06 0.0001081
122 NEURONAL STEM CELL POPULATION MAINTENANCE 3 19 3.213e-06 0.0001225
123 REGULATION OF DNA TEMPLATED TRANSCRIPTION IN RESPONSE TO STRESS 4 67 3.381e-06 0.0001279
124 CELL FATE SPECIFICATION 4 71 4.267e-06 0.0001601
125 CENTRAL NERVOUS SYSTEM DEVELOPMENT 9 872 4.63e-06 0.0001723
126 MODULATION OF TRANSCRIPTION IN OTHER ORGANISM INVOLVED IN SYMBIOTIC INTERACTION 3 22 5.09e-06 0.0001836
127 MEMBRANE PROTEIN ECTODOMAIN PROTEOLYSIS 3 22 5.09e-06 0.0001836
128 SOMATIC STEM CELL DIVISION 3 22 5.09e-06 0.0001836
129 AORTA MORPHOGENESIS 3 22 5.09e-06 0.0001836
130 RHYTHMIC PROCESS 6 298 5.599e-06 0.0002004
131 APPENDAGE DEVELOPMENT 5 169 5.774e-06 0.0002035
132 LIMB DEVELOPMENT 5 169 5.774e-06 0.0002035
133 IMMUNE EFFECTOR PROCESS 7 486 7.598e-06 0.0002658
134 HAIR CYCLE 4 83 7.966e-06 0.0002746
135 MOLTING CYCLE 4 83 7.966e-06 0.0002746
136 NEGATIVE REGULATION OF GENE EXPRESSION 11 1493 8.089e-06 0.0002767
137 HEART TRABECULA MORPHOGENESIS 3 26 8.557e-06 0.0002885
138 N TERMINAL PROTEIN AMINO ACID MODIFICATION 3 26 8.557e-06 0.0002885
139 POSITIVE REGULATION OF CHROMATIN MODIFICATION 4 85 8.758e-06 0.0002932
140 HEAD DEVELOPMENT 8 709 9.17e-06 0.0003048
141 NEGATIVE REGULATION OF NITROGEN COMPOUND METABOLIC PROCESS 11 1517 9.422e-06 0.0003109
142 TISSUE REMODELING 4 87 9.607e-06 0.0003129
143 POSITIVE REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER INVOLVED IN CELLULAR RESPONSE TO CHEMICAL STIMULUS 3 27 9.617e-06 0.0003129
144 NEGATIVE REGULATION OF NOTCH SIGNALING PATHWAY 3 28 1.076e-05 0.0003453
145 REGULATION OF SPROUTING ANGIOGENESIS 3 28 1.076e-05 0.0003453
146 STEM CELL DIVISION 3 29 1.199e-05 0.0003821
147 COVALENT CHROMATIN MODIFICATION 6 345 1.29e-05 0.0004084
148 CARDIAC ATRIUM DEVELOPMENT 3 31 1.472e-05 0.0004627
149 ENDOCARDIAL CUSHION DEVELOPMENT 3 32 1.622e-05 0.0005032
150 BLOOD VESSEL REMODELING 3 32 1.622e-05 0.0005032
151 POSITIVE REGULATION OF TRANSMEMBRANE RECEPTOR PROTEIN SERINE THREONINE KINASE SIGNALING PATHWAY 4 100 1.669e-05 0.0005143
152 HEART VALVE DEVELOPMENT 3 34 1.953e-05 0.0005979
153 CARDIAC VENTRICLE DEVELOPMENT 4 106 2.101e-05 0.0006388
154 MEMBRANE PROTEIN PROTEOLYSIS 3 35 2.134e-05 0.0006447
155 POSITIVE REGULATION OF PROTEIN ACETYLATION 3 36 2.325e-05 0.0006981
156 POSITIVE REGULATION OF CELL PROLIFERATION 8 814 2.493e-05 0.0007435
157 REGULATION OF CELLULAR RESPONSE TO GROWTH FACTOR STIMULUS 5 229 2.511e-05 0.0007441
158 NEGATIVE REGULATION OF EPITHELIAL CELL DIFFERENTIATION 3 37 2.528e-05 0.0007445
159 REGULATION OF EMBRYONIC DEVELOPMENT 4 114 2.797e-05 0.0008186
160 NEPHRON DEVELOPMENT 4 115 2.895e-05 0.0008419
161 POSITIVE REGULATION OF VIRAL TRANSCRIPTION 3 39 2.967e-05 0.000847
162 TRABECULA MORPHOGENESIS 3 39 2.967e-05 0.000847
163 MUSCLE CELL DIFFERENTIATION 5 237 2.959e-05 0.000847
164 IMMUNE RESPONSE 9 1100 2.99e-05 0.0008484
165 POSITIVE REGULATION OF GROWTH 5 238 3.02e-05 0.0008515
166 SENSORY ORGAN MORPHOGENESIS 5 239 3.081e-05 0.0008636
167 AORTA DEVELOPMENT 3 41 3.454e-05 0.0009623
168 REGULATION OF EPITHELIAL CELL DIFFERENTIATION 4 122 3.65e-05 0.001011
169 T CELL DIFFERENTIATION 4 123 3.769e-05 0.001038
170 BETA CATENIN TCF COMPLEX ASSEMBLY 3 43 3.99e-05 0.001092
171 NEGATIVE REGULATION OF CELL DEATH 8 872 4.077e-05 0.001109
172 LEUKOCYTE CELL CELL ADHESION 5 255 4.197e-05 0.001135
173 POSITIVE REGULATION OF CELLULAR COMPONENT ORGANIZATION 9 1152 4.302e-05 0.001157
174 PROTEIN ACETYLATION 4 129 4.541e-05 0.001214
175 VENTRICULAR CARDIAC MUSCLE TISSUE DEVELOPMENT 3 45 4.578e-05 0.001217
176 NEGATIVE REGULATION OF CELL PROLIFERATION 7 643 4.609e-05 0.001219
177 REGULATION OF CELL DEATH 10 1472 4.783e-05 0.001257
178 HISTONE H3 ACETYLATION 3 46 4.892e-05 0.001279
179 INTERSPECIES INTERACTION BETWEEN ORGANISMS 7 662 5.543e-05 0.001433
180 SYMBIOSIS ENCOMPASSING MUTUALISM THROUGH PARASITISM 7 662 5.543e-05 0.001433
181 GLOMERULUS DEVELOPMENT 3 49 5.919e-05 0.001513
182 CARDIAC CELL DEVELOPMENT 3 49 5.919e-05 0.001513
183 MUSCLE ORGAN DEVELOPMENT 5 277 6.218e-05 0.001581
184 CELLULAR RESPONSE TO OXYGEN LEVELS 4 143 6.786e-05 0.001716
185 INTERACTION WITH SYMBIONT 3 52 7.078e-05 0.001771
186 POSITIVE REGULATION OF STRIATED MUSCLE CELL DIFFERENTIATION 3 52 7.078e-05 0.001771
187 NEURAL TUBE DEVELOPMENT 4 149 7.96e-05 0.00197
188 CARDIAC MUSCLE TISSUE MORPHOGENESIS 3 54 7.927e-05 0.00197
189 POSITIVE REGULATION OF CHROMOSOME ORGANIZATION 4 150 8.169e-05 0.002001
190 CHROMATIN REMODELING 4 150 8.169e-05 0.002001
191 NEGATIVE REGULATION OF MUSCLE CELL DIFFERENTIATION 3 55 8.376e-05 0.00203
192 REGULATION OF MYOTUBE DIFFERENTIATION 3 55 8.376e-05 0.00203
193 REGULATION OF CHROMATIN ORGANIZATION 4 152 8.6e-05 0.002073
194 POSITIVE REGULATION OF MUSCLE TISSUE DEVELOPMENT 3 56 8.841e-05 0.00211
195 OUTFLOW TRACT MORPHOGENESIS 3 56 8.841e-05 0.00211
196 POSITIVE REGULATION OF DEVELOPMENTAL GROWTH 4 156 9.51e-05 0.002246
197 POSITIVE REGULATION OF CELL PROJECTION ORGANIZATION 5 303 9.496e-05 0.002246
198 PROTEIN ACYLATION 4 159 0.0001024 0.002406
199 POSITIVE REGULATION OF CELL MORPHOGENESIS INVOLVED IN DIFFERENTIATION 4 162 0.00011 0.002573
200 CELL MORPHOGENESIS INVOLVED IN DIFFERENTIATION 6 513 0.000118 0.002745
201 EMBRYONIC HEART TUBE MORPHOGENESIS 3 62 0.0001199 0.002775
202 REGULATION OF PROTEIN BINDING 4 168 0.0001266 0.002836
203 LOOP OF HENLE DEVELOPMENT 2 11 0.0001268 0.002836
204 ENDOCARDIUM DEVELOPMENT 2 11 0.0001268 0.002836
205 NEGATIVE REGULATION OF SPROUTING ANGIOGENESIS 2 11 0.0001268 0.002836
206 POSITIVE REGULATION OF RECEPTOR BIOSYNTHETIC PROCESS 2 11 0.0001268 0.002836
207 EPITHELIAL TO MESENCHYMAL TRANSITION INVOLVED IN ENDOCARDIAL CUSHION FORMATION 2 11 0.0001268 0.002836
208 ENDOTHELIAL TUBE MORPHOGENESIS 2 11 0.0001268 0.002836
209 EYE DEVELOPMENT 5 326 0.0001338 0.00298
210 CELLULAR RESPONSE TO RETINOIC ACID 3 65 0.000138 0.003058
211 CARDIAC LEFT VENTRICLE MORPHOGENESIS 2 12 0.000152 0.003274
212 POSITIVE REGULATION BY HOST OF VIRAL TRANSCRIPTION 2 12 0.000152 0.003274
213 CARDIAC CONDUCTION SYSTEM DEVELOPMENT 2 12 0.000152 0.003274
214 AMYLOID PRECURSOR PROTEIN METABOLIC PROCESS 2 12 0.000152 0.003274
215 DISTAL TUBULE DEVELOPMENT 2 12 0.000152 0.003274
216 LATERAL VENTRICLE DEVELOPMENT 2 12 0.000152 0.003274
217 CHROMATIN MODIFICATION 6 539 0.0001545 0.003314
218 REGULATION OF CELL MORPHOGENESIS INVOLVED IN DIFFERENTIATION 5 337 0.0001563 0.003336
219 MUSCLE ORGAN MORPHOGENESIS 3 70 0.000172 0.003655
220 NEURONAL STEM CELL DIVISION 2 13 0.0001794 0.003694
221 EYELID DEVELOPMENT IN CAMERA TYPE EYE 2 13 0.0001794 0.003694
222 LEFT RIGHT AXIS SPECIFICATION 2 13 0.0001794 0.003694
223 CARDIOBLAST DIFFERENTIATION 2 13 0.0001794 0.003694
224 NEGATIVE REGULATION OF EPIDERMAL CELL DIFFERENTIATION 2 13 0.0001794 0.003694
225 NEUROBLAST DIVISION 2 13 0.0001794 0.003694
226 POSITIVE REGULATION OF GLUCONEOGENESIS 2 13 0.0001794 0.003694
227 EPITHELIAL CELL DEVELOPMENT 4 186 0.0001872 0.003821
228 REGULATION OF CELL PROJECTION ORGANIZATION 6 558 0.0001865 0.003821
229 POSITIVE REGULATION OF PROTEIN BINDING 3 73 0.0001949 0.003942
230 EMBRYONIC HEART TUBE DEVELOPMENT 3 73 0.0001949 0.003942
231 REGULATION OF CYTOKINE PRODUCTION 6 563 0.0001958 0.003944
232 BETA AMYLOID METABOLIC PROCESS 2 14 0.0002091 0.004195
233 ODONTOGENESIS OF DENTIN CONTAINING TOOTH 3 75 0.0002111 0.004216
234 POSITIVE REGULATION OF GENE EXPRESSION EPIGENETIC 3 78 0.0002371 0.004635
235 RESPONSE TO MURAMYL DIPEPTIDE 2 15 0.0002411 0.004635
236 ENDOCARDIAL CUSHION FORMATION 2 15 0.0002411 0.004635
237 RENAL TUBULE DEVELOPMENT 3 78 0.0002371 0.004635
238 ECTODERMAL PLACODE DEVELOPMENT 2 15 0.0002411 0.004635
239 REGULATION OF CELL PROLIFERATION INVOLVED IN HEART MORPHOGENESIS 2 15 0.0002411 0.004635
240 RESPIRATORY SYSTEM DEVELOPMENT 4 197 0.0002333 0.004635
241 ECTODERMAL PLACODE MORPHOGENESIS 2 15 0.0002411 0.004635
242 ECTODERMAL PLACODE FORMATION 2 15 0.0002411 0.004635
243 POSITIVE REGULATION OF MOLECULAR FUNCTION 10 1791 0.0002474 0.004736
244 POSITIVE REGULATION OF PROTEIN MODIFICATION PROCESS 8 1135 0.0002564 0.004889
245 REGULATION OF SYMBIOSIS ENCOMPASSING MUTUALISM THROUGH PARASITISM 4 205 0.0002715 0.005156
246 CARDIAC RIGHT VENTRICLE MORPHOGENESIS 2 16 0.0002753 0.005165
247 NEGATIVE REGULATION OF EPIDERMIS DEVELOPMENT 2 16 0.0002753 0.005165
248 APOPTOTIC PROCESS INVOLVED IN MORPHOGENESIS 2 16 0.0002753 0.005165
249 REGULATION OF TRANSMEMBRANE RECEPTOR PROTEIN SERINE THREONINE KINASE SIGNALING PATHWAY 4 207 0.0002817 0.005264
250 REGULATION OF ERBB SIGNALING PATHWAY 3 83 0.0002849 0.005302
251 POSITIVE REGULATION OF MUSCLE CELL DIFFERENTIATION 3 84 0.0002951 0.00547
252 CELL CELL ADHESION 6 608 0.0002964 0.005472
253 REGULATION OF CHROMATIN BINDING 2 17 0.0003117 0.005709
254 MEMBRANE PROTEIN INTRACELLULAR DOMAIN PROTEOLYSIS 2 17 0.0003117 0.005709
255 GLAND DEVELOPMENT 5 395 0.000326 0.005949
256 NEGATIVE REGULATION OF MYOTUBE DIFFERENTIATION 2 18 0.0003503 0.006342
257 PERICARDIUM DEVELOPMENT 2 18 0.0003503 0.006342
258 NEGATIVE REGULATION OF CELL COMMUNICATION 8 1192 0.0003576 0.00645
259 EMBRYONIC ORGAN DEVELOPMENT 5 406 0.0003698 0.006644
260 REGULATION OF NEURON PROJECTION DEVELOPMENT 5 408 0.0003782 0.006769
261 KIDNEY VASCULATURE DEVELOPMENT 2 19 0.0003911 0.006867
262 REGULATION OF CELL MIGRATION INVOLVED IN SPROUTING ANGIOGENESIS 2 19 0.0003911 0.006867
263 POSITIVE REGULATION OF CARDIAC MUSCLE CELL PROLIFERATION 2 19 0.0003911 0.006867
264 RENAL SYSTEM VASCULATURE DEVELOPMENT 2 19 0.0003911 0.006867
265 POSITIVE REGULATION OF VIRAL PROCESS 3 92 0.0003857 0.006867
266 NEPHRON EPITHELIUM DEVELOPMENT 3 93 0.0003981 0.006938
267 REGULATION OF DNA BINDING 3 93 0.0003981 0.006938
268 TELENCEPHALON DEVELOPMENT 4 228 0.0004064 0.007057
269 REGULATION OF GENE EXPRESSION EPIGENETIC 4 229 0.0004132 0.007148
270 TONGUE DEVELOPMENT 2 20 0.0004342 0.007427
271 MYELOID DENDRITIC CELL DIFFERENTIATION 2 20 0.0004342 0.007427
272 POSITIVE REGULATION OF NEURON PROJECTION DEVELOPMENT 4 232 0.000434 0.007427
273 MEMORY 3 98 0.0004642 0.007883
274 REGULATION OF CANONICAL WNT SIGNALING PATHWAY 4 236 0.000463 0.007883
275 CHROMATIN ORGANIZATION 6 663 0.0004704 0.007959
276 LEFT RIGHT PATTERN FORMATION 2 21 0.0004794 0.008024
277 REGULATION OF RECEPTOR BIOSYNTHETIC PROCESS 2 21 0.0004794 0.008024
278 APOPTOTIC PROCESS INVOLVED IN DEVELOPMENT 2 21 0.0004794 0.008024
279 MODIFICATION OF MORPHOLOGY OR PHYSIOLOGY OF OTHER ORGANISM 3 100 0.0004925 0.008213
280 KERATINOCYTE DIFFERENTIATION 3 101 0.000507 0.008395
281 CELL PROLIFERATION 6 672 0.0005052 0.008395
282 REGULATION OF ORGAN MORPHOGENESIS 4 242 0.0005089 0.008397
283 ENDOCARDIAL CUSHION MORPHOGENESIS 2 22 0.0005268 0.008601
284 REGULATION OF ANDROGEN RECEPTOR SIGNALING PATHWAY 2 22 0.0005268 0.008601
285 HISTONE H3 DEACETYLATION 2 22 0.0005268 0.008601
286 REGULATION OF MUSCLE TISSUE DEVELOPMENT 3 103 0.0005369 0.008705
287 REGULATION OF MUSCLE ORGAN DEVELOPMENT 3 103 0.0005369 0.008705
288 ODONTOGENESIS 3 105 0.0005679 0.009176
289 REGULATION OF EPIDERMAL GROWTH FACTOR ACTIVATED RECEPTOR ACTIVITY 2 23 0.0005764 0.009185
290 POSITIVE REGULATION OF MULTICELLULAR ORGANISMAL METABOLIC PROCESS 2 23 0.0005764 0.009185
291 POSITIVE REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER IN RESPONSE TO STRESS 2 23 0.0005764 0.009185
292 POSITIVE REGULATION OF COLLAGEN METABOLIC PROCESS 2 23 0.0005764 0.009185
293 SPINAL CORD DEVELOPMENT 3 106 0.0005839 0.009272
294 RESPONSE TO RETINOIC ACID 3 107 0.0006001 0.009497
295 NEGATIVE REGULATION OF BLOOD VESSEL ENDOTHELIAL CELL MIGRATION 2 24 0.0006282 0.009744
296 POSITIVE REGULATION OF CELLULAR RESPONSE TO TRANSFORMING GROWTH FACTOR BETA STIMULUS 2 24 0.0006282 0.009744
297 POSITIVE REGULATION OF TRANSFORMING GROWTH FACTOR BETA RECEPTOR SIGNALING PATHWAY 2 24 0.0006282 0.009744
298 NEGATIVE REGULATION OF MYOBLAST DIFFERENTIATION 2 24 0.0006282 0.009744
299 EPITHELIAL CELL DIFFERENTIATION INVOLVED IN KIDNEY DEVELOPMENT 2 24 0.0006282 0.009744
300 CARDIAC EPITHELIAL TO MESENCHYMAL TRANSITION 2 24 0.0006282 0.009744
301 SINGLE ORGANISM CELL ADHESION 5 459 0.0006465 0.009994
NumGOOverlapSizeP ValueAdj. P Value
1 NOTCH BINDING 8 18 5.389e-19 5.006e-16
2 TRANSCRIPTION FACTOR ACTIVITY PROTEIN BINDING 12 588 3.162e-11 1.469e-08
3 TRANSCRIPTION COACTIVATOR ACTIVITY 9 296 4.573e-10 1.416e-07
4 TRANSCRIPTION FACTOR BINDING 10 524 3.784e-09 8.789e-07
5 CHROMATIN BINDING 9 435 1.323e-08 2.458e-06
6 RNA POLYMERASE II TRANSCRIPTION FACTOR BINDING 5 104 5.265e-07 8.153e-05
7 RECEPTOR BINDING 12 1476 9.393e-07 0.0001247
8 CORE PROMOTER BINDING 5 152 3.439e-06 0.0003549
9 PEPTIDE N ACETYLTRANSFERASE ACTIVITY 4 67 3.381e-06 0.0003549
10 BETA CATENIN BINDING 4 84 8.355e-06 0.0006381
11 CALCIUM ION BINDING 8 697 8.095e-06 0.0006381
12 RNA POLYMERASE II REPRESSING TRANSCRIPTION FACTOR BINDING 3 27 9.617e-06 0.0006381
13 CHROMATIN DNA BINDING 4 80 6.878e-06 0.0006381
14 N ACETYLTRANSFERASE ACTIVITY 4 87 9.607e-06 0.0006381
15 NF KAPPAB BINDING 3 30 1.331e-05 0.0008241
16 ACETYLTRANSFERASE ACTIVITY 4 103 1.876e-05 0.001065
17 N ACYLTRANSFERASE ACTIVITY 4 104 1.949e-05 0.001065
18 MACROMOLECULAR COMPLEX BINDING 10 1399 3.091e-05 0.001566
19 STRUCTURE SPECIFIC DNA BINDING 4 118 3.203e-05 0.001566
20 TRANSCRIPTION FACTOR ACTIVITY RNA POLYMERASE II TRANSCRIPTION FACTOR BINDING 4 133 5.116e-05 0.002376
21 ACTIVATING TRANSCRIPTION FACTOR BINDING 3 57 9.322e-05 0.003936
22 REPRESSING TRANSCRIPTION FACTOR BINDING 3 57 9.322e-05 0.003936
23 HISTONE DEACETYLASE ACTIVITY H3 K14 SPECIFIC 2 12 0.000152 0.006139
24 SMAD BINDING 3 72 0.000187 0.007145
25 ENZYME BINDING 10 1737 0.0001923 0.007145
26 REGULATORY REGION NUCLEIC ACID BINDING 7 818 0.0002075 0.007415
27 PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR BINDING 2 15 0.0002411 0.008102
28 CORE PROMOTER PROXIMAL REGION DNA BINDING 5 371 0.0002442 0.008102
29 TRANSFERASE ACTIVITY TRANSFERRING ACYL GROUPS OTHER THAN AMINO ACYL GROUPS 4 211 0.000303 0.009478
30 TRANSCRIPTIONAL REPRESSOR ACTIVITY RNA POLYMERASE II TRANSCRIPTION FACTOR BINDING 3 86 0.0003163 0.009478
31 NAD DEPENDENT PROTEIN DEACETYLASE ACTIVITY 2 17 0.0003117 0.009478
NumGOOverlapSizeP ValueAdj. P Value
1 CHROMOSOME 10 880 4.933e-07 0.000144
2 CHROMATIN 8 441 2.651e-07 0.000144
3 NUCLEOPLASM PART 9 708 8.31e-07 0.0001618
4 NUCLEAR CHROMATIN 6 291 4.885e-06 0.0007133
5 GOLGI MEMBRANE 8 703 8.618e-06 0.001007
6 APICAL PART OF CELL 6 361 1.668e-05 0.001392
7 ACETYLTRANSFERASE COMPLEX 4 100 1.669e-05 0.001392
8 GOLGI APPARATUS PART 8 893 4.828e-05 0.003524
9 TRANSCRIPTION FACTOR COMPLEX 5 298 8.781e-05 0.005128
10 APICAL PLASMA MEMBRANE 5 292 7.978e-05 0.005128
11 NUCLEAR CHROMOSOME 6 523 0.0001311 0.006961
12 SIN3 COMPLEX 2 13 0.0001794 0.008733
13 TRANSCRIPTIONAL REPRESSOR COMPLEX 3 74 0.0002029 0.009114
14 ADA2 GCN5 ADA3 TRANSCRIPTION ACTIVATOR COMPLEX 2 15 0.0002411 0.009564
15 GOLGI APPARATUS 9 1445 0.0002456 0.009564

Over-represented Pathway

NumPathwayPathviewOverlapSizeP ValueAdj. P Value
1 hsa04330_Notch_signaling_pathway 31 47 5.891e-88 1.06e-85
2 hsa04320_Dorso.ventral_axis_formation 4 25 5.838e-08 5.254e-06
3 hsa04310_Wnt_signaling_pathway 5 151 3.329e-06 0.0001997
4 hsa04110_Cell_cycle 4 128 4.405e-05 0.001982
5 hsa04916_Melanogenesis 3 101 0.000507 0.01825
6 hsa00514_Other_types_of_O.glycan_biosynthesis 2 46 0.002306 0.06919
7 hsa04720_Long.term_potentiation 2 70 0.005259 0.1284
8 hsa04520_Adherens_junction 2 73 0.005706 0.1284
9 hsa04350_TGF.beta_signaling_pathway 2 85 0.007662 0.1532
10 hsa04722_Neurotrophin_signaling_pathway 2 127 0.0165 0.2969
11 hsa04630_Jak.STAT_signaling_pathway 2 155 0.02396 0.392

lncRNA-mediated sponge

(Download full result)

Num lncRNA miRNAs           miRNAs count     Gene Sponge regulatory network lncRNA log2FC lncRNA pvalue Gene log2FC Gene pvalue lncRNA-gene Pearson correlation
1

AGAP11

 hsa-miR-106b-5p;hsa-miR-17-5p;hsa-miR-181a-5p;hsa-miR-181b-5p;hsa-miR-19a-3p;hsa-miR-19b-3p;hsa-miR-20a-3p;hsa-miR-20a-5p;hsa-miR-25-3p;hsa-miR-590-5p;hsa-miR-93-5p 11 KAT2B Sponge network -1.728 0.00016 -1.911 0 0.441
2

AGAP11

 hsa-miR-103a-3p;hsa-miR-107;hsa-miR-130b-5p;hsa-miR-15a-5p;hsa-miR-15b-5p;hsa-miR-16-1-3p;hsa-miR-16-5p;hsa-miR-17-5p;hsa-miR-18a-3p;hsa-miR-200a-5p;hsa-miR-200b-5p;hsa-miR-25-3p;hsa-miR-423-5p;hsa-miR-424-5p;hsa-miR-590-5p 15 NOTCH2 Sponge network -1.728 0.00016 -0.258 0.28775 0.35
3

PCA3

 hsa-miR-106b-5p;hsa-miR-17-5p;hsa-miR-181a-5p;hsa-miR-181b-5p;hsa-miR-19a-3p;hsa-miR-19b-3p;hsa-miR-20a-3p;hsa-miR-20a-5p;hsa-miR-25-3p;hsa-miR-590-3p;hsa-miR-590-5p;hsa-miR-93-5p 12 KAT2B Sponge network -2.778 8.0E-5 -1.911 0 0.339

Quest ID: a9e2b9750235aa3f69b6a27848994b4e